[xls] · web viewflagellar p-ring protein stig1 pf04885 stigma-specific protein, stig1 duf3295...

Sheet1

Total numbers of proteins

Apis mellifera Nasonia vitripennis16569 9,257.00 9254

PFAM domain hits and odds ratios

87 63 -0.26 45 0.0826 11 0.28 9 0.4811 11 -0.58 6 0.0297 115 -0.76 110 -0.7150 44 -0.46 47 -0.5212 19 -1.04 14 -0.743 1 0.52 0 100

50 42 -0.41 26 0.0786 112 -0.85 98 -0.7243 40 -0.51 34 -0.353 11 -1.88 12 -1.97

11 7 -0.13 9 -0.3819 23 -0.77 20 -0.633 2 -0.18 5 -1.098 12 -0.99 12 -0.991 0 100.00 0 100

23 27 -0.74 24 -0.6358 65 -0.70 61 -0.649 7 -0.33 7 -0.331 4 -1.97 2 -1.282 1 0.11 1 0.11

12 21 -1.14 19 -1.0488 90 -0.61 109 -0.810 6 -0.07 5 0.1178 94 -0.77 85 -0.671 1 -0.58 2 -1.28

20 16 -0.36 14 -0.2334 17 0.11 11 0.550 0 - 0 00 0 - 0 01 1 -0.58 1 -0.580 1 -100.00 1 -1001 2 -1.28 2 -1.283 3 -0.58 2 -0.18

17 11 -0.15 15 -0.4671 87 -0.79 72 -0.62 3 -0.99 3 -0.99

25 18 -0.25 13 0.071 0 100.00 0 100

58 55 -0.53 39 -0.193 2 -0.18 2 -0.18

23 12 0.07 25 -0.672 4 -1.28 2 -0.58

Solenopsis invicta OGS 2.2.2

Number of Solenopsis invicta

OGS 2.2.2 hits

Number of Apis

hitsodds ratio

(S invicta/ Apis)

Number of Nasonia

hits

odds ratio (S invicta/ Nasonia)

Sheet1

3 2 -0.18 2 -0.1889 86 -0.55 78 -0.45

158 126 -0.36 87 0.012 1 0.11 1 0.11

15 11 -0.27 17 -0.714 5 -0.81 4 -0.584 4 -0.58 4 -0.58

21 22 -0.63 15 -0.2525 23 -0.50 13 0.076 5 -0.40 5 -0.48 10 -0.81 12 -0.99

42 37 -0.46 30 -0.258 10 -0.81 12 -0.99

12 12 -0.58 22 -1.1926 18 -0.21 19 -0.273 7 -1.43 6 -1.281 2 -1.28 1 -0.58

17 20 -0.75 13 -0.311 1 -0.58 1 -0.582 2 -0.58 2 -0.58

135 49 0.43 88 -0.164 3 -0.29 5 -0.81

205 209 -0.61 200 -0.5731 32 -0.62 38 -0.7987 101 -0.74 94 -0.663 3 -0.58 0 1000 0 100.00 1 -100

19 3 1.26 19 -0.58107 114 -0.65 116 -0.6722 1 2.51 54 -1.4842 2 2.46 220 -2.268 6 -0.29 9 -0.76 3 0.11 5 -0.42 2 -0.58 1 0.115 5 -0.58 4 -0.36

69 71 -0.61 86 -0.8114 9 -0.14 9 -0.1425 29 -0.73 26 -0.623 4 -0.87 5 -1.091 2 -1.28 0 02 1 0.11 2 -0.58

73 62 -0.42 156 -1.3523 19 -0.39 17 -0.2814 17 -0.78 15 -0.656 4 -0.18 7 -0.74

10 8 -0.36 7 -0.237 8 -0.72 10 -0.944 7 -1.14 3 -0.29

262 145 0.01 124 0.1776 76 -0.59 66 -0.4456 14 0.81 69 -0.815 14 -0.51 13 -0.4441 31 -0.30 27 -0.170 1 -100.00 1 -100

21 20 -0.53 15 -0.2521 24 -0.72 17 -0.3780 62 -0.33 96 -0.77

Sheet1

31 17 0.02 17 0.0227 7 0.77 9 0.5243 7 1.23 12 0.712 8 -0.18 6 0.118 6 -0.29 10 -0.817 6 -0.43 9 -0.832 5 -1.50 1 0.110 1 -100.00 0 08 1 1.50 0 1002 1 0.11 0 1002 8 -1.97 5 -1.5

12 11 -0.50 10 -0.41 1 -0.58 1 -0.582 2 -0.58 1 0.112 0 100.00 1 0.11

18 15 -0.40 8 0.231 0 100.00 0 100

20 35 -1.14 89 -2.081 1 -0.58 0 100

10 8 -0.36 14 -0.920 0 - 0 0

58 41 -0.24 41 -0.240 0 100.00 0 1005 7 -0.92 5 -0.58

10 12 -0.77 10 -0.5819 17 -0.47 16 -0.4139 33 -0.42 40 -0.614 3 -0.29 6 -0.992 4 -1.28 7 -1.842 1 0.11 2 -0.580 2 -100.00 0 01 1 -0.58 0 1002 4 -1.28 5 -1.53 1 0.52 0 1005 4 -0.36 6 -0.778 1 1.50 0 1002 2 -0.58 1 0.110 1 -100.00 0 0

16 23 -0.95 25 -1.033 2 -0.18 6 -1.28

23 20 -0.44 18 -0.348 9 -0.70 8 -0.58

31 34 -0.68 32 -0.625 3 -0.07 3 -0.07

15 22 -0.97 28 -1.218 8 -0.58 8 -0.584 4 -0.58 4 -0.58

39 48 -0.79 49 -0.811 1 -0.58 0 100

15 14 -0.51 15 -0.582 0 100.00 0 1001 1 -0.58 2 -1.282 2 -0.58 2 -0.582 2 -0.58 2 -0.582 0 100.00 0 1002 5 -1.50 1 0.115 3 -0.07 2 0.33

Sheet1

45 41 -0.49 32 -0.2459 69 -0.74 54 -0.540 41 -0.61 30 -0.314 12 -0.43 12 -0.4311 13 -0.75 13 -0.752 2 -0.58 3 -0.998 10 -0.81 6 -0.29

25 21 -0.41 25 -0.584 4 -0.58 2 0.117 9 -0.83 6 -0.43

24 29 -0.77 26 -0.664 4 -0.58 5 -0.811 2 -1.28 3 -1.681 0 100.00 2 -1.286 8 -0.87 4 -0.181 0 100.00 2 -1.281 2 -1.28 1 -0.581 1 -0.58 2 -1.280 0 - 1 -1006 4 -0.18 11 -1.191 1 -0.58 1 -0.582 1 0.11 1 0.115 12 -1.46 3 -0.070 0 - 1 -100

11 11 -0.58 9 -0.380 0 - 1 -1003 10 -1.79 2 -0.184 3 -0.29 3 -0.291 5 -2.19 2 -1.283 6 -1.28 3 -0.58

22 12 0.02 21 -0.544 6 -0.99 5 -0.811 1 -0.58 1 -0.581 1 -0.58 1 -0.585 4 -0.36 5 -0.585 3 -0.07 3 -0.074 3 -0.29 3 -0.299 6 -0.18 8 -0.47

16 17 -0.64 9 -0.015 3 -0.07 3 -0.07

19 14 -0.28 15 -0.352 2 -0.58 3 -0.993 1 0.52 0 1002 1 0.11 2 -0.581 0 100.00 0 1004 3 -0.29 1 0.80 1 -100.00 0 1001 0 100.00 1 -0.581 3 -1.68 1 -0.58

36 24 -0.18 17 0.1722 27 -0.79 30 -0.8915 13 -0.44 13 -0.441 2 -1.28 0 1007 8 -0.72 6 -0.431 1 -0.58 1 -0.582 3 -0.99 5 -1.56 7 -0.74 7 -0.74

Sheet1

0 0 - 0 00 3 -100.00 1 -1000 2 -100.00 1 -1003 2 -0.18 3 -0.581 2 -1.28 3 -1.680 0 100.00 0 100

22 36 -1.08 31 -0.933 3 -0.58 5 -1.092 6 -1.68 5 -1.51 0 - 0 02 4 -1.28 2 -0.585 4 -0.36 2 0.33

11 10 -0.49 16 -0.968 10 -0.81 14 -1.14

20 23 -0.72 21 -0.6317 13 -0.31 16 -0.521 1 -0.58 0 1002 3 -0.99 3 -0.993 3 -0.58 4 -0.877 7 -0.58 5 -0.253 2 -0.18 2 -0.180 1 -100.00 0 03 3 -0.58 2 -0.18

13 11 -0.42 10 -0.321 2 -1.28 4 -1.971 0 100.00 0 1001 1 -0.58 5 -2.192 1 0.11 1 0.11

12 17 -0.93 18 -0.991 1 -0.58 1 -0.581 0 100.00 0 100

75 89 -0.76 96 -0.8474 73 -0.57 83 -0.70 0 - 0 01 0 100.00 0 1001 2 -1.28 1 -0.582 2 -0.58 2 -0.580 0 100.00 0 1006 1 1.21 4 -0.182 2 -0.58 2 -0.58

14 15 -0.65 13 -0.510 0 - 1 -1005 4 -0.36 2 0.330 0 - 1 -1006 4 -0.18 5 -0.46 4 -0.18 4 -0.184 5 -0.81 7 -1.141 2 -1.28 0 1004 3 -0.29 2 0.11

11 10 -0.49 7 -0.1311 14 -0.82 14 -0.826 6 -0.58 6 -0.580 0 - 0 02 2 -0.58 2 -0.582 1 0.11 3 -0.990 0 - 1 -100

11 11 -0.58 13 -0.75

Sheet1

8 8 -0.58 4 0.113 0 100.00 1 0.521 1 -0.58 2 -1.283 2 -0.18 3 -0.582 5 -1.50 5 -1.5

30 30 -0.58 28 -0.516 7 -0.74 3 0.111 0 100.00 1 -0.584 8 -1.28 4 -0.582 1 0.11 2 -0.582 4 -1.28 2 -0.583 2 -0.18 2 -0.183 1 0.52 1 0.522 3 -0.99 2 -0.583 2 -0.18 2 -0.18

11 10 -0.49 7 -0.131 0 100.00 2 -1.280 0 100.00 1 -1000 0 - 0 0

17 14 -0.39 11 -0.151 1 -0.58 0 100

29 34 -0.74 42 -0.962 2 -0.58 4 -1.28

17 16 -0.52 37 -1.362 1 0.11 2 -0.583 3 -0.58 1 0.520 0 - 1 -1002 2 -0.58 2 -0.583 4 -0.87 4 -0.87

23 27 -0.74 19 -0.390 0 - 1 -1003 3 -0.58 3 -0.583 4 -0.87 5 -1.097 10 -0.94 13 -1.21 0 100.00 0 1002 1 0.11 0 1001 1 -0.58 1 -0.581 2 -1.28 1 -0.583 3 -0.58 2 -0.183 1 0.52 2 -0.181 1 -0.58 0 100

36 11 0.60 5 1.392 2 -0.58 1 0.11

42 50 -0.76 60 -0.945 4 -0.36 3 -0.073 4 -0.87 2 -0.184 1 0.80 1 0.83 3 -0.58 6 -1.281 1 -0.58 0 03 3 -0.58 2 -0.180 0 - 0 00 0 - 2 -100

14 5 0.45 1 2.065 2 0.33 3 -0.070 1 -100.00 0 09 6 -0.18 6 -0.181 1 -0.58 1 -0.58

Sheet1

2 2 -0.58 2 -0.580 0 - 0 08 2 0.80 1 1.56 6 -0.58 6 -0.584 5 -0.81 10 -1.5

20 22 -0.68 13 -0.150 1 -100.00 0 04 8 -1.28 4 -0.583 2 -0.18 1 0.520 0 - 1 -1007 10 -0.94 9 -0.83

42 31 -0.28 55 -0.862 3 -0.99 1 0.110 1 -100.00 0 08 7 -0.45 8 -0.584 5 -0.81 2 0.111 0 100.00 1 -0.586 10 -1.09 46 -2.623 1 0.52 1 0.524 4 -0.58 3 -0.296 9 -0.99 5 -0.44 7 -1.14 4 -0.581 2 -1.28 2 -1.281 1 -0.58 0 1000 2 -100.00 0 01 1 -0.58 1 -0.587 5 -0.25 9 -0.830 0 - 2 -100

21 23 -0.67 21 -0.5815 15 -0.58 15 -0.58

189 173 -0.50 165 -0.453 1 0.52 1 0.523 5 -1.09 5 -1.094 4 -0.58 2 0.113 6 -1.28 4 -0.874 3 -0.29 4 -0.58

10 10 -0.58 7 -0.233 3 -0.58 3 -0.581 3 -1.68 1 -0.582 2 -0.58 2 -0.58

51 37 -0.26 33 -0.1511 13 -0.75 15 -0.8913 12 -0.50 8 -0.12 3 -0.99 2 -0.581 1 -0.58 2 -1.282 2 -0.58 2 -0.580 0 - 0 03 5 -1.09 2 -0.180 0 - 0 00 2 -100.00 0 00 0 - 0 00 0 100.00 1 -100

12 8 -0.18 12 -0.581 0 100.00 0 1003 3 -0.58 6 -1.28

31 21 -0.19 19 -0.096 7 -0.74 4 -0.18

Sheet1

13 16 -0.79 14 -0.6629 31 -0.65 16 0.011 2 -1.28 1 -0.58

41 49 -0.76 49 -0.761 1 -0.58 1 -0.58

20 17 -0.42 18 -0.480 0 - 0 0

11 8 -0.26 9 -0.3829 26 -0.47 21 -0.261 0 100.00 1 -0.581 1 -0.58 4 -1.972 1 0.11 2 -0.58

22 25 -0.71 24 -0.671 0 100.00 0 1002 3 -0.99 8 -1.971 0 - 2 -1.283 2 -0.18 1 0.521 2 -1.28 1 -0.58

10 11 -0.68 12 -0.772 2 -0.58 1 0.111 3 -1.68 3 -1.680 0 - 1 -1006 4 -0.18 4 -0.188 10 -0.81 4 0.110 0 - 1 -100

16 13 -0.37 14 -0.451 1 -0.58 0 1002 2 -0.58 1 0.114 3 -0.29 3 -0.29

10 6 -0.07 11 -0.680 0 - 1 -1000 0 - 1 -1000 1 -100.00 0 03 4 -0.87 4 -0.873 1 0.52 0 100

12 12 -0.58 13 -0.661 1 -0.58 1 -0.583 2 -0.18 2 -0.184 6 -0.99 7 -1.141 1 -0.58 1 -0.580 2 -100.00 1 -100

12 10 -0.40 9 -0.32 5 -1.50 1 0.113 5 -1.09 2 -0.181 1 -0.58 1 -0.58

11 14 -0.82 6 0.022 2 -0.58 1 0.11

18 9 0.11 23 -0.836 5 -0.40 3 0.110 1 -100.00 0 1001 2 -1.28 2 -1.282 3 -0.99 0 100

14 13 -0.51 12 -0.431 1 -0.58 1 -0.581 1 -0.58 0 100

25 16 -0.14 14 016 15 -0.52 13 -0.38

Sheet1

1 1 -0.58 0 01 0 100.00 0 100

28 19 -0.19 23 -0.3922 29 -0.86 23 -0.6326 23 -0.46 26 -0.580 0 - 0 00 1 -100.00 0 00 0 - 0 00 3 -100.00 2 -1005 2 0.33 0 1000 1 -100.00 0 02 0 100.00 3 -0.99

39 34 -0.45 42 -0.6699 96 -0.56 91 -0.51 0 100.00 1 -0.584 4 -0.58 5 -0.810 2 -100.00 0 1001 1 -0.58 1 -0.58

57 47 -0.39 36 -0.123 1 0.52 2 -0.181 0 100.00 0 1000 0 - 1 -1000 1 -100.00 0 01 6 -2.37 2 -1.281 0 100.00 0 1005 0 100.00 1 1.031 0 100.00 2 -1.286 3 0.11 7 -0.744 3 -0.29 4 -0.58

14 8 -0.02 7 0.1113 11 -0.42 13 -0.586 6 -0.58 7 -0.74

13 14 -0.66 12 -0.532 25 -0.34 20 -0.111 0 100.00 0 1009 3 0.52 15 -1.091 0 100.00 0 1000 0 - 0 03 2 -0.18 2 -0.181 0 100.00 0 1000 0 - 0 00 0 - 1 -1002 0 100.00 1 0.113 7 -1.43 4 -0.87

26 6 0.89 5 1.072 2 -0.58 3 -0.990 1 -100.00 0 03 4 -0.87 5 -1.090 0 - 0 01 1 -0.58 0 100

10 7 -0.23 8 -0.365 6 -0.76 4 -0.36

118 96 -0.38 84 -0.2456 35 -0.11 60 -0.654 2 0.11 3 -0.291 2 -1.28 0 1003 3 -0.58 2 -0.18

Sheet1

1 1 -0.58 1 -0.5821 20 -0.53 21 -0.5822 7 0.56 9 0.315 7 -0.92 8 -1.05

11 11 -0.58 15 -0.893 3 -0.58 4 -0.87

10 8 -0.36 6 -0.072 2 -0.58 2 -0.583 2 -0.18 1 0.522 4 -1.28 1 0.118 7 -0.45 8 -0.583 2 -0.18 5 -1.09

17 18 -0.64 20 -0.755 6 -0.76 5 -0.586 5 -0.40 4 -0.187 8 -0.72 7 -0.581 1 -0.58 3 -1.68

25 27 -0.66 25 -0.581 1 -0.58 2 -1.283 3 -0.58 3 -0.58

11 14 -0.82 10 -0.492 3 -0.99 3 -0.99

14 0 100.00 13 -0.512 1 0.11 1 0.110 0 - 2 -100

66 63 -0.54 55 -0.41 2 -1.28 1 -0.580 0 100.00 0 1001 0 100.00 0 1003 1 0.52 0 1000 1 -100.00 0 00 0 - 0 00 2 -100.00 0 00 0 100.00 0 1000 0 - 0 05 5 -0.58 4 -0.366 5 -0.40 6 -0.587 6 -0.43 7 -0.58

24 27 -0.70 20 -0.45 5 -0.58 4 -0.362 5 -1.50 4 -1.28

13 12 -0.50 11 -0.427 7 -0.58 6 -0.439 6 -0.18 7 -0.337 7 -0.58 5 -0.251 0 - 2 -1.28

24 24 -0.58 20 -0.427 25 -0.51 19 -0.2311 11 -0.58 9 -0.383 2 -0.18 2 -0.18

14 18 -0.83 23 -1.086 5 -0.40 7 -0.74

14 23 -1.08 19 -0.8964 45 -0.23 51 -0.363 3 -0.58 2 -0.18

10 8 -0.36 5 0.117 4 -0.02 6 -0.43

Sheet1

19 13 -0.20 11 -0.044 4 -0.58 4 -0.582 1 0.11 0 1006 6 -0.58 4 -0.185 4 -0.36 3 -0.07

10 14 -0.92 10 -0.585 7 -0.92 6 -0.773 4 -0.87 4 -0.87

14 17 -0.78 14 -0.5812 11 -0.50 13 -0.6616 23 -0.95 20 -0.8116 16 -0.58 15 -0.524 4 -0.58 3 -0.293 2 -0.18 3 -0.58

42 25 -0.06 35 -0.41 2 -1.28 1 -0.587 5 -0.25 4 -0.023 0 100.00 0 100

33 23 -0.22 25 -0.3163 62 -0.57 118 -1.227 5 -0.25 8 -0.727 6 -0.43 5 -0.254 3 -0.29 2 0.118 6 -0.29 7 -0.453 6 -1.28 2 -0.181 3 -1.68 5 -2.193 2 -0.18 1 0.520 0 100.00 0 1000 0 - 1 -1002 1 0.11 1 0.11

20 13 -0.15 24 -0.7715 1 2.13 213 -3.263 5 -1.09 3 -0.580 3 -100.00 1 -1005 6 -0.76 4 -0.362 2 -0.58 0 1003 1 0.52 1 0.520 1 -100.00 1 -1005 8 -1.05 9 -1.176 9 -0.99 8 -0.871 0 100.00 0 1008 8 -0.58 7 -0.453 1 0.52 2 -0.182 2 -0.58 2 -0.584 1 0.80 0 1009 5 0.01 4 0.23

10 11 -0.68 11 -0.681 1 -0.58 1 -0.581 3 -1.68 2 -1.28

12 7 -0.04 7 -0.047 9 -0.83 4 -0.027 8 -0.72 5 -0.250 0 - 0 00 2 -100.00 1 -1001 1 -0.58 1 -0.582 3 -0.99 1 0.113 3 -0.58 0 100

Sheet1

1 1 -0.58 1 -0.581 0 100.00 0 100

33 3 1.82 6 1.120 0 - 1 -1001 2 -1.28 2 -1.281 1 -0.58 5 -2.19

24 26 -0.66 21 -0.452 2 -0.58 2 -0.589 15 -1.09 12 -0.871 1 -0.58 1 -0.581 0 100.00 1 -0.581 3 -1.68 2 -1.282 2 -0.58 2 -0.581 2 -1.28 2 -1.281 1 -0.58 3 -1.680 0 - 0 01 0 100.00 0 1000 0 - 0 01 1 -0.58 0 00 1 -100.00 2 -1000 1 -100.00 0 04 1 0.80 0 1000 0 - 0 01 1 -0.58 2 -1.280 0 - 0 03 3 -0.58 4 -0.875 4 -0.36 2 0.331 1 -0.58 1 -0.582 2 -0.58 2 -0.581 0 100.00 0 1001 0 100.00 2 -1.286 7 -0.74 8 -0.870 0 - 1 -1001 1 -0.58 2 -1.281 2 -1.28 1 -0.58

30 22 -0.27 41 -0.95 7 -0.92 6 -0.771 0 100.00 0 100

13 16 -0.79 20 -1.014 2 0.11 2 0.111 0 100.00 0 1000 0 - 0 00 0 - 1 -1000 0 - 0 04 5 -0.81 6 -0.990 0 - 1 -1002 2 -0.58 4 -1.281 0 100.00 1 -0.580 0 100.00 0 1005 2 0.33 5 -0.583 6 -1.28 3 -0.583 3 -0.58 1 0.524 3 -0.29 4 -0.585 9 -1.17 8 -1.05

14 18 -0.83 16 -0.726 6 -0.58 4 -0.18

17 17 -0.58 17 -0.58

Sheet1

7 3 0.27 3 0.261 2 -1.28 1 -0.580 0 100.00 2 -1001 3 -1.68 1 -0.583 5 -1.09 2 -0.182 2 -0.58 2 -0.581 1 -0.58 1 -0.580 0 - 0 0

21 19 -0.48 12 -0.021 0 100.00 1 -0.581 2 -1.28 2 -1.281 0 100.00 0 1002 3 -0.99 2 -0.584 0 100.00 1 0.81 1 -0.58 1 -0.581 2 -1.28 2 -1.282 2 -0.58 0 1008 6 -0.29 4 0.118 11 -0.90 8 -0.58

27 30 -0.69 28 -0.626 6 -0.58 7 -0.746 7 -0.74 5 -0.4

20 20 -0.58 20 -0.5818 15 -0.40 16 -0.477 8 -0.72 8 -0.724 6 -0.99 7 -1.143 4 -0.87 3 -0.583 3 -0.58 3 -0.580 1 -100.00 0 03 2 -0.18 3 -0.58

10 8 -0.36 12 -0.770 0 - 0 00 1 -100.00 1 -1000 1 -100.00 4 -1001 0 100.00 2 -1.282 4 -1.28 3 -0.992 1 0.11 0 100

15 13 -0.44 15 -0.582 3 -0.99 3 -0.991 2 -1.28 3 -1.680 3 -100.00 0 0

16 31 -1.25 84 -2.250 0 - 0 02 0 100.00 6 -1.683 3 -0.58 1 0.520 0 - 2 -1004 2 0.11 2 0.110 0 - 2 -1000 1 -100.00 0 03 3 -0.58 2 -0.182 1 0.11 1 0.116 9 -0.99 8 -0.871 1 -0.58 2 -1.283 3 -0.58 3 -0.581 2 -1.28 1 -0.580 0 - 0 02 2 -0.58 5 -1.5

Sheet1

1 1 -0.58 1 -0.582 1 0.11 1 0.111 0 100.00 1 -0.581 1 -0.58 1 -0.581 1 -0.58 1 -0.582 2 -0.58 2 -0.581 1 -0.58 2 -1.280 0 - 1 -1001 0 100.00 0 1001 0 - 1 -0.580 1 -100.00 0 00 0 - 1 -1003 1 0.52 2 -0.185 5 -0.58 3 -0.071 0 100.00 1 -0.584 4 -0.58 3 -0.295 4 -0.36 4 -0.360 1 -100.00 2 -100

10 10 -0.58 7 -0.2322 24 -0.67 41 -1.213 4 -0.87 5 -1.09

13 5 0.37 6 0.191 0 100.00 1 -0.582 2 -0.58 1 0.112 2 -0.58 1 0.110 0 - 1 -1001 0 - 1 -0.580 0 - 0 04 4 -0.58 3 -0.292 1 0.11 2 -0.580 0 100.00 1 -1000 1 -100.00 1 -1000 0 - 1 -1002 3 -0.99 3 -0.992 1 0.11 2 -0.582 2 -0.58 2 -0.585 8 -1.05 6 -0.771 1 -0.58 1 -0.581 0 100.00 1 -0.581 5 -2.19 3 -1.681 1 -0.58 1 -0.580 0 - 0 02 1 0.11 2 -0.58

11 16 -0.96 15 -0.891 1 -0.58 0 1005 6 -0.76 5 -0.587 6 -0.43 7 -0.583 1 0.52 1 0.52

46 44 -0.54 60 -0.852 4 -1.28 2 -0.58

18 17 -0.53 16 -0.471 0 100.00 1 -0.581 1 -0.58 1 -0.581 5 -2.19 2 -1.28

19 17 -0.47 22 -0.731 1 -0.58 1 -0.580 0 100.00 1 -100

Sheet1

1 1 -0.58 0 01 3 -1.68 3 -1.683 2 -0.18 1 0.52

14 8 -0.02 5 0.450 1 -100.00 0 03 4 -0.87 3 -0.58

55 78 -0.94 61 -0.690 0 - 0 00 0 - 0 00 0 - 0 0

12 9 -0.29 8 -0.185 4 -0.36 25 -2.191 0 100.00 1 -0.582 2 -0.58 1 0.110 0 - 0 00 0 - 0 01 1 -0.58 1 -0.581 0 100.00 1 -0.583 4 -0.87 2 -0.183 5 -1.09 5 -1.09

13 9 -0.21 6 0.196 8 -0.87 5 -0.4

32 34 -0.64 27 -0.412 1 0.11 1 0.110 0 - 1 -1001 0 100.00 0 1003 2 -0.18 2 -0.181 0 100.00 0 1000 2 -100.00 0 01 0 100.00 0 1005 3 -0.07 3 -0.072 1 0.11 2 -0.583 1 0.52 5 -1.090 1 -100.00 0 00 0 - 0 02 1 0.11 3 -0.990 1 -100.00 0 00 0 - 0 00 0 - 0 03 2 -0.18 0 1001 1 -0.58 1 -0.581 0 100.00 1 -0.584 2 0.11 2 0.112 6 -1.68 2 -0.588 14 -1.14 11 -0.91 1 -0.58 3 -1.681 0 100.00 0 1000 0 - 0 00 1 -100.00 3 -1002 7 -1.84 5 -1.50 1 -100.00 0 00 0 - 0 02 1 0.11 0 1000 1 -100.00 0 05 7 -0.92 4 -0.360 0 - 0 01 0 100.00 0 100

Sheet1

1 1 -0.58 2 -1.281 1 -0.58 1 -0.58

21 7 0.52 11 0.060 0 - 0 06 8 -0.87 6 -0.581 0 100.00 0 1000 0 100.00 0 1000 0 - 0 01 0 100.00 0 1001 1 -0.58 1 -0.582 2 -0.58 1 0.110 0 - 0 00 2 -100.00 0 01 1 -0.58 1 -0.58

12 13 -0.66 13 -0.660 0 - 0 05 2 0.33 3 -0.077 3 0.27 3 0.264 8 -1.28 5 -0.811 3 -1.68 4 -1.975 4 -0.36 3 -0.073 2 -0.18 2 -0.180 0 100.00 0 1002 0 100.00 0 1000 0 - 1 -1001 0 100.00 0 1004 5 -0.81 5 -0.816 4 -0.18 4 -0.180 1 -100.00 1 -1007 6 -0.43 10 -0.942 2 -0.58 3 -0.992 1 0.11 1 0.110 1 -100.00 2 -1000 1 -100.00 2 -1001 4 -1.97 2 -1.282 2 -0.58 1 0.114 4 -0.58 4 -0.580 2 -100.00 2 -1000 1 -100.00 0 03 10 -1.79 1 0.521 1 -0.58 2 -1.289 8 -0.46 7 -0.332 2 -0.58 2 -0.584 4 -0.58 4 -0.581 3 -1.68 1 -0.580 1 -100.00 1 -1005 2 0.33 2 0.333 3 -0.58 2 -0.181 1 -0.58 0 02 1 0.11 4 -1.28

25 13 0.07 14 00 1 -100.00 0 02 1 0.11 1 0.113 2 -0.18 3 -0.585 5 -0.58 4 -0.364 4 -0.58 11 -1.61 1 -0.58 1 -0.58

Sheet1

0 1 -100.00 0 05 2 0.33 2 0.331 1 -0.58 0 1002 4 -1.28 5 -1.54 3 -0.29 1 0.80 0 - 0 00 1 -100.00 0 04 5 -0.81 16 -1.970 0 - 0 04 4 -0.58 5 -0.813 1 0.52 1 0.52

10 17 -1.11 11 -0.681 1 -0.58 1 -0.581 1 -0.58 1 -0.581 1 -0.58 1 -0.58

32 18 -0.01 16 0.115 5 -0.58 5 -0.582 1 0.11 1 0.117 9 -0.83 10 -0.941 0 100.00 0 1005 5 -0.58 4 -0.363 2 -0.18 3 -0.586 4 -0.18 4 -0.186 5 -0.40 7 -0.743 4 -0.87 6 -1.28

37 30 -0.37 52 -0.934 4 -0.58 3 -0.290 1 -100.00 0 01 1 -0.58 0 100

51 65 -0.83 50 -0.571 1 -0.58 3 -1.688 7 -0.45 6 -0.293 2 -0.18 1 0.524 3 -0.29 4 -0.585 4 -0.36 4 -0.361 2 -1.28 3 -1.681 1 -0.58 1 -0.581 1 -0.58 2 -1.281 2 -1.28 1 -0.583 3 -0.58 3 -0.582 2 -0.58 1 0.111 3 -1.68 1 -0.581 1 -0.58 1 -0.583 0 100.00 1 0.52

35 24 -0.21 17 0.1416 5 0.58 8 0.113 3 -0.58 7 -1.435 5 -0.58 3 -0.071 0 100.00 0 1004 3 -0.29 3 -0.292 1 0.11 1 0.110 0 - 0 08 8 -0.58 9 -0.71 1 -0.58 1 -0.581 0 100.00 1 -0.587 7 -0.58 7 -0.580 0 - 0 0

Sheet1

1 2 -1.28 1 -0.584 4 -0.58 4 -0.584 5 -0.81 4 -0.581 1 -0.58 1 -0.580 1 -100.00 0 0

11 8 -0.26 11 -0.585 2 0.33 3 -0.071 1 -0.58 2 -1.285 11 -1.37 5 -0.581 1 -0.58 2 -1.281 3 -1.68 1 -0.582 4 -1.28 2 -0.581 2 -1.28 4 -1.971 2 -1.28 0 1002 5 -1.50 3 -0.992 2 -0.58 2 -0.580 0 - 1 -100

10 9 -0.48 12 -0.771 2 -1.28 2 -1.280 1 -100.00 0 1002 1 0.11 2 -0.58

21 23 -0.67 22 -0.6317 16 -0.52 19 -0.690 0 - 0 01 2 -1.28 2 -1.286 6 -0.58 6 -0.581 2 -1.28 1 -0.580 0 100.00 0 1000 1 -100.00 1 -1001 1 -0.58 1 -0.581 1 -0.58 1 -0.587 8 -0.72 11 -1.043 2 -0.18 1 0.521 2 -1.28 1 -0.582 1 0.11 1 0.111 3 -1.68 0 100

26 13 0.11 11 0.280 0 - 0 09 7 -0.33 4 0.231 1 -0.58 2 -1.28

20 15 -0.29 16 -0.361 0 - 8 -2.660 1 -100.00 1 -1002 1 0.11 2 -0.581 1 -0.58 0 1000 0 - 0 02 4 -1.28 10 -2.19

27 33 -0.78 38 -0.931 1 -0.58 0 100

16 14 -0.45 11 -0.212 1 0.11 1 0.111 1 -0.58 1 -0.581 1 -0.58 1 -0.587 11 -1.03 11 -1.042 4 -1.28 5 -1.52 1 0.11 1 0.110 0 - 0 0

Sheet1

2 4 -1.28 1 0.110 0 - 0 05 5 -0.58 7 -0.922 1 0.11 1 0.110 1 -100.00 0 01 1 -0.58 1 -0.583 1 0.52 1 0.524 5 -0.81 6 -0.991 0 - 2 -1.282 3 -0.99 1 0.112 2 -0.58 1 0.113 3 -0.58 6 -1.281 1 -0.58 1 -0.580 2 -100.00 1 -1000 1 -100.00 0 00 1 -100.00 1 -1004 4 -0.58 3 -0.292 2 -0.58 1 0.112 2 -0.58 2 -0.588 10 -0.81 10 -0.810 0 - 1 -1002 2 -0.58 1 0.110 0 - 1 -1002 1 0.11 2 -0.58

10 7 -0.23 4 0.332 1 0.11 1 0.11

20 17 -0.42 16 -0.369 16 -1.16 13 -0.95

15 18 -0.77 22 -0.9711 11 -0.58 4 0.432 1 0.11 1 0.118 10 -0.81 3 0.43 4 -0.87 4 -0.876 9 -0.99 9 -0.991 1 -0.58 1 -0.581 0 100.00 0 1000 1 -100.00 0 04 5 -0.81 3 -0.291 1 -0.58 1 -0.582 1 0.11 9 -2.091 2 -1.28 1 -0.580 0 - 0 00 1 -100.00 1 -1001 0 100.00 0 1000 0 - 0 04 7 -1.14 5 -0.813 1 0.52 1 0.522 1 0.11 1 0.112 2 -0.58 1 0.110 0 100.00 0 1007 4 -0.02 4 -0.023 1 0.52 1 0.525 7 -0.92 2 0.330 1 -100.00 0 02 1 0.11 1 0.110 2 -100.00 0 06 5 -0.40 4 -0.18

Sheet1

2 1 0.11 1 0.112 1 0.11 3 -0.992 2 -0.58 1 0.116 8 -0.87 4 -0.182 1 0.11 1 0.112 1 0.11 1 0.112 1 0.11 1 0.110 0 - 1 -1004 4 -0.58 3 -0.299 2 0.92 2 0.922 1 0.11 1 0.112 1 0.11 1 0.115 3 -0.07 2 0.331 1 -0.58 1 -0.583 1 0.52 4 -0.87

11 12 -0.67 11 -0.583 5 -1.09 3 -0.581 2 -1.28 1 -0.58

58 60 -0.62 78 -0.882 3 -0.99 2 -0.582 2 -0.58 2 -0.583 3 -0.58 2 -0.180 1 -100.00 0 01 0 100.00 0 1001 0 100.00 0 1000 1 -100.00 1 -1001 1 -0.58 1 -0.581 1 -0.58 2 -1.282 0 - 0 00 0 - 0 02 1 0.11 1 0.112 1 0.11 1 0.111 2 -1.28 1 -0.580 1 -100.00 1 -1008 7 -0.45 9 -0.71 1 -0.58 1 -0.58

13 8 -0.10 10 -0.322 1 0.11 5 -1.50 0 - 0 01 1 -0.58 1 -0.581 0 100.00 0 1001 6 -2.37 2 -1.281 2 -1.28 2 -1.28

13 8 -0.10 7 0.040 0 - 1 -1004 2 0.11 3 -0.291 2 -1.28 1 -0.581 1 -0.58 2 -1.285 7 -0.92 5 -0.580 0 - 0 00 1 -100.00 1 -1004 4 -0.58 5 -0.811 0 100.00 1 -0.580 1 -100.00 0 00 0 - 0 02 1 0.11 2 -0.580 0 - 1 -100

Sheet1

1 0 100.00 0 1004 1 0.80 6 -0.991 0 100.00 1 -0.581 0 - 0 01 0 - 0 03 2 -0.18 1 0.523 0 100.00 2 -0.183 2 -0.18 4 -0.870 0 - 1 -1001 5 -2.19 2 -1.281 0 100.00 0 1001 1 -0.58 0 1000 0 - 1 -1001 1 -0.58 1 -0.580 0 - 0 03 4 -0.87 4 -0.874 2 0.11 0 100

11 8 -0.26 10 -0.491 0 100.00 2 -1.280 0 100.00 0 1000 0 - 1 -1002 1 0.11 1 0.111 3 -1.68 1 -0.58

20 15 -0.29 24 -0.777 4 -0.02 6 -0.431 3 -1.68 5 -2.19

11 11 -0.58 7 -0.130 0 - 0 00 0 - 0 01 0 100.00 0 1002 1 0.11 2 -0.580 1 -100.00 1 -1000 0 100.00 0 1000 1 -100.00 0 01 0 100.00 0 1005 16 -1.75 0 1001 1 -0.58 0 100

40 27 -0.19 31 -0.331 0 100.00 0 1002 5 -1.50 1 0.110 2 -100.00 1 -1003 2 -0.18 1 0.521 0 100.00 1 -0.585 5 -0.58 5 -0.58

62 54 -0.45 78 -0.821 0 - 0 01 1 -0.58 0 1000 0 - 0 00 0 - 0 00 0 - 0 02 2 -0.58 0 1001 2 -1.28 1 -0.58

12 7 -0.04 6 0.110 0 100.00 0 1002 1 0.11 1 0.110 0 - 0 01 0 - 1 -0.58

Sheet1

0 1 -100.00 0 07 6 -0.43 7 -0.583 4 -0.87 6 -1.28

17 15 -0.46 8 0.1711 7 -0.13 8 -0.262 1 0.11 3 -0.991 2 -1.28 3 -1.683 20 -2.48 42 -3.232 3 -0.99 6 -1.681 2 -1.28 0 1006 10 -1.09 10 -1.09

18 17 -0.53 15 -0.49 5 0.01 5 0.014 4 -0.58 2 0.110 2 -100.00 1 -1008 8 -0.58 6 -0.291 1 -0.58 1 -0.581 1 -0.58 1 -0.587 11 -1.03 10 -0.941 0 100.00 0 1003 7 -1.43 6 -1.286 6 -0.58 7 -0.741 2 -1.28 1 -0.582 2 -0.58 1 0.117 10 -0.94 7 -0.582 2 -0.58 1 0.114 4 -0.58 2 0.112 3 -0.99 4 -1.285 5 -0.58 5 -0.580 1 -100.00 0 1000 0 - 0 00 0 - 0 09 15 -1.09 17 -1.222 2 -0.58 1 0.11

16 18 -0.70 18 -0.76 7 -0.74 7 -0.749 5 0.01 3 0.529 6 -0.18 6 -0.18

14 9 -0.14 11 -0.345 5 -0.58 4 -0.36

16 10 -0.11 21 -0.862 2 -0.58 2 -0.58

25 13 0.07 15 -0.073 4 -0.87 4 -0.873 1 0.52 4 -0.87

18 13 -0.26 16 -0.478 9 -0.70 9 -0.70 0 - 0 02 2 -0.58 1 0.116 12 -1.28 12 -1.28

15 21 -0.92 24 -1.052 1 0.11 0 1001 0 100.00 0 1005 5 -0.58 5 -0.582 0 - 0 01 2 -1.28 2 -1.283 0 100.00 2 -0.18

Sheet1

0 0 - 0 02 2 -0.58 2 -0.58

20 13 -0.15 10 0.112 2 -0.58 1 0.113 5 -1.09 4 -0.87

13 10 -0.32 8 -0.13 4 -0.87 6 -1.282 2 -0.58 0 1004 4 -0.58 4 -0.581 4 -1.97 5 -2.194 4 -0.58 4 -0.580 0 - 2 -1002 0 100.00 0 1001 1 -0.58 1 -0.583 2 -0.18 1 0.526 3 0.11 4 -0.180 1 -100.00 0 00 0 - 1 -1002 1 0.11 1 0.114 4 -0.58 2 0.111 1 -0.58 0 1006 5 -0.40 5 -0.46 5 -0.40 5 -0.43 3 -0.58 3 -0.583 3 -0.58 2 -0.18

26 24 -0.50 28 -0.662 1 0.11 3 -0.990 1 -100.00 0 0

23 26 -0.71 33 -0.9515 14 -0.51 14 -0.511 1 -0.58 0 1001 1 -0.58 0 1003 2 -0.18 1 0.52

21 24 -0.72 19 -0.4840 35 -0.45 43 -0.661 1 -0.58 0 100

19 13 -0.20 4 0.980 0 100.00 0 1000 1 -100.00 0 04 5 -0.81 4 -0.580 0 - 0 02 3 -0.99 3 -0.992 3 -0.99 1 0.111 1 -0.58 0 1001 2 -1.28 1 -0.584 5 -0.81 10 -1.51 1 -0.58 1 -0.582 4 -1.28 3 -0.990 0 - 1 -1000 0 - 0 01 2 -1.28 0 1000 0 - 0 00 4 -100.00 1 -1003 2 -0.18 2 -0.187 6 -0.43 5 -0.250 0 - 1 -1000 0 - 0 0

Sheet1

0 0 100.00 0 1000 1 -100.00 1 -100

13 6 0.19 5 0.372 0 100.00 1 0.11

14 12 -0.43 14 -0.584 3 -0.29 3 -0.292 3 -0.99 1 0.117 6 -0.43 3 0.260 1 -100.00 0 07 3 0.27 5 -0.25

13 9 -0.21 14 -0.661 2 -1.28 1 -0.580 0 - 0 00 0 - 0 00 0 - 3 -1000 0 - 0 01 1 -0.58 1 -0.589 4 0.23 5 0.016 10 -1.09 6 -0.583 6 -1.28 5 -1.091 1 -0.58 0 03 0 100.00 2 -0.180 0 - 1 -1002 1 0.11 0 1000 1 -100.00 0 0

11 13 -0.75 11 -0.582 5 -1.50 2 -0.586 5 -0.40 5 -0.42 2 -0.58 2 -0.580 0 - 0 01 0 100.00 0 1007 13 -1.20 10 -0.941 3 -1.68 7 -2.532 0 100.00 4 -1.283 2 -0.18 4 -0.870 1 -100.00 0 08 9 -0.70 9 -0.71 0 100.00 0 1004 4 -0.58 4 -0.582 3 -0.99 2 -0.58

18 17 -0.53 12 -0.181 1 -0.58 1 -0.581 0 100.00 0 1000 0 100.00 0 100

24 36 -0.99 42 -1.151 0 - 0 05 7 -0.92 7 -0.924 11 -1.59 4 -0.580 0 - 0 0

12 15 -0.81 14 -0.741 1 -0.58 1 -0.581 2 -1.28 1 -0.583 2 -0.18 2 -0.189 6 -0.18 6 -0.181 1 -0.58 1 -0.587 13 -1.20 15 -1.354 5 -0.81 4 -0.58

Sheet1

3 2 -0.18 4 -0.873 10 -1.79 8 -1.563 2 -0.18 3 -0.581 1 -0.58 2 -1.282 2 -0.58 2 -0.58

18 15 -0.40 18 -0.584 2 0.11 3 -0.290 0 - 0 0

46 36 -0.34 37 -0.373 2 -0.18 1 0.52

49 0 100.00 10 1.011 0 100.00 1 -0.581 0 100.00 0 1008 8 -0.58 6 -0.291 0 100.00 0 1003 1 0.52 1 0.520 0 - 0 01 2 -1.28 0 1000 0 - 0 00 0 100.00 0 1002 2 -0.58 2 -0.581 2 -1.28 1 -0.582 0 100.00 0 1002 0 100.00 0 1000 1 -100.00 0 02 1 0.11 0 1003 1 0.52 1 0.52

19 19 -0.58 34 -1.17101 108 -0.65 132 -0.8664 61 -0.54 56 -0.451 1 -0.58 0 1002 1 0.11 1 0.111 2 -1.28 2 -1.280 0 - 0 00 0 - 0 00 1 -100.00 0 01 4 -1.97 5 -2.192 1 0.11 1 0.111 0 100.00 0 1001 1 -0.58 1 -0.582 3 -0.99 1 0.110 1 -100.00 1 -1001 1 -0.58 3 -1.68

12 16 -0.87 14 -0.742 0 - 0 02 2 -0.58 1 0.110 0 - 0 00 4 -100.00 2 -100

15 18 -0.77 16 -0.651 0 100.00 1 -0.582 0 100.00 2 -0.587 3 0.27 4 -0.020 0 - 0 00 0 - 0 01 0 - 1 -0.580 1 -100.00 0 05 3 -0.07 4 -0.36

Sheet1

4 4 -0.58 5 -0.810 1 -100.00 0 00 1 -100.00 0 1000 0 - 0 01 0 - 1 -0.58

10 7 -0.23 3 0.620 0 - 0 03 0 100.00 1 0.52

14 13 -0.51 11 -0.345 1 1.03 3 -0.070 0 - 0 02 0 100.00 1 0.112 1 0.11 1 0.118 11 -0.90 7 -0.45

43 54 -0.81 53 -0.791 0 100.00 1 -0.585 4 -0.36 3 -0.079 7 -0.33 3 0.52

12 8 -0.18 7 -0.041 1 -0.58 1 -0.583 2 -0.18 2 -0.182 3 -0.99 2 -0.583 3 -0.58 2 -0.183 0 100.00 1 0.526 11 -1.19 5 -0.44 2 0.11 3 -0.290 0 - 2 -1003 2 -0.18 1 0.520 0 - 0 00 1 -100.00 1 -100

18 18 -0.58 16 -0.470 0 - 1 -1001 1 -0.58 1 -0.582 2 -0.58 0 100

16 14 -0.45 16 -0.581 0 100.00 3 -1.680 0 100.00 0 1004 2 0.11 6 -0.990 0 - 0 05 5 -0.58 4 -0.365 3 -0.07 7 -0.920 0 - 0 01 0 - 0 0

14 16 -0.72 17 -0.784 3 -0.29 3 -0.296 8 -0.87 9 -0.992 1 0.11 3 -0.990 0 - 0 00 2 -100.00 1 -1000 1 -100.00 0 03 2 -0.18 1 0.522 1 0.11 2 -0.583 2 -0.18 1 0.524 4 -0.58 5 -0.810 0 - 1 -1002 4 -1.28 3 -0.99

26 20 -0.32 34 -0.85

Sheet1

2 3 -0.99 3 -0.991 1 -0.58 1 -0.584 2 0.11 2 0.11

17 5 0.64 11 -0.152 0 100.00 2 -0.582 4 -1.28 2 -0.582 0 100.00 1 0.11

10 8 -0.36 7 -0.232 2 -0.58 3 -0.99

22 18 -0.38 21 -0.543 4 -0.87 3 -0.581 0 100.00 0 1000 0 - 0 02 3 -0.99 2 -0.588 5 -0.11 4 0.114 0 100.00 1 0.81 1 -0.58 2 -1.280 1 -100.00 1 -1001 1 -0.58 2 -1.281 1 -0.58 1 -0.581 2 -1.28 2 -1.281 2 -1.28 1 -0.580 2 -100.00 1 -1005 2 0.33 2 0.333 2 -0.18 1 0.520 0 - 0 01 2 -1.28 2 -1.281 2 -1.28 9 -2.780 0 - 0 00 0 - 0 00 0 100.00 1 -1001 3 -1.68 3 -1.681 0 100.00 0 1003 2 -0.18 1 0.521 0 100.00 4 -1.970 0 - 1 -1002 0 100.00 0 1003 3 -0.58 4 -0.875 1 1.03 6 -0.771 2 -1.28 1 -0.583 6 -1.28 6 -1.281 0 100.00 0 1000 1 -100.00 0 01 1 -0.58 1 -0.581 0 100.00 0 1000 0 - 0 01 2 -1.28 1 -0.583 2 -0.18 3 -0.585 2 0.33 7 -0.921 1 -0.58 1 -0.580 0 - 0 01 0 100.00 0 1000 0 - 1 -1000 0 100.00 0 1003 2 -0.18 1 0.520 0 - 2 -1000 0 - 0 0

Sheet1

4 2 0.11 3 -0.296 8 -0.87 8 -0.871 0 100.00 0 1007 7 -0.58 7 -0.582 0 100.00 1 0.112 3 -0.99 4 -1.280 0 - 0 07 11 -1.03 10 -0.940 1 -100.00 0 05 7 -0.92 4 -0.364 6 -0.99 2 0.112 2 -0.58 4 -1.283 0 100.00 0 1000 0 - 0 04 5 -0.81 13 -1.761 1 -0.58 1 -0.580 0 - 1 -1002 2 -0.58 3 -0.990 1 -100.00 0 05 4 -0.36 5 -0.584 5 -0.81 4 -0.585 3 -0.07 4 -0.360 0 - 0 02 1 0.11 1 0.111 1 -0.58 1 -0.581 4 -1.97 3 -1.681 1 -0.58 2 -1.280 0 100.00 0 1001 1 -0.58 0 1003 2 -0.18 2 -0.180 0 - 0 01 2 -1.28 1 -0.582 3 -0.99 6 -1.681 0 - 0 02 2 -0.58 0 1006 5 -0.40 5 -0.41 1 -0.58 1 -0.584 0 100.00 2 0.110 0 100.00 0 1000 0 - 0 00 0 - 0 01 0 100.00 0 1001 2 -1.28 2 -1.281 3 -1.68 4 -1.971 1 -0.58 1 -0.581 1 -0.58 1 -0.580 1 -100.00 2 -1000 0 - 0 02 0 100.00 0 1001 1 -0.58 0 1005 5 -0.58 4 -0.364 1 0.80 2 0.110 0 - 1 -1001 2 -1.28 0 1003 1 0.52 1 0.520 0 - 0 00 0 - 1 -100

Sheet1

1 1 -0.58 0 1002 1 0.11 1 0.116 3 0.11 8 -0.872 1 0.11 1 0.111 1 -0.58 1 -0.580 1 -100.00 0 1002 0 100.00 0 1001 2 -1.28 2 -1.280 0 - 1 -1002 1 0.11 1 0.11

14 11 -0.34 19 -0.892 3 -0.99 3 -0.991 1 -0.58 1 -0.583 5 -1.09 6 -1.282 4 -1.28 0 1001 1 -0.58 0 100

34 45 -0.87 45 -0.874 3 -0.29 2 0.111 1 -0.58 1 -0.581 1 -0.58 1 -0.581 2 -1.28 1 -0.580 1 -100.00 1 -1001 0 100.00 0 1001 2 -1.28 0 100

21 25 -0.76 26 -0.80 2 -100.00 1 -1002 3 -0.99 1 0.111 1 -0.58 2 -1.281 1 -0.58 1 -0.581 0 100.00 0 1001 0 100.00 0 1001 1 -0.58 2 -1.28

30 31 -0.62 47 -1.030 0 - 0 00 0 - 0 01 1 -0.58 1 -0.580 0 - 1 -1007 9 -0.83 6 -0.438 8 -0.58 3 0.40 0 - 0 00 0 - 0 01 0 100.00 0 1001 1 -0.58 1 -0.580 0 - 0 03 2 -0.18 3 -0.582 5 -1.50 6 -1.680 2 -100.00 1 -1005 7 -0.92 6 -0.770 2 -100.00 0 00 2 -100.00 1 -1001 1 -0.58 0 1001 1 -0.58 0 1002 3 -0.99 2 -0.580 1 -100.00 0 0

10 6 -0.07 7 -0.235 3 -0.07 5 -0.580 1 -100.00 0 0

Sheet1

3 3 -0.58 4 -0.870 0 - 1 -1000 0 100.00 0 1000 1 -100.00 1 -1000 0 - 0 01 0 - 0 02 4 -1.28 4 -1.280 0 - 0 01 1 -0.58 1 -0.581 2 -1.28 3 -1.682 2 -0.58 1 0.110 0 - 0 01 0 100.00 0 1002 3 -0.99 2 -0.580 1 -100.00 0 01 0 100.00 1 -0.581 3 -1.68 4 -1.974 2 0.11 1 0.80 1 -100.00 0 03 4 -0.87 5 -1.094 7 -1.14 10 -1.50 1 -100.00 1 -1001 1 -0.58 1 -0.584 4 -0.58 5 -0.811 0 100.00 0 1001 0 100.00 0 1004 2 0.11 1 0.80 1 -100.00 1 -1006 3 0.11 4 -0.18

10 5 0.11 7 -0.231 0 100.00 0 1001 0 - 0 00 0 - 1 -1001 0 - 2 -1.283 3 -0.58 1 0.520 0 - 0 01 4 -1.97 1 -0.580 0 - 0 01 0 100.00 0 1001 0 100.00 1 -0.581 2 -1.28 1 -0.583 3 -0.58 2 -0.18

17 8 0.17 13 -0.311 2 -1.28 1 -0.581 0 100.00 1 -0.581 2 -1.28 1 -0.581 0 100.00 0 1001 1 -0.58 2 -1.283 1 0.52 1 0.520 1 -100.00 0 00 0 100.00 0 1002 4 -1.28 1 0.112 2 -0.58 1 0.110 0 - 1 -1000 0 100.00 2 -1000 1 -100.00 0 1000 1 -100.00 0 0

Sheet1

0 0 - 1 -1003 1 0.52 2 -0.181 1 -0.58 2 -1.280 0 - 0 00 0 - 0 00 0 - 0 01 1 -0.58 1 -0.581 0 100.00 0 1001 2 -1.28 2 -1.280 0 - 0 00 0 - 1 -1000 1 -100.00 0 00 0 - 1 -1001 1 -0.58 0 1000 1 -100.00 0 1000 0 - 0 01 1 -0.58 1 -0.581 0 100.00 0 1001 1 -0.58 0 1000 0 - 0 01 3 -1.68 0 1001 2 -1.28 2 -1.280 0 - 0 02 2 -0.58 2 -0.581 0 100.00 0 1000 1 -100.00 0 01 0 100.00 0 1000 1 -100.00 0 06 3 0.11 7 -0.743 2 -0.18 2 -0.181 0 100.00 2 -1.282 2 -0.58 2 -0.583 0 100.00 2 -0.183 3 -0.58 1 0.523 1 0.52 1 0.520 0 - 0 01 1 -0.58 0 1003 0 100.00 2 -0.181 1 -0.58 3 -1.680 1 -100.00 0 00 0 - 0 00 0 - 1 -1003 4 -0.87 2 -0.181 1 -0.58 1 -0.582 2 -0.58 0 1000 0 - 1 -1002 0 100.00 0 1005 3 -0.07 2 0.331 1 -0.58 0 1000 0 - 1 -1002 4 -1.28 1 0.112 2 -0.58 0 1000 0 - 0 05 11 -1.37 6 -0.770 1 -100.00 0 05 4 -0.36 4 -0.362 4 -1.28 4 -1.28

Sheet1

4 3 -0.29 1 0.84 6 -0.99 4 -0.582 2 -0.58 2 -0.587 2 0.67 4 -0.023 3 -0.58 1 0.527 5 -0.25 4 -0.021 4 -1.97 2 -1.280 1 -100.00 1 -1006 5 -0.40 6 -0.587 6 -0.43 10 -0.94

13 11 -0.42 9 -0.212 3 -0.99 2 -0.58

10 6 -0.07 7 -0.232 2 -0.58 1 0.110 0 - 0 00 0 100.00 0 1003 3 -0.58 0 00 0 - 0 02 0 - 0 01 0 100.00 0 1000 0 - 0 00 0 100.00 0 1000 1 -100.00 0 02 1 0.11 3 -0.990 0 - 0 02 0 100.00 1 0.112 2 -0.58 1 0.110 0 - 0 06 5 -0.40 10 -1.096 4 -0.18 8 -0.872 3 -0.99 3 -0.990 5 -100.00 1 -1005 7 -0.92 5 -0.582 1 0.11 1 0.11

11 11 -0.58 6 0.021 2 -1.28 1 -0.586 5 -0.40 12 -1.282 2 -0.58 2 -0.587 9 -0.83 7 -0.584 1 0.80 1 0.8

23 21 -0.49 20 -0.442 2 -0.58 2 -0.587 9 -0.83 4 -0.024 3 -0.29 3 -0.292 2 -0.58 2 -0.583 2 -0.18 3 -0.581 0 - 0 05 5 -0.58 3 -0.072 1 0.11 2 -0.583 2 -0.18 2 -0.184 4 -0.58 4 -0.581 0 100.00 1 -0.584 5 -0.81 6 -0.993 2 -0.18 1 0.52

14 16 -0.72 11 -0.341 1 -0.58 2 -1.280 0 - 0 0

Sheet1

5 2 0.33 2 0.331 0 100.00 0 1002 1 0.11 1 0.115 5 -0.58 6 -0.776 7 -0.74 5 -0.40 0 - 0 06 7 -0.74 5 -0.41 0 100.00 2 -1.283 4 -0.87 3 -0.58

29 25 -0.43 14 0.150 0 - 6 -1005 4 -0.36 2 0.332 2 -0.58 2 -0.58

10 14 -0.92 15 -0.990 0 100.00 0 1000 0 - 0 01 0 100.00 1 -0.585 4 -0.36 5 -0.585 5 -0.58 8 -1.057 14 -1.28 7 -0.580 0 - 0 02 5 -1.50 2 -0.580 0 - 0 01 0 100.00 2 -1.281 1 -0.58 1 -0.58

15 23 -1.01 17 -0.710 1 -100.00 1 -1003 2 -0.18 0 1002 2 -0.58 5 -1.51 2 -1.28 3 -1.68

14 14 -0.58 16 -0.720 0 - 0 06 4 -0.18 9 -0.992 1 0.11 2 -0.580 0 - 0 00 1 -100.00 0 00 0 - 0 00 0 - 0 03 4 -0.87 1 0.521 1 -0.58 2 -1.28

27 18 -0.18 14 0.070 0 - 0 01 1 -0.58 1 -0.584 5 -0.81 2 0.110 0 - 0 08 3 0.40 7 -0.454 5 -0.81 6 -0.991 0 100.00 0 1001 2 -1.28 1 -0.582 1 0.11 3 -0.990 0 - 0 01 2 -1.28 3 -1.682 3 -0.99 4 -1.281 1 -0.58 1 -0.581 2 -1.28 1 -0.583 1 0.52 0 1000 0 - 1 -100

Sheet1

3 1 0.52 1 0.521 0 100.00 1 -0.580 0 - 0 01 0 100.00 0 1001 2 -1.28 0 01 1 -0.58 1 -0.581 1 -0.58 1 -0.580 0 100.00 0 1000 1 -100.00 0 01 2 -1.28 1 -0.582 6 -1.68 19 -2.841 0 100.00 0 1000 0 - 0 01 1 -0.58 0 1006 3 0.11 3 0.110 0 100.00 0 1001 0 - 1 -0.582 2 -0.58 2 -0.580 0 - 0 00 0 - 0 01 0 - 0 00 1 -100.00 0 04 4 -0.58 7 -1.142 2 -0.58 3 -0.991 3 -1.68 1 -0.581 1 -0.58 1 -0.580 0 100.00 0 1001 0 100.00 1 -0.584 0 100.00 0 1003 1 0.52 1 0.524 3 -0.29 3 -0.293 2 -0.18 3 -0.584 1 0.80 3 -0.290 1 -100.00 0 00 0 100.00 0 1000 0 100.00 0 1002 2 -0.58 4 -1.280 0 - 0 00 0 100.00 0 1001 2 -1.28 1 -0.580 0 - 0 00 0 - 0 00 0 - 0 00 0 - 0 07 7 -0.58 7 -0.580 0 - 0 00 1 -100.00 0 1000 0 - 0 01 1 -0.58 0 1004 5 -0.81 5 -0.811 0 100.00 1 -0.581 3 -1.68 2 -1.282 1 0.11 2 -0.580 2 -100.00 0 03 2 -0.18 2 -0.180 0 - 1 -100

12 13 -0.66 10 -0.4

Sheet1

1 0 - 0 01 1 -0.58 0 1000 0 - 1 -1001 1 -0.58 1 -0.581 3 -1.68 1 -0.580 0 - 0 02 6 -1.68 3 -0.990 0 - 1 -1001 0 - 1 -0.582 3 -0.99 2 -0.58

27 33 -0.78 26 -0.552 0 100.00 2 -0.583 2 -0.18 1 0.521 3 -1.68 0 1001 0 100.00 1 -0.580 0 100.00 0 100

10 11 -0.68 14 -0.928 5 -0.11 7 -0.452 3 -0.99 3 -0.994 2 0.11 2 0.112 1 0.11 1 0.110 0 - 0 01 0 - 0 00 0 - 0 04 4 -0.58 3 -0.294 3 -0.29 3 -0.290 2 -100.00 0 1000 0 - 0 03 1 0.52 0 1003 2 -0.18 1 0.52

15 9 -0.07 10 -0.180 1 -100.00 1 -1001 2 -1.28 0 1000 1 -100.00 1 -1002 0 - 0 03 0 100.00 2 -0.180 1 -100.00 2 -1001 0 100.00 1 -0.58

27 19 -0.23 12 0.230 0 - 0 01 1 -0.58 1 -0.580 0 - 0 00 0 - 0 03 4 -0.87 3 -0.581 1 -0.58 1 -0.582 0 100.00 0 1003 3 -0.58 4 -0.870 1 -100.00 0 00 0 - 0 00 1 -100.00 0 00 0 - 0 00 1 -100.00 0 0

41 51 -0.80 46 -0.70 0 - 0 01 0 100.00 1 -0.580 0 - 0 00 2 -100.00 0 100

Sheet1

0 0 - 0 00 0 - 1 -1000 0 - 0 01 0 100.00 0 100

10 7 -0.23 7 -0.230 0 - 0 01 1 -0.58 1 -0.583 4 -0.87 2 -0.18

12 7 -0.04 4 0.523 1 0.52 1 0.521 2 -1.28 1 -0.581 1 -0.58 0 1001 0 - 0 00 0 - 0 00 0 - 0 01 0 100.00 1 -0.581 1 -0.58 3 -1.688 4 0.11 10 -0.811 1 -0.58 0 00 0 - 0 03 4 -0.87 5 -1.090 0 - 1 -1001 1 -0.58 3 -1.680 2 -100.00 6 -1000 0 - 0 01 1 -0.58 2 -1.281 0 100.00 1 -0.58

11 7 -0.13 6 0.020 0 - 1 -100

45 48 -0.65 49 -0.670 0 - 0 04 4 -0.58 2 0.117 5 -0.25 7 -0.581 0 100.00 1 -0.584 3 -0.29 3 -0.291 0 100.00 0 1000 0 - 0 01 1 -0.58 2 -1.280 0 - 0 0

10 8 -0.36 14 -0.920 1 -100.00 0 00 1 -100.00 0 00 0 - 1 -100

29 28 -0.55 24 -0.391 0 100.00 2 -1.281 1 -0.58 1 -0.582 1 0.11 1 0.111 0 100.00 1 -0.581 1 -0.58 1 -0.580 0 - 0 00 0 - 1 -1007 6 -0.43 8 -0.72

29 38 -0.85 39 -0.886 7 -0.74 5 -0.44 3 -0.29 2 0.111 0 100.00 1 -0.580 0 - 0 0

Sheet1

0 1 -100.00 1 -1000 1 -100.00 0 00 1 -100.00 0 00 0 - 0 00 0 - 0 00 0 - 0 00 0 - 0 00 0 - 1 -1000 0 - 0 01 0 100.00 1 -0.582 2 -0.58 2 -0.581 1 -0.58 2 -1.281 4 -1.97 1 -0.589 11 -0.78 12 -0.871 0 - 0 06 9 -0.99 6 -0.581 0 100.00 0 1001 0 100.00 0 1000 0 - 0 01 1 -0.58 1 -0.581 0 100.00 0 1004 3 -0.29 2 0.110 1 -100.00 0 01 0 100.00 0 1000 0 - 1 -1000 1 -100.00 0 100

52 50 -0.55 44 -0.421 3 -1.68 1 -0.580 0 100.00 0 1001 1 -0.58 0 1003 5 -1.09 8 -1.560 2 -100.00 1 -1002 0 100.00 0 1003 3 -0.58 3 -0.582 0 100.00 1 0.111 0 100.00 0 1001 4 -1.97 3 -1.680 0 - 0 01 0 - 1 -0.580 0 - 1 -1000 0 - 0 01 0 100.00 0 1007 8 -0.72 15 -1.351 1 -0.58 0 1003 0 100.00 0 100

36 41 -0.71 36 -0.583 1 0.52 1 0.520 1 -100.00 0 1000 0 - 1 -1001 0 100.00 0 1001 2 -1.28 2 -1.281 2 -1.28 2 -1.280 1 -100.00 0 00 1 -100.00 0 02 2 -0.58 1 0.112 2 -0.58 1 0.110 0 - 1 -100

Sheet1

0 1 -100.00 0 00 0 - 0 01 0 - 0 01 3 -1.68 1 -0.582 0 100.00 1 0.111 0 100.00 2 -1.280 1 -100.00 1 -1000 1 -100.00 0 1000 0 - 1 -1000 0 - 0 09 3 0.52 4 0.230 1 -100.00 0 00 1 -100.00 0 01 1 -0.58 1 -0.580 0 - 1 -1000 0 - 0 03 1 0.52 1 0.521 2 -1.28 1 -0.580 0 - 1 -1008 4 0.11 10 -0.811 2 -1.28 4 -1.970 0 - 1 -1000 0 - 1 -1001 0 100.00 0 1000 0 - 0 00 0 - 1 -1002 2 -0.58 1 0.110 0 - 0 01 2 -1.28 1 -0.581 1 -0.58 1 -0.584 0 100.00 1 0.81 1 -0.58 2 -1.280 1 -100.00 0 01 0 - 0 00 0 - 1 -1000 0 - 0 00 0 - 0 01 0 - 0 02 2 -0.58 1 0.111 1 -0.58 2 -1.283 4 -0.87 2 -0.183 3 -0.58 3 -0.582 2 -0.58 0 1002 1 0.11 1 0.110 0 100.00 0 1003 3 -0.58 2 -0.182 2 -0.58 2 -0.581 0 100.00 0 1001 0 - 0 01 0 100.00 0 1000 0 - 0 05 2 0.33 2 0.330 0 100.00 0 1003 0 100.00 0 1007 2 0.67 8 -0.724 2 0.11 0 1000 0 - 0 0

Sheet1

0 0 - 0 01 1 -0.58 0 1002 0 100.00 1 0.110 0 - 2 -1000 0 - 0 00 0 - 0 01 1 -0.58 1 -0.580 0 - 1 -1001 0 - 0 01 0 100.00 1 -0.581 1 -0.58 0 1004 2 0.11 4 -0.582 0 - 0 00 1 -100.00 1 -1000 1 -100.00 1 -1000 0 - 0 01 0 100.00 1 -0.580 1 -100.00 1 -1000 1 -100.00 0 02 0 100.00 1 0.111 1 -0.58 3 -1.681 3 -1.68 4 -1.970 0 - 0 00 0 - 0 01 0 100.00 1 -0.580 0 100.00 0 1000 1 -100.00 1 -1000 1 -100.00 0 02 3 -0.99 0 02 0 100.00 0 1000 0 - 0 00 0 - 0 01 1 -0.58 1 -0.580 0 - 2 -1008 5 -0.11 0 1001 1 -0.58 0 1007 5 -0.25 4 -0.021 1 -0.58 0 1001 1 -0.58 1 -0.581 1 -0.58 0 0

38 23 -0.08 44 -0.730 0 - 1 -1003 0 100.00 0 1001 2 -1.28 1 -0.58

39 23 -0.05 29 -0.292 0 100.00 0 1001 2 -1.28 1 -0.580 0 - 1 -1001 2 -1.28 2 -1.283 3 -0.58 2 -0.183 3 -0.58 3 -0.585 4 -0.36 5 -0.583 3 -0.58 1 0.522 3 -0.99 1 0.11

21 21 -0.58 19 -0.485 1 1.03 5 -0.581 1 -0.58 0 100

Sheet1

1 0 100.00 0 1001 1 -0.58 0 05 2 0.33 6 -0.771 2 -1.28 1 -0.581 1 -0.58 0 1002 1 0.11 1 0.111 2 -1.28 1 -0.58

22 13 -0.06 15 -0.23 4 -0.87 1 0.521 1 -0.58 0 1001 1 -0.58 2 -1.283 9 -1.68 12 -1.972 0 100.00 1 0.113 2 -0.18 1 0.520 0 - 0 00 0 - 1 -1000 0 - 1 -1006 11 -1.19 7 -0.742 1 0.11 1 0.112 1 0.11 1 0.110 0 - 1 -1001 1 -0.58 0 1000 0 - 2 -1004 3 -0.29 3 -0.29

11 8 -0.26 9 -0.388 6 -0.29 6 -0.292 3 -0.99 1 0.110 1 -100.00 1 -1002 0 100.00 0 1003 5 -1.09 5 -1.091 0 - 2 -1.282 2 -0.58 1 0.112 1 0.11 1 0.116 9 -0.99 6 -0.582 4 -1.28 4 -1.281 1 -0.58 1 -0.589 10 -0.69 12 -0.874 3 -0.29 4 -0.584 2 0.11 4 -0.585 6 -0.76 5 -0.581 2 -1.28 1 -0.581 0 - 0 01 0 100.00 0 1003 1 0.52 0 1003 5 -1.09 5 -1.091 1 -0.58 1 -0.589 12 -0.87 10 -0.691 1 -0.58 1 -0.589 4 0.23 4 0.230 0 - 0 0

21 13 -0.10 20 -0.532 1 0.11 2 -0.581 3 -1.68 1 -0.58

29 5 1.18 8 0.714 4 -0.58 5 -0.810 0 - 0 03 4 -0.87 7 -1.43

Sheet1

3 4 -0.87 1 0.527 7 -0.58 8 -0.722 2 -0.58 2 -0.584 6 -0.99 4 -0.580 0 - 0 03 2 -0.18 4 -0.870 0 - 0 04 5 -0.81 2 0.111 0 100.00 1 -0.583 2 -0.18 1 0.521 1 -0.58 1 -0.584 5 -0.81 5 -0.815 5 -0.58 4 -0.36

24 25 -0.62 25 -0.621 1 -0.58 1 -0.583 5 -1.09 6 -1.281 0 100.00 1 -0.580 0 - 0 01 1 -0.58 2 -1.282 1 0.11 1 0.112 2 -0.58 3 -0.992 2 -0.58 3 -0.994 5 -0.81 7 -1.140 0 - 0 01 2 -1.28 4 -1.973 1 0.52 6 -1.281 0 100.00 1 -0.583 2 -0.18 1 0.527 8 -0.72 8 -0.722 6 -1.68 4 -1.284 5 -0.81 2 0.116 7 -0.74 9 -0.990 0 - 0 0

10 13 -0.85 8 -0.360 0 - 0 01 1 -0.58 1 -0.583 1 0.52 1 0.526 11 -1.19 7 -0.742 1 0.11 1 0.110 0 - 0 02 2 -0.58 5 -1.50 0 - 0 03 4 -0.87 5 -1.090 1 -100.00 2 -1000 0 - 0 01 3 -1.68 2 -1.283 3 -0.58 3 -0.584 2 0.11 4 -0.583 2 -0.18 3 -0.582 2 -0.58 2 -0.58

12 11 -0.50 7 -0.045 2 0.33 3 -0.072 0 - 0 01 0 100.00 0 1003 4 -0.87 3 -0.580 1 -100.00 2 -1004 3 -0.29 3 -0.29

Sheet1

0 1 -100.00 1 -10012 7 -0.04 9 -0.377 45 -0.05 39 0.19 13 -0.95 7 -0.331 5 -2.19 3 -1.681 3 -1.68 1 -0.582 2 -0.58 3 -0.991 1 -0.58 1 -0.588 1 1.50 5 -0.111 0 100.00 0 1003 0 100.00 0 1007 5 -0.25 5 -0.250 0 - 0 03 0 100.00 1 0.521 1 -0.58 0 00 0 - 0 02 2 -0.58 1 0.111 2 -1.28 2 -1.284 1 0.80 0 1004 0 100.00 2 0.112 2 -0.58 2 -0.581 0 100.00 0 1001 2 -1.28 1 -0.581 0 100.00 0 1000 2 -100.00 2 -1001 1 -0.58 1 -0.580 0 - 0 02 1 0.11 1 0.110 0 - 0 01 1 -0.58 2 -1.28

