wound ppt final
TRANSCRIPT
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Dr Tejus MNModerator: Dr Ramesh TS
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Skin Largest organ of the bodyPrimary function is protectiveComposed of several layers
Outer EpidermisDermis, containing the capillary network
Subcutaneous layer (hypodermis, adipose layer)
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To be regenerated
Cell egeneration
ECM regeneration
vascular Regeneration
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Wound A wound can be defined as “A cut or break in the continuity of any tissue, caused by injury or
operation”
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Wounds can be classified according to their nature:• Abrasion• Incision• Laceration• Open• Penetrating• Puncture• Septic etc……
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Types of healingHealing by primary intention
Healing by secondary Intention
Delayed primary healing
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Healing by primary intention
• Two opposed surfaces of a clean, incised wound are held together.
• No significant degree of tissue loss
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Healing by secondary intention
If there is significant tissue loss, healing
will begin by the production of granulation tissue
Granulation results in a broader scar Healing process can be slow due to
presence infection Daily dressing with debridment to
allow granulation tissue formation
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Delayed primary healing
If there is high infection risk – patient is given antibiotics and closure is delayed
for a few days e.g. bitesDelayed primary closure or secondary
sutureThe wound is initially cleaned, debrided
and observed The wound is purposely left open
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Phases of healingAll wounds heal following a specific
sequence of phases which may overlap
The phases are:
Inflammatory phaseProliferative phaseRemodelling or maturation phase
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Phases of healing
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Inflammatory phaseHEMOSTASIS In the inflammatory phase clotting
takes place in order to obtain hemostasis INFLAMMATION various factors are released to attract
cells that phagocytose debris, bacteria, and damaged tissue and release factors that initiate the proliferative phase of wound healing
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Inflammatory phaseDay 0 – 5The inflammatory phase is
characterised by heat, swelling, redness, pain and loss of function at the wound site
Early (haemostasis)Late (phagocytosis)This phase is short lived in the
absence of infection or contamination
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Proliferative phaseAngeogenesis Epithelialization Extracellular matrix
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Angiogenesis Collagen first detected at day 3 and
rapidly increases for approx. 3 weeks
Fibroplasia (fibroblast proliferation and synthesis) continues in parallel with re-vascularisation
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Angiogenesis Endothelial cells from the side of
vessels closest to the wound begin to migrate in response to angiogenic stimulus forming capillary buds
VEGF, TGF
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Granulation Day 3 – 14Granulation tissue consists of a
combination of cellular elements including:
Fibroblasts, inflammatory cells, new capillaries embedded in a loose extra-cellular collagen matrix
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Epithelialization The epidermis immediately adjacent
to the wound edge begins to thicken within 24hrs after injury
They migrate to the wound breaking collagen in healing wound
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Maturation Can last up to 2 yearsNew collagen forms, changing the shape
of the wound and increasing the tensile strength
Scar tissue, however is only ever approx. 50-80% as strong as the original tissue
During the remodelling process there is a gradual reduction in cellularity and vascularity of the tissue
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Contraction When there is unacceptable tissue
loss and an unsatisfactory cosmetic result
Wound contraction usually begins from day 5 and is complete at approx. day 12 - 15
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Factors affecting Immune statusBlood glucose levels (impaired white
cell function)Hydration (slows metabolism)Nutrition Oxygen and vascular supplyCorticosteroids (depress immune
function)
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Growth factors EGFPDGFFGFTGF-BInterlukinsInterferons
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WOUND ASSESSMENT
Size, depth & location
Wound bed:
• necrosis
• granulationSurrounding skin: colour, moisture,
Wound edge
Odour or exudate
Signs of infection
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Wound dressing Non-adherent wound contact
materials Films Hydrogels Hydrofibre dressings Hydrocolloids Foams Alginates Miscellaneous
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Film dressings
Semi-permeable primary or secondary dressings Clear polyurethane coated with adhesiveConformable, resistant to shear and tearDo not absorb exudateExamples: Tegaderm, Op-site
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Hydrocolloids
Pectin, gelatin, carboxymethylcellulose and
elastomers Environment for autolysis in sloughy
or necrotic wounds Occlusive --> hypoxic environment to encourage angiogenesis Waterproof e.g. Urgotul
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Foam dressings
Advanced polymer technologyHighly absorptiveSemi-permeableVarious types Adhesive and non-adhesive
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Hydrogels
Sheets or gelsStarch and polyacrylamide (94%
water)Low exudate, shallow woundsRe-hydrates necrotic tissueSecondary dressing neededMay cause skin maceration
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Alginates
Seaweed dressingsForm a gel over the woundModerate to high exudate woundsEasily removedCan cause painHelp to debride a wound