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Thursday 26 | Friday 27 October 2017

ANNUAL Ri.MED SCIENTIFIC SYMPOSIUMXI

ANNUAL Ri.MED SCIENTIFIC SYMPOSIUMXI

Recent advances in basic and clinical vision research have made ophthalmology one of the most exciting fields of technological and therapeutic innovations. This 11 annual Ri.MED Symposium will bring together renowned academic and industry experts to discuss recent breakthroughs in vision restoration therapies. The symposium will provide an overview of the latest advances in gene therapy, neuroprotection, visual prostheses, and stem cell treatments for currently incurable eye diseases.Special emphasis will be given to novel pathophysiological mechanisms and therapeutic targets for age-related macular degeneration.We are hopeful that this symposium, which brings together some of the best and brightest minds in vision restoration, will catalyze new collaborations that advance integrative multidisciplinary research and expedite the evolution of laboratory discoveries into new diagnostic tools, medical devices, and therapies for patients.

The Institut de la Vision is one of the most important research centers in Europe on eye diseases. It brings together in a single building researchers, clinicians and industrial partners in order to discover, test and develop treatments and technological innovations for the benefit of visually impaired patients.

Ri.MED Foundation was founded by the Italian Government as an international public-private partnership, with the mission to develop and translate the progress of biomedical research into patient care and to have a socio-economic impact in southern Italy.Thanks to its strategic alliances with its founding partners and with ISMETT IRCCS, Ri.MED Foundation is focused on advancing drug discovery, regenerative medicine and tissue engineering programs towards preclinical development.

The University of Pittsburgh, one of the top 10 recipients of research support from the US National Institutes of Health (NIH), is a leader in cutting-edge biomedical research that betters the human condition and advances the fundamental understanding of medical science. Among the University’s premier specialized research centers are those within the Department of Ophthalmology and the Ophthalmology and Visual Sciences Research Center, which, along with the UPMC Eye Center, share the goal of understanding the visual system and improving quality of life through the preservation and restoration of vision.

FONDAZIONE Ri.MED

UNIVERSITY OF PITTSBURGH

INSTITUT DE LA VISION

Jointly organized by

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ECM provider

Regione SicilianaConsiglio Nazionale

delle RicerchePresidenza

del Consiglio dei Ministri

RI.MED FOUNDING PARTNERS

Alberto Auricchio, M.D.Principal Investigator, TIGEM; Molecular Therapy Program Coordinator, TIGEM; Head of Vector Core, TIGEM; Associate Professor of Medical Genetics, Department of Translational Medicine, University of Naples Federico II.

Fabio Benfenati, M.D.Director, Center for Synaptic Neuroscience and Technology, Italian Institute of Technology; Professor of Neurophysiology and Head, Laboratory of Molecular and Cellular Neurophysiology, University of Genova Medical School.

Chiara M. Eandi, M.D., Ph.DProfessor of Ophthalmology, Department of Surgical Sciences, Eye Clinic, University of Torino.

Olivier Goureau, Ph.DGroup Leader, Retinal development and repair: use of pluripotent stem cells, Institut de la Vision.

Bruno Gridelli, M.D.Vice President, Ri.MED Foundation;Executive Vice President, UPMC International; Director, UPMC Italy;Professor of Surgery, University of Pittsburgh.

Vishal Jhanji, M.D.Professor of Ophthalmology, University of Pittsburgh School of Medicine.

Arthur S. Levine, M.D.Senior Vice Chancellor for the Health Sciences, Petersen Dean of Medicine, and Professor of Medicine and Molecular Genetics, University of Pittsburgh.

Flavio Mantelli, M.D., Ph.DChief Medical Officer, Dompé Ophthalmology Division.

Valeria Marigo, Ph.DAssociate Professor of Molecular Biology, Department of Biomedical Sciences, University of Modena and Reggio Emilia.

Stephen Moss, Ph.DNorman Ashton Professor of Biomedical Research, Institute of Ophthalmology, University College London.

Alessandro Padova, Ph.DCEO, Ri.MED Foundation.

Michel Paques, M.D. Ph.DProfessor of Ophthalmology, Group Leader, Retinal Degeneration and Microvascular Remodeling, Institut de la Vision.

Graziella Pellegrini, Ph.DDirector, Cell Therapy Program, Center for Regenerative Medicine Stefano Ferrari; Professor of Cell Biology, University of Modena and Reggio Emilia.

Serge Picaud, Ph.DGroup Leader, Visual Information Processing, Institut de la Vision.