27 24 -0.47 23 -0.4237 42 -0.71 32 -0.444 4 -0.58 1 0.81 1 -0.58 1 -0.583 1 0.52 0 1001 1 -0.58 3 -1.681 0 100.00 1 -0.581 1 -0.58 3 -1.681 1 -0.58 3 -1.681 1 -0.58 1 -0.580 0 - 0 00 1 -100.00 0 05 3 -0.07 3 -0.074 3 -0.29 14 -1.840 0 - 0 00 0 - 1 -100

155 37 0.86 39 0.82 2 -0.58 3 -0.995 5 -0.58 5 -0.584 4 -0.58 4 -0.582 1 0.11 0 01 1 -0.58 0 100

22 15 -0.20 44 -1.280 1 -100.00 0 1000 0 - 0 01 1 -0.58 2 -1.280 0 - 0 0

Sheet1

0 3 -100.00 0 02 2 -0.58 4 -1.286 7 -0.74 22 -1.882 4 -1.28 0 1001 1 -0.58 0 00 0 - 2 -1002 1 0.11 1 0.111 2 -1.28 2 -1.282 1 0.11 0 1001 0 100.00 0 1000 0 - 0 0

13 13 -0.58 11 -0.4284 66 -0.34 76 -0.490 0 - 1 -1000 2 -100.00 2 -1000 0 - 0 02 1 0.11 0 1003 4 -0.87 3 -0.581 2 -1.28 2 -1.28

24 0 100.00 7 0.652 3 -0.99 3 -0.991 1 -0.58 0 06 6 -0.58 9 -0.99

13 12 -0.50 8 -0.10 0 - 1 -1000 2 -100.00 0 00 0 - 0 00 0 - 0 05 6 -0.76 3 -0.073 1 0.52 1 0.521 0 100.00 0 1002 5 -1.50 2 -0.580 0 - 0 00 1 -100.00 0 1000 0 - 0 0

24 10 0.29 22 -0.53 3 -0.58 2 -0.180 0 - 0 04 2 0.11 2 0.111 0 100.00 1 -0.58

15 27 -1.17 24 -1.051 0 100.00 0 1001 0 100.00 0 1000 2 -100.00 0 01 0 100.00 0 100

25 10 0.33 12 0.1529 27 -0.51 30 -0.626 9 -0.99 7 -0.740 2 -100.00 1 -1001 2 -1.28 3 -1.681 1 -0.58 0 1001 0 100.00 0 1002 3 -0.99 3 -0.990 1 -100.00 0 00 0 - 0 00 0 100.00 0 1001 1 -0.58 4 -1.97

Sheet1

2 2 -0.58 0 1002 0 100.00 0 1000 0 100.00 1 -1000 0 - 0 02 2 -0.58 1 0.116 6 -0.58 7 -0.741 0 100.00 0 1004 6 -0.99 5 -0.811 1 -0.58 1 -0.580 0 - 1 -1000 1 -100.00 2 -1000 0 - 0 03 2 -0.18 2 -0.183 3 -0.58 5 -1.09

11 7 -0.13 6 0.021 0 - 0 04 1 0.80 1 0.8

12 7 -0.04 7 -0.044 2 0.11 7 -1.140 0 - 0 01 0 100.00 0 1002 1 0.11 2 -0.580 1 -100.00 0 00 1 -100.00 1 -1003 0 100.00 1 0.520 0 - 0 00 1 -100.00 0 04 1 0.80 3 -0.291 1 -0.58 1 -0.581 0 100.00 0 1003 4 -0.87 3 -0.580 0 100.00 0 1002 1 0.11 0 1002 1 0.11 1 0.112 0 100.00 2 -0.580 0 - 1 -1002 2 -0.58 2 -0.582 3 -0.99 3 -0.993 0 100.00 0 1005 3 -0.07 1 1.036 7 -0.74 11 -1.195 4 -0.36 3 -0.07

15 10 -0.18 9 -0.073 4 -0.87 3 -0.580 0 100.00 0 1001 0 - 0 00 0 - 0 03 2 -0.18 2 -0.184 3 -0.29 6 -0.994 3 -0.29 3 -0.29

10 12 -0.77 8 -0.365 4 -0.36 3 -0.071 0 100.00 1 -0.581 1 -0.58 0 100

12 12 -0.58 10 -0.44 0 100.00 2 0.110 0 100.00 0 100

Sheet1

0 1 -100.00 2 -1000 0 - 1 -1000 0 - 0 01 1 -0.58 1 -0.580 0 - 1 -1000 0 100.00 0 1003 1 0.52 1 0.520 0 - 1 -1001 1 -0.58 1 -0.582 3 -0.99 3 -0.990 0 100.00 0 1005 7 -0.92 7 -0.927 11 -1.03 11 -1.048 12 -0.99 7 -0.45

12 12 -0.58 7 -0.043 2 -0.18 2 -0.180 0 - 0 0

17 11 -0.15 9 0.052 0 100.00 0 1000 1 -100.00 0 01 3 -1.68 2 -1.286 8 -0.87 9 -0.99

13 17 -0.85 17 -0.856 6 -0.58 4 -0.182 2 -0.58 2 -0.588 5 -0.11 3 0.41 1 -0.58 1 -0.58

12 12 -0.58 13 -0.661 1 -0.58 2 -1.28

27 15 0.01 17 -0.1216 3 1.09 6 0.42 1 0.11 1 0.111 1 -0.58 0 02 3 -0.99 3 -0.991 1 -0.58 2 -1.285 5 -0.58 2 0.331 1 -0.58 1 -0.586 5 -0.40 5 -0.45 5 -0.58 5 -0.584 3 -0.29 4 -0.580 0 - 1 -1002 1 0.11 0 100

10 9 -0.48 9 -0.481 0 100.00 0 1001 0 100.00 0 1001 1 -0.58 0 1001 1 -0.58 20 -3.587 4 -0.02 2 0.671 2 -1.28 2 -1.286 6 -0.58 4 -0.182 1 0.11 2 -0.580 0 100.00 0 1001 0 100.00 0 1000 0 - 0 0

22 0 100.00 5 0.92 0 100.00 2 -0.580 0 100.00 1 -100

Sheet1

1 0 100.00 0 1004 4 -0.58 2 0.11

15 12 -0.36 8 0.053 2 -0.18 2 -0.181 0 100.00 0 100

81 97 -0.77 90 -0.692 1 0.11 3 -0.990 0 - 1 -1000 0 - 0 00 0 - 0 03 2 -0.18 2 -0.180 3 -100.00 1 -1001 1 -0.58 0 00 0 - 1 -1001 0 100.00 1 -0.58

42 54 -0.84 61 -0.961 1 -0.58 1 -0.581 0 - 0 05 2 0.33 6 -0.774 0 100.00 4 -0.581 0 - 0 00 1 -100.00 0 00 1 -100.00 0 00 0 - 1 -100

26 27 -0.62 18 -0.220 0 - 0 01 1 -0.58 1 -0.580 0 - 1 -100

15 2 1.43 2 1.433 3 -0.58 2 -0.181 1 -0.58 0 1004 2 0.11 2 0.112 3 -0.99 4 -1.282 2 -0.58 3 -0.991 0 100.00 1 -0.580 2 -100.00 0 00 0 - 0 04 3 -0.29 1 0.84 5 -0.81 4 -0.582 1 0.11 4 -1.281 0 100.00 2 -1.281 0 100.00 0 1000 0 - 1 -1001 0 100.00 1 -0.580 0 - 0 05 3 -0.07 1 1.031 0 100.00 1 -0.581 2 -1.28 1 -0.587 3 0.27 0 1001 1 -0.58 0 1000 0 - 0 00 1 -100.00 1 -1000 0 - 0 02 1 0.11 1 0.112 3 -0.99 3 -0.991 0 - 0 03 4 -0.87 6 -1.28

Sheet1

6 3 0.11 2 0.521 0 100.00 0 1001 0 - 0 00 1 -100.00 1 -100

20 35 -1.14 34 -1.122 2 -0.58 3 -0.990 1 -100.00 0 01 0 100.00 0 1001 1 -0.58 1 -0.584 3 -0.29 2 0.110 0 - 0 00 0 - 0 00 0 - 0 03 2 -0.18 2 -0.181 3 -1.68 0 1001 0 100.00 1 -0.581 0 - 0 05 2 0.33 5 -0.582 0 100.00 0 1003 4 -0.87 2 -0.181 1 -0.58 2 -1.281 2 -1.28 2 -1.280 1 -100.00 0 00 0 - 0 00 1 -100.00 0 01 2 -1.28 1 -0.583 1 0.52 1 0.520 1 -100.00 0 1001 2 -1.28 1 -0.582 1 0.11 1 0.110 0 - 0 00 0 100.00 0 1000 1 -100.00 0 00 0 - 0 00 1 -100.00 1 -100

25 26 -0.62 34 -0.893 1 0.52 2 -0.184 1 0.80 2 0.110 0 - 0 03 3 -0.58 1 0.520 0 - 0 00 2 -100.00 0 00 0 - 0 00 0 - 0 01 0 100.00 1 -0.582 0 100.00 0 1000 1 -100.00 0 00 0 - 0 00 1 -100.00 1 -1001 1 -0.58 1 -0.581 0 100.00 1 -0.582 1 0.11 1 0.110 0 - 0 01 0 - 0 00 0 - 0 00 0 - 1 -1000 0 - 0 0

Sheet1

0 0 - 0 00 0 - 0 02 1 0.11 3 -0.99

23 8 0.47 15 -0.161 3 -1.68 2 -1.280 0 - 0 06 12 -1.28 1 1.211 0 - 2 -1.289 6 -0.18 8 -0.471 1 -0.58 0 1001 4 -1.97 1 -0.580 0 - 0 00 0 - 1 -1000 0 - 0 09 9 -0.58 8 -0.470 1 -100.00 2 -1002 2 -0.58 1 0.112 2 -0.58 0 1000 0 - 0 02 2 -0.58 2 -0.583 3 -0.58 2 -0.182 3 -0.99 2 -0.584 4 -0.58 3 -0.291 0 - 1 -0.582 2 -0.58 1 0.113 1 0.52 2 -0.18

37 10 0.73 16 0.264 0 100.00 0 1000 2 -100.00 0 01 1 -0.58 2 -1.280 0 - 0 02 2 -0.58 1 0.111 1 -0.58 1 -0.583 2 -0.18 0 1000 0 - 1 -1001 0 100.00 0 1000 0 - 1 -1002 2 -0.58 2 -0.580 0 - 1 -1001 1 -0.58 0 1001 0 100.00 0 100

17 5 0.64 11 -0.150 1 -100.00 1 -1000 0 - 1 -1000 0 - 0 00 1 -100.00 1 -1000 0 - 0 02 3 -0.99 2 -0.587 6 -0.43 5 -0.250 0 - 0 03 3 -0.58 2 -0.181 1 -0.58 1 -0.580 0 100.00 0 1001 0 - 0 00 1 -100.00 1 -1000 0 - 0 01 1 -0.58 0 100

Sheet1

1 2 -1.28 1 -0.581 0 - 0 04 4 -0.58 2 0.111 4 -1.97 1 -0.580 0 - 0 00 0 - 3 -1002 2 -0.58 1 0.111 1 -0.58 1 -0.580 0 - 0 01 1 -0.58 0 1000 0 - 1 -1001 1 -0.58 0 1000 2 -100.00 2 -1000 0 - 0 02 0 100.00 0 1000 0 - 0 00 0 - 0 0

12 12 -0.58 15 -0.812 2 -0.58 0 1002 1 0.11 0 1001 0 100.00 2 -1.281 0 100.00 0 1001 1 -0.58 2 -1.280 1 -100.00 0 02 0 100.00 0 1000 0 - 1 -1009 12 -0.87 17 -1.220 1 -100.00 4 -1002 5 -1.50 2 -0.580 1 -100.00 4 -1004 1 0.80 5 -0.814 3 -0.29 2 0.110 1 -100.00 3 -1003 1 0.52 1 0.522 1 0.11 1 0.114 4 -0.58 2 0.115 5 -0.58 2 0.334 5 -0.81 5 -0.810 0 100.00 1 -1001 1 -0.58 1 -0.581 1 -0.58 1 -0.581 2 -1.28 2 -1.281 2 -1.28 2 -1.282 2 -0.58 3 -0.990 1 -100.00 0 01 1 -0.58 2 -1.280 0 - 0 02 0 100.00 3 -0.990 1 -100.00 0 01 0 - 0 01 2 -1.28 0 1003 3 -0.58 3 -0.582 1 0.11 1 0.111 0 100.00 0 1002 3 -0.99 3 -0.991 1 -0.58 4 -1.970 1 -100.00 0 0

Sheet1

1 0 100.00 0 1000 0 - 0 02 2 -0.58 0 1001 2 -1.28 3 -1.684 2 0.11 0 1000 4 -100.00 2 -100

28 30 -0.65 31 -0.690 0 - 0 01 0 - 1 -0.581 1 -0.58 1 -0.584 3 -0.29 1 0.82 0 - 0 00 0 - 0 02 1 0.11 1 0.111 0 100.00 0 1001 0 100.00 0 1001 1 -0.58 1 -0.580 1 -100.00 1 -1000 0 - 0 02 2 -0.58 3 -0.990 0 100.00 0 1000 0 - 0 00 0 100.00 0 1001 0 - 1 -0.580 0 100.00 0 1000 0 - 0 00 1 -100.00 0 00 0 - 0 00 1 -100.00 0 01 4 -1.97 2 -1.283 0 - 0 01 0 - 1 -0.581 0 100.00 0 1000 0 100.00 0 1001 0 100.00 0 1001 0 - 0 00 0 - 0 01 1 -0.58 1 -0.583 2 -0.18 1 0.520 0 - 0 03 1 0.52 1 0.521 1 -0.58 1 -0.580 0 - 1 -1000 0 - 1 -1002 0 - 1 0.114 3 -0.29 5 -0.811 0 - 0 00 0 - 0 01 1 -0.58 1 -0.582 1 0.11 1 0.111 0 100.00 0 1000 1 -100.00 0 01 0 - 0 00 0 - 2 -100

11 7 -0.13 7 -0.130 0 - 0 03 2 -0.18 2 -0.18

Sheet1

2 2 -0.58 1 0.111 1 -0.58 0 1004 5 -0.81 4 -0.580 1 -100.00 0 00 0 - 1 -1002 0 100.00 0 1000 0 - 0 0

18 4 0.92 17 -0.530 1 -100.00 0 100

11 10 -0.49 5 0.211 0 100.00 0 1002 1 0.11 1 0.111 0 100.00 0 1001 0 100.00 0 1000 0 - 0 01 1 -0.58 0 1000 0 - 0 01 2 -1.28 1 -0.580 0 - 0 00 0 - 0 03 4 -0.87 2 -0.180 2 -100.00 1 -1000 0 - 1 -1000 0 - 0 01 1 -0.58 1 -0.581 1 -0.58 1 -0.581 0 100.00 0 1001 0 100.00 0 1000 1 -100.00 1 -1000 0 - 1 -1000 0 - 0 00 1 -100.00 0 00 0 - 1 -1001 0 100.00 0 1004 3 -0.29 4 -0.581 0 100.00 0 100

11 11 -0.58 15 -0.890 0 - 0 06 5 -0.40 4 -0.180 1 -100.00 0 00 1 -100.00 1 -1002 4 -1.28 4 -1.280 0 - 1 -1000 0 - 0 00 2 -100.00 0 02 1 0.11 1 0.110 0 - 1 -1002 2 -0.58 1 0.113 1 0.52 1 0.521 0 - 0 00 0 - 0 00 1 -100.00 0 03 2 -0.18 3 -0.580 1 -100.00 0 01 1 -0.58 0 1000 1 -100.00 0 00 0 - 0 0

Sheet1

2 3 -0.99 2 -0.582 1 0.11 1 0.111 0 100.00 0 1000 0 - 0 01 0 - 1 -0.582 2 -0.58 2 -0.585 5 -0.58 4 -0.363 3 -0.58 1 0.521 0 - 0 01 2 -1.28 4 -1.973 3 -0.58 6 -1.286 5 -0.40 3 0.111 2 -1.28 0 1001 1 -0.58 1 -0.580 2 -100.00 0 00 0 - 0 05 4 -0.36 4 -0.362 0 100.00 0 1000 0 - 2 -1003 2 -0.18 2 -0.181 0 100.00 1 -0.580 0 - 0 03 2 -0.18 1 0.521 1 -0.58 1 -0.581 1 -0.58 1 -0.582 1 0.11 0 1001 4 -1.97 2 -1.283 5 -1.09 5 -1.091 0 100.00 0 1001 2 -1.28 1 -0.583 4 -0.87 4 -0.870 1 -100.00 1 -1005 12 -1.46 7 -0.920 0 - 0 01 1 -0.58 1 -0.580 0 - 2 -1001 1 -0.58 0 1001 0 - 0 01 1 -0.58 1 -0.580 0 - 2 -1002 2 -0.58 2 -0.580 0 - 1 -1001 1 -0.58 1 -0.580 1 -100.00 0 00 0 100.00 0 1000 0 - 0 00 1 -100.00 0 01 1 -0.58 1 -0.581 2 -1.28 2 -1.280 2 -100.00 0 01 1 -0.58 1 -0.580 1 -100.00 0 09 8 -0.46 7 -0.331 3 -1.68 0 01 2 -1.28 1 -0.581 0 100.00 0 1000 0 - 0 0

Sheet1

1 1 -0.58 0 1001 0 100.00 0 1000 0 - 1 -1004 3 -0.29 4 -0.580 0 - 0 04 1 0.80 2 0.110 1 -100.00 2 -1000 1 -100.00 1 -1004 2 0.11 3 -0.291 1 -0.58 4 -1.97

11 15 -0.89 17 -1.024 5 -0.81 11 -1.63 4 -0.87 11 -1.880 0 100.00 0 1004 6 -0.99 5 -0.812 4 -1.28 2 -0.582 2 -0.58 1 0.110 0 - 1 -1001 2 -1.28 1 -0.583 1 0.52 1 0.52

24 3 1.50 17 -0.243 2 -0.18 2 -0.182 1 0.11 1 0.111 0 100.00 0 1002 1 0.11 0 1002 1 0.11 3 -0.990 0 - 0 00 1 -100.00 0 00 0 - 0 00 0 - 0 01 0 100.00 0 1000 1 -100.00 1 -1002 1 0.11 1 0.110 0 - 0 00 2 -100.00 1 -1001 0 - 1 -0.581 0 100.00 0 1000 0 - 0 01 0 100.00 0 1000 0 - 0 0

13 12 -0.50 33 -1.521 1 -0.58 0 1000 0 - 0 05 5 -0.58 5 -0.586 8 -0.87 8 -0.872 1 0.11 4 -1.280 0 - 0 00 0 - 2 -1001 4 -1.97 3 -1.680 0 - 0 00 0 - 1 -1000 0 - 1 -1003 1 0.52 1 0.520 0 - 0 00 0 - 0 00 1 -100.00 0 00 0 - 0 0

Sheet1

3 1 0.52 1 0.523 2 -0.18 1 0.522 0 100.00 0 1002 0 100.00 0 1000 1 -100.00 1 -1001 1 -0.58 0 01 0 - 0 00 1 -100.00 1 -1001 0 100.00 1 -0.582 1 0.11 5 -1.55 2 0.33 1 1.030 0 - 0 06 6 -0.58 5 -0.41 2 -1.28 2 -1.281 0 100.00 0 1001 1 -0.58 0 1002 2 -0.58 0 1001 0 - 0 03 2 -0.18 1 0.521 0 100.00 0 1001 0 100.00 1 -0.589 15 -1.09 14 -1.031 4 -1.97 1 -0.58

11 15 -0.89 11 -0.5822 10 0.21 12 0.021 1 -0.58 1 -0.580 0 - 0 00 0 100.00 0 1000 1 -100.00 0 04 2 0.11 2 0.110 0 - 0 02 2 -0.58 0 04 2 0.11 5 -0.814 2 0.11 5 -0.815 6 -0.76 6 -0.770 0 - 0 05 2 0.33 6 -0.771 0 100.00 1 -0.581 0 100.00 0 1000 0 - 1 -1000 0 - 0 03 2 -0.18 4 -0.871 1 -0.58 2 -1.282 2 -0.58 2 -0.583 0 100.00 2 -0.185 4 -0.36 6 -0.772 0 100.00 0 1000 1 -100.00 0 00 1 -100.00 0 00 1 -100.00 1 -1001 3 -1.68 1 -0.584 7 -1.14 20 -2.19

12 7 -0.04 9 -0.31 1 -0.58 1 -0.583 2 -0.18 2 -0.180 1 -100.00 0 00 0 - 0 0

Sheet1

10 3 0.62 5 0.118 8 -0.58 8 -0.581 0 100.00 0 1000 0 - 0 00 1 -100.00 0 02 0 100.00 0 1000 1 -100.00 0 01 1 -0.58 1 -0.580 1 -100.00 0 01 0 100.00 0 1000 0 - 0 01 1 -0.58 0 1001 1 -0.58 0 1000 0 - 1 -1001 3 -1.68 1 -0.581 2 -1.28 1 -0.582 1 0.11 0 1003 5 -1.09 5 -1.090 0 - 0 03 2 -0.18 2 -0.182 1 0.11 1 0.111 1 -0.58 2 -1.282 1 0.11 1 0.111 3 -1.68 13 -3.150 0 - 0 05 2 0.33 3 -0.072 0 100.00 1 0.111 0 - 0 00 0 - 0 00 0 - 3 -1001 0 100.00 0 1001 0 100.00 0 1000 1 -100.00 0 00 0 - 0 0

11 5 0.21 8 -0.261 0 100.00 1 -0.581 1 -0.58 0 1003 5 -1.09 3 -0.581 0 100.00 0 1001 3 -1.68 2 -1.280 0 - 8 -1000 1 -100.00 0 100

11 10 -0.49 6 0.024 5 -0.81 3 -0.290 0 - 0 01 2 -1.28 1 -0.581 0 100.00 0 1003 3 -0.58 4 -0.872 3 -0.99 3 -0.990 1 -100.00 0 1003 2 -0.18 3 -0.584 2 0.11 1 0.81 2 -1.28 1 -0.587 3 0.27 2 0.671 0 100.00 0 1000 0 - 1 -1000 0 - 1 -100

Sheet1

0 0 - 0 01 1 -0.58 0 1001 1 -0.58 0 1001 0 100.00 0 1000 3 -100.00 11 -1001 1 -0.58 1 -0.580 0 - 0 01 1 -0.58 0 00 1 -100.00 0 01 0 100.00 2 -1.28

13 15 -0.73 13 -0.581 1 -0.58 1 -0.581 2 -1.28 1 -0.581 1 -0.58 1 -0.581 3 -1.68 2 -1.284 5 -0.81 3 -0.290 1 -100.00 1 -1001 0 - 0 02 2 -0.58 3 -0.991 2 -1.28 3 -1.682 0 100.00 1 0.114 5 -0.81 7 -1.143 1 0.52 2 -0.181 2 -1.28 1 -0.581 3 -1.68 4 -1.97

10 14 -0.92 12 -0.771 4 -1.97 5 -2.193 4 -0.87 0 1001 1 -0.58 1 -0.581 0 - 0 07 7 -0.58 11 -1.043 2 -0.18 2 -0.18

24 23 -0.54 19 -0.3520 13 -0.15 12 -0.075 4 -0.36 4 -0.361 3 -1.68 0 100

11 3 0.72 1 1.820 1 -100.00 0 01 2 -1.28 1 -0.582 3 -0.99 3 -0.990 0 - 1 -1002 5 -1.50 2 -0.581 1 -0.58 0 1002 1 0.11 1 0.111 2 -1.28 0 1002 4 -1.28 0 1004 3 -0.29 2 0.111 1 -0.58 1 -0.582 1 0.11 2 -0.581 0 - 0 06 6 -0.58 3 0.111 1 -0.58 1 -0.583 2 -0.18 1 0.524 1 0.80 0 1002 1 0.11 1 0.112 1 0.11 0 1003 0 100.00 3 -0.58

Sheet1

2 0 100.00 0 1001 0 - 0 02 1 0.11 2 -0.581 2 -1.28 1 -0.582 1 0.11 2 -0.584 5 -0.81 3 -0.291 1 -0.58 0 1001 0 100.00 0 1007 5 -0.25 5 -0.251 1 -0.58 1 -0.581 0 100.00 2 -1.283 3 -0.58 2 -0.180 0 - 0 00 1 -100.00 0 02 1 0.11 4 -1.281 1 -0.58 1 -0.585 1 1.03 5 -0.580 0 - 1 -1000 2 -100.00 0 01 0 100.00 1 -0.580 0 - 0 01 0 100.00 0 1001 0 100.00 0 1000 1 -100.00 0 01 2 -1.28 1 -0.580 1 -100.00 1 -1000 1 -100.00 0 1000 1 -100.00 0 01 0 100.00 0 1001 1 -0.58 0 00 0 - 0 02 1 0.11 0 1006 6 -0.58 4 -0.184 1 0.80 0 1000 0 - 0 01 1 -0.58 2 -1.280 0 - 0 00 1 -100.00 0 03 4 -0.87 4 -0.871 2 -1.28 1 -0.581 1 -0.58 1 -0.583 2 -0.18 3 -0.588 4 0.11 5 -0.112 1 0.11 1 0.114 2 0.11 2 0.114 3 -0.29 4 -0.580 0 - 0 0

14 13 -0.51 16 -0.721 1 -0.58 1 -0.586 6 -0.58 6 -0.582 2 -0.58 3 -0.993 1 0.52 1 0.520 0 - 1 -1001 1 -0.58 1 -0.581 0 100.00 1 -0.581 1 -0.58 1 -0.582 1 0.11 1 0.11

Sheet1

1 2 -1.28 2 -1.284 2 0.11 1 0.82 2 -0.58 1 0.113 0 100.00 0 1001 1 -0.58 1 -0.580 0 - 0 01 0 100.00 0 1000 0 - 0 02 1 0.11 1 0.111 1 -0.58 1 -0.581 1 -0.58 1 -0.581 0 100.00 0 1001 0 - 0 0

21 9 0.27 30 -0.942 0 100.00 1 0.110 0 - 0 05 3 -0.07 3 -0.071 1 -0.58 0 1004 1 0.80 1 0.83 1 0.52 1 0.520 0 - 0 01 2 -1.28 2 -1.281 1 -0.58 0 1000 0 - 0 01 0 100.00 0 1001 1 -0.58 0 1001 0 100.00 0 1001 1 -0.58 1 -0.580 1 -100.00 0 03 3 -0.58 4 -0.872 2 -0.58 4 -1.28

15 10 -0.18 19 -0.8221 19 -0.48 19 -0.488 1 1.50 2 0.85 2 0.33 2 0.331 1 -0.58 1 -0.580 0 100.00 2 -1001 1 -0.58 1 -0.581 1 -0.58 3 -1.681 2 -1.28 1 -0.58

14 10 -0.25 7 0.111 1 -0.58 1 -0.581 1 -0.58 2 -1.280 1 -100.00 1 -1000 0 - 1 -1003 7 -1.43 3 -0.585 5 -0.58 3 -0.073 2 -0.18 3 -0.580 1 -100.00 0 04 4 -0.58 0 1002 1 0.11 2 -0.580 0 - 0 00 2 -100.00 1 -1004 3 -0.29 4 -0.582 5 -1.50 1 0.111 1 -0.58 2 -1.288 4 0.11 6 -0.29

Sheet1

3 4 -0.87 0 1000 0 - 1 -1001 2 -1.28 1 -0.581 3 -1.68 1 -0.581 2 -1.28 6 -2.371 1 -0.58 1 -0.583 1 0.52 1 0.522 1 0.11 2 -0.584 4 -0.58 3 -0.297 5 -0.25 4 -0.020 1 -100.00 1 -1001 1 -0.58 1 -0.58

20 14 -0.23 9 0.221 2 -1.28 2 -1.28

29 13 0.22 26 -0.470 0 - 0 00 0 100.00 0 1000 1 -100.00 0 1001 1 -0.58 2 -1.282 2 -0.58 2 -0.581 3 -1.68 2 -1.28

117 109 -0.52 88 -0.37 2 0.67 4 -0.021 2 -1.28 0 1001 0 100.00 0 1001 0 100.00 1 -0.580 0 - 0 00 2 -100.00 2 -1000 0 100.00 0 1000 0 - 0 03 0 100.00 0 1001 0 100.00 0 1000 0 - 0 00 0 - 1 -1000 0 - 1 -1000 0 - 0 01 0 - 0 01 2 -1.28 1 -0.582 1 0.11 1 0.115 3 -0.07 3 -0.071 2 -1.28 0 01 1 -0.58 1 -0.584 2 0.11 3 -0.292 1 0.11 2 -0.580 0 - 0 01 1 -0.58 1 -0.580 0 - 0 00 0 - 0 00 1 -100.00 1 -1001 1 -0.58 1 -0.581 1 -0.58 2 -1.282 1 0.11 0 1003 5 -1.09 10 -1.792 2 -0.58 3 -0.990 0 100.00 1 -1000 1 -100.00 1 -1000 0 - 1 -100

Sheet1

4 3 -0.29 1 0.81 1 -0.58 0 1000 1 -100.00 0 00 1 -100.00 0 00 0 - 0 00 0 - 0 01 3 -1.68 1 -0.583 4 -0.87 3 -0.58

22 25 -0.71 25 -0.710 0 - 0 01 1 -0.58 2 -1.280 0 - 0 0

13 6 0.19 5 0.371 0 100.00 0 1002 0 100.00 1 0.110 0 - 0 00 1 -100.00 0 00 1 -100.00 1 -1001 2 -1.28 2 -1.280 0 - 0 01 0 100.00 0 1001 1 -0.58 1 -0.582 0 100.00 0 1000 0 - 0 00 0 - 0 00 0 - 1 -1000 1 -100.00 0 00 2 -100.00 0 01 0 100.00 2 -1.285 0 100.00 1 1.031 0 100.00 1 -0.580 0 - 0 00 1 -100.00 3 -1000 0 - 0 01 2 -1.28 4 -1.970 0 100.00 1 -1001 1 -0.58 0 1000 1 -100.00 1 -1001 0 100.00 0 1000 0 - 0 00 0 - 1 -1000 2 -100.00 0 00 0 - 0 00 1 -100.00 0 02 2 -0.58 2 -0.581 0 100.00 0 1001 0 100.00 0 1000 0 100.00 0 1001 1 -0.58 2 -1.280 0 - 0 01 0 - 2 -1.280 1 -100.00 1 -1001 1 -0.58 0 03 2 -0.18 3 -0.580 1 -100.00 0 02 1 0.11 0 1001 1 -0.58 1 -0.58

Sheet1

1 1 -0.58 1 -0.582 2 -0.58 7 -1.840 0 - 0 00 2 -100.00 2 -1004 5 -0.81 4 -0.580 0 - 0 00 1 -100.00 0 1001 0 100.00 0 1001 0 100.00 0 1007 5 -0.25 1 1.360 1 -100.00 0 00 0 - 0 00 0 - 0 01 1 -0.58 1 -0.580 0 - 0 01 1 -0.58 1 -0.583 5 -1.09 0 1001 0 100.00 1 -0.580 0 - 2 -1001 1 -0.58 3 -1.680 0 - 0 01 1 -0.58 1 -0.581 0 100.00 3 -1.680 1 -100.00 1 -1000 2 -100.00 0 01 1 -0.58 3 -1.680 2 -100.00 0 00 1 -100.00 0 00 0 - 1 -1001 0 - 0 00 0 - 0 00 0 100.00 0 1001 0 100.00 0 100

18 19 -0.64 27 -0.990 0 - 0 02 0 100.00 0 1006 1 1.21 1 1.212 1 0.11 0 1000 1 -100.00 0 00 0 - 0 01 2 -1.28 0 1001 1 -0.58 2 -1.280 1 -100.00 1 -1000 2 -100.00 1 -1003 0 100.00 0 1000 1 -100.00 0 01 6 -2.37 2 -1.280 0 - 0 01 1 -0.58 0 00 0 - 0 00 0 - 0 01 0 100.00 0 1000 3 -100.00 0 1000 0 - 0 01 0 - 0 00 1 -100.00 1 -1000 1 -100.00 1 -100

Sheet1

0 2 -100.00 0 00 0 - 0 05 6 -0.76 2 0.330 0 - 0 03 2 -0.18 1 0.520 0 - 0 00 0 - 0 01 1 -0.58 0 1001 1 -0.58 0 1000 2 -100.00 1 -1001 0 - 0 00 1 -100.00 0 00 1 -100.00 0 1002 3 -0.99 1 0.111 2 -1.28 1 -0.580 1 -100.00 2 -1001 0 100.00 1 -0.582 3 -0.99 2 -0.582 1 0.11 1 0.111 0 - 0 00 0 - 0 00 0 - 0 00 0 - 0 01 1 -0.58 2 -1.283 1 0.52 1 0.526 8 -0.87 7 -0.740 0 - 1 -1001 0 - 1 -0.58

14 12 -0.43 10 -0.250 1 -100.00 0 01 0 100.00 0 1000 1 -100.00 2 -1000 0 100.00 0 1000 1 -100.00 1 -1000 1 -100.00 0 01 0 100.00 0 1001 1 -0.58 1 -0.58

11 15 -0.89 14 -0.820 0 - 1 -1001 2 -1.28 2 -1.281 0 100.00 0 1002 1 0.11 0 1001 1 -0.58 0 01 2 -1.28 2 -1.280 1 -100.00 1 -1002 2 -0.58 2 -0.586 4 -0.18 3 0.112 1 0.11 4 -1.282 0 100.00 1 0.111 1 -0.58 0 100

26 20 -0.32 15 -0.030 2 -100.00 0 00 1 -100.00 0 00 0 100.00 1 -1006 5 -0.40 6 -0.580 0 - 0 01 1 -0.58 1 -0.58

Sheet1

0 0 - 0 03 0 100.00 0 1003 3 -0.58 5 -1.096 2 0.52 0 1000 0 100.00 0 1004 1 0.80 2 0.11

28 14 0.11 10 0.450 1 -100.00 0 01 0 100.00 0 1000 0 - 1 -1001 2 -1.28 1 -0.581 0 100.00 0 1003 1 0.52 1 0.520 0 - 0 01 0 100.00 1 -0.580 2 -100.00 1 -1000 1 -100.00 0 00 2 -100.00 0 00 1 -100.00 1 -1001 0 100.00 0 1001 0 100.00 0 1000 1 -100.00 0 00 0 - 0 00 0 100.00 0 1000 0 - 1 -1001 1 -0.58 0 1000 1 -100.00 0 00 0 100.00 0 1001 4 -1.97 1 -0.580 1 -100.00 0 01 0 100.00 0 1002 0 100.00 0 1001 3 -1.68 1 -0.580 0 - 0 01 1 -0.58 0 01 0 - 1 -0.583 1 0.52 3 -0.589 7 -0.33 7 -0.330 0 - 0 0

10 7 -0.23 6 -0.071 2 -1.28 1 -0.581 1 -0.58 0 1004 6 -0.99 3 -0.291 1 -0.58 1 -0.580 1 -100.00 1 -1001 1 -0.58 0 1001 1 -0.58 1 -0.587 7 -0.58 8 -0.720 0 - 2 -1003 3 -0.58 2 -0.182 0 100.00 1 0.11

26 41 -1.04 32 -0.797 4 -0.02 3 0.264 2 0.11 11 -1.62 2 -0.58 1 0.110 0 100.00 0 1002 0 100.00 0 100

Sheet1

1 1 -0.58 1 -0.581 2 -1.28 1 -0.582 3 -0.99 1 0.110 0 - 1 -1000 0 100.00 0 1001 1 -0.58 1 -0.581 0 100.00 3 -1.680 1 -100.00 1 -1000 0 - 0 02 0 100.00 0 1000 3 -100.00 0 01 0 100.00 0 1001 0 - 0 00 0 - 0 01 0 100.00 0 1000 2 -100.00 0 00 1 -100.00 3 -1002 0 100.00 0 1006 5 -0.40 3 0.11

16 4 0.80 4 0.84 2 0.11 4 -0.58

11 14 -0.82 14 -0.820 1 -100.00 0 00 0 - 2 -1001 0 100.00 0 1000 0 - 1 -1000 1 -100.00 0 01 1 -0.58 1 -0.581 1 -0.58 1 -0.580 0 - 0 02 2 -0.58 3 -0.993 2 -0.18 3 -0.580 0 - 0 04 2 0.11 3 -0.29

10 13 -0.85 11 -0.683 2 -0.18 3 -0.583 1 0.52 2 -0.183 2 -0.18 3 -0.584 2 0.11 2 0.111 0 100.00 0 1003 1 0.52 0 1001 1 -0.58 1 -0.582 2 -0.58 1 0.111 1 -0.58 0 1000 2 -100.00 1 -1000 0 100.00 1 -1000 0 - 1 -1001 1 -0.58 1 -0.581 0 100.00 0 100

70 65 -0.51 59 -0.410 0 - 0 01 1 -0.58 0 01 1 -0.58 1 -0.583 2 -0.18 2 -0.180 0 - 0 0

14 9 -0.14 7 0.110 1 -100.00 1 -100

Sheet1

2 0 100.00 2 -0.581 0 100.00 0 1000 0 - 0 07 4 -0.02 2 0.672 1 0.11 1 0.110 1 -100.00 0 00 0 - 1 -1004 2 0.11 2 0.110 1 -100.00 0 01 1 -0.58 1 -0.580 0 - 1 -1000 0 - 1 -1000 2 -100.00 2 -1000 0 - 0 01 0 100.00 1 -0.584 5 -0.81 3 -0.290 2 -100.00 0 01 0 100.00 0 1001 0 100.00 0 1000 0 - 0 00 0 - 0 00 1 -100.00 3 -1000 0 - 0 00 1 -100.00 1 -1003 3 -0.58 5 -1.092 0 100.00 0 1000 0 - 1 -1001 0 100.00 0 100

15 13 -0.44 11 -0.271 0 100.00 0 1001 1 -0.58 0 03 4 -0.87 0 1001 0 100.00 0 1001 1 -0.58 0 1001 0 - 0 0

11 12 -0.67 9 -0.380 0 100.00 0 1001 1 -0.58 0 1000 0 100.00 1 -1001 1 -0.58 1 -0.583 0 100.00 1 0.520 1 -100.00 1 -1000 0 - 1 -100

21 17 -0.37 25 -0.760 0 - 0 00 1 -100.00 0 00 1 -100.00 0 02 1 0.11 1 0.110 1 -100.00 0 00 0 - 0 00 0 - 0 00 0 - 0 05 6 -0.76 12 -1.460 1 -100.00 1 -1000 0 - 1 -1001 2 -1.28 3 -1.681 1 -0.58 2 -1.28

Sheet1

51 70 -0.90 72 -0.930 0 100.00 0 1001 0 100.00 0 1001 1 -0.58 0 1000 0 - 0 04 3 -0.29 3 -0.291 2 -1.28 1 -0.583 4 -0.87 2 -0.182 4 -1.28 6 -1.684 3 -0.29 4 -0.580 0 - 0 01 2 -1.28 2 -1.28

20 10 0.11 11 0.020 0 - 1 -1000 0 - 0 00 1 -100.00 0 01 0 100.00 0 1003 1 0.52 1 0.521 0 100.00 2 -1.282 2 -0.58 1 0.112 0 100.00 1 0.110 0 - 0 00 0 - 1 -100

18 13 -0.26 9 0.111 1 -0.58 2 -1.281 1 -0.58 0 1001 2 -1.28 2 -1.281 0 - 0 00 1 -100.00 0 00 0 100.00 0 1001 1 -0.58 0 1000 1 -100.00 1 -1006 4 -0.18 2 0.522 1 0.11 2 -0.580 0 - 0 03 2 -0.18 3 -0.581 0 - 0 00 2 -100.00 1 -1002 1 0.11 0 1001 2 -1.28 1 -0.581 1 -0.58 1 -0.583 2 -0.18 3 -0.582 1 0.11 0 1001 1 -0.58 1 -0.580 1 -100.00 0 01 0 - 0 01 1 -0.58 0 1000 1 -100.00 0 02 2 -0.58 3 -0.990 0 100.00 0 1001 2 -1.28 1 -0.580 1 -100.00 0 07 6 -0.43 4 -0.024 1 0.80 1 0.80 1 -100.00 1 -1000 0 - 0 00 1 -100.00 4 -100

Sheet1

3 2 -0.18 0 1001 0 100.00 0 1000 0 - 0 01 0 100.00 1 -0.581 1 -0.58 0 1000 0 - 0 01 1 -0.58 1 -0.581 5 -2.19 0 1001 2 -1.28 1 -0.580 1 -100.00 1 -1001 1 -0.58 1 -0.580 0 - 0 00 0 - 0 01 3 -1.68 2 -1.282 2 -0.58 3 -0.991 1 -0.58 1 -0.582 1 0.11 3 -0.991 0 100.00 0 1009 11 -0.78 22 -1.481 0 100.00 0 1001 0 100.00 0 1000 1 -100.00 0 01 0 - 2 -1.280 0 - 0 00 0 - 0 00 0 - 0 01 1 -0.58 2 -1.280 1 -100.00 0 09 5 0.01 6 -0.182 0 100.00 0 100

15 8 0.05 7 0.184 7 -1.14 4 -0.580 1 -100.00 0 00 0 - 0 01 1 -0.58 2 -1.280 0 - 0 00 0 - 0 00 0 - 0 01 0 100.00 0 1000 0 - 1 -1003 4 -0.87 2 -0.18

13 11 -0.42 17 -0.850 0 - 0 02 1 0.11 2 -0.580 0 - 0 00 0 - 0 01 0 - 0 07 6 -0.43 8 -0.721 1 -0.58 1 -0.582 1 0.11 2 -0.581 1 -0.58 1 -0.580 2 -100.00 2 -1000 1 -100.00 1 -1000 0 100.00 1 -1000 1 -100.00 0 01 0 100.00 0 100

15 11 -0.27 9 -0.07

Sheet1

2 4 -1.28 4 -1.280 0 100.00 0 1003 3 -0.58 6 -1.281 0 - 0 00 0 - 0 05 6 -0.76 7 -0.920 2 -100.00 1 -100

11 9 -0.38 11 -0.582 1 0.11 1 0.111 5 -2.19 1 -0.581 1 -0.58 1 -0.581 0 100.00 1 -0.582 0 100.00 1 0.117 6 -0.43 10 -0.94

58 0 100.00 12 13 2 -0.18 2 -0.182 0 100.00 0 1000 1 -100.00 0 02 3 -0.99 2 -0.580 0 - 1 -1001 1 -0.58 2 -1.283 1 0.52 0 1003 1 0.52 0 1003 2 -0.18 1 0.520 0 - 0 00 1 -100.00 0 02 1 0.11 0 1001 1 -0.58 1 -0.580 0 - 0 03 0 100.00 2 -0.180 1 -100.00 0 04 2 0.11 1 0.80 0 - 1 -1002 4 -1.28 4 -1.281 0 100.00 0 1002 1 0.11 0 100

67 75 -0.70 81 -0.780 0 - 0 01 1 -0.58 1 -0.580 0 - 0 03 3 -0.58 2 -0.181 1 -0.58 1 -0.58

16 10 -0.11 8 0.110 1 -100.00 0 01 1 -0.58 0 1000 1 -100.00 2 -1000 1 -100.00 0 01 2 -1.28 0 1001 1 -0.58 1 -0.580 0 - 0 02 3 -0.99 1 0.111 3 -1.68 1 -0.581 1 -0.58 0 1000 0 - 0 00 0 - 0 04 1 0.80 3 -0.290 0 - 0 0

Sheet1

0 2 -100.00 1 -1001 1 -0.58 2 -1.280 1 -100.00 0 05 1 1.03 0 1000 1 -100.00 0 02 0 100.00 2 -0.586 6 -0.58 5 -0.41 0 100.00 0 1003 6 -1.28 5 -1.090 1 -100.00 0 01 2 -1.28 1 -0.588 2 0.80 3 0.45 2 0.33 4 -0.361 0 100.00 1 -0.581 2 -1.28 1 -0.582 3 -0.99 1 0.115 4 -0.36 5 -0.583 4 -0.87 3 -0.580 0 100.00 1 -1002 1 0.11 2 -0.580 0 - 0 02 1 0.11 1 0.110 0 100.00 0 1001 1 -0.58 0 1000 0 - 0 01 1 -0.58 1 -0.580 0 - 0 02 0 100.00 1 0.110 0 - 0 01 2 -1.28 1 -0.581 0 100.00 1 -0.582 3 -0.99 1 0.110 0 - 0 02 1 0.11 1 0.112 1 0.11 1 0.111 0 100.00 0 1001 2 -1.28 1 -0.580 1 -100.00 5 -1001 1 -0.58 0 1004 1 0.80 3 -0.295 1 1.03 0 1001 1 -0.58 1 -0.581 0 100.00 1 -0.581 0 - 1 -0.581 0 - 2 -1.281 1 -0.58 1 -0.581 1 -0.58 2 -1.281 0 100.00 1 -0.581 1 -0.58 0 1001 1 -0.58 0 1001 1 -0.58 0 1002 2 -0.58 3 -0.990 2 -100.00 1 -1002 2 -0.58 1 0.112 3 -0.99 2 -0.585 4 -0.36 4 -0.360 0 - 1 -100

Sheet1

0 2 -100.00 0 00 0 - 0 07 4 -0.02 3 0.263 1 0.52 2 -0.181 1 -0.58 2 -1.280 1 -100.00 0 01 0 - 1 -0.580 0 - 0 00 0 - 1 -1002 5 -1.50 0 1005 2 0.33 2 0.33

10 13 -0.85 11 -0.681 1 -0.58 1 -0.580 1 -100.00 1 -1000 0 - 0 0

51 35 -0.21 32 -0.120 0 - 1 -1001 1 -0.58 1 -0.582 3 -0.99 1 0.111 1 -0.58 1 -0.582 2 -0.58 5 -1.51 0 - 0 00 0 - 0 01 0 100.00 0 1001 0 100.00 1 -0.586 6 -0.58 9 -0.992 1 0.11 1 0.111 1 -0.58 0 1002 3 -0.99 1 0.112 1 0.11 0 1001 0 100.00 1 -0.582 2 -0.58 0 1003 3 -0.58 2 -0.182 5 -1.50 2 -0.581 0 100.00 0 1004 2 0.11 2 0.112 1 0.11 0 1002 2 -0.58 3 -0.991 2 -1.28 1 -0.584 3 -0.29 2 0.110 0 - 1 -1000 1 -100.00 0 01 0 100.00 1 -0.583 3 -0.58 3 -0.581 0 - 0 04 1 0.80 1 0.81 1 -0.58 1 -0.580 0 - 1 -1001 0 100.00 0 1000 0 - 0 03 2 -0.18 2 -0.182 2 -0.58 1 0.111 1 -0.58 1 -0.582 1 0.11 1 0.111 1 -0.58 1 -0.580 1 -100.00 0 01 2 -1.28 0 100

Sheet1

0 0 - 1 -1001 1 -0.58 2 -1.282 2 -0.58 2 -0.581 2 -1.28 0 1005 1 1.03 0 1000 0 - 0 03 4 -0.87 4 -0.872 2 -0.58 0 1002 0 100.00 1 0.111 1 -0.58 1 -0.581 1 -0.58 1 -0.583 3 -0.58 3 -0.583 2 -0.18 1 0.524 3 -0.29 1 0.82 2 -0.58 2 -0.583 3 -0.58 3 -0.580 0 - 0 04 3 -0.29 5 -0.812 2 -0.58 3 -0.991 1 -0.58 1 -0.585 5 -0.58 7 -0.920 1 -100.00 0 01 1 -0.58 1 -0.582 1 0.11 0 100

13 11 -0.42 12 -0.50 0 - 0 01 1 -0.58 1 -0.580 0 100.00 0 1001 0 100.00 1 -0.584 2 0.11 3 -0.294 4 -0.58 2 0.110 1 -100.00 1 -1000 0 - 0 01 0 100.00 0 1001 0 100.00 0 1000 0 - 1 -1002 1 0.11 2 -0.580 0 - 1 -1002 0 100.00 2 -0.580 1 -100.00 0 01 2 -1.28 1 -0.580 0 100.00 0 1000 0 - 1 -1001 2 -1.28 1 -0.581 2 -1.28 0 1002 0 100.00 0 100

30 6 1.03 11 0.422 1 0.11 1 0.110 1 -100.00 0 02 1 0.11 1 0.111 1 -0.58 1 -0.584 9 -1.39 1 0.80 0 - 0 03 1 0.52 1 0.521 0 100.00 0 1001 0 - 1 -0.580 0 - 0 0

Sheet1

0 0 100.00 0 1000 3 -100.00 3 -1000 0 - 1 -1001 0 100.00 1 -0.580 0 - 0 0

13 9 -0.21 9 -0.210 0 - 0 00 0 100.00 0 1000 2 -100.00 2 -1000 0 - 0 00 0 - 0 01 2 -1.28 1 -0.582 2 -0.58 2 -0.580 1 -100.00 0 00 1 -100.00 0 00 1 -100.00 0 01 1 -0.58 1 -0.583 1 0.52 0 1000 0 - 0 00 0 - 1 -1003 4 -0.87 1 0.521 2 -1.28 0 1000 1 -100.00 0 00 1 -100.00 1 -1009 9 -0.58 12 -0.870 1 -100.00 1 -100

35 16 0.20 22 -0.121 0 100.00 6 -2.371 1 -0.58 1 -0.581 1 -0.58 1 -0.580 1 -100.00 0 01 1 -0.58 3 -1.681 1 -0.58 0 1002 2 -0.58 0 1000 1 -100.00 1 -1000 0 100.00 1 -1003 1 0.52 1 0.520 0 - 0 01 0 100.00 1 -0.580 0 - 0 03 1 0.52 2 -0.185 9 -1.17 5 -0.581 0 100.00 0 1000 0 - 1 -1001 1 -0.58 0 01 1 -0.58 1 -0.584 4 -0.58 5 -0.811 0 100.00 0 1000 0 - 0 02 2 -0.58 2 -0.580 0 - 0 00 1 -100.00 2 -1001 2 -1.28 1 -0.580 0 - 0 01 0 100.00 0 1001 1 -0.58 0 1000 0 - 1 -100

Sheet1

0 1 -100.00 0 03 3 -0.58 5 -1.090 0 - 0 00 1 -100.00 0 0

36 32 -0.47 43 -0.761 1 -0.58 0 1000 2 -100.00 2 -1002 1 0.11 2 -0.584 2 0.11 3 -0.291 3 -1.68 2 -1.281 2 -1.28 1 -0.586 2 0.52 5 -0.46 5 -0.40 6 -0.585 4 -0.36 4 -0.362 2 -0.58 1 0.113 3 -0.58 3 -0.581 1 -0.58 2 -1.284 5 -0.81 2 0.11

15 11 -0.27 7 0.185 4 -0.36 3 -0.077 11 -1.03 8 -0.720 0 - 1 -1002 1 0.11 2 -0.581 0 - 0 02 1 0.11 1 0.111 3 -1.68 1 -0.58

28 21 -0.30 39 -0.920 0 - 0 00 1 -100.00 1 -1001 2 -1.28 3 -1.686 1 1.21 4 -0.181 1 -0.58 1 -0.586 2 0.52 3 0.112 2 -0.58 2 -0.580 0 - 0 01 0 - 1 -0.581 1 -0.58 1 -0.581 0 100.00 1 -0.580 0 - 0 0

11 4 0.43 4 0.430 0 - 0 02 2 -0.58 1 0.111 1 -0.58 1 -0.581 1 -0.58 0 1001 1 -0.58 0 100

18 8 0.23 10 0.010 0 - 0 03 1 0.52 0 1001 1 -0.58 0 1000 0 - 0 00 0 100.00 0 1000 0 - 1 -1000 0 - 1 -1002 0 100.00 0 1001 4 -1.97 1 -0.583 4 -0.87 4 -0.870 0 - 1 -100

Sheet1

1 0 100.00 0 1001 0 100.00 1 -0.581 0 100.00 0 1000 0 100.00 0 1000 0 - 0 01 1 -0.58 1 -0.581 0 100.00 1 -0.583 4 -0.87 3 -0.587 1 1.36 2 0.673 1 0.52 2 -0.181 1 -0.58 1 -0.580 1 -100.00 0 1000 0 - 0 00 0 - 0 05 3 -0.07 8 -1.051 0 100.00 0 1000 0 - 0 01 0 - 0 08 5 -0.11 8 -0.582 1 0.11 0 1000 0 - 0 01 0 100.00 1 -0.585 5 -0.58 3 -0.070 0 - 0 02 3 -0.99 2 -0.581 0 100.00 3 -1.682 0 100.00 0 1007 9 -0.83 4 -0.025 1 1.03 0 1002 2 -0.58 1 0.110 1 -100.00 1 -1002 1 0.11 2 -0.580 0 - 0 0

13 8 -0.10 5 0.371 1 -0.58 0 1001 1 -0.58 0 1001 0 - 0 03 7 -1.43 6 -1.280 1 -100.00 1 -1003 1 0.52 1 0.520 0 - 0 00 0 - 0 01 0 100.00 0 1001 2 -1.28 1 -0.584 4 -0.58 4 -0.581 0 - 0 01 0 100.00 2 -1.282 3 -0.99 1 0.111 2 -1.28 1 -0.582 2 -0.58 2 -0.580 0 100.00 0 1001 0 100.00 0 1002 1 0.11 1 0.11

18 16 -0.47 14 -0.330 1 -100.00 2 -1001 2 -1.28 3 -1.680 0 - 0 0

Sheet1

0 0 100.00 0 1000 0 - 0 01 1 -0.58 1 -0.580 0 - 1 -1000 0 100.00 0 1000 0 - 0 00 0 - 1 -1002 1 0.11 0 1009 2 0.92 7 -0.332 1 0.11 1 0.112 1 0.11 2 -0.581 0 100.00 0 1002 1 0.11 1 0.115 11 -1.37 5 -0.580 1 -100.00 0 00 1 -100.00 0 01 0 100.00 0 1000 0 - 0 02 0 100.00 3 -0.990 1 -100.00 0 00 0 - 1 -1000 1 -100.00 2 -1001 2 -1.28 0 00 4 -100.00 1 -1001 1 -0.58 1 -0.588 9 -0.70 8 -0.581 1 -0.58 1 -0.581 0 100.00 2 -1.281 2 -1.28 2 -1.280 0 - 1 -1000 0 - 0 00 0 - 0 01 0 100.00 0 1002 0 100.00 0 1002 0 100.00 0 1000 0 - 0 02 1 0.11 0 1001 2 -1.28 1 -0.581 1 -0.58 1 -0.580 1 -100.00 0 01 0 100.00 0 1001 1 -0.58 2 -1.283 1 0.52 1 0.520 1 -100.00 0 0

16 11 -0.21 18 -0.70 0 - 1 -1002 2 -0.58 0 01 0 100.00 0 1000 1 -100.00 0 1003 3 -0.58 10 -1.79

17 24 -0.93 23 -0.890 1 -100.00 1 -1000 0 - 0 0

10 0 100.00 29 -1.651 1 -0.58 1 -0.581 0 100.00 0 1005 5 -0.58 4 -0.36

Sheet1

1 1 -0.58 0 1001 0 100.00 0 1001 1 -0.58 0 1000 0 - 0 01 3 -1.68 2 -1.280 0 - 0 01 0 100.00 0 1002 1 0.11 2 -0.581 0 100.00 0 1002 1 0.11 1 0.111 0 100.00 0 1001 0 100.00 0 1000 0 100.00 0 1001 0 100.00 0 1001 0 100.00 1 -0.580 1 -100.00 2 -1002 3 -0.99 0 1005 6 -0.76 8 -1.051 1 -0.58 1 -0.582 3 -0.99 1 0.111 1 -0.58 2 -1.281 0 100.00 0 1000 0 - 0 02 0 100.00 0 1000 0 - 3 -1000 0 - 0 01 0 100.00 1 -0.581 1 -0.58 1 -0.580 0 - 0 00 0 - 0 00 0 100.00 1 -1000 0 - 1 -1000 0 - 0 01 1 -0.58 1 -0.581 0 100.00 0 1001 1 -0.58 0 1001 1 -0.58 1 -0.584 4 -0.58 1 0.80 1 -100.00 0 04 1 0.80 1 0.80 0 - 0 00 0 - 0 00 0 - 0 01 2 -1.28 1 -0.581 3 -1.68 2 -1.281 0 100.00 0 1000 1 -100.00 0 05 4 -0.36 2 0.330 1 -100.00 1 -1006 12 -1.28 11 -1.191 3 -1.68 5 -2.194 3 -0.29 3 -0.290 0 - 1 -1000 0 - 0 03 3 -0.58 2 -0.183 2 -0.18 2 -0.181 2 -1.28 0 100

Sheet1

0 1 -100.00 0 04 1 0.80 1 0.80 1 -100.00 0 02 5 -1.50 5 -1.51 0 - 0 00 0 100.00 0 1000 0 - 1 -1000 0 - 0 00 1 -100.00 0 07 2 0.67 2 0.670 0 - 0 03 3 -0.58 3 -0.580 0 - 1 -1000 0 - 1 -1001 1 -0.58 0 0

10 10 -0.58 9 -0.480 0 - 1 -1001 0 - 0 01 0 100.00 0 1001 1 -0.58 0 100

52 5 1.76 12 0.891 1 -0.58 1 -0.580 0 - 0 00 0 - 1 -1000 1 -100.00 1 -1001 0 100.00 0 100

12 9 -0.29 10 -0.437 51 -0.91 36 -0.563 2 -0.18 2 -0.180 0 - 0 02 1 0.11 0 1002 2 -0.58 3 -0.993 2 -0.18 1 0.521 0 100.00 0 1001 2 -1.28 1 -0.581 1 -0.58 2 -1.280 1 -100.00 0 01 0 100.00 0 1002 5 -1.50 1 0.111 2 -1.28 1 -0.580 0 - 0 00 0 - 0 01 1 -0.58 3 -1.680 0 100.00 0 1003 2 -0.18 3 -0.582 2 -0.58 1 0.111 1 -0.58 2 -1.280 0 - 0 04 3 -0.29 5 -0.810 1 -100.00 0 02 1 0.11 1 0.111 0 100.00 1 -0.589 8 -0.46 9 -0.58

24 26 -0.66 22 -0.50 0 - 0 00 1 -100.00 0 05 5 -0.58 2 0.33

Sheet1

0 0 - 0 00 0 100.00 0 1000 0 100.00 1 -1000 1 -100.00 0 00 0 100.00 0 1000 0 - 1 -1001 2 -1.28 3 -1.681 0 100.00 1 -0.580 0 - 0 06 3 0.11 6 -0.581 0 100.00 2 -1.281 1 -0.58 0 00 0 - 1 -1001 2 -1.28 0 1007 4 -0.02 4 -0.022 2 -0.58 1 0.110 1 -100.00 0 1001 1 -0.58 0 1000 0 - 0 03 1 0.52 0 1001 3 -1.68 1 -0.583 0 100.00 2 -0.182 1 0.11 2 -0.581 0 100.00 1 -0.581 1 -0.58 0 1001 1 -0.58 1 -0.582 2 -0.58 5 -1.50 1 -100.00 0 1000 2 -100.00 1 -1004 7 -1.14 3 -0.291 0 100.00 4 -1.970 1 -100.00 5 -1000 1 -100.00 3 -1001 3 -1.68 2 -1.281 0 100.00 0 100

11 0 100.00 15 -0.890 0 - 0 00 0 - 0 00 1 -100.00 0 01 0 100.00 0 1000 0 - 0 00 0 - 1 -1001 2 -1.28 3 -1.682 2 -0.58 2 -0.580 1 -100.00 1 -1001 2 -1.28 2 -1.281 4 -1.97 2 -1.280 0 - 0 02 1 0.11 1 0.114 2 0.11 2 0.112 2 -0.58 2 -0.580 0 - 0 0

12 5 0.29 3 0.80 0 - 0 04 1 0.80 3 -0.291 0 100.00 2 -1.280 0 - 0 0

Sheet1

0 0 - 0 00 0 - 0 00 1 -100.00 0 06 4 -0.18 5 -0.41 0 100.00 0 1001 0 100.00 1 -0.581 1 -0.58 0 1001 2 -1.28 1 -0.580 1 -100.00 1 -1005 4 -0.36 6 -0.770 0 - 1 -1002 2 -0.58 2 -0.581 0 100.00 0 1001 0 100.00 0 1000 1 -100.00 0 1000 0 - 0 00 0 - 0 00 1 -100.00 0 01 1 -0.58 2 -1.280 0 - 2 -1001 1 -0.58 0 1000 0 - 1 -1001 1 -0.58 1 -0.586 3 0.11 5 -0.4

22 6 0.72 6 0.721 1 -0.58 1 -0.580 1 -100.00 1 -1001 0 100.00 0 1003 2 -0.18 4 -0.87

20 10 0.11 24 -0.771 0 100.00 0 1001 1 -0.58 1 -0.581 1 -0.58 1 -0.580 0 - 0 01 1 -0.58 1 -0.580 0 100.00 0 1000 1 -100.00 0 00 2 -100.00 0 00 3 -100.00 1 -1000 2 -100.00 1 -1000 0 - 0 01 0 - 0 02 1 0.11 0 1006 7 -0.74 7 -0.742 2 -0.58 2 -0.582 2 -0.58 2 -0.580 0 - 0 02 1 0.11 1 0.11

27 38 -0.93 39 -0.950 0 - 1 -1000 1 -100.00 2 -1001 4 -1.97 3 -1.682 1 0.11 3 -0.991 2 -1.28 2 -1.280 1 -100.00 0 1000 0 - 0 00 0 - 0 0

Sheet1

1 1 -0.58 1 -0.582 1 0.11 0 1000 1 -100.00 1 -1001 0 100.00 0 1003 4 -0.87 4 -0.872 1 0.11 1 0.110 1 -100.00 0 03 1 0.52 2 -0.181 4 -1.97 1 -0.580 0 - 0 00 1 -100.00 0 00 1 -100.00 1 -100

55 2 2.74 7 1.481 1 -0.58 1 -0.58

10 12 -0.77 10 -0.581 0 - 0 00 1 -100.00 1 -1002 3 -0.99 1 0.112 2 -0.58 2 -0.580 0 - 1 -1005 3 -0.07 8 -1.050 0 - 0 00 0 - 1 -1000 0 - 0 04 2 0.11 3 -0.290 0 - 0 01 0 100.00 1 -0.581 0 100.00 0 1001 1 -0.58 1 -0.582 2 -0.58 3 -0.990 0 100.00 0 1002 1 0.11 5 -1.52 2 -0.58 2 -0.584 1 0.80 3 -0.291 0 100.00 0 1005 7 -0.92 5 -0.58

69 79 -0.72 60 -0.450 1 -100.00 0 00 2 -100.00 1 -1001 0 - 0 01 0 100.00 0 1001 1 -0.58 1 -0.581 0 100.00 0 1001 1 -0.58 2 -1.28

13 16 -0.79 12 -0.53 1 0.52 1 0.521 1 -0.58 2 -1.285 9 -1.17 10 -1.282 0 100.00 0 1002 5 -1.50 4 -1.280 0 - 0 00 0 - 0 00 0 - 0 00 2 -100.00 0 00 0 - 1 -1001 1 -0.58 3 -1.681 0 100.00 0 100

Sheet1

0 0 - 3 -1002 1 0.11 0 100

21 17 -0.37 12 -0.021 1 -0.58 0 04 5 -0.81 3 -0.292 0 100.00 2 -0.583 2 -0.18 1 0.523 4 -0.87 3 -0.580 1 -100.00 0 03 0 100.00 2 -0.185 2 0.33 5 -0.582 3 -0.99 3 -0.991 1 -0.58 1 -0.582 0 100.00 0 1000 0 - 1 -100

22 24 -0.67 23 -0.631 0 100.00 0 1000 0 - 1 -1000 0 - 0 00 1 -100.00 0 1001 0 100.00 2 -1.282 0 100.00 0 1000 0 - 0 04 7 -1.14 5 -0.810 0 - 0 01 0 100.00 0 1002 0 100.00 2 -0.58

14 10 -0.25 8 -0.0210 8 -0.36 15 -0.990 0 - 0 09 8 -0.46 6 -0.181 1 -0.58 1 -0.581 3 -1.68 3 -1.680 0 - 0 00 1 -100.00 0 00 1 -100.00 1 -1001 0 100.00 0 1000 0 100.00 0 1000 1 -100.00 1 -1001 0 100.00 0 1000 0 - 1 -1006 6 -0.58 7 -0.740 1 -100.00 0 01 0 100.00 0 1007 1 1.36 1 1.363 2 -0.18 2 -0.183 3 -0.58 1 0.521 2 -1.28 5 -2.192 0 100.00 0 1003 2 -0.18 3 -0.580 1 -100.00 0 01 2 -1.28 1 -0.581 2 -1.28 1 -0.580 0 - 1 -1000 1 -100.00 0 00 1 -100.00 1 -1003 2 -0.18 4 -0.87

Sheet1

4 2 0.11 3 -0.290 0 - 0 01 0 100.00 0 1006 5 -0.40 6 -0.580 3 -100.00 0 00 0 - 1 -1003 0 100.00 0 1000 0 - 0 01 1 -0.58 1 -0.582 2 -0.58 2 -0.58

41 40 -0.56 56 -0.91 2 -1.28 1 -0.580 1 -100.00 2 -1002 3 -0.99 0 1002 3 -0.99 1 0.110 1 -100.00 0 0

33 25 -0.31 12 0.430 0 - 0 00 0 - 0 00 0 - 0 01 1 -0.58 1 -0.581 0 100.00 0 1002 3 -0.99 3 -0.992 0 100.00 1 0.113 2 -0.18 1 0.520 0 - 0 00 0 100.00 0 1000 1 -100.00 0 00 1 -100.00 0 01 0 100.00 0 1004 4 -0.58 2 0.111 0 100.00 1 -0.580 0 - 0 00 0 - 0 05 0 100.00 4 -0.360 0 - 1 -1002 1 0.11 2 -0.585 2 0.33 6 -0.771 1 -0.58 3 -1.682 0 100.00 0 1002 2 -0.58 1 0.116 0 100.00 1 1.210 1 -100.00 1 -1000 0 - 0 01 0 100.00 0 1001 2 -1.28 1 -0.580 2 -100.00 1 -1000 1 -100.00 1 -1004 10 -1.50 6 -0.994 8 -1.28 5 -0.812 1 0.11 1 0.112 3 -0.99 4 -1.280 0 - 1 -1002 2 -0.58 1 0.110 0 - 0 01 0 100.00 1 -0.583 0 100.00 1 0.52

Sheet1

1 0 100.00 1 -0.581 2 -1.28 1 -0.582 2 -0.58 2 -0.581 0 100.00 0 1002 1 0.11 1 0.110 0 - 0 0

10 10 -0.58 8 -0.361 1 -0.58 0 1001 2 -1.28 1 -0.585 8 -1.05 2 0.335 5 -0.58 3 -0.070 0 - 0 01 3 -1.68 2 -1.282 0 100.00 1 0.116 8 -0.87 6 -0.580 0 - 1 -1004 4 -0.58 1 0.82 2 -0.58 0 1000 0 - 0 00 1 -100.00 0 01 0 100.00 0 1003 4 -0.87 3 -0.581 0 100.00 0 1000 0 - 0 00 0 - 1 -1001 0 100.00 0 1000 1 -100.00 0 01 0 100.00 0 1002 0 100.00 1 0.110 0 - 0 01 0 100.00 0 1000 1 -100.00 0 00 2 -100.00 0 00 1 -100.00 1 -1004 1 0.80 2 0.112 1 0.11 1 0.110 0 - 0 03 4 -0.87 3 -0.580 0 - 0 09 11 -0.78 17 -1.228 7 -0.45 3 0.41 0 100.00 0 1000 2 -100.00 1 -1002 3 -0.99 4 -1.280 0 - 0 05 3 -0.07 3 -0.073 3 -0.58 2 -0.180 1 -100.00 1 -1000 1 -100.00 0 00 1 -100.00 9 -1001 1 -0.58 1 -0.582 2 -0.58 1 0.110 0 - 0 01 1 -0.58 2 -1.280 1 -100.00 1 -1002 3 -0.99 4 -1.287 7 -0.58 6 -0.43

Sheet1

1 2 -1.28 1 -0.580 0 - 0 00 1 -100.00 0 02 2 -0.58 2 -0.580 0 100.00 3 -1005 9 -1.17 3 -0.071 1 -0.58 1 -0.582 1 0.11 0 100

10 10 -0.58 14 -0.920 1 -100.00 0 1001 1 -0.58 2 -1.281 2 -1.28 2 -1.280 0 - 0 01 2 -1.28 3 -1.681 0 100.00 0 1000 2 -100.00 1 -1000 1 -100.00 0 04 4 -0.58 6 -0.990 0 - 1 -100

21 18 -0.43 13 -0.13 0 100.00 0 1004 10 -1.50 7 -1.14

18 27 -0.99 16 -0.473 2 -0.18 0 1002 1 0.11 2 -0.58

12 6 0.11 6 0.110 1 -100.00 0 1002 0 100.00 0 1004 4 -0.58 2 0.111 0 - 0 00 0 100.00 0 1002 0 - 0 00 0 - 1 -1000 0 - 2 -1000 0 - 0 0

20 19 -0.53 7 0.472 3 -0.99 0 1001 2 -1.28 1 -0.584 4 -0.58 1 0.87 5 -0.25 7 -0.580 1 -100.00 2 -1000 0 - 0 03 0 100.00 1 0.520 0 - 0 01 0 100.00 1 -0.580 0 - 1 -1001 1 -0.58 2 -1.281 0 100.00 0 1001 0 100.00 0 1000 0 - 0 00 0 - 0 01 1 -0.58 1 -0.581 1 -0.58 1 -0.580 3 -100.00 1 -1001 0 100.00 0 1000 0 - 1 -1000 1 -100.00 1 -100

Sheet1

0 0 100.00 0 1001 0 100.00 0 1004 2 0.11 1 0.81 1 -0.58 2 -1.280 1 -100.00 1 -1000 0 - 0 01 0 100.00 1 -0.581 1 -0.58 1 -0.580 1 -100.00 0 01 0 100.00 0 100

25 36 -0.95 27 -0.662 1 0.11 0 00 0 - 1 -1001 2 -1.28 1 -0.586 3 0.11 6 -0.580 0 - 0 01 2 -1.28 6 -2.371 0 100.00 0 1001 1 -0.58 1 -0.582 3 -0.99 1 0.110 0 - 0 02 2 -0.58 0 1002 1 0.11 0 1002 0 - 0 01 0 100.00 0 1001 2 -1.28 3 -1.683 1 0.52 1 0.522 0 100.00 0 1000 0 - 1 -1002 4 -1.28 2 -0.581 3 -1.68 4 -1.971 0 100.00 0 1000 0 - 0 01 1 -0.58 3 -1.682 0 100.00 0 1000 2 -100.00 1 -1002 3 -0.99 1 0.11

24 32 -0.87 24 -0.580 2 -100.00 1 -1000 0 - 1 -1003 1 0.52 1 0.524 7 -1.14 2 0.111 1 -0.58 1 -0.582 0 100.00 0 1000 0 - 0 01 0 100.00 0 1001 1 -0.58 0 1003 3 -0.58 1 0.520 0 - 0 00 0 - 0 00 2 -100.00 1 -1000 0 - 1 -1000 0 - 0 01 1 -0.58 0 1003 5 -1.09 12 -1.970 0 - 0 04 1 0.80 0 100

Sheet1

0 1 -100.00 0 06 0 100.00 0 1000 0 - 0 00 0 - 0 07 3 0.27 4 -0.024 3 -0.29 4 -0.580 0 - 0 00 0 - 1 -100

16 13 -0.37 15 -0.521 0 100.00 1 -0.587 4 -0.02 5 -0.250 0 - 0 00 2 -100.00 0 00 0 100.00 0 100

41 34 -0.40 43 -0.632 1 0.11 0 1000 0 - 0 00 2 -100.00 2 -1004 5 -0.81 3 -0.291 0 - 0 01 1 -0.58 1 -0.581 1 -0.58 1 -0.581 0 100.00 0 1001 0 100.00 0 1000 2 -100.00 0 00 0 - 0 02 1 0.11 0 1000 0 - 0 01 1 -0.58 2 -1.280 2 -100.00 0 00 0 - 0 01 2 -1.28 1 -0.580 0 - 0 02 0 100.00 0 1000 0 - 0 01 1 -0.58 1 -0.581 0 100.00 0 1001 0 100.00 0 1001 0 100.00 0 1000 0 - 1 -1002 0 100.00 0 1001 2 -1.28 1 -0.581 1 -0.58 0 1000 0 - 0 00 0 - 0 00 2 -100.00 2 -1002 5 -1.50 3 -0.991 0 100.00 0 1004 6 -0.99 2 0.110 0 - 0 01 0 100.00 0 1000 0 100.00 1 -1001 0 100.00 0 1001 2 -1.28 0 02 1 0.11 1 0.119 6 -0.18 2 0.920 1 -100.00 0 100

