wp 6.4 genomics & colon cancer 9 th consortie meeing rome september 2006 pilot wp 6.4 genomics...
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WP 6.4 Genomics & colon cancer
9th Consortie Meeing Rome September 2006
Pilot WP 6.4
Genomics & colon cancer
WP 6.4 Genomics & colon cancer
9th Consortie Meeing Rome September 2006
4 genetic dept.
4 laboratories
50 surg.dept.
>20 gyn.dept.
HNPCC-registerToday:
Paper based
Future Aims:Interoperability
Communication
Further IT-support
Web-reporting of data
WP 6.4 Genomics & colon cancer
9th Consortie Meeing Rome September 2006
HNPCC-registerToday:
Paper based
Future Aims:Interoperability
Communication
Further IT-support
Web-reporting of data
WP 6.4 Genomics & colon cancer
9th Consortie Meeing Rome September 2006
Danish Health Data
Network
Web Server
Laboratory / Surgery Dep. / Genetic Dep.
Web Service Provider
Front endHNPCC
DB
HTML Web Service Not part of InfoBioMed
Web Page Client Web Service Client
Vali-dation
WP 6.4 Genomics & colon cancer
9th Consortie Meeing Rome September 2006
Invited departmentsGenetic
Department
Århus
Odense
Vejle
Hvidovre
SurgicalDepartment
Herning
Ålborg
Odense Hvidovre
ÅrhusLaboratory
Ålborg
Copenhagen
Hvidovre
Århus
100% functioning IP-addresses
WP 6.4 Genomics & colon cancer
9th Consortie Meeing Rome September 2006
WP 6.4 Genomics & colon cancer
9th Consortie Meeing Rome September 2006
WP 6.4 Genomics & colon cancer
9th Consortie Meeing Rome September 2006
Herning
Ålborg
Odense
GeneticDepartment
SurgicalDepartment
Laboratory
Ålborg
Copenhagen
Århus
VejleHvidovre
Odense
ÅrhusÅrhus
HvidovreHvidovre
WP 6.4 Genomics & colon cancer
9th Consortie Meeing Rome September 2006
WP 6.4 Genomics & colon cancer
9th Consortie Meeing Rome September 2006
WP 6.4 Genomics & colon cancer
9th Consortie Meeing Rome September 2006
Herning
Ålborg
Odense
GeneticDepartment
SurgicalDepartment
Laboratory
Ålborg
Copenhagen
Århus
VejleHvidovre
Odense
ÅrhusÅrhus
HvidovreHvidovre
II:1
Max Bergren
WP 6.4 Genomics & colon cancer
9th Consortie Meeing Rome September 2006
Herning
Ålborg
Odense
GeneticDepartment
SurgicalDepartment
Laboratory
Ålborg
Copenhagen
Århus
VejleHvidovre
Odense
ÅrhusÅrhus
HvidovreHvidovre
WP 6.4 Genomics & colon cancer
9th Consortie Meeing Rome September 2006
WP 6.4 Genomics & colon cancer
9th Consortie Meeing Rome September 2006
WP 6.4 Genomics & colon cancer
9th Consortie Meeing Rome September 2006
Herning
Ålborg
Odense
Laboratory
Ålborg
Copenhagen
Århus
VejleHvidovre
Odense
ÅrhusÅrhus
HvidovreHvidovre
MLH1, exon4,
c.350C>T, p.T117M
GeneticDepartment
SurgicalDepartment
WP 6.4 Genomics & colon cancer
9th Consortie Meeing Rome September 2006
HHUD – evaluation
WP 6.4 Genomics & colon cancer
9th Consortie Meeing Rome September 2006
International HL7 Interoperability Conference IHIC 2006
August 24-25, 2006, Cologne, Germany
WP 6.4 Genomics & colon cancer
9th Consortie Meeing Rome September 2006
WP 6.4 Genomics & colon cancer
9th Consortie Meeing Rome September 2006
FORTHFamily Information HL7v3 model
WP 6.4 Genomics & colon cancer
9th Consortie Meeing Rome September 2006
FORTHIndividual Information
HL7v3 model
WP 6.4 Genomics & colon cancer
9th Consortie Meeing Rome September 2006
Example: CDA for Surveillance messages
WP 6.4 Genomics & colon cancer
9th Consortie Meeing Rome September 2006
Summary
• HL7 interoperability can eliminate heterogeneity and speed-up reporting of laboratories, surgery, and genetic counseling departments to the Danish HNPCC registry.
• In the long run it can also facilitate cooperation among HNPCC registries in Europe.
• We have experimented with the HL7 v3 tools, Family History Model of the Clinical Genomics SIG and CDA release 2 to facilitate information exchange and promote interoperability.
WP 6.4 Genomics & colon cancer
9th Consortie Meeing Rome September 2006
Conclusions
HL7 v3 tools are useful but require a long time of work. Interoperability of the result is limited.
• Family History topic is the most promising solution in the long term.– collaboration with the Clinical Genomics SIG is
envisioned to share understanding and reach consensus.• CDA release 2 currently provides early feedback and max
flexibility among the solutions we investigated. • Implementation guides should be developed and shared with
the community for the CDA and the Family History model.– they are the key to interoperability!
2005 2006
WEB
XML/HL7
S t r u c t u r i n g E u r o p e a n B i o m e d i c a l I n f o r m a t i c s t o S u p p o r t I n d i v i d u a l i s e d H e a l t h c a r e
I S T - 5 0 7 5 8 5
w w w . i n f o b i o m e d . o r g
P r e - a n a l y s i s
C u r r e n t S t a t u s f o r E x c h a n g e o f D a t a o n H N P C C - f a m i l i e s
W P 6 . 4 – G e n o m i c s a n d c o l o n c a n c e r
I n t e r n a l d o c u m e n t v 0 . 2 F i n a l
S t r u c t u r i n g E u r o p e a n B i o m e d i c a l I n f o r m a t i c s t o S u p p o r t I n d i v i d u a l i s e d H e a l t h c a r e
I S T - 5 0 7 5 8 5
w w w . i n f o b i o m e d . o r g
P r e - a n a l y s i s
C u r r e n t S t a t u s f o r E x c h a n g e o f D a t a o n H N P C C - f a m i l i e s
W P 6 . 4 – G e n o m i c s a n d c o l o n c a n c e r
I n t e r n a l d o c u m e n t v 0 . 2 F i n a l
SNP2005Leicester
SNP2005Leicester
FORTH
UPM
Internet
Web Server
Laboratory / Surgery Dep. / Genetic Dep.
Web Service Provider
Front endHNPCC
DB
HTML / HTTP Web Service / HTTP Web Service / HTTP
Web Page Client Web Service Client
ImplementationImplementationFUNEN
HNPCC
2007
HHUD
EvaluationEvaluation
Custodix
Aveiro
ISCIII
WP 6.4 Genomics & colon cancer
9th Consortie Meeing Rome September 2006
Specific output WP 6.4
• Current status data exchange HNPCC
• 4 XML standards on clinical content
• Design of XML documents
• WEB service client
• Implementation & evaluation of WEB-client
• Ethical, legal and security issues
• Early HL7 and CDA experience
• Dissemination experience
WP 6.4 Genomics & colon cancer
9th Consortie Meeing Rome September 2006
Experience ??