Camillo Ricordi, M.D.President, Ri.MED Foundation;Stacy Joy Goodman Professor of Surgery; Distinguished Professor of Medicine;Professor of Biomedical Engineering Microbiology and Immunology;Director, Diabetes Research Institute and Cell Transplant Center, University of Miami. Botond Roska, M.D., Ph.DSenior Group Leader, Friedrich Miescher Institute for Biomedical Research;Professor of Medicine, University of Basel.

Florian Sennlaub, M.D., Ph.DGroup Leader, Ocular Inflammation and Degeneration, Institut de la Vision.

Debasish Sinha, M.S., Ph.DSalvitti Professor of Ophthalmology, University of Pittsburgh School of Medicine.

Matthew A. Smith, Ph.DAssistant Professor of Ophthalmology, University of Pittsburgh School of Medicine.

José-Alain Sahel, M.D.Eye and Ear Foundation Professor and Chair of Ophthalmology, University of Pittsburgh; School of Medicine Director; UPMC Eye Center Director, Institut de La Vision.

Masayo Takahashi, M.D., Ph.DProject Leader, RIKEN Center for Developmental Biology, Kobe City Medical Center General Hospital.

Gian Marco Tosi, M.D., Ph.DOphthalmology Unit, Department of Medicine, Surgery and Neuroscience, University of Siena.

SPEAKERS

Florian Sennlaub, M.D., Ph.DThe Pathogenic Role of Chronic Inflammation in Age-Related Macular DegenerationMichel Paques, M.D., Ph.DCellular-Scale, Time Lapse In Vivo Imaging in the Human Eye

Chiara M. Eandi, M.D., Ph.DBiomarkers and New Treatments for AMD

LIGHT LUNCH

SESSION 3: AGE-RELATED MACULAR DEGENERATION

SESSION 5: CORNEA

Flavio Mantelli, M.D., Ph.DUnmet Needs in Corneal Disease: The Advent of Biotech Drugs

Vishal Jhanji, M.D.The Role of MDM2/p53 in Pterygium Pathogenesis

Final Discussion & Symposium Conclusion

Botond Roska, M.D., Ph.DTargeting Human Retinal Cell Types to Restore Vision

COFFEE BREAK

Friday, 27 OctoberSymposium Registration

SESSION 2: VISUAL INFORMATION PROCESSING AND VISUAL PROSTHESES

Serge Picaud, Ph.DVisual Restoration by Retinal Prostheses and Optogenetic Therapy:Preclinical Validation in Non-Human Primates

Fabio Benfenati, M.D.A Fully Organic Retinal Prosthesis Restores Vision in a Rat Modelof Degenerative BlindnessMatthew A. Smith, Ph.DA Brain-Computer Interface for Visual Attention

08:45 AM

09:15 AM

09:45 AM

10:15 AM

10:45 AM

11:00 AM

11:30 AM

12:00 PM

12:30 PM

SESSION 4: DEGENERATIVE EYE DISEASES

Debasish Sinha, M.S., Ph.DThe Crucial Impact of Lysosomes in Age-Related Macular Degeneration

Gian Marco Tosi, M.D., Ph.DAge-Related Macular Degeneration Biomarkers in the Aqueous Humor

Stephen Moss, Ph.DNovel Approaches to the Treatment of Retinal Vascular Disease

COFFEE BREAK

01:30 PM

02:00 PM

02:30 PM

03:00 PM

03:30 PM

04:00 PM

04:30 PM

ANNUAL Ri.MED SCIENTIFIC SYMPOSIUM

Thursday, 26 October

02:00 PM

01:30 PM

Welcome and IntroductionCamillo Ricordi, M.D.Bruno Gridelli, M.D. Alessandro Padova, Ph.DArthur S. Levine, M.D.

Symposium Registration

SESSION 1: REGENERATIVE THERAPIES FOR RESTORING VISION

03:00 PM José-Alain Sahel, M.D.From Cone Rescue to Optogenetics

Valeria Marigo, Ph.DNeuroprotective Approaches for Retinitis Pigmentosa

03:30 PM

Alberto Auricchio, M.D.Large Gene Delivery to the Retina with AAV Vectors

04:00 PM

COFFEE BREAK04:30 PM

Masayo Takahashi, M.D., Ph.DRetinal Cell Therapy Using iPS Cells

Olivier Goureau, Ph.D

Graziella Pellegrini, Ph.DFrom Discovery to Approval of Advanced Therapy MedicinalProduct-Containing Stem Cells in the EUFinal Discussion

05:00 PM

06:00 PM

06:30 PM

XI

PROGRAM

08:15 AM

Application of Human Pluripotent Stem Cells for Modellingand Treating Retinal Diseases

05:30 PM