Sheet1

2 2 -0.58 0 1004 4 -0.58 6 -0.992 2 -0.58 3 -0.99

10 7 -0.23 8 -0.364 2 0.11 3 -0.290 0 - 0 00 0 - 0 00 0 - 0 00 0 - 0 04 2 0.11 3 -0.291 1 -0.58 0 1000 0 - 0 00 0 - 1 -1000 0 - 1 -1001 1 -0.58 1 -0.580 2 -100.00 2 -1000 0 - 3 -1002 1 0.11 2 -0.581 1 -0.58 1 -0.581 0 100.00 0 1001 1 -0.58 0 01 1 -0.58 2 -1.281 1 -0.58 1 -0.585 0 100.00 1 1.032 2 -0.58 1 0.110 0 - 1 -1000 0 - 0 00 0 - 0 01 0 100.00 0 1000 0 - 1 -1000 0 - 0 01 0 - 1 -0.580 0 - 0 00 0 100.00 0 1004 0 100.00 4 -0.580 0 - 0 02 0 100.00 0 1002 2 -0.58 3 -0.990 0 - 0 00 0 - 0 02 2 -0.58 2 -0.580 1 -100.00 0 01 2 -1.28 1 -0.580 0 - 1 -1000 0 100.00 0 1000 1 -100.00 0 00 1 -100.00 1 -1001 1 -0.58 0 1000 0 - 1 -1002 0 100.00 0 1002 0 100.00 0 1001 1 -0.58 2 -1.280 0 100.00 0 1001 0 - 1 -0.580 0 - 1 -1002 2 -0.58 1 0.11

73 76 -0.63 77 -0.64

Sheet1

1 6 -2.37 3 -1.681 0 100.00 0 1002 4 -1.28 3 -0.991 1 -0.58 0 1000 1 -100.00 0 00 0 - 0 00 0 - 1 -1002 0 100.00 0 1006 9 -0.99 8 -0.870 0 - 1 -1003 3 -0.58 5 -1.092 0 100.00 1 0.110 0 - 1 -1000 0 - 0 00 0 - 2 -1004 4 -0.58 3 -0.291 1 -0.58 0 00 0 - 0 03 0 100.00 0 100

19 15 -0.35 22 -0.736 5 -0.40 1 1.210 3 -100.00 0 00 0 100.00 0 1000 0 - 0 01 3 -1.68 1 -0.580 1 -100.00 0 01 1 -0.58 0 1002 3 -0.99 1 0.111 0 100.00 1 -0.580 0 - 0 01 0 100.00 1 -0.580 0 - 3 -1000 0 - 0 01 2 -1.28 2 -1.283 1 0.52 1 0.520 0 - 0 00 1 -100.00 1 -1001 1 -0.58 2 -1.281 1 -0.58 0 1001 0 - 0 01 2 -1.28 0 1000 0 - 0 02 0 100.00 0 1001 0 - 0 06 5 -0.40 4 -0.186 5 -0.40 3 0.111 0 100.00 0 1003 5 -1.09 4 -0.871 1 -0.58 1 -0.583 0 100.00 0 1001 2 -1.28 1 -0.587 5 -0.25 5 -0.250 0 - 1 -1003 2 -0.18 1 0.520 0 - 0 00 1 -100.00 0 00 0 - 1 -100

Sheet1

2 1 0.11 0 1000 3 -100.00 0 00 5 -100.00 0 00 0 - 0 01 1 -0.58 1 -0.580 2 -100.00 1 -1002 2 -0.58 2 -0.580 0 - 1 -1000 0 - 0 01 1 -0.58 0 1002 4 -1.28 3 -0.991 1 -0.58 1 -0.587 1 1.36 6 -0.432 4 -1.28 3 -0.992 1 0.11 1 0.111 1 -0.58 1 -0.582 1 0.11 1 0.110 3 -100.00 1 -1001 0 100.00 0 1000 0 - 0 02 2 -0.58 4 -1.281 0 - 0 00 0 - 0 00 4 -100.00 0 00 0 - 0 01 2 -1.28 1 -0.58

50 73 -0.97 77 -1.020 1 -100.00 0 01 1 -0.58 1 -0.581 1 -0.58 0 1003 1 0.52 2 -0.180 0 - 0 01 1 -0.58 1 -0.580 0 - 0 01 3 -1.68 3 -1.685 3 -0.07 3 -0.070 1 -100.00 0 01 1 -0.58 1 -0.586 5 -0.40 2 0.520 0 - 0 00 1 -100.00 2 -1002 1 0.11 2 -0.581 1 -0.58 1 -0.580 1 -100.00 0 1002 0 100.00 2 -0.581 0 100.00 1 -0.581 3 -1.68 4 -1.970 1 -100.00 0 05 3 -0.07 2 0.330 0 100.00 0 1000 0 - 0 01 1 -0.58 0 1002 2 -0.58 2 -0.580 0 100.00 0 1000 0 - 0 00 0 - 0 00 1 -100.00 0 0

Sheet1

0 1 -100.00 0 00 0 - 1 -1004 5 -0.81 4 -0.580 0 100.00 1 -100

14 16 -0.72 15 -0.651 1 -0.58 0 1001 1 -0.58 2 -1.281 1 -0.58 1 -0.581 1 -0.58 1 -0.581 2 -1.28 2 -1.280 1 -100.00 1 -1002 0 100.00 1 0.11

20 12 -0.07 13 -0.154 2 0.11 6 -0.991 0 100.00 3 -1.687 5 -0.25 3 0.260 0 - 0 05 3 -0.07 2 0.331 1 -0.58 0 1000 0 - 0 05 1 1.03 0 1001 0 100.00 0 1002 1 0.11 3 -0.994 2 0.11 2 0.110 0 - 0 01 1 -0.58 1 -0.581 0 100.00 1 -0.581 0 100.00 0 1001 0 100.00 0 1001 0 100.00 0 1000 0 - 0 03 3 -0.58 3 -0.581 1 -0.58 1 -0.583 1 0.52 0 1001 0 100.00 0 1000 0 - 1 -1001 0 100.00 0 1000 0 - 0 01 0 - 1 -0.581 1 -0.58 2 -1.285 7 -0.92 5 -0.585 3 -0.07 1 1.030 2 -100.00 1 -1002 1 0.11 0 01 1 -0.58 1 -0.581 0 100.00 0 1000 0 - 1 -1002 0 100.00 0 1000 0 - 0 0

10 8 -0.36 4 0.332 0 100.00 2 -0.581 0 100.00 1 -0.580 0 - 1 -1001 0 - 1 -0.581 1 -0.58 0 1000 1 -100.00 0 00 0 - 0 0

Sheet1

0 0 - 0 01 0 100.00 1 -0.580 0 100.00 0 1001 0 - 0 01 0 - 0 00 0 - 1 -1002 3 -0.99 3 -0.990 0 - 1 -1000 1 -100.00 1 -1001 1 -0.58 2 -1.280 1 -100.00 0 00 0 - 1 -1001 1 -0.58 1 -0.580 0 - 0 01 2 -1.28 1 -0.581 1 -0.58 1 -0.581 0 100.00 0 1001 0 - 0 00 0 - 0 00 0 - 2 -1001 1 -0.58 0 1001 2 -1.28 1 -0.583 2 -0.18 2 -0.180 1 -100.00 0 01 0 100.00 0 1001 2 -1.28 2 -1.286 7 -0.74 5 -0.40 0 - 1 -1002 2 -0.58 1 0.110 0 - 1 -1003 1 0.52 1 0.520 2 -100.00 0 00 0 - 0 00 1 -100.00 2 -1000 1 -100.00 0 06 2 0.52 2 0.523 2 -0.18 1 0.522 1 0.11 1 0.11

34 17 0.11 12 0.461 1 -0.58 0 1001 1 -0.58 1 -0.580 1 -100.00 0 01 0 100.00 1 -0.580 0 100.00 0 1000 0 100.00 1 -1001 0 100.00 0 1000 0 - 0 02 0 100.00 2 -0.580 0 100.00 0 1005 7 -0.92 6 -0.770 1 -100.00 0 01 0 100.00 3 -1.680 1 -100.00 0 06 5 -0.40 5 -0.40 0 100.00 0 1000 0 - 0 00 0 100.00 1 -100

Sheet1

0 0 - 1 -1000 0 - 0 00 0 - 0 00 2 -100.00 0 00 1 -100.00 0 00 1 -100.00 0 00 1 -100.00 2 -1001 1 -0.58 2 -1.281 2 -1.28 2 -1.281 0 100.00 0 1001 3 -1.68 1 -0.581 0 100.00 4 -1.970 0 - 0 00 1 -100.00 0 03 1 0.52 2 -0.182 3 -0.99 2 -0.581 0 100.00 0 1001 0 - 0 00 1 -100.00 2 -1000 2 -100.00 1 -1002 1 0.11 3 -0.990 0 - 0 01 1 -0.58 1 -0.580 1 -100.00 0 05 2 0.33 2 0.331 1 -0.58 0 09 2 0.92 0 1000 0 - 0 00 0 100.00 0 1001 1 -0.58 1 -0.581 1 -0.58 1 -0.582 2 -0.58 2 -0.580 0 - 0 02 1 0.11 2 -0.584 4 -0.58 2 0.111 0 - 0 00 0 - 0 00 0 - 0 01 0 100.00 0 1001 0 - 0 00 0 - 1 -1001 0 - 0 04 2 0.11 4 -0.580 0 100.00 0 1005 7 -0.92 2 0.331 0 - 0 05 2 0.33 1 1.030 0 - 1 -1001 1 -0.58 0 02 6 -1.68 4 -1.281 0 100.00 0 1002 1 0.11 2 -0.581 0 100.00 0 1000 1 -100.00 0 1000 0 - 1 -1001 0 - 0 00 1 -100.00 0 0

Sheet1

0 1 -100.00 1 -1004 4 -0.58 3 -0.296 9 -0.99 5 -0.40 0 100.00 0 1004 4 -0.58 3 -0.294 2 0.11 2 0.113 1 0.52 3 -0.581 0 100.00 0 1004 3 -0.29 1 0.82 2 -0.58 2 -0.580 0 - 0 00 0 - 0 01 1 -0.58 0 1002 1 0.11 1 0.110 0 - 0 00 0 - 1 -1001 0 100.00 0 1001 0 100.00 1 -0.589 10 -0.69 12 -0.871 0 - 1 -0.581 0 100.00 0 1001 2 -1.28 0 1000 0 100.00 0 1001 1 -0.58 0 1003 2 -0.18 1 0.522 1 0.11 1 0.115 4 -0.36 6 -0.770 1 -100.00 0 00 0 - 2 -1001 2 -1.28 0 1006 2 0.52 5 -0.42 3 -0.99 0 1000 0 - 0 01 1 -0.58 3 -1.680 1 -100.00 0 03 1 0.52 1 0.522 0 100.00 0 100

34 40 -0.75 33 -0.550 0 - 1 -1009 7 -0.33 7 -0.330 0 - 0 00 1 -100.00 1 -1003 0 100.00 1 0.520 0 - 0 00 2 -100.00 2 -1000 1 -100.00 1 -1007 6 -0.43 1 1.360 0 - 0 00 0 - 0 00 0 - 0 01 1 -0.58 1 -0.580 1 -100.00 0 00 0 - 1 -1000 0 - 0 00 1 -100.00 0 1001 0 100.00 0 1003 0 100.00 0 100

Sheet1

0 0 - 0 01 2 -1.28 0 1000 1 -100.00 0 1004 2 0.11 1 0.80 0 - 0 09 12 -0.87 15 -1.092 4 -1.28 4 -1.282 3 -0.99 4 -1.281 0 - 0 02 0 100.00 1 0.111 1 -0.58 0 1003 2 -0.18 3 -0.581 0 100.00 0 1000 0 - 0 00 0 - 0 00 0 - 0 00 0 100.00 2 -1003 5 -1.09 3 -0.580 0 - 0 01 1 -0.58 0 02 1 0.11 0 1001 0 100.00 0 1000 1 -100.00 0 02 0 100.00 1 0.110 0 - 0 00 0 - 1 -1000 1 -100.00 1 -1001 1 -0.58 1 -0.582 2 -0.58 4 -1.280 0 - 0 00 1 -100.00 2 -100

10 6 -0.07 5 0.111 2 -1.28 1 -0.582 4 -1.28 1 0.111 0 100.00 0 1002 1 0.11 2 -0.580 0 - 4 -1005 7 -0.92 3 -0.072 0 100.00 0 1000 0 - 0 03 2 -0.18 2 -0.180 0 100.00 0 1008 3 0.40 2 0.89 5 0.01 3 0.52

13 10 -0.32 6 0.191 1 -0.58 2 -1.280 0 - 0 00 2 -100.00 2 -1003 0 100.00 0 1001 2 -1.28 2 -1.281 1 -0.58 1 -0.582 3 -0.99 4 -1.280 0 - 0 01 1 -0.58 0 1001 1 -0.58 0 1001 1 -0.58 1 -0.580 0 - 0 0

Sheet1

1 1 -0.58 2 -1.282 0 100.00 0 1000 1 -100.00 0 1001 1 -0.58 0 1000 0 - 1 -1003 3 -0.58 1 0.522 1 0.11 3 -0.991 0 100.00 0 1008 5 -0.11 3 0.40 0 - 0 01 0 100.00 0 1002 1 0.11 1 0.11

10 1 1.72 3 0.622 2 -0.58 1 0.110 2 -100.00 1 -1001 0 100.00 0 1000 0 - 0 01 0 100.00 1 -0.581 0 100.00 0 1000 1 -100.00 0 00 0 - 1 -1001 4 -1.97 1 -0.580 0 - 1 -1001 1 -0.58 1 -0.580 0 - 0 02 1 0.11 4 -1.281 0 - 2 -1.283 2 -0.18 1 0.520 0 - 0 00 0 - 1 -1000 0 100.00 0 1001 0 100.00 1 -0.582 0 100.00 1 0.110 0 - 0 00 0 - 0 00 0 - 0 01 0 100.00 0 1001 2 -1.28 1 -0.586 4 -0.18 5 -0.40 0 - 1 -1000 1 -100.00 1 -1000 0 - 0 00 1 -100.00 1 -1003 2 -0.18 1 0.520 0 - 0 01 0 100.00 0 1005 5 -0.58 2 0.331 1 -0.58 1 -0.582 0 100.00 0 1001 0 - 0 00 1 -100.00 1 -1000 1 -100.00 0 00 0 - 0 00 0 100.00 0 1000 0 - 0 00 0 100.00 1 -100

15 2 1.43 4 0.74

Sheet1

1 0 100.00 1 -0.585 5 -0.58 2 0.330 2 -100.00 0 00 1 -100.00 0 00 1 -100.00 0 1002 1 0.11 1 0.110 0 100.00 0 1000 1 -100.00 0 1002 2 -0.58 1 0.110 0 - 1 -1001 0 100.00 1 -0.580 0 - 0 03 3 -0.58 3 -0.580 1 -100.00 1 -1000 0 - 0 01 1 -0.58 0 1002 2 -0.58 1 0.110 0 - 1 -1000 1 -100.00 1 -1000 0 - 0 00 0 - 0 00 3 -100.00 2 -1002 3 -0.99 3 -0.992 0 - 0 00 0 - 0 03 2 -0.18 2 -0.180 0 100.00 1 -1000 2 -100.00 2 -1000 1 -100.00 1 -1000 0 - 0 00 0 100.00 0 1000 0 - 0 01 0 100.00 1 -0.582 3 -0.99 1 0.110 0 100.00 0 1002 1 0.11 3 -0.990 0 - 1 -1000 0 - 0 01 0 100.00 0 1000 0 - 0 02 1 0.11 1 0.110 0 - 0 01 0 100.00 0 1000 0 100.00 1 -1000 1 -100.00 2 -1001 1 -0.58 0 1001 1 -0.58 1 -0.586 8 -0.87 1 1.211 1 -0.58 0 1001 2 -1.28 0 1000 0 - 0 00 1 -100.00 0 02 1 0.11 1 0.110 0 - 1 -1000 0 - 0 00 0 100.00 1 -1000 0 - 2 -100

Sheet1

1 3 -1.68 2 -1.2810 5 0.11 8 -0.360 1 -100.00 0 00 0 - 0 00 0 - 0 00 0 - 0 00 3 -100.00 1 -1000 1 -100.00 0 00 0 - 0 03 2 -0.18 0 1000 1 -100.00 1 -1003 0 100.00 2 -0.182 1 0.11 1 0.110 2 -100.00 0 1000 1 -100.00 0 03 4 -0.87 3 -0.580 0 - 0 00 1 -100.00 0 01 0 - 0 00 0 - 0 02 0 100.00 0 1002 2 -0.58 2 -0.582 1 0.11 0 1002 1 0.11 1 0.111 0 - 1 -0.580 0 - 1 -1000 1 -100.00 0 00 0 - 0 00 0 - 0 01 1 -0.58 0 1002 6 -1.68 5 -1.50 1 -100.00 0 01 2 -1.28 2 -1.281 1 -0.58 1 -0.580 1 -100.00 0 02 1 0.11 1 0.111 1 -0.58 3 -1.681 0 100.00 1 -0.581 0 100.00 0 1004 2 0.11 1 0.81 0 100.00 1 -0.580 0 - 0 00 0 - 0 00 1 -100.00 0 02 0 100.00 0 1001 1 -0.58 0 1000 0 - 0 01 1 -0.58 2 -1.281 1 -0.58 2 -1.280 0 100.00 0 1001 1 -0.58 0 1001 1 -0.58 0 02 1 0.11 4 -1.281 1 -0.58 1 -0.584 1 0.80 2 0.110 1 -100.00 0 02 1 0.11 1 0.11

Sheet1

0 1 -100.00 0 09 0 100.00 3 0.522 0 100.00 0 1000 1 -100.00 0 01 0 - 0 00 0 - 1 -1001 0 100.00 0 1000 0 - 0 09 15 -1.09 18 -1.281 0 100.00 1 -0.580 0 - 0 00 0 - 0 00 0 - 0 00 0 - 0 00 0 - 1 -1001 1 -0.58 0 1000 1 -100.00 2 -1000 0 - 0 00 0 - 0 00 0 - 1 -1000 0 - 1 -1000 0 - 0 00 1 -100.00 0 02 0 100.00 0 1007 0 100.00 1 1.360 0 - 0 00 0 - 0 00 1 -100.00 0 00 0 100.00 3 -1000 1 -100.00 0 00 0 - 1 -1001 1 -0.58 1 -0.581 0 100.00 1 -0.581 0 100.00 0 1000 0 - 0 04 6 -0.99 3 -0.290 0 - 1 -1002 2 -0.58 2 -0.580 0 - 0 01 1 -0.58 0 1001 0 100.00 0 1002 0 100.00 0 1000 0 - 3 -1000 0 - 1 -1004 1 0.80 1 0.81 1 -0.58 1 -0.582 2 -0.58 2 -0.581 1 -0.58 2 -1.282 3 -0.99 3 -0.990 1 -100.00 0 01 0 100.00 1 -0.580 1 -100.00 0 01 0 100.00 0 1008 5 -0.11 14 -1.140 2 -100.00 0 00 0 - 2 -1000 1 -100.00 0 0

Sheet1

1 0 100.00 0 1003 4 -0.87 3 -0.580 0 - 0 01 0 100.00 0 1000 0 - 0 00 0 - 0 00 0 - 0 00 0 - 1 -1000 0 - 0 00 1 -100.00 1 -1000 0 - 0 03 5 -1.09 4 -0.872 0 100.00 0 1000 0 - 0 00 0 - 0 05 2 0.33 0 1001 1 -0.58 0 1000 1 -100.00 0 00 1 -100.00 1 -1005 7 -0.92 8 -1.053 3 -0.58 0 1002 1 0.11 2 -0.580 0 - 0 01 0 100.00 0 1001 2 -1.28 1 -0.581 0 100.00 1 -0.580 0 - 0 00 0 - 2 -1000 1 -100.00 0 00 0 - 0 01 0 100.00 0 1000 0 - 2 -1002 1 0.11 1 0.111 1 -0.58 0 1007 6 -0.43 3 0.267 3 0.27 1 1.360 1 -100.00 0 06 4 -0.18 2 0.522 0 100.00 0 1004 1 0.80 1 0.81 1 -0.58 0 00 0 - 0 01 2 -1.28 1 -0.584 4 -0.58 4 -0.580 0 - 1 -1000 1 -100.00 1 -1001 0 - 0 01 2 -1.28 1 -0.580 0 - 0 02 0 100.00 0 1002 1 0.11 0 1000 1 -100.00 0 00 0 - 0 01 0 100.00 1 -0.580 0 - 0 02 4 -1.28 3 -0.990 0 100.00 0 100

Sheet1

0 0 - 0 00 0 - 0 00 0 - 0 01 0 - 0 00 0 100.00 0 1000 0 - 0 00 1 -100.00 0 07 6 -0.43 6 -0.430 0 - 0 00 1 -100.00 1 -1000 0 - 0 01 1 -0.58 1 -0.582 0 - 1 0.116 2 0.52 4 -0.181 0 100.00 0 1000 0 100.00 0 1000 0 100.00 0 1002 2 -0.58 1 0.110 1 -100.00 0 00 1 -100.00 1 -1001 1 -0.58 0 1000 1 -100.00 0 0

12 10 -0.40 6 0.111 2 -1.28 0 1000 0 - 0 00 0 - 1 -1001 0 100.00 0 1000 0 - 0 03 2 -0.18 1 0.520 0 100.00 0 1000 0 - 0 06 4 -0.18 5 -0.42 1 0.11 0 1001 5 -2.19 0 1001 0 100.00 0 1008 1 1.50 1 1.50 0 - 0 00 1 -100.00 0 00 2 -100.00 2 -1000 0 - 0 08 9 -0.70 5 -0.111 1 -0.58 1 -0.580 0 - 0 01 2 -1.28 1 -0.580 0 - 1 -1000 1 -100.00 0 00 0 - 0 02 0 100.00 0 1000 0 - 0 00 0 - 1 -1001 0 100.00 0 1000 0 - 1 -1000 0 - 2 -1002 0 100.00 1 0.110 0 100.00 0 1002 2 -0.58 1 0.110 0 - 0 0

Sheet1

0 0 - 0 00 2 -100.00 0 00 1 -100.00 0 01 0 100.00 1 -0.581 1 -0.58 0 1005 6 -0.76 10 -1.280 0 - 2 -1003 0 100.00 3 -0.583 0 100.00 0 1000 0 - 0 00 2 -100.00 0 00 0 - 0 01 1 -0.58 3 -1.681 0 100.00 0 1000 1 -100.00 1 -1003 1 0.52 0 1000 1 -100.00 0 00 0 100.00 0 1004 4 -0.58 2 0.110 0 - 0 05 11 -1.37 4 -0.360 1 -100.00 1 -1001 0 100.00 0 1000 1 -100.00 0 00 0 - 0 03 7 -1.43 1 0.520 0 - 0 00 0 100.00 1 -1001 0 100.00 0 1001 0 - 0 03 1 0.52 1 0.521 1 -0.58 1 -0.580 0 - 0 02 1 0.11 3 -0.991 2 -1.28 2 -1.280 0 - 1 -1002 1 0.11 0 1000 0 - 2 -1002 0 100.00 0 1000 0 - 0 01 1 -0.58 1 -0.580 1 -100.00 1 -1000 0 - 0 0

15 11 -0.27 17 -0.711 1 -0.58 1 -0.581 0 100.00 0 1001 2 -1.28 2 -1.282 4 -1.28 1 0.110 0 - 0 00 0 - 0 01 1 -0.58 0 00 0 - 0 00 0 100.00 0 1000 0 - 0 01 1 -0.58 1 -0.581 1 -0.58 1 -0.581 0 100.00 0 100

Sheet1

0 0 - 0 00 0 - 0 00 0 - 1 -1002 2 -0.58 2 -0.581 0 100.00 0 1001 0 - 2 -1.280 0 - 0 01 0 100.00 0 1000 0 - 1 -1003 3 -0.58 3 -0.580 0 - 0 0

17 15 -0.46 16 -0.521 0 100.00 0 1001 1 -0.58 2 -1.281 0 100.00 0 1000 0 - 0 00 0 - 3 -1001 0 100.00 0 1001 2 -1.28 2 -1.280 0 100.00 0 1001 0 100.00 0 1002 2 -0.58 0 1000 1 -100.00 0 1005 7 -0.92 0 1000 0 - 0 01 0 100.00 0 1001 0 - 0 01 2 -1.28 0 1000 0 - 0 00 2 -100.00 0 00 0 - 3 -1000 1 -100.00 0 00 0 - 0 05 4 -0.36 3 -0.070 1 -100.00 0 01 1 -0.58 1 -0.581 1 -0.58 1 -0.585 0 100.00 1 1.030 0 - 1 -1001 0 100.00 1 -0.580 0 - 0 00 3 -100.00 0 00 1 -100.00 1 -1000 0 - 0 01 0 100.00 0 1002 0 100.00 1 0.115 9 -1.17 6 -0.770 0 - 0 00 1 -100.00 1 -1000 0 - 0 00 0 - 0 00 0 - 0 04 2 0.11 2 0.111 1 -0.58 1 -0.580 0 - 1 -1001 0 - 1 -0.581 1 -0.58 0 100

Sheet1

2 3 -0.99 3 -0.992 2 -0.58 2 -0.580 1 -100.00 1 -1003 5 -1.09 7 -1.433 3 -0.58 3 -0.580 1 -100.00 1 -1000 1 -100.00 1 -1000 0 - 0 00 0 - 1 -1001 0 100.00 1 -0.583 2 -0.18 0 1003 0 100.00 0 1001 0 100.00 0 1000 1 -100.00 1 -1005 4 -0.36 10 -1.28

10 7 -0.23 3 0.622 0 100.00 0 1001 1 -0.58 1 -0.580 0 - 0 01 5 -2.19 1 -0.583 4 -0.87 1 0.520 1 -100.00 0 01 3 -1.68 1 -0.581 2 -1.28 0 1001 0 - 0 01 0 100.00 0 1001 0 - 0 02 2 -0.58 0 1000 0 - 0 00 1 -100.00 0 01 0 100.00 1 -0.580 0 - 1 -1001 0 100.00 2 -1.282 2 -0.58 6 -1.682 2 -0.58 4 -1.280 0 - 0 03 2 -0.18 3 -0.580 1 -100.00 0 1000 0 100.00 1 -1003 12 -1.97 22 -2.588 9 -0.70 6 -0.291 0 100.00 2 -1.287 6 -0.43 4 -0.022 2 -0.58 2 -0.582 2 -0.58 5 -1.50 0 - 1 -1003 2 -0.18 3 -0.581 0 100.00 1 -0.584 3 -0.29 3 -0.294 4 -0.58 4 -0.587 7 -0.58 1 1.361 0 100.00 0 1004 4 -0.58 3 -0.292 2 -0.58 1 0.111 3 -1.68 1 -0.581 1 -0.58 0 01 0 100.00 1 -0.58

Sheet1

1 4 -1.97 3 -1.680 2 -100.00 1 -1001 1 -0.58 0 01 0 100.00 0 1000 0 - 0 01 0 - 1 -0.580 0 - 0 00 0 - 0 00 0 - 1 -1001 4 -1.97 2 -1.280 1 -100.00 1 -1001 0 100.00 0 1002 2 -0.58 4 -1.280 0 - 0 02 0 100.00 0 1001 0 100.00 0 1004 6 -0.99 3 -0.291 2 -1.28 0 0

13 14 -0.66 4 0.61 0 100.00 0 1001 0 100.00 1 -0.585 7 -0.92 5 -0.582 4 -1.28 5 -1.50 1 -100.00 2 -1000 2 -100.00 1 -1001 1 -0.58 1 -0.581 2 -1.28 2 -1.282 1 0.11 1 0.110 1 -100.00 0 1001 1 -0.58 2 -1.281 0 100.00 0 1000 0 - 0 00 0 - 0 00 0 - 0 00 0 - 0 02 1 0.11 1 0.110 0 - 0 00 0 - 0 00 0 100.00 1 -1001 0 100.00 0 1000 1 -100.00 0 00 0 - 1 -1000 0 - 0 00 0 - 0 01 1 -0.58 0 1000 1 -100.00 0 02 1 0.11 0 1000 0 - 1 -100

10 5 0.11 6 -0.070 0 - 1 -1001 0 100.00 0 1000 1 -100.00 0 00 0 - 0 00 0 - 1 -1002 0 100.00 0 1000 0 100.00 0 1000 0 - 0 0

Sheet1

0 0 - 1 -1000 1 -100.00 1 -1000 0 100.00 0 1001 1 -0.58 3 -1.681 2 -1.28 3 -1.680 0 - 0 00 0 - 0 01 0 100.00 0 1000 1 -100.00 0 00 1 -100.00 1 -1000 0 - 0 0

32 27 -0.41 17 0.0519 15 -0.35 22 -0.7331 26 -0.41 21 -0.1918 14 -0.33 20 -0.6913 17 -0.85 15 -0.7312 14 -0.74 12 -0.585 5 -0.58 5 -0.585 9 -1.17 13 -1.54

54 67 -0.80 63 -0.7433 37 -0.70 30 -0.492 2 -0.58 0 1000 0 100.00 0 1004 3 -0.29 2 0.110 0 100.00 0 1000 0 - 1 -1001 0 100.00 1 -0.581 2 -1.28 2 -1.280 1 -100.00 1 -1000 0 - 1 -1000 1 -100.00 0 00 0 100.00 2 -1000 0 - 1 -1003 2 -0.18 1 0.520 0 - 0 02 0 100.00 0 1001 0 - 1 -0.580 0 - 0 0

11 6 0.02 9 -0.385 3 -0.07 3 -0.075 4 -0.36 5 -0.58

200 134 -0.18 96 0.150 0 100.00 1 -1001 2 -1.28 1 -0.580 1 -100.00 0 01 1 -0.58 2 -1.281 3 -1.68 2 -1.28

158 124 -0.34 88 02 2 -0.58 4 -1.281 1 -0.58 0 1000 2 -100.00 2 -100

118 122 -0.62 128 -0.679 13 -0.95 7 -0.336 4 -0.18 4 -0.180 0 - 1 -1001 0 - 2 -1.286 3 0.11 6 -0.58

Sheet1

6 4 -0.18 4 -0.1813 11 -0.42 12 -0.51 0 100.00 0 1003 4 -0.87 3 -0.582 0 100.00 0 1001 2 -1.28 2 -1.280 1 -100.00 0 100

24 24 -0.58 68 -1.631 0 - 0 00 0 - 0 01 3 -1.68 1 -0.58

190 201 -0.65 189 -0.590 0 - 0 0

31 33 -0.65 24 -0.338 12 -0.99 12 -0.991 1 -0.58 1 -0.58

122 114 -0.52 113 -0.5110 11 -0.68 8 -0.3621 9 0.27 11 0.063 4 -0.87 3 -0.587 1 1.36 1 1.36

26 38 -0.96 26 -0.582 4 -1.28 4 -1.28

22 35 -1.05 25 -0.715 1 1.03 80 -3.36

85 105 -0.80 83 -0.561 1 -0.58 1 -0.583 0 100.00 1 0.526 6 -0.58 11 -1.196 5 -0.40 9 -0.990 0 100.00 0 1000 0 - 0 00 0 100.00 0 1004 6 -0.99 7 -1.140 3 -100.00 0 1004 1 0.80 5 -0.813 1 0.52 3 -0.582 2 -0.58 3 -0.992 5 -1.50 1 0.116 3 0.11 2 0.520 1 -100.00 2 -1000 0 - 0 00 0 - 0 02 3 -0.99 3 -0.992 2 -0.58 1 0.111 1 -0.58 0 02 0 100.00 0 1008 1 1.50 4 0.110 1 -100.00 0 04 3 -0.29 3 -0.290 0 - 1 -1001 0 100.00 2 -1.281 2 -1.28 3 -1.680 0 - 0 02 3 -0.99 1 0.114 1 0.80 2 0.112 1 0.11 1 0.11

Sheet1

1 1 -0.58 0 1002 1 0.11 0 1001 1 -0.58 1 -0.581 1 -0.58 1 -0.581 0 100.00 1 -0.58

23 24 -0.63 10 0.252 0 100.00 0 1001 1 -0.58 1 -0.581 1 -0.58 0 1001 1 -0.58 1 -0.580 0 - 1 -1001 2 -1.28 2 -1.281 0 100.00 0 1002 1 0.11 2 -0.585 2 0.33 1 1.030 2 -100.00 1 -1000 0 - 0 00 2 -100.00 1 -1003 2 -0.18 2 -0.180 2 -100.00 1 -1001 0 100.00 1 -0.580 0 - 0 02 2 -0.58 1 0.110 0 - 1 -1003 0 100.00 1 0.524 2 0.11 0 1001 1 -0.58 0 1002 1 0.11 2 -0.581 0 - 0 01 0 100.00 0 1003 1 0.52 1 0.523 2 -0.18 1 0.521 1 -0.58 0 03 2 -0.18 2 -0.180 0 - 0 00 0 - 0 07 2 0.67 5 -0.252 2 -0.58 1 0.111 1 -0.58 1 -0.581 0 100.00 0 1002 4 -1.28 1 0.111 1 -0.58 3 -1.68

17 17 -0.58 23 -0.891 0 100.00 0 1000 0 - 0 00 0 - 0 00 0 - 1 -1001 0 100.00 0 1000 0 - 0 01 1 -0.58 1 -0.582 1 0.11 1 0.110 0 - 0 01 1 -0.58 1 -0.580 1 -100.00 0 00 0 - 1 -1001 0 100.00 0 100

16 10 -0.11 5 0.58

Sheet1

2 2 -0.58 2 -0.581 0 100.00 0 1000 0 - 0 00 0 - 0 03 2 -0.18 2 -0.180 1 -100.00 1 -1001 0 100.00 0 1001 1 -0.58 1 -0.58

23 15 -0.15 10 0.250 0 100.00 0 1000 0 - 0 02 2 -0.58 1 0.112 2 -0.58 4 -1.280 0 - 0 00 1 -100.00 0 0

34 41 -0.77 50 -0.973 0 100.00 0 1001 0 100.00 3 -1.682 0 100.00 2 -0.580 0 - 0 00 0 - 0 00 0 - 0 00 0 - 0 00 0 - 0 00 1 -100.00 0 01 2 -1.28 1 -0.583 0 100.00 0 1002 0 100.00 1 0.111 0 100.00 0 1001 0 100.00 0 1003 1 0.52 1 0.520 1 -100.00 0 01 0 100.00 0 1009 4 0.23 3 0.521 2 -1.28 2 -1.28

31 32 -0.62 24 -0.330 0 - 0 0

12 8 -0.18 4 0.5241 46 -0.70 43 -0.631 1 -0.58 1 -0.580 0 - 0 00 1 -100.00 0 00 2 -100.00 1 -1001 1 -0.58 0 1002 0 100.00 3 -0.991 1 -0.58 1 -0.588 3 0.40 3 0.4

14 17 -0.78 19 -0.891 0 100.00 0 1000 0 - 0 01 2 -1.28 1 -0.581 0 100.00 0 1002 1 0.11 2 -0.580 0 - 0 00 1 -100.00 0 00 0 100.00 0 1000 0 - 0 0

Sheet1

3 3 -0.58 2 -0.181 1 -0.58 1 -0.581 2 -1.28 2 -1.283 6 -1.28 3 -0.58

19 12 -0.12 40 -1.332 2 -0.58 2 -0.582 0 - 1 0.110 2 -100.00 2 -1001 0 100.00 0 1000 0 - 0 01 1 -0.58 1 -0.581 1 -0.58 0 100

21 25 -0.76 19 -0.480 0 - 0 01 2 -1.28 3 -1.680 0 - 0 04 7 -1.14 2 0.111 2 -1.28 1 -0.582 1 0.11 2 -0.580 0 - 0 00 0 - 0 00 1 -100.00 0 00 0 - 0 05 0 100.00 0 1000 1 -100.00 2 -1001 0 100.00 0 1001 2 -1.28 0 1001 1 -0.58 2 -1.283 2 -0.18 3 -0.581 1 -0.58 1 -0.581 0 - 0 01 1 -0.58 0 1000 0 - 0 00 1 -100.00 0 00 1 -100.00 2 -1000 0 - 0 00 3 -100.00 3 -1001 1 -0.58 1 -0.581 1 -0.58 0 1001 2 -1.28 1 -0.580 0 100.00 1 -1000 1 -100.00 0 03 2 -0.18 2 -0.180 0 - 0 02 0 100.00 4 -1.282 2 -0.58 1 0.114 2 0.11 3 -0.293 2 -0.18 4 -0.873 2 -0.18 2 -0.180 0 - 0 00 0 - 0 02 3 -0.99 3 -0.99

40 27 -0.19 26 -0.1526 18 -0.21 17 -0.160 1 -100.00 1 -1001 2 -1.28 1 -0.580 0 - 0 0

Sheet1

0 0 - 0 01 1 -0.58 0 1001 0 100.00 0 1002 2 -0.58 2 -0.581 2 -1.28 0 1004 1 0.80 3 -0.295 10 -1.28 7 -0.92

54 56 -0.62 75 -0.9246 21 0.20 34 -0.283 3 -0.58 1 0.520 3 -100.00 2 -1002 0 100.00 0 1003 1 0.52 2 -0.180 0 100.00 0 1001 0 - 0 00 0 - 1 -1008 7 -0.45 7 -0.451 0 100.00 2 -1.283 2 -0.18 2 -0.184 1 0.80 2 0.113 2 -0.18 4 -0.871 0 - 1 -0.580 0 - 1 -1000 2 -100.00 1 -1001 1 -0.58 0 100

23 16 -0.22 17 -0.280 0 100.00 0 1001 0 100.00 1 -0.581 0 100.00 0 1001 0 - 0 01 2 -1.28 1 -0.583 2 -0.18 1 0.520 0 100.00 0 1001 0 - 1 -0.580 1 -100.00 0 08 7 -0.45 6 -0.291 0 100.00 0 1006 7 -0.74 5 -0.42 2 -0.58 2 -0.582 3 -0.99 4 -1.280 1 -100.00 0 00 1 -100.00 0 01 2 -1.28 0 00 1 -100.00 1 -1000 0 - 0 00 0 - 0 01 1 -0.58 0 1001 0 100.00 0 1000 0 - 0 01 1 -0.58 0 01 0 100.00 0 1000 0 - 0 00 0 - 0 00 0 - 1 -1000 0 - 0 00 0 - 0 00 0 - 0 0

Sheet1

2 2 -0.58 4 -1.282 1 0.11 1 0.112 2 -0.58 3 -0.990 0 - 1 -1001 0 100.00 1 -0.582 1 0.11 3 -0.993 5 -1.09 5 -1.090 0 - 0 02 5 -1.50 3 -0.991 1 -0.58 0 1002 2 -0.58 1 0.112 2 -0.58 1 0.112 1 0.11 1 0.111 1 -0.58 0 01 2 -1.28 2 -1.281 3 -1.68 3 -1.681 1 -0.58 1 -0.580 0 - 0 01 1 -0.58 1 -0.580 0 - 0 01 1 -0.58 0 01 1 -0.58 0 01 4 -1.97 1 -0.582 0 100.00 0 1002 1 0.11 1 0.111 0 100.00 0 1000 0 100.00 1 -1000 0 - 1 -1002 0 100.00 0 1000 0 - 1 -1001 0 100.00 0 1000 0 - 0 00 1 -100.00 1 -1000 1 -100.00 0 02 1 0.11 0 1000 0 - 2 -1003 0 100.00 3 -0.580 1 -100.00 0 00 0 - 0 02 1 0.11 2 -0.581 0 100.00 0 1001 0 100.00 1 -0.580 1 -100.00 2 -1006 4 -0.18 7 -0.740 0 - 0 01 1 -0.58 1 -0.580 0 - 0 00 0 - 0 00 0 - 0 00 0 100.00 0 1000 0 - 1 -1000 0 - 0 01 1 -0.58 0 1001 0 - 0 00 0 100.00 0 1002 2 -0.58 3 -0.990 0 - 0 0

Sheet1

2 1 0.11 1 0.111 3 -1.68 0 1002 1 0.11 2 -0.581 1 -0.58 1 -0.582 3 -0.99 4 -1.283 2 -0.18 2 -0.182 1 0.11 1 0.112 1 0.11 1 0.112 0 100.00 1 0.112 1 0.11 2 -0.583 1 0.52 1 0.523 1 0.52 2 -0.180 0 - 0 02 4 -1.28 2 -0.583 4 -0.87 2 -0.182 0 100.00 1 0.112 0 100.00 2 -0.581 1 -0.58 1 -0.580 0 - 0 00 0 - 0 00 0 - 0 00 0 - 0 01 1 -0.58 2 -1.281 1 -0.58 1 -0.586 4 -0.18 3 0.110 1 -100.00 1 -1001 1 -0.58 0 01 0 100.00 0 1000 0 - 0 00 0 - 0 00 1 -100.00 0 1002 0 100.00 0 1000 0 - 0 00 2 -100.00 0 01 0 100.00 0 1002 0 100.00 1 0.113 5 -1.09 3 -0.584 6 -0.99 1 0.81 0 100.00 0 1001 0 100.00 2 -1.280 0 - 0 01 0 - 1 -0.580 0 - 0 00 1 -100.00 0 03 1 0.52 0 100

30 29 -0.55 15 0.1196 87 -0.49 58 -0.083 7 -1.43 6 -1.281 1 -0.58 3 -1.681 1 -0.58 2 -1.28

10 7 -0.23 6 -0.070 2 -100.00 1 -1001 2 -1.28 1 -0.582 4 -1.28 2 -0.581 1 -0.58 0 1001 1 -0.58 1 -0.582 2 -0.58 3 -0.99

Sheet1

0 1 -100.00 1 -1000 0 - 0 00 5 -100.00 1 -1000 1 -100.00 1 -1000 0 - 0 00 0 - 0 02 0 100.00 0 1003 0 100.00 2 -0.181 2 -1.28 0 1001 0 100.00 2 -1.280 0 - 1 -1001 3 -1.68 3 -1.686 4 -0.18 9 -0.991 3 -1.68 3 -1.681 2 -1.28 1 -0.585 1 1.03 0 1007 10 -0.94 9 -0.839 13 -0.95 9 -0.58

10 12 -0.77 8 -0.3641 37 -0.48 43 -0.6336 39 -0.66 40 -0.691 1 -0.58 1 -0.580 2 -100.00 0 01 2 -1.28 1 -0.586 4 -0.18 8 -0.870 0 - 0 01 0 100.00 0 1000 0 - 0 01 0 100.00 0 1001 0 100.00 0 1002 0 100.00 0 1000 0 - 0 00 1 -100.00 0 01 1 -0.58 1 -0.580 1 -100.00 1 -1007 11 -1.03 7 -0.583 3 -0.58 1 0.52

18 10 0.01 7 0.363 2 -0.18 1 0.521 1 -0.58 1 -0.58

27 22 -0.38 10 0.411 0 100.00 0 1005 10 -1.28 6 -0.777 2 0.67 5 -0.251 0 100.00 0 1001 3 -1.68 3 -1.683 3 -0.58 1 0.522 2 -0.58 0 1007 8 -0.72 1 1.362 4 -1.28 3 -0.992 3 -0.99 0 100

13 16 -0.79 10 -0.320 0 - 0 03 1 0.52 3 -0.584 3 -0.29 1 0.82 4 -1.28 5 -1.51 0 100.00 0 100

Sheet1

3 1 0.52 0 1000 0 - 1 -1001 0 100.00 0 1000 0 100.00 1 -1006 2 0.52 3 0.112 1 0.11 1 0.112 1 0.11 4 -1.282 0 100.00 1 0.110 1 -100.00 0 01 2 -1.28 4 -1.970 1 -100.00 0 00 2 -100.00 0 01 0 100.00 0 1001 0 100.00 1 -0.580 1 -100.00 1 -1000 0 - 0 03 3 -0.58 3 -0.581 2 -1.28 0 1000 1 -100.00 2 -1002 1 0.11 1 0.111 1 -0.58 1 -0.580 0 - 0 0

29 13 0.22 20 -0.212 1 0.11 1 0.111 1 -0.58 1 -0.581 1 -0.58 1 -0.581 2 -1.28 2 -1.281 2 -1.28 3 -1.681 0 100.00 0 1001 1 -0.58 1 -0.581 1 -0.58 1 -0.582 1 0.11 0 1001 0 100.00 1 -0.581 1 -0.58 2 -1.281 0 100.00 0 1001 1 -0.58 1 -0.580 0 - 0 05 4 -0.36 2 0.332 5 -1.50 4 -1.282 2 -0.58 1 0.110 0 - 0 00 0 - 0 00 0 - 1 -1000 1 -100.00 0 1003 3 -0.58 3 -0.580 1 -100.00 0 00 1 -100.00 1 -1001 2 -1.28 1 -0.580 0 - 1 -1000 0 - 0 01 0 100.00 0 1001 1 -0.58 2 -1.280 0 - 0 00 0 - 0 02 0 100.00 1 0.111 0 100.00 1 -0.581 1 -0.58 1 -0.58

Sheet1

0 1 -100.00 0 01 0 100.00 0 1001 0 100.00 0 1001 0 100.00 0 1002 2 -0.58 2 -0.582 3 -0.99 3 -0.993 0 100.00 2 -0.181 1 -0.58 0 1001 0 100.00 1 -0.581 3 -1.68 1 -0.583 1 0.52 2 -0.181 0 100.00 3 -1.689 3 0.52 2 0.921 1 -0.58 1 -0.581 0 - 1 -0.580 0 - 0 00 0 - 1 -1000 0 - 1 -100

12 6 0.11 6 0.111 1 -0.58 2 -1.280 0 100.00 1 -1000 0 - 0 0

14 14 -0.58 11 -0.341 3 -1.68 1 -0.586 4 -0.18 1 1.210 0 - 0 0

14 12 -0.43 12 -0.433 0 100.00 0 100

50 16 0.56 20 0.330 0 - 0 05 6 -0.76 6 -0.770 0 - 1 -1003 1 0.52 3 -0.580 1 -100.00 1 -1001 0 100.00 0 1002 0 - 0 00 1 -100.00 0 01 0 100.00 0 1001 0 100.00 0 1005 3 -0.07 3 -0.070 0 - 0 08 5 -0.11 4 0.110 0 - 1 -1000 0 - 0 08 12 -0.99 9 -0.70 0 - 0 02 2 -0.58 3 -0.991 1 -0.58 1 -0.580 0 100.00 0 1003 2 -0.18 2 -0.186 7 -0.74 6 -0.580 0 - 1 -1001 1 -0.58 1 -0.581 1 -0.58 1 -0.582 1 0.11 1 0.112 1 0.11 1 0.116 3 0.11 6 -0.58

Sheet1

6 13 -1.36 14 -1.431 0 100.00 0 1001 0 100.00 0 1000 0 100.00 0 1001 0 100.00 0 1000 1 -100.00 1 -1003 5 -1.09 3 -0.583 5 -1.09 5 -1.097 10 -0.94 10 -0.940 1 -100.00 2 -100

11 9 -0.38 13 -0.751 2 -1.28 0 100

13 11 -0.42 13 -0.586 11 -1.19 10 -1.09

11 8 -0.26 13 -0.7515 18 -0.77 21 -0.922 2 -0.58 3 -0.990 1 -100.00 0 01 1 -0.58 1 -0.582 3 -0.99 2 -0.580 0 - 0 00 0 - 0 00 1 -100.00 0 01 0 100.00 0 1001 1 -0.58 0 1001 0 100.00 0 1001 2 -1.28 2 -1.280 1 -100.00 0 00 0 - 1 -1001 0 100.00 0 1001 0 100.00 0 1001 0 100.00 0 1001 1 -0.58 0 01 1 -0.58 1 -0.580 1 -100.00 0 02 1 0.11 2 -0.581 0 100.00 0 1000 1 -100.00 1 -1001 1 -0.58 0 100

122 145 -0.76 138 -0.712 1 0.11 0 1002 0 100.00 0 1001 1 -0.58 0 1000 0 - 0 00 0 - 0 02 1 0.11 0 1000 0 - 0 00 0 - 1 -1001 0 - 0 01 1 -0.58 2 -1.282 2 -0.58 1 0.112 1 0.11 2 -0.581 2 -1.28 1 -0.580 0 - 0 07 5 -0.25 6 -0.431 1 -0.58 1 -0.581 1 -0.58 1 -0.58

Sheet1

0 0 - 0 00 0 100.00 0 1000 0 100.00 0 1003 2 -0.18 4 -0.870 0 100.00 0 1000 3 -100.00 1 -1002 0 100.00 0 1003 2 -0.18 1 0.520 1 -100.00 0 0

17 3 1.15 8 0.175 7 -0.92 8 -1.053 2 -0.18 1 0.523 4 -0.87 3 -0.581 2 -1.28 1 -0.580 1 -100.00 0 02 1 0.11 2 -0.581 2 -1.28 2 -1.280 0 - 0 01 1 -0.58 1 -0.581 0 100.00 1 -0.581 1 -0.58 0 1002 2 -0.58 1 0.110 1 -100.00 1 -1000 1 -100.00 0 1000 0 - 0 01 0 100.00 0 1003 0 100.00 1 0.521 1 -0.58 1 -0.58

12 18 -0.99 15 -0.811 0 - 0 00 0 - 0 00 0 100.00 1 -1002 1 0.11 2 -0.581 3 -1.68 4 -1.971 1 -0.58 1 -0.581 1 -0.58 2 -1.285 4 -0.36 5 -0.582 2 -0.58 2 -0.587 3 0.27 4 -0.02

11 5 0.21 7 -0.130 0 - 0 02 2 -0.58 3 -0.990 0 - 0 00 0 - 1 -1002 0 100.00 0 1003 2 -0.18 1 0.522 2 -0.58 2 -0.583 4 -0.87 3 -0.584 2 0.11 1 0.83 0 100.00 1 0.521 2 -1.28 1 -0.582 1 0.11 0 1001 1 -0.58 0 1001 1 -0.58 1 -0.580 0 - 0 01 0 100.00 2 -1.280 0 - 2 -100

Sheet1

0 1 -100.00 0 02 1 0.11 0 1000 0 - 0 03 2 -0.18 2 -0.181 1 -0.58 1 -0.581 1 -0.58 1 -0.583 2 -0.18 2 -0.180 1 -100.00 1 -1000 1 -100.00 0 02 0 100.00 1 0.111 1 -0.58 1 -0.580 0 - 1 -1000 0 - 0 03 1 0.52 1 0.528 6 -0.29 0 1004 4 -0.58 3 -0.291 1 -0.58 1 -0.582 3 -0.99 1 0.111 0 - 1 -0.580 1 -100.00 1 -1000 0 - 0 00 1 -100.00 1 -1001 0 100.00 0 1003 3 -0.58 1 0.520 1 -100.00 1 -100

11 4 0.43 2 1.122 3 -0.99 3 -0.991 1 -0.58 3 -1.684 3 -0.29 2 0.110 0 - 0 02 1 0.11 1 0.111 1 -0.58 0 1001 0 100.00 1 -0.583 1 0.52 2 -0.181 0 100.00 1 -0.581 1 -0.58 0 1004 3 -0.29 4 -0.581 1 -0.58 4 -1.974 4 -0.58 1 0.80 1 -100.00 0 02 1 0.11 1 0.111 2 -1.28 1 -0.58

37 22 -0.06 25 -0.192 2 -0.58 0 1006 3 0.11 7 -0.741 0 - 1 -0.581 1 -0.58 1 -0.581 0 - 0 01 1 -0.58 1 -0.581 1 -0.58 1 -0.580 1 -100.00 0 1004 4 -0.58 4 -0.580 0 - 1 -1002 4 -1.28 3 -0.991 1 -0.58 1 -0.580 1 -100.00 1 -1002 4 -1.28 3 -0.99

Sheet1

0 0 - 0 00 1 -100.00 2 -1001 1 -0.58 0 1001 0 100.00 0 1003 3 -0.58 2 -0.180 1 -100.00 0 03 3 -0.58 2 -0.183 1 0.52 0 1000 0 - 1 -1006 7 -0.74 5 -0.42 1 0.11 2 -0.582 3 -0.99 1 0.116 5 -0.40 5 -0.43 2 -0.18 2 -0.18

18 14 -0.33 19 -0.641 1 -0.58 2 -1.280 2 -100.00 2 -1000 1 -100.00 0 1001 0 100.00 1 -0.585 8 -1.05 7 -0.920 0 - 1 -1001 0 100.00 0 1003 3 -0.58 1 0.523 1 0.52 0 1002 1 0.11 0 100

72 51 -0.24 85 -0.750 1 -100.00 1 -1001 1 -0.58 1 -0.58

38 36 -0.53 47 -0.81 2 -1.28 1 -0.581 1 -0.58 1 -0.582 1 0.11 0 1001 0 100.00 5 -2.190 0 - 0 05 3 -0.07 5 -0.580 1 -100.00 0 01 0 - 0 01 1 -0.58 1 -0.583 4 -0.87 1 0.520 0 - 0 0

10 12 -0.77 10 -0.583 0 100.00 0 1000 0 - 0 02 3 -0.99 1 0.110 0 - 0 01 0 100.00 0 1002 2 -0.58 1 0.111 1 -0.58 0 1000 1 -100.00 1 -1003 4 -0.87 1 0.521 2 -1.28 1 -0.581 0 - 0 01 1 -0.58 1 -0.580 1 -100.00 0 0

11 4 0.43 5 0.210 1 -100.00 0 01 4 -1.97 1 -0.58

Sheet1

1 2 -1.28 4 -1.971 1 -0.58 1 -0.582 2 -0.58 3 -0.999 8 -0.46 11 -0.781 1 -0.58 1 -0.58

22 27 -0.79 28 -0.831 0 100.00 1 -0.584 4 -0.58 6 -0.991 1 -0.58 0 1000 0 - 0 02 2 -0.58 2 -0.586 5 -0.40 3 0.112 1 0.11 1 0.112 2 -0.58 2 -0.580 0 - 1 -1000 0 - 0 02 1 0.11 1 0.110 1 -100.00 0 02 1 0.11 1 0.111 0 100.00 0 1000 0 - 1 -1002 1 0.11 1 0.110 1 -100.00 0 03 1 0.52 3 -0.585 8 -1.05 7 -0.921 0 100.00 1 -0.582 0 - 1 0.118 5 -0.11 4 0.111 0 100.00 0 1000 0 100.00 0 1000 1 -100.00 0 1000 0 - 0 00 0 - 1 -1004 4 -0.58 3 -0.292 2 -0.58 3 -0.993 2 -0.18 1 0.521 1 -0.58 2 -1.280 1 -100.00 0 01 2 -1.28 6 -2.371 1 -0.58 1 -0.580 0 100.00 3 -100

13 12 -0.50 8 -0.10 0 - 1 -1000 0 - 0 02 1 0.11 0 1001 2 -1.28 0 1000 1 -100.00 0 1002 1 0.11 2 -0.580 1 -100.00 0 1002 5 -1.50 1 0.110 0 - 0 01 1 -0.58 0 1001 0 100.00 0 1000 0 - 1 -1003 2 -0.18 1 0.520 0 - 1 -1002 1 0.11 0 100

Sheet1

2 1 0.11 2 -0.581 2 -1.28 2 -1.281 2 -1.28 1 -0.580 0 - 1 -1000 0 100.00 0 1005 2 0.33 3 -0.071 2 -1.28 2 -1.280 0 - 0 01 0 100.00 1 -0.581 1 -0.58 3 -1.683 1 0.52 2 -0.18

20 27 -0.88 21 -0.631 0 100.00 0 1001 0 100.00 1 -0.581 1 -0.58 1 -0.584 3 -0.29 4 -0.581 1 -0.58 2 -1.282 3 -0.99 1 0.110 3 -100.00 3 -1000 0 - 2 -1000 1 -100.00 0 01 2 -1.28 1 -0.58

12 13 -0.66 7 -0.048 7 -0.45 6 -0.292 1 0.11 1 0.111 0 100.00 3 -1.681 0 100.00 2 -1.280 0 - 0 00 0 - 0 05 2 0.33 3 -0.07

16 18 -0.70 18 -0.71 0 100.00 1 -0.580 0 - 0 01 0 100.00 3 -1.681 1 -0.58 2 -1.280 0 - 0 01 0 - 0 00 0 - 0 00 1 -100.00 1 -1001 2 -1.28 0 01 0 100.00 0 1000 0 - 2 -1000 0 100.00 1 -1000 1 -100.00 0 01 0 - 0 01 2 -1.28 1 -0.585 2 0.33 3 -0.073 4 -0.87 0 1002 3 -0.99 1 0.111 2 -1.28 3 -1.681 0 100.00 1 -0.581 1 -0.58 0 00 0 100.00 0 1000 2 -100.00 1 -1000 2 -100.00 0 01 0 - 0 01 1 -0.58 1 -0.58

Sheet1

7 5 -0.25 4 -0.022 3 -0.99 5 -1.51 0 100.00 0 1001 0 100.00 0 1000 0 - 1 -1000 0 - 1 -1001 0 100.00 0 1001 0 100.00 0 1001 0 100.00 3 -1.680 0 100.00 0 1000 1 -100.00 0 00 0 - 0 02 0 100.00 0 1001 0 - 0 00 1 -100.00 0 1002 1 0.11 0 1001 1 -0.58 0 1000 1 -100.00 0 1001 0 100.00 0 1000 1 -100.00 1 -1000 0 - 0 00 0 - 0 00 0 - 0 00 0 - 0 00 0 100.00 0 1002 2 -0.58 0 1001 0 100.00 1 -0.580 1 -100.00 0 1000 0 - 0 02 0 - 0 00 0 - 1 -1000 0 - 1 -1002 0 100.00 1 0.113 2 -0.18 3 -0.581 0 100.00 1 -0.580 1 -100.00 0 1000 0 100.00 2 -1000 1 -100.00 0 00 0 - 0 00 0 100.00 1 -1001 0 100.00 0 1000 2 -100.00 0 01 1 -0.58 0 01 0 100.00 0 1000 0 - 0 02 1 0.11 3 -0.991 0 - 0 06 3 0.11 2 0.520 0 - 0 00 0 - 0 02 1 0.11 0 1000 0 - 0 02 0 100.00 0 1000 1 -100.00 0 00 0 - 1 -1000 0 - 1 -1000 0 - 0 0

Sheet1

0 1 -100.00 0 1001 1 -0.58 2 -1.282 1 0.11 1 0.112 1 0.11 0 1002 0 100.00 1 0.112 0 100.00 1 0.110 1 -100.00 1 -1001 0 100.00 0 1000 1 -100.00 0 02 1 0.11 1 0.113 1 0.52 2 -0.180 0 - 1 -1000 0 - 0 01 1 -0.58 2 -1.281 1 -0.58 2 -1.281 1 -0.58 1 -0.581 0 100.00 3 -1.681 0 100.00 0 1000 1 -100.00 1 -1001 0 100.00 0 1000 0 - 0 01 0 100.00 0 1001 3 -1.68 3 -1.684 2 0.11 2 0.110 1 -100.00 3 -1002 3 -0.99 0 1002 1 0.11 1 0.110 0 - 0 00 0 - 0 01 0 100.00 1 -0.584 3 -0.29 0 1001 0 100.00 0 1000 0 - 0 00 0 - 0 01 1 -0.58 2 -1.281 5 -2.19 3 -1.683 3 -0.58 4 -0.874 3 -0.29 3 -0.290 1 -100.00 0 00 1 -100.00 1 -1002 1 0.11 0 1000 0 - 0 00 1 -100.00 0 01 0 100.00 1 -0.580 0 - 0 00 1 -100.00 0 01 2 -1.28 1 -0.580 0 - 0 01 0 100.00 0 1000 0 - 1 -1001 1 -0.58 0 1001 1 -0.58 0 00 1 -100.00 2 -1000 0 - 1 -1000 0 - 1 -1000 0 - 0 00 0 - 0 0

Sheet1

0 1 -100.00 0 00 0 - 0 00 0 - 0 00 0 - 0 02 2 -0.58 3 -0.991 0 100.00 0 1000 0 - 0 00 1 -100.00 0 06 4 -0.18 3 0.110 1 -100.00 2 -1000 1 -100.00 0 02 1 0.11 0 1000 0 - 1 -1000 0 - 0 00 0 100.00 0 1001 1 -0.58 3 -1.682 1 0.11 1 0.113 4 -0.87 1 0.520 0 - 0 00 0 - 0 00 1 -100.00 1 -1002 0 100.00 0 1001 3 -1.68 1 -0.580 0 - 1 -1000 0 - 0 00 1 -100.00 0 01 0 100.00 0 1001 0 100.00 0 1000 0 - 1 -1000 1 -100.00 0 0

12 9 -0.29 4 0.521 1 -0.58 1 -0.580 0 - 1 -1001 1 -0.58 1 -0.581 1 -0.58 1 -0.582 1 0.11 1 0.111 0 - 1 -0.580 0 100.00 0 1000 0 - 0 01 1 -0.58 2 -1.281 2 -1.28 1 -0.585 2 0.33 2 0.331 0 100.00 0 1000 0 - 0 02 0 100.00 1 0.110 1 -100.00 0 02 0 100.00 0 1003 4 -0.87 2 -0.181 0 100.00 0 1000 1 -100.00 0 04 0 100.00 2 0.111 1 -0.58 0 1001 1 -0.58 0 1001 0 100.00 0 1001 0 100.00 1 -0.583 2 -0.18 1 0.520 1 -100.00 0 100

Sheet1

1 0 100.00 0 1002 1 0.11 0 1000 2 -100.00 1 -1002 1 0.11 1 0.112 4 -1.28 2 -0.581 0 100.00 0 1005 3 -0.07 3 -0.073 2 -0.18 4 -0.872 1 0.11 3 -0.990 0 - 0 01 1 -0.58 1 -0.58

11 6 0.02 5 0.211 1 -0.58 2 -1.280 0 - 0 00 0 - 0 01 0 100.00 1 -0.582 2 -0.58 3 -0.990 0 - 0 00 0 - 0 01 2 -1.28 0 1000 0 100.00 0 1001 1 -0.58 1 -0.582 3 -0.99 2 -0.581 0 100.00 2 -1.280 0 - 0 00 0 100.00 0 1000 0 100.00 0 1000 0 - 1 -1001 0 100.00 1 -0.580 0 - 0 02 0 100.00 0 1000 2 -100.00 0 00 1 -100.00 0 1002 0 100.00 0 1001 0 100.00 1 -0.581 1 -0.58 1 -0.583 1 0.52 2 -0.180 0 - 0 01 1 -0.58 1 -0.580 1 -100.00 2 -1000 0 - 1 -1001 0 100.00 0 1001 0 100.00 2 -1.280 0 - 2 -1000 1 -100.00 0 00 0 - 3 -1001 1 -0.58 1 -0.582 0 100.00 0 1003 1 0.52 0 1000 0 - 0 03 1 0.52 1 0.521 1 -0.58 1 -0.586 5 -0.40 6 -0.583 3 -0.58 2 -0.180 1 -100.00 0 01 0 100.00 1 -0.580 0 - 1 -100

Sheet1

0 0 - 0 01 0 100.00 0 1000 1 -100.00 0 01 0 - 0 01 1 -0.58 0 1000 0 - 0 00 1 -100.00 0 00 0 - 0 01 0 - 0 00 0 - 0 00 0 - 1 -1002 2 -0.58 2 -0.581 0 100.00 0 1004 0 100.00 1 0.80 1 -100.00 0 1000 0 - 1 -1000 1 -100.00 1 -1001 0 100.00 0 1002 0 100.00 0 1008 4 0.11 4 0.111 0 100.00 2 -1.281 1 -0.58 1 -0.582 1 0.11 1 0.11

18 16 -0.47 13 -0.260 2 -100.00 1 -1000 0 - 0 02 1 0.11 0 1000 1 -100.00 0 00 0 - 0 01 0 100.00 0 1004 2 0.11 2 0.112 0 100.00 0 1000 0 - 1 -1001 0 100.00 0 1001 0 100.00 1 -0.580 1 -100.00 0 01 0 100.00 1 -0.580 0 100.00 0 1001 0 100.00 0 1000 0 - 0 00 0 - 0 00 0 - 1 -1000 1 -100.00 0 03 2 -0.18 1 0.520 0 - 0 00 2 -100.00 0 1004 1 0.80 2 0.111 0 100.00 0 1001 0 100.00 0 1004 2 0.11 0 1002 0 100.00 0 1002 0 100.00 0 1000 0 100.00 0 1000 1 -100.00 0 00 1 -100.00 0 00 0 100.00 0 1001 0 - 1 -0.58

Sheet1

1 1 -0.58 2 -1.281 1 -0.58 1 -0.580 1 -100.00 0 1000 0 - 0 03 2 -0.18 1 0.520 0 - 0 0

47 26 0.01 31 -0.171 0 100.00 0 1000 0 100.00 1 -1001 0 100.00 0 1000 2 -100.00 1 -1001 4 -1.97 2 -1.280 1 -100.00 0 01 0 100.00 0 1001 1 -0.58 2 -1.282 1 0.11 0 1000 2 -100.00 0 03 1 0.52 3 -0.582 0 100.00 2 -0.580 0 - 1 -1000 0 - 0 02 1 0.11 1 0.110 0 - 1 -1002 3 -0.99 3 -0.992 3 -0.99 3 -0.990 1 -100.00 1 -1000 0 - 1 -1000 0 100.00 0 1000 0 - 1 -1000 0 - 0 02 1 0.11 1 0.111 2 -1.28 1 -0.582 1 0.11 3 -0.991 2 -1.28 2 -1.282 0 100.00 1 0.110 1 -100.00 1 -1000 0 - 1 -1001 0 100.00 0 1005 5 -0.58 3 -0.074 3 -0.29 4 -0.582 2 -0.58 1 0.111 1 -0.58 1 -0.580 0 - 0 00 0 - 1 -1000 0 - 1 -1000 0 - 2 -1002 3 -0.99 2 -0.582 0 100.00 1 0.110 1 -100.00 0 01 0 100.00 2 -1.281 0 100.00 0 1001 1 -0.58 0 0

12 12 -0.58 7 -0.048 8 -0.58 5 -0.110 0 - 1 -1001 3 -1.68 3 -1.680 0 - 0 0

Sheet1

2 0 100.00 1 0.117 3 0.27 5 -0.251 0 100.00 0 1000 0 - 0 01 1 -0.58 0 1001 3 -1.68 1 -0.581 0 100.00 0 1006 5 -0.40 4 -0.180 0 - 0 01 1 -0.58 0 1000 0 - 0 01 1 -0.58 1 -0.582 0 100.00 0 1000 0 - 0 01 1 -0.58 1 -0.580 1 -100.00 0 03 2 -0.18 3 -0.588 5 -0.11 7 -0.458 10 -0.81 9 -0.71 0 100.00 1 -0.580 1 -100.00 0 01 2 -1.28 2 -1.281 0 100.00 0 1000 0 - 0 01 1 -0.58 2 -1.283 7 -1.43 2 -0.18

12 13 -0.66 11 -0.52 4 -1.28 3 -0.995 6 -0.76 6 -0.773 0 100.00 45 -3.30 0 - 0 05 3 -0.07 1 1.034 3 -0.29 3 -0.291 1 -0.58 1 -0.58

32 34 -0.64 87 -1.591 1 -0.58 0 01 2 -1.28 1 -0.580 2 -100.00 1 -1000 0 - 0 00 0 - 0 00 0 - 1 -1000 1 -100.00 1 -1000 0 - 1 -1000 1 -100.00 1 -1002 0 100.00 1 0.111 0 - 1 -0.580 0 - 0 01 1 -0.58 0 1001 2 -1.28 1 -0.580 0 - 0 02 2 -0.58 1 0.111 0 - 1 -0.580 1 -100.00 0 00 3 -100.00 1 -1000 0 - 0 00 0 - 1 -1001 1 -0.58 1 -0.58

Sheet1

0 0 - 0 01 1 -0.58 1 -0.581 2 -1.28 20 -3.582 1 0.11 0 1001 0 100.00 1 -0.580 0 - 1 -1000 0 100.00 0 1002 3 -0.99 1 0.112 3 -0.99 4 -1.28

18 21 -0.74 16 -0.4712 12 -0.58 10 -0.43 3 -0.58 3 -0.583 2 -0.18 2 -0.181 0 100.00 1 -0.581 1 -0.58 0 01 0 100.00 0 1000 1 -100.00 0 00 0 - 0 01 1 -0.58 1 -0.580 0 - 1 -1000 1 -100.00 0 1002 0 - 0 04 2 0.11 1 0.80 0 - 0 02 4 -1.28 2 -0.581 1 -0.58 3 -1.680 1 -100.00 1 -1001 1 -0.58 1 -0.581 2 -1.28 1 -0.580 0 - 0 03 2 -0.18 4 -0.870 0 - 0 03 2 -0.18 5 -1.091 1 -0.58 0 1002 1 0.11 1 0.115 1 1.03 2 0.330 1 -100.00 1 -1001 1 -0.58 0 1001 1 -0.58 0 02 1 0.11 1 0.110 1 -100.00 2 -1000 0 - 1 -1001 0 - 0 03 2 -0.18 1 0.522 2 -0.58 2 -0.582 1 0.11 2 -0.580 0 - 1 -1000 1 -100.00 0 01 0 - 0 00 0 - 0 00 1 -100.00 1 -100

40 59 -0.97 54 -0.893 3 -0.58 1 0.521 2 -1.28 3 -1.683 0 100.00 1 0.521 2 -1.28 1 -0.588 6 -0.29 9 -0.7

Sheet1

1 2 -1.28 2 -1.280 1 -100.00 1 -1001 0 100.00 0 1000 0 - 1 -1005 0 100.00 1 1.032 1 0.11 0 1001 1 -0.58 1 -0.581 3 -1.68 1 -0.582 1 0.11 1 0.110 0 100.00 0 1005 3 -0.07 3 -0.070 0 - 0 01 0 100.00 0 1001 0 100.00 0 1000 0 - 1 -1003 1 0.52 1 0.523 2 -0.18 2 -0.180 0 100.00 0 1003 2 -0.18 1 0.524 1 0.80 1 0.81 0 100.00 0 1001 0 100.00 4 -1.970 1 -100.00 1 -1000 1 -100.00 0 01 0 100.00 2 -1.280 3 -100.00 0 01 0 - 0 00 0 - 0 00 1 -100.00 1 -1000 0 - 0 01 0 - 0 08 2 0.80 2 0.81 0 - 0 00 1 -100.00 0 00 1 -100.00 0 00 1 -100.00 1 -1001 0 - 1 -0.581 0 - 1 -0.580 0 - 0 00 0 - 0 00 0 - 1 -1000 1 -100.00 0 01 0 - 0 01 1 -0.58 1 -0.580 1 -100.00 0 00 0 100.00 1 -1004 2 0.11 4 -0.582 1 0.11 0 1000 0 - 0 01 0 100.00 0 1001 0 100.00 0 1000 0 - 0 00 1 -100.00 0 00 0 - 1 -1000 0 100.00 0 1000 0 - 0 01 1 -0.58 2 -1.28

Sheet1

0 0 - 0 00 0 - 0 00 0 - 1 -100

10 11 -0.68 10 -0.582 2 -0.58 4 -1.280 0 - 0 00 1 -100.00 0 00 0 100.00 0 1000 0 - 0 07 3 0.27 3 0.260 0 - 1 -1001 1 -0.58 2 -1.281 1 -0.58 0 1000 0 - 0 00 0 100.00 0 1000 1 -100.00 3 -1000 0 - 0 00 0 - 0 00 1 -100.00 1 -1001 0 100.00 1 -0.580 0 - 0 00 0 - 0 01 0 100.00 0 1000 0 - 0 01 1 -0.58 0 1000 1 -100.00 1 -1001 0 100.00 0 1000 0 - 0 01 0 100.00 0 1001 1 -0.58 1 -0.581 1 -0.58 0 1001 0 100.00 1 -0.581 2 -1.28 2 -1.281 0 100.00 0 1000 1 -100.00 0 1001 0 100.00 1 -0.581 0 100.00 0 1001 0 100.00 1 -0.581 0 100.00 0 1000 1 -100.00 0 00 0 - 1 -1000 0 - 0 02 5 -1.50 2 -0.580 0 - 3 -1004 0 100.00 1 0.80 0 - 1 -1001 0 100.00 1 -0.580 0 - 2 -1001 0 100.00 1 -0.580 0 - 1 -1001 0 - 1 -0.582 0 100.00 1 0.111 0 100.00 0 1000 0 - 0 00 0 - 1 -1001 0 - 0 02 2 -0.58 1 0.11

Sheet1

0 0 100.00 0 1001 0 100.00 0 100

18 19 -0.64 15 -0.44 0 100.00 0 1001 0 - 0 00 0 - 0 00 1 -100.00 0 03 1 0.52 0 1002 0 100.00 1 0.110 1 -100.00 0 1000 1 -100.00 0 00 1 -100.00 1 -1000 0 - 1 -1000 0 - 1 -1000 1 -100.00 1 -1000 1 -100.00 0 02 1 0.11 0 1000 0 100.00 1 -1001 1 -0.58 1 -0.580 0 - 0 01 0 100.00 1 -0.580 2 -100.00 0 01 0 100.00 0 1006 0 100.00 2 0.521 3 -1.68 1 -0.581 1 -0.58 1 -0.580 0 - 0 00 1 -100.00 0 00 0 - 0 00 1 -100.00 0 01 1 -0.58 0 1001 0 100.00 1 -0.581 0 100.00 1 -0.580 0 - 0 00 0 100.00 0 1000 0 - 0 00 0 - 0 00 0 - 0 00 0 - 0 02 1 0.11 1 0.111 0 - 0 02 0 100.00 0 1001 0 100.00 0 1000 0 - 0 01 0 100.00 0 100

10 1 1.72 4 0.330 1 -100.00 1 -1001 0 100.00 2 -1.280 0 - 0 03 1 0.52 2 -0.183 1 0.52 1 0.520 1 -100.00 0 00 1 -100.00 2 -1000 1 -100.00 0 01 1 -0.58 0 1001 0 100.00 1 -0.580 1 -100.00 0 0

Sheet1

1 0 100.00 0 1000 0 100.00 0 1000 0 - 0 01 1 -0.58 1 -0.581 2 -1.28 0 1000 2 -100.00 0 00 0 - 0 04 1 0.80 0 1002 0 100.00 0 1001 0 100.00 0 1001 1 -0.58 0 1001 1 -0.58 0 00 0 - 0 01 1 -0.58 1 -0.580 0 - 0 00 2 -100.00 0 02 0 100.00 1 0.110 0 - 0 00 0 - 0 02 2 -0.58 2 -0.581 1 -0.58 0 00 0 - 0 02 0 100.00 1 0.111 0 100.00 1 -0.582 3 -0.99 1 0.115 6 -0.76 2 0.330 0 100.00 2 -1001 0 100.00 0 1002 1 0.11 1 0.110 2 -100.00 0 0

57 29 0.09 25 0.242 1 0.11 2 -0.581 1 -0.58 1 -0.58

33 35 -0.64 31 -0.521 2 -1.28 1 -0.582 2 -0.58 2 -0.582 1 0.11 2 -0.585 2 0.33 1 1.037 5 -0.25 7 -0.581 2 -1.28 2 -1.282 2 -0.58 2 -0.581 1 -0.58 2 -1.283 2 -0.18 2 -0.183 2 -0.18 1 0.522 1 0.11 2 -0.583 2 -0.18 1 0.526 4 -0.18 5 -0.40 0 - 0 01 2 -1.28 2 -1.282 2 -0.58 2 -0.581 0 100.00 1 -0.586 8 -0.87 6 -0.582 1 0.11 2 -0.582 1 0.11 2 -0.581 0 100.00 0 1001 2 -1.28 2 -1.281 1 -0.58 1 -0.58

Sheet1

2 2 -0.58 3 -0.990 2 -100.00 1 -1004 2 0.11 1 0.86 2 0.52 1 1.211 3 -1.68 1 -0.582 1 0.11 2 -0.586 5 -0.40 3 0.111 0 - 0 02 2 -0.58 1 0.118 6 -0.29 4 0.111 1 -0.58 2 -1.287 2 0.67 1 1.362 1 0.11 1 0.111 1 -0.58 1 -0.589 6 -0.18 2 0.920 1 -100.00 1 -1001 2 -1.28 1 -0.584 6 -0.99 4 -0.58

40 28 -0.23 28 -0.231 1 -0.58 0 1002 1 0.11 2 -0.581 0 100.00 2 -1.281 1 -0.58 1 -0.582 0 100.00 1 0.111 1 -0.58 1 -0.580 1 -100.00 0 00 0 - 0 02 3 -0.99 1 0.111 1 -0.58 1 -0.581 1 -0.58 2 -1.280 1 -100.00 1 -1001 4 -1.97 0 1000 1 -100.00 2 -1005 3 -0.07 3 -0.072 2 -0.58 3 -0.993 2 -0.18 2 -0.186 3 0.11 2 0.521 2 -1.28 1 -0.582 0 100.00 2 -0.580 1 -100.00 2 -1001 1 -0.58 1 -0.583 2 -0.18 4 -0.870 0 - 0 00 1 -100.00 1 -1001 1 -0.58 1 -0.583 2 -0.18 1 0.521 1 -0.58 1 -0.582 2 -0.58 1 0.110 0 - 0 02 0 100.00 1 0.112 2 -0.58 2 -0.586 4 -0.18 2 0.528 3 0.40 3 0.41 1 -0.58 0 1002 2 -0.58 0 1001 1 -0.58 1 -0.580 1 -100.00 0 0

Sheet1

2 3 -0.99 1 0.111 2 -1.28 2 -1.280 1 -100.00 1 -1001 0 100.00 1 -0.583 3 -0.58 0 1001 1 -0.58 1 -0.581 0 100.00 0 1005 8 -1.05 5 -0.580 0 - 0 00 1 -100.00 1 -1000 1 -100.00 1 -1001 1 -0.58 3 -1.682 0 100.00 0 1000 2 -100.00 0 02 3 -0.99 2 -0.580 1 -100.00 0 00 1 -100.00 0 00 1 -100.00 0 01 1 -0.58 0 1000 0 - 0 02 2 -0.58 0 1000 1 -100.00 0 01 1 -0.58 1 -0.582 1 0.11 0 1000 0 - 0 00 2 -100.00 1 -1002 0 100.00 1 0.110 0 - 0 00 0 - 0 02 3 -0.99 3 -0.990 0 - 2 -100

21 27 -0.84 25 -0.764 2 0.11 4 -0.580 0 100.00 0 1007 9 -0.83 4 -0.021 0 100.00 1 -0.580 1 -100.00 1 -1000 0 - 1 -1000 0 - 0 03 3 -0.58 1 0.521 0 100.00 0 1001 2 -1.28 0 00 0 100.00 1 -1001 1 -0.58 0 1003 1 0.52 0 1002 1 0.11 3 -0.991 2 -1.28 2 -1.280 0 - 0 00 0 - 0 04 0 100.00 0 1000 1 -100.00 1 -1003 0 100.00 0 1000 0 - 1 -1001 1 -0.58 0 1000 0 - 0 00 1 -100.00 0 00 1 -100.00 1 -100

Sheet1

3 3 -0.58 3 -0.581 1 -0.58 0 1000 1 -100.00 0 1002 1 0.11 1 0.110 0 - 1 -1001 0 100.00 0 1000 0 - 0 00 0 - 0 00 0 - 0 00 0 - 0 01 4 -1.97 3 -1.681 0 100.00 0 1001 0 100.00 0 1001 0 100.00 1 -0.581 0 100.00 0 1001 0 - 1 -0.580 0 - 0 00 1 -100.00 0 00 0 - 0 00 0 - 1 -1001 2 -1.28 1 -0.580 0 - 0 01 0 100.00 1 -0.582 6 -1.68 3 -0.991 0 100.00 0 1000 0 - 0 01 0 - 1 -0.580 0 - 0 00 0 - 0 00 1 -100.00 1 -1003 2 -0.18 0 1000 0 100.00 0 1001 0 100.00 0 1000 0 - 1 -1000 0 - 0 01 3 -1.68 0 00 0 - 0 00 0 100.00 0 1000 0 - 0 02 1 0.11 2 -0.580 0 - 0 03 1 0.52 2 -0.180 0 - 1 -1001 0 - 0 00 0 - 2 -1000 0 100.00 0 1000 0 - 0 01 0 100.00 1 -0.580 1 -100.00 1 -1002 1 0.11 0 1000 1 -100.00 0 01 0 100.00 0 1001 3 -1.68 1 -0.582 0 100.00 1 0.110 0 - 0 01 0 100.00 0 1008 6 -0.29 7 -0.45

Sheet1

0 0 - 0 03 7 -1.43 3 -0.581 0 100.00 0 100

16 11 -0.21 4 0.80 0 - 0 01 1 -0.58 1 -0.582 3 -0.99 1 0.110 0 100.00 0 1000 0 - 0 00 0 - 1 -1000 0 - 0 06 9 -0.99 4 -0.181 0 100.00 3 -1.681 3 -1.68 1 -0.580 0 - 1 -1000 0 100.00 1 -1000 0 100.00 0 1000 0 - 0 03 1 0.52 0 1000 0 - 0 00 0 - 1 -1001 0 100.00 0 1000 1 -100.00 0 00 0 - 2 -1000 0 - 1 -1000 0 - 0 01 0 100.00 1 -0.581 1 -0.58 1 -0.586 5 -0.40 2 0.520 0 - 1 -1001 1 -0.58 1 -0.580 0 100.00 0 1000 0 - 0 04 4 -0.58 4 -0.580 1 -100.00 0 00 0 - 0 00 0 - 0 01 3 -1.68 1 -0.580 1 -100.00 0 01 0 100.00 1 -0.580 0 - 0 01 0 - 0 02 1 0.11 2 -0.581 1 -0.58 1 -0.581 1 -0.58 2 -1.281 1 -0.58 1 -0.581 1 -0.58 1 -0.581 1 -0.58 0 1001 0 100.00 0 1001 1 -0.58 0 00 0 - 0 00 2 -100.00 2 -1000 0 - 1 -100

17 13 -0.31 15 -0.460 0 - 0 00 0 - 0 00 2 -100.00 0 0

Sheet1

0 0 - 0 01 0 100.00 0 1000 0 - 1 -1000 0 100.00 0 1005 3 -0.07 2 0.330 0 - 1 -1000 1 -100.00 1 -1001 0 - 0 02 2 -0.58 1 0.112 0 - 0 01 1 -0.58 0 00 0 - 1 -1001 2 -1.28 1 -0.581 0 100.00 0 1008 6 -0.29 8 -0.580 0 - 0 01 1 -0.58 0 1003 1 0.52 3 -0.585 2 0.33 0 1000 1 -100.00 1 -100

12 8 -0.18 3 0.81 0 100.00 2 -1.280 1 -100.00 0 00 1 -100.00 0 02 1 0.11 1 0.111 0 100.00 0 1001 1 -0.58 1 -0.580 1 -100.00 0 00 0 - 0 00 1 -100.00 0 00 0 - 0 04 1 0.80 0 1001 1 -0.58 0 1000 0 - 0 00 1 -100.00 0 00 0 100.00 1 -1001 1 -0.58 2 -1.281 0 100.00 0 1000 0 - 1 -1003 2 -0.18 3 -0.581 0 100.00 0 1000 1 -100.00 0 00 0 - 0 02 1 0.11 1 0.110 0 - 1 -1001 0 100.00 0 1001 0 100.00 1 -0.580 0 - 0 01 1 -0.58 1 -0.585 3 -0.07 1 1.030 0 - 0 00 0 - 0 01 1 -0.58 0 1001 1 -0.58 0 00 0 - 0 00 0 - 1 -1000 1 -100.00 1 -100

Sheet1

0 1 -100.00 1 -1001 0 100.00 1 -0.580 0 - 0 00 0 - 0 01 2 -1.28 0 1002 0 100.00 1 0.110 0 - 2 -1003 4 -0.87 3 -0.580 0 - 1 -1000 1 -100.00 0 00 1 -100.00 0 01 1 -0.58 0 01 0 100.00 0 1006 7 -0.74 2 0.521 2 -1.28 2 -1.281 1 -0.58 1 -0.581 0 100.00 1 -0.580 1 -100.00 1 -1001 2 -1.28 1 -0.587 6 -0.43 7 -0.583 0 100.00 1 0.521 1 -0.58 0 1001 1 -0.58 1 -0.584 2 0.11 1 0.83 3 -0.58 5 -1.092 3 -0.99 5 -1.50 0 - 0 01 1 -0.58 1 -0.581 1 -0.58 0 01 0 100.00 0 1000 1 -100.00 1 -1002 1 0.11 0 1002 1 0.11 2 -0.580 2 -100.00 1 -1004 2 0.11 3 -0.293 3 -0.58 2 -0.181 1 -0.58 2 -1.281 0 100.00 0 1001 1 -0.58 1 -0.582 1 0.11 2 -0.582 2 -0.58 0 1009 4 0.23 2 0.921 1 -0.58 1 -0.582 3 -0.99 2 -0.581 2 -1.28 0 1001 0 - 0 03 3 -0.58 2 -0.181 2 -1.28 1 -0.580 1 -100.00 0 01 2 -1.28 1 -0.581 2 -1.28 1 -0.581 1 -0.58 1 -0.586 2 0.52 1 1.211 1 -0.58 1 -0.582 1 0.11 1 0.111 1 -0.58 2 -1.283 1 0.52 2 -0.18

Sheet1

1 1 -0.58 1 -0.582 3 -0.99 1 0.113 1 0.52 1 0.521 0 - 1 -0.583 2 -0.18 3 -0.582 1 0.11 1 0.112 2 -0.58 3 -0.991 1 -0.58 2 -1.284 3 -0.29 2 0.112 1 0.11 2 -0.585 5 -0.58 2 0.331 1 -0.58 2 -1.282 3 -0.99 1 0.110 1 -100.00 1 -1002 2 -0.58 1 0.116 9 -0.99 6 -0.581 1 -0.58 1 -0.581 1 -0.58 0 1002 3 -0.99 1 0.111 1 -0.58 0 1005 2 0.33 3 -0.071 1 -0.58 1 -0.581 3 -1.68 2 -1.281 1 -0.58 1 -0.582 1 0.11 1 0.112 2 -0.58 1 0.115 3 -0.07 4 -0.363 7 -1.43 4 -0.871 1 -0.58 1 -0.581 1 -0.58 1 -0.582 1 0.11 1 0.11

16 10 -0.11 19 -0.762 1 0.11 1 0.111 3 -1.68 1 -0.581 1 -0.58 1 -0.58

11 5 0.21 3 0.726 4 -0.18 7 -0.743 3 -0.58 1 0.524 0 100.00 3 -0.293 1 0.52 1 0.521 2 -1.28 2 -1.282 2 -0.58 1 0.117 2 0.67 2 0.675 5 -0.58 6 -0.77

18 18 -0.58 18 -0.581 1 -0.58 2 -1.281 1 -0.58 1 -0.581 1 -0.58 1 -0.581 1 -0.58 3 -1.681 1 -0.58 2 -1.280 1 -100.00 1 -1001 1 -0.58 2 -1.282 1 0.11 1 0.111 1 -0.58 1 -0.581 1 -0.58 1 -0.581 2 -1.28 1 -0.582 2 -0.58 1 0.11

Sheet1

4 2 0.11 2 0.113 2 -0.18 1 0.521 1 -0.58 1 -0.581 3 -1.68 1 -0.581 1 -0.58 2 -1.282 2 -0.58 1 0.111 1 -0.58 2 -1.289 4 0.23 8 -0.473 2 -0.18 3 -0.585 5 -0.58 4 -0.361 1 -0.58 1 -0.581 1 -0.58 3 -1.683 2 -0.18 1 0.521 2 -1.28 2 -1.281 1 -0.58 1 -0.581 1 -0.58 1 -0.584 1 0.80 1 0.82 1 0.11 1 0.115 4 -0.36 6 -0.774 2 0.11 3 -0.29

15 7 0.18 7 0.184 5 -0.81 3 -0.293 4 -0.87 2 -0.180 1 -100.00 2 -1003 2 -0.18 2 -0.181 2 -1.28 2 -1.282 1 0.11 1 0.111 2 -1.28 3 -1.680 0 - 1 -1004 4 -0.58 1 0.80 0 - 0 01 2 -1.28 1 -0.582 1 0.11 1 0.111 1 -0.58 1 -0.58

13 12 -0.50 12 -0.50 0 100.00 0 1003 2 -0.18 3 -0.585 5 -0.58 5 -0.581 3 -1.68 0 1003 1 0.52 2 -0.181 1 -0.58 0 1000 0 - 2 -1001 1 -0.58 1 -0.580 1 -100.00 1 -1005 3 -0.07 6 -0.770 0 - 0 00 1 -100.00 0 01 2 -1.28 2 -1.280 0 - 1 -1004 2 0.11 5 -0.813 0 100.00 2 -0.181 0 100.00 0 1000 1 -100.00 0 0

43 40 -0.51 35 -0.381 0 100.00 1 -0.58

11 7 -0.13 5 0.2119 15 -0.35 15 -0.35

Sheet1

2 0 100.00 0 1000 0 - 0 00 0 - 0 0

34 34 -0.58 26 -0.311 1 -0.58 0 1000 1 -100.00 0 01 0 - 1 -0.580 0 - 0 00 0 - 0 00 0 - 0 02 0 100.00 1 0.111 0 100.00 2 -1.280 0 100.00 1 -1004 2 0.11 4 -0.583 2 -0.18 1 0.522 1 0.11 1 0.111 1 -0.58 2 -1.281 1 -0.58 1 -0.580 0 - 0 01 1 -0.58 1 -0.582 1 0.11 1 0.114 1 0.80 1 0.82 1 0.11 2 -0.583 3 -0.58 4 -0.870 1 -100.00 1 -1001 1 -0.58 2 -1.282 1 0.11 1 0.111 1 -0.58 1 -0.58

10 6 -0.07 4 0.330 0 - 0 02 0 100.00 0 1001 1 -0.58 0 1000 0 - 1 -1000 0 100.00 0 1004 3 -0.29 4 -0.589 4 0.23 6 -0.181 0 100.00 3 -1.681 0 100.00 1 -0.581 1 -0.58 0 03 1 0.52 1 0.520 1 -100.00 0 1004 3 -0.29 2 0.110 0 - 0 02 0 100.00 0 1001 1 -0.58 1 -0.580 0 - 0 01 0 100.00 0 1001 1 -0.58 1 -0.581 1 -0.58 0 1002 0 - 0 00 0 - 0 02 0 100.00 1 0.110 1 -100.00 0 03 1 0.52 0 1003 1 0.52 2 -0.189 10 -0.69 13 -0.954 4 -0.58 5 -0.81

Sheet1

2 1 0.11 1 0.110 1 -100.00 0 01 1 -0.58 1 -0.581 1 -0.58 2 -1.283 0 100.00 0 1001 0 - 1 -0.581 0 100.00 0 1003 3 -0.58 4 -0.872 2 -0.58 1 0.111 1 -0.58 2 -1.281 2 -1.28 1 -0.581 3 -1.68 1 -0.582 2 -0.58 2 -0.584 4 -0.58 3 -0.290 1 -100.00 0 03 1 0.52 1 0.524 4 -0.58 11 -1.61 2 -1.28 0 1002 1 0.11 1 0.110 0 - 0 03 6 -1.28 5 -1.090 0 - 1 -1004 1 0.80 0 1001 1 -0.58 0 1002 0 100.00 0 1000 0 - 1 -1002 2 -0.58 1 0.110 0 - 0 00 0 - 0 01 1 -0.58 2 -1.281 1 -0.58 1 -0.583 2 -0.18 2 -0.180 1 -100.00 0 00 0 - 0 00 2 -100.00 1 -1000 0 100.00 1 -1002 1 0.11 0 1000 1 -100.00 0 01 0 100.00 1 -0.581 1 -0.58 0 1001 1 -0.58 1 -0.580 3 -100.00 3 -1001 0 100.00 0 100

15 8 0.05 7 0.182 2 -0.58 2 -0.580 0 - 1 -1001 0 100.00 0 1000 0 - 0 01 1 -0.58 0 1002 3 -0.99 3 -0.993 3 -0.58 3 -0.584 4 -0.58 3 -0.291 1 -0.58 1 -0.581 1 -0.58 2 -1.282 1 0.11 3 -0.990 1 -100.00 0 00 0 - 0 0

Sheet1

3 0 100.00 2 -0.180 0 - 0 00 1 -100.00 0 00 0 100.00 0 1002 0 100.00 0 1003 1 0.52 1 0.522 0 100.00 0 1000 2 -100.00 4 -1002 0 100.00 0 100

12 8 -0.18 6 0.112 3 -0.99 1 0.115 5 -0.58 6 -0.770 0 - 0 01 1 -0.58 0 1001 0 100.00 1 -0.581 0 - 1 -0.581 1 -0.58 0 1002 3 -0.99 2 -0.582 0 100.00 0 1001 1 -0.58 1 -0.581 0 100.00 1 -0.580 0 - 1 -1003 1 0.52 1 0.520 0 - 0 05 2 0.33 1 1.031 1 -0.58 1 -0.582 0 100.00 0 1001 0 100.00 0 1002 2 -0.58 1 0.114 3 -0.29 2 0.110 2 -100.00 1 -1009 9 -0.58 6 -0.181 0 - 0 0

18 11 -0.09 17 -0.532 2 -0.58 1 0.112 0 100.00 1 0.118 3 0.40 3 0.41 1 -0.58 1 -0.581 0 - 0 02 4 -1.28 1 0.110 1 -100.00 1 -100

10 8 -0.36 10 -0.583 1 0.52 1 0.521 2 -1.28 3 -1.681 1 -0.58 1 -0.583 3 -0.58 4 -0.871 0 - 1 -0.582 1 0.11 1 0.119 12 -0.87 10 -0.694 2 0.11 3 -0.291 2 -1.28 1 -0.582 1 0.11 2 -0.580 2 -100.00 2 -1000 0 - 0 06 2 0.52 1 1.211 1 -0.58 1 -0.582 1 0.11 2 -0.58

Sheet1

2 2 -0.58 2 -0.580 0 - 0 02 2 -0.58 3 -0.990 1 -100.00 1 -1000 0 - 0 00 1 -100.00 1 -1002 1 0.11 1 0.114 1 0.80 1 0.82 3 -0.99 2 -0.583 3 -0.58 3 -0.580 0 - 0 01 1 -0.58 0 1001 0 100.00 1 -0.58

48 7 1.35 10 0.991 0 - 0 00 0 - 0 01 1 -0.58 0 1003 1 0.52 5 -1.092 5 -1.50 0 1001 0 - 2 -1.287 6 -0.43 5 -0.251 1 -0.58 2 -1.281 1 -0.58 2 -1.281 1 -0.58 1 -0.581 1 -0.58 0 00 0 - 0 00 1 -100.00 0 00 0 - 0 02 2 -0.58 2 -0.583 3 -0.58 3 -0.587 7 -0.58 4 -0.020 1 -100.00 1 -1003 4 -0.87 1 0.520 1 -100.00 1 -1004 8 -1.28 1 0.88 7 -0.45 5 -0.110 0 - 1 -1000 0 100.00 0 1000 0 - 0 01 0 100.00 0 100

11 6 0.02 10 -0.493 4 -0.87 3 -0.585 4 -0.36 5 -0.584 3 -0.29 3 -0.294 1 0.80 1 0.81 2 -1.28 0 0

20 35 -1.14 24 -0.770 0 - 0 02 2 -0.58 4 -1.282 1 0.11 1 0.111 1 -0.58 1 -0.581 1 -0.58 0 02 1 0.11 0 1000 1 -100.00 0 09 5 0.01 8 -0.47

13 15 -0.73 12 -0.51 1 -0.58 2 -1.28

Sheet1

0 0 100.00 0 1001 5 -2.19 3 -1.681 0 100.00 1 -0.583 4 -0.87 3 -0.580 0 - 0 00 0 100.00 0 100

17 14 -0.39 14 -0.390 1 -100.00 1 -1001 1 -0.58 1 -0.580 0 - 1 -1000 1 -100.00 0 00 0 - 0 00 0 - 2 -1000 0 - 1 -1000 0 - 0 01 0 100.00 0 1002 2 -0.58 1 0.112 0 - 0 00 2 -100.00 0 00 0 - 1 -1000 0 - 0 01 1 -0.58 1 -0.581 0 100.00 0 1001 1 -0.58 1 -0.581 2 -1.28 0 02 1 0.11 4 -1.280 0 - 0 00 1 -100.00 1 -1000 0 - 2 -1004 6 -0.99 7 -1.140 1 -100.00 0 00 1 -100.00 0 01 0 - 1 -0.580 0 - 0 01 2 -1.28 0 1000 1 -100.00 0 01 0 100.00 0 1000 0 - 0 00 1 -100.00 0 00 1 -100.00 1 -1000 1 -100.00 0 00 1 -100.00 0 1002 1 0.11 1 0.111 2 -1.28 2 -1.28

25 44 -1.15 38 -12 0 100.00 2 -0.585 2 0.33 0 1000 0 100.00 0 1000 0 - 1 -1001 1 -0.58 2 -1.281 1 -0.58 0 1001 1 -0.58 1 -0.580 0 - 0 00 0 - 0 01 0 100.00 0 1000 0 - 0 00 0 - 0 0

Sheet1

0 1 -100.00 1 -1000 0 - 0 00 0 - 1 -1002 0 100.00 1 0.110 0 - 0 00 0 - 0 01 0 100.00 0 1000 0 - 0 00 1 -100.00 1 -1002 0 100.00 1 0.110 1 -100.00 0 02 1 0.11 0 1000 0 - 0 00 0 100.00 0 1000 0 - 0 00 0 100.00 1 -1000 0 - 0 00 0 - 0 0

16 14 -0.45 16 -0.580 1 -100.00 0 00 0 - 0 00 1 -100.00 0 01 1 -0.58 0 00 0 - 2 -1001 0 100.00 0 1000 0 - 0 00 0 - 0 02 2 -0.58 1 0.114 5 -0.81 3 -0.291 0 100.00 0 1001 0 - 2 -1.280 1 -100.00 0 01 0 100.00 1 -0.580 0 - 0 02 0 100.00 0 1001 0 100.00 0 1000 0 - 0 00 1 -100.00 0 00 0 - 0 00 0 - 0 02 1 0.11 0 1000 0 - 0 00 0 - 0 01 0 - 0 00 0 - 1 -1002 0 100.00 0 1000 0 - 0 00 2 -100.00 0 00 0 - 0 01 1 -0.58 1 -0.580 0 100.00 1 -1000 0 - 1 -1000 1 -100.00 0 00 1 -100.00 1 -1000 0 100.00 0 1000 0 - 0 00 0 - 1 -100

Sheet1

0 0 - 1 -1000 0 - 0 00 1 -100.00 0 00 0 - 0 00 0 100.00 0 1000 1 -100.00 0 03 2 -0.18 1 0.522 2 -0.58 3 -0.991 0 100.00 0 1001 0 100.00 0 1000 1 -100.00 0 01 0 100.00 0 1001 0 100.00 0 1001 0 100.00 1 -0.581 0 - 0 01 1 -0.58 0 1001 0 100.00 0 1001 0 100.00 1 -0.582 2 -0.58 3 -0.990 0 - 1 -1006 8 -0.87 3 0.110 1 -100.00 0 00 1 -100.00 0 00 0 - 0 00 1 -100.00 1 -1000 0 100.00 0 1000 0 100.00 1 -1000 1 -100.00 0 1001 1 -0.58 1 -0.580 0 - 1 -1000 0 - 0 00 2 -100.00 0 00 1 -100.00 0 00 0 - 3 -1000 0 100.00 1 -1000 0 100.00 0 1000 1 -100.00 0 00 0 100.00 0 1000 0 - 0 04 2 0.11 4 -0.580 0 - 0 02 0 - 0 00 0 - 0 00 0 100.00 0 1000 0 - 0 01 0 100.00 0 1000 1 -100.00 1 -1000 2 -100.00 0 1000 2 -100.00 0 00 0 - 1 -1000 0 - 0 00 0 - 0 01 2 -1.28 1 -0.581 0 100.00 0 1001 0 - 1 -0.581 0 100.00 0 1001 3 -1.68 2 -1.28

Sheet1

0 0 - 1 -1000 0 - 0 01 1 -0.58 0 1002 2 -0.58 0 1000 0 - 0 00 0 - 0 01 0 100.00 0 1000 1 -100.00 0 1000 0 - 0 00 0 - 0 00 1 -100.00 0 02 1 0.11 0 02 1 0.11 0 1001 0 100.00 0 1001 2 -1.28 0 1000 0 - 1 -1000 1 -100.00 2 -1000 0 - 1 -1001 1 -0.58 3 -1.680 0 - 1 -1001 0 100.00 1 -0.580 1 -100.00 1 -1000 0 - 0 00 0 - 1 -1000 0 - 1 -1000 1 -100.00 0 00 0 - 1 -1002 0 100.00 0 1001 1 -0.58 0 1001 0 100.00 1 -0.580 0 - 0 00 1 -100.00 1 -1000 1 -100.00 1 -1000 0 100.00 0 1003 2 -0.18 1 0.523 1 0.52 2 -0.180 0 - 0 00 0 - 0 02 0 100.00 0 1000 0 - 1 -1001 0 100.00 0 1000 0 - 0 00 0 100.00 0 1002 1 0.11 2 -0.581 0 100.00 0 1002 0 100.00 0 1002 0 100.00 0 1000 1 -100.00 3 -1000 2 -100.00 1 -1000 0 - 0 01 0 100.00 0 1000 1 -100.00 0 00 2 -100.00 0 00 0 - 1 -1000 1 -100.00 0 00 1 -100.00 0 02 1 0.11 1 0.11

Sheet1

1 1 -0.58 1 -0.584 0 100.00 0 1000 0 - 0 02 0 100.00 0 1001 0 - 0 00 0 100.00 0 1000 0 - 0 00 0 - 1 -1000 0 - 0 00 1 -100.00 1 -1000 1 -100.00 0 01 1 -0.58 0 00 0 - 0 00 0 - 0 03 0 100.00 0 1002 1 0.11 0 1000 0 - 0 00 0 - 0 00 0 - 0 01 0 100.00 1 -0.581 1 -0.58 0 1000 1 -100.00 0 00 0 - 1 -1001 0 100.00 0 1001 1 -0.58 1 -0.580 0 100.00 1 -1000 0 - 0 02 1 0.11 1 0.110 0 - 0 00 0 - 0 01 0 100.00 0 1000 0 - 1 -1000 2 -100.00 0 01 0 - 0 00 0 - 0 00 0 - 2 -1001 2 -1.28 3 -1.682 0 100.00 0 1001 0 100.00 1 -0.581 0 100.00 1 -0.580 0 100.00 0 1008 2 0.80 0 1002 1 0.11 0 1001 0 100.00 0 1000 0 - 0 00 0 - 1 -1001 0 100.00 1 -0.580 0 - 0 00 0 100.00 0 1002 2 -0.58 0 01 1 -0.58 0 1000 0 100.00 0 1000 0 - 0 01 0 100.00 0 1000 0 - 0 02 1 0.11 0 1000 2 -100.00 0 0

Sheet1

0 0 - 2 -1000 0 - 0 00 0 100.00 1 -1000 0 - 0 00 0 - 1 -1000 1 -100.00 0 00 0 - 0 04 4 -0.58 3 -0.290 0 - 0 00 2 -100.00 1 -1000 0 100.00 0 1001 1 -0.58 0 1002 1 0.11 2 -0.580 0 - 1 -1001 1 -0.58 0 1001 0 100.00 1 -0.580 0 - 1 -1001 1 -0.58 1 -0.580 0 - 0 00 0 - 0 00 0 100.00 2 -1001 0 - 2 -1.280 0 - 0 00 2 -100.00 0 01 0 100.00 2 -1.283 3 -0.58 14 -2.120 1 -100.00 1 -1001 0 - 0 00 0 - 0 00 1 -100.00 0 1003 2 -0.18 2 -0.180 0 - 0 00 0 - 1 -1004 4 -0.58 1 0.82 3 -0.99 1 0.110 0 - 0 02 1 0.11 0 1003 0 100.00 1 0.520 1 -100.00 1 -1000 0 - 1 -1000 0 - 0 00 1 -100.00 0 00 0 - 0 02 0 100.00 4 -1.282 0 100.00 1 0.110 0 100.00 0 1000 0 100.00 0 1000 1 -100.00 0 01 0 100.00 0 1001 0 - 2 -1.281 1 -0.58 1 -0.580 0 - 0 00 0 - 0 00 0 - 0 00 1 -100.00 0 1000 0 100.00 0 1000 0 - 0 0

Sheet1

1 0 100.00 0 1001 0 100.00 0 1006 6 -0.58 5 -0.43 5 -1.09 3 -0.581 0 100.00 0 1000 0 - 1 -1001 0 100.00 0 1000 0 - 0 01 0 - 1 -0.583 1 0.52 3 -0.580 1 -100.00 0 1001 1 -0.58 1 -0.585 1 1.03 3 -0.072 1 0.11 3 -0.990 1 -100.00 1 -1001 0 - 0 01 0 100.00 0 1000 0 100.00 1 -1000 0 - 0 02 1 0.11 1 0.111 1 -0.58 1 -0.581 2 -1.28 1 -0.581 0 100.00 1 -0.581 0 100.00 0 1001 0 - 1 -0.580 0 - 0 01 1 -0.58 3 -1.681 0 - 0 02 0 - 1 0.112 2 -0.58 0 1000 0 - 1 -1000 1 -100.00 0 00 0 - 0 02 2 -0.58 2 -0.582 0 100.00 1 0.111 0 100.00 0 1001 0 - 1 -0.580 0 - 0 01 0 - 2 -1.280 1 -100.00 0 00 0 - 0 01 1 -0.58 1 -0.580 0 - 1 -1001 0 100.00 0 1001 0 100.00 1 -0.580 0 - 1 -1001 0 100.00 0 1000 0 - 1 -1002 0 100.00 1 0.111 1 -0.58 0 00 0 - 0 01 0 100.00 0 1000 0 - 1 -1000 0 - 0 02 2 -0.58 3 -0.992 2 -0.58 2 -0.581 1 -0.58 0 100

Sheet1

0 0 - 0 01 0 100.00 1 -0.581 1 -0.58 1 -0.581 0 100.00 2 -1.280 0 - 1 -1000 0 - 0 01 0 100.00 1 -0.580 0 - 0 01 1 -0.58 0 1000 0 - 0 00 0 - 1 -1002 3 -0.99 3 -0.990 0 - 2 -1001 0 100.00 0 1004 6 -0.99 5 -0.811 0 - 2 -1.280 1 -100.00 0 05 1 1.03 0 1000 1 -100.00 0 00 3 -100.00 3 -1002 3 -0.99 1 0.110 0 - 1 -1000 2 -100.00 3 -1001 0 100.00 0 1002 1 0.11 2 -0.580 0 - 0 09 7 -0.33 3 0.521 0 100.00 0 1000 0 - 1 -1001 1 -0.58 1 -0.581 0 100.00 0 1002 2 -0.58 1 0.115 5 -0.58 4 -0.360 0 100.00 2 -1001 2 -1.28 2 -1.280 3 -100.00 1 -1000 0 - 1 -1000 0 - 1 -1002 0 100.00 0 1001 0 100.00 0 1001 0 100.00 0 1000 0 - 0 01 0 100.00 1 -0.582 1 0.11 0 1001 1 -0.58 4 -1.970 1 -100.00 2 -1001 0 - 0 00 2 -100.00 0 00 1 -100.00 1 -1001 1 -0.58 2 -1.283 1 0.52 1 0.521 0 - 2 -1.287 2 0.67 3 0.260 0 100.00 0 1000 0 - 1 -1000 0 - 0 01 0 100.00 0 100

Sheet1

0 0 - 1 -1003 2 -0.18 2 -0.180 1 -100.00 0 00 0 - 2 -1000 0 - 0 00 0 - 0 00 1 -100.00 1 -1000 0 - 0 01 1 -0.58 2 -1.281 0 100.00 0 1002 2 -0.58 3 -0.991 2 -1.28 2 -1.280 0 - 0 04 0 100.00 1 0.85 1 1.03 4 -0.362 1 0.11 1 0.115 5 -0.58 2 0.331 0 - 0 00 0 - 0 00 0 - 0 00 0 - 1 -1000 0 - 0 01 0 100.00 0 1000 0 - 0 00 0 - 1 -1001 0 100.00 0 1000 0 - 0 00 1 -100.00 3 -1000 0 - 0 01 0 100.00 0 1002 2 -0.58 1 0.113 5 -1.09 4 -0.870 0 - 0 01 0 100.00 0 1001 1 -0.58 1 -0.580 0 - 2 -1000 0 - 1 -1000 0 100.00 0 1000 2 -100.00 1 -1000 0 - 0 00 0 - 0 01 1 -0.58 2 -1.280 0 - 0 00 1 -100.00 0 00 0 - 1 -1000 3 -100.00 3 -1000 0 100.00 0 1000 0 - 0 00 0 - 2 -1000 0 - 0 03 1 0.52 0 1002 0 100.00 1 0.111 1 -0.58 3 -1.680 1 -100.00 0 01 0 100.00 0 1001 0 100.00 0 1003 1 0.52 1 0.52

Sheet1

1 2 -1.28 0 1000 0 - 0 02 1 0.11 1 0.116 2 0.52 1 1.210 2 -100.00 1 -1000 0 - 1 -1000 0 - 0 00 0 - 1 -1002 1 0.11 4 -1.281 0 100.00 0 1000 0 - 0 01 0 100.00 0 1001 0 100.00 0 1000 0 - 0 00 2 -100.00 0 1001 1 -0.58 2 -1.281 0 100.00 0 1002 0 100.00 0 1000 0 - 0 01 3 -1.68 1 -0.580 2 -100.00 0 01 0 - 2 -1.280 1 -100.00 1 -1000 0 - 0 02 0 100.00 0 1002 4 -1.28 2 -0.581 0 100.00 1 -0.580 1 -100.00 1 -1000 0 - 1 -1000 0 - 1 -1001 0 - 1 -0.580 0 - 0 02 0 100.00 0 1000 1 -100.00 0 00 0 - 0 00 0 - 2 -1000 0 - 0 01 0 100.00 0 1000 1 -100.00 0 00 1 -100.00 1 -1000 0 - 0 05 0 100.00 1 1.032 0 - 0 00 0 100.00 2 -1001 0 100.00 0 1003 2 -0.18 3 -0.580 0 - 0 03 7 -1.43 6 -1.281 4 -1.97 1 -0.580 0 - 1 -1000 0 - 0 00 1 -100.00 0 00 1 -100.00 0 00 0 - 0 00 0 - 0 02 2 -0.58 1 0.112 1 0.11 2 -0.58

Sheet1

1 1 -0.58 0 1001 2 -1.28 0 1000 0 100.00 0 1002 0 100.00 0 1000 0 - 0 02 0 100.00 0 1000 1 -100.00 0 00 0 - 0 01 1 -0.58 1 -0.582 0 100.00 1 0.111 0 - 0 02 2 -0.58 2 -0.581 1 -0.58 0 1000 1 -100.00 0 00 1 -100.00 0 1000 0 - 0 02 1 0.11 0 1000 0 - 0 00 1 -100.00 0 00 1 -100.00 2 -1001 1 -0.58 0 1000 0 - 1 -1001 1 -0.58 1 -0.581 1 -0.58 1 -0.582 1 0.11 1 0.110 1 -100.00 1 -1000 0 - 0 01 1 -0.58 0 00 0 - 0 01 0 100.00 0 1000 0 - 0 00 0 - 1 -1004 0 100.00 1 0.81 0 - 1 -0.580 1 -100.00 0 01 0 100.00 0 1000 0 100.00 0 1002 0 100.00 0 1000 0 - 0 00 1 -100.00 2 -1001 1 -0.58 3 -1.681 0 - 0 02 0 100.00 0 1000 0 - 0 01 0 100.00 1 -0.580 0 - 0 00 0 - 0 00 1 -100.00 2 -1000 0 - 0 01 0 100.00 0 1001 0 100.00 1 -0.581 1 -0.58 0 00 0 - 1 -1000 0 - 1 -1001 0 100.00 0 1002 1 0.11 1 0.111 0 100.00 0 100

Sheet1

2 1 0.11 1 0.1116 16 -0.58 10 -0.110 0 - 0 03 2 -0.18 1 0.520 0 - 0 00 0 - 0 03 7 -1.43 8 -1.560 0 - 1 -1000 0 - 0 02 1 0.11 0 01 0 100.00 0 1001 1 -0.58 0 1000 0 - 0 01 1 -0.58 0 1001 0 100.00 0 1001 0 100.00 0 1000 0 - 0 00 0 - 0 05 4 -0.36 5 -0.581 0 100.00 1 -0.580 0 - 0 01 0 100.00 1 -0.580 0 - 0 02 0 100.00 1 0.110 0 100.00 0 1005 5 -0.58 3 -0.072 1 0.11 0 02 0 100.00 0 1000 3 -100.00 1 -1002 1 0.11 0 1000 0 - 0 01 0 100.00 1 -0.581 0 100.00 0 1000 0 - 0 00 0 - 0 01 1 -0.58 1 -0.581 1 -0.58 0 1001 1 -0.58 1 -0.581 0 100.00 0 1000 0 - 0 01 1 -0.58 0 1001 0 100.00 0 1000 1 -100.00 1 -1001 1 -0.58 2 -1.281 0 - 0 01 0 100.00 0 1000 0 - 0 01 0 100.00 0 1001 2 -1.28 3 -1.680 0 - 0 00 0 - 0 01 1 -0.58 0 1001 0 100.00 0 1000 0 - 0 01 4 -1.97 3 -1.680 0 - 1 -1001 1 -0.58 2 -1.28

Sheet1

0 0 - 0 04 2 0.11 4 -0.581 0 100.00 0 1000 0 - 0 00 1 -100.00 1 -1001 0 100.00 0 1000 0 - 0 01 0 100.00 0 1002 0 100.00 0 1003 0 100.00 0 1000 0 - 0 0

25 20 -0.36 14 00 0 - 0 00 0 - 1 -1001 1 -0.58 2 -1.280 0 - 0 00 0 100.00 0 1001 1 -0.58 0 02 1 0.11 1 0.111 1 -0.58 1 -0.58

13 16 -0.79 15 -0.731 0 100.00 1 -0.582 2 -0.58 4 -1.280 0 - 0 03 1 0.52 2 -0.181 0 100.00 0 1001 1 -0.58 1 -0.580 1 -100.00 0 01 1 -0.58 0 00 0 - 0 02 0 100.00 0 1000 1 -100.00 1 -1000 0 100.00 0 1000 0 - 1 -1001 1 -0.58 1 -0.580 1 -100.00 0 01 1 -0.58 0 1001 0 100.00 2 -1.28

11 7 -0.13 5 0.211 2 -1.28 1 -0.581 0 100.00 0 1001 0 100.00 2 -1.281 2 -1.28 1 -0.583 2 -0.18 2 -0.180 0 - 0 02 1 0.11 1 0.110 0 100.00 0 1001 1 -0.58 1 -0.584 5 -0.81 4 -0.580 0 - 0 05 13 -1.54 13 -1.540 0 - 1 -1000 1 -100.00 0 01 1 -0.58 0 1002 0 100.00 0 1001 0 100.00 0 1001 0 100.00 0 100

Sheet1

0 0 - 0 04 3 -0.29 2 0.110 0 - 0 00 0 - 0 02 0 100.00 0 1000 0 - 0 00 0 - 0 00 0 - 0 02 2 -0.58 1 0.110 0 100.00 0 1001 0 100.00 0 1001 1 -0.58 1 -0.580 1 -100.00 1 -1001 0 100.00 1 -0.581 0 100.00 0 1002 1 0.11 1 0.110 1 -100.00 0 02 2 -0.58 2 -0.580 1 -100.00 1 -1000 0 - 0 00 0 - 1 -1002 2 -0.58 2 -0.580 0 - 0 00 0 - 0 00 0 - 1 -1000 0 - 0 01 0 100.00 0 1000 0 - 1 -1001 2 -1.28 0 1001 2 -1.28 0 00 1 -100.00 0 01 1 -0.58 1 -0.581 0 - 0 00 0 - 0 07 2 0.67 3 0.262 5 -1.50 2 -0.584 0 100.00 3 -0.290 0 100.00 1 -1001 0 100.00 0 1000 0 - 0 01 0 100.00 1 -0.583 1 0.52 2 -0.183 2 -0.18 1 0.521 3 -1.68 2 -1.281 1 -0.58 1 -0.580 1 -100.00 0 00 0 - 0 00 0 - 0 00 0 - 0 01 0 100.00 0 1000 0 - 0 01 0 100.00 0 1000 0 - 0 00 0 - 0 00 1 -100.00 0 00 0 - 0 08 7 -0.45 8 -0.58

Sheet1

2 3 -0.99 3 -0.994 4 -0.58 3 -0.291 1 -0.58 0 00 0 - 1 -1002 1 0.11 2 -0.586 2 0.52 2 0.522 0 100.00 1 0.111 1 -0.58 1 -0.582 1 0.11 1 0.112 2 -0.58 1 0.111 1 -0.58 3 -1.68

10 5 0.11 2 1.035 5 -0.58 3 -0.072 0 100.00 0 1002 0 100.00 0 100

30 30 -0.58 32 -0.651 0 100.00 0 1009 9 -0.58 18 -1.283 5 -1.09 3 -0.580 1 -100.00 0 00 1 -100.00 1 -1000 1 -100.00 1 -1001 1 -0.58 2 -1.280 1 -100.00 1 -1000 0 - 2 -1000 0 100.00 5 -1001 0 - 1 -0.581 0 100.00 0 1002 1 0.11 1 0.110 0 - 1 -1001 1 -0.58 0 1001 0 100.00 2 -1.282 1 0.11 2 -0.580 1 -100.00 0 00 0 - 2 -1001 0 100.00 1 -0.581 1 -0.58 0 1002 2 -0.58 2 -0.581 0 - 1 -0.580 1 -100.00 0 00 2 -100.00 0 00 1 -100.00 0 01 0 100.00 1 -0.580 1 -100.00 0 01 1 -0.58 0 1000 2 -100.00 3 -1000 1 -100.00 0 01 0 100.00 0 1002 1 0.11 1 0.111 1 -0.58 1 -0.581 0 100.00 1 -0.58

11 8 -0.26 9 -0.381 0 100.00 0 1000 1 -100.00 0 1002 1 0.11 0 1000 1 -100.00 0 1000 1 -100.00 1 -100

Sheet1

1 0 100.00 0 1000 0 - 0 01 0 100.00 0 1001 0 - 0 02 1 0.11 0 1001 0 100.00 0 1008 8 -0.58 6 -0.290 0 - 0 01 1 -0.58 1 -0.58

17 20 -0.75 19 -0.691 1 -0.58 1 -0.580 0 - 1 -1002 0 100.00 2 -0.58

14 14 -0.58 14 -0.582 2 -0.58 4 -1.281 1 -0.58 0 1001 0 100.00 1 -0.581 0 100.00 1 -0.585 3 -0.07 4 -0.363 3 -0.58 2 -0.185 3 -0.07 4 -0.365 8 -1.05 5 -0.584 0 100.00 3 -0.290 0 100.00 1 -1000 1 -100.00 3 -1000 1 -100.00 0 00 0 100.00 0 1003 1 0.52 1 0.520 1 -100.00 2 -1001 1 -0.58 0 1000 0 - 0 01 1 -0.58 0 1000 0 - 0 00 0 - 0 02 4 -1.28 4 -1.282 3 -0.99 4 -1.280 1 -100.00 2 -1001 0 100.00 0 1000 1 -100.00 0 04 5 -0.81 11 -1.60 0 - 0 01 0 100.00 1 -0.580 1 -100.00 0 01 0 100.00 0 1001 2 -1.28 1 -0.580 1 -100.00 0 01 1 -0.58 2 -1.282 1 0.11 2 -0.581 1 -0.58 1 -0.581 2 -1.28 0 1001 2 -1.28 1 -0.582 1 0.11 1 0.111 0 - 1 -0.584 2 0.11 1 0.80 0 - 0 00 0 - 0 06 4 -0.18 3 0.11

Sheet1

0 0 - 0 01 0 100.00 0 1001 1 -0.58 2 -1.280 0 - 1 -1003 4 -0.87 4 -0.871 1 -0.58 0 01 0 100.00 0 1001 0 100.00 0 1000 0 - 0 01 1 -0.58 1 -0.580 0 100.00 1 -1000 2 -100.00 1 -1001 1 -0.58 1 -0.580 0 - 0 03 0 100.00 4 -0.873 2 -0.18 2 -0.183 2 -0.18 1 0.520 0 - 0 00 0 100.00 0 1002 2 -0.58 1 0.116 5 -0.40 8 -0.870 2 -100.00 1 -1002 1 0.11 1 0.110 0 - 0 00 0 - 0 00 0 - 0 00 2 -100.00 1 -1001 2 -1.28 0 1001 3 -1.68 0 1001 1 -0.58 1 -0.580 0 - 0 02 0 100.00 0 1003 2 -0.18 1 0.522 2 -0.58 2 -0.580 0 - 0 02 1 0.11 1 0.110 0 - 0 01 0 100.00 0 1001 1 -0.58 1 -0.582 1 0.11 3 -0.990 0 - 0 00 0 - 0 00 0 - 0 01 0 100.00 0 1001 0 100.00 0 1002 1 0.11 1 0.111 1 -0.58 0 1000 0 - 0 01 0 100.00 0 1000 0 - 0 01 1 -0.58 1 -0.580 0 - 0 05 7 -0.92 5 -0.580 1 -100.00 0 1000 0 - 0 01 3 -1.68 2 -1.280 0 - 1 -100

Sheet1

0 0 - 1 -1001 0 100.00 0 1000 0 - 1 -1001 0 100.00 0 1002 2 -0.58 1 0.111 2 -1.28 1 -0.581 0 100.00 0 1002 3 -0.99 5 -1.5

27 14 0.07 15 0.011 0 100.00 0 1001 1 -0.58 1 -0.580 0 - 0 02 1 0.11 1 0.112 2 -0.58 6 -1.683 1 0.52 2 -0.184 3 -0.29 3 -0.29

10 6 -0.07 7 -0.231 1 -0.58 1 -0.583 4 -0.87 1 0.523 1 0.52 2 -0.181 1 -0.58 1 -0.581 0 100.00 0 1004 3 -0.29 3 -0.29

10 4 0.33 6 -0.070 1 -100.00 0 00 0 - 0 01 1 -0.58 1 -0.580 0 - 1 -1001 1 -0.58 2 -1.280 0 - 0 01 0 100.00 0 1001 4 -1.97 1 -0.581 0 - 0 00 0 - 0 01 0 100.00 1 -0.580 0 - 0 02 1 0.11 1 0.110 0 - 0 00 0 - 0 00 1 -100.00 1 -1000 1 -100.00 0 00 0 - 0 00 0 - 1 -1002 0 100.00 0 1000 1 -100.00 1 -1005 7 -0.92 6 -0.770 0 100.00 0 100

22 26 -0.75 22 -0.580 1 -100.00 2 -1000 1 -100.00 0 0

10 25 -1.50 20 -1.282 3 -0.99 4 -1.280 0 - 0 04 1 0.80 0 1005 3 -0.07 3 -0.070 0 - 0 00 1 -100.00 0 0

Sheet1

0 0 100.00 0 1000 2 -100.00 0 1001 0 - 1 -0.581 2 -1.28 1 -0.580 1 -100.00 0 04 1 0.80 0 1001 1 -0.58 0 1000 0 - 0 03 2 -0.18 1 0.520 0 - 0 04 0 100.00 1 0.80 0 - 0 00 0 - 0 01 0 100.00 1 -0.582 4 -1.28 3 -0.992 2 -0.58 2 -0.581 3 -1.68 2 -1.280 0 - 0 01 0 100.00 0 1000 1 -100.00 0 02 1 0.11 0 1000 1 -100.00 0 1000 1 -100.00 3 -1007 3 0.27 1 1.360 0 - 0 0

27 1 2.72 2 2.021 2 -1.28 1 -0.581 0 100.00 0 1000 0 - 0 02 1 0.11 0 1002 1 0.11 3 -0.991 0 100.00 0 1002 0 100.00 2 -0.580 0 - 0 02 2 -0.58 0 1000 2 -100.00 0 1003 4 -0.87 0 1001 2 -1.28 1 -0.588 10 -0.81 12 -0.990 1 -100.00 0 02 1 0.11 2 -0.581 1 -0.58 1 -0.580 0 - 0 02 2 -0.58 0 1003 2 -0.18 2 -0.182 1 0.11 2 -0.580 0 - 2 -1001 1 -0.58 3 -1.680 2 -100.00 3 -1000 1 -100.00 0 01 2 -1.28 1 -0.581 3 -1.68 1 -0.581 2 -1.28 1 -0.581 0 100.00 1 -0.581 0 100.00 0 1002 1 0.11 0 1000 0 100.00 0 100

Sheet1

0 0 - 0 00 0 - 0 00 0 - 0 01 1 -0.58 1 -0.581 1 -0.58 1 -0.580 1 -100.00 0 00 0 - 0 01 2 -1.28 1 -0.581 0 - 1 -0.584 3 -0.29 4 -0.580 1 -100.00 0 01 1 -0.58 1 -0.584 1 0.80 4 -0.583 1 0.52 4 -0.870 1 -100.00 1 -1001 3 -1.68 0 1001 2 -1.28 0 1002 1 0.11 0 1000 0 - 0 01 0 100.00 1 -0.581 0 100.00 1 -0.580 0 - 1 -1001 0 - 0 00 0 - 0 00 0 100.00 0 1000 0 - 0 0

10 7 -0.23 3 0.623 0 100.00 0 1000 2 -100.00 0 00 1 -100.00 1 -1000 1 -100.00 0 06 7 -0.74 2 0.520 0 100.00 0 1000 1 -100.00 0 02 0 100.00 0 1001 1 -0.58 0 00 1 -100.00 0 1003 5 -1.09 2 -0.182 0 100.00 0 1000 1 -100.00 0 01 0 100.00 0 1000 0 - 1 -1000 1 -100.00 2 -1001 1 -0.58 1 -0.584 1 0.80 0 1000 0 - 0 09 6 -0.18 5 0.010 0 - 0 00 0 - 0 01 1 -0.58 1 -0.580 0 - 0 02 2 -0.58 2 -0.580 0 - 0 0

17 18 -0.64 14 -0.391 2 -1.28 2 -1.284 3 -0.29 3 -0.291 1 -0.58 0 0

Sheet1

0 0 - 0 01 1 -0.58 0 00 0 - 1 -1001 0 100.00 0 1000 1 -100.00 1 -1002 2 -0.58 0 1000 0 - 0 00 0 - 1 -1001 1 -0.58 0 100

12 9 -0.29 10 -0.40 1 -100.00 0 03 0 100.00 1 0.520 0 - 1 -1001 1 -0.58 0 02 1 0.11 2 -0.582 0 - 0 01 1 -0.58 0 1001 0 - 0 02 1 0.11 0 1000 1 -100.00 0 00 0 - 0 00 0 - 0 01 2 -1.28 0 1000 1 -100.00 0 01 1 -0.58 0 1006 3 0.11 2 0.522 0 - 1 0.110 0 - 0 0

184 122 -0.17 104 -0.013 3 -0.58 3 -0.580 0 - 0 01 1 -0.58 0 1001 1 -0.58 1 -0.580 0 - 1 -1000 0 - 0 00 0 100.00 0 1002 1 0.11 0 1000 0 100.00 0 1000 0 - 0 01 0 100.00 0 1000 0 - 0 02 1 0.11 1 0.111 0 - 0 00 0 - 0 00 0 - 1 -1002 1 0.11 2 -0.581 0 100.00 0 1000 0 - 0 02 0 100.00 0 1000 0 - 0 01 0 100.00 0 1000 0 - 2 -1002 2 -0.58 2 -0.580 0 - 0 01 0 - 1 -0.582 1 0.11 1 0.112 0 100.00 1 0.11

Sheet1

1 2 -1.28 1 -0.580 0 100.00 0 1002 2 -0.58 1 0.110 0 - 0 00 0 - 1 -1000 1 -100.00 0 00 1 -100.00 1 -1000 0 - 0 00 0 - 0 01 2 -1.28 2 -1.281 1 -0.58 1 -0.580 0 - 1 -1000 0 - 1 -1000 0 - 0 00 0 - 1 -1000 0 - 0 00 1 -100.00 2 -1006 5 -0.40 4 -0.182 0 100.00 2 -0.580 0 - 1 -1002 0 - 0 01 1 -0.58 1 -0.580 1 -100.00 0 1004 1 0.80 1 0.81 0 - 1 -0.580 0 - 0 01 2 -1.28 2 -1.288 8 -0.58 19 -1.454 3 -0.29 3 -0.291 0 100.00 0 1001 1 -0.58 1 -0.580 0 - 0 00 2 -100.00 1 -1002 5 -1.50 4 -1.280 1 -100.00 0 02 1 0.11 1 0.111 2 -1.28 2 -1.283 1 0.52 2 -0.182 0 100.00 0 1000 1 -100.00 1 -1003 0 100.00 1 0.523 1 0.52 4 -0.871 1 -0.58 1 -0.580 1 -100.00 0 01 2 -1.28 0 1001 0 100.00 0 1003 2 -0.18 2 -0.180 0 - 0 00 0 - 0 05 3 -0.07 2 0.331 0 100.00 1 -0.580 0 - 0 02 1 0.11 2 -0.582 1 0.11 2 -0.580 0 - 0 01 1 -0.58 0 1000 0 - 0 0

Sheet1

4 1 0.80 1 0.82 0 100.00 2 -0.582 2 -0.58 0 1000 0 - 0 00 1 -100.00 0 00 0 100.00 1 -1000 0 - 1 -1001 0 100.00 0 1000 1 -100.00 1 -1002 0 100.00 0 1000 0 - 0 03 1 0.52 1 0.523 1 0.52 2 -0.183 2 -0.18 1 0.520 0 - 0 02 0 100.00 2 -0.581 0 - 1 -0.580 0 - 0 00 0 - 0 00 0 100.00 1 -1001 0 100.00 0 1000 1 -100.00 0 00 0 - 0 01 0 100.00 3 -1.683 1 0.52 1 0.521 2 -1.28 0 1001 1 -0.58 1 -0.580 0 - 0 00 0 100.00 0 1002 0 100.00 0 1004 4 -0.58 2 0.111 4 -1.97 2 -1.282 0 - 1 0.111 2 -1.28 0 00 1 -100.00 0 00 1 -100.00 0 03 2 -0.18 1 0.521 0 100.00 0 1000 1 -100.00 0 0

20 21 -0.63 14 -0.230 0 - 0 01 1 -0.58 1 -0.58

32 14 0.24 20 -0.110 1 -100.00 1 -1000 0 - 0 00 0 - 0 08 4 0.11 5 -0.112 2 -0.58 2 -0.582 3 -0.99 0 1001 1 -0.58 0 1000 1 -100.00 0 03 3 -0.58 1 0.520 0 - 0 00 0 - 0 00 0 - 1 -1002 1 0.11 5 -1.5

22 18 -0.38 22 -0.58

Sheet1

12 7 -0.04 6 0.110 0 - 0 02 1 0.11 1 0.115 6 -0.76 2 0.335 2 0.33 4 -0.361 0 - 2 -1.280 1 -100.00 1 -1001 1 -0.58 1 -0.580 0 - 0 00 0 - 0 00 0 - 0 00 0 100.00 0 1004 2 0.11 2 0.112 2 -0.58 1 0.110 0 - 0 00 2 -100.00 2 -1000 1 -100.00 0 00 1 -100.00 1 -1000 0 100.00 1 -1001 1 -0.58 1 -0.581 1 -0.58 0 00 0 - 0 00 0 - 2 -1001 2 -1.28 0 1000 0 - 0 01 0 100.00 0 1000 0 100.00 0 1001 0 100.00 0 1004 0 100.00 2 0.110 0 - 0 00 0 - 0 00 0 - 1 -1003 2 -0.18 1 0.520 0 100.00 0 1000 2 -100.00 0 00 0 - 0 00 1 -100.00 0 01 1 -0.58 1 -0.580 1 -100.00 0 1000 0 - 1 -1001 3 -1.68 2 -1.280 1 -100.00 0 00 0 - 0 00 0 - 0 00 1 -100.00 0 00 1 -100.00 0 02 1 0.11 0 1000 0 - 0 03 3 -0.58 6 -1.280 1 -100.00 0 01 0 100.00 0 1001 1 -0.58 0 1002 0 100.00 1 0.110 1 -100.00 0 00 0 - 0 00 0 - 0 04 2 0.11 4 -0.58

Sheet1

4 1 0.80 2 0.112 1 0.11 2 -0.584 0 100.00 0 1001 0 100.00 1 -0.582 0 100.00 0 1001 0 100.00 0 1001 0 - 0 00 0 - 0 01 1 -0.58 1 -0.580 2 -100.00 2 -1000 0 - 1 -1000 0 100.00 1 -1000 0 - 1 -1002 0 100.00 2 -0.580 0 100.00 0 1000 1 -100.00 0 00 1 -100.00 0 01 0 100.00 1 -0.581 0 100.00 0 1004 4 -0.58 4 -0.584 2 0.11 2 0.110 1 -100.00 1 -1001 1 -0.58 1 -0.581 0 100.00 0 1001 1 -0.58 0 1001 0 - 0 02 1 0.11 0 1000 0 - 1 -1000 0 - 1 -1002 2 -0.58 0 1002 1 0.11 1 0.112 4 -1.28 1 0.111 1 -0.58 2 -1.281 2 -1.28 0 1004 3 -0.29 3 -0.290 1 -100.00 0 00 0 - 1 -1000 0 - 0 00 0 - 0 01 1 -0.58 1 -0.580 1 -100.00 1 -1002 1 0.11 1 0.110 0 - 1 -1001 0 100.00 1 -0.581 3 -1.68 1 -0.581 0 100.00 0 1002 2 -0.58 2 -0.580 1 -100.00 1 -1000 1 -100.00 0 01 0 100.00 1 -0.580 0 - 2 -1000 1 -100.00 1 -1002 0 100.00 0 1000 0 - 0 00 0 - 0 01 0 100.00 1 -0.581 1 -0.58 1 -0.58

Sheet1

0 0 - 0 01 1 -0.58 0 1002 0 100.00 0 1000 0 - 0 01 1 -0.58 2 -1.280 0 - 1 -1000 0 - 0 01 0 100.00 1 -0.580 0 - 3 -1001 2 -1.28 1 -0.580 2 -100.00 0 00 3 -100.00 3 -1000 0 - 0 01 1 -0.58 1 -0.580 1 -100.00 0 01 0 100.00 1 -0.581 1 -0.58 1 -0.580 0 - 1 -1000 0 - 0 00 0 - 0 00 0 - 0 01 0 100.00 1 -0.581 1 -0.58 0 1002 2 -0.58 1 0.111 0 100.00 0 1001 1 -0.58 3 -1.680 0 - 0 01 1 -0.58 0 1000 0 - 1 -1001 0 100.00 0 1000 0 100.00 0 1000 0 100.00 0 1000 1 -100.00 0 00 0 - 0 00 0 100.00 0 1001 1 -0.58 1 -0.584 2 0.11 0 1001 0 100.00 1 -0.580 0 - 0 01 0 - 2 -1.280 0 - 0 02 3 -0.99 2 -0.581 0 100.00 0 1001 1 -0.58 0 1000 0 - 0 03 1 0.52 3 -0.580 0 - 1 -1001 1 -0.58 2 -1.280 0 - 0 01 0 - 0 02 1 0.11 1 0.112 0 100.00 0 1001 0 - 0 00 0 - 0 00 0 - 1 -1000 0 - 0 00 0 - 0 0

Sheet1

1 1 -0.58 0 00 0 - 0 01 0 100.00 1 -0.581 0 100.00 0 1000 0 - 0 02 1 0.11 0 1000 0 - 1 -1001 0 100.00 0 1001 1 -0.58 1 -0.580 0 - 0 01 1 -0.58 1 -0.581 2 -1.28 2 -1.281 0 100.00 0 1000 0 100.00 0 1000 2 -100.00 2 -1001 1 -0.58 0 1000 0 - 0 00 1 -100.00 1 -1000 0 100.00 0 1001 1 -0.58 1 -0.584 2 0.11 3 -0.291 0 100.00 0 1000 0 - 0 00 1 -100.00 0 01 2 -1.28 0 00 0 - 1 -1002 0 100.00 0 1001 0 100.00 0 1000 1 -100.00 1 -1000 0 100.00 0 100

24 1 2.60 1 2.62 1 0.11 1 0.112 2 -0.58 0 1000 0 - 0 00 0 - 0 00 1 -100.00 1 -1001 1 -0.58 0 01 0 100.00 0 1001 0 100.00 1 -0.580 0 - 0 06 3 0.11 3 0.111 2 -1.28 2 -1.280 1 -100.00 0 1000 1 -100.00 0 1000 0 100.00 0 1002 1 0.11 1 0.110 0 100.00 0 100

Sheet1

Drosophila melanogaster

13,746.00

Pfam domain name

79 -0.09 7tm_1 PF0000120 0.08 7tm_2 PF0000210 -0.09 7tm_3 PF00003

124 -0.44 AAA PF0000456 -0.30 ABC_tran PF0000525 -0.92 ATP-synt_ab PF000060 100.00 Cys_knot PF00007

41 0.01 EGF PF00008113 -0.46 GTP_EFTU PF0000958 -0.49 HLH PF0001011 -1.49 HSP20 PF0001115 -0.50 HSP70 PF0001227 -0.54 KH_1 PF0001324 -2.27 Kunitz_BPTI PF000146 0.10 MCPsignal PF000150 100.00 RuBisCO_large PF00016

33 -0.55 SH2 PF0001758 -0.19 SH3_1 PF000187 0.06 TGF_beta PF000194 -1.57 TNFR_c6 PF000204 -0.88 UPAR_LY6 PF00021

16 -0.47 Actin PF0002281 -0.10 Ank PF000239 -0.08 PAN_1 PF00024

96 -0.40 Arf PF0002513 -2.75 Asp PF0002620 -0.19 cNMP_binding PF0002717 0.51 Cadherin PF000280 - Connexin PF000290 - Crystall PF000305 -1.80 Cystatin PF000312 -100.00 Cytochrom_B_C PF000324 -1.57 Cytochrom_B_N PF000335 -0.70 Cytochrom_C PF00034

17 -0.19 dsrm PF0003592 -0.45 efhand PF000364 -0.88 Fer4 PF00037

11 0.63 Filament PF000380 100.00 fn2 PF00040

61 -0.24 fn3 PF000414 -0.47 Globin PF00042

45 -0.86 GST_C PF000433 -0.59 Gp_dh_N PF00044

Number of Drosophila hits

odds ratio (S invicta/

Drosophila)

Pfam Accession

Sheet1

2 0.22 Hemopexin PF00045100 -0.31 Homeobox PF00046124 0.06 ig PF00047

7 -1.44 Insulin PF0004924 -0.66 Kazal_1 PF000502 0.51 Kringle PF000515 -0.41 Laminin_B PF00052

21 -0.19 Laminin_EGF PF0005319 0.09 Laminin_G_1 PF000546 -0.19 Laminin_N PF000557 -0.05 Ldh_1_N PF00056

37 -0.06 Ldl_recept_a PF000579 -0.30 Ldl_recept_b PF00058

38 -1.34 Lectin_C PF0005957 -0.97 Lig_chan PF000606 -0.88 Lipocalin PF00061

13 -2.75 Lys PF0006212 0.16 Myosin_head PF000631 -0.19 Neur PF000642 -0.19 Notch PF00066

86 0.27 p450 PF000674 -0.19 Phospholip_A2_1 PF00068

214 -0.23 Pkinase PF0006934 -0.28 Pyr_redox PF00070

102 -0.35 Ras PF000712 0.22 Response_reg PF000720 100.00 RnaseA PF000741 2.76 RnaseH PF00075

138 -0.44 RRM_1 PF000762 2.21 RVP PF000771 3.55 RVT_1 PF00078

30 -1.51 Serpin PF000795 - Sod_Cu PF000801 0.51 Sod_Fe_N PF000816 -0.37 Peptidase_S8 PF00082

100 -0.56 Sugar_tr PF0008314 -0.19 Sushi PF0008434 -0.50 Thioredoxin PF000853 -0.19 Thyroglobulin_1 PF000863 -1.29 Toxin_1 PF000870 100.00 Trefoil PF00088

253 -1.44 Trypsin PF0008915 0.24 TSP_1 PF0009013 -0.11 Tubulin PF000918 -0.47 VWA PF00092

12 -0.37 VWC PF000936 -0.03 VWD PF000945 -0.41 WAP PF00095

265 -0.20 zf-C2H2 PF0009691 -0.37 zf-C3HC4 PF0009712 1.36 zf-CCHC PF0009816 -0.25 Zona_pellucida PF0010032 0.06 Y_phosphatase PF001022 -100.00 Hormone_1 PF00103

18 -0.03 Hormone_recep PF0010421 -0.19 zf-C4 PF0010575 -0.12 adh_short PF00106

Sheet1

12 0.76 ADH_zinc_N PF001079 0.91 Thiolase_N PF001089 1.38 ketoacyl-synt PF001097 0.35 wnt PF00110

10 -0.41 Fer2 PF0011112 -0.73 Peptidase_C1 PF001121 0.51 Enolase_C PF001130 - Pilin PF001141 1.89 COX1 PF001151 0.51 COX2 PF001167 -1.44 GATase PF00117

13 -0.27 Cpn60_TCP1 PF001181 -0.19 ATP-synt_A PF001192 -0.19 Gln-synt_C PF001201 0.51 TIM PF00121

14 0.06 E1-E2_ATPase PF001220 100.00 Hormone_2 PF00123

105 -1.85 Histone PF001251 -0.19 HTH_1 PF00126

16 -0.66 Alpha-amylase PF001281 -100.00 MHC_I PF00129

69 -0.36 C1_1 PF001301 -100.00 Metallothio PF001316 -0.37 Hexapep PF00132

10 -0.19 tRNA-synt_1 PF0013317 -0.08 Cyclin_N PF0013436 -0.11 COesterase PF001354 -0.19 DNA_pol_B PF001369 -1.69 ATP-synt_C PF001372 -0.19 Lectin_legB PF001390 - Sigma70_r1_2 PF001401 -0.19 peroxidase PF001415 -1.10 Fer4_NifH PF001420 100.00 Interferon PF001431 1.42 DNA_methylase PF001451 1.89 NADHdh PF00146

14 -2.13 Fibrinogen_C PF001470 - Oxidored_nitro PF00148

35 -0.97 Metallophos PF001492 0.22 Cellulase PF00150

32 -0.52 Lipase PF001519 -0.30 tRNA-synt_2 PF00152

49 -0.65 Mito_carr PF001534 0.04 RecA PF00154

17 -0.31 Aminotran_1_2 PF001558 -0.19 Pribosyltran PF001565 -0.41 Pou PF00157

51 -0.46 Sigma54_activat PF001580 100.00 Hormone_3 PF00159

18 -0.37 Pro_isomerase PF001600 100.00 RIP PF001612 -0.88 PGK PF001622 -0.19 Ribosomal_S4 PF001633 -0.59 Ribosomal_S12 PF001640 100.00 HTH_AraC PF001653 -0.59 Cpn10 PF001664 0.04 FGF PF00167

Sheet1

42 -0.12 C2 PF0016866 -0.30 PH PF0016938 -0.14 bZIP_1 PF0017012 -0.03 Aldedh PF0017117 -0.62 Cyt-b5 PF001733 -0.59 Oxidored_molyb PF001749 -0.30 NAD_binding_1 PF00175

23 -0.10 SNF2_N PF001765 -0.41 Ribosomal_S7 PF001779 -0.44 Ets PF00178

33 -0.51 UQ_con PF001797 -0.75 Iso_dh PF001803 -1.29 Ribosomal_L2 PF001810 100.00 Glyco_hydro_19 PF001823 0.51 HSP90 PF001831 -0.19 Hormone_5 PF001840 100.00 OTCace PF001852 -0.88 DHFR_1 PF001860 - Chitin_bind_1 PF00187

28 -1.73 CAP PF001882 -0.88 Ribosomal_S3_C PF001893 -0.59 Cupin_1 PF001907 -0.52 Annexin PF001910 - Xlink PF00193

15 -0.50 Carb_anhydrase PF001940 - Chal_sti_synt_N PF001951 0.91 GerE PF001964 -0.19 2-oxoacid_dh PF001983 -1.29 Catalase PF001995 -0.70 Disintegrin PF00200

36 -0.68 UDPGT PF002016 -0.59 Aminotran_3 PF002022 -0.88 Ribosomal_S19 PF002031 -0.19 DNA_gyraseB PF002044 0.04 TPP_enzyme_M PF002056 -0.37 Lyase_1 PF002066 -0.59 A2M PF002075 0.40 ELFV_dehydrog PF00208

22 -0.51 SNF PF002093 0.32 Ferritin PF00210

24 -0.42 Guanylate_cyc PF002111 0.51 OSCP PF002131 0.91 Calc_CGRP_IAPP PF002141 0.51 OMPdecase PF002150 100.00 Bac_DNA_binding PF002164 -0.19 ATP-gua_Ptrans PF002170 100.00 IGFBP PF002190 100.00 Hormone_4 PF002207 -2.13 PK PF00224

27 0.10 Kinesin PF0022539 -0.76 DnaJ PF0022626 -0.74 Proteasome PF002271 -0.19 TNF PF002297 -0.19 MIP PF002301 -0.19 ATP-synt PF002312 -0.19 Glyco_hydro_1 PF002326 -0.19 PDEase_I PF00233

Sheet1

0 - Tryp_alpha_amyl PF002341 -100.00 Profilin PF002350 - Hormone_6 PF002362 0.22 Ribosomal_L22 PF002373 -1.29 Ribosomal_L14 PF002380 100.00 Resolvase PF00239

35 -0.65 ubiquitin PF002407 -1.03 Cofilin_ADF PF002419 -1.69 DNA_pol_viral_N PF002421 -0.19 NGF PF002432 -0.19 14/03/03 PF00244

13 -1.14 Alk_phosphatase PF0024524 -0.97 Peptidase_M14 PF0024612 -0.59 Aldo_ket_red PF0024822 -0.28 Myb_DNA-binding PF0024919 -0.30 Fork_head PF002501 -0.19 Glyco_hydro_32N PF002512 -0.19 Ribosomal_L16 PF002523 -0.19 Ribosomal_S14 PF002538 -0.32 FKBP_C PF002542 0.22 GSHPx PF002550 - Dehydrin PF002573 -0.19 Flavodoxin_1 PF00258

11 -0.02 Tropomyosin PF002614 -1.57 Calreticulin PF002622 -0.88 Secretin PF002633 -1.29 Tyrosinase PF002641 0.51 TK PF00265

15 -0.41 Aminotran_5 PF002661 -0.19 Ribonuc_red_sm PF002682 -0.88 SASP PF00269

80 -0.25 DEAD PF0027075 -0.20 Helicase_C PF002715 -100.00 Cecropin PF002720 100.00 Serum_albumin PF002732 -0.88 Glycolytic PF002742 -0.19 Ribosomal_L23 PF002760 100.00 SAA PF002772 0.91 Orn_DAP_Arg_deC PF002781 0.51 Ribosomal_L5 PF00281

11 0.05 Pyridoxal_deC PF002820 - Cytochrom_B559a PF002844 0.04 Citrate_synt PF002855 -100.00 Flexi_CP PF002866 -0.19 Na_K-ATPase PF002876 -0.19 GHMP_kinases_N PF002885 -0.41 CPSase_L_chain PF002891 -0.19 Trp_syntA PF002905 -0.41 PALP PF00291

11 -0.19 PAX PF0029215 -0.50 NUDIX PF0029311 -0.79 PfkB PF002942 -100.00 Bac_luciferase PF002962 -0.19 Ribosomal_L3 PF002972 -0.19 Ribosomal_L11 PF002980 - Squash PF002999 0.01 PGAM PF00300

Sheet1

6 0.10 Rubredoxin PF003010 100.00 CAT PF003021 -0.19 Thymidylat_synt PF003038 -1.17 Gamma-thionin PF003047 -1.44 ATP-synt_ab_C PF00306

31 -0.22 CH PF003075 - Bac_DnaA PF003081 -0.19 Sigma54_AID PF003095 -0.41 GATase_2 PF003102 -0.19 Ribosomal_S15 PF003124 -0.88 CSD PF003132 0.22 FBPase PF003161 0.91 Ribonuc_red_lgN PF003173 -0.59 Ribosomal_S2 PF003182 0.22 SRF-TF PF003198 0.13 GATA PF003200 100.00 Thionin PF003210 100.00 Endothelin PF003221 -100.00 Defensin_1 PF00323

15 -0.06 AA_permease PF003240 100.00 Crp PF00325

45 -0.63 Peptidase_S9 PF003262 -0.19 Ribosomal_L30 PF003279 0.45 Acid_phosphat_A PF003281 0.51 Complex1_30kDa PF003294 -0.47 Aconitase PF003300 - Glyco_hydro_17 PF003321 0.51 Ribosomal_S5 PF003334 -0.47 NDK PF00334

48 -0.92 Tetraspannin PF003350 - DNA_pol_viral_C PF003366 -0.88 Gal-bind_lectin PF003373 -0.19 Ribosomal_S10 PF00338

18 -1.13 Arrestin_N PF003390 100.00 IL1 PF003401 0.51 PDGF PF003411 -0.19 PGI PF003421 -0.19 Phosphorylase PF003431 0.91 SecY PF003443 -0.19 Complex1_49kDa PF003461 -0.19 Ribosomal_L6 PF003474 2.01 polyprenyl_synt PF003486 -1.29 Hexokinase_1 PF00349

58 -0.51 Dynamin_N PF003503 0.32 Biopterin_H PF003515 -0.70 TBP PF003522 0.51 Pentaxin PF003543 -0.19 Rieske PF003551 -0.19 LacI PF003562 0.22 Integrin_alpha PF003570 - PTS_EIIA_1 PF003582 -100.00 PTS_EIIA_2 PF003593 1.35 Oxidored_q1 PF003612 0.73 Integrin_beta PF003620 - Casein PF003637 0.06 Biotin_lipoyl PF003641 -0.19 PFK PF00365

Sheet1

2 -0.19 Ribosomal_S17 PF003660 - PTS_EIIB PF003671 1.89 HMG-CoA_red PF003687 -0.34 FGGY_N PF00370

11 -1.20 Hemocyanin_M PF0037222 -0.28 FERM_M PF003732 -100.00 NiFeSe_Hases PF003744 -0.19 SDF PF003752 0.22 MerR PF003760 - Prion PF00377

14 -0.88 ECH PF00378104 -1.10 Chitin_bind_4 PF00379

2 -0.19 Ribosomal_S9 PF003800 - PTS-HPr PF003816 0.10 TFIIB PF003826 -0.59 dCMP_cyt_deam_1 PF003832 -0.88 Molybdopterin PF00384

15 -1.10 Chromo PF003851 0.91 C1q PF003864 -0.19 PI-PLC-Y PF003877 -0.34 PI-PLC-X PF003886 -0.59 2-Hacid_dh PF003895 -1.80 malic PF003900 100.00 PEP-utilizers PF003915 -100.00 GntR PF003921 -0.19 6PGD PF003934 0.37 Cu-oxidase PF003940 - Granulin PF00396

23 -0.28 WW PF0039712 0.04 RrnaAD PF00398

178 -0.13 WD40 PF004002 0.22 ATP-synt_DE PF004013 -0.19 Calponin PF004024 -0.19 HMA PF004036 -0.88 Dockerin_1 PF004043 0.10 Transferrin PF004059 -0.08 ADK PF004063 -0.19 PGM_PMM_IV PF004085 -1.80 Ribosomal_S8 PF004102 -0.19 Ribosomal_S11 PF00411

47 -0.11 LIM PF0041213 -0.35 Peptidase_M10 PF0041313 -0.19 RCC1 PF004151 0.51 Ribosomal_S13 PF004161 -0.19 Ribosomal_S3_N PF004171 0.51 Tubulin-binding PF004180 - Fimbrial PF004192 0.22 Oxidored_q2 PF004201 -100.00 PSII PF004210 - REV PF004240 - VP4 PF004260 100.00 PBS_linker_poly PF00427

30 -1.10 Ribosomal_60s PF004280 100.00 TLV_coat PF004293 -0.19 ATP-synt_B PF00430

29 -0.12 CUB PF004316 -0.19 Prenyltrans PF00432

Sheet1

18 -0.51 Pkinase_C PF0043318 0.29 Spectrin PF004351 -0.19 SSB PF00436

55 -0.48 GSPII_E PF004371 -0.19 S-AdoMet_synt_N PF00438

21 -0.24 Bromodomain PF004390 - TetR_N PF00440

15 -0.50 Acyl-CoA_dh_1 PF0044123 0.05 UCH PF004431 -0.19 Ribosomal_L36 PF004441 -0.19 Ribonuclease_T2 PF004452 -0.19 HSF_DNA-bind PF00447

25 -0.32 SRP54 PF004480 100.00 Urease_alpha PF004495 -1.10 Peptidase_S10 PF004500 - Toxin_2 PF004513 -0.19 Bcl-2 PF004521 -0.19 Ribosomal_L20 PF00453

11 -0.28 PI3_PI4_kinase PF004540 100.00 DeoR PF004553 -1.29 Transketolase_N PF004560 - Glyco_hydro_11 PF004576 -0.19 WHEP-TRS PF00458

10 -0.41 Inositol_P PF004590 - Flg_bb_rod PF00460

25 -0.63 Glutaredoxin PF004623 -1.29 SHMT PF004642 -0.19 Fe-ADH PF004654 -0.19 Ribosomal_L10 PF004668 0.04 KOW PF004670 - Ribosomal_L34 PF004681 -100.00 F-protein PF004692 -100.00 Ribosomal_L33 PF004713 -0.19 RF-1 PF004721 0.91 CRF PF00473

19 -0.65 SSF PF004740 100.00 IGPD PF004752 0.22 DNA_pol_A PF004764 -0.19 IMPDH PF004783 -1.29 G6PD_N PF004790 - ROK PF00480

14 -0.34 PP2C PF004817 -1.44 GSPII_F PF004824 -0.47 NTP_transferase PF004831 -0.19 Pro_CA PF004847 0.27 PRK PF004850 - Trans_reg_C PF00486

16 -0.07 FA_desaturase PF004877 -0.34 MutS_V PF004881 -100.00 IL6 PF004891 -0.19 ALAD PF004902 -0.19 Arginase PF00491

11 0.05 MCM PF004932 -0.88 SQS_PSY PF004940 100.00 SBP_bac_5 PF00496

27 -0.26 SBP_bac_3 PF0049717 -0.25 FHA PF00498

Sheet1

1 -0.19 Oxidored_q3 PF004990 100.00 Late_protein_L1 PF00500

29 -0.22 AMP-binding PF0050130 -0.50 G-alpha PF0050331 -0.36 HMG_box PF005051 -100.00 Flu_NP PF005062 -100.00 Oxidored_q4 PF005071 -100.00 PPV_E2_N PF005082 -100.00 Hemagglutinin PF005091 1.42 COX3 PF005100 - PPV_E2_C PF005111 0.51 HisKA PF00512

34 -0.05 Arm PF00514103 -0.23 TPR_1 PF00515

0 100.00 GP120 PF005164 -0.19 GP41 PF005170 100.00 E6 PF005181 -0.19 PPV_E1_C PF00519

50 -0.06 Ion_trans PF005202 0.22 DNA_topoisoIV PF005210 - VPR PF005220 - Fusion_gly PF005230 - PPV_E1_N PF005242 -0.88 Crystallin PF005250 100.00 Dicty_CTDC PF005261 1.42 E7 PF005270 100.00 BPD_transp_1 PF005285 - HlyD PF005294 -0.19 SRCR PF005308 0.37 Death PF00531

14 -0.26 BRCT PF005337 -0.34 Glycos_transf_1 PF00534

22 -0.71 Glycos_transf_2 PF0053535 -0.28 SAM_1 PF005367 -2.13 Toxin_3 PF00537

25 -1.21 Linker_histone PF005381 -0.19 Tat PF005390 - Gag_p17 PF005401 0.91 Ribosomal_L12 PF005420 100.00 Pec_lyase_C PF005440 - Ribonuclease PF005450 - Urease_gamma PF005470 100.00 Peptidase_C3 PF005485 -0.70 Ligase_CoA PF005495 1.46 PP-binding PF005503 -0.59 Formyl_trans_N PF005510 - Integrase PF005524 -0.47 RHD PF005540 - Endotoxin_M PF005551 -0.19 LHC PF00556

10 -0.19 Peptidase_M24 PF005577 -0.52 Vpu PF00558

130 -0.29 LRR_1 PF0056066 -0.35 Abhydrolase_1 PF005613 0.10 RNA_pol_Rpb2_6 PF005620 100.00 EAL PF005633 -0.19 PB1 PF00564

Sheet1

1 -0.19 SNase PF0056523 -0.28 TBC PF0056618 0.01 TUDOR PF005675 -0.19 WH1 PF00568

16 -0.56 ZZ PF005693 -0.19 HRDC PF005706 0.32 CBS PF005714 -0.88 Ribosomal_L13 PF005722 0.22 Ribosomal_L4 PF005733 -0.59 CLP_protease PF005747 -0.05 S1 PF005752 0.22 Transthyretin PF00576

27 -0.65 AhpC-TSA PF005785 -0.19 tRNA-synt_1b PF005796 -0.19 UvrD-helicase PF005809 -0.44 Rhodanese PF005811 -0.19 Usp PF00582

42 -0.71 Acetyltransf_1 PF005834 -1.57 SecE PF005843 -0.19 AIRS PF00586

11 -0.19 tRNA-synt_2b PF005873 -0.59 SpoU_methylase PF005881 2.45 Phage_integrase PF005891 0.51 TP_methylase PF005900 - TonB_dep_Rec PF00593

65 -0.17 PDZ PF005952 -0.88 Aldolase_II PF005961 -100.00 Flu_M1 PF005980 100.00 Flu_M2 PF005991 0.91 Flu_NS2 PF006010 - Flu_PB1 PF006020 - Flu_PA PF006030 - IRF PF006050 100.00 Glycoprotein_B PF006060 - Adeno_shaft PF006085 -0.19 DAGK_acc PF006098 -0.47 DEP PF006106 -0.03 FCH PF00611

33 -0.51 IQ PF006123 0.32 PI3Ka PF006135 -1.10 PLDc PF006149 0.18 RGS PF006156 -0.03 RasGAP PF00616

10 -0.29 RasGEF PF006179 -0.44 RasGEF_N PF006182 -0.88 CARD PF00619

20 - RhoGAP PF0062024 -0.07 RhoGEF PF0062112 -0.27 SPRY PF006224 -0.47 RNA_pol_Rpb1_2 PF00623

21 -0.59 Guanylate_kin PF006257 -0.34 Gelsolin PF00626

30 -0.95 UBA PF0062767 -0.23 PHD PF006286 -0.88 MAM PF006296 0.32 Filamin PF006307 -0.19 G-gamma PF00631

Sheet1

14 0.12 HECT PF006325 -0.41 HHH PF006331 0.51 BRCA2 PF006345 - Motile_Sperm PF006353 0.32 Ribonuclease_3 PF00636

12 -0.37 Clathrin PF006376 -0.37 Ran_BP1 PF006385 -0.70 Rotamase PF00639

15 -0.26 PID PF0064013 -0.27 zf-RanBP PF0064124 -0.59 zf-CCCH PF0064216 -0.19 zf-B_box PF006432 0.51 PARP PF006440 100.00 zf-PARP PF00645

36 -0.03 F-box PF006462 -0.88 EF1G PF006474 0.37 Peptidase_C2 PF006480 100.00 Copper-fist PF00649

30 -0.09 CRAL_TRIO PF0065067 -0.25 BTB PF0065115 -0.95 Ricin_B_lectin PF006529 -0.44 BIR PF006533 0.10 Voltage_CLC PF006547 -0.05 Peptidase_C14 PF006563 -0.19 Lipase_GDSL PF006572 -0.88 PABP PF006582 0.22 POLO_box PF006592 -100.00 SRP1_TIP1 PF006600 - Matrix PF006612 -0.19 Oxidored_q1_N PF00662

22 -0.28 ABC_membrane PF006642 1.83 rve PF006654 -0.47 FAD_binding_1 PF006671 -100.00 Flagellin_N PF006697 -0.52 AdoHcyase_NAD PF006703 -0.59 HAMP PF006721 0.91 Ribosomal_L5_C PF006732 -100.00 DUP PF006748 -0.66 Peptidase_M16 PF006758 -0.47 E1_dh PF006760 100.00 Lum_binding PF006777 -0.05 EFG_C PF006791 0.91 Plectin PF006812 -0.19 HMGL-like PF006821 1.20 TB PF006836 0.22 DnaJ_CXXCXGXG PF00684

13 -0.45 Sulfotransfer_1 PF006854 -1.57 CBM_20 PF006864 -1.57 Ribosomal_L1 PF006877 0.35 TGFb_propeptide PF00688

12 -0.73 Cation_ATPase_C PF006899 -0.44 Cation_ATPase_N PF006900 - OmpA PF006911 -100.00 dUTPase PF006922 -0.88 Herpes_TK PF006934 -0.88 Aconitase_C PF006942 0.22 vMSA PF00695

Sheet1

1 -0.19 AA_kinase PF006960 100.00 PRAI PF006973 2.21 Acyl_transf_1 PF006980 - Urease_beta PF006990 100.00 Flagellin_C PF007000 - DHDPS PF00701

35 -0.57 Hydrolase PF007022 -0.19 Glyco_hydro_2 PF00703

16 -0.76 Glyco_hydro_18 PF007043 -1.29 PCNA_N PF007051 -0.19 Toxin_4 PF007062 -0.88 IF3_C PF007078 -1.57 Acylphosphatase PF007082 -0.88 Adenylsucc_synt PF007092 -0.88 Asparaginase PF007100 - Defensin_beta PF007111 -0.19 DNA_pol3_beta PF007120 - Hirudin PF007132 -0.88 IFN-gamma PF007141 -100.00 IL2 PF007150 - Peptidase_S21 PF007163 0.10 Peptidase_S24 PF007171 -100.00 Polyoma_coat PF007182 -0.88 Pyrophosphatase PF007191 -100.00 TMV_coat PF007212 0.22 Glyco_hydro_16 PF007222 0.73 Glyco_hydro_15 PF007231 -0.19 Oxidored_FMN PF007243 -0.59 3HCDH PF007250 100.00 IL10 PF007261 -0.19 IL4 PF007275 - Glyco_hydro_20 PF007280 - Viral_coat PF007292 -0.88 HhH-GPD PF007303 -1.29 AIRC PF00731

17 0.38 GMC_oxred_N PF007325 -0.19 Asn_synthase PF007330 100.00 CBM_1 PF00734

25 -0.84 Septin PF007352 0.51 EF1_GNE PF007361 -0.19 PsbH PF007372 -100.00 X PF007391 -100.00 Parvo_coat PF007400 - Homoserine_dh PF007423 0.10 FMO-like PF007431 -100.00 GlutR_dimer PF007451 0.51 Gram_pos_anchor PF007461 -0.19 Viral_DNA_bp PF007470 100.00 Calpain_inhib PF007483 0.32 tRNA-synt_1c PF007495 -0.70 tRNA-synt_1d PF007504 -0.47 DM PF007515 -0.41 XPG_N PF007528 -0.66 Lactamase_B PF00753

12 -0.03 F5_F8_type_C PF007547 -0.34 Carn_acyltransf PF00755

19 -0.30 Esterase PF00756

Sheet1

5 0.15 Furin-like PF007570 100.00 Glyco_hydro_9 PF007590 100.00 Polyoma_coat2 PF007612 -0.88 Ferrochelatase PF007622 0.22 THF_DHG_CYH PF007632 -0.19 Arginosuc_synth PF007641 -0.19 ETF_alpha PF007661 -100.00 Poty_coat PF00767

20 -0.14 ERM PF007692 -0.88 Peptidase_C5 PF007707 -2.13 FHIPEP PF007710 100.00 DnaB PF007722 -0.19 RNB PF007731 1.20 Dioxygenase_C PF007751 -0.19 Glyco_transf_29 PF007772 -0.88 DIX PF007784 -0.88 BTK PF007796 0.10 CNH PF00780

11 -0.51 DAGK_cat PF0078129 -0.26 DSPc PF007825 - MyTH4 PF007847 -0.34 PBD PF00786

16 0.04 PX PF0078715 - RA PF007889 -0.44 UBX PF007895 -0.41 VHS PF007905 -0.70 ZU5 PF007915 -0.70 PI3K_C2 PF007922 -100.00 DAHP_synth_1 PF007932 0.22 PI3K_rbd PF007948 0.04 CN_hydrolase PF007951 -100.00 PSI_8 PF007960 100.00 Arena_glycoprot PF007981 -100.00 Gemini_AL1 PF007990 100.00 PDT PF008002 -0.19 PKD PF008010 100.00 Glycoprotein_G PF00802

13 -0.04 Syntaxin PF008042 -0.19 Pentapeptide PF008055 -1.80 PUF PF008060 - Apidaecin PF00807

102 -2.05 CBFD_NFYB_HMF PF008080 - Pterin_bind PF008092 -0.19 ER_lumen_recept PF008102 0.22 Ephrin PF008122 -100.00 FliP PF008132 0.51 Peptidase_M22 PF008140 - Histidinol_dh PF008150 - Histone_HNS PF008164 -0.47 IMS PF008172 -0.19 PEPCK PF008218 -0.47 PMP22_Claudin PF008220 100.00 Ribosomal_L15e PF008273 -0.19 Ribosomal_L18e PF008281 -0.19 Ribosomal_L21p PF008290 - Ribosomal_L28 PF008302 -0.19 Ribosomal_L29 PF00831

Sheet1

1 -0.19 Ribosomal_L39 PF008321 0.51 Ribosomal_S17e PF008331 -0.19 Ribul_P_3_epim PF008342 -0.88 SNAP-25 PF008352 -0.88 Stathmin PF008362 -0.19 TCTP PF008381 -0.19 Cys_rich_FGFR PF008390 - Protamine_P2 PF008411 -0.19 Arena_nucleocap PF008431 -0.19 Hanta_nucleocap PF008460 - AP2 PF008470 - Ring_hydroxyl_A PF008482 0.22 PseudoU_synth_2 PF008495 -0.19 Hist_deacetyl PF008503 -1.29 Peptidase_C6 PF008513 0.10 Glyco_transf_10 PF008524 0.04 Runt PF008533 -100.00 PTR2 PF008548 0.04 PWWP PF00855

29 -0.46 SET PF008563 -0.19 Isochorismatase PF00857

32 -1.09 ASC PF008580 100.00 CTF_NFI PF008591 0.51 Xan_ur_permease PF008601 0.51 Ribosomal_L18p PF008610 - P2X_receptor PF008641 -0.19 Osteopontin PF008651 -100.00 Ring_hydroxyl_B PF008665 -0.41 XPG_I PF008671 0.51 Transglut_N PF008682 -100.00 P53 PF008701 -100.00 Acetate_kinase PF008710 - Transposase_mut PF008727 -1.44 ACR_tran PF008730 100.00 PRD PF008744 -0.88 DNA_photolyase PF008759 -0.77 Innexin PF008762 -0.88 CIMR PF008782 -0.88 Defensin_propep PF008792 -0.88 Nebulin PF008801 -0.19 Nitroreductase PF008811 -100.00 Zn_dep_PLPC PF00882

10 -1.80 Peptidase_M17 PF0088332 -1.26 Sulfatase PF008841 -0.19 Ribosomal_S16 PF00886

10 -0.88 ACBP PF008878 -0.32 Cullin PF008882 0.22 EF_TS PF00889

43 -0.12 FAD_binding_2 PF008902 -0.19 Methyltransf_2 PF00891

16 -0.07 EamA PF008921 -0.19 Multi_Drug_Res PF008930 100.00 Luteo_coat PF008944 -1.57 ATP-synt_8 PF00895

19 -0.19 ThiF PF008991 -0.19 Ribosomal_S4e PF009000 100.00 Orbi_VP5 PF00901

Sheet1

0 - TatC PF009023 -1.29 Glyoxalase PF009030 100.00 Hepatitis_core PF009068 0.37 T-box PF009071 -100.00 dTDP_sugar_isom PF009082 0.22 Ammonium_transp PF00909

76 -0.51 RNA_helicase PF009100 - Transgly PF009120 - Trypan_glycop PF009130 - Calici_coat PF00915

10 - Sulfate_transp PF009165 -0.19 MATH PF00917

12 -2.67 Gastrin PF009182 -0.19 UPF0004 PF009191 -100.00 Lipoprotein_2 PF009210 - Phosphoprotein PF009221 -0.19 Transaldolase PF009232 -0.88 MS_channel PF009243 -0.19 Transglut_C PF009274 -0.47 Adap_comp_sub PF009289 0.18 Exonuc_X-T PF009297 -0.34 DPPIV_N PF00930

43 -0.48 NB-ARC PF009314 -0.88 IF_tail PF009320 - Glyco_hydro_3 PF009330 100.00 PE PF009341 0.91 Ribosomal_L44 PF009350 100.00 BMC PF009364 -100.00 Corona_nucleoca PF009372 -0.88 Lipoprotein_3 PF009388 -0.66 Na_sulph_symp PF009391 0.51 RNA_pol PF009405 -0.70 FAD_binding_5 PF009411 -100.00 Peptidase_S3 PF009441 -100.00 Rhabdo_ncap PF009450 100.00 Pico_P2A PF009470 - Flavi_NS1 PF009481 -100.00 Peptidase_S7 PF009490 - ABC-3 PF009504 -0.47 Arteri_Gl PF009511 -0.19 Glycos_transf_4 PF009530 100.00 S_locus_glycop PF009543 0.10 HCO3_cotransp PF009554 -0.88 NAP PF009568 -0.19 Synaptobrevin PF009571 -0.19 GMP_synt_C PF009585 -1.80 Phage_lysozyme PF009591 -100.00 Neocarzinostat PF009600 - LAGLIDADG_1 PF009619 -1.69 A_deaminase PF009620 - Cohesin PF009631 -100.00 Elicitin PF009641 0.51 TIMP PF009650 - Barwin PF009674 0.04 FAD_binding_6 PF009700 - EIAV_GP90 PF009710 100.00 Flavi_NS5 PF00972

Sheet1

3 -1.29 Paramyxo_ncap PF009732 -0.88 Rhabdo_glycop PF00974

14 0.22 Thioesterase PF009751 -100.00 ACTH_domain PF009766 -0.19 His_biosynth PF009770 100.00 RdRP_2 PF009780 100.00 Reovirus_cap PF009790 - Rota_Capsid_VP6 PF009800 100.00 Rota_NS53 PF009811 -0.19 Glyco_transf_20 PF009821 0.51 UDPG_MGDP_dh PF009841 -100.00 MSA_2 PF009850 - DNA_gyraseB_C PF009861 -0.19 CPSase_sm_chain PF00988

16 -0.47 PAS PF009891 -100.00 GGDEF PF009902 0.73 Troponin PF009921 1.76 MoCF_biosynth PF009946 -0.59 Sec1 PF009953 -1.29 GDI PF009965 -0.19 Na_H_Exchanger PF009992 0.22 RNA_pol_A_bac PF010000 100.00 HCV_NS4b PF010011 0.51 Flavi_NS2B PF010021 -100.00 Flavi_capsid PF010030 100.00 Flavi_M PF010046 -0.59 IRK PF010075 - IF-2B PF010080 100.00 Oxidored_q1_C PF010109 -0.44 PQQ PF010112 -0.19 ETF PF010121 0.51 Uricase PF010141 -100.00 Ribosomal_S3Ae PF010151 -100.00 Ribosomal_L27 PF010162 -0.88 STAT_alpha PF010172 -0.19 GTP1_OBG PF010183 0.10 G_glu_transpept PF010191 -100.00 Ribosomal_L40e PF010200 100.00 TYA PF010210 100.00 HTH_5 PF010220 100.00 Colicin PF010248 -0.07 GrpE PF010252 -0.19 TatD_DNase PF010269 -1.00 UPF0005 PF010271 -0.19 Topoisom_I PF010280 100.00 NusB PF010294 0.04 Recep_L_domain PF010304 -0.47 Dynamin_M PF010310 100.00 FecCD PF010325 -1.10 Somatomedin_B PF01033

41 -0.68 Syndecan PF010342 -100.00 DNA_binding_1 PF010352 -0.19 AsnC_trans_reg PF010372 0.22 Carboxyl_trans PF010395 -0.19 UbiA PF010409 -1.00 DegT_DnrJ_EryC1 PF010412 -0.88 Ribonuc_L-PSP PF01042

Sheet1

0 100.00 SecA_PP_bind PF010434 0.04 Vinculin PF010440 100.00 MarR PF010478 -1.57 PNP_UDP_1 PF010484 -0.19 Cadherin_C PF010490 100.00 Rep_3 PF010510 100.00 SpoA PF010529 -1.00 Cys_Met_Meta_PP PF010530 100.00 MMTV_SAg PF010543 0.10 Glyco_hydro_31 PF01055

11 -1.49 Myc_N PF0105617 -0.72 Parvo_NS1 PF010572 -0.88 Oxidored_q6 PF010581 -0.19 Oxidored_q5_N PF010592 -0.88 DUF290 PF01060

19 0.34 ABC2_membrane PF010616 -0.37 Bestrophin PF010621 0.51 Aminotran_4 PF01063

10 -0.54 Activin_recp PF010640 100.00 Adeno_hexon PF010657 -0.52 CDP-OH_P_transf PF010663 -0.19 Calpain_III PF010673 0.51 DNA_ligase_A_M PF010684 0.22 FMN_dh PF010705 -0.70 GARS_A PF01071

34 -0.10 3Beta_HSD PF010739 -1.00 Glyco_hydro_38 PF010741 -100.00 Glyco_transf_9 PF010750 100.00 NIR_SIR PF01077

63 -0.40 Mg_chelatase PF010781 -0.19 Hint PF01079

20 -1.10 Presenilin PF010800 100.00 Aldolase PF010814 -0.19 Cu2_monooxygen PF010825 -0.19 Cutinase PF010833 -1.29 Ribosomal_S18 PF010842 -0.88 HH_signal PF010851 -0.19 Clathrin_lg_ch PF010861 -0.19 GalP_UDP_transf PF010874 -0.47 Peptidase_C12 PF010882 -0.19 Ribosomal_S19e PF010902 -0.88 PTN_MK_C PF010913 -1.29 Ribosomal_S6e PF010920 100.00 Clusterin PF01093

25 0.15 ANF_receptor PF010949 0.39 TFIIS_C PF010963 -0.19 Defensin_2 PF010973 0.32 Uteroglobin PF010991 -0.19 HMG14_17 PF011013 0.10 Glycophorin_A PF011021 0.51 Bac_surface_Ag PF011031 -100.00 Bunya_NS-S PF01104

16 -0.88 EMP24_GP25L PF011053 -1.29 NifU PF011060 100.00 MP PF011076 -0.03 Tissue_fac PF011080 100.00 GM_CSF PF01109

Sheet1

2 -0.88 CKS PF011115 -0.41 Asparaginase_2 PF011126 -0.59 DapB_N PF011131 -0.19 F_actin_cap_B PF011150 100.00 F_bP_aldolase PF01116

17 -0.62 Semialdhyde_dh PF011183 0.32 DNA_mis_repair PF011191 -0.19 Alpha_L_fucos PF011208 -0.66 CoaE PF011211 -0.19 Cobalamin_bind PF011220 100.00 Stap_Strp_toxin PF011233 -0.59 MAPEG PF011241 -0.19 G10 PF011251 -0.19 Heme_oxygenase PF011264 -0.88 Sdh_cyt PF011272 -0.19 IspD PF011280 100.00 ART PF01129

13 -0.45 CD36 PF011302 -0.88 Topoisom_bac PF011310 100.00 EFP PF011321 0.51 ER PF01133

25 -0.36 GIDA PF0113422 -0.45 PCMT PF011351 -100.00 Peptidase_U32 PF011362 -0.88 RTC PF011376 -0.19 RNase_PH PF011381 -0.19 UPF0027 PF011390 100.00 Gag_MA PF011400 100.00 Gag_p12 PF011411 -0.19 TruD PF011421 -0.19 CoA_trans PF01144

13 -0.81 Band_7 PF011453 -0.19 Caveolin PF011461 -0.19 Crust_neurohorm PF011471 0.51 CTP_transf_1 PF011481 -0.19 GDA1_CD39 PF01150

20 0.08 ELO PF011511 -100.00 Bac_globin PF011524 0.62 Glypican PF011531 -0.19 HMG_CoA_synt_N PF01154

14 0.17 HypA PF011553 -1.29 IU_nuc_hydro PF011561 -100.00 Ribosomal_L21e PF011571 0.51 Ribosomal_L36e PF011581 -0.19 Ribosomal_L6e PF011590 100.00 Opiods_neuropep PF011609 -1.69 PBP PF01161

28 -0.22 RIO1 PF011632 -0.88 Ribosomal_S21 PF011658 0.51 TSC22 PF011662 -0.19 Tub PF011671 -0.19 Ala_racemase_N PF011682 -0.88 UPF0016 PF01169

12 -0.73 UPF0020 PF011703 -0.59 ATP_bind_3 PF011712 -0.19 SBDS PF011720 100.00 SNO PF01174

Sheet1

2 -0.19 eIF-1a PF011761 -100.00 Cu_amine_oxid PF011795 -0.19 DHO_dh PF011802 -0.19 Glucosamine_iso PF011820 100.00 Hydrophobin PF011852 -0.88 Lysyl_oxidase PF011860 100.00 MR_MLE PF011885 -0.41 Nol1_Nop2_Fmu PF011890 100.00 Pollen_Ole_e_I PF011901 0.51 RNA_pol_Rpb5_C PF011911 0.51 RNA_pol_Rpb6 PF011924 -0.47 RNA_pol_L PF011932 -0.88 RNA_pol_N PF011941 -100.00 Ribosomal_L17 PF011964 -100.00 Ribosomal_L31 PF011971 -100.00 Ribosomal_L31e PF011982 0.51 Ribosomal_L34e PF011992 -0.19 Ribosomal_S28e PF012003 -0.59 Ribosomal_S8e PF012018 -0.19 SKI PF012020 100.00 GSPII_N PF012032 -0.19 Trehalase PF012041 -100.00 UPF0029 PF012051 0.51 SirA PF012067 0.17 Dus PF012071 0.51 URO-D PF01208

17 -0.02 Ubie_methyltran PF0120915 -0.70 NAD_Gly3P_dh_N PF0121018 -0.37 Beta_elim_lyase PF012127 0.27 CAP_N PF01213

17 -2.33 CK_II_beta PF012148 -0.19 COX5B PF012153 -0.19 Calsequestrin PF012168 -0.47 Clat_adaptor_s PF012171 -0.19 Coprogen_oxidas PF012182 -0.88 DAGK_prokar PF012190 100.00 DHquinase_II PF012203 0.10 Dynein_light PF012211 -0.19 ERG4_ERG24 PF01222

13 -2.06 Endonuclease_NS PF012230 100.00 Mur_ligase PF012251 -100.00 Form_Nir_trans PF012263 -100.00 GTP_cyclohydroI PF012270 100.00 Gly_radical PF012281 -100.00 Glyco_hydro_39 PF012297 -0.75 HIT PF012300 100.00 Mannitol_dh PF012321 0.51 NMT PF012330 100.00 NNMT_PNMT_TEMT PF012340 100.00 Na_Ala_symp PF012356 -0.03 Oxysterol_BP PF012371 0.91 PMI_typeI PF012383 0.32 PPTA PF012392 -100.00 PSI_PSAK PF012411 0.51 PTPS PF012424 -100.00 Pyridox_oxidase PF012434 0.22 Peptidase_M19 PF01244

Sheet1

1 0.51 Ribosomal_L19 PF012452 -0.19 Ribosomal_L24e PF012461 0.51 Ribosomal_L35Ae PF012477 -0.34 Ribosomal_L7Ae PF012481 0.51 Ribosomal_S21e PF012491 0.51 Ribosomal_S6 PF012501 0.51 Ribosomal_S7e PF012510 100.00 Peptidase_A8 PF012525 -0.41 SUI1 PF012532 1.32 Prenyltransf PF012551 0.51 Carb_kinase PF012562 -0.19 Complex1_24kDa PF012575 -0.19 zf-dskA_traR PF012582 -0.88 SAICAR_synt PF012591 0.91 AP_endonuc_2 PF01261

16 -0.56 AlaDh_PNT_C PF012626 -0.88 Aldose_epim PF012631 -0.19 Cyto_heme_lyase PF01265

52 -0.08 DAO PF012662 -0.19 F-actin_cap_A PF012671 0.51 FTHFS PF012685 -0.70 Fibrillarin PF012690 100.00 Granin PF012711 -0.19 GreA_GreB PF012720 100.00 LBP_BPI_CETP PF012730 100.00 Malate_synthase PF012741 -0.19 Myelin_PLP PF012751 -0.19 OKR_DC_1 PF012760 100.00 Oleosin PF012770 100.00 Parathyroid PF012791 0.51 Ribosomal_L19e PF012801 0.51 Ribosomal_L9_N PF012812 -0.88 Ribosomal_S24e PF012821 -100.00 Ribosomal_S26e PF01283

10 -0.41 MARVEL PF012841 -0.19 TEA PF01285

14 -0.26 XPA_N PF012864 -0.88 eIF-5a PF012871 -100.00 HPPK PF012882 -0.88 Thymosin PF012900 100.00 LIF_OSM PF012917 -2.13 Ni_hydr_CYTB PF012922 -0.88 Ribosomal_L13e PF012942 1.69 SBP_bac_9 PF012970 100.00 Lipoprotein_5 PF012985 -0.41 Lamp PF012992 -0.88 Sua5_yciO_yrdC PF013003 -1.29 Glyco_hydro_35 PF013017 -0.52 CAP_GLY PF013021 -100.00 Egg_lysin PF013030 100.00 Gas_vesicle_C PF013044 -0.19 LacY_symp PF013060 100.00 Plant_vir_prot PF013070 100.00 Chlam_OMP PF013081 -100.00 Bac_export_1 PF013110 100.00 Bac_export_2 PF013121 -100.00 Bac_export_3 PF01313

Sheet1

0 100.00 AFOR_C PF013146 -0.59 Ald_Xan_dh_C PF013150 100.00 Arg_repressor PF013161 -0.19 Bromo_coat PF013181 -0.19 Colicin_Pyocin PF013202 0.22 Creatinase_N PF013211 0.91 Cytochrom_C_2 PF01322

10 -1.39 DSBA PF013230 100.00 Diphtheria_R PF013241 -0.19 Fe_dep_repress PF013250 100.00 PPDK_N PF013263 -1.29 Pep_deformylase PF013270 100.00 Peroxidase_2 PF013281 -0.19 Pterin_4a PF013290 100.00 RuvA_N PF013305 -0.70 mRNA_cap_enzyme PF013312 0.51 DED PF01335

10 -0.09 tRNA_anti PF013360 100.00 Barstar PF013370 100.00 CheB_methylest PF013390 100.00 MetJ PF013401 0.51 SAND PF013425 -1.80 Peptidase_S49 PF01343

17 -0.02 Kelch_1 PF013442 1.07 DUF11 PF013451 -0.19 FKBP_N PF013464 0.83 Vitellogenin_N PF013471 -100.00 Intron_maturas2 PF013480 100.00 Flavi_NS4B PF013491 -0.19 Flavi_NS4A PF013502 -0.19 RNase_HII PF013514 -100.00 KRAB PF013520 100.00 GFP PF013530 100.00 HIPIP PF013551 -0.19 A_amylase_inhib PF013561 1.42 Transposase_1 PF013591 -0.19 Tautomerase PF01361

35 -0.05 FYVE PF013630 100.00 Peptidase_C25 PF013642 -0.19 RYDR_ITPR PF013651 -100.00 PRTP PF013663 -0.19 5_3_exonuc PF013671 -0.19 DHH PF013685 -0.19 Sec7 PF01369

59 -0.14 Epimerase PF013701 -0.19 Trp_repressor PF013710 100.00 Melittin PF013720 100.00 Enterotoxin_a PF013750 100.00 Enterotoxin_b PF013761 -100.00 IgG_binding_B PF013781 0.51 Porphobil_deam PF013791 -0.19 SIS PF013807 0.35 HTH_3 PF013810 100.00 Avidin PF013822 -0.19 PHO4 PF013840 100.00 Transposase_2 PF013850 100.00 Ribosomal_L25p PF01386

Sheet1

0 100.00 Synuclein PF013876 -0.03 ARID PF013883 -0.19 SEA PF01390

17 -0.19 Collagen PF0139111 -0.19 Fz PF013926 -1.29 Chromo_shadow PF013931 -0.19 Clathrin_propel PF01394

45 -2.90 PBP_GOBP PF013954 -0.88 zf-C4_Topoisom PF013962 -0.88 Terpene_synth PF01397

10 -0.70 Mov34 PF0139816 -0.07 PCI PF0139914 -0.63 Astacin PF014006 -0.59 Peptidase_M2 PF014011 -100.00 RHH_1 PF014027 -0.05 Sema PF014031 -0.19 Ephrin_lbd PF014040 100.00 PsbT PF014059 -0.44 tRNA-synt_1e PF014060 100.00 Gemini_AL3 PF014079 -1.29 GFO_IDH_MocA PF014086 -0.19 tRNA-synt_2d PF014090 100.00 COLFI PF014103 -0.59 tRNA-synt_2c PF01411

13 -0.81 ArfGap PF014122 -0.19 C4 PF014133 0.10 DSL PF014143 -0.59 PseudoU_synth_1 PF014165 -0.19 ENTH PF014170 100.00 HTH_6 PF014181 -100.00 Jacalin PF014190 100.00 Methylase_S PF014208 -0.07 Reprolysin PF014212 -0.19 zf-NF-X1 PF01422

18 -0.30 LSM PF014235 - R3H PF014247 0.06 Amidase PF014256 0.22 BAH PF01426

14 -0.19 zf-AN1 PF014284 0.04 MBD PF01429

26 -0.67 Peptidase_M13 PF014312 -0.19 Peptidase_M3 PF01432

23 -0.10 Peptidase_M1 PF014333 -0.19 Peptidase_M41 PF014346 -0.88 Peptidase_M48 PF01435

15 - NHL PF0143610 -0.41 PSI PF014372 -100.00 Metallothio_2 PF014391 0.51 Lipoprotein_6 PF01441

11 -0.79 Apolipoprotein PF0144228 -0.81 Viral_helicase1 PF014430 100.00 SH PF014450 100.00 Rep_1 PF014466 -0.37 ELM2 PF014482 -0.19 IlvC PF014506 -1.98 LMWPc PF014512 0.22 Rota_NSP4 PF01452

Sheet1

1 -100.00 B_lectin PF014531 0.51 MAGE PF01454

47 -1.04 Mucin PF014561 0.51 Peptidase_M8 PF014577 -1.03 Porin_3 PF01459

12 -0.11 LRRNT PF014625 -0.70 LRRCT PF01463

13 -2.06 SLT PF014646 -0.59 GRIP PF014659 -2.38 Skp1 PF014665 -0.41 CTP_transf_2 PF014670 100.00 GA PF014682 -0.19 Pentapeptide_2 PF014691 -0.19 Peptidase_C15 PF014702 0.22 PG_binding_1 PF014714 0.22 PUA PF014721 -100.00 CW_binding_1 PF014730 100.00 DAHP_synth_2 PF014741 0.51 FUR PF014756 -0.59 LysM PF014762 -0.88 PLAT PF014774 0.22 S4 PF014794 0.22 PWI PF014803 -0.19 P_proprotein PF014832 0.22 Col_cuticle_N PF01484

22 -0.02 IBR PF014851 0.51 K-box PF014860 100.00 DHquinase_I PF01487

30 -0.45 Shikimate_DH PF0148816 -0.25 Aa_trans PF014901 -0.19 Frataxin_Cyay PF014912 -0.88 Gemini_C4 PF014921 0.91 GXGXG PF01493

28 -0.48 FAD_binding_3 PF0149436 -0.08 V_ATPase_I PF014961 -0.19 Peripla_BP_2 PF014972 2.07 Transposase_5 PF014981 -100.00 Herpes_UL25 PF014990 100.00 Keratin_B2 PF015005 -0.41 Glyco_transf_8 PF015010 100.00 PRA-CH PF015024 -0.88 PIP5K PF015046 -1.29 PAPS_reduct PF015072 -0.88 Paramecium_SA PF015085 -1.80 TruB_N PF01509

12 -1.29 Amidase_2 PF015103 -1.29 Complex1_51K PF015124 -0.88 NAD_kinase PF015131 -100.00 PTA_PTB PF015150 100.00 Orbi_VP6 PF015160 100.00 HDV_ag PF015171 -100.00 PolyG_pol PF015185 -100.00 DUF16 PF015192 0.22 Fe-S_biosyn PF015215 0.15 Polysacc_deac_1 PF015220 100.00 PmbA_TldD PF015231 -100.00 Gemini_V1 PF01524

Sheet1

2 -100.00 Rota_NS26 PF015250 100.00 Transposase_7 PF015266 0.59 Transposase_8 PF015270 100.00 Herpes_glycop PF01528

22 -0.64 zf-DHHC PF015292 0.51 zf-C2HC PF015301 0.51 Glyco_transf_11 PF015315 0.15 Glyco_hydro_47 PF015320 100.00 Tospo_nucleocap PF015337 -0.19 Frizzled PF01534

12 -0.11 PPR PF015351 -0.19 SAM_decarbox PF015360 100.00 Herpes_glycop_D PF015371 -100.00 HCV_NS2 PF015380 100.00 HCV_env PF015392 -100.00 Lipoprotein_7 PF015401 -0.19 GIY-YIG PF015419 -0.19 CorA PF01544

12 -0.88 Cation_efflux PF0154519 -2.03 Peptidase_M20 PF015460 100.00 SBP_bac_1 PF015472 0.22 Transposase_9 PF015480 100.00 ShK PF015491 0.51 Peptidase_M23 PF015512 -100.00 Pico_P2B PF01552

11 -0.19 Acyltransferase PF015534 -0.88 N6_N4_Mtase PF01555

12 -0.88 DnaJ_C PF015564 -0.88 FAA_hydrolase PF015570 100.00 POR PF015580 100.00 HCV_NS1 PF015607 -0.19 Pep_M12B_propep PF015624 -1.57 Spermine_synth PF015645 -1.10 FAD_binding_4 PF015651 0.91 Nramp PF015661 -100.00 Molydop_binding PF01568

11 -0.51 PAP2 PF015690 100.00 Flavi_propep PF015704 -0.19 GCV_T PF015711 0.51 MaoC_dehydratas PF01575

18 -0.19 Myosin_tail_1 PF015761 -0.19 Peptidase_S30 PF015770 100.00 Cytochrom_C_asm PF015781 -100.00 DUF19 PF01579

35 -0.57 FtsK_SpoIIIE PF015802 -0.88 FARP PF01581

11 -0.98 TIR PF0158212 -1.29 APS_kinase PF015830 100.00 CheW PF01584

14 -0.34 G-patch PF015851 -0.19 Basic PF015863 -1.29 tRNA_bind PF015882 0.22 GAF PF015906 0.22 6PF2K PF015912 -0.88 NifU_N PF01592

13 -0.81 Amino_oxidase PF015934 -0.19 UPF0118 PF01594

Sheet1

2 0.22 DUF21 PF015953 -0.19 Methyltransf_3 PF015964 -0.47 GCV_H PF015971 -0.19 Ribosomal_S27 PF015993 -0.59 Corona_S2 PF01601

18 -0.19 Adaptin_N PF016023 0.10 B56 PF016030 100.00 Arteri_env PF01606

93 -0.89 CBM_14 PF016072 0.22 I_LWEQ PF016080 100.00 Transposase_11 PF016090 100.00 Transposase_12 PF016100 100.00 Filo_glycop PF016118 -0.19 3_5_exonuc PF016121 -0.19 Flavin_Reduct PF016131 0.91 Orbi_NS3 PF016162 -100.00 MotA_ExbB PF016181 -0.19 Pro_dh PF016191 -100.00 Pollen_allerg_2 PF016200 100.00 Fusion_gly_K PF016214 -0.88 MutS_I PF016241 -0.19 PMSR PF016250 100.00 Hpt PF016271 0.51 HrcA PF016280 100.00 DUF22 PF016290 100.00 Glyco_hydro_56 PF016301 0.91 Ribosomal_L35p PF01632

46 -1.07 Choline_kinase PF01633154 -0.61 APH PF0163670 -0.28 Arch_ATPase PF016370 100.00 HxlR PF016381 0.51 v110 PF016392 -0.88 SelR PF016411 -100.00 MM_CoA_mutase PF016421 -100.00 Acyl-ACP_TE PF016430 100.00 Chitin_synth_1 PF016444 -1.57 Glu_synthase PF016451 0.51 ACPS PF016481 -0.19 Ribosomal_S20p PF016492 -0.88 Peptidase_C13 PF016508 -1.57 IF4E PF016521 -100.00 Bac_Ubq_Cox PF016541 -0.19 Ribosomal_L32e PF01655

12 -0.19 CbiA PF016563 -0.59 DUF26 PF016572 -0.19 Inos-1-P_synth PF016580 100.00 Vmethyltransf PF016603 -100.00 Macro PF01661

31 -0.91 Phosphodiest PF016630 100.00 Rota_NSP3 PF016651 0.51 DX PF016666 -0.03 Ribosomal_S27e PF016671 -100.00 Glyco_hydro_12 PF016701 -100.00 ASFV_360 PF016711 -0.19 Plasmid_parti PF016721 -100.00 Herpes_env PF016734 0.04 Lipase_2 PF01674

Sheet1

9 -1.00 Metalloenzyme PF016760 100.00 DAP_epimerase PF016780 100.00 SOR_SNZ PF016800 100.00 C6 PF016812 -0.88 DB PF016824 0.73 EB PF016830 100.00 ET PF016841 0.91 Flavokinase PF016875 0.84 Herpes_gI PF016883 0.32 PLRV_ORF5 PF016900 100.00 Adeno_E1B_19K PF01691

10 -1.80 Paramyxo_C PF016923 -0.59 Cauli_VI PF016938 -0.19 Rhomboid PF01694

57 -0.47 IstB PF016951 -0.19 Adeno_E1B_55K PF016967 -0.52 DUF23 PF016977 0.06 FLO_LFY PF016989 0.10 Na_Ca_ex PF016990 100.00 PSI_PsaJ PF017012 0.22 TGT PF017022 -0.19 UDPGP PF017043 -0.19 Gemini_mov PF017084 -0.47 DUF28 PF017093 0.51 Transposase_14 PF017102 0.51 dNK PF017121 -100.00 Smr PF017131 0.91 IPPT PF017151 -100.00 Orbi_NS1 PF017180 100.00 Rep_2 PF01719

24 -0.48 BolA PF017222 -100.00 DUF29 PF017241 -0.19 Ham1p_like PF017251 0.51 LexA_DNA_bind PF01726

18 -0.30 FtsJ PF017281 -0.19 QRPTase_C PF017290 100.00 UreF PF017303 0.10 Arylesterase PF017310 100.00 DUF31 PF017326 -0.37 Nucleoside_tran PF017335 -0.19 Patatin PF017341 -100.00 PLA2_B PF017351 -0.19 Ycf9 PF01737

11 0.05 DLH PF017383 0.10 CheR PF017399 -0.59 STAS PF017400 100.00 MscL PF017410 100.00 Peptidase_M27 PF017422 -100.00 PolyA_pol PF017431 -100.00 GLTT PF017441 0.91 IPT PF017452 -0.19 tRNA_m1G_MT PF017461 0.91 ATP-sulfurylase PF017474 -0.19 IBB PF017490 100.00 HycI PF017503 -0.59 Toprim PF01751

26 -0.19 zf-MYND PF01753

Sheet1

2 -0.19 zf-A20 PF017541 -0.19 Glyco_transf_25 PF017557 -0.75 ACOX PF01756

20 -0.35 Acyl_transf_3 PF017572 -0.19 SBF PF017584 -0.88 NTR PF017591 0.51 DHQ_synthase PF01761

19 -0.83 Galactosyl_T PF017623 -0.59 Herpes_UL6 PF01763

26 -0.35 Lipase_3 PF017642 0.22 RRF PF017650 100.00 Birna_VP2 PF017660 100.00 Birna_VP3 PF017672 -0.19 MgtE PF017697 -0.05 Folate_carrier PF017701 1.20 Herpes_alk_exo PF017712 -0.88 Nucleos_tra2_N PF017730 100.00 UreD PF017743 -1.29 Ribosomal_L18ae PF017752 -0.88 Ribosomal_L22e PF017761 -0.19 Ribosomal_L27e PF017772 -0.88 Ribosomal_L28e PF017781 -100.00 Ribosomal_L29e PF017796 -0.37 Ribosomal_L37ae PF017800 100.00 Ribosomal_L38e PF017810 100.00 RimM PF017823 -1.29 Ribosomal_L32p PF017831 -0.19 NIF3 PF017840 100.00 AOX PF017863 -100.00 PsbJ PF017880 100.00 LGT PF017902 -0.88 DeoC PF017911 -0.19 Glyco_transf_15 PF017932 0.22 Ferric_reduct PF017945 -1.80 Methyltransf_5 PF017950 100.00 DUF35 PF017960 100.00 Transposase_17 PF017973 -0.19 Nop PF017985 -0.19 Fer2_2 PF017996 -1.98 LIM_bind PF018035 -0.70 Surp PF018050 100.00 Paramyxo_P PF018060 100.00 zf-CHC2 PF018071 -0.19 AICARFT_IMPCHas PF018080 100.00 DUF37 PF018090 100.00 LysE PF018101 -0.19 5-FTHF_cyc-lig PF018124 -0.47 ATP-synt_D PF018134 0.04 Hemerythrin PF018141 -0.19 Rop PF018150 100.00 CM_2 PF018170 100.00 Translat_reg PF018180 100.00 Levi_coat PF018192 -100.00 Dala_Dala_lig_N PF018202 0.22 WSC PF018221 -100.00 MACPF PF018231 -100.00 MatK_N PF01824

Sheet1

6 -0.59 GPS PF018257 -0.34 TIL PF018260 100.00 FTH PF018277 -0.19 TIG PF018332 -0.19 XRCC1_N PF018346 -1.29 A2M_N PF018351 -100.00 DUF39 PF018379 -0.44 FG-GAP PF018390 100.00 TCL1_MTCP1 PF018403 0.32 Transglut_core PF018413 0.10 ACT PF018424 -0.88 DIL PF018430 100.00 HNH PF018441 -100.00 CcdB PF018455 -0.41 FF PF018461 -0.19 VHL PF018471 -100.00 HOK_GEF PF018489 -1.69 NAC PF018491 -100.00 PIN PF018505 -0.19 PC_rep PF018514 -0.19 START PF018525 -0.19 MOZ_SAS PF018530 100.00 HP_OMP PF018562 -0.19 RB_B PF018573 -1.29 RB_A PF018583 -1.29 DUF43 PF018610 100.00 DUF45 PF018631 -100.00 DUF46 PF018640 100.00 PhoU_div PF018653 -0.19 Diphthamide_syn PF018660 100.00 Cas_Cas1 PF018671 -0.19 UPF0086 PF018686 -1.29 BcrAD_BadFG PF018691 -0.19 Hjc PF018701 0.51 AMMECR1 PF018714 0.22 eIF-5_eIF-2B PF018731 -0.19 Memo PF018751 1.20 RNase_P_p30 PF018760 100.00 DUF54 PF018770 100.00 DUF55 PF018780 100.00 Cas_Cas6 PF018810 100.00 DUF58 PF018822 -0.88 DUF59 PF018831 -0.19 PcrB PF018841 -0.19 PTS_2-RNA PF018850 100.00 DUF63 PF018891 -100.00 CbiG_C PF018900 100.00 CbiM PF018910 100.00 UPF0058 PF018934 -1.57 UPF0047 PF018945 -0.19 PhoU PF018951 1.20 DNA_primase_S PF018961 -100.00 MNHE PF018992 -0.88 RNase_P_Rpp14 PF019001 0.91 ATP_bind_4 PF019022 -100.00 DUF72 PF019040 100.00 DevR PF01905

Sheet1

1 -0.19 DUF74 PF019063 -0.59 Ribosomal_L37e PF019076 -0.19 NTP_transf_2 PF019090 100.00 DUF77 PF019102 -0.88 eIF-6 PF019120 100.00 FTR PF019130 100.00 Glyco_hydro_3_C PF019151 -0.19 DS PF019160 100.00 Arch_flagellin PF019172 -0.19 Alba PF01918

18 -0.44 Prefoldin_2 PF019204 -0.88 tRNA-synt_1f PF019211 -0.19 SRP19 PF019221 0.91 Cob_adeno_trans PF019231 0.51 HypD PF019244 -1.57 TauE PF01925

46 -0.49 MMR_HSR1 PF019269 -1.00 DUF82 PF019271 -0.19 CYTH PF019281 -0.19 Ribosomal_L14e PF019291 -0.19 Cas_Cas4 PF019300 100.00 NTPase_I-T PF019310 100.00 UPF0052 PF019333 -1.29 DUF86 PF01934

28 -0.48 DUF87 PF019350 100.00 DUF88 PF019365 -1.10 DUF89 PF019372 -0.88 TRAM PF019381 -0.19 DUF92 PF019400 100.00 AdoMet_Synthase PF019410 100.00 Polysacc_synt PF019431 -0.19 DUF95 PF01944

31 -0.22 Thi4 PF019460 100.00 DUF98 PF019470 100.00 PyrI PF019482 -0.88 Archease PF019510 100.00 DUF104 PF01954

10 -0.54 DUF106 PF019568 -0.19 NfeD PF019571 -100.00 DUF108 PF019580 100.00 DHQS PF019590 100.00 ArgJ PF019601 -0.19 TraB PF019630 100.00 ThiC PF019643 -0.19 DJ-1_PfpI PF019655 -1.10 HD PF019661 -100.00 MoaC PF01967

12 -1.06 Hydantoinase_A PF019681 -100.00 DUF111 PF019691 -100.00 TctA PF019701 -0.19 SDH_sah PF019721 -0.19 MAF_flag10 PF019731 0.51 tRNA_int_endo PF019740 100.00 SurE PF019754 0.73 TrmB PF019785 -0.19 Amidohydro_1 PF019794 -100.00 UPF0066 PF01980

Sheet1

3 -0.19 PTH2 PF019811 -100.00 CTP-dep_RFKase PF019820 100.00 CofC PF019832 -100.00 dsDNA_bind PF019841 -100.00 CRS1_YhbY PF019850 100.00 DUF124 PF019876 -1.29 VIT1 PF019882 -100.00 DUF126 PF019893 -1.29 ATP-synt_F PF019903 -1.29 vATP-synt_E PF019912 -0.19 vATP-synt_AC39 PF019921 -100.00 MTD PF019931 -0.19 F420_ligase PF019963 -0.59 Translin PF019970 100.00 DUF131 PF019981 -0.19 DUF134 PF020013 -1.29 TFIIE_alpha PF020021 1.20 TRM PF020050 100.00 MtrH PF020074 -0.47 zf-CXXC PF02008

10 -1.10 Rifin_STEVOR PF020094 -100.00 REJ PF020101 -0.19 BNR PF020127 -0.75 Reeler PF020140 100.00 Glyco_hydro_45 PF020150 100.00 Peptidase_S66 PF020164 -0.19 CIDE-N PF020171 -100.00 CBM_4_9 PF020184 0.22 WIF PF020197 0.17 W2 PF020200 100.00 UPF0102 PF020210 100.00 Integrase_Zn PF020220 100.00 SCAN PF020230 100.00 IL5 PF020251 0.91 RyR PF020261 -100.00 RolB_RolC PF020271 -0.19 Caldesmon PF020290 100.00 Lipoprotein_8 PF020300 100.00 Peptidase_M7 PF020311 -0.19 RBFA PF020332 -0.88 Coagulin PF020355 -0.70 SCP2 PF020366 0.86 SAP PF020370 100.00 ATP1G1_PLM_MAT8 PF020385 -1.80 ArsB PF020401 -0.19 RWP-RK PF020420 100.00 Bac_chlorC PF020432 -0.88 CBFB_NFYA PF020453 -0.19 COX6A PF020461 -100.00 FliE PF020493 -100.00 FliJ PF020502 -0.19 Glyco_hydro_30 PF020552 -0.19 Glyco_hydro_4 PF020560 100.00 Glyco_hydro_59 PF020572 -100.00 Guanylin PF020580 100.00 ISK_Channel PF020600 100.00 Lambda_CIII PF02061

Sheet1

0 100.00 MARCKS PF020634 -0.47 MAS20 PF020643 -1.29 Melibiase PF020651 -100.00 Metallothio_11 PF020664 -100.00 Metallothio_5 PF020671 -100.00 Metallothio_PEC PF020682 -0.88 Metallothio_Pro PF020690 100.00 NMU PF020701 -0.19 NSF PF020711 -100.00 Orexin PF020720 100.00 Peptidase_M29 PF020732 -100.00 RuvC PF020750 100.00 STE3 PF020763 -1.29 SURF4 PF020772 -100.00 Synapsin PF020782 -100.00 TP1 PF020791 -0.19 TrkA_C PF020800 100.00 TrpBP PF020810 100.00 Rrf2 PF020821 -100.00 Bindin PF020840 100.00 Cytochrom_CIII PF020853 -1.29 MethyltransfD12 PF020862 -100.00 Nitrophorin PF020872 -0.19 Palm_thioest PF020890 100.00 SPAM PF020900 100.00 tRNA-synt_2e PF020910 100.00 tRNA_synt_2f PF020921 -100.00 Gag_p30 PF020936 -0.19 60KD_IMP PF020961 0.91 Filo_VP35 PF020970 100.00 His_binding PF020981 0.51 Josephin PF020993 -0.19 ODC_AZ PF021000 100.00 Ocular_alb PF021011 0.91 SURF1 PF021040 100.00 Fanconi_C PF021060 100.00 FlgH PF021071 0.91 FliH PF021081 -0.19 DAD PF021094 -100.00 HK PF021100 100.00 PDEase_II PF021120 100.00 Peptidase_S13 PF021133 -0.19 Phosducin PF021142 -0.88 Rho_GDI PF021151 0.51 Srg PF021180 100.00 FlgI PF021190 100.00 Flg_hook PF021203 0.32 IP_trans PF021211 -0.19 Peptidase_S39 PF021221 -100.00 RdRP_4 PF021235 -1.10 Marek_A PF021241 0.51 PTE PF021260 100.00 Peptidase_M18 PF021278 -0.66 Peptidase_S15 PF021291 -100.00 UPF0054 PF021304 0.04 RecR PF021324 -0.88 UBACT PF02134

Sheet1

3 0.10 zf-TAZ PF021356 -0.59 NTF2 PF021361 0.51 A_deamin PF021376 -0.03 Beach PF021381 0.91 Gal_Lectin PF021405 0.15 DENN PF021412 -0.88 MGS PF021423 -100.00 Rad1 PF021444 0.22 Rap_GAP PF021456 -0.03 SIR2 PF021468 0.30 zf-UBP PF021481 0.51 KA1 PF021497 0.17 RNA_POL_M_15KD PF021501 0.51 UVR PF021511 -100.00 FolB PF021525 -100.00 PDH PF021530 100.00 FliM PF021540 100.00 GCR PF021550 100.00 Glyco_hydro_26 PF021561 -0.19 Man-6-P_recep PF021570 100.00 Neuregulin PF021580 100.00 Oest_recep PF021590 100.00 Prog_receptor PF021611 0.51 Peptidase_M50 PF021631 -100.00 WT1 PF021650 100.00 Androgen_recep PF021663 -0.59 Cytochrom_C1 PF021670 100.00 LPP20 PF021696 -0.19 PAZ PF021704 0.22 Piwi PF021712 -0.19 KIX PF021722 -100.00 pKID PF021734 0.04 IRS PF021741 0.51 7TM_GPCR_Srb PF021759 0.01 zf-TRAF PF021761 -0.19 A4_EXTRA PF02177

13 -0.96 AT_hook PF021781 0.51 BAG PF021796 -0.03 FH2 PF021810 100.00 YDG_SRA PF02182

25 -0.27 HALZ PF021831 0.51 HAT PF021846 -0.03 HR1 PF021853 0.10 TFIIE_beta PF021862 -0.19 GAS2 PF021871 0.91 GoLoco PF021880 100.00 ITAM PF021893 0.32 LON PF021903 -0.59 OLF PF021912 0.22 PI3K_p85B PF021922 0.51 PXA PF021942 -0.88 ParBc PF021954 -0.19 RBD PF021967 -1.03 RIIa PF02197

18 -0.44 SAM_PNT PF021980 100.00 SapA PF021990 100.00 STE PF02200

Sheet1

2 0.73 SWIB PF022011 -0.19 Tachykinin PF022023 -0.59 TarH PF022034 0.04 VPS9 PF022047 -0.34 WH2 PF022051 -100.00 WSN PF022066 -0.19 zf-UBR PF022070 100.00 Sorb PF022083 -0.19 VHP PF02209

20 0.19 Laminin_G_2 PF022100 100.00 NHase_beta PF022113 0.32 GED PF022122 -0.19 GYF PF02213

13 -0.45 K_tetra PF022140 100.00 T_Ag_DNA_bind PF022171 -100.00 HS1_rep PF022181 -0.19 MTHFR PF022199 -0.77 E1_DerP2_DerF2 PF022216 -0.37 ATP-grasp PF02222

13 -0.81 Thymidylate_kin PF022231 -100.00 Cytidylate_kin PF022243 -0.59 PA PF022250 100.00 Pico_P1A PF022260 100.00 Gag_p19 PF022281 -0.19 PC4 PF02229

19 -0.42 Abhydrolase_2 PF022300 100.00 PNTB PF022331 0.91 CDI PF022341 0.51 BPL_C PF022372 -0.88 COX7a PF02238

13 -0.11 Cytochrom_D1 PF022391 -100.00 MCR_gamma PF02240

16 -1.17 Propep_M14 PF022440 100.00 Pur_DNA_glyco PF022451 -100.00 Como_LCP PF022470 100.00 Como_SCP PF022480 100.00 MCR_alpha PF022491 -100.00 Orthopox_35kD PF022501 0.91 PA28_alpha PF022512 -0.88 PA28_beta PF02252

13 0.54 TrkA_N PF022540 100.00 PTS_IIA PF022551 -0.19 Fe_hyd_SSU PF022563 0.10 RFX_DNA_binding PF022571 -100.00 SLT_beta PF022588 -0.19 FAT PF022599 -1.00 FATC PF022600 100.00 Asp_decarbox PF022612 -0.88 Cbl_N PF022623 -0.59 GBP PF022630 100.00 S1-P1_nuclease PF022653 -1.29 TFIIA_gamma_N PF022682 -0.19 TFIID-18kDa PF022691 -0.19 TFIIF_beta PF022702 -0.88 UCR_14kD PF022711 0.91 DHHA1 PF022720 100.00 Acyl_transf_2 PF02273

Sheet1

1 0.91 Amidinotransf PF022740 100.00 CytoC_RC PF022760 100.00 DBI_PRT PF022770 100.00 Transposase_Tn5 PF022810 100.00 CobU PF022831 -0.19 COX5A PF022841 -0.19 COX8 PF022850 100.00 Dehydratase_SU PF022870 100.00 MCH PF022891 -0.19 SRP14 PF02290

27 -2.79 TFIID-31kDa PF022910 100.00 AmiS_UreI PF022930 100.00 z-alpha PF022951 -0.19 Alpha_adaptin_C PF022963 0.51 COX6B PF022970 100.00 Cu_bind_like PF022980 100.00 Fumarate_red_C PF023002 -0.19 HORMA PF023011 -100.00 PTS_IIB PF023020 100.00 Phage_DNA_bind PF023031 -0.19 Phage_B PF023040 100.00 MgtC PF023089 -1.00 AUX_IAA PF023091 0.51 B12-binding PF023101 -0.19 AraC_binding PF023112 -0.88 CBF_beta PF023120 100.00 Fumarate_red_D PF023130 100.00 Mu_DNA_bind PF023164 -0.19 Octopine_DH PF023171 0.91 RPH3A_effect_N PF023184 -0.19 E2F_TDP PF023195 -0.70 UCR_hinge PF023202 0.51 OEP PF023211 -100.00 Cyto_ox_2 PF023222 -100.00 ELH PF023230 100.00 YGGT PF023250 100.00 YMF19 PF023260 100.00 BChl_A PF023270 100.00 HDC PF023291 -0.19 MAM33 PF023302 -100.00 P35 PF023310 100.00 RTP PF023340 100.00 Denso_VP4 PF023360 100.00 Gag_p10 PF023378 -0.32 OTU PF023381 -100.00 RcbX PF023412 -100.00 TerD PF023420 100.00 TRA-1_regulated PF023430 100.00 Myc-LZ PF023447 -0.75 Vac_Fusion PF023462 -0.88 GDC-P PF023471 -0.19 CTP_transf_3 PF023481 0.51 MSG PF023490 100.00 Epimerase_2 PF023501 0.91 GDNF PF023510 100.00 Decorin_bind PF02352

12 -0.19 CMAS PF02353

Sheet1

0 100.00 Latrophilin PF023540 100.00 SecD_SecF PF023550 100.00 NusG PF023573 -1.29 Trehalose_PPase PF023583 -1.29 CDC48_N PF023590 100.00 CbiQ PF023618 -1.57 C_tripleX PF023630 100.00 Glucan_synthase PF023640 100.00 NAM PF023652 -0.19 PMT PF02366

37 -0.50 UPF0079 PF023671 0.51 Big_2 PF023683 -0.19 Big_1 PF023690 100.00 M PF023701 -0.19 Transposase_20 PF023711 -100.00 IL15 PF02372

13 -0.45 JmjC PF023735 0.28 ArsA_ATPase PF023745 -1.10 JmjN PF023751 1.20 CUT PF023764 -0.88 Dishevelled PF023771 -100.00 Papo_T_antigen PF023800 100.00 MraZ PF023811 -100.00 RTX PF023824 -0.19 Syja_N PF023833 0.10 N6_Mtase PF023841 -100.00 TrkH PF023861 -100.00 IncFII_repA PF023874 -0.47 FemAB PF023883 -0.19 Cornifin PF02389

17 -0.31 Methyltransf_4 PF023901 -100.00 MoaE PF023910 100.00 Ycf4 PF023920 100.00 US22 PF023931 0.51 IL1_propep PF023942 0.22 Peptidase_S6 PF023951 -100.00 Herpes_ori_bp PF023990 100.00 Lysis_col PF02402

13 0.54 Seryl_tRNA_N PF024030 100.00 SCF PF024040 100.00 DUF140 PF024050 100.00 MmoB_DmpM PF024061 -100.00 Viral_Rep PF024078 -1.17 CUB_2 PF024081 -0.19 DUF143 PF024100 100.00 MerT PF02411

10 -1.39 TSP_3 PF024122 -100.00 Caudo_TAP PF024131 -100.00 Chlam_PMP PF024151 -100.00 MttA_Hcf106 PF024161 -100.00 Chromate_transp PF024171 -100.00 PsbL PF02419

45 -0.28 FeoB_N PF024211 -100.00 Keratin PF024223 -1.29 OCD_Mu_crystall PF024231 -100.00 GBP_PSP PF024250 100.00 MIase PF02426

Sheet1

0 100.00 PSI_PsaE PF024270 100.00 PCP PF024291 -100.00 AMA-1 PF024300 100.00 FixO PF02433

19 -0.83 Fringe PF024341 -100.00 Glyco_hydro_68 PF024351 -0.19 PYC_OADA PF024363 -0.19 Ski_Sno PF024379 0.10 Adeno_E3_CR2 PF024391 0.91 Adeno_E3_CR1 PF024401 -0.19 Flavoprotein PF024410 100.00 L1R_F9L PF024421 -0.19 Circo_capsid PF024431 -100.00 NadA PF024450 100.00 Glyco_hydro_77 PF02446

10 -2.49 L71 PF024482 -0.88 Glyco_hydro_42 PF024494 0.51 LACT PF024500 100.00 Nodulin PF024510 100.00 PemK PF024525 -0.70 Reticulon PF024531 -100.00 Sigma_1s PF024543 -1.29 Hex_IIIa PF024559 -100.00 Adeno_IVa2 PF024560 100.00 DisA_N PF024570 100.00 Transferase PF024580 100.00 Adeno_terminal PF024598 0.13 Patched PF024600 100.00 AMO PF02461

62 -0.51 SMC_N PF024630 100.00 CinA PF024645 -0.41 FliD_N PF02465

10 -0.54 Tim17 PF024660 100.00 PsbN PF024684 -0.19 Fasciclin PF024690 100.00 MCE PF024700 100.00 OspE PF024711 -0.19 ExbD PF024720 100.00 NodA PF02474

12 -0.37 Met_10 PF024750 100.00 US2 PF024760 100.00 Pneumo_phosprot PF024780 100.00 Herpes_IE68 PF02479

28 -0.15 Herpes_gE PF024800 100.00 DNA_processg_A PF024811 -0.19 Ribosomal_S30AE PF024821 0.51 Branch PF024850 100.00 Rep_trans PF024861 -0.19 CLN3 PF024870 100.00 EMA PF024880 100.00 Herpes_glycop_H PF02489

13 -0.81 FtsA PF0249140 -0.51 cobW PF024929 -0.59 MORN PF024933 0.10 HYR PF024941 -0.19 7kD_coat PF024951 -100.00 ABA_WDS PF02496

Sheet1

0 100.00 Bro-N PF024981 -100.00 LacAB_rpiB PF025020 100.00 FA_synthesis PF025040 100.00 MCR_D PF025051 -100.00 PSI_PsaF PF025070 100.00 Rota_NS35 PF025091 -100.00 SPAN PF025101 -100.00 Thy1 PF025113 -100.00 Spin-Ssty PF025131 -0.19 CobN-Mg_chel PF025142 -0.19 CoA_transf_3 PF025152 -0.88 STT3 PF025162 -0.88 Abi PF025179 -0.19 HATPase_c PF025181 -0.19 Auxin_inducible PF025194 0.22 DUF148 PF025200 100.00 HP_OMP_2 PF025210 100.00 Antibiotic_NAT PF025221 -100.00 KID PF025240 100.00 Flavodoxin_2 PF025250 100.00 GBP_repeat PF025263 0.10 GidB PF025271 -100.00 PetG PF025291 -0.19 PsaD PF025310 100.00 PsbK PF025330 100.00 TraG PF02534

69 -0.47 Zip PF025355 -1.80 mTERF PF025361 -100.00 CRCB PF025371 -0.19 Hydantoinase_B PF025384 -0.47 NAD_synthase PF025401 -100.00 Ppx-GppA PF025411 0.51 YgbB PF025423 -0.19 Steroid_dh PF025441 0.51 Maf PF025450 100.00 Queuosine_synth PF025471 -0.19 AcetylCoA_hydro PF025501 -100.00 Acyl_CoA_thio PF025511 -0.19 CO_dh PF025520 100.00 CbiN PF025531 -100.00 CstA PF025540 100.00 SecB PF02556

12 -0.73 ApbA PF025580 100.00 CarD_TRCF PF025590 100.00 FliS PF02561

42 -0.34 PhoH PF025621 0.91 Poly_export PF025630 100.00 RecO_C PF025650 100.00 OsmC PF025660 100.00 PhzC-PhzF PF025672 -0.88 ThiI PF025681 -0.19 Pantoate_ligase PF025690 100.00 CbiC PF025700 100.00 CbiJ PF025710 100.00 CobA_CobO_BtuR PF025722 -0.19 S-methyl_trans PF025741 -100.00 DUF149 PF02575

Sheet1

0 100.00 DUF150 PF025761 -100.00 Cu-oxidase_4 PF025781 -0.19 Tyr_Deacylase PF025802 -0.88 TMP-TENI PF025811 0.51 DUF155 PF025821 -0.19 DUF156 PF025831 -100.00 PIG-L PF025851 -100.00 DUF159 PF025860 100.00 DUF162 PF025891 -100.00 SPOUT_MTase PF025901 2.01 DUF164 PF025910 100.00 DUF165 PF025920 100.00 DUF166 PF025931 -0.19 DUF167 PF025940 100.00 Gly_kinase PF025950 100.00 DUF169 PF025961 0.91 ThiS PF025971 -0.19 DUF171 PF025980 100.00 CsrA PF02599

12 -0.59 Exonuc_VII_L PF026013 -1.29 HEM4 PF026020 100.00 Hpr_kinase_N PF026030 100.00 PhdYeFM PF026040 100.00 PsaL PF026051 -100.00 LpxK PF026062 -100.00 B12-binding_2 PF026070 100.00 Exonuc_VII_S PF026090 100.00 Arabinose_Isome PF026100 100.00 CDH PF026113 -1.29 Ldh_2 PF026150 100.00 ScpA_ScpB PF026161 -0.19 ClpS PF026170 100.00 YceG PF026182 -0.88 DUF177 PF026200 100.00 FliW PF026231 -100.00 YcaO PF026241 -100.00 XdhC_CoxI PF026250 100.00 AHS2 PF026263 -0.59 CMD PF026271 -0.19 COX15-CtaA PF026284 -0.47 CoA_binding PF026293 -0.19 SCO1-SenC PF026300 100.00 RecX PF026310 100.00 BioY PF026321 -100.00 DrsE PF026355 -0.70 DUF185 PF026363 -0.59 GatB_Yqey PF026370 100.00 DUF187 PF026381 -0.19 DUF188 PF026390 100.00 DUF190 PF026411 -100.00 DUF192 PF026434 0.04 RmuC PF026460 100.00 HTH_WhiA PF026501 0.91 BPD_transp_2 PF026537 -0.19 ATP-grasp_3 PF026552 0.51 DUF202 PF026561 -100.00 SufE PF02657

Sheet1

1 -100.00 DUF204 PF026591 -0.19 Fic PF026610 100.00 FlpD PF026620 100.00 FmdE PF026630 100.00 LuxS PF026641 -100.00 Nitrate_red_gam PF026652 -0.88 PS_Dcarbxylase PF026660 100.00 SCFA_trans PF026674 -1.57 TauD PF026680 100.00 KdpC PF026690 100.00 DXP_reductoisom PF026702 0.51 PAH PF026710 100.00 CP12 PF026722 -100.00 Colicin_V PF026740 100.00 DUF208 PF026771 -100.00 ComA PF026790 100.00 DUF211 PF026800 100.00 AHS1 PF026820 100.00 LpxB PF026841 0.51 Glu-tRNAGln PF026863 -1.29 FtsX PF026871 -0.19 Herpes_Helicase PF026890 100.00 Na_Pi_cotrans PF026901 -100.00 VacA PF026910 100.00 UPF0060 PF026941 -100.00 UPF0061 PF026960 100.00 DUF217 PF026971 -100.00 DUF218 PF026984 -0.88 YajC PF026990 100.00 PurS PF027001 -100.00 zf-Dof PF027010 100.00 KdpD PF027020 100.00 Adeno_E1A PF027031 -100.00 GASA PF027044 0.51 K_trans PF027051 -0.19 Wzz PF027067 -0.19 Galactosyl_T_2 PF027093 -1.29 Pap_E4 PF027111 -0.19 DUF221 PF027140 100.00 Herpes_UL31 PF02718

32 -0.01 Polysacc_synt_2 PF027190 100.00 DUF222 PF027202 0.22 DUF223 PF027210 100.00 NS3_envE PF02723

56 -0.55 CDC45 PF027240 100.00 Paramyxo_NS_C PF027250 100.00 OTCace_N PF027290 100.00 AFOR_N PF027301 -0.19 SKIP_SNW PF027314 -0.47 ERCC4 PF027321 0.91 Dak1 PF027330 100.00 Dak2 PF027342 0.22 Ku PF027353 -0.59 Myosin_N PF02736

17 0.02 3HCDH_N PF027375 -0.19 Ald_Xan_dh_C2 PF027380 100.00 5_3_exonuc_N PF02739

Sheet1

0 100.00 FTR_C PF027410 100.00 Fe_dep_repr_C PF027424 0.04 Cache_1 PF027431 -0.19 GalP_UDP_tr_C PF027440 100.00 MCR_alpha_N PF027450 100.00 MR_MLE_N PF027463 -1.29 PCNA_C PF02747

25 -0.32 PyrI_C PF027480 100.00 QRPTase_N PF027491 -0.19 Synapsin_C PF027502 -0.88 TFIIA_gamma_C PF02751

17 -1.92 Arrestin_C PF027521 0.51 CCG PF027542 0.22 RPEL PF02755

12 -100.00 GYR PF0275619 -100.00 YLP PF027571 -100.00 PAAD_DAPIN PF027588 -0.47 RUN PF027591 0.51 Cbl_N2 PF027611 0.51 Cbl_N3 PF027620 100.00 Diphtheria_T PF027640 100.00 Telo_bind PF027651 -100.00 DNA_pol3_beta_2 PF027673 0.10 AIRS_C PF02769

14 -0.43 Acyl-CoA_dh_M PF027709 -0.30 Acyl-CoA_dh_N PF027712 -0.19 S-AdoMet_synt_M PF027721 -100.00 S-AdoMet_synt_C PF027730 100.00 Semialdhyde_dhC PF027744 -0.47 TPP_enzyme_C PF027751 -0.19 TPP_enzyme_N PF027761 0.51 Sod_Fe_C PF027771 0.51 tRNA_int_endo_N PF027786 -0.19 Transket_pyr PF027793 -0.59 Transketolase_C PF027802 -0.88 G6PD_C PF02781

15 -0.70 FGGY_C PF027822 0.51 Orn_Arg_deC_N PF027843 0.10 Biotin_carb_C PF027855 -0.19 CPSase_L_D2 PF027861 -0.19 CPSase_L_D3 PF027872 -0.88 RuBisCO_large_N PF027888 -2.27 Peptidase_M17_N PF027891 0.91 COX2_TM PF027903 -0.19 DDT PF027911 -0.19 Mago_nashi PF02792

10 -0.29 HRM PF027931 -0.19 HlyC PF027944 0.62 HTH_7 PF027960 100.00 Chal_sti_synt_C PF02797

40 -0.83 GST_N PF027981 0.51 NMT_C PF027993 -1.29 Gp_dh_C PF028006 1.39 Ketoacyl-synt_C PF028017 -0.75 Thiolase_C PF028031 -100.00 Ada_Zn_binding PF028054 -0.47 Alpha-amylase_C PF02806

Sheet1

4 -0.47 ATP-gua_PtransN PF028077 -0.19 UIM PF028092 -0.19 ELFV_dehydrog_N PF028126 -0.59 MIR PF028150 100.00 Alpha_kinase PF028163 -0.19 E3_binding PF028171 -100.00 PPAK PF028183 0.10 MBT PF028200 100.00 Staphylokinase PF028212 0.22 Antistasin PF028221 -0.19 ATP-synt_DE_N PF028237 -0.75 TGS PF028245 -0.19 WWE PF02825

34 -0.54 2-Hacid_dh_C PF028260 100.00 PKI PF028276 -0.88 L27 PF028281 -0.19 3H PF028291 -100.00 gpW PF028311 -0.19 DHHA2 PF028332 -0.19 2_5_RNA_ligase PF028342 -0.19 Glyco_hydro_2_C PF028364 -0.88 Glyco_hydro_2_N PF028373 0.10 Glyco_hydro_20b PF028381 -100.00 CBM_5_12 PF028392 -0.88 Prp18 PF028402 0.22 GBP_C PF028411 -0.19 GARS_C PF028432 0.22 GARS_N PF028448 -0.32 CUE PF028457 -1.44 MA3 PF028473 0.10 Pyr_redox_dim PF02852

12 -0.88 MIF4G PF028540 100.00 Clp_N PF02861

24 -1.06 DDHD PF028622 -100.00 Arg_repressor_C PF028631 -0.19 STAT_bind PF028642 0.22 STAT_int PF028656 -0.19 Ldh_1_C PF028661 0.51 Ribonuc_red_lgC PF028672 -100.00 Peptidase_M4_C PF028686 -1.29 5_nucleotid_C PF028721 -100.00 MurB_C PF028737 -1.03 ATP-synt_ab_N PF028742 -100.00 Mur_ligase_C PF028751 -100.00 Stap_Strp_tox_C PF028760 100.00 PARP_reg PF028774 -0.47 PGM_PMM_I PF028784 -0.19 PGM_PMM_II PF028794 -0.47 PGM_PMM_III PF028802 -0.19 SRP54_N PF02881

13 -0.27 THF_DHG_CYH_C PF028825 -0.19 Alpha_adaptinC2 PF028831 0.51 Lyase_8_C PF028842 -0.88 Glycos_trans_3N PF028858 -1.17 PK_C PF028871 -100.00 CaMBD PF028883 0.10 Sec63 PF02889

Sheet1

1 -100.00 DUF226 PF0289016 -0.47 zf-MIZ PF0289155 0.15 zf-BED PF028927 0.06 GRAM PF028932 -0.88 GFO_IDH_MocA_C PF028942 -0.88 H-kinase_dim PF028954 -0.88 Peptidase_S9_N PF028971 -0.19 NO_synthase PF028981 1.89 Phage_integr_N PF028990 100.00 LigB PF029000 100.00 PFL PF029017 -0.19 Peptidase_C48 PF029021 -100.00 EBV-NA1 PF029050 100.00 Fe_hyd_lg_C PF029060 100.00 Peptidase_S29 PF029072 -100.00 TetR_C PF029093 -0.59 Succ_DH_flav_C PF029102 -0.88 Formyl_trans_C PF029113 0.10 Phe_tRNA-synt_N PF029122 0.51 FAD-oxidase_C PF029133 -0.59 Rubrerythrin PF029150 100.00 Pertussis_S2S3 PF029183 -1.29 Topoisom_I_N PF029190 100.00 Integrase_DNA PF029202 -100.00 UCR_TM PF029211 -0.19 CBM_48 PF029221 -100.00 gpD PF029252 -0.19 THUMP PF029260 100.00 CelD_N PF029272 -0.88 zf-C5HC2 PF02928

22 0.02 Neur_chan_LBD PF0293147 -0.43 Neur_chan_memb PF029324 -0.19 CDC48_2 PF029331 -0.19 GatB_N PF029341 0.91 COX7C PF029352 -0.88 COX4 PF029362 -0.88 COX6C PF029373 -1.29 GAD PF029381 -0.19 UcrQ PF029390 100.00 mRNA_triPase PF029400 100.00 FeThRed_A PF029411 -100.00 Flu_B_NS1 PF02942

20 -1.57 BESS PF029442 0.51 Endonuclease_7 PF029450 100.00 Flt3_lig PF029470 100.00 Amelogenin PF02948

61 0.75 7tm_6 PF029496 -1.29 Conotoxin PF029507 -0.52 zf-Tim10_DDP PF029535 -0.41 HTH_8 PF029541 0.51 TT_ORF1 PF029561 -0.19 TT_ORF2 PF02957

56 -1.12 DUF227 PF029580 100.00 Tax PF029590 100.00 K1 PF029601 -0.19 BAF PF029611 -100.00 MeMO_Hyd_G PF02964

Sheet1

0 100.00 Met_synt_B12 PF029654 -0.88 DIM1 PF02966

28 -1.73 TAF PF029696 -1.29 TBCA PF029701 -0.19 Sialidase PF029730 100.00 Me-amine-dh_L PF029751 0.51 CarbpepA_inh PF029772 -0.88 SRP_SPB PF029780 100.00 FokI_N PF029810 100.00 Scytalone_dh PF029821 -100.00 Pro_Al_protease PF02983

13 -0.19 Cyclin_C PF0298462 0.12 HEAT PF029850 100.00 Fn_bind PF029861 -100.00 LEA_4 PF029871 -100.00 PLA2_inh PF029880 100.00 DUF228 PF029893 -0.19 EMP70 PF029902 -0.88 MAP1_LC3 PF029910 100.00 Transposase_21 PF029924 -0.88 MCPVI PF029934 -1.57 Transposase_22 PF02994

22 -1.49 DUF229 PF0299510 0.08 Prefoldin PF029962 -100.00 Lentiviral_Tat PF029980 100.00 Borrelia_orfD PF029990 100.00 Transposase_24 PF030041 -100.00 DUF231 PF030054 0.04 HlyIII PF030061 0.91 UPF0089 PF030071 -0.19 DUF234 PF030089 -1.69 GDPD PF030091 -100.00 PFEMP PF030110 100.00 Pyr_excise PF030130 100.00 SP2 PF03014

16 0.22 Sterile PF030153 -0.19 Exostosin PF030160 100.00 Transposase_23 PF030175 -0.41 LEM PF030200 100.00 CM2 PF03021

14 -0.12 MRJP PF030220 100.00 MVIN PF030230 100.00 Folate_rec PF030241 -100.00 Papilloma_E5 PF030250 100.00 CM1 PF030269 0.84 Dynein_heavy PF03028

33 -0.32 ATP_bind_1 PF0302910 -0.70 NIF PF030313 -100.00 Brevenin PF030323 -1.29 Glyco_transf_28 PF030331 -0.19 PSS PF030340 100.00 RNA_capsid PF030353 -0.59 Perilipin PF030363 -100.00 KMP11 PF030371 -100.00 CemA PF030400 100.00 Baculo_LEF-2 PF030415 -1.80 Herpes_UL87 PF03043

Sheet1

1 0.51 DAN PF030450 100.00 ComC PF030470 100.00 Herpes_UL92 PF030480 100.00 Herpes_UL79 PF030490 100.00 Transposase_25 PF03050

12 -0.88 Peptidase_C1_2 PF030510 100.00 Adeno_52K PF030526 -0.59 tRNA_Me_trans PF030542 -0.88 RPE65 PF030551 -100.00 DUF236 PF030572 -100.00 Sar8_2 PF030581 -100.00 NAS PF030593 -0.19 NPD PF030606 -0.88 4HBT PF030617 0.27 MBOAT PF030620 100.00 Prismane PF030636 -0.59 U79_P34 PF03064

29 -1.07 Nucleoplasmin PF030663 0.10 Chitin_bind_3 PF030671 -100.00 PAD PF030680 100.00 TENA_THI-4 PF030703 -0.59 GNT-I PF030710 100.00 DUF237 PF030721 -100.00 TspO_MBR PF030731 0.91 GCS PF030741 -100.00 GP3 PF030761 -100.00 ATHILA PF030782 0.51 ARD PF030791 -0.19 Exo70 PF030811 -0.19 MAGSP PF030826 -0.88 MtN3_slv PF030830 100.00 RAP-1 PF030850 100.00 DUF240 PF030862 -0.19 DUF241 PF030874 -0.88 Str_synth PF030880 100.00 RAG2 PF030892 -0.19 CutA1 PF030914 -0.88 BT1 PF030921 0.91 Mlo PF030943 0.32 PTPA PF030959 -0.59 Ndr PF030963 0.32 BRO1 PF03097

10 0.22 An_peroxidase PF030984 -0.47 BPL_LplA_LipB PF030990 100.00 CcmE PF031001 -0.19 FAR1 PF031012 -100.00 NeuB PF03102

27 -2.39 DUF243 PF031034 -0.19 DNA_pol_B_exo PF031049 -1.00 SPX PF031058 0.04 C1_2 PF031075 -0.19 ABC1 PF031090 100.00 SBP PF031100 100.00 DUF244 PF031127 0.35 BAR PF031142 0.51 Astro_capsid PF031150 100.00 Herpes_UL49_1 PF03117

Sheet1

1 -100.00 RNA_pol_A_CTD PF031182 -100.00 DNA_ligase_ZBD PF031191 -100.00 DNA_ligase_OB PF031200 100.00 Herpes_UL52 PF031211 -100.00 Herpes_MCP PF031220 100.00 CAT_RBD PF031234 -0.47 EXS PF031241 -100.00 Sre PF031255 -1.80 Plus-3 PF031263 -0.59 GAT PF031270 100.00 CXCXC PF031287 -0.52 HGTP_anticodon PF03129

10 -0.54 HEAT_PBS PF0313012 -0.59 bZIP_Maf PF0313111 -0.10 TTL PF031336 -0.88 TB2_DP1_HVA22 PF031340 100.00 CagE_TrbE_VirB PF03135

18 -0.24 OATP PF031371 0.51 AnfG_VnfG PF031391 -100.00 DUF248 PF031413 -1.29 Chitin_synth_2 PF031428 -0.47 GTP_EFTU_D3 PF03143

17 -0.46 GTP_EFTU_D2 PF031447 -0.34 Sina PF031451 0.51 FDX-ACB PF031476 0.10 Tektin PF031481 -0.19 CCP_MauG PF03150

10 - TPT PF031511 -0.19 UFD1 PF03152

66 -1.08 TFIIA PF0315310 0.28 Atrophin-1 PF031542 -0.19 Alg6_Alg8 PF031552 -0.88 DUF249 PF031585 -1.10 XRN_N PF031591 -0.19 Calx-beta PF031606 -0.37 Y_phosphatase2 PF031622 -0.88 01/06/10 PF031646 -0.19 MH1 PF031656 -0.37 MH2 PF031663 0.10 UDG PF031670 100.00 LEA_2 PF031682 -0.19 OPT PF03169

26 -1.14 2OG-FeII_Oxy PF031711 -0.19 Sp100 PF031720 100.00 CHB_HEX PF031730 100.00 CHB_HEX_C PF031741 -0.19 DNA_pol_B_2 PF031753 0.66 MMPL PF031762 -0.88 Nucleoporin_C PF031778 -0.47 CPSF_A PF031781 0.51 V-ATPase_G PF031790 100.00 Lipoprotein_9 PF031800 100.00 BURP PF031810 100.00 Borrelia_rep PF031830 100.00 DDE PF031844 -0.88 CaKB PF031853 -100.00 CobD_Cbib PF03186

Sheet1

0 100.00 Corona_I PF031878 -0.88 Cytochrom_B561 PF03188

18 -0.37 Otopetrin PF031892 0.22 DUF255 PF031900 100.00 DUF257 PF03192

118 -0.57 DUF258 PF031935 -1.10 LUC7 PF031940 100.00 DUF260 PF031951 -100.00 DUF261 PF031961 -100.00 Glyco_hydro_72 PF031982 0.22 GSH_synthase PF031991 -100.00 Glyco_hydro_63 PF032001 -0.19 HMD PF032010 100.00 Lipoprotein_10 PF032020 100.00 MerC PF03203

69 -0.69 MobB PF032052 -0.88 NifW PF032061 -0.19 OspD PF032072 0.73 PRA1 PF032084 -0.19 PUCC PF032090 100.00 Paramyx_P_V PF032100 100.00 Pectate_lyase PF032110 100.00 Pox_P35 PF032130 100.00 RGP PF03214

32 -0.40 Rad17 PF032150 100.00 Rhabdo_ncap_2 PF032161 -0.19 TLC PF032191 -100.00 Tombus_P19 PF032205 0.91 Transposase_Tc5 PF032212 0.22 Trp_Tyr_perm PF032222 -0.88 V-ATPase_C PF032235 -0.41 V-ATPase_H_N PF032243 -0.59 Yippee PF032264 -0.88 GILT PF032270 100.00 Adeno_VII PF032284 -100.00 Alpha_GJ PF032290 100.00 Antirestrict PF032301 1.20 COQ7 PF032323 0.10 Cauli_AT PF032334 -0.88 CDC37_N PF032340 100.00 DUF262 PF032350 100.00 Terminase_6 PF032370 100.00 ESAG1 PF032381 -0.19 FTR1 PF032390 100.00 LEA_3 PF032423 0.32 Phage_lysis PF032451 -0.19 Prothymosin PF032471 -0.19 Rer1 PF032485 0.15 TSA PF032491 -0.19 Tropomodulin PF032501 -100.00 Herpes_UL21 PF032520 100.00 UT PF032531 -100.00 XG_FTase PF032542 -0.19 ACCA PF032553 -0.59 APC10 PF032560 100.00 Baculo_FP PF03258

13 -1.65 Robl_LC7 PF03259

Sheet1

4 0.22 CDK5_activator PF032610 100.00 Cucumo_2B PF032631 -0.19 Cytochrom_NNT PF032641 -100.00 DNase_II PF03265

31 -0.63 DUF265 PF032664 -0.88 EB1 PF032710 100.00 Enhancin PF032720 100.00 Baculo_gp64 PF032730 100.00 Foamy_BEL PF032745 -0.41 Gag_spuma PF032761 -100.00 Herpes_UL4 PF032770 100.00 IpaB_EvcA PF032781 -100.00 Lipase_chap PF032805 -0.70 Mab-21 PF032811 -0.19 PAE PF032830 100.00 PHZA_PHZB PF032840 100.00 Paralemmin PF032857 -0.52 Pox_Ag35 PF032860 100.00 Pox_C7_F8A PF032872 0.22 Pox_D5 PF032882 -0.88 Peptidase_C57 PF032902 -0.88 Pox_MCEL PF032910 100.00 Pox_P4B PF032921 -100.00 Pox_TAA1 PF032950 100.00 Pox_polyA_pol PF032962 -0.88 Ribosomal_S25 PF032971 0.91 TF_AP-2 PF032990 100.00 Tenui_NS4 PF033001 -0.19 Trp_dioxygenase PF033011 0.51 VSP PF033022 -100.00 WTF PF033032 -100.00 Mlp PF033040 100.00 Lipoprotein_X PF033050 100.00 AAL_decarboxy PF033060 100.00 Adeno_E3_15_3 PF03307

42 -0.71 ArgK PF033082 0.22 Cauli_DNA-bind PF033102 0.51 Cornichon PF033111 -100.00 DUF272 PF033120 100.00 SDH_alpha PF033130 100.00 DUF273 PF033140 100.00 SDH_beta PF033150 100.00 ELF PF033170 100.00 EutN_CcmL PF033190 100.00 FBPase_glpX PF033200 100.00 GH3 PF033210 100.00 GerA PF033231 -100.00 Herpes_PAP PF033252 -100.00 Herpes_TAF50 PF033262 -0.88 HpcH_HpaI PF033280 100.00 DPBB_1 PF033301 0.51 PMM PF033321 -100.00 PapB PF033330 100.00 PhaG_MnhG_YufB PF033340 100.00 Pox_C4_C10 PF033361 -100.00 Pox_J1 PF033380 100.00 Pox_L3_FP4 PF03339

Sheet1

0 100.00 Pox_Rif PF033400 100.00 Pox_mRNA-cap PF033411 0.51 SART-1 PF03343

20 -0.05 Daxx PF033441 -0.19 DDOST_48kD PF033450 100.00 TDH PF03347

19 -1.34 Serinc PF033481 -0.19 UPF0114 PF033508 -0.07 DOMON PF033510 100.00 Adenine_glyco PF033524 -1.57 Lin-8 PF033530 100.00 Terminase_1 PF033540 100.00 Pox_TAP PF033551 -100.00 Pox_LP_H2 PF033569 -0.19 Snf7 PF033570 100.00 FMN_red PF033582 -0.19 GKAP PF033593 -0.59 Glyco_transf_43 PF033600 100.00 Herpes_IE2_3 PF033612 -0.19 Polyketide_cyc PF033644 -0.47 YEATS PF033662 -0.19 zf-ZPR1 PF033673 0.10 dsRNA_bind PF033680 100.00 Herpes_UL3 PF033692 -0.19 CBM_21 PF033702 0.22 PRP38 PF03371

13 0.86 Exo_endo_phos PF033721 1.20 ANT PF033741 -100.00 Adeno_E3B PF033761 -0.19 CAS_CSE1 PF033781 -100.00 CcmB PF033791 0.51 CDC50 PF033810 100.00 DUF285 PF033823 -0.19 Serpentine_r_xa PF033830 100.00 DUF287 PF033840 100.00 DUF288 PF033850 100.00 Herpes_UL46 PF033872 -0.19 Lectin_leg-like PF033880 100.00 MobA_MobL PF033891 -0.19 2HCT PF033901 -0.19 Nepo_coat PF033914 1.26 OS-D PF033920 100.00 Pneumo_matrix PF033930 100.00 Pox_E8 PF033941 -100.00 Pox_P4A PF033950 100.00 Pox_RNA_pol_35 PF033960 100.00 Rhabdo_matrix PF033973 -0.59 Ist1 PF033989 -0.44 SAC3_GANP PF033991 -100.00 V1R PF034023 -0.19 PAF-AH_p_II PF034031 -0.19 Mo-co_dimer PF034040 100.00 FA_desaturase_2 PF034050 100.00 Phage_fiber_2 PF034060 100.00 Nucleotid_trans PF034070 100.00 Foamy_virus_ENV PF034082 -0.88 Peptidase_C39 PF03412

Sheet1

0 100.00 PepSY PF034131 -0.19 Glyco_transf_6 PF034142 0.51 Peptidase_C54 PF034162 -0.88 AAT PF034171 -100.00 Peptidase_A25 PF034181 -100.00 Peptidase_U4 PF034192 -0.19 CBM_25 PF034231 -0.19 CBM_11 PF034250 100.00 CBM_15 PF034265 -1.80 CBM_19 PF034270 100.00 RP-C PF034280 100.00 MSP1b PF034291 -100.00 TATR PF034300 100.00 RNA_replicase_B PF034310 100.00 Relaxase PF034321 -100.00 EspA PF034330 100.00 DUF276 PF03434

14 -0.34 Saccharop_dh PF034351 0.51 BtpA PF034370 100.00 Pneumo_NS1 PF034382 -0.88 Spt5-NGN PF034391 -0.19 APT PF034404 -1.57 FAD_binding_7 PF034410 100.00 DUF291 PF034420 100.00 Glyco_hydro_61 PF034430 100.00 DUF294 PF03445

19 -0.93 NAD_binding_2 PF034463 -100.00 NAD_binding_3 PF034471 0.51 MgtE_N PF034480 100.00 GreA_GreB_N PF034495 -0.41 CO_deh_flav_C PF034501 1.20 HELP PF034511 -100.00 Anp1 PF034521 0.91 MoeA_N PF034531 0.51 MoeA_C PF034544 -0.19 dDENN PF034554 0.04 uDENN PF034563 0.10 HA PF034570 100.00 TOBE PF034591 -0.19 TRCF PF034612 -0.88 PCRF PF034622 -0.88 eRF1_1 PF034632 -0.88 eRF1_2 PF034642 -0.19 eRF1_3 PF034650 100.00 LysR_substrate PF034661 -0.19 Smg4_UPF3 PF034671 -100.00 XS PF034680 100.00 XH PF034690 100.00 zf-XS PF034700 100.00 CorC_HlyC PF034710 100.00 Autoind_bind PF034722 0.22 MOSC PF034733 -0.59 DMA PF034740 100.00 3-alpha PF034752 -0.19 MOSC_N PF034762 -0.88 ATP-cone PF034770 100.00 DUF295 PF03478

Sheet1

1 -0.19 DUF296 PF034790 100.00 SBP_bac_7 PF034800 100.00 SUA5 PF034811 -0.19 B3_4 PF034832 0.51 B5 PF034841 -100.00 Arg_tRNA_synt_N PF03485

32 -0.32 HI0933_like PF034863 -100.00 IL13 PF034873 -1.29 Ins_beta PF034882 -0.88 SapB_2 PF034893 0.10 Varsurf_PPLC PF034902 -0.19 5HT_transporter PF034911 -100.00 Methyltransf_7 PF034922 -0.19 BK_channel_a PF034931 -0.19 Beta-APP PF034940 100.00 Binary_toxB PF034950 100.00 Binary_toxA PF034961 -100.00 CDtoxinA PF034981 -100.00 Cellsynth_D PF035002 -0.19 S10_plectin PF035010 100.00 Channel_Tsx PF035020 100.00 Chlam_OMP6 PF035040 100.00 Flu_C_NS1 PF035060 100.00 Connexin50 PF035090 100.00 Peptidase_C24 PF035101 -100.00 Fanconi_A PF035110 100.00 Glyco_hydro_52 PF035120 100.00 GRAS PF035140 100.00 Filaggrin PF035163 -1.29 ICln_channel PF035170 100.00 Invas_SpaK PF035192 -0.88 KCNQ_channel PF035200 100.00 KCl_Cotrans_1 PF035221 -100.00 Macscav_rec PF035230 100.00 CagX PF035240 100.00 Meiotic_rec114 PF035252 -100.00 Microcin PF035262 -0.88 RHS PF035272 0.22 Rabaptin PF035280 100.00 TF_Otx PF035291 0.91 SK_channel PF035301 -0.19 SSrecog PF035310 100.00 OMS28_porin PF035320 100.00 SPO11_like PF035331 0.51 Paxillin PF035355 -0.41 DUF297 PF035370 100.00 VRP1 PF035380 100.00 Spuma_A9PTase PF035393 -1.29 TFIID_30kDa PF035401 0.51 Tuberin PF035420 100.00 Peptidase_C58 PF035430 100.00 TonB PF035441 -0.19 YopE PF035452 -100.00 Treacle PF03546

14 -0.43 Mem_trans PF035470 100.00 LolA PF035480 100.00 PadR PF03551

Sheet1

4 -0.88 Cellulose_synt PF035520 100.00 Herpes_UL73 PF035543 0.10 DUF298 PF035560 100.00 Hexose_dehydrat PF035590 100.00 Allantoicase PF035615 -1.10 MltA PF035621 -100.00 Bunya_G2 PF035631 2.70 DUF1759 PF035640 100.00 Peptidase_A21 PF035667 0.27 Sulfotransfer_2 PF035672 -0.88 Peptidase_C50 PF035681 0.51 Peptidase_M49 PF035710 100.00 Peptidase_S41 PF035720 100.00 OprD PF035732 -100.00 Peptidase_S51 PF035751 -0.19 Peptidase_S58 PF035761 -100.00 Peptidase_C69 PF035772 -0.88 SHP PF035791 -100.00 Herpes_UL14 PF035801 -100.00 Herpes_UL33 PF035812 0.22 LIP PF035830 100.00 Herpes_ICP4_N PF035841 -100.00 Herpes_ICP4_C PF035851 -100.00 Herpes_UL36 PF035861 -0.19 EMG1 PF035870 100.00 Leu_Phe_trans PF035881 -0.19 Antiterm PF035890 100.00 Terminase_2 PF035920 100.00 BenE PF035941 -100.00 C4dic_mal_tran PF035950 100.00 Cad PF035962 -100.00 CcoS PF035970 100.00 CdhC PF035980 100.00 CdhD PF035998 -0.88 CitMHS PF036000 100.00 Cons_hypoth698 PF03601

16 -0.56 Cons_hypoth95 PF036020 100.00 DNA_III_psi PF036035 - DNA_RNApol_7kD PF036043 -100.00 DcuA_DcuB PF036050 100.00 DcuC PF036064 -0.88 DCX PF036070 100.00 EII-GUT PF036080 100.00 EII-Sor PF036091 -100.00 EIIC-GAT PF036112 -0.19 EIIBC-GUT_N PF036120 100.00 EIID-AGA PF036130 100.00 Flag1_repress PF036142 0.22 GCM PF036150 100.00 Glt_symporter PF036161 -100.00 IBV_3A PF036170 100.00 DUF299 PF036183 -0.19 DUF300 PF036190 100.00 MbtH PF036211 -0.19 Focal_AT PF036231 -100.00 COX4_pro PF036261 -100.00 DUF303 PF03629

Sheet1

1 0.51 Fumble PF036301 0.51 Ribonuclease_BN PF036312 -0.88 Glyco_hydro_65m PF036321 -100.00 Glyco_hydro_65C PF036331 -0.19 TCP PF036342 -0.19 Vps35 PF036354 0.04 Mob1_phocein PF036373 -0.19 CXC PF036380 100.00 Lipoprotein_15 PF036404 -1.57 Vps26 PF036432 0.22 Glyco_hydro_85 PF036446 -0.19 Tctex-1 PF036451 -0.19 FlaG PF036462 -0.88 Tmemb_14 PF036470 100.00 Glyco_hydro_67N PF036480 100.00 UPF0014 PF036494 0.04 UPF0041 PF036500 100.00 UPF0081 PF036520 100.00 UPF0093 PF036533 -0.19 Pam16 PF036561 -0.19 UPF0113 PF036570 100.00 Glyco_hydro_71 PF036592 0.22 PHF5 PF036602 -0.88 UPF0121 PF036610 100.00 Glyco_hydro_79n PF036621 0.51 Glyco_hydro_76 PF036632 -0.88 UPF0172 PF036656 -0.88 NPR3 PF036661 -0.19 ATP_bind_2 PF036682 -0.88 UPF0139 PF036695 -0.70 UPF0184 PF036700 100.00 Ufm1 PF03671

11 -0.98 UPF0154 PF036721 -100.00 UPF0128 PF036731 -0.19 UPF0183 PF036760 100.00 UPF0137 PF036770 100.00 Adeno_hexon_C PF036780 100.00 UPF0150 PF036810 100.00 UPF0158 PF036820 100.00 UPF0147 PF036852 -0.19 UPF0146 PF036860 100.00 Nepo_coat_N PF036891 -0.19 UPF0160 PF036900 100.00 UPF0167 PF036910 100.00 UPF0153 PF036921 -100.00 Erg28 PF036940 100.00 UPF0149 PF036950 100.00 UPF0180 PF036980 100.00 UPF0182 PF036991 -100.00 Sorting_nexin PF037000 100.00 UPF0075 PF037021 -100.00 DUF304 PF03703

13 -0.55 BTAD PF037041 -0.19 CheR_N PF037052 -0.88 UPF0104 PF037061 -0.19 MHYT PF037070 100.00 Avian_gp85 PF03708

Sheet1

1 -0.19 OKR_DC_1_N PF037091 -0.19 GlnE PF037101 -100.00 OKR_DC_1_C PF037114 -0.19 Cu2_monoox_C PF037121 -100.00 DUF305 PF037131 1.20 Noc2 PF037150 100.00 WCCH PF037160 100.00 PBP_dimer PF037171 1.20 Ribosomal_S5_C PF037192 -0.88 UDPG_MGDP_dh_C PF03720

10 -0.09 UDPG_MGDP_dh_N PF0372110 -1.10 Hemocyanin_N PF0372210 -1.39 Hemocyanin_C PF037231 -100.00 META PF037245 -0.41 RNase_PH_C PF037251 0.51 PNPase PF037265 -1.10 Hexokinase_2 PF037270 100.00 Viral_DNA_Zn_bi PF037281 -0.19 Ku_C PF037302 0.22 Ku_N PF037315 1.38 Retrotrans_gag PF037321 0.91 ENT PF037351 0.51 EPTP PF037360 100.00 Methyltransf_6 PF037370 100.00 GSP_synth PF037383 -0.59 YjgP_YjgQ PF037391 -100.00 PdxJ PF037401 -100.00 TerC PF037410 100.00 BioW PF037440 100.00 DUF309 PF037450 100.00 LamB_YcsF PF037460 100.00 ADP_ribosyl_GH PF037475 -1.10 FliL PF037481 -100.00 SfsA PF037492 -100.00 DUF310 PF037501 -0.19 HHV6-IE PF037530 100.00 YicC_N PF037550 100.00 AfsA PF037560 100.00 PRONE PF037590 100.00 LEA_1 PF03760

23 -0.76 DUF316 PF037610 100.00 VOMI PF037623 -100.00 Remorin_C PF037634 0.04 EFG_IV PF03764

13 -0.96 CRAL_TRIO_N PF037652 -0.19 Acid_phosphat_B PF037674 -100.00 Attacin_N PF037688 -100.00 Attacin_C PF037694 -1.57 IPK PF037701 -100.00 SPDY PF037710 100.00 Competence PF037721 -100.00 DUF318 PF037731 0.91 MinE PF037760 100.00 DUF320 PF037770 100.00 DUF321 PF037780 100.00 SPW PF037791 -100.00 DUF322 PF03780

Sheet1

1 0.91 FGE-sulfatase PF037811 0.91 AMOP PF037820 100.00 Peptidase_C25_C PF037850 100.00 UxuA PF037860 100.00 RAMPs PF037870 100.00 LrgA PF037881 -0.19 ELK PF037890 100.00 KNOX1 PF037903 -1.29 KNOX2 PF037912 -0.19 PBC PF037920 100.00 PASTA PF037931 -100.00 YCII PF03795

10 -0.70 DnaB_C PF037963 -1.29 TRAM_LAG1_CLN8 PF037981 -0.19 FtsQ PF037991 -0.19 Nuf2 PF038005 -1.10 Ndc80_HEC PF038011 -0.19 CitX PF038025 -0.70 Scramblase PF038031 -0.19 DUF325 PF038040 100.00 ABG_transport PF03806

19 -0.93 F420_oxidored PF038071 -0.19 Glyco_tran_WecB PF03808

18 -0.68 IBN_N PF0381019 -0.04 Ins_element1 PF038111 -0.19 Nrap PF038131 -100.00 LCCL PF038150 100.00 MadM PF038180 100.00 MazG PF038192 0.51 Mtc PF038201 -100.00 Mtp PF038210 100.00 NAF PF038223 0.10 NicO PF038244 -0.19 Nuc_H_symport PF038256 -0.37 OAR PF038260 100.00 Orexin_rec2 PF038277 -0.52 PAP_assoc PF038280 100.00 PTSIIA_gutA PF038290 100.00 PTSIIB_sorb PF038300 100.00 PhnA PF038312 -100.00 WSK PF038323 -0.19 PolC_DP2 PF038331 -0.19 Rad10 PF038342 -0.19 Rad4 PF038354 -0.47 RasGAP_C PF038365 -0.19 Sec62 PF038390 100.00 SecG PF038400 100.00 SelA PF038410 100.00 Silic_transp PF038421 -100.00 Slp PF038430 100.00 Spore_permease PF03845

30 -2.20 TFIID_20kDa PF038478 0.22 TehB PF038481 -0.19 Tfb2 PF038491 0.91 Tfb4 PF038500 100.00 UvdE PF038511 -100.00 Vsr PF03852

Sheet1

1 2.12 YjeF_N PF0385310 -0.41 zf-P11 PF038540 100.00 M-factor PF038551 -100.00 Colicin_im PF038570 100.00 CG-1 PF038590 100.00 DUF326 PF038601 -100.00 ANTAR PF038610 100.00 Phage_mat-A PF038630 100.00 Phage_cap_E PF038640 100.00 ShlB PF038651 -100.00 HAP PF038661 -0.19 FTZ PF038671 -0.19 Ribosomal_L6e_N PF038681 -100.00 Arc PF038691 -0.19 RNA_pol_Rpb8 PF038701 -0.19 RNA_pol_Rpb5_N PF038710 100.00 RseA_C PF038738 -1.17 RNA_pol_Rpb4 PF038741 -100.00 Statherin PF038752 0.22 RNA_pol_Rpb7_N PF038762 -0.19 YIF1 PF038781 -0.19 Cgr1 PF038790 100.00 DbpA PF038807 -2.13 Fructosamin_kin PF038810 100.00 DUF328 PF038831 1.42 DUF329 PF038841 0.51 DUF327 PF038850 100.00 YfbU PF038871 -100.00 MucB_RseB PF038880 100.00 DUF331 PF038890 100.00 DUF333 PF038911 -0.19 NapB PF038920 100.00 XFP PF038942 -100.00 YadA PF03895

15 -0.50 TRAP_alpha PF038960 100.00 ATP_synt_I PF038991 -0.19 Porphobil_deamC PF039004 -0.47 Glyco_transf_22 PF039016 -1.98 Gal4_dimer PF039024 -1.57 DUF334 PF039040 100.00 Phage_T7_tail PF039060 100.00 Spo7 PF039075 0.60 Sec20 PF039083 0.10 BSD PF039092 -100.00 Adeno_PV PF039101 -0.19 Sec61_beta PF039110 100.00 Psb28 PF039125 -0.70 CBF PF039143 -0.59 AIP3 PF039150 100.00 NrfD PF039162 0.22 GSH_synth_ATP PF039170 100.00 CcmH PF039182 -0.88 mRNA_cap_C PF039191 1.76 TLE_N PF039200 100.00 ICAM_N PF039210 100.00 CHASE PF039240 100.00 SeqA PF03925

Sheet1

1 -100.00 NapD PF039270 100.00 DUF336 PF039281 -0.19 PepSY_TM PF039290 100.00 Flp_N PF039309 -100.00 Skp1_POZ PF039312 -0.88 CutC PF039321 -100.00 GspK PF039340 100.00 SKN1 PF039351 -100.00 Terpene_synth_C PF039362 -0.88 Sdh5 PF03937

13 -0.19 OmpH PF039382 -0.88 Ribosomal_L23eN PF039397 -2.13 MSSP PF039400 100.00 INCENP_ARK-bind PF039412 -0.88 DTW PF039422 0.51 TAP_C PF039430 100.00 Endotoxin_C PF039442 -0.88 Endotoxin_N PF039452 -0.19 Ribosomal_L11_N PF039462 -0.88 Ribosomal_L2_C PF039470 100.00 Ribosomal_L9_C PF039489 -1.00 Malic_M PF039491 0.91 tRNA-synt_1c_C PF039502 -0.88 Gln-synt_N PF039513 -1.29 Enolase_N PF03952

13 -0.45 Tubulin_C PF039536 -1.98 Lectin_N PF039542 0.22 Adeno_PIX PF039552 -0.88 Jun PF039572 -0.88 Secretin_N PF039588 -0.32 FSH1 PF039591 0.91 ArsC PF03960

26 -0.27 DUF342 PF0396118 -0.08 Mnd1 PF039626 -0.37 Chorion_2 PF039641 -0.19 Pencillinase_R PF039656 0.42 Trm112p PF039662 -100.00 PRCH PF039670 100.00 OstA PF039683 -0.59 AFG1_ATPase PF039691 -100.00 MmgE_PrpD PF039724 -0.88 Triabin PF039730 100.00 Ecotin PF039740 100.00 PPK2 PF039762 -0.88 Borrelia_REV PF039782 -0.19 Sigma70_r1_1 PF039792 0.51 Nnf1 PF039801 -0.19 Ubiq_cyt_C_chap PF039814 -0.88 DAGAT PF039820 100.00 DUF346 PF039845 - Paf1 PF039851 -0.19 Autophagy_N PF039862 0.22 Autophagy_act_C PF039872 0.51 DUF347 PF039880 100.00 DNA_gyraseA_C PF039891 0.51 DUF348 PF039903 -0.19 DUF349 PF03993

Sheet1

1 0.51 DUF350 PF039941 -0.19 Hema_esterase PF039962 -0.19 VPS28 PF039971 -0.19 Utp11 PF039985 -1.10 MAP65_ASE1 PF039994 -0.19 Sas10_Utp3 PF040000 100.00 Vhr1 PF040011 -0.19 DUF2466 PF040024 0.37 Utp12 PF040032 -0.88 Leo1 PF040042 -0.88 Hus1 PF040051 0.91 Mpp10 PF040060 100.00 DUF354 PF040071 -100.00 DUF356 PF040092 -0.19 DUF357 PF040101 -0.19 LemA PF040114 0.04 PspA_IM30 PF040120 100.00 DUF358 PF040130 100.00 SpoVT_AbrB PF040140 100.00 DUF368 PF040180 100.00 DUF359 PF040190 100.00 DUF360 PF040200 100.00 Staphylcoagulse PF040221 -100.00 FeoA PF040231 -0.19 PspC PF040240 100.00 DUF370 PF040250 100.00 SpoVG PF040260 100.00 DUF371 PF040271 -0.19 DUF374 PF040280 100.00 2-ph_phosp PF040290 100.00 ALO PF040301 0.51 Las1 PF04031

15 -1.10 Rpr2 PF040321 1.20 DUF367 PF040341 -100.00 DUF372 PF040361 -0.19 DUF382 PF040370 100.00 MnhB PF040390 100.00 DUF377 PF040413 -0.19 DNA_pol_E_B PF040423 -1.29 PMEI PF040432 -0.88 P34-Arc PF040455 -0.70 PSP PF040467 -0.05 Sec8_exocyst PF040482 -0.19 APC8 PF040492 0.51 Upf2 PF040503 0.10 TRAPP PF040510 100.00 TolB_N PF04052

14 -0.19 Coatomer_WDAD PF040531 -0.19 Not1 PF040545 - Radical_SAM PF040552 -0.19 Ssl1 PF040561 0.91 Rep-A_N PF040570 100.00 RRM_2 PF040591 -0.19 FeS PF040601 -0.19 ORMDL PF040613 -1.29 P21-Arc PF040622 -0.19 DUF383 PF04063

Sheet1

1 -0.19 DUF384 PF040643 0.10 Not3 PF040653 -0.59 RLI PF040680 100.00 zf-like PF040711 -0.19 LCM PF040720 100.00 YbaK PF040730 100.00 BOF PF040761 -100.00 DsrH PF040774 -0.88 Rcd1 PF040781 -0.19 DUF387 PF040791 -0.19 Per1 PF040800 100.00 DNA_pol_delta_4 PF040810 100.00 Fungal_trans PF04082

23 -0.28 Abhydro_lipase PF040831 0.51 ORC2 PF040840 100.00 MreC PF040853 0.32 SRP-alpha_N PF040862 -0.88 DUF389 PF040873 0.10 Peroxin-13_N PF040881 0.91 BRICHOS PF040890 100.00 RNA_pol_I_TF PF040902 -0.88 Sec15 PF040910 100.00 SAG PF040920 100.00 MreD PF040931 -0.19 DUF390 PF040941 -0.19 NAPRTase PF040951 -0.19 Nucleoporin2 PF040964 -1.57 Nic96 PF040970 100.00 Rad52_Rad22 PF040984 -0.47 Sybindin PF040993 -0.59 Vps53_N PF04100

33 -0.98 Glyco_tran_28_C PF0410123 -0.28 SlyX PF041025 0.28 CD20 PF041032 0.73 DNA_primase_lrg PF041042 -0.88 APG5 PF041061 -100.00 GCS2 PF041071 -0.19 APG17 PF041081 -0.19 APG9 PF041093 -1.29 APG12 PF04110

17 -0.38 APG6 PF041111 -0.19 Mak10 PF041121 -0.19 Gpi16 PF041131 -100.00 Gaa1 PF041140 100.00 Ureidogly_hydro PF041153 -0.19 FA_hydroxylase PF04116

11 -0.98 Mpv17_PMP22 PF041175 -0.70 Dopey_N PF041180 100.00 HSP9_HSP12 PF041192 0.51 Iron_permease PF041202 -0.19 Nup84_Nup100 PF041211 -100.00 CW_binding_2 PF041226 -100.00 DUF373 PF041233 0.10 Dor1 PF041242 -0.19 DFP PF041272 -0.88 Vps52 PF041297 -0.05 Spc97_Spc98 PF04130

Sheet1

1 0.91 NanE PF041312 -100.00 Vps55 PF041331 -0.19 DUF393 PF041343 -1.29 Nop10p PF041354 -1.57 Sec34 PF041361 -0.19 ERO1 PF041370 100.00 GtrA PF041383 -0.59 Rad9 PF041394 -0.19 ICMT PF041407 -0.19 Nuc_sug_transp PF041420 100.00 DUF395 PF041431 -0.19 SCAMP PF04144

29 -0.56 Ctr PF041452 -0.88 YTH PF04146

41 -0.53 Nop14 PF041471 -100.00 Erv26 PF041481 -100.00 DUF397 PF041490 100.00 PPC PF041512 -0.88 Mre11_DNA_bind PF041523 -0.59 NOT2_3_5 PF041532 -0.88 Ground-like PF04155

108 -0.11 IncA PF041565 0.15 EAP30 PF041571 -0.19 Sof1 PF041580 100.00 NB PF041593 -1.29 Arv1 PF041611 -100.00 Gyro_capsid PF041620 100.00 Tht1 PF041630 100.00 DUF400 PF041640 100.00 DUF401 PF041650 100.00 DUF402 PF041670 100.00 DUF403 PF041680 100.00 DUF404 PF041690 100.00 NlpE PF041700 100.00 LrgB PF041721 -100.00 DUF407 PF041740 100.00 DUF406 PF041751 -0.19 TIP41 PF041761 0.51 TAP42 PF041773 0.32 Got1 PF041782 -0.88 Init_tRNA_PT PF041791 -0.19 LTV PF041800 100.00 RPAP2_Rtr1 PF041812 -0.19 B-block_TFIIIC PF041820 100.00 IucA_IucC PF041831 -0.19 ST7 PF041840 100.00 FxsA PF041861 -100.00 DUF399 PF041871 -100.00 Mannosyl_trans2 PF041882 -0.88 Gcd10p PF041891 -0.19 DUF410 PF041901 0.51 Utp21 PF041927 -1.03 PQ-loop PF041933 -0.59 PDCD2_C PF041940 100.00 Transposase_28 PF041950 100.00 Sugar-bind PF041980 100.00 Lipoprotein_17 PF04200

Sheet1

3 0.10 TPD52 PF042010 100.00 Sortase PF042030 100.00 FMN_bind PF042050 100.00 MtrE PF042060 100.00 MtrD PF042070 100.00 MtrA PF042083 -1.29 HgmA PF042092 0.22 MtrG PF04210

18 0.01 MIT PF042120 100.00 HtaA PF042135 -1.80 FdhE PF042160 100.00 DUF412 PF04217

11 -0.02 CENP-B_N PF042181 -0.19 DUF413 PF042192 -0.19 DUF414 PF042201 -100.00 RelB PF042211 -100.00 DUF416 PF042220 100.00 CitF PF042230 100.00 DUF417 PF042241 -100.00 OapA PF042252 -0.88 Transgly_assoc PF042261 -0.19 Indigoidine_A PF042272 -0.19 Zn_peptidase PF042281 -100.00 PS_pyruv_trans PF042300 100.00 Endonuclease_1 PF042310 100.00 SpoVS PF042320 100.00 Phage_Mu_F PF042331 -100.00 CopC PF042340 100.00 DUF418 PF042350 100.00 Transp_Tc5_C PF042360 100.00 DUF419 PF042371 -100.00 DUF420 PF042380 100.00 DUF421 PF042390 100.00 DUF422 PF042401 -0.19 DUF423 PF042411 -100.00 DUF424 PF042421 -0.19 DPRP PF042442 -100.00 RseC_MucC PF042461 -0.19 DUF429 PF042501 -100.00 TFR_dimer PF042530 100.00 DUF432 PF042541 -100.00 DUF433 PF042552 -100.00 DUF434 PF042560 100.00 Exonuc_V_gamma PF042572 -0.19 Peptidase_A22B PF042580 100.00 DUF436 PF042601 -0.19 Dyp_perox PF042611 -100.00 Glu_cys_ligase PF042622 -0.88 TPK_catalytic PF042630 100.00 YceI PF042641 -0.19 TPK_B1_binding PF042651 -100.00 ASCH PF042661 -0.19 SoxD PF042673 -0.19 SoxG PF042680 100.00 DUF440 PF042690 100.00 Phospholamban PF042721 -0.19 P-mevalo_kinase PF04275

Sheet1

3 -1.29 DUF443 PF042766 -1.29 OAD_gamma PF042770 100.00 IspA PF042794 -100.00 Tim44 PF042804 -0.19 Tom22 PF042810 100.00 DUF438 PF042820 100.00 CheF-arch PF042830 100.00 DUF441 PF042841 -0.19 DUF444 PF042855 0.15 DUF445 PF042860 100.00 DUF446 PF042870 100.00 MukE PF042882 -100.00 DUF447 PF042891 -0.19 DctQ PF042901 -100.00 GD_AH_C PF042950 100.00 DUF448 PF042960 100.00 UPF0122 PF042970 100.00 Zn_peptidase_2 PF042980 100.00 FMN_bind_2 PF042990 100.00 FBA PF043002 -100.00 DUF452 PF043010 100.00 DUF454 PF043040 100.00 DUF457 PF043070 100.00 DUF458 PF043080 100.00 G3P_antiterm PF043092 -0.88 MukB PF043100 100.00 DUF459 PF043110 100.00 DUF460 PF043120 100.00 HSDR_N PF043130 100.00 DUF461 PF043141 -100.00 DUF462 PF043150 100.00 FlgM PF043160 100.00 NifZ PF04319

22 -0.39 RmlD_sub_bind PF043211 -100.00 DUF473 PF043221 0.51 Fer2_BFD PF043242 0.91 DUF465 PF043250 100.00 AAA_4 PF043260 100.00 DUF466 PF043280 100.00 VacJ PF043331 -0.19 VirB8 PF043351 -0.19 DUF479 PF043360 100.00 DUF480 PF043370 100.00 DUF481 PF043380 100.00 DUF482 PF043390 100.00 DUF484 PF043404 -1.57 DUF485 PF043411 -100.00 DUF486 PF043420 100.00 DUF488 PF043431 -100.00 CheZ PF043440 100.00 LppC PF043480 100.00 MdoG PF043490 100.00 PilO PF043501 -100.00 PilP PF043510 100.00 Rsd_AlgQ PF043530 100.00 SmpA_OmlA PF043553 -100.00 DUF489 PF04356

Sheet1

0 100.00 DsrC PF043581 -100.00 DUF493 PF04359

42 -2.32 Serglycin PF043601 -100.00 DUF494 PF043611 0.91 DUF496 PF043631 -100.00 DNA_pol3_chi PF043640 100.00 DUF497 PF043650 100.00 DUF500 PF043661 -0.19 DUF502 PF043670 100.00 DUF507 PF043681 -0.19 DUF508 PF043701 -100.00 PAD_porph PF043711 -100.00 DUF511 PF043736 -1.29 HemX PF043751 -0.19 ATE_N PF043761 -100.00 ATE_C PF043771 -0.19 DUF525 PF043791 0.51 DUF526 PF043800 100.00 SAB PF043820 100.00 KilA-N PF043830 100.00 DUF528 PF043840 100.00 FAINT PF043850 100.00 SspB PF043862 -0.88 PTPLA PF04387

12 -1.57 Hamartin PF0438825 -1.62 Peptidase_M28 PF043890 100.00 RplB PF043904 -1.57 DUF533 PF04391

20 -0.54 Poxvirus_B22R PF043950 100.00 LytTR PF043970 100.00 DUF538 PF043982 -100.00 Glutaredoxin2_C PF043990 100.00 DUF540 PF044010 100.00 SIMPL PF044022 -100.00 ERF PF044041 -0.19 ScdA_N PF044051 -0.19 TP6A_N PF04406

14 -0.43 HA2 PF044080 100.00 DUF530 PF044092 -0.88 Gar1 PF044100 100.00 DUF524 PF044110 100.00 DUF521 PF044120 100.00 Glycos_transf_N PF044134 -1.57 DUF515 PF044151 -100.00 DUF501 PF044172 -0.19 DUF543 PF044184 0.22 4F5 PF044193 -0.59 CHD5 PF044201 0.51 Mss4 PF044210 100.00 FrhB_FdhB_N PF04422

24 -0.11 Rad50_zn_hook PF044230 100.00 DUF544 PF044240 100.00 Bul1_N PF044251 -100.00 Bul1_C PF044265 - Brix PF044271 -100.00 Choline_kin_N PF044281 -0.19 DUF498 PF04430

Sheet1

1 -100.00 Pec_lyase_N PF044310 100.00 FrhB_FdhB_C PF044323 -0.19 SWIRM PF044331 1.61 SWIM PF044342 -100.00 SPK PF044351 1.20 RINT1_TIP1 PF04437

16 0.37 zf-HIT PF044380 100.00 Adenyl_transf PF044392 -0.88 Dysbindin PF044400 100.00 Pox_VERT_large PF044412 -0.88 CtaG_Cox11 PF044420 100.00 DUF548 PF044451 0.91 Thg1 PF044460 100.00 DUF551 PF044483 -1.29 BSP PF044502 -100.00 Methyltrans_RNA PF044521 -100.00 Linocin_M18 PF044540 100.00 DUF503 PF044560 100.00 DUF505 PF044580 100.00 DUF520 PF044610 100.00 Glyphos_transf PF044640 100.00 Terminase_3 PF044660 100.00 PSP1 PF044680 100.00 DUF552 PF044720 100.00 DUF555 PF044751 -0.19 Mid2 PF044780 100.00 DUF559 PF044801 -100.00 DUF561 PF044814 -1.57 DUF566 PF044840 100.00 NblA PF044850 100.00 SchA_CurD PF044862 -0.19 CITED PF044873 -1.29 Gly_transf_sug PF044881 -100.00 DUF570 PF044890 100.00 Pox_T4_C PF044900 100.00 Phage_rep_O PF044923 -0.19 TFIID_90kDa PF04494

26 -1.25 GRASP55_65 PF044951 -100.00 Herpes_UL35 PF04496

10 -0.19 SAPS PF044994 -1.57 FLYWCH PF045001 -0.19 Baculo_VP39 PF045018 -0.88 DUF572 PF045021 -0.19 SSDP PF045031 -100.00 DUF573 PF045040 100.00 CD225 PF045051 -0.19 Rft-1 PF04506

10 -0.54 Pox_A_type_inc PF045080 100.00 DUF577 PF045102 0.22 DER1 PF045110 100.00 Baculo_PEP_N PF04512

37 -0.54 Baculo_PEP_C PF045134 0.37 BTV_NS2 PF045144 -0.19 Choline_transpo PF045152 -0.19 CP2 PF045160 100.00 Microvir_lysis PF045170 100.00 DUF582 PF04518

Sheet1

2 -0.88 DUF583 PF045194 -1.57 DUF584 PF045200 100.00 Viral_P18 PF045210 100.00 DUF585 PF045222 -100.00 Herpes_U30 PF045230 100.00 DUF567 PF04525

13 -2.75 Retinin_C PF045271 -100.00 Adeno_E4_34 PF045280 100.00 Herpes_U59 PF045290 100.00 Viral_Beta_CD PF045300 100.00 Phage_holin_1 PF045310 100.00 DUF587 PF045320 100.00 Herpes_U44 PF045330 100.00 Herpes_UL56 PF045340 100.00 Herpes_UL55 PF045370 100.00 BEX PF045380 100.00 Sigma70_r3 PF045390 100.00 Sigma70_r2 PF045424 0.22 Sigma70_r4 PF04545

11 0.19 Sigma70_ner PF045465 -0.41 Anoctamin PF04547

19 -0.73 AIG1 PF045481 -100.00 Phage_holin_2 PF045500 100.00 Sigma54_DBD PF045521 -0.19 Tis11B_N PF045530 100.00 XhoI PF045550 100.00 DpnII PF045561 -0.19 tRNA_synt_1c_R2 PF045572 -0.88 tRNA_synt_1c_R1 PF045580 100.00 Herpes_UL17 PF045594 -0.88 RNA_pol_Rpb2_7 PF045603 -0.19 RNA_pol_Rpb2_2 PF045610 100.00 Dicty_spore_N PF045623 0.10 RNA_pol_Rpb2_1 PF04563

11 -0.28 U-box PF045643 -0.19 RNA_pol_Rpb2_3 PF045655 -0.70 RNA_pol_Rpb2_4 PF045663 -0.19 RNA_pol_Rpb2_5 PF045672 0.51 IATP PF045680 100.00 DUF591 PF045692 0.22 DUF581 PF045701 -0.19 Lipin_N PF045712 -0.19 Gb3_synth PF045721 -0.19 SPC22 PF045731 -100.00 DUF592 PF045740 100.00 DUF560 PF045753 -100.00 DUF593 PF045761 -0.19 DUF563 PF045770 100.00 Keratin_matx PF04579

65 -0.11 Reo_sigmaC PF045821 -100.00 Baculo_p74 PF045831 -0.19 Pox_A28 PF045843 -1.29 ADP_PFK_GK PF045875 -0.70 HIG_1_N PF045881 -100.00 DUF596 PF04591

19 -0.49 SelP_N PF045921 -100.00 Pox_F15 PF04596

Sheet1

1 0.51 Ribophorin_I PF045971 -0.19 Gasdermin PF045981 -100.00 Pox_G5 PF045997 -0.19 DUF571 PF046004 -0.88 DUF569 PF046010 100.00 Arabinose_trans PF046020 100.00 L_biotic_typeA PF046042 0.51 Ogr_Delta PF046060 100.00 RelA_SpoT PF046071 -0.19 PgpA PF046081 -100.00 TrbL PF046100 100.00 AalphaY_MDB PF046110 100.00 GspM PF046120 100.00 LpxD PF046131 -0.19 Pex19 PF046145 -0.41 Utp14 PF046150 100.00 HD-ZIP_N PF046180 100.00 FlaA PF046201 -0.19 ETS_PEA3_N PF046210 100.00 Adeno_E1B_55K_N PF046231 -100.00 Dec-1 PF046246 -100.00 DEC-1_N PF046251 -100.00 DEC-1_C PF046262 -100.00 ATP-synt_Eps PF046274 -0.47 Sedlin_N PF046281 0.51 ICA69 PF046290 100.00 Phage_tail PF046300 100.00 Baculo_44 PF04631

15 -0.19 FUSC PF046320 100.00 Herpes_BMRF2 PF046331 -0.19 DUF600 PF046346 -0.88 PA26 PF046360 100.00 Herpes_pp85 PF046371 -0.19 Baculo_E56 PF046393 -1.29 PLATZ PF04640

15 -0.50 Rtf2 PF046413 -100.00 DUF601 PF046420 100.00 Motilin_assoc PF046430 100.00 DUF603 PF046450 100.00 DUF604 PF046460 100.00 AgrB PF046470 100.00 YSIRK_signal PF046500 100.00 Pox_A12 PF04651

36 -0.73 DUF605 PF046520 100.00 DUF599 PF046540 100.00 APH_6_hur PF046550 100.00 DUF606 PF046571 0.51 TAFII55_N PF046580 100.00 Arch_fla_DE PF046590 100.00 Nanovirus_coat PF046600 100.00 Pox_I3 PF046610 100.00 Luteo_PO PF04662

10 -0.88 Pox_A32 PF046652 -100.00 Glyco_transf_54 PF046662 -100.00 Endosulfine PF046674 -1.57 Tsg PF046681 -0.19 DUF579 PF04669

Sheet1

68 -0.48 Gtr1_RagA PF046700 100.00 Ag332 PF046710 100.00 DUF574 PF046720 100.00 Cyclase_polyket PF046731 -100.00 Phi_1 PF046744 -0.19 DNA_ligase_A_N PF046752 -0.88 CwfJ_C_2 PF046764 -0.47 CwfJ_C_1 PF046774 -0.88 DUF607 PF046784 -0.19 DNA_ligase_A_C PF046791 -100.00 Bys1 PF046818 -2.27 Proteasom_Rpn13 PF04683

42 -0.93 BAF1_ABF1 PF046841 -100.00 DUF608 PF046850 100.00 SsgA PF046860 100.00 Microvir_H PF046870 100.00 Phage_holin PF046882 0.22 S1FA PF046892 -0.88 YABBY PF046901 0.51 ApoC-I PF046910 100.00 PDGF_N PF046921 -100.00 Transposase_29 PF046930 100.00 Corona_3 PF04694

29 -0.66 Pex14_N PF046952 -0.88 Pinin_SDK_memA PF046961 -0.19 Pinin_SDK_N PF046971 -0.19 P16-Arc PF046991 -0.19 Baculo_gp41 PF047003 -100.00 Vicilin_N PF047020 100.00 FaeA PF047030 100.00 TSNR_N PF047050 100.00 Dickkopf_N PF047064 0.22 PRELI PF047072 -0.19 Pellino PF047101 -100.00 ApoA-II PF047113 -0.19 Radial_spoke PF047121 -0.19 Pox_I5 PF047132 -100.00 BCL_N PF047141 0.51 ETC_C1_NDUFA5 PF047162 -0.88 ATP-synt_G PF047182 -0.88 TAFII28 PF047190 100.00 DUF506 PF047201 0.51 DUF750 PF047211 -0.19 Ssu72 PF047220 100.00 GRDA PF047232 -0.88 Glyco_transf_17 PF047240 100.00 PsbR PF047250 100.00 Microvir_J PF047262 -0.19 ELMO_CED12 PF047271 -100.00 LPP PF047281 -0.19 ASF1_hist_chap PF047291 -100.00 Filament_head PF047325 0.15 Coatomer_E PF047332 0.51 Ceramidase_alk PF047341 -100.00 Eclosion PF047361 -100.00 Lant_dehyd_C PF047381 -100.00 AMPKBI PF04739

Sheet1

1 0.91 Transposase_30 PF047400 100.00 InvH PF047410 100.00 Monooxygenase_B PF047440 100.00 Pox_A8 PF047450 100.00 DUF575 PF047460 100.00 DUF612 PF047471 -0.19 Polysacc_deac_2 PF047482 -0.88 PLAC8 PF047494 -1.57 Far-17a_AIG1 PF047500 100.00 DUF615 PF047512 -0.88 ChaC PF047520 100.00 Transposase_31 PF047540 100.00 PAP_fibrillin PF047552 -0.88 OST3_OST6 PF047563 -0.59 Pex2_Pex12 PF047572 -0.88 Ribosomal_S30 PF047580 100.00 IF2_N PF047600 100.00 Phage_Treg PF04761

15 -0.70 IKI3 PF047621 -0.19 DUF613 PF047640 100.00 Baculo_p26 PF047661 -100.00 Pox_F17 PF047670 100.00 DUF619 PF047681 -100.00 MAT_Alpha1 PF047690 100.00 CAV_VP3 PF047711 -100.00 Flu_B_M2 PF047723 -1.29 HABP4_PAI-RBP1 PF047740 100.00 DUF626 PF04776

11 -0.39 Evr1_Alr PF047770 100.00 LMP PF04778

15 -0.19 DUF629 PF047802 0.51 DUF627 PF047810 100.00 DUF632 PF047821 -100.00 DUF630 PF047830 100.00 DUF547 PF047842 -100.00 Rhabdo_M2 PF047851 -100.00 Baculo_DNA_bind PF047860 100.00 Pox_H7 PF047870 100.00 DUF620 PF047880 100.00 DUF621 PF047892 0.22 Sarcoglycan_1 PF04790

11 -0.02 LMBR1 PF047910 100.00 Herpes_BBRF1 PF047931 0.51 PAPA-1 PF047951 -100.00 RepA_C PF047960 100.00 Herpes_ORF11 PF047971 -0.19 Baculo_19 PF047985 0.15 Fzo_mitofusin PF047992 -0.88 ETC_C1_NDUFA4 PF048001 0.51 Sin_N PF048011 -0.19 SMK-1 PF048024 -100.00 Cor1 PF048030 100.00 Pox_E10 PF048051 -100.00 EspF PF048060 100.00 CTV_P23 PF048080 100.00 HupH_C PF04809

10 0.22 zf-Sec23_Sec24 PF04810

Sheet1

4 -0.88 Sec23_trunk PF048110 100.00 HNF-1B_C PF048124 -0.47 Sec23_helical PF048150 100.00 DUF633 PF048161 -100.00 Umbravirus_LDM PF048175 -0.19 DUF618 PF048180 100.00 DUF716 PF048198 0.13 Trp_halogenase PF048202 -0.19 TIMELESS PF048213 -1.29 DUF622 PF048220 100.00 Herpes_UL49_2 PF048230 100.00 Rad21_Rec8 PF048241 0.51 Rad21_Rec8_N PF048259 -0.44 DUF634 PF048261 3.88 Plant_tran PF048273 -0.19 GFA PF048280 100.00 DUF638 PF048291 -100.00 DUF637 PF048301 0.51 Popeye PF048310 100.00 SOUL PF048320 100.00 Adeno_E3_14_5 PF048340 100.00 Pox_A9 PF048351 0.91 IFRD_C PF048360 100.00 MbeB_N PF048371 -100.00 Baculo_LEF5 PF048380 100.00 PSRP-3_Ycf65 PF048392 -0.19 Vps16_C PF048401 -0.19 Vps16_N PF048411 -100.00 DUF639 PF048422 0.22 Herpes_teg_N PF048430 100.00 DUF623 PF048442 0.51 PurA PF048451 -100.00 Herpes_pp38 PF048463 -0.59 Calcipressin PF048470 100.00 Pox_A22 PF048481 0.51 HAP1_N PF04849

76 -0.31 ResIII PF048510 100.00 DUF624 PF048541 -0.19 SNF5 PF048552 -100.00 Securin PF048561 0.91 CAF1 PF048571 -0.19 TH1 PF048587 0.64 DUF641 PF048590 100.00 Phage_portal PF048600 100.00 EGF_alliinase PF048630 100.00 Alliinase_C PF048640 100.00 Rota_NS6 PF048660 100.00 DUF643 PF048671 -0.19 Uso1_p115_head PF048691 -100.00 DUF644 PF048702 -0.19 Uso1_p115_C PF048712 -0.88 Mak16 PF048742 -0.88 Tenui_NCP PF048760 100.00 Baculo_p48 PF048780 100.00 Molybdop_Fe4S4 PF048793 0.10 NUDE_C PF048800 100.00 Adeno_GP19K PF04881

Sheet1

2 -100.00 Peroxin-3 PF048822 -0.88 DUF647 PF048840 100.00 Stig1 PF048854 0.04 PT PF048860 100.00 Pox_M2 PF048873 -0.59 SseC PF048889 -0.59 Cwf_Cwc_15 PF048890 100.00 DUF648 PF048907 -1.03 Yip1 PF048930 100.00 DUF651 PF048951 -0.19 Glu_syn_central PF048983 0.79 MbeD_MobD PF048993 0.32 Fcf1 PF049002 -0.88 RAMP PF049012 -0.88 NCD1 PF049041 0.51 NCD2 PF049056 -0.37 Tweety PF049065 -0.70 SH3BGR PF049082 -100.00 Amidohydro_2 PF049091 0.51 DUF654 PF049100 100.00 ATP-synt_J PF049112 -0.19 Dynamitin PF049120 100.00 Baculo_Y142 PF049130 100.00 DltD_C PF049141 -100.00 DltD_N PF049151 -0.19 Phospholip_B PF049160 100.00 Shufflon_N PF049171 0.51 DltD_M PF049180 100.00 DUF656 PF049203 -1.29 XAP5 PF049212 -0.88 DIE2_ALG10 PF049224 -0.88 Ninjurin PF049232 -100.00 Pox_A6 PF049241 0.51 SHQ1 PF049251 0.51 PAP_RNA-bind PF049260 100.00 SMP PF049272 -0.88 PAP_central PF04928

11 -100.00 Herpes_DNAp_acc PF049293 -1.29 FUN14 PF049306 -0.59 DNA_pol_phi PF049312 0.73 Wzy_C PF049322 -0.88 Med6 PF049341 -0.19 SURF6 PF049350 100.00 DUF658 PF049362 -0.88 DUF659 PF049371 -0.19 SIP1 PF049381 -0.19 RRS1 PF049390 100.00 BLUF PF049401 -0.19 CC PF049420 100.00 Pox_F11 PF049430 100.00 YHS PF049452 -0.19 Pox_VLTF3 PF049470 100.00 Pox_A51 PF049482 -0.19 DUF662 PF049492 -0.19 DUF663 PF049506 -0.37 AstE_AspA PF049520 100.00 SIP PF04954

Sheet1

0 100.00 TrbC PF049560 100.00 RMF PF049576 -0.03 ARS2 PF049592 0.22 Glutaminase PF049600 100.00 FTCD_C PF049610 100.00 KduI PF049620 100.00 Sigma54_CBD PF049630 100.00 Flp_Fap PF049640 100.00 GPW_gp25 PF049651 0.51 HTH_10 PF049673 0.32 CHORD PF04968

10 -0.19 CS PF049694 -1.57 NC PF049700 100.00 Lysis_S PF049711 -100.00 BON PF04972

33 0.25 DivIC PF049770 100.00 DUF664 PF049784 -1.57 IPP-2 PF049792 -0.19 NMD3 PF049811 -0.19 HPP PF049823 -0.59 RNA_pol_Rpb1_3 PF049830 100.00 Phage_sheath_1 PF049841 -100.00 Phage_tube PF049850 100.00 Transposase_32 PF049865 -1.80 PigN PF04987

13 -0.96 AKAP95 PF049882 -0.19 CmcI PF049891 -0.19 RNA_pol_Rpb1_7 PF049901 0.51 LicD PF049912 -0.19 RNA_pol_Rpb1_6 PF049920 100.00 TfoX_C PF049941 0.51 CcmD PF049954 -0.47 RNA_pol_Rpb1_1 PF049973 -0.59 RNA_pol_Rpb1_5 PF049981 -0.19 FtsL PF049993 0.10 RNA_pol_Rpb1_4 PF050000 100.00 RNA_pol_Rpb1_R PF050013 -0.59 SGS PF050020 100.00 DUF668 PF050033 0.10 IFRD PF050044 -100.00 Ocnus PF050050 100.00 DUF666 PF050061 -0.19 Mannosyl_trans PF050077 -1.03 V-SNARE PF050081 -0.19 EBV-NA3 PF050091 1.20 TACC PF050101 -0.19 DBR1 PF050110 100.00 Nuc_deoxyrib_tr PF050141 -0.19 Plasmid_killer PF050152 -100.00 Plasmid_stabil PF050162 0.22 DUF667 PF050181 0.51 Coq4 PF050192 -0.88 zf-NPL4 PF050201 0.51 NPL4 PF050210 100.00 SRP40_C PF050220 100.00 Phytochelatin PF050231 -0.19 Gpi1 PF05024

Sheet1

0 100.00 RbsD_FucU PF050251 -0.19 DCP2 PF050261 0.51 PARG_cat PF050283 -1.29 TIMELESS_C PF050291 1.42 SSXT PF050301 -100.00 NEAT PF050313 -0.19 Pre-SET PF050332 -0.19 SPOR PF050363 -0.59 Cytochrom_B558a PF050380 100.00 Agouti PF050391 -0.19 Pecanex_C PF050419 -1.29 Caleosin PF050420 100.00 Mga PF050431 1.20 Prox1 PF050442 -0.19 Img2 PF050464 -0.47 L51_S25_CI-B8 PF050473 -100.00 NosD PF05048

11 -1.20 IIGP PF050492 -0.19 COX17 PF050511 -0.19 MerE PF050527 -0.52 Menin PF050530 100.00 DUF673 PF050543 -1.29 DUF677 PF050551 0.51 DUF674 PF05056

10 0.08 DUF676 PF050570 100.00 ActA PF050581 -0.19 MGAT2 PF050601 -100.00 Pox_A11 PF050610 100.00 RICH PF050623 0.10 MT-A70 PF050636 -0.59 Nsp1_C PF050640 100.00 Phage_capsid PF050651 -100.00 RNA_pol_delta PF050660 100.00 Mn_catalase PF050670 100.00 MtlR PF050680 100.00 Phage_tail_S PF050691 0.51 NDUFA12 PF050710 100.00 Herpes_UL43 PF050723 -0.59 Baculo_p24 PF050731 -100.00 DUF684 PF050751 -0.19 SUFU PF050761 -100.00 DUF678 PF050770 100.00 DUF682 PF050812 -0.88 DUF683 PF050820 100.00 LST1 PF050831 0.51 GRA6 PF05084

34 -0.31 Dicty_REP PF050860 100.00 Rota_VP2 PF050872 -100.00 Bac_GDH PF050884 -0.88 NAGLU PF050891 -0.19 VKG_Carbox PF050907 -0.75 eIF-3_zeta PF050910 100.00 DUF686 PF050922 0.22 CIAPIN1 PF050930 100.00 DUF687 PF050950 100.00 Glu_cyclase_2 PF050962 -100.00 DUF688 PF05097

Sheet1

0 100.00 LEF-4 PF050986 -100.00 TerB PF050991 -100.00 Phage_tail_L PF051002 -0.88 VirB3 PF051010 100.00 Holin_BlyA PF05102

11 -0.02 DivIVA PF051032 -100.00 Rib_recp_KP_reg PF051041 -100.00 Phage_holin_4 PF051050 100.00 Phage_holin_3 PF051061 -100.00 DUF694 PF051070 100.00 DUF690 PF051083 -1.29 Herpes_BLLF1 PF051096 -1.29 AF-4 PF051100 100.00 Amelin PF051111 -100.00 DUF692 PF051140 100.00 PetL PF051151 -0.19 S6PP PF051160 100.00 DUF695 PF051170 100.00 Asp_Arg_Hydrox PF051180 100.00 Terminase_4 PF051192 0.22 GvpG PF051200 100.00 GvpK PF051210 100.00 S_layer_N PF051230 100.00 S_layer_C PF051247 0.06 DUF699 PF051271 -100.00 DUF697 PF05128

31 -0.07 Elf1 PF051297 -2.13 FlgN PF051301 -0.19 Pep3_Vps18 PF051311 -0.19 RNA_pol_Rpc4 PF051323 -100.00 GspL PF051341 -0.19 Phage_QLRG PF051350 100.00 Phage_portal_2 PF051364 -0.88 PilN PF051371 -100.00 PaaA_PaaC PF051380 100.00 Erythro_esteras PF051392 0.22 ResB PF051401 -100.00 DIT1_PvcA PF051411 -0.19 DUF702 PF051420 100.00 Phage_CRI PF051441 0.91 LANC_like PF051475 -0.19 Methyltransf_8 PF051480 100.00 Flagellar_rod PF051490 100.00 Legionella_OMP PF051500 100.00 PsbM PF051511 -0.19 DUF706 PF051534 -0.19 TM2 PF051541 -0.19 Phage_X PF051551 -100.00 GSPII_E_N PF051573 -0.59 RNA_pol_Rpc34 PF051580 100.00 Capsule_synth PF051591 -100.00 DSS1_SEM1 PF051601 -0.19 MOFRL PF051611 -100.00 Ribosomal_L41 PF051620 100.00 DinB PF051630 100.00 ZapA PF051641 -100.00 HEPN PF05168

Sheet1

0 100.00 HemS PF051719 -1.29 MPPN PF051722 -100.00 DapB_C PF051730 100.00 CDRN PF05174

39 -0.27 MTS PF051751 -0.19 ATP-synt_10 PF051764 -100.00 Kri1 PF051784 -0.88 CDC73 PF051793 0.10 zf-DNL PF051801 -0.19 XPA_C PF051811 -0.19 Fip1 PF051824 0.22 SapB_1 PF051848 -0.47 PRMT5 PF051855 -0.19 Dpy-30 PF051861 0.51 ETF_QO PF051873 -0.19 MutS_II PF051882 -0.88 RTC_insert PF051892 0.51 MutS_IV PF051909 0.32 ADK_lid PF051912 0.73 MutS_III PF051927 -0.19 Peptidase_M16_C PF051931 -100.00 UreE_C PF051943 -0.59 AMP_N PF051950 100.00 PTN_MK_N PF051962 -0.19 TRIC PF051971 -0.19 IF3_N PF05198

17 0.31 GMC_oxred_C PF051992 -100.00 Hom_end_hint PF052031 -100.00 COMPASS-Shg1 PF052052 -0.88 TRM13 PF052063 0.51 zf-CSL PF052071 -0.19 ALG3 PF052080 100.00 MinC_N PF052092 -0.19 Sprouty PF052101 -100.00 NLBH PF052110 100.00 DUF707 PF052121 -0.19 UNC-50 PF052161 -0.19 STOP PF052170 100.00 DUF713 PF052184 0.83 DREV PF052190 100.00 MgpC PF052203 -0.59 AdoHcyase PF052212 -0.88 AlaDh_PNT_N PF052220 100.00 MecA_N PF052231 -0.19 NDT80_PhoG PF052249 0.51 HTH_psq PF052250 100.00 CHASE2 PF052261 0.91 CHASE3 PF052270 100.00 CHASE4 PF052280 100.00 MASE2 PF052300 100.00 MASE1 PF052312 -100.00 BTP PF052320 100.00 PHB_acc PF052330 100.00 CHAD PF052357 -2.13 TAF4 PF052364 -0.47 MoeZ_MoeB PF052370 100.00 CHL4 PF05238

Sheet1

0 100.00 PRC PF052390 100.00 EBP PF052410 100.00 GLYCAM-1 PF052420 100.00 Brucella_OMP2 PF052440 100.00 DUF735 PF052461 -0.19 UPF0193 PF052501 -0.19 UPF0197 PF052515 -0.70 zf-U11-48K PF052534 0.37 UPF0203 PF052541 0.91 UPF0220 PF052551 -0.19 UPF0223 PF052560 100.00 CHAP PF052570 100.00 DUF721 PF052580 100.00 Tra_M PF052616 -0.37 Borrelia_P83 PF052621 -0.19 DUF722 PF052631 -100.00 CfAFP PF052640 100.00 DUF723 PF052653 0.79 DUF724 PF05266

15 -2.20 DUF725 PF052671 -100.00 Phage_CII PF052690 100.00 AbfB PF052701 1.42 VirE PF052721 -100.00 CopB PF052752 -0.19 SH3BP5 PF052760 100.00 DUF726 PF052772 -0.19 PEARLI-4 PF05278

11 -0.64 Asp-B-Hydro_N PF052790 100.00 FlhC PF052801 0.51 Secretogranin_V PF052811 -100.00 AAR2 PF052825 -1.10 MGC-24 PF052830 100.00 DUF736 PF05284

16 -0.39 SDA1 PF052850 100.00 PMG PF052871 -0.19 Pox_A3L PF052880 100.00 BLYB PF052899 -1.29 Baculo_IE-1 PF052901 -100.00 Bystin PF052910 100.00 MCD PF052921 -100.00 ASFV_L11L PF052930 100.00 Toxin_5 PF052941 -0.19 Luciferase_N PF052951 -0.19 TAS2R PF052963 0.10 Herpes_LMP1 PF052970 100.00 Bombinin PF052981 -0.19 Peptidase_M61 PF052994 -0.88 DUF737 PF053002 -0.88 Mec-17 PF053014 -0.88 DUF727 PF053030 100.00 DUF728 PF053041 -0.19 DUF732 PF053058 -1.57 DUF733 PF05306

14 0.06 DUF729 PF053080 100.00 Baculo_PP31 PF053112 -0.88 Pox_P21 PF053131 -100.00 Baculo_ODV-E27 PF05314

Sheet1

0 100.00 VAR1 PF053160 100.00 Thermopsin PF053173 -1.29 Pox_RNA_Pol_19 PF053200 100.00 HHA PF053210 100.00 NinE PF053221 -100.00 Pox_A21 PF053230 100.00 DUF730 PF053250 100.00 SVA PF053267 0.06 RRN3 PF053272 -0.19 CybS PF053280 100.00 DUF742 PF053310 100.00 DUF743 PF053323 -0.59 DUF719 PF05334

21 -1.62 DUF745 PF053350 100.00 DUF718 PF053360 100.00 CSF-1 PF053370 100.00 DUF717 PF053381 -100.00 DUF739 PF053391 0.51 DUF740 PF053400 100.00 DUF708 PF053410 100.00 Peptidase_M26_N PF053421 -100.00 Peptidase_M42 PF053430 100.00 DUF746 PF053442 -100.00 He_PIG PF053453 -1.29 DUF747 PF053466 0.10 Complex1_LYR PF053471 -0.19 UMP1 PF053480 100.00 GSK-3_bind PF053502 -0.88 GMP_PDE_delta PF053510 100.00 Phage_connector PF053520 100.00 Atracotoxin PF053532 -100.00 Phage_attach PF053541 -0.19 Apo-CII PF053550 100.00 Phage_Coat_A PF053570 100.00 DicB PF053580 100.00 DUF748 PF053590 100.00 YiaAB PF053601 -0.19 PP1_inhibitor PF053611 -0.19 Lon_C PF053620 100.00 Herpes_US12 PF053630 100.00 SecIII_SopE_N PF053641 -0.19 UCR_UQCRX_QCR9 PF053650 100.00 Sarcolipin PF053661 -100.00 Phage_endo_I PF053679 0.39 NmrA PF053680 100.00 MtmB PF053690 100.00 DUF749 PF053700 100.00 Delta_lysin PF053720 100.00 Pro_3_hydrox_C PF053733 -0.19 Pacifastin_I PF05375

19 -0.30 FlaC_arch PF053771 -100.00 Hydant_A_N PF053780 100.00 Peptidase_C23 PF053790 100.00 Peptidase_A17 PF053800 100.00 Peptidase_C21 PF053810 100.00 Amidase_5 PF053825 -0.19 La PF05383

Sheet1

0 100.00 DegS PF053840 100.00 Adeno_E4 PF053850 100.00 TEP1_N PF053864 -100.00 Chorion_3 PF053870 100.00 Carbpep_Y_N PF053880 100.00 MecA PF053890 100.00 KRE9 PF053902 -0.19 Lsm_interact PF053910 100.00 COX7B PF053924 -0.88 Hum_adeno_E3A PF053930 100.00 AvrB_AvrC PF053940 100.00 DARPP-32 PF053951 -100.00 Phage_T7_Capsid PF053960 100.00 Med15_fungi PF053970 100.00 PufQ PF053980 100.00 EVI2A PF053990 100.00 FliT PF054005 -0.19 NodS PF054011 -0.19 TRAP-delta PF054047 -1.44 Mt_ATP-synt_B PF054050 100.00 WGR PF054060 100.00 Peptidase_C32 PF054111 -100.00 Peptidase_C33 PF054120 100.00 Peptidase_C34 PF054130 100.00 DUF1717 PF054140 100.00 Peptidase_C36 PF054151 -0.19 Peptidase_C37 PF054161 -0.19 GUN4 PF054191 -100.00 BCSC_C PF054201 -100.00 DUF751 PF054212 -100.00 SIN1 PF054220 100.00 Mycobact_memb PF054231 -100.00 Duffy_binding PF054242 -0.88 CopD PF054250 100.00 Alginate_lyase PF054261 -0.19 FIBP PF054271 -0.19 CRF-BP PF054285 -0.41 BSP_II PF054322 -100.00 Rick_17kDa_Anti PF054331 1.20 Tmemb_9 PF054341 -100.00 Phi-29_GP3 PF054350 100.00 AzlD PF054371 -100.00 TRH PF054382 -0.88 JTB PF054391 -0.19 MtrB PF054400 100.00 Micro_A_star PF054411 -100.00 Microvirus_A PF054422 0.73 ROS_MUCR PF05443

10 -100.00 DUF753 PF0544410 -0.70 Pox_ser-thr_kin PF054453 -1.29 AXE1 PF054482 0.51 Nicastrin PF054500 100.00 Phytoreo_Pns PF054511 -100.00 Toxin_6 PF054531 0.91 DAG1 PF054541 0.91 eIF_4EBP PF054564 -1.57 Siva PF05458

Sheet1

1 -100.00 Herpes_UL69 PF054597 -0.75 ORC6 PF054601 -100.00 ApoL PF054612 -0.19 Dicty_CAR PF054620 100.00 Sclerostin PF054630 100.00 Phi-29_GP4 PF054641 -100.00 Halo_GVPC PF054651 -100.00 BASP1 PF054660 100.00 Herpes_U47 PF054674 0.37 eIF-3c_N PF054700 100.00 Ter PF054726 -0.88 Herpes_UL45 PF054730 100.00 Chlam_vir PF054750 100.00 PET122 PF054761 -0.19 SURF2 PF054779 -0.08 Prominin PF054781 -100.00 PsaN PF054796 -1.98 Myco_19_kDa PF054812 -0.88 Serendipity_A PF054820 100.00 LRV_FeS PF05484

10 1.46 THAP PF054851 -0.19 SRP9-21 PF054861 -100.00 PAAR_motif PF054882 -100.00 Phage_tail_X PF054895 -100.00 ATP_synt_H PF054930 100.00 Tol_Tol_Ttg2 PF05494

16 -0.47 zf-CHY PF0549542 -0.31 RuvB_N PF054968 -1.17 Destabilase PF054971 -100.00 RALF PF054981 0.51 DMAP1 PF054996 -1.29 DUF755 PF055012 0.22 Dynactin_p62 PF055021 -0.19 Spore_GerAC PF055044 -1.57 Ebola_NP PF055050 100.00 DUF756 PF055060 100.00 Ran-binding PF055080 100.00 TraY PF055097 -1.44 Sarcoglycan_2 PF055103 -1.29 ATP-synt_F6 PF055110 100.00 AWPM-19 PF055121 -100.00 TraA PF055130 100.00 HR_lesion PF055140 100.00 Viral_NABP PF055154 -0.47 p25-alpha PF055171 0.51 Totivirus_coat PF055182 -0.88 Phage_H_T_join PF055211 -100.00 FdtA PF055233 0.10 PEP-utilisers_N PF055241 -100.00 R_equi_Vir PF055261 0.51 DUF758 PF055271 -0.19 Coronavirus_5 PF055287 0.06 Bap31 PF05529

27 -0.31 NPV_P10 PF055310 100.00 CsbD PF055320 100.00 HicB PF055342 0.73 Neurochondrin PF05536

Sheet1

0 100.00 DUF759 PF055370 100.00 Campylo_MOMP PF055384 -100.00 Pneumo_att_G PF055391 -100.00 DUF760 PF055420 100.00 Peptidase_C47 PF055430 100.00 Pro_racemase PF055442 -0.88 FixQ PF055450 100.00 She9_MDM33 PF055462 -100.00 Peptidase_M11 PF055484 0.22 Allexi_40kDa PF055491 -0.19 TM_helix PF055524 -1.57 DUF761 PF055531 -100.00 Novirhabdo_Nv PF055541 -0.19 Calsarcin PF055564 0.37 MAD PF055572 -0.19 DUF763 PF055590 100.00 Bt_P21 PF055600 100.00 DUF764 PF055611 -100.00 SpvD PF055631 0.91 Auxin_repressed PF055644 -1.57 Sipho_Gp157 PF055650 100.00 Pox_vIL-18BP PF055666 -1.29 ASFV_J13L PF055681 -0.19 Peptidase_M56 PF055691 -0.19 DUF765 PF055701 -0.19 DUF766 PF055711 0.51 Peptidase_M43 PF055722 -100.00 NosL PF055730 100.00 Peptidase_S37 PF05576

11 -1.20 Peptidase_S28 PF055774 -1.57 Peptidase_S32 PF055790 100.00 Peptidase_S55 PF055800 100.00 MCP_N PF055813 -1.29 Peptidase_U57 PF055820 100.00 Sulfolobus_pRN PF055840 100.00 DUF1758 PF055851 -100.00 Ant_C PF055861 -100.00 Anth_Ig PF055870 100.00 Botulinum_HA-17 PF055881 -0.19 DUF768 PF055890 100.00 DUF769 PF055900 100.00 DUF770 PF055911 -0.19 Bac_rhamnosid PF055923 -0.59 RHS_repeat PF055930 100.00 DUF771 PF055952 -0.88 Taeniidae_ag PF055962 -0.88 Phasin PF055971 -100.00 DUF772 PF055981 0.51 DUF773 PF056003 0.10 CLPTM1 PF056026 -1.29 DUF775 PF056031 -100.00 DUF776 PF05604

13 -0.27 Di19 PF056050 100.00 DUF777 PF056061 1.20 DUF778 PF056082 -0.88 LAP1C PF056091 -100.00 DUF780 PF05611

Sheet1

0 100.00 DUF781 PF056120 100.00 Herpes_U15 PF056130 100.00 DUF782 PF056145 - THOC7 PF056151 -0.19 Neisseria_TspB PF056160 100.00 DUF784 PF056172 -0.88 DUF787 PF056194 -1.57 DUF788 PF056201 -100.00 TniB PF056214 0.04 HOOK PF056220 100.00 LSR PF056242 -0.19 PAXNEB PF056250 100.00 Borrelia_P13 PF056280 100.00 NPP1 PF056301 -100.00 DUF791 PF056310 100.00 DUF792 PF056321 -100.00 DUF793 PF056330 100.00 DUF794 PF056340 100.00 Ribosomal_S23p PF056350 100.00 DUF795 PF056360 100.00 Glyco_transf_34 PF056370 100.00 Pup PF056392 -0.88 NKAIN PF056403 0.51 Agenet PF05641

27 -0.39 Sporozoite_P67 PF056421 -0.19 DUF800 PF056441 -100.00 RNA_pol_Rpc82 PF056450 100.00 DUF801 PF056473 -0.19 PEX11 PF05648

26 -0.45 Peptidase_M13_N PF056491 -0.19 DUF802 PF056501 -0.19 DcpS PF056521 -0.19 DUF803 PF056530 100.00 AvrD PF056552 -0.88 DUF805 PF056563 -100.00 RPW8 PF056590 100.00 DUF807 PF056600 100.00 DUF808 PF056610 100.00 HIM PF056620 100.00 DUF809 PF056631 -100.00 DUF810 PF056640 100.00 DUF811 PF056650 100.00 Fels1 PF05666

11 -0.79 DUF812 PF056673 -0.59 Med31 PF056692 -0.19 DUF814 PF056700 100.00 GETHR PF056711 0.51 MAP7 PF05672

47 -0.74 DUF815 PF056730 100.00 DUF816 PF056741 -100.00 NDUF_B7 PF056762 -0.88 DUF818 PF056773 -0.59 CHGN PF056792 -0.88 ATP-synt_E PF056801 -100.00 Fumerase PF056810 100.00 Fumerase_C PF056832 -100.00 DUF819 PF05684

Sheet1

2 -0.88 DUF821 PF056861 0.51 DUF822 PF056870 100.00 DUF824 PF056880 100.00 DUF823 PF056893 -0.19 ThiG PF056900 100.00 Raffinose_syn PF056911 -100.00 Myco_haema PF056921 0.91 Glycogen_syn PF056931 -0.19 SBP56 PF056940 100.00 DUF825 PF056950 100.00 DUF826 PF056960 100.00 Trigger_C PF056981 3.82 hATC PF056991 -0.19 BCAS2 PF057007 0.17 DUF827 PF057011 -0.19 Herpes_UL49_5 PF057020 100.00 DUF828 PF057032 -0.19 Caps_synth PF057043 -0.59 DUF829 PF057051 -100.00 CDKN3 PF057062 0.73 Zot PF057070 100.00 DUF830 PF057080 100.00 Sipho_tail PF057090 100.00 Coiled PF057102 0.51 MRG PF057120 100.00 MobC PF057131 -0.19 Borrelia_lipo_1 PF057142 -0.88 zf-piccolo PF057150 100.00 AKAP_110 PF057161 0.51 GPP34 PF057190 100.00 Dicty_CAD PF057201 0.51 PhyH PF057215 -1.10 TPMT PF057244 -0.19 FNIP PF057251 -0.19 UPF0228 PF057271 1.42 UPF0227 PF05728

92 -0.48 NACHT PF057291 -100.00 CFEM PF057300 100.00 TROVE PF057310 100.00 RepL PF057320 100.00 Tenui_N PF057330 100.00 TSP_C PF057350 100.00 Collagen_bind PF057372 -0.88 Cna_B PF05738

16 -0.39 SNARE PF057391 0.91 zf-nanos PF057412 -0.88 DUF833 PF05742

13 -1.14 UEV PF057431 0.51 CRPA PF057455 -1.10 DALR_1 PF057460 100.00 Rubella_E1 PF057480 100.00 Rubella_E2 PF057491 -100.00 Rubella_Capsid PF057501 -100.00 FixH PF057512 -100.00 Calici_MSP PF057521 -0.19 TRAP_beta PF057530 100.00 REF PF05755

Sheet1

1 -100.00 S-antigen PF057562 -0.19 PsbQ PF05757

23 -0.28 Ycf1 PF057583 -1.29 IER PF057605 -0.41 5_nucleotid PF057613 -0.59 VWA_CoxE PF057622 0.22 DUF835 PF057639 -1.29 YL1 PF057641 -100.00 NinG PF057662 0.22 Pox_A14 PF057679 -0.77 DUF836 PF057685 -1.10 DUF837 PF057690 100.00 Ins134_P3_kin PF057700 100.00 Pox_A31 PF057710 100.00 NinB PF05772

26 -0.35 RWD PF057730 100.00 Herpes_heli_pri PF057740 100.00 AfaD PF057750 100.00 Papilloma_E5A PF057762 -100.00 Acp26Ab PF057770 100.00 Apo-CIII PF057780 100.00 MRVI1 PF057811 -100.00 ECM1 PF057827 -0.75 DLIC PF057831 -100.00 Herpes_UL82_83 PF057841 -0.19 CNF1 PF057851 0.51 Barren PF05786

12 -0.03 C2-set PF057905 0.51 Bacillus_HBL PF057911 -100.00 Candida_ALS PF057925 0.40 TFIIF_alpha PF057932 -0.88 Tcp11 PF05794

16 -2.96 Plasmodium_Vir PF057951 -100.00 Chordopox_G2 PF057962 -100.00 Rep_4 PF057970 100.00 Phage_FRD3 PF057981 -0.19 COX5C PF057990 100.00 GvpO PF058000 100.00 DUF840 PF058010 100.00 EspB PF058020 100.00 Chordopox_L2 PF058036 -0.19 KAP PF058040 100.00 L6_membrane PF058052 -0.88 Noggin PF058066 -0.03 Podoplanin PF058082 0.22 NinF PF058105 -0.70 DUF842 PF058114 -1.57 Herpes_BLRF2 PF058120 100.00 Orthopox_F7 PF058134 -0.47 DUF843 PF058140 100.00 DUF844 PF058151 -0.19 TelA PF058161 -0.19 Ribophorin_II PF058171 -100.00 TraT PF058180 100.00 DUF845 PF058201 -100.00 NDUF_B8 PF058211 0.91 UMPH-1 PF05822

Sheet1

2 0.51 Gp-FAR-1 PF058231 -100.00 Pro-MCH PF058241 -0.19 PSP94 PF058256 -0.19 Phospholip_A2_2 PF058262 -100.00 ATP-synt_S1 PF058270 100.00 Adeno_PX PF058290 100.00 NodZ PF058302 -100.00 GAGE PF058311 -0.19 DUF846 PF058325 -1.10 FbpA PF05833

33 0.03 Lycopene_cycl PF058341 -0.19 Synaphin PF058351 -100.00 Chorion_S16 PF058361 0.51 CENP-H PF058371 0.51 Apc13p PF058390 100.00 Euplotes_phero PF05842

35 -0.25 Suf PF058430 100.00 YopD PF058441 -100.00 PhnH PF058450 100.00 Chordopox_A15 PF058460 100.00 L-fibroin PF058490 100.00 Lentivirus_VIF PF058514 -0.88 DUF848 PF058520 100.00 MC1 PF058542 0.22 ARPC4 PF058560 100.00 TraX PF058570 100.00 BIV_Env PF058581 -100.00 Mis12 PF058590 100.00 Haemagg_act PF058600 100.00 PhnI PF058612 0.51 Chordopox_RPO7 PF058640 100.00 RusA PF058660 100.00 DUF851 PF058671 -100.00 Rotavirus_VP7 PF058680 100.00 Dam PF058690 100.00 PA_decarbox PF058701 0.51 ESCRT-II PF058716 -0.37 DUF853 PF058723 -1.29 Mt_ATP-synt_D PF058731 0.51 PBAN PF058742 -0.19 aPHC PF058752 0.91 Terminase_GpA PF058764 -100.00 Phyto_Pns9_10 PF058782 -100.00 RHD3 PF058790 100.00 CNPase PF058813 -1.29 Baculo_RING PF058831 -100.00 ZYG-11_interact PF058840 100.00 Orthopox_F8 PF05886

13 -1.37 Trypan_PARP PF058877 -0.75 SLA_LP_auto_ag PF058891 0.51 Ebp2 PF058901 0.51 Hydroxy-O-Methy PF058910 100.00 Tricho_coat PF058920 100.00 LuxC PF058930 100.00 DUF859 PF058952 -0.88 NQRA PF058960 100.00 Cupin_3 PF05899

Sheet1

1 -0.19 Excalibur PF059011 -0.19 4_1_CTD PF059022 -0.19 DUF862 PF059030 100.00 DUF865 PF059064 -0.88 DUF866 PF059070 100.00 DUF868 PF059105 0.51 DUF869 PF059110 100.00 DUF870 PF059121 -0.19 RIB43A PF059149 -0.77 DUF872 PF059154 0.04 Sld5 PF059160 100.00 DUF874 PF059177 -2.13 API5 PF059180 100.00 Mitovir_RNA_pol PF05919

10 -0.70 Coprinus_mating PF059201 -100.00 Inhibitor_I9 PF059222 0.51 APC_crr PF059230 100.00 SAMP PF059240 100.00 Phage_GPL PF059260 100.00 Penaeidin PF059271 -0.19 Zea_mays_MuDR PF059282 0.22 Phage_GPO PF059290 100.00 Phage_AlpA PF059300 100.00 AgrD PF059310 100.00 Fun_ATP-synt_8 PF059331 -0.19 MCLC PF059340 100.00 Arylsulfotrans PF059350 100.00 DUF876 PF059360 100.00 Phage_min_tail PF059390 100.00 Chordopox_A20R PF059410 100.00 TcpA PF059460 100.00 DUF881 PF059490 100.00 Orthopox_A36R PF059501 -100.00 Peptidase_M15_2 PF059511 1.20 ComX PF059521 0.51 Allatostatin PF059531 -100.00 Phage_GPD PF05954

23 -2.23 Herpes_gp2 PF059550 100.00 APC_basic PF05956

13 -0.55 DUF883 PF059574 0.51 tRNA_U5-meth_tr PF059580 100.00 DUF884 PF059593 -100.00 DUF885 PF059603 -0.59 Chordopox_A13L PF059610 100.00 HutD PF059623 0.32 FYRN PF059644 -0.47 FYRC PF059652 -100.00 Chordopox_A33R PF059661 -100.00 Bacillus_PapR PF059681 -100.00 DUF889 PF059702 -0.88 Methyltransf_10 PF059712 -0.19 APC_15aa PF059720 100.00 Gp49 PF059730 100.00 DUF892 PF059740 100.00 EcsB PF059755 -1.10 DUF894 PF059777 -0.19 UNC-93 PF05978

Sheet1

0 100.00 DUF896 PF059791 -100.00 Toxin_7 PF059800 100.00 DUF897 PF059821 0.51 Med7 PF059832 -100.00 Cytomega_UL20A PF059844 0.04 ADAM_spacer1 PF059860 100.00 DUF898 PF059870 100.00 DUF899 PF05988

17 -0.72 DUF900 PF059900 100.00 DUF901 PF059911 -0.19 FragX_IP PF059941 -0.19 CDO_I PF059950 100.00 Fe_bilin_red PF059961 -0.19 Nop52 PF059970 100.00 Herpes_U5 PF059991 -100.00 DUF902 PF060010 100.00 CST-I PF060029 -1.00 SMN PF060031 -100.00 DUF903 PF06004

15 0.15 DUF904 PF060050 100.00 PhnJ PF060074 -0.19 Laminin_I PF06008

25 -0.52 Laminin_II PF060092 0.22 TRP PF060113 -0.59 DUF908 PF060127 0.35 WXG100 PF060130 100.00 DUF910 PF060140 100.00 Chordopox_A30L PF060153 0.10 Myosin_TH1 PF060170 100.00 CodY PF060181 -100.00 Phage_30_8 PF060192 -0.19 Roughex PF060201 -100.00 Gly_acyl_tr_N PF060210 100.00 Cir_Bir_Yir PF060220 100.00 DUF911 PF06023

20 -0.19 DUF912 PF060241 0.51 DUF913 PF060252 -0.88 Rib_5-P_isom_A PF060262 0.51 DUF914 PF06027

11 -0.64 DUF915 PF060281 -100.00 AlkA_N PF060291 -100.00 DUF916 PF060302 0.22 SERTA PF060310 100.00 DUF918 PF060330 100.00 DUF920 PF060350 100.00 DUF922 PF060372 -0.88 Mqo PF060390 100.00 Adeno_E3 PF060400 100.00 DUF924 PF060410 100.00 DUF925 PF060422 -100.00 DRP PF060441 -0.19 Sec6 PF060461 -0.19 SynMuv_product PF060472 -100.00 DUF927 PF060481 -0.19 HGD-D PF060500 100.00 DUF928 PF060510 100.00 DUF929 PF06053

Sheet1

0 100.00 CoiA PF060541 -0.19 ExoD PF060551 1.20 Terminase_5 PF060561 -0.19 VirJ PF060571 -100.00 DCP1 PF060581 -100.00 DUF930 PF060590 100.00 Mesothelin PF060600 100.00 Baculo_ME53 PF060610 100.00 UPF0231 PF060620 100.00 DUF932 PF06067

36 -0.55 TIP49 PF060681 0.51 PerC PF060692 -100.00 Herpes_UL32 PF060702 -0.88 YchF-GTPase_C PF060715 - Herpes_US9 PF060723 -100.00 DUF935 PF060742 -0.88 DUF936 PF060750 100.00 DUF937 PF060781 -0.19 Apyrase PF060792 -0.19 DUF938 PF060800 100.00 DUF939 PF060810 100.00 DUF940 PF060821 0.51 IL17 PF060831 0.51 Cytomega_TRL10 PF060843 -1.29 Rz1 PF060853 -1.29 Tyr-DNA_phospho PF060872 0.22 TLP-20 PF060881 0.51 Ins_P5_2-kin PF060900 100.00 DUF943 PF060923 -0.59 Spt4 PF060934 -1.57 AIG2 PF060940 100.00 Baculo_8kDa PF060961 -100.00 DUF945 PF060971 -0.19 Radial_spoke_3 PF060980 100.00 Strep_67kDa_ant PF061001 -100.00 DUF946 PF061011 0.51 DUF947 PF06102

27 -0.31 DUF948 PF061031 -100.00 Aph-1 PF061050 100.00 DUF951 PF061073 -0.19 DUF953 PF061105 -0.41 Herpes_capsid PF061120 100.00 BRE PF061131 0.51 DUF955 PF061144 -100.00 DUF956 PF061150 100.00 RinB PF061161 -0.19 DUF957 PF061172 0.22 NIDO PF061190 100.00 DUF959 PF061211 -100.00 TraH PF061220 100.00 CreD PF061230 100.00 DUF960 PF061240 100.00 Herpes_LAMP2 PF061260 100.00 DUF962 PF061273 -0.19 Shigella_OspC PF061281 -100.00 DUF963 PF061313 0.10 DUF964 PF06133

Sheet1

0 100.00 DUF965 PF061356 -0.19 DUF966 PF061360 100.00 BphX PF061391 -100.00 Ifi-6-16 PF061404 0.37 Baculo_11_kDa PF061434 -0.19 DNA_pol3_delta PF061441 -100.00 Corona_NS1 PF061450 100.00 DUF968 PF06147

14 -0.05 COG2 PF061481 -0.19 ChaB PF06150

15 -0.95 Trehalose_recp PF061511 -100.00 Phage_min_cap2 PF061520 100.00 DUF970 PF061534 -100.00 DUF971 PF06155

36 -0.06 DUF972 PF061561 0.51 DUF973 PF061571 -100.00 Phage_E PF061581 -100.00 DUF974 PF061596 -0.59 EzrA PF061601 -0.19 DUF975 PF061611 -0.19 DUF976 PF061621 -0.19 DUF977 PF061630 100.00 Glyco_transf_36 PF061650 100.00 MtfA PF061670 100.00 DUF981 PF061680 100.00 DUF982 PF061690 100.00 DUF983 PF061700 100.00 Cupin_5 PF061722 -0.88 WaaY PF061761 -100.00 QueT PF061771 -100.00 KdgM PF061783 -1.29 Med22 PF061790 100.00 CbiK PF061801 0.51 DinI PF061831 -100.00 YecM PF061850 100.00 HrpE PF061880 100.00 5-nucleotidase PF061890 100.00 Orthopox_A5L PF061931 -0.19 Phage_Orf51 PF061942 -100.00 DUF996 PF061953 -0.59 DUF997 PF061962 -0.88 DUF998 PF061970 100.00 DUF999 PF061980 100.00 Phage_tail_2 PF061990 100.00 tify PF062003 -100.00 PITH PF062015 -1.10 GDE_C PF062020 100.00 CCT PF062032 0.51 CBM_X PF062040 100.00 CpeT PF062060 100.00 DUF1002 PF062071 -100.00 COBRA1 PF062093 -1.29 DUF1003 PF062101 -0.19 BAMBI PF062111 0.51 GRIM-19 PF062128 -0.07 CobT PF062130 100.00 SLAM PF06214

Sheet1

2 -0.19 RTBV_P46 PF062166 -0.59 GAGA_bind PF062172 -0.19 NPR2 PF06218

11 -0.28 zf-U1 PF062203 0.10 zf-C2HC5 PF062211 -100.00 Phage_TAC PF062220 100.00 Phage_tail_T PF062230 100.00 DUF1007 PF062260 100.00 Orthopox_N1 PF062273 0.10 FRG1 PF062290 100.00 DUF1009 PF062300 100.00 DUF1010 PF062310 100.00 ATS3 PF062321 -100.00 TmoB PF062340 100.00 MelC1 PF062362 -100.00 DUF1011 PF062372 -100.00 Borrelia_lipo_2 PF062382 -0.19 ECSIT PF062391 -0.19 COXG PF062400 100.00 DUF1012 PF062410 100.00 DUF1013 PF062421 -0.19 DUF1014 PF062441 -0.19 Isy1 PF062461 1.42 Plasmod_Pvs28 PF062472 -0.19 Zw10 PF062480 100.00 EutQ PF062491 -100.00 DUF1017 PF062513 -100.00 DUF1018 PF062520 100.00 MTTB PF062530 100.00 DUF1019 PF062541 -100.00 DUF1020 PF062550 100.00 Nucleo_LEF-12 PF062560 100.00 DUF1021 PF062570 100.00 DUF1022 PF062580 100.00 DUF1023 PF062591 -100.00 DUF1024 PF062601 0.51 LktC PF062610 100.00 DUF1025 PF062621 -100.00 DUF1027 PF062651 -100.00 HrpF PF062663 -0.59 Fascin PF062680 100.00 DUF1030 PF062701 -0.19 RDD PF062711 -100.00 eIF-4B PF062730 100.00 DUF1031 PF062751 -100.00 FhuF PF062760 100.00 EutA PF062773 -1.29 DUF1032 PF062781 -100.00 DUF1033 PF062790 100.00 DUF1034 PF062800 100.00 DUF1036 PF062820 100.00 Cytomega_UL84 PF062840 100.00 DUF1039 PF062870 100.00 DUF1040 PF062880 100.00 FlbD PF062892 -0.19 DUF1041 PF06292

76 -0.23 Kdo PF06293

Sheet1

2 -0.88 DUF1042 PF062942 -0.88 DUF1043 PF062954 -0.88 PET PF062970 100.00 PsbY PF062981 -100.00 DUF1045 PF062991 -100.00 Lambda_Kil PF063010 100.00 MatP PF063031 0.51 DUF1048 PF06304

10 -0.70 DUF1049 PF063050 100.00 Herpes_IR6 PF063072 0.22 Torsin PF063091 0.51 NumbF PF063110 100.00 Neurexophilin PF063124 -100.00 ACP53EA PF063130 100.00 DUF1052 PF063192 0.51 GCN5L1 PF063200 100.00 Phage_NinH PF063221 -100.00 Phage_antiter_Q PF063232 0.22 Pigment_DH PF06324

27 -0.54 PrmA PF063254 0.22 DUF1053 PF063273 -100.00 Lep_receptor_Ig PF063280 100.00 TRI5 PF063300 100.00 Tbf5 PF063317 -2.13 Med13_C PF063330 100.00 Orthopox_A47 PF063340 100.00 DUF1054 PF063352 -0.19 DUSP PF063370 100.00 ComK PF063380 100.00 Ectoine_synth PF063391 -0.19 DUF1056 PF063413 -100.00 DUF1057 PF063420 100.00 Parecho_VpG PF063442 -0.88 Drf_DAD PF063450 100.00 Drf_FH1 PF063461 -100.00 SH3_4 PF063472 -100.00 DUF1059 PF063482 -0.88 HSL_N PF063501 -0.19 DUF1062 PF063531 -0.19 DUF1064 PF063560 100.00 Omega-toxin PF063572 -100.00 DUF1065 PF063580 100.00 Picorna_P3A PF063631 -0.19 DUF1068 PF063643 0.51 CD34_antigen PF063656 -0.19 Drf_FH3 PF063670 100.00 Anemone_cytotox PF063696 -0.88 Drf_GBD PF063711 -0.19 Gemin6 PF063721 0.91 CART PF063731 -0.19 NDUF_C2 PF06374

17 -1.07 BLVR PF063751 -100.00 DUF1070 PF063761 0.91 Adipokin_hormo PF063771 -100.00 RhaT PF063792 -100.00 DUF1072 PF063808 -100.00 DUF1074 PF06382

Sheet1

0 100.00 ICAT PF063841 -100.00 Baculo_LEF-11 PF063851 -100.00 GvpL_GvpF PF063860 100.00 Calcyon PF063871 -0.19 DUF1075 PF063880 100.00 NESP55 PF063901 0.51 MAT1 PF063910 100.00 Asr PF063921 -100.00 BID PF063932 -0.88 Pepsin-I3 PF063944 -0.88 CDC24 PF063951 -0.19 AGTRAP PF063967 -0.19 Desulfoferrod_N PF063975 -1.10 Pex24p PF063983 -0.59 GFRP PF063991 -0.19 Alpha-2-MRAP_N PF064002 -0.19 Alpha-2-MRAP_C PF064010 100.00 Lamprin PF064030 100.00 PSK PF064040 100.00 RCC_reductase PF064058 -1.57 StbA PF064061 -0.19 BDV_P40 PF064070 100.00 NPIP PF064090 100.00 HdeA PF064111 -100.00 TraD PF064122 -0.88 Neugrin PF06413

92 -0.80 Zeta_toxin PF064140 100.00 iPGM_N PF064152 -0.88 DUF1077 PF064170 100.00 CTP_synth_N PF064181 0.91 COG6 PF064190 100.00 Mgm101p PF064201 -0.19 LepA_C PF064212 -100.00 PDR_CDR PF064224 -1.57 GWT1 PF064233 0.32 PRP1_N PF064240 100.00 SATase_N PF064261 -0.19 UDP-g_GGTase PF064272 0.91 Sec2p PF064281 -100.00 L_lactis_RepB_C PF064301 -100.00 Polyoma_lg_T_C PF064311 0.51 GPI2 PF064322 -0.88 Me-amine-dh_H PF064330 100.00 DUF1079 PF064350 100.00 Pneumovirus_M2 PF064360 100.00 ISN1 PF064371 -0.19 DUF1080 PF064390 100.00 DNA_pol3_theta PF064404 0.04 EHN PF064410 100.00 DHFR_2 PF064422 -100.00 NADH_dehy_S2_C PF064445 -1.80 Hepcidin PF064462 -0.19 DUF1081 PF064480 100.00 DUF1082 PF064490 100.00 Moricin PF064511 -100.00 DUF1083 PF064521 -100.00 LT-IIB PF06453

Sheet1

1 -100.00 DUF1084 PF064542 -100.00 NADH5_C PF064554 -0.19 Arfaptin PF064561 -100.00 Ectatomin PF06457

13 -0.11 RR_TM4-6 PF064591 -0.19 NSP13 PF064601 -0.19 DUF1086 PF064611 -0.19 Hyd_WA PF064621 -0.19 Mob_synth_C PF064631 -0.19 DMAP_binding PF064642 -100.00 DUF1087 PF064652 -0.19 PCAF_N PF06466

19 -0.14 zf-FCS PF064675 -0.41 Spond_N PF064681 -0.19 DUF1088 PF064695 0.15 SMC_hinge PF064701 -100.00 NSP11 PF064714 0.04 ABC_membrane_2 PF064725 -1.80 MLTD_N PF064740 100.00 DUF1089 PF064754 0.04 DUF1090 PF06476

15 -2.90 DUF1091 PF064771 0.51 Ribonuc_2-5A PF064793 0.10 FtsH_ext PF064801 -100.00 COX_ARM PF064812 -0.88 Endostatin PF064821 -0.19 SAP18 PF064870 100.00 Orthopox_A49R PF064891 -0.19 FleQ PF064900 100.00 DUF1094 PF064911 -100.00 DUF1096 PF064933 -0.19 Transformer PF064950 100.00 DUF1098 PF064971 0.91 DUF1100 PF065000 100.00 Equine_IAV_S2 PF065020 100.00 DUF1101 PF065030 100.00 RepC PF065041 -100.00 XylR_N PF065051 -0.19 PrpR_N PF065061 -0.19 Auxin_resp PF065073 0.32 ExsB PF065086 -0.37 Na_trans_assoc PF065121 -100.00 DUF1103 PF065131 0.51 PsbU PF065140 100.00 NUP PF065160 100.00 DUF1104 PF065180 100.00 PAR1 PF065210 100.00 B12D PF065220 100.00 DUF1106 PF06523

14 -0.52 NOA36 PF065249 -1.69 SoxE PF065250 100.00 DUF1107 PF065260 100.00 Phage_P2_GpE PF065280 100.00 Vert_IL3-reg_TF PF065290 100.00 Phage_antitermQ PF065300 100.00 DUF1108 PF065311 -100.00 DUF1109 PF06532

Sheet1

0 100.00 DUF1110 PF065330 100.00 RGM_C PF065341 -100.00 RGM_N PF065351 -0.19 GMAP PF065401 -0.19 PHA-1 PF065420 100.00 Lac_bphage_repr PF065432 -0.19 DUF1115 PF065440 100.00 DUF1116 PF065452 -100.00 Vert_HS_TF PF065462 -0.88 DUF1117 PF065470 100.00 Kinesin-related PF065480 100.00 DUF1118 PF065491 -0.19 DUF1119 PF065501 -100.00 DUF1120 PF065512 -0.88 TOM20_plant PF065521 -0.19 BNIP3 PF065532 -0.88 Olfactory_mark PF065541 -0.19 ASFV_p27 PF065561 -100.00 DUF1122 PF065570 100.00 SecM PF065581 -0.19 GPI PF065602 -0.88 YhjQ PF065642 0.22 DUF1126 PF065650 100.00 Neural_ProG_Cyt PF065671 -0.19 DUF1127 PF065680 100.00 DUF1128 PF065695 - DUF1129 PF065700 100.00 Churchill PF065732 -0.19 FAD_syn PF065740 100.00 DUF1132 PF065750 100.00 DUF1133 PF065760 100.00 YscK PF065781 -100.00 Ly-6_related PF065791 -100.00 His_kinase PF065802 -100.00 DUF1135 PF065811 1.61 DUF1136 PF065823 -0.19 Neogenin_C PF065832 -0.19 DIRP PF06584

29 -0.03 JHBP PF065850 100.00 TraK PF065861 -0.19 Muskelin_N PF065880 100.00 Phage_T4_Ndd PF065911 -0.19 HCBP_related PF065940 100.00 BDV_P24 PF065950 100.00 PsbX PF065960 100.00 Chlorovi_GP_rpt PF065981 -100.00 DUF1139 PF065990 100.00 DUF1140 PF066000 100.00 Orthopox_F6 PF066016 -0.37 Myotub-related PF066020 100.00 DUF1141 PF066031 -0.19 Prokineticin PF066071 -100.00 DUF1143 PF066085 - TRI12 PF066090 100.00 DUF1144 PF066100 100.00 DUF1145 PF066110 100.00 DUF1146 PF06612

Sheet1

0 100.00 Neuromodulin PF066140 100.00 DUF1147 PF066151 -100.00 DUF1149 PF066190 100.00 DUF1150 PF066200 100.00 SIM_C PF066210 100.00 SepQ PF066221 -100.00 RAMP4 PF066241 -0.19 DUF1151 PF066252 -0.88 Catalase-rel PF066280 100.00 MipA PF066291 -0.19 DUF1154 PF066313 -1.29 XRCC4 PF066320 100.00 NolV PF066350 100.00 DUF1157 PF066360 100.00 PV-1 PF066372 -0.19 Strabismus PF066380 100.00 BAP PF066391 -0.19 P_C PF066400 100.00 DUF1158 PF066431 -100.00 ATP11 PF066443 -0.59 SPC12 PF066451 -100.00 Mycoplasma_p37 PF066461 -0.19 DUF1160 PF066480 100.00 DUF1161 PF066493 0.32 DUF1162 PF066501 -0.19 DUF1163 PF06651

14 -0.63 Methuselah_N PF066521 -100.00 DUF1164 PF066530 100.00 Tenui_PVC2 PF066560 100.00 DUF1167 PF066572 -0.88 DUF1168 PF066584 -0.88 C5-epim_C PF066621 -100.00 DUF1170 PF066632 -0.19 MIG-14_Wnt-bd PF066646 -0.59 PspB PF066670 100.00 ITI_HC_C PF066680 100.00 X_fast-SP_rel PF066690 100.00 Etmic-2 PF066700 100.00 DUF1175 PF066721 -0.19 L_lactis_ph-MCP PF066730 100.00 DUF1176 PF066740 100.00 DUF1178 PF066763 0.10 Auto_anti-p27 PF066772 -100.00 DUF1179 PF06678

16 -1.35 DUF1180 PF066790 100.00 DUF1182 PF06681

10 -0.88 DUF1183 PF066820 100.00 DUF1184 PF066830 100.00 SpoIIIAC PF066864 -0.88 SUR7 PF066872 -0.88 DUF1187 PF066884 -0.88 zf-C4_ClpX PF066890 100.00 DUF1188 PF066900 100.00 DUF1189 PF066910 100.00 MNSV_P7B PF066920 100.00 Plant_NMP1 PF066940 100.00 Sm_multidrug_ex PF06695

Sheet1

0 100.00 Strep_SA_rep PF066962 0.51 DUF1191 PF066974 0.22 DUF1192 PF066981 -100.00 PIG-F PF066994 -0.19 MIB_HERC2 PF067013 0.10 DUF1193 PF067021 0.91 SPC25 PF067031 -0.19 DspF PF067040 100.00 SF-assemblin PF067050 100.00 CTV_P6 PF067060 100.00 DUF1194 PF067070 100.00 DUF1195 PF067080 100.00 DUF1199 PF067122 -0.19 DUF1200 PF067130 100.00 Gp5_C PF067151 -100.00 DUF1201 PF067160 100.00 DUF1202 PF067170 100.00 Phi-29_GP16_7 PF06720

22 -1.08 MreB_Mbl PF067231 -0.19 DUF1206 PF067240 100.00 3D PF067251 -0.19 BC10 PF067260 100.00 DUF1207 PF067271 -0.19 PIG-U PF067282 0.22 DUF1208 PF067302 -0.19 Pescadillo_N PF067325 -0.19 DEAD_2 PF067330 100.00 UL97 PF067340 100.00 DUF1211 PF06736

10 -2.49 Transglycosylas PF067372 0.91 DUF1212 PF067384 -0.88 SBBP PF067392 -100.00 DUF1213 PF067403 -1.29 LsmAD PF067410 100.00 DUF1214 PF067423 -0.19 FAST_1 PF067430 100.00 DUF1215 PF06744

40 -0.35 KaiC PF067452 -100.00 DUF1216 PF06746

14 -0.63 CHCH PF067471 -100.00 DUF1217 PF067482 -100.00 DUF1218 PF067490 100.00 DiS_P_DiS PF067500 100.00 EutB PF067513 -100.00 E_Pc_C PF067521 -100.00 S19 PF067568 -0.32 Ins_allergen_rp PF067571 -100.00 DUF1220 PF067581 -100.00 DUF1221 PF067600 100.00 IcmF-related PF067610 100.00 DUF1222 PF067620 100.00 DUF1223 PF067641 -100.00 Hydrophobin_2 PF067660 100.00 Sif PF067670 100.00 Plasmid_Txe PF067692 -0.88 Arif-1 PF067702 0.22 Desmo_N PF06771

Sheet1

1 -100.00 LtrA PF067721 -0.19 Seipin PF067750 100.00 IalB PF067762 0.51 DUF1227 PF067770 100.00 Chlor_dismutase PF067786 0.22 DUF1228 PF067791 0.51 Erp_C PF067804 -0.88 UPF0233 PF067810 100.00 UPF0236 PF067822 -0.19 UPF0239 PF067832 -0.88 UPF0240 PF067843 -0.19 UPF0242 PF067851 -0.19 UPF0253 PF067860 100.00 UPF0254 PF067870 100.00 UPF0257 PF067881 -100.00 UPF0258 PF067890 100.00 UPF0259 PF067901 0.91 TMP_2 PF067911 -100.00 UPF0270 PF067941 -0.19 Erythrovirus_X PF067951 0.51 NapE PF067960 100.00 DUF1229 PF067970 100.00 PrkA PF067980 100.00 DUF1230 PF067990 100.00 DUF1231 PF068020 100.00 DUF1232 PF068030 100.00 Lipoprotein_18 PF068040 100.00 Lambda_tail_I PF068052 -0.19 Clp1 PF068070 100.00 DctM PF068082 -100.00 NPDC1 PF068094 0.73 Phage_GP20 PF068100 100.00 ImpA-rel_N PF068124 -0.88 Lung_7-TM_R PF068141 -0.19 RVT_connect PF068151 0.51 NOD PF068160 100.00 RVT_thumb PF068173 0.32 Fez1 PF068182 -0.19 Arc_PepC PF068190 100.00 Phage_fiber_C PF068205 -0.70 DUF1234 PF068210 100.00 DUF1236 PF068237 -0.05 HSBP1 PF068256 0.22 zf-FPG_IleRS PF068279 0.18 BiPBP_C PF068321 -0.19 MdcE PF068331 -100.00 TraU PF068340 100.00 DUF1240 PF068361 0.91 Fijivirus_P9-2 PF068371 -0.19 Alum_res PF068381 -0.19 zf-GRF PF068391 0.51 DUF1241 PF068400 100.00 Phage_T4_gp19 PF068412 -0.88 DUF1242 PF068422 -0.88 DUF1244 PF068441 -0.19 Arc_PepC_II PF068471 -100.00 DUF1246 PF06849

Sheet1

0 100.00 PHB_depo_C PF068501 0.51 DUF1248 PF068520 100.00 Phage_Gp15 PF068541 -0.19 DUF1250 PF068551 -100.00 DUF1251 PF068561 0.91 NOG1 PF068584 -0.88 Bin3 PF068591 -0.19 BALF1 PF068619 -0.30 DUF1253 PF068621 -100.00 DUF1254 PF068630 100.00 PAP_PilO PF068642 -0.19 DUF1256 PF068661 2.12 DUF1258 PF068691 0.51 RNA_pol_I_A49 PF068703 -100.00 TraH_2 PF068711 -0.19 PRF PF068750 100.00 SCRL PF068761 -0.19 DUF1260 PF068770 100.00 Pkip-1 PF068780 100.00 DUF1261 PF068790 100.00 DUF1262 PF068802 -0.88 Elongin_A PF068810 100.00 DUF1263 PF068821 -0.19 RNA_pol_Rpa2_4 PF068831 -100.00 DUF1264 PF068840 100.00 TPX2 PF068860 100.00 DUF1265 PF068872 0.22 Put_Phosphatase PF068883 -100.00 Phage_Mu_Gp45 PF068901 -100.00 Phage_CP76 PF068920 100.00 Phage_lambd_GpG PF068941 -0.19 DUF1267 PF068950 100.00 DUF1268 PF068961 -100.00 YqfD PF068980 100.00 DUF1270 PF069000 100.00 FrpC PF069010 100.00 DUF1271 PF069021 -0.19 FAIM1 PF069055 - DUF1272 PF069061 -100.00 DUF1273 PF069080 100.00 MEA1 PF069101 -100.00 Senescence PF069112 -100.00 DUF1275 PF069123 -0.19 DUF1279 PF069161 -100.00 Pectate_lyase_2 PF069170 100.00 DUF1280 PF069185 -0.19 Ded_cyto PF069200 100.00 CTV_P13 PF069220 100.00 GutM PF069230 100.00 DUF1281 PF069241 -100.00 MGDG_synth PF069250 100.00 Rep_Org_C PF069260 100.00 Rotavirus_VP3 PF069291 -100.00 DUF1282 PF069301 -100.00 Adeno_E4_ORF3 PF069310 100.00 DUF1283 PF06932

28 -0.81 SSP160 PF06933

Sheet1

1 -0.19 DUF1284 PF069350 100.00 Selenoprotein_S PF069360 100.00 EURL PF069370 100.00 DUF1285 PF069380 100.00 DUF1286 PF069390 100.00 NT5C PF069410 100.00 GlpM PF069420 100.00 zf-LSD1 PF069430 100.00 DUF1289 PF069450 100.00 Phage_holin_5 PF069460 100.00 DUF1290 PF069470 100.00 DUF1292 PF069493 -0.19 PLA2G12 PF069510 100.00 Resistin PF069541 -100.00 XET_C PF069550 100.00 RtcR PF069561 0.51 COPI_C PF069571 -100.00 RecQ5 PF069590 100.00 DUF1294 PF069611 -100.00 rRNA_methylase PF069621 -100.00 FPN1 PF069630 100.00 Alpha-L-AF_C PF069643 -0.59 DUF1295 PF069661 0.51 Mo-nitro_C PF069671 -100.00 BATS PF069681 0.91 HemN_C PF069690 100.00 RepA_N PF069700 100.00 Put_DNA-bind_N PF069710 100.00 DUF1296 PF069720 100.00 DUF1297 PF069730 100.00 DUF1298 PF069741 -100.00 SdiA-regulated PF069772 -0.88 POP1 PF069781 0.51 DUF1301 PF069790 100.00 DUF1302 PF069801 0.51 MRP-L47 PF069840 100.00 HET PF069850 100.00 TraN PF069860 100.00 NifT PF069880 100.00 Gal-3-0_sulfotr PF069901 0.51 MFAP1_C PF069910 100.00 Phage_lambda_P PF069920 100.00 Phage_P2_GpU PF069950 100.00 DUF1305 PF069960 100.00 Suc_Fer-like PF069992 -0.88 DUF1308 PF070001 -0.19 BAT2_N PF070014 0.22 DUF1309 PF070040 100.00 DUF1310 PF070060 100.00 DUF1311 PF070071 -100.00 DUF1312 PF070090 100.00 Endomucin PF070100 100.00 DUF1313 PF070110 100.00 Curlin_rpt PF070121 -100.00 DUF1314 PF070132 -100.00 VirC1 PF070150 100.00 CRAM_rpt PF07016

Sheet1

2 -0.88 Rab5ip PF070198 0.04 MetW PF070210 100.00 Phage_CI_repr PF070221 -100.00 DUF1315 PF070231 -100.00 ImpE PF070240 100.00 DUF1318 PF070275 -100.00 DUF1319 PF070281 -100.00 CryBP1 PF070290 100.00 DUF1320 PF070300 100.00 DUF1322 PF070321 -100.00 Orthopox_B11R PF070331 0.91 ORC3_N PF070341 0.51 Mic1 PF070350 100.00 DUF1323 PF070370 100.00 DUF1324 PF070382 0.22 DUF1325 PF070390 100.00 DUF1327 PF070410 100.00 TrfA PF070420 100.00 DUF1329 PF070442 -100.00 DUF1330 PF070450 100.00 CRA_rpt PF070462 -0.19 OPA3 PF070470 100.00 DUF1331 PF070482 -0.19 OCIA PF070511 -0.19 Hep_59 PF070522 -100.00 Pericardin_rpt PF070540 100.00 Eno-Rase_FAD_bd PF070550 100.00 TraI PF070570 100.00 Myosin_HC-like PF070583 -1.29 Swi5 PF070614 -0.88 Clc-like PF070620 100.00 DUF1338 PF070631 -0.19 RIC1 PF070640 100.00 D123 PF070651 -100.00 DUF1340 PF070670 100.00 PRRSV_2b PF070692 -0.88 Spo0M PF070700 100.00 DUF1342 PF070720 100.00 ROF PF070731 1.20 TRAP-gamma PF070741 -0.19 DUF1343 PF070754 -100.00 DUF1344 PF070760 100.00 DUF1345 PF070770 100.00 FYTT PF070781 0.51 DUF1347 PF070791 -0.19 DUF1350 PF070821 -100.00 DUF1351 PF070832 -0.88 Spot_14 PF070841 -0.19 DUF1352 PF070860 100.00 DUF1353 PF070871 -0.19 GvpD PF070880 100.00 DUF1355 PF070904 -0.88 FmrO PF070910 100.00 DUF1356 PF070925 -0.41 SGT1 PF070930 100.00 IgaA PF070953 -0.59 DUF1358 PF07096

Sheet1

0 100.00 DUF1359 PF070974 0.62 DUF1360 PF070980 100.00 DUF1361 PF070990 100.00 ASRT PF071000 100.00 DUF1364 PF071021 -100.00 DUF1365 PF071030 100.00 DUF1366 PF071040 100.00 DUF1367 PF07105

14 -0.63 TBPIP PF071060 100.00 WI12 PF071070 100.00 PipA PF071081 -100.00 Mg-por_mtran_C PF071091 -100.00 EthD PF071101 -100.00 HCR PF071110 100.00 DUF1368 PF071121 -0.19 DUF1370 PF071140 100.00 DUF1371 PF071152 -100.00 DUF1374 PF071181 -100.00 DUF1375 PF071191 -100.00 DUF1376 PF071200 100.00 VLPT PF071221 -100.00 PsbW PF071230 100.00 Phytoreo_P8 PF071240 100.00 DUF1378 PF071252 1.07 Nodulin_late PF071270 100.00 DUF1380 PF071280 100.00 DUF1381 PF071291 -100.00 YebG PF071300 100.00 Merozoite_SPAM PF071330 100.00 DUF1383 PF071340 100.00 DUF1385 PF071361 -0.19 VDE PF071371 -0.19 DUF1387 PF071390 100.00 Phage_term_sma PF071411 -100.00 CrtC PF07143

12 -1.29 PAM2 PF071450 100.00 DUF1389 PF071462 -0.19 PDCD9 PF071472 -100.00 Pes-10 PF071490 100.00 DUF1390 PF071500 100.00 DUF1391 PF071511 0.51 Marek_SORF3 PF071530 100.00 DUF1392 PF071542 -100.00 DUF1393 PF071550 100.00 Prenylcys_lyase PF071561 -0.19 MatC_N PF071582 -0.19 DUF1394 PF071592 -0.88 DUF1395 PF071603 -0.59 B9 PF071620 100.00 Pex26 PF071634 -1.57 DUF1397 PF071650 100.00 DUF1398 PF071663 -1.29 FAE_3-kCoA_syn1 PF07168

17 -0.94 GRP PF071721 -100.00 DUF1399 PF071733 -100.00 FAP PF071742 -100.00 Osteoregulin PF07175

Sheet1

0 100.00 DUF1400 PF071763 -0.19 Neuralized PF071772 -100.00 TraL PF071780 100.00 DUF1401 PF071800 100.00 VirC2 PF071810 100.00 DUF1402 PF071821 -100.00 DUF1403 PF071830 100.00 CTV_P33 PF071841 -100.00 KSHV_K8 PF071881 -100.00 SF3b10 PF071891 -100.00 DUF1406 PF07190

10 -1.39 DUF1407 PF071911 0.51 SNURF PF071920 100.00 DUF1408 PF071930 100.00 P2 PF071941 1.42 FliD_C PF071950 100.00 DUF1409 PF071971 -100.00 DUF1410 PF071980 100.00 DUF1411 PF071995 -0.19 Mod_r PF072000 100.00 HrpJ PF072011 0.51 Tcp10_C PF072021 -100.00 DUF1412 PF072031 -0.19 Orthoreo_P10 PF072040 100.00 DUF1413 PF072050 100.00 Baculo_LEF-10 PF072060 100.00 Lir1 PF072070 100.00 DUF1414 PF072080 100.00 DUF1415 PF072090 100.00 DUF1416 PF072100 100.00 DAP10 PF072132 -100.00 DUF1418 PF072141 0.51 LcrG PF072160 100.00 Het-C PF072176 -0.03 RAP1 PF072185 0.15 HemY_N PF072191 -100.00 GlcNAc_2-epim PF072213 0.51 PBP_sp32 PF072220 100.00 DUF1421 PF072231 1.20 Chlorophyllase PF072241 -0.19 NDUF_B4 PF072251 -100.00 DUF1422 PF072260 100.00 DUF1423 PF072277 -0.75 SpoIIE PF072281 -100.00 VirE2 PF072291 -100.00 Hs1pro-1_N PF072310 100.00 DUF1424 PF072320 100.00 DUF1426 PF072341 -100.00 DUF1427 PF072352 -0.19 DUF1428 PF072378 -1.57 Turandot PF072400 100.00 DUF1430 PF072421 -100.00 Phlebovirus_G1 PF072430 100.00 Surf_Ag_VNR PF072440 100.00 Phlebovirus_G2 PF072454 -0.88 Phlebovirus_NSM PF072460 100.00 AATase PF07247

Sheet1

13 -100.00 DUF1431 PF072480 100.00 Cerato-platanin PF072491 -100.00 Glyoxal_oxid_N PF072500 100.00 Gypsy PF072530 100.00 DUF1434 PF072541 -100.00 Benyvirus_14KDa PF072550 100.00 DUF1435 PF072565 0.15 HCaRG PF072582 -100.00 ProSAAS PF072591 -100.00 DnaB_2 PF072612 -100.00 DMP1 PF072631 -0.19 EI24 PF072641 0.51 TAP35_44 PF072656 -0.19 Nucleo_P87 PF072670 100.00 EppA_BapA PF072683 -100.00 Cytadhesin_P30 PF072711 -100.00 DUF1439 PF072732 -0.19 DUF1440 PF072740 100.00 ArdA PF072750 100.00 SapC PF072771 -0.19 DUF1443 PF072800 100.00 INSIG PF072817 0.35 Transposase_35 PF072820 100.00 TrbH PF072831 -100.00 DUF1444 PF072850 100.00 DUF1445 PF072861 -0.19 DUF1446 PF072871 -100.00 DUF1447 PF072882 0.22 DUF1448 PF072890 100.00 DUF1449 PF072901 -100.00 MauE PF072915 - NID PF072920 100.00 DUF1450 PF072933 -1.29 DUF1451 PF072950 100.00 TraP PF072960 100.00 DPM2 PF072971 -100.00 NnrU PF072982 -100.00 FBP PF072991 -100.00 DUF1453 PF073010 100.00 AroM PF073028 -0.19 Occludin_ELL PF073032 -0.88 SRA1 PF073041 -100.00 DUF1454 PF073053 -1.29 DUF1456 PF073082 -100.00 FlaF PF073090 100.00 PAS_5 PF073101 -100.00 DUF1458 PF073110 100.00 DUF1460 PF073131 -100.00 DUF1461 PF073140 100.00 DUF1462 PF073150 100.00 DUF1463 PF073160 100.00 YcgR PF073172 -100.00 DnaI_N PF073195 -1.10 YscO PF073210 100.00 DUF1465 PF073232 -0.19 DGCR6 PF073240 100.00 Curto_V2 PF07325

Sheet1

1 -100.00 DUF1466 PF073260 100.00 Neuroparsin PF073270 100.00 VirD1 PF073282 -0.88 DUF1467 PF073300 100.00 DUF1468 PF07331

16 -1.35 DUF1469 PF073320 100.00 SLR1-BP PF073335 -0.70 IFP_35_N PF073341 0.91 DUF1470 PF073360 100.00 DUF1471 PF073381 -100.00 DUF1474 PF073421 -100.00 DUF1475 PF073432 -0.88 Amastin PF073440 100.00 DUF1476 PF073450 100.00 DUF1477 PF073463 -0.19 CI-B14_5a PF073470 100.00 DUF1478 PF073490 100.00 DUF1480 PF073512 0.51 Phage_Mu_Gam PF073521 -100.00 Uroplakin_II PF073539 -0.77 Sp38 PF073540 100.00 GRDB PF073550 100.00 DRAT PF073570 100.00 DUF1482 PF073583 -100.00 LEAP-2 PF073593 -0.19 Cytochrom_B562 PF073611 -100.00 CcdA PF073621 -100.00 DUF1484 PF073633 -1.29 Toxin_8 PF073651 -0.19 FB_lectin PF07367

10 -1.39 DUF1487 PF073680 100.00 DUF1488 PF073691 -100.00 DUF1490 PF073710 100.00 CAMP_factor PF073732 -0.88 DUF1492 PF073740 100.00 Tenui_PV2 PF073752 -0.19 DUF1493 PF073770 100.00 FlbT PF073780 100.00 Pneumo_M2 PF073800 100.00 DUF1495 PF073811 -0.19 HC2 PF073820 100.00 DUF1496 PF073831 -100.00 DUF1499 PF07386

18 -0.37 Seadorna_VP7 PF073870 100.00 DUF1500 PF073890 100.00 P30 PF073901 -0.19 Sec10 PF073931 0.51 DUF1501 PF073941 -100.00 Mig-14 PF073951 -100.00 DUF1502 PF073970 100.00 MDMPI_C PF073981 -100.00 IL11 PF074000 100.00 Lenti_VIF_2 PF074011 -100.00 TEBP_beta PF074040 100.00 DUF1506 PF074052 -0.88 NICE-3 PF074060 100.00 Seadorna_VP6 PF07407

Sheet1

1 -100.00 DUF1507 PF074081 -100.00 GP46 PF074091 -100.00 DUF1508 PF074111 0.51 Geminin PF074121 -0.19 Herpes_UL37_2 PF074133 -1.29 Herpes_LMP2 PF074150 100.00 Crinivirus_P26 PF074160 100.00 Crl PF074170 100.00 PCEMA1 PF074182 0.22 DUF1509 PF074200 100.00 s48_45 PF07422

24 -0.53 DUF1510 PF074230 100.00 TrbM PF074241 -0.19 Dynactin_p22 PF074260 100.00 Tri3 PF074280 100.00 PP1 PF074301 -100.00 DUF1512 PF074310 100.00 Hc1 PF074322 -0.88 DUF1513 PF074330 100.00 CblD PF074340 100.00 YycH PF074350 100.00 Curto_V3 PF074360 100.00 DUF1514 PF074388 -0.66 DUF1515 PF074391 -100.00 Caerin_1 PF074400 100.00 BofA PF074410 100.00 Ponericin PF074422 -0.88 HARP PF074430 100.00 Ycf66_N PF074441 -100.00 priB_priC PF074452 -100.00 GumN PF074460 100.00 VP40 PF074471 -100.00 Spp-24 PF074489 -0.77 HyaE PF074490 100.00 HycH PF074503 -1.29 SpoVAD PF074512 -0.88 CHRD PF074520 100.00 NUMOD1 PF074530 100.00 SpoIIP PF074541 -0.19 Psu PF074551 -100.00 Hpre_diP_synt_I PF074561 -100.00 DUF1516 PF074571 -100.00 SPAN-X PF074580 100.00 CTX_RstB PF074590 100.00 NUMOD3 PF07460

10 -1.80 MSP1_C PF074624 0.04 ApoLp-III PF074641 -100.00 PsaM PF074654 -100.00 DUF1517 PF074660 100.00 BLIP PF074671 -100.00 Agglutinin PF074681 -100.00 DUF1518 PF074692 0.51 Glyco_hydro_88 PF074701 -0.19 Phage_Nu1 PF074710 100.00 PA-IIL PF074720 100.00 Toxin_11 PF074731 -0.19 G2F PF07474

Sheet1

1 0.51 Hpr_kinase_C PF074752 -0.19 MAAL_C PF074760 100.00 Glyco_hydro_67C PF074776 -0.88 Dala_Dala_lig_C PF074783 -0.19 NAD_Gly3P_dh_C PF074794 -100.00 DUF1520 PF074801 -100.00 DUF1521 PF074810 100.00 DUF1522 PF074821 -100.00 DUF1529 PF074850 100.00 Glyco_hydro_67M PF074882 0.22 Tir_receptor_C PF074890 100.00 Tir_receptor_N PF074902 -0.88 PPI_Ypi1 PF074910 100.00 Trehalase_Ca-bi PF074925 -0.19 Reg_prop PF074947 0.17 Y_Y_Y PF074952 -0.19 zf-CW PF074961 -0.19 Rho_RNA_bind PF074971 -100.00 Rho_N PF074982 -0.88 RuvA_C PF074993 -0.19 TFIIS_M PF075000 100.00 G5 PF075011 -0.19 MANEC PF075023 -1.29 zf-HYPF PF075031 -0.19 FTP PF075041 -0.19 Gp37_Gp68 PF075051 -0.19 RepB PF075060 100.00 WavE PF075070 100.00 Recombinase PF075081 -100.00 DUF1524 PF075102 -0.88 DUF1525 PF075110 100.00 DUF1527 PF075130 100.00 DUF1528 PF075150 100.00 SecA_SW PF075162 -0.19 SecA_DEAD PF075171 -100.00 SrfB PF075205 -0.70 RMMBL PF075212 -100.00 DRMBL PF075221 -100.00 Big_3 PF07523

31 -2.52 Bromo_TP PF0752411 -0.51 SOCS_box PF075251 -0.19 POX PF07526

13 -0.81 Hairy_orange PF075272 -0.19 DZF PF075282 -0.19 HSA PF075290 100.00 PRE_C2HC PF075304 -0.47 TAFH PF075311 -0.19 Big_4 PF075323 0.10 BRK PF075335 -0.41 TLD PF075349 -0.44 zf-DBF PF075351 -0.19 HWE_HK PF075361 1.20 DRIM PF075391 0.51 NOC3p PF075401 -0.19 EIF_2_alpha PF075411 -0.19 ATP12 PF075425 -1.80 PGA2 PF07543

Sheet1

3 -1.29 Med9 PF075442 -100.00 Vg_Tdu PF075453 -1.29 EMI PF075461 -0.19 ChlamPMP_M PF075481 -100.00 Sec_GG PF075490 100.00 DUF1533 PF075500 100.00 DUF1534 PF075510 100.00 Coat_X PF075520 100.00 Lipoprotein_Ltp PF075530 100.00 FIVAR PF075541 -100.00 NAGidase PF075554 -1.57 Shugoshin_C PF075578 -1.57 Shugoshin_N PF075580 100.00 FlaE PF075590 100.00 DUF1539 PF075600 100.00 DUF1540 PF075612 0.51 NCD3G PF075621 -0.19 DUF1542 PF075648 0.30 Band_3_cyto PF075650 100.00 DUF1543 PF075662 -0.88 HisKA_2 PF075686 -0.37 Hira PF075695 -1.10 DUF1546 PF075711 -100.00 BCNT PF075723 -100.00 SMC_Nse1 PF075741 -0.19 Nucleopor_Nup85 PF075751 -0.19 BRAP2 PF075760 100.00 DUF1547 PF075770 100.00 LAB_N PF075780 100.00 DUF1548 PF075790 100.00 Glug PF075812 -100.00 AP_endonuc_2_N PF075821 -100.00 PSCyt2 PF075830 100.00 BatA PF075840 100.00 DUF1551 PF075851 0.51 HXXSHH PF075862 -100.00 PSD1 PF075871 -100.00 DUF1556 PF075901 -100.00 DUF1557 PF075910 100.00 Transposase_36 PF075920 100.00 UnbV_ASPIC PF075930 100.00 Planc_extracel PF075951 -100.00 SBP_bac_10 PF075961 -100.00 DUF1560 PF075970 100.00 DUF1564 PF076001 -100.00 DUF1562 PF076011 0.51 DUF1565 PF076020 100.00 DUF1567 PF076044 0.73 DUF1570 PF076071 -100.00 DUF1577 PF076140 100.00 DUF1579 PF076170 100.00 DUF1580 PF076181 -100.00 SLEI_Leptospira PF076200 100.00 DUF1582 PF076210 100.00 PEGSRP PF076230 100.00 PSD2 PF076241 -100.00 DUF1586 PF07625

Sheet1

2 -100.00 PSD3 PF076265 -100.00 PSCyt3 PF076270 100.00 DUF1590 PF076290 100.00 PSD4 PF076311 -0.19 DUF1593 PF076320 100.00 RtxA PF076340 100.00 PSRT PF076360 100.00 PSD5 PF076371 -100.00 Sigma70_ECF PF076381 -100.00 YTV PF076390 100.00 QPP PF07640

33 -0.22 EGF_CA PF0764518 -0.13 Kelch_2 PF0764634 -0.28 SAM_2 PF0764734 -0.82 Kazal_2 PF0764828 -0.96 C1_3 PF0764911 -0.10 KH_2 PF076504 0.04 ANTH PF076517 -0.52 Flavi_DEAD PF07652

60 -0.29 SH3_2 PF0765325 0.09 C1-set PF076542 -0.19 Secretin_N_2 PF076551 -100.00 KWG PF076562 0.51 MNNL PF076570 100.00 DUF1599 PF076590 100.00 STN PF076602 -0.88 MORN_2 PF076613 -1.29 Nucleos_tra2_C PF076621 -100.00 FeoB_C PF076641 -100.00 MpPF26 PF076660 100.00 DUF1600 PF076670 100.00 MpPF1 PF076680 100.00 Eco57I PF076692 0.22 Gate PF076700 100.00 DUF1601 PF076710 100.00 MFS_Mycoplasma PF076720 100.00 DUF1602 PF076730 100.00 Cleaved_Adhesin PF076758 0.13 PD40 PF076766 -0.37 A2M_recep PF076776 -0.37 A2M_comp PF07678

127 0.27 I-set PF076790 100.00 DoxA PF076800 100.00 DoxX PF076810 100.00 CobW_C PF076831 -0.19 NODP PF076841 -0.19 GATase_3 PF07685

124 0.06 V-set PF076868 -1.57 M20_dimer PF076870 100.00 KaiA PF076883 -100.00 KaiB PF07689

160 -0.50 MFS_1 PF0769012 -0.47 KAP_NTPase PF076936 -0.19 7TMR-DISM_7TM PF076950 100.00 7TMR-DISMED2 PF076960 100.00 7TMR-HDED PF076977 -0.34 GCC2_GCC3 PF07699

Sheet1

5 - HNOB PF0770015 -0.33 HNOBA PF077010 100.00 UTRA PF077027 -1.03 A2M_N_2 PF077030 100.00 PSK_trans_fac PF077044 -1.57 CARDB PF077050 100.00 TAT_ubiq PF07706

31 -0.44 BACK PF077071 -0.19 P53_tetramer PF077101 -100.00 RabGGT_insert PF077112 -0.88 DUF1604 PF07713

211 -0.30 Pkinase_Tyr PF077140 100.00 Plug PF07715

30 -0.15 bZIP_2 PF0771613 -0.67 DUF1605 PF077171 -0.19 Coatamer_beta_C PF07718

123 -0.20 TPR_2 PF077198 0.04 TPR_3 PF07720

18 -0.03 TPR_4 PF077214 -0.47 Peptidase_C26 PF077222 1.07 LRR_2 PF07723

33 -0.43 AAA_2 PF077248 -1.57 LRR_3 PF07725

30 -0.50 AAA_3 PF077260 100.00 RVT_2 PF07727

94 -0.29 AAA_5 PF077281 -0.19 FCD PF077294 -0.47 HisKA_3 PF077305 - Cu-oxidase_2 PF077314 0.22 Cu-oxidase_3 PF077321 -100.00 DNA_pol3_alpha PF077330 100.00 FBA_1 PF077340 100.00 FBA_2 PF077355 -0.41 Sad1_UNC PF077384 -100.00 TipAS PF077391 1.20 Toxin_12 PF077404 -0.47 BRF1 PF077411 0.51 BTG PF077422 -0.19 HSCB_C PF077434 0.22 SPOC PF077441 -100.00 Glyco_hydro_53 PF077452 -100.00 LigA PF077461 -100.00 MTH865 PF077479 -1.69 Glyco_hydro_38C PF077485 -1.10 ERp29 PF077490 100.00 GcrA PF077500 100.00 Abi_2 PF07751

10 -0.41 DUF1610 PF077540 100.00 DUF1611 PF077554 -0.19 AdoMet_MTase PF077570 100.00 DUF1616 PF077600 100.00 DUF1618 PF077623 -1.29 FEZ PF077634 -100.00 KIP1 PF077654 -0.88 LETM1 PF077666 -0.59 Nop53 PF077670 100.00 PVL_ORF50 PF07768

Sheet1

0 100.00 PsiF_repeat PF077690 100.00 TSGP1 PF077711 -0.19 DUF1619 PF077731 -0.19 DUF1620 PF077740 100.00 PaRep2b PF07775

95 -1.61 zf-AD PF077761 0.51 MFMR PF077770 100.00 Mis6 PF077781 -0.19 Cas1p PF077792 -0.88 Spb1_C PF077800 100.00 Reovirus_Mu2 PF077813 -1.29 DC_STAMP PF077820 100.00 DUF1622 PF077842 -0.19 DUF1624 PF077861 1.42 DUF1625 PF077870 100.00 DUF1626 PF077882 -100.00 DUF1627 PF077893 -100.00 DUF1628 PF077902 0.22 DUF1630 PF077921 -100.00 DUF1631 PF077933 -1.29 DUF1635 PF077950 100.00 DUF1639 PF077972 -0.19 DUF1640 PF077980 100.00 DUF1643 PF077993 -0.19 DUF1644 PF078002 0.51 DUF1647 PF078011 -0.19 GCK PF078020 100.00 GSG-1 PF078030 100.00 HipA_C PF078040 100.00 HipA_N PF078051 0.91 RED_C PF078073 -0.19 RED_N PF078082 -0.88 RTP801_C PF078091 0.91 TMC PF078104 -100.00 TadE PF078112 -100.00 TfuA PF078128 -0.32 LTXXQ PF078132 -0.19 WAPL PF078141 -0.19 Abi_HHR PF078150 100.00 DUF1645 PF078161 0.51 GLE1 PF078171 -0.19 HCNGP PF07818

25 -0.57 PGAP1 PF078190 100.00 TraC PF078201 -100.00 Alpha-amyl_C2 PF078210 100.00 Toxin_13 PF078220 100.00 CPDase PF078230 100.00 Chaperone_III PF078243 -100.00 KNTase_C PF078273 -1.29 PP2C_C PF078302 -0.19 PYNP_C PF078311 -100.00 Cu_amine_oxidN1 PF078331 -0.19 RanGAP1_C PF078340 100.00 FTCD_N PF078371 -100.00 CaM_binding PF078390 100.00 FadR_C PF07840

25 -0.63 DM4_12 PF07841

Sheet1

3 -0.59 GCFC PF078421 -0.19 DUF1634 PF078431 -100.00 DUF1636 PF078450 100.00 Metallothio_7 PF078462 0.22 DUF1637 PF078470 100.00 PaaX PF078482 -0.88 DUF1641 PF078494 -1.57 Renin_r PF078508 0.87 TMPIT PF078510 100.00 DUF1642 PF078521 -100.00 DUF1648 PF078531 0.51 DUF1649 PF078552 -0.19 Orai-1 PF078560 100.00 DUF1632 PF078570 100.00 LEH PF07858

52 -0.61 Abhydrolase_3 PF078592 0.22 CCD PF078601 -0.19 Nif11 PF078620 100.00 DUF1651 PF078640 100.00 DUF1653 PF078661 -100.00 DUF1654 PF078671 -100.00 DUF1656 PF078691 -100.00 DUF1657 PF078700 100.00 DUF1658 PF078710 100.00 DUF1659 PF078720 100.00 YabP PF078731 0.91 DUF1660 PF078740 100.00 Coat_F PF078752 -0.88 DUF1661 PF078770 100.00 DUF1662 PF078781 0.91 PHB_acc_N PF078790 100.00 Fucose_iso_N1 PF078810 100.00 Fucose_iso_N2 PF078826 0.22 Cupin_2 PF078835 -1.80 VKOR PF07884

35 -0.31 Ion_trans_2 PF078851 -100.00 Calmodulin_bind PF078876 0.51 CALCOCO1 PF07888

47 -0.32 DUF1664 PF078892 -0.88 Rrp15p PF078900 100.00 DUF1666 PF078911 -100.00 DUF1667 PF078921 -100.00 DUF1668 PF078931 -0.19 DUF1669 PF078943 -0.59 DUF1673 PF078951 -0.19 DUF1674 PF078966 0.10 DUF1675 PF07897

21 -0.59 DUF1676 PF078980 100.00 Frigida PF078990 100.00 DUF1670 PF079000 100.00 DUF1672 PF079010 100.00 Gp58 PF079021 0.51 CT20 PF079041 -100.00 PucR PF079050 100.00 Toxin_15 PF079062 -100.00 YibE_F PF079071 -100.00 D-aminoacyl_C PF07908

Sheet1

2 0.22 Peptidase_C78 PF079102 -0.88 DUF1677 PF079113 -1.29 ERp29_N PF079121 0.91 DUF1678 PF07913

53 -1.22 DUF1679 PF079142 -0.19 PRKCSH PF079151 0.51 TraG_N PF079161 -100.00 DUF1683 PF079190 100.00 Fibritin_C PF079210 100.00 Glyco_transf_52 PF079222 -0.88 N1221 PF079230 100.00 NuiA PF07924

27 -0.44 TPR_MLP1_2 PF079260 100.00 YcfA PF079272 -0.88 Vps54 PF079281 -100.00 DAP_B PF079306 -0.59 CPT PF079312 -0.88 DUF1681 PF079331 0.51 OGG_N PF079340 100.00 SSV1_ORF_D-335 PF079350 100.00 Fungal_lectin PF079380 100.00 DUF1685 PF079390 100.00 Hepar_II_III PF079406 -0.37 K_channel_TID PF079411 -100.00 N2227 PF079420 100.00 PBP5_C PF079431 -0.19 DUF1680 PF079440 100.00 Toxin_16 PF079454 -0.47 DUF1682 PF079462 -0.88 YhhN PF079471 -0.19 Nairovirus_M PF079481 -0.19 YbbR PF079490 100.00 DUF1691 PF079500 100.00 Toxin_R_bind_C PF079510 100.00 Toxin_trans PF079522 -100.00 DUF1689 PF079542 -100.00 DUF1690 PF079560 100.00 DUF3294 PF079570 100.00 DUF1688 PF079581 -0.19 Fucokinase PF079591 -100.00 CBP4 PF079601 -100.00 MBA1 PF079611 0.91 Swi3 PF079621 -100.00 Red1 PF079641 0.51 Integrin_B_tail PF079652 -0.19 A1_Propeptide PF079661 1.20 zf-C3HC PF079673 -0.19 Amidohydro_3 PF079692 0.22 COPIIcoated_ERV PF079700 100.00 Glyco_hydro_92 PF079710 100.00 Flavodoxin_NdrI PF079726 -1.29 tRNA_SAD PF07973

36 -0.08 EGF_2 PF0797423 -0.06 C1_4 PF079751 -100.00 FabA PF079771 -0.19 NIPSNAP PF079780 100.00 SusD PF07980

Sheet1

0 100.00 Herpes_UL74 PF079821 -0.19 DUF1693 PF079842 -0.88 SRR1 PF079852 -0.19 TBCC PF079864 -1.57 Wos2 PF079884 -0.19 Microtub_assoc PF079899 -0.77 IlvN PF07991

54 -0.19 Pyr_redox_2 PF0799226 0.38 NAD_binding_4 PF079931 0.91 NAD_binding_5 PF079942 -100.00 T4SS PF079962 -0.19 DUF1694 PF079971 0.91 Peptidase_M54 PF079980 100.00 RHSP PF079990 100.00 CMV_US PF080011 -100.00 DUF1697 PF08002

10 -0.41 Methyltransf_9 PF080032 -0.88 DUF1699 PF080043 -0.19 PHR PF080052 0.51 DUF1700 PF080064 -0.47 Cupin_4 PF080070 100.00 Viral_cys_rich PF080081 -100.00 CDP-OH_P_tran_2 PF080090 100.00 Phage_30_3 PF080102 -0.88 Pheromone PF08015

19 - PKD_channel PF080160 100.00 Fibrinogen_BP PF080171 -0.19 Antimicrobial_1 PF080180 100.00 DUF1705 PF080191 -0.19 DUF1706 PF080202 -0.88 FAD_binding_9 PF080212 0.22 FAD_binding_8 PF080220 100.00 Antimicrobial_4 PF080240 100.00 Antimicrobial_3 PF080250 100.00 Antimicrobial_5 PF080267 -0.05 Acyl-CoA_dh_2 PF080280 100.00 HisG_C PF080295 - NAD_binding_6 PF080302 -0.19 SpoU_sub_bind PF080323 -0.59 Sec23_BS PF080330 100.00 TES PF080340 100.00 Op_neuropeptide PF080351 -0.19 Attractin PF080371 -100.00 Tom7 PF080381 -100.00 Mit_proteolip PF080391 -100.00 NADH_oxidored PF080402 -0.88 PetM PF080410 100.00 Xin PF080432 -100.00 DUF1707 PF080440 100.00 CDC14 PF080450 100.00 IlvGEDA_leader PF080462 -100.00 RepA1_leader PF080481 -100.00 Tet_res_leader PF080500 100.00 Ery_res_leader1 PF080510 100.00 PyrBI_leader PF080520 100.00 Tna_leader PF080530 100.00 Trp_leader1 PF08055

Sheet1

0 100.00 NPCC PF080582 -0.19 SEP PF080593 -0.59 NOSIC PF080600 100.00 P68HR PF080610 100.00 P120R PF080621 0.51 PADR1 PF080636 -0.88 UME PF080640 100.00 K167R PF080651 0.51 PMC2NT PF080662 -0.88 DKCLD PF080681 0.51 Ribosomal_S13_N PF080690 100.00 DTHCT PF080701 0.51 RS4NT PF080710 100.00 BDHCT PF080721 -0.19 CHDNT PF080731 -0.19 CHDCT2 PF080742 -0.88 NOPS PF080751 -100.00 PsaX PF080782 -0.88 Ribosomal_L30_N PF080791 -100.00 zf-RNPHF PF080801 -0.19 PRO8NT PF080821 -0.19 PROCN PF080832 -0.88 PROCT PF080841 0.51 Entericidin PF080850 100.00 Toxin_18 PF080870 100.00 Toxin_19 PF080880 100.00 Toxin_22 PF080920 100.00 Toxin_23 PF080931 0.51 Toxin_27 PF080990 100.00 Antimicrobial_8 PF081032 -0.88 Antimicrobial10 PF081051 -100.00 Antimicrobial11 PF081060 100.00 Antimicrobial12 PF081070 100.00 Pea-VEAacid PF081110 100.00 ATP-synt_E_2 PF081121 -100.00 CoxIIa PF081130 100.00 PMP1_2 PF081140 100.00 Toxin_28 PF081150 100.00 Toxin_29 PF081160 100.00 Toxin_30 PF081170 100.00 Toxin_31 PF081190 100.00 Toxin_32 PF081203 -100.00 NDUF_B12 PF081227 -0.34 DOT1 PF081230 100.00 Lyase_8_N PF081242 -0.88 Mannitol_dh_C PF081250 100.00 Propeptide_C25 PF081261 -100.00 Propeptide_C1 PF081270 100.00 Nuclease_act PF081330 100.00 cIII PF081340 100.00 EPV_E5 PF081351 -100.00 Ribosomal_S22 PF081364 -1.57 Sex_peptide PF081380 100.00 LPAM_1 PF081391 -100.00 Cuticle_1 PF081402 -0.19 AARP2CN PF081421 -100.00 CBFNT PF08143

Sheet1

1 0.51 CPL PF081441 -0.19 BOP1NT PF081453 -0.59 BP28CT PF081461 -0.19 DBP10CT PF081473 -0.59 DSHCT PF081484 -0.47 BING4CT PF081490 100.00 FerB PF081501 0.51 FerI PF081511 0.51 NGP1NT PF081532 -0.19 NLE PF081541 0.91 NOGCT PF081552 0.22 NOP5NT PF081560 100.00 NUC129 PF081574 -0.88 NUC130_3NT PF081582 0.22 NUC153 PF081591 0.51 NUC173 PF081610 100.00 NUC194 PF081632 -0.88 TRAUB PF081640 100.00 FerA PF081650 100.00 NUC202 PF081661 -100.00 NUC201 PF081672 -100.00 NUC205 PF081682 -0.88 RBB1NT PF081692 -0.88 POPLD PF081703 0.51 CASP_C PF081721 -100.00 DUF1709 PF081740 100.00 SspO PF081751 -0.19 GnsAB PF081780 100.00 SspP PF081791 -100.00 BAGE PF081800 100.00 DegQ PF081811 0.51 Pedibin PF081821 -100.00 SpoV PF081830 100.00 Cuticle_2 PF081840 100.00 Protamine_3 PF081880 100.00 Meleagrin PF081895 -0.70 PIH1 PF081908 -0.88 Peptidase_S64 PF081920 100.00 INO80_Ies4 PF08193

19 -3.13 DIM PF081941 -100.00 TRI9 PF081953 -1.29 UL2 PF081960 100.00 Thymopoietin PF081982 -100.00 E2 PF081992 0.22 Mis12_component PF08202

27 -0.08 V-set_CD47 PF0820477 0.03 C2-set_2 PF082057 -1.03 OB_RNB PF082061 -0.19 EFP_N PF082070 100.00 RNA_polI_A34 PF082085 0.51 Sgf11 PF082092 -100.00 APOBEC_N PF082103 -1.29 dCMP_cyt_deam_2 PF082115 -1.10 Lipocalin_2 PF082121 -0.19 DUF1713 PF082131 -0.19 KAT11 PF082143 -0.59 DUF1716 PF08216

Sheet1

1 -100.00 DUF1712 PF082170 100.00 Citrate_ly_lig PF082181 -100.00 HTH_DeoR PF082201 -100.00 HTH_9 PF082210 100.00 HTH_CodY PF082221 -100.00 DUF1719 PF082241 0.51 Antimicrobial19 PF082253 -0.19 DASH_Hsk3 PF082271 -0.19 RNase_P_pop3 PF082282 -0.88 SHR3_chaperone PF082291 -100.00 Cpl-7 PF082301 -0.19 SYF2 PF082317 -0.34 Striatin PF082324 -1.57 LNS2 PF082352 -0.88 SRI PF082361 1.42 PE-PPE PF082374 0.37 Sel1 PF082386 0.22 SH3_3 PF082397 0.17 ADH_N PF08240

41 -0.19 Methyltransf_11 PF0824137 -0.21 Methyltransf_12 PF082421 -0.19 SPT2 PF082432 -100.00 Glyco_hydro_32C PF082442 -0.88 Mur_ligase_M PF08245

11 -0.79 Inhibitor_I29 PF082460 100.00 ENOD40 PF082470 100.00 Mastoparan_2 PF082510 100.00 Leader_CPA1 PF082520 100.00 Leader_Erm PF082530 100.00 Antimicrobial20 PF082562 -0.19 Sulfakinin PF082571 -100.00 Periviscerokin PF082591 -100.00 Carcinustatin PF082610 100.00 Lem_TRP PF082621 -100.00 LRRNT_2 PF082638 -0.32 Anticodon_1 PF082643 -0.19 YL1_C PF08265

11 0.31 Cadherin_2 PF082662 0.22 Cache_2 PF082690 100.00 PRD_Mga PF08270

18 0.22 TF_Zn_Ribbon PF082710 100.00 Topo_Zn_Ribbon PF082726 -0.37 Prim_Zn_Ribbon PF08273

13 -0.81 PhnA_Zn_Ribbon PF082741 -0.19 Toprim_N PF082754 -1.57 PAN_2 PF082763 -0.19 PAN_3 PF082771 0.51 DnaG_DnaB_bind PF082783 0.66 HTH_11 PF082791 0.51 HTH_Mga PF082804 -0.88 Sigma70_r4_2 PF08281

16 -0.39 Hydrolase_3 PF082821 -100.00 Gemini_AL1_M PF082831 0.91 RVP_2 PF082844 -0.19 DPM3 PF082856 -1.29 Spc24 PF082860 100.00 DASH_Spc19 PF08287

Sheet1

1 0.91 PIGA PF082880 100.00 Flu_M1_C PF082890 100.00 Hep_core_N PF082900 100.00 Peptidase_M15_3 PF082912 0.91 RNA_pol_Rbc25 PF082921 0.51 MRP-S33 PF082932 -0.19 TIM21 PF082941 0.51 HDAC_interact PF082950 100.00 U3_snoRNA_assoc PF082973 -1.29 AAA_PrkA PF082980 100.00 tRNA_lig_CPD PF083021 -100.00 tRNA_lig_kinase PF083030 100.00 Glyco_hydro_98M PF083063 -1.29 PEGA PF083085 -100.00 LVIVD PF083091 -100.00 LGFP PF083106 -0.88 Mad3_BUB1_I PF083111 -0.19 cwf21 PF083120 100.00 SCA7 PF083130 100.00 Sec39 PF083141 -0.19 cwf18 PF083150 100.00 Pal1 PF08316

28 -0.15 Spc7 PF083172 -0.19 COG4 PF083180 100.00 PIG-X PF083201 -0.19 PPP5 PF083214 -1.57 Glyco_transf_5 PF083232 -0.88 PUL PF083241 -0.19 WLM PF083251 -0.19 ACC_central PF083261 -0.19 AHSA1 PF083274 -0.88 ASL_C PF083282 -0.88 DUF1730 PF083311 -0.19 CaMKII_AD PF083320 100.00 DUF1725 PF083332 -0.88 GSPII_G PF083341 -100.00 GlnD_UR_UTase PF08335

27 -1.87 P4Ha_N PF083367 -1.44 Plexin_cytopl PF083371 0.51 DUF1731 PF083381 -100.00 RTX_C PF083392 -100.00 DUF1732 PF083400 100.00 Fb_signal PF083410 100.00 RNR_N PF083434 -0.47 TRP_2 PF083440 100.00 YscJ_FliF_C PF083450 100.00 AntA PF083461 -0.19 CTNNB1_binding PF083470 100.00 PAS_6 PF083480 100.00 DUF1722 PF083490 100.00 DUF1724 PF083501 -0.19 DUF1726 PF083510 100.00 oligo_HPY PF083521 -100.00 DUF1729 PF083541 0.51 EF_assoc_1 PF083551 -0.19 EF_assoc_2 PF083560 100.00 SEFIR PF08357

Sheet1

0 100.00 Flexi_CP_N PF083581 -0.19 TetR_C_4 PF083590 100.00 TetR_C_5 PF083600 100.00 TetR_C_2 PF083612 -0.19 LLGL PF083662 -0.19 M16C_assoc PF083672 0.22 FAST_2 PF083681 -0.19 PCP_red PF083691 -0.19 PDR_assoc PF083702 -0.88 PLD_envelope PF083711 0.91 PRT_C PF083723 -1.29 RAP PF083738 -0.07 Protocadherin PF083742 -0.88 Rpn3_C PF083752 -0.88 NIT PF083760 100.00 MAP2_projctn PF083770 100.00 NERD PF083780 100.00 NPP PF083847 0.35 DHC_N1 PF083851 -0.19 Abhydrolase_4 PF083860 100.00 FBD PF083871 -100.00 GIIM PF08388

13 -0.11 Xpo1 PF083891 -0.19 TRAM1 PF083905 - Ly49 PF083911 -100.00 FAE1_CUT1_RppA PF08392

10 0.15 DHC_N2 PF083934 -0.47 Arc_trans_TRASH PF08394

81 -0.67 7tm_7 PF083950 100.00 Toxin_34 PF083966 -0.37 IMD PF083970 100.00 Parvo_coat_N PF083983 -0.19 VWA_N PF083991 -100.00 phage_tail_N PF084000 100.00 TOBE_2 PF084021 0.51 AA_permease_N PF084031 -100.00 CbbQ_C PF084060 100.00 Chitin_synth_1N PF084070 100.00 DNA_pol_B_3 PF084084 0.04 DUF1736 PF084090 100.00 Exonuc_X-T_C PF084116 0.10 Ion_trans_N PF084120 100.00 Metallophos_C PF084130 100.00 NADPH_Ox PF084148 -0.19 PTB PF084162 -100.00 PaO PF084177 -1.44 Pol_alpha_B_N PF084181 -0.19 zf-C4_C PF084200 100.00 Methyltransf_13 PF084215 -0.70 Rad51 PF084232 0.91 DUF1740 PF084240 100.00 ICE2 PF084262 -0.88 DUF1741 PF084271 -0.19 Rib PF084281 0.51 PLU-1 PF084293 -0.59 Fork_head_N PF084307 -0.34 DUF1742 PF08432

Sheet1

18 -1.29 KTI12 PF084332 -0.88 Calici_coat_C PF084350 100.00 Glyco_transf_8N PF084370 100.00 MMR_HSR1_C PF084383 -1.29 Peptidase_M3_N PF084390 100.00 Poty_PP PF084405 -0.70 Integrin_alpha2 PF084414 -0.47 ATP-grasp_2 PF084426 -0.03 RimK PF084433 -100.00 Gly_acyl_tr_C PF08444

24 -0.97 FR47 PF084452 -0.88 PAS_2 PF08446

13 -0.19 PAS_3 PF0844710 -0.70 PAS_4 PF0844810 -0.09 UAA PF0844920 -0.48 SGL PF084506 -1.29 A_deaminase_N PF084510 100.00 DNAP_B_exo_N PF084521 -0.19 Peptidase_M9_N PF084532 -0.19 RIH_assoc PF084540 100.00 SNF2_assoc PF084552 -100.00 Vmethyltransf_C PF084561 -100.00 Sfi1 PF084570 100.00 PH_2 PF084580 100.00 UvrC_HhH_N PF084590 100.00 SH3_5 PF084602 -0.88 HTH_12 PF084610 100.00 EcoEI_R_C PF084630 100.00 Gemini_AC4_5_2 PF084640 100.00 Herpes_TK_C PF084650 100.00 Luteo_P1-P2 PF084671 -0.19 MTS_N PF084680 100.00 NPHI_C PF084691 -0.19 NTNH_C PF084700 100.00 S6PP_C PF084721 0.51 VGCC_alpha2 PF084730 100.00 MYT1 PF084741 -100.00 Baculo_VP91_N PF084751 -0.19 VD10_N PF08476

164 -0.49 Miro PF084770 100.00 POTRA_1 PF084781 0.51 POTRA_2 PF084790 100.00 Disaggr_assoc PF084800 100.00 HrpB_C PF084820 100.00 IstB_N PF084831 0.51 Methyltransf_14 PF084840 100.00 Polysacc_syn_2C PF084850 100.00 VIT PF084870 100.00 DUF1743 PF084892 -0.88 DUF1744 PF084902 -0.19 SE PF084911 0.51 SRP72 PF084923 -1.29 AflR PF084930 100.00 DEAD_assoc PF084949 -0.44 Peptidase_S49_N PF084962 -0.88 Radical_SAM_N PF084971 -0.19 PDEase_I_N PF08499

Sheet1

0 100.00 LeuA_dimer PF085020 100.00 DapD_N PF085031 -100.00 DSL1 PF085053 -0.19 Cse1 PF085060 100.00 COPI_assoc PF085070 100.00 DUF1746 PF085081 0.51 Ad_cyc_g-alpha PF085093 -0.19 PIG-P PF085101 -100.00 COQ9 PF08511

19 -0.30 Rtt106 PF085129 -0.77 LisH PF085132 0.22 STAG PF085143 -0.19 TGF_beta_GS PF085152 -0.88 ADAM_CR PF085162 -100.00 AXH PF085172 -0.19 GIT_SHD PF085183 -1.29 RFC1 PF085190 100.00 DUF1735 PF085221 -0.19 MBF1 PF085231 -0.19 rRNA_processing PF085241 -0.19 OapA_N PF085250 100.00 PAD_M PF085270 100.00 Whi5 PF085281 -100.00 NusA_N PF085291 -100.00 PepX_C PF085300 100.00 Bac_rhamnosid_N PF085310 100.00 Glyco_hydro_42M PF085320 100.00 Glyco_hydro_42C PF08533

24 -0.88 Redoxin PF085340 100.00 KorB PF085352 -100.00 Whirly PF085360 100.00 NBP1 PF085370 100.00 DUF1749 PF085381 -0.19 HbrB PF085391 -0.19 HMG_CoA_synt_C PF085402 -0.88 ACP_syn_III_C PF085416 -0.37 Rep_fac_C PF085422 -0.19 Phos_pyr_kin PF085435 0.15 GHMP_kinases_C PF085446 0.42 ACP_syn_III PF085451 -100.00 ApbA_C PF085461 0.51 CIA30 PF085470 100.00 Peptidase_M10_C PF085480 100.00 SWI-SNF_Ssr4 PF085490 100.00 DUF1752 PF085501 0.91 DUF1751 PF085513 -0.59 Kei1 PF085529 -1.29 VID27 PF085531 1.20 DUF1754 PF085551 0.91 Lipid_DES PF085570 100.00 TRF PF085581 0.51 Cut8 PF085591 -0.19 Ribosomal_L37 PF085610 100.00 Crisp PF085622 -100.00 P53_TAD PF085631 -0.19 CDC37_C PF085641 -100.00 CDC37_M PF08565

Sheet1

0 100.00 Pam17 PF085661 0.51 TFIIH_BTF_p62_N PF085671 -100.00 Kinetochor_Ybp2 PF085685 -0.70 Mo25 PF085691 -0.19 Yos1 PF085711 -0.19 PRP3 PF085723 -0.19 SAE2 PF085731 -100.00 DUF1762 PF085741 -100.00 DUF1763 PF085759 -1.69 DUF1764 PF085760 100.00 PI31_Prot_Reg PF085770 100.00 DUF1765 PF085780 100.00 RPM2 PF085790 100.00 KAR9 PF085804 0.51 Tup_N PF085819 -1.00 Cmc1 PF085830 100.00 Ribonuc_P_40 PF085841 0.51 DUF1767 PF085851 -0.19 Rsc14 PF085862 -100.00 UBA_2 PF085871 -100.00 DUF1769 PF085883 -100.00 DUF1771 PF085900 100.00 RNR_inhib PF085913 -0.19 DUF1772 PF085921 -100.00 MUG2_C PF085936 0.42 RXT2_N PF085952 -0.19 Lgl_C PF085964 -1.57 eIF3_subunit PF085973 0.10 Sds3 PF085981 -100.00 Nbs1_C PF085993 -0.59 Rsm1 PF086006 -1.98 PAP1 PF086010 100.00 Mgr1 PF086022 0.22 CAP_C PF086030 100.00 Nup153 PF086040 100.00 Rad9_Rad53_bind PF086051 1.20 Prp19 PF086061 -0.19 Fes1 PF086096 -0.59 Pex16 PF086100 100.00 DUF1774 PF086111 0.51 Med20 PF086121 -0.19 Cyclin PF08613

25 0.21 ATG16 PF086142 -0.19 RNase_H2_suC PF086153 0.51 SPB_interacting PF086160 100.00 CGI-121 PF086170 100.00 Opi1 PF086182 -0.88 Nha1_C PF086191 -0.19 RPAP1_C PF086202 -0.88 RPAP1_N PF086210 100.00 Svf1 PF086226 -0.59 TIP120 PF086230 100.00 CRC_subunit PF086243 -0.59 Utp13 PF086250 100.00 Trs120 PF086261 -100.00 CRT-like PF086272 -0.19 Nexin_C PF08628

Sheet1

1 -100.00 PDE8 PF086290 100.00 Dfp1_Him1_M PF086303 -1.29 SPO22 PF086310 100.00 Pet127 PF086341 0.91 Med14 PF086380 100.00 SLD3 PF086392 0.22 U3_assoc_6 PF086400 100.00 Mis14 PF086410 100.00 Rxt3 PF08642

12 -0.88 DUF1776 PF086433 -0.59 SPT16 PF086442 -0.19 PNK3P PF086454 0.22 Rep_fac-A_C PF086461 0.91 BRE1 PF08647

14 0.06 DUF1777 PF086481 -0.19 DASH_Dad1 PF086492 -100.00 DASH_Dad4 PF086503 -100.00 DASH_Duo1 PF086512 -0.88 RAI1 PF086526 -0.37 DASH_Dam1 PF086531 -100.00 DASH_Dad2 PF086540 100.00 DASH_Ask1 PF086553 -0.19 DASH_Dad3 PF086560 100.00 DASH_Spc34 PF086571 0.51 Rad54_N PF08658

65 -0.08 KR PF086592 -100.00 Alg14 PF086602 -0.88 Rep_fac-A_3 PF08661

51 -0.48 eIF2A PF086621 -0.19 HalX PF086630 100.00 YcbB PF086641 0.51 PglZ PF086652 -0.88 SAF PF086660 100.00 BetR PF086674 0.04 GCV_T_C PF086691 -100.00 MEKHLA PF086701 -0.19 SinI PF086712 -0.88 APC2 PF086721 0.91 RsbU_N PF086730 100.00 AChE_tetra PF08674

10 -0.19 RNA_bind PF086751 0.91 MutL_C PF086763 -100.00 Rsbr_N PF086781 0.51 DsrD PF086791 -100.00 DUF1779 PF086801 -0.19 DUF1778 PF086811 0.51 CAMSAP_CKK PF086830 100.00 ocr PF086841 -100.00 GON PF086853 -0.19 PLAC PF086862 -0.88 ASD2 PF086870 100.00 ASD1 PF086885 -1.80 GET2 PF086900 100.00 Nse5 PF08691

10 -0.09 SKG6 PF086931 -100.00 UFC1 PF086942 -0.88 DUF1783 PF08695

Sheet1

3 -1.29 Dna2 PF086961 -0.19 Fcf2 PF086982 -0.19 DUF1785 PF08699

10 -0.29 Vps51 PF087001 -0.19 GN3L_Grn1 PF08701

25 -0.32 Fib_alpha PF087021 -0.19 PLC-beta_C PF087033 0.10 GCD14 PF087043 -1.29 D5_N PF087060 100.00 PriCT_2 PF087073 -0.59 Ins145_P3_rec PF087093 0.51 Med26 PF087113 -0.59 Nfu_N PF087125 -1.10 DNA_alkylation PF087130 100.00 Fae PF087140 100.00 Viral_protease PF087151 0.51 nsp7 PF087160 100.00 nsp8 PF087172 -0.19 GLTP PF087180 100.00 DUF1768 PF087190 100.00 Hema_stalk PF087200 100.00 TnsA_C PF087210 100.00 TnsA_N PF087222 0.22 Integrin_b_cyt PF08725

16 -1.35 efhand_Ca_insen PF087262 -0.88 P3A PF087274 -0.88 CRT10 PF08728

13 -0.67 HPC2 PF087290 100.00 Rad33 PF087300 100.00 AFT PF087310 100.00 PalH PF087330 100.00 GYD PF087340 100.00 DUF1786 PF087354 -0.19 FA PF087366 -1.29 Rgp1 PF087370 100.00 Gon7 PF087383 -1.29 BCS1_N PF087400 100.00 YwhD PF087413 -1.29 C8 PF087422 -0.88 Nse4 PF087430 100.00 UPF0278 PF08745

15 -0.33 zf-RING-like PF087460 100.00 DUF1788 PF087470 100.00 DUF1789 PF087480 100.00 DUF1790 PF087491 -0.19 Gamma-COP PF087521 -100.00 NikR_C PF087531 0.51 YccV-like PF087551 -100.00 CotH PF087576 -1.29 Cadherin_pro PF087580 100.00 DUF1792 PF087591 -0.19 DUF1793 PF087600 100.00 dUTPase_2 PF087611 -100.00 CRPV_capsid PF087625 -0.70 Ca_chan_IQ PF087630 100.00 Coagulase PF087640 100.00 Mor PF08765

Sheet1

4 -0.88 DEK_C PF087663 -1.29 CRM1_C PF087671 -0.19 DUF1794 PF087680 100.00 Spo0A_C PF087690 100.00 SoxZ PF087702 0.73 Rapamycin_bind PF087712 -0.88 NOB1_Zn_bind PF087721 -100.00 CathepsinC_exc PF087730 100.00 VRR_NUC PF087741 -0.19 ParB PF087751 0.91 VASP_tetra PF08776

23 -0.33 RRM_3 PF087770 100.00 SARS_X4 PF087790 100.00 NTase_sub_bind PF087802 -0.88 DP PF087814 -0.19 c-SKI_SMAD_bind PF087822 -0.88 DWNN PF087831 0.51 RPA_C PF087844 -100.00 Ku_PK_bind PF087850 100.00 DUF1795 PF087861 -100.00 Alginate_lyase2 PF087872 -0.88 NHR2 PF08788

13 -0.27 zf-LYAR PF087908 -0.19 A2L_zn_ribbon PF087921 0.51 2C_adapt PF087930 100.00 Lipoprot_C PF087940 100.00 DUF1796 PF087952 -100.00 DUF1797 PF087960 100.00 HIRAN PF087972 0.73 PRP4 PF08799

20 -0.41 Nucleoporin_N PF088010 100.00 CytB6-F_Fe-S PF088020 100.00 ydhR PF088031 -0.19 gp32 PF088042 -0.88 Sep15_SelM PF088061 -100.00 DUF1798 PF088071 -0.19 KapB PF088100 100.00 DUF1800 PF088110 100.00 YtxC PF088121 -0.19 Nuc_rec_co-act PF088150 100.00 DUF1801 PF088180 100.00 DUF1803 PF088201 -100.00 CGGC PF088211 -100.00 DUF1804 PF088221 -0.19 PG_binding_2 PF088232 -0.88 Serine_rich PF088242 0.73 E2_bind PF088253 -0.19 DMPK_coil PF088262 -0.19 DUF1805 PF088272 -0.88 DSX_dimer PF088280 100.00 AlphaC_N PF088291 -0.19 MHCassoc_trimer PF088310 100.00 SRC-1 PF088321 -100.00 Axin_b-cat_bind PF088332 -100.00 DUF1810 PF088372 -0.88 DUF1811 PF088381 -0.19 CDT1 PF08839

Sheet1

4 0.37 BAAT_C PF088403 -0.59 DDR PF088410 100.00 DUF1814 PF088431 -0.19 DUF1815 PF088440 100.00 DUF1816 PF088460 100.00 DUF1817 PF088470 100.00 DUF1818 PF088482 -0.88 DUF1819 PF088490 100.00 DUF1820 PF088500 100.00 DUF1822 PF088520 100.00 DUF1823 PF088531 -100.00 DUF1824 PF088541 0.51 DUF1825 PF088550 100.00 DUF1826 PF088561 -100.00 ParBc_2 PF088571 0.51 IDEAL PF088580 100.00 DUF1827 PF088600 100.00 DUF1828 PF088610 100.00 DUF1829 PF088620 100.00 YolD PF088630 100.00 UPF0302 PF088643 -100.00 DUF1830 PF088651 -100.00 DUF1831 PF088660 100.00 YugN PF088681 -100.00 XisI PF088690 100.00 DUF1832 PF088700 100.00 KGK PF088720 100.00 DUF1835 PF088740 100.00 DUF1833 PF088750 100.00 DUF1836 PF088760 100.00 MepB PF088770 100.00 DUF1837 PF088780 100.00 WRC PF088793 -0.19 QLQ PF088800 100.00 CVNH PF088812 -100.00 Acetone_carb_G PF088820 100.00 DOPA_dioxygen PF088830 100.00 Flagellin_D3 PF088841 -100.00 GSCFA PF088851 -100.00 GAD-like PF088870 100.00 HopJ PF088880 100.00 WbqC PF088890 100.00 XkdN PF088901 -0.19 YfcL PF088910 100.00 DUF1839 PF088931 0.51 DUF1840 PF088950 100.00 DUF1842 PF088968 -0.47 DUF1843 PF088980 100.00 DUF1844 PF088990 100.00 DUF1845 PF089000 100.00 DUF1847 PF089011 -100.00 DUF1846 PF089030 100.00 DUF1850 PF089050 100.00 DUF1851 PF089060 100.00 DUF1853 PF089070 100.00 DUF1852 PF089080 100.00 DUF1854 PF08909

Sheet1

0 100.00 DUF1855 PF089101 -0.19 NUP50 PF089111 0.51 Rho_Binding PF089121 0.51 VBS PF089133 -0.59 Myb_DNA-bind_2 PF089141 0.51 tRNA-Thr_ED PF089153 -100.00 Phe_ZIP PF089160 100.00 ecTbetaR2 PF089171 -100.00 PhoQ_Sensor PF089180 100.00 F_actin_bind PF089192 0.22 SF3b1 PF089200 100.00 DUF1904 PF089210 100.00 DUF1905 PF089222 -0.88 MAPKK1_Int PF089232 -0.88 DUF1907 PF089251 -0.19 DUF1908 PF089261 -0.19 DUF1910 PF089280 100.00 DUF1911 PF089290 100.00 DUF1914 PF089320 100.00 DUF1864 PF089330 100.00 Rb_C PF089340 100.00 DUF1865 PF089353 -1.29 DUF1863 PF089377 -0.75 DUF1916 PF089383 -100.00 DUF1917 PF089390 100.00 DUF1918 PF089402 -0.19 USP8_interact PF089410 100.00 DUF1919 PF089422 -100.00 CsiD PF089431 -0.19 p47_phox_C PF089443 0.10 Osmo_CC PF089460 100.00 BPS PF089470 100.00 DUF1860 PF089490 100.00 DUF1861 PF089500 100.00 EntA_Immun PF089512 -0.88 DUF1866 PF089522 0.22 DUF1899 PF089533 0.10 DUF1900 PF089540 100.00 DUF1871 PF089580 100.00 DUF1872 PF089590 100.00 DUF1875 PF089611 -100.00 DUF1878 PF089630 100.00 DUF1881 PF089640 100.00 DUF1870 PF089650 100.00 DUF1884 PF089670 100.00 DUF1885 PF089682 -0.88 DUF1873 PF089690 100.00 Sda PF089700 100.00 GlgS PF089710 100.00 DUF1902 PF089720 100.00 DUF1893 PF089731 -0.19 DUF1877 PF089742 -100.00 DUF1880 PF089761 -100.00 Reoviridae_Vp9 PF089780 100.00 DUF1883 PF089801 -100.00 DUF1857 PF089820 100.00 DUF1856 PF08983

Sheet1

0 100.00 DUF1858 PF089841 -100.00 DUF1888 PF089851 -100.00 DUF1892 PF089871 -100.00 Docking PF089903 -0.59 DUF1903 PF089911 -0.19 T4-helicase_N PF089931 -100.00 T4-helicase_C PF089940 100.00 NIP_1 PF089957 -0.34 zf-DNA_Pol PF089961 -100.00 UCR_6-4kD PF089970 100.00 Epsilon_antitox PF089981 0.51 SP_C-Propep PF089990 100.00 Cytotoxic PF090000 100.00 DUF1890 PF090011 -100.00 DUF1887 PF090021 -0.19 DUF1891 PF090041 0.51 DUF1897 PF090051 0.91 Surfac_D-trimer PF090060 100.00 EBP50_C-term PF090070 100.00 Head_binding PF090080 100.00 AsiA PF090100 100.00 DUF1898 PF090114 -1.57 FeoC PF090120 100.00 YopH_N PF090130 100.00 Sushi_2 PF090141 -100.00 NgoMIV_restric PF090150 100.00 Pas_Saposin PF090160 100.00 Transglut_prok PF090170 100.00 EcoRII-C PF090190 100.00 YopE_N PF09020

19 -0.65 Cenp-B_dimeris PF090260 100.00 GTPase_binding PF090270 100.00 Mac-1 PF090283 -1.29 Preseq_ALAS PF090290 100.00 Creb_binding PF090303 -0.59 Siah-Interact_N PF090321 -0.19 DFF-C PF090330 100.00 TRADD_N PF090341 -100.00 Tn916-Xis PF090352 -0.88 Bcr-Abl_Oligo PF090361 -0.19 Sulphotransf PF090370 100.00 53-BP1_Tudor PF090380 100.00 Mu_I-gamma PF090390 100.00 Aurora-A_bind PF090411 0.51 Titin_Z PF090421 -100.00 Lys-AminoMut_A PF090430 100.00 Kp4 PF090441 0.91 L27_2 PF090450 100.00 AvrPtoB-E3_ubiq PF090460 100.00 MEF2_binding PF090470 100.00 Cro PF090481 -0.19 SNN_transmemb PF090491 -0.19 SNN_cytoplasm PF090510 100.00 Sod_Ni PF090550 100.00 Smac_DIABLO PF090572 0.22 L27_1 PF090581 -100.00 TyeA PF09059

Sheet1

1 -0.19 L27_N PF090600 100.00 Stirrup PF090611 -100.00 Endonuc_subdom PF090620 100.00 Tme5_EGF_like PF090643 -0.59 B2-adapt-app_C PF090660 100.00 EpoR_lig-bind PF090673 0.32 efhand_1 PF090682 0.22 efhand_2 PF090691 0.51 PFU PF090700 100.00 Alpha-amyl_C PF090711 -0.19 TMA7 PF09072

13 -0.35 BUD22 PF090731 -0.19 Mer2 PF090741 -100.00 STb_secrete PF090750 100.00 Sklp_toxin PF090760 100.00 CheY-binding PF090783 -0.59 Cdc6_C PF090790 100.00 K-cyclin_vir_C PF090802 -100.00 DUF1921 PF090811 -0.19 NMT1 PF090840 100.00 Adhes-Ig_like PF090853 -1.29 MIF4G_like PF090882 -0.19 MIF4G_like_2 PF090900 100.00 Lyase_N PF090920 100.00 Lyase_catalyt PF090931 -100.00 DUF1925 PF090941 -100.00 DUF1926 PF090950 100.00 Phage-tail_2 PF090960 100.00 DUF1927 PF090991 -100.00 DUF1928 PF091001 0.51 Exotox-A_target PF091021 -100.00 BRCA-2_OB1 PF091030 100.00 BRCA-2_OB3 PF091040 100.00 SelB-wing_3 PF091070 100.00 Xol-1_N PF091082 -0.88 HAND PF091102 0.22 SLIDE PF091111 -100.00 PngaseF_C PF091131 -0.19 MotA_activ PF091140 100.00 DNApol3-delta_C PF091150 100.00 MiAMP1 PF091170 100.00 Tower PF091211 -0.19 DUF1931 PF091230 100.00 COX2-transmemb PF091250 100.00 NaeI PF091262 -100.00 Leuk-A4-hydro_C PF091271 -0.19 RGS-like PF091281 0.51 DUF1932 PF091301 0.91 SANTA PF091332 -100.00 Alb1 PF091351 0.91 Urm1 PF091381 -0.19 Mmp37 PF091393 0.51 MipZ PF091401 0.91 Talin_middle PF091411 -100.00 TruB_C PF091420 100.00 YpM PF091440 100.00 BmKK2_toxic PF09146

Sheet1

1 -100.00 DUF1933 PF091470 100.00 DUF1935 PF091490 100.00 Carot_N PF091503 -1.29 DUF1936 PF091510 100.00 DUF1937 PF091520 100.00 DUF1938 PF091531 -100.00 DUF1940 PF091551 -100.00 Anthrax-tox_M PF091560 100.00 MotCF PF091581 -100.00 Ydc2-catalyt PF091590 100.00 FimH_man-bind PF091601 0.51 Tap-RNA_bind PF091621 -0.19 Form-deh_trans PF091630 100.00 VitD-bind_III PF091640 100.00 Ubiq-Cytc-red_N PF091650 100.00 Biliv-reduc_cat PF091661 -100.00 BRCA-2_helical PF091690 100.00 DUF1879 PF091700 100.00 DUF1886 PF091714 0.51 DUF1943 PF091721 -0.19 eIF2_C PF091730 100.00 Maf1 PF091741 0.51 DUF1944 PF09175

15 - Syntaxin-6_N PF091771 -100.00 DUF1945 PF091780 100.00 TilS PF091791 0.51 ProRS-C_1 PF091800 100.00 ProRS-C_2 PF091811 -100.00 PuR_N PF091821 -0.19 DUF1947 PF091835 -0.41 PPP4R2 PF091840 100.00 DUF1949 PF091860 100.00 DUF1950 PF091870 100.00 DUF1951 PF091881 -0.19 DALR_2 PF091900 100.00 Act-Frag_cataly PF091920 100.00 CholecysA-Rec_N PF091930 100.00 Endonuc-BsobI PF091940 100.00 Endonuc-BglII PF091950 100.00 DUF1953 PF091960 100.00 Rap1-DNA-bind PF091971 -100.00 T4-Gluco-transf PF091980 100.00 SRX PF092011 0.91 Rio2_N PF092020 100.00 MspA PF092030 100.00 ColicinD PF092040 100.00 DUF1955 PF092050 100.00 DUF1956 PF092090 100.00 DUF1957 PF092101 1.20 DUF1958 PF092111 0.51 Pfg27 PF092160 100.00 DUF1959 PF092180 100.00 LA-virus_coat PF092201 -100.00 Bacteriocin_IId PF092210 100.00 Endonuc-PvuII PF092250 100.00 DUF1962 PF092270 100.00 Prok-TraM PF09228

Sheet1

1 -0.19 Aha1_N PF092291 -0.19 DFF40 PF092300 100.00 RDV-p3 PF092310 100.00 Caenor_Her-1 PF092323 -0.19 Ste50p-SAM PF092351 -100.00 AHSP PF09236

38 0.03 GAGA PF092370 100.00 IL4Ra_N PF092380 100.00 Topo-VIb_trans PF092390 100.00 IL6Ra-bind PF092400 100.00 Herp-Cyclin PF092412 -0.88 Rsm22 PF092432 -100.00 DUF1964 PF092442 -0.88 MA-Mit PF092451 -0.19 PHAT PF092461 0.51 TBP-binding PF092471 -100.00 DUF1965 PF092482 0.22 tRNA_NucTransf2 PF092490 100.00 Feld-I_B PF092520 100.00 Endonuc-FokI_C PF092540 100.00 Antig_Caf1 PF092553 -0.59 BaffR-Tall_bind PF092560 100.00 BCMA-Tall_bind PF092573 -0.59 Glyco_transf_64 PF092588 -1.57 Alpha-mann_mid PF092611 -100.00 PEX-1N PF092620 100.00 PEX-2N PF092631 -100.00 Sial-lect-inser PF092640 100.00 VirDNA-topo-I_N PF092660 100.00 Dict-STAT-coil PF092671 0.51 Clathrin-link PF092681 -0.19 DUF1967 PF092692 -0.19 Beta-trefoil PF092701 -0.19 LAG1-DNAbind PF092713 -0.59 Hepsin-SRCR PF092721 -100.00 Rubis-subs-bind PF092730 100.00 ParG PF092741 -0.19 Erythro-docking PF092773 0.32 MerR-DNA-bind PF092785 -0.41 efhand_like PF092795 -1.10 XPC-binding PF092802 -0.88 Mago-bind PF092820 100.00 RhgB_N PF092840 100.00 Elong-fact-P_C PF092850 100.00 Pro-kuma_activ PF092860 100.00 CEP1-DNA_bind PF092872 -0.19 UBA_3 PF092881 0.51 FOLN PF092891 -100.00 AcetDehyd-dimer PF092901 -0.19 DUF1968 PF092910 100.00 Neil1-DNA_bind PF092920 100.00 RNaseH_C PF09293

11 -0.10 Interfer-bind PF092944 0.51 ChAPs PF092950 100.00 zf-NADH-PPase PF092974 -1.57 DUF1969 PF092980 100.00 Mu-transpos_C PF09299

Sheet1

2 -0.19 XLF PF093022 1.07 Cortex-I_coil PF093041 -0.19 TACI-CRD2 PF093051 -100.00 Phage-scaffold PF093062 -0.88 MHC2-interact PF093076 -1.98 FCP1_C PF093091 -0.19 PD-C2-AF1 PF093104 0.22 Rab5-bind PF093111 -100.00 SurA_N PF093121 -0.19 DUF1971 PF093131 -100.00 DUF1973 PF093151 -0.19 Cmyb_C PF093160 100.00 DUF1974 PF093170 100.00 DUF1975 PF093182 -0.88 DUF1977 PF093202 -100.00 DUF1978 PF093216 -0.88 DUF1980 PF09323

11 -0.51 DUF1981 PF093243 0.79 Vps5 PF093251 -0.19 DUF1982 PF093260 100.00 Phytochelatin_C PF093282 -0.88 zf-primase PF093290 100.00 Lact-deh-memb PF093300 100.00 DUF1985 PF093312 -0.88 Mcm10 PF093324 -0.47 ATG_C PF09333

11 -0.10 tRNA-synt_1g PF093344 -0.88 SNARE_assoc PF09335

10 -0.88 Vps4_C PF093360 100.00 zf-H2C2 PF093371 -100.00 Gly_reductase PF093382 0.73 HTH_IclR PF093391 1.20 NuA4 PF093400 100.00 Pcc1 PF09341

101 -1.34 DUF1986 PF093420 100.00 DUF2460 PF093434 -1.57 DUF1987 PF093450 100.00 SMI1_KNR4 PF093461 -100.00 DUF1989 PF093471 -100.00 DUF1990 PF093480 100.00 OHCU_decarbox PF093491 -100.00 DUF1992 PF093501 -100.00 DUF1993 PF093510 100.00 DUF1994 PF093521 0.51 HNF_C PF093540 100.00 Phage_Gp19 PF093550 100.00 Phage_BR0599 PF093560 100.00 RteC PF093571 -0.19 UBA_e1_C PF093580 100.00 VTC PF093592 -0.19 zf-CDGSH PF093601 -0.19 Phasin_2 PF093610 100.00 XFP_C PF093631 -100.00 XFP_N PF093640 100.00 DUF1997 PF093660 100.00 CpeS PF093671 -0.19 Sas10_Utp3_C PF09368

Sheet1

0 100.00 DUF1998 PF093692 -0.88 Tex_N PF093712 -0.88 PRANC PF093720 100.00 PMBR PF093732 -0.88 PG_binding_3 PF093740 100.00 Peptidase_M75 PF093750 100.00 NurA PF093762 -0.19 SBDS_C PF093772 -0.19 HAS-barrel PF09378

19 -0.24 FERM_N PF0937911 -0.10 FERM_C PF093801 0.91 RQC PF093821 0.91 UTP15_C PF093841 -0.19 HisK_N PF093851 -0.19 ParD PF093860 100.00 MRP PF093871 -100.00 SpoOE-like PF093880 100.00 DUF2000 PF093910 100.00 MxiH PF093920 100.00 Chagasin_I42 PF093941 -100.00 Thrombin_light PF093960 100.00 Ftsk_gamma PF093972 0.51 FOP_dimer PF093980 100.00 SARS_lipid_bind PF093995 -1.10 MSC PF094020 100.00 FadA PF094030 100.00 DUF2003 PF094041 -0.19 Btz PF094050 100.00 DUF2004 PF094060 100.00 DUF2005 PF094075 -0.70 PUB PF094091 -100.00 PagL PF094113 -0.19 XendoU PF094121 -0.19 DUF2008 PF094151 0.51 UPF1_Zn_bind PF094162 0.73 DUF2010 PF094192 -100.00 Nop16 PF094201 -0.19 FRQ PF094210 100.00 WTX PF094221 0.51 PhoD PF094230 100.00 YqeY PF094240 100.00 Nyv1_N PF094260 100.00 DUF2011 PF094281 0.91 Wbp11 PF094292 -0.19 DUF2012 PF094301 0.51 DUF2013 PF094312 -100.00 THP2 PF094322 -100.00 HRP1 PF094330 100.00 DUF2015 PF094350 100.00 Pombe_5TM PF094370 100.00 DUF2017 PF09438

64 -0.66 SRPRB PF094393 -0.19 eIF3_N PF094401 -0.19 DUF2018 PF094421 0.91 CFC PF094431 -0.19 MRC1 PF094445 0.28 Methyltransf_15 PF09445

Sheet1

3 -1.29 VMA21 PF094461 -100.00 Cnl2_NKP2 PF094470 100.00 MmlI PF094481 -100.00 DUF2019 PF094500 100.00 ATG27 PF094510 100.00 Mvb12 PF094522 -0.88 HIRA_B PF094531 -0.19 Vps23_core PF094540 100.00 Cas_DxTHG PF094551 -100.00 RcsC PF094564 0.04 RBD-FIP PF094570 100.00 H_lectin PF094580 100.00 Saf-Nte_pilin PF094600 100.00 PcF PF094610 100.00 Mus7 PF094621 0.91 Opy2 PF094630 100.00 LBR_tudor PF094650 100.00 Yqai PF094664 -0.47 RNase_H2-Ydr279 PF094681 1.20 Cobl PF094690 100.00 Peptidase_M64 PF094711 -0.19 MtrF PF094720 100.00 Dot_icm_IcmQ PF094751 -100.00 Pilus_CpaD PF094762 -0.88 Type_III_YscG PF094770 100.00 CBM49 PF094780 100.00 Flg_new PF094790 100.00 PrgH PF094801 -100.00 HpaP PF094831 -100.00 Cas_TM1802 PF094841 -0.19 CRISPR_Cse2 PF094854 0.51 HrpB7 PF094860 100.00 HrpB2 PF094870 100.00 Osmo_MPGsynth PF094880 100.00 CbtB PF094891 -100.00 CbtA PF094901 -0.19 RE_AlwI PF094910 100.00 DUF2389 PF094931 -100.00 Slx4 PF094942 -100.00 DUF2462 PF094950 100.00 Cenp-O PF094962 -100.00 Med12 PF094976 -1.98 DUF2388 PF094980 100.00 Bac_small_YrzI PF095011 -100.00 RE_Bsp6I PF095041 -100.00 Salt_tol_Pase PF095065 -0.41 CDC27 PF095071 0.51 RNA_lig_T4_1 PF095111 -100.00 ThiW PF095120 100.00 SSXRD PF095140 100.00 RE_CfrBI PF095160 100.00 RE_Eco29kI PF095170 100.00 RE_HindVP PF095191 -100.00 RE_MjaII PF095200 100.00 DUF2390 PF095231 -100.00 Phg_2220_C PF095243 -1.29 DUF2387 PF09526

Sheet1

1 -100.00 ATPase_gene1 PF095271 -100.00 Intg_mem_TP0381 PF095290 100.00 Cas_TM1812 PF095309 -0.08 Ndc1_Nup PF095312 -0.19 DFDF PF095320 100.00 DUF2380 PF095332 -100.00 Trp_oprn_chp PF095340 100.00 Gmx_para_CXXCG PF095353 -100.00 DUF2383 PF095376 -0.03 FYDLN_acid PF095382 -100.00 DUF2385 PF095392 -0.88 FFD_TFG PF095420 100.00 DUF2381 PF095440 100.00 Spore_III_AE PF095461 -100.00 Spore_IV_A PF095473 -100.00 Spore_III_AB PF095481 -100.00 RE_Bpu10I PF095491 -100.00 DUF2376 PF095500 100.00 Spore_II_R PF095510 100.00 RE_BstXI PF095520 100.00 RE_Eco47II PF095531 -100.00 RE_HaeII PF095540 100.00 DUF2375 PF095580 100.00 Cas6 PF095590 100.00 Spore_YunB PF095601 -100.00 RE_NgoFVII PF095650 100.00 RE_SacI PF095660 100.00 RE_MjaI PF095680 100.00 RE_XamI PF095720 100.00 RE_TaqI PF095730 100.00 DUF2374 PF095740 100.00 Spore_SspJ PF095750 100.00 COX9 PF095761 -0.19 Spore_YpjB PF095771 -100.00 Spore_YabQ PF095781 -0.19 Spore_YtfJ PF095790 100.00 Spore_YhcN_YlaJ PF095800 100.00 Spore_III_AF PF095810 100.00 AnfO_nitrog PF095820 100.00 Phageshock_PspG PF095830 100.00 Phageshock_PspD PF095840 100.00 Lin0512_fam PF095858 -1.57 YfhO PF095862 -100.00 PGA_cap PF095871 1.20 YqaJ PF095880 100.00 HrpA_pilin PF095890 100.00 DUF2031 PF095921 -100.00 Pathogen_betaC1 PF095931 -0.19 DUF2029 PF095941 -100.00 Metaviral_G PF095951 -0.19 MamL-1 PF095960 100.00 IGR PF095970 100.00 Stm1_N PF095981 -100.00 IpaC_SipC PF095990 100.00 Cyd_oper_YbgE PF096000 100.00 DUF2459 PF096011 0.51 PhaP_Bmeg PF09602

Sheet1

0 100.00 Potass_KdpF PF096041 -0.19 Trep_Strep PF09605

40 -0.99 Med15 PF096062 0.51 BrkDBD PF096071 -0.19 Alph_Pro_TM PF096080 100.00 Cas_GSU0054 PF096090 100.00 Myco_arth_vir_N PF096100 100.00 Cas_Csy1 PF096112 -0.19 HrpB1_HrpK PF096130 100.00 Cas_Csy2 PF096140 100.00 Cas_GSU0053 PF096170 100.00 Cas_Csy4 PF096180 100.00 YscW PF096190 100.00 LcrR PF096210 100.00 DUF2391 PF096220 100.00 DUF2393 PF096240 100.00 VP9 PF096251 -100.00 DHC PF096260 100.00 YvfG PF096280 100.00 DUF2024 PF096300 100.00 Sen15 PF096310 100.00 DUF2023 PF096330 100.00 DUF2025 PF096340 100.00 MetRS-N PF096353 -1.29 XkdW PF096362 -0.88 Med18 PF096370 100.00 Ph1570 PF096380 100.00 YjcQ PF096391 -100.00 DUF2026 PF096412 -100.00 Mg296 PF096440 100.00 CHZ PF096490 100.00 PHA_gran_rgn PF096502 -0.88 Cas_APE2256 PF096511 -100.00 Cas_VVA1548 PF096520 100.00 DUF2396 PF096540 100.00 PGPGW PF096560 100.00 Cas_Csx8 PF096570 100.00 Cas_Csx9 PF096580 100.00 Cas_Csm6 PF096590 100.00 DUF2397 PF096600 100.00 DUF2398 PF096610 100.00 Phenyl_P_gamma PF096621 -0.19 Amido_AtzD_TrzD PF096630 100.00 Sororin PF096660 100.00 DUF2028 PF096671 2.12 Asp_protease PF096681 -100.00 Phage_pRha PF096691 -0.19 Cas_Cas02710 PF096700 100.00 Spore_GerQ PF096712 0.22 TrbC_Ftype PF096733 -0.19 DUF2400 PF096741 -100.00 Chlamy_scaf PF096752 -100.00 TraV PF096760 100.00 TrbI_Ftype PF096771 -0.19 Caa3_CtaG PF096780 100.00 Tiny_TM_bacill PF096802 -100.00 Phage_rep_org_N PF09681

Sheet1

1 -0.19 Holin_LLH PF096821 -100.00 Tail_P2_I PF096840 100.00 Tic20 PF096853 -1.29 Plasmid_RAQPRD PF096862 -0.88 P_fal_TIGR01639 PF096870 100.00 Wx5_PLAF3D7 PF096881 -100.00 PY_rept_46 PF096890 100.00 PYST-C1 PF096901 0.51 PulS_OutS PF096910 100.00 Arb1 PF096920 100.00 Phage_XkdX PF096930 100.00 Gcw_chp PF096941 -100.00 YtfJ_HI0045 PF096951 -0.19 Ctf8 PF096960 100.00 GSu_C4xC__C2xCH PF096981 -100.00 Paired_CXXCH_1 PF096991 0.51 Cas_Cmr5 PF097010 100.00 Cas_Csa5 PF097020 100.00 Cas_Csa4 PF097031 0.51 Cas_CXXC_CXXC PF097060 100.00 Cas_Cas2CT1978 PF097070 100.00 Trep_dent_lipo PF097100 100.00 PHA_synth_III_E PF097120 100.00 A_thal_3526 PF097130 100.00 Plasmod_dom_1 PF09715

10 -0.88 ETRAMP PF097161 -100.00 Tape_meas_lam_C PF097180 100.00 C_GCAxxG_C_C PF097190 100.00 Unstab_antitox PF097200 100.00 DUF2384 PF09722

51 -0.08 CxxC_CxxC_SSSS PF097231 0.51 DUF2036 PF097241 -0.19 Fra10Ac1 PF09725

51 -0.62 Macoilin PF097261 -0.19 CortBP2 PF097271 0.51 Taxilin PF097281 0.51 Gti1_Pac2 PF097292 0.73 BicD PF09730

13 -0.81 Mitofilin PF097313 -1.29 CactinC_cactus PF097322 -0.19 VEFS-Box PF097332 -0.88 Tau95 PF097341 0.91 Nckap1 PF097352 0.22 Bud13 PF097361 0.51 Det1 PF097373 -0.19 DUF2051 PF097386 -0.19 DUF2044 PF097390 100.00 DUF2043 PF097402 -0.88 DUF2045 PF097412 -0.19 Dymeclin PF097421 -0.19 DUF2042 PF097435 - Jnk-SapK_ap_N PF097442 -0.19 DUF2040 PF097452 -0.19 Membralin PF097462 -0.88 DUF2052 PF097471 -0.19 Med10 PF097481 -0.19 HVSL PF09749

Sheet1

3 -0.59 DRY_EERY PF097501 -100.00 Es2 PF097514 -0.19 DUF2048 PF097523 0.51 Use1 PF097531 -0.19 PAC2 PF097541 0.51 DUF2046 PF097555 - DDRGK PF097561 -0.19 Arb2 PF097572 -0.19 FPL PF097584 0.51 Atx10homo_assoc PF097591 -0.19 KOG2701 PF097623 0.66 Sec3 PF097631 0.51 WDYHV PF097641 -0.19 WD-3 PF09765

12 -0.47 FimP PF097661 -100.00 DUF2053 PF097672 -0.88 Peptidase_M76 PF097686 -0.59 ApoO PF09769

88 -0.98 PAT1 PF097703 -1.29 Tmemb_18A PF097711 0.51 Tmem26 PF097721 -0.19 Meckelin PF097733 -1.29 Cid2 PF097741 0.51 Keratin_assoc PF097752 -0.88 Mitoc_L55 PF097761 -100.00 OSTMP1 PF097772 -100.00 Guanylate_cyc_2 PF097781 0.51 DUF2349 PF097791 -0.19 NDUF_B5 PF097811 -0.19 NDUF_B6 PF097820 100.00 Vac_ImportDeg PF097831 -0.19 L31 PF097841 -100.00 Prp31_C PF097854 0.04 CytochromB561_N PF097863 -0.59 Golgin_A5 PF097871 0.91 Tmemb_55A PF097884 0.22 DUF2353 PF097892 -0.88 Hyccin PF097902 -0.19 Oxidored-like PF097911 -100.00 But2 PF097922 -0.88 AD PF097932 0.22 Avl9 PF097940 100.00 Atg31 PF097951 -100.00 QCR10 PF097961 -0.19 NatB_MDM20 PF097971 0.91 LCD1 PF097983 -1.29 Transmemb_17 PF097991 0.51 SYS1 PF098010 100.00 Sec66 PF098023 -0.59 DUF2346 PF098031 0.51 DUF2347 PF098043 0.51 Nop25 PF098058 -0.19 CDK2AP PF098061 -0.19 DUF2348 PF098071 0.51 SNAPc_SNAP43 PF098081 -0.19 MRP-L27 PF098091 -100.00 Morph_protein1 PF09810

Sheet1

3 -0.59 Yae1_N PF098111 -0.19 MRP-L28 PF098122 -100.00 Coiled-coil_56 PF098134 -1.57 DUF2351 PF098142 0.22 XK-related PF098151 -0.19 EAF PF098161 -0.19 DUF2352 PF098178 -0.66 ABC_ATPase PF098181 -100.00 ABC_cobalt PF098191 -100.00 AAA-ATPase_like PF098200 100.00 ABC_transp PF098212 -0.88 ABC_transp_aux PF098220 100.00 DUF2357 PF098230 100.00 ArsR PF098241 0.51 BPL_N PF098250 100.00 Beta_propel PF098261 -100.00 CRISPR_Cas2 PF098270 100.00 Chrome_Resist PF098280 100.00 DUF2057 PF098295 -100.00 DUF2058 PF098311 0.51 DUF2059 PF098320 100.00 DUF2061 PF098341 -0.19 DUF2062 PF098350 100.00 DUF2063 PF098361 -100.00 DUF2064 PF098370 100.00 DUF2065 PF098380 100.00 DUF2067 PF098401 -100.00 DUF2069 PF098420 100.00 DUF2070 PF098434 -0.88 DUF2072 PF098451 -100.00 DUF2074 PF09847

21 -0.19 DUF2075 PF098484 -0.19 DUF2076 PF098491 -100.00 DUF2077 PF09850

14 -0.88 DUF2078 PF098510 100.00 DUF2079 PF098520 100.00 DUF2082 PF098550 100.00 DUF2083 PF098560 100.00 DUF2085 PF098581 0.91 DUF2086 PF098590 100.00 DUF2087 PF098600 100.00 DUF2088 PF098610 100.00 DUF2089 PF098620 100.00 DUF2094 PF098671 0.91 DUF2095 PF098682 -0.19 DUF2096 PF098691 -0.19 DUF2098 PF098710 100.00 DUF2099 PF098720 100.00 DUF2100 PF098731 1.20 DUF2101 PF098740 100.00 DUF2102 PF098751 0.91 DUF2107 PF098801 -100.00 DUF2108 PF098810 100.00 DUF2110 PF098832 -100.00 DUF2112 PF098850 100.00 DUF2113 PF098861 -100.00 DUF2115 PF09888

Sheet1

3 -0.19 DUF2116 PF098891 -0.19 DUF2118 PF098910 100.00 DUF2119 PF098921 0.51 DUF2120 PF098930 100.00 DUF2121 PF098940 100.00 DUF2122 PF098950 100.00 DUF2124 PF098970 100.00 DUF2126 PF098991 -100.00 DUF2127 PF099000 100.00 DUF2128 PF099011 -0.19 DUF2130 PF099030 100.00 DUF2131 PF099041 -0.19 DUF2132 PF099050 100.00 DUF2136 PF099070 100.00 DUF2139 PF099101 -0.19 DUF2140 PF099110 100.00 DUF2141 PF099121 -100.00 DUF2142 PF099130 100.00 DUF2145 PF099161 -100.00 DUF2147 PF099173 -1.29 DUF2149 PF099190 100.00 DUF2150 PF099200 100.00 DUF2153 PF099214 -0.88 DUF2154 PF099220 100.00 DUF2155 PF099230 100.00 DUF2156 PF099240 100.00 DUF2157 PF099250 100.00 DUF2158 PF099260 100.00 DUF2159 PF099270 100.00 DUF2160 PF099281 0.91 DUF2161 PF099290 100.00 DUF2162 PF099300 100.00 DUF2164 PF099320 100.00 DUF2165 PF099331 -100.00 DUF2167 PF099351 -0.19 DUF2168 PF099361 -100.00 DUF2169 PF099370 100.00 DUF2171 PF099390 100.00 DUF2172 PF099404 -0.88 DUF2175 PF099430 100.00 DUF2178 PF099463 -0.19 DUF2180 PF099470 100.00 DUF2182 PF099482 -0.88 DUF2183 PF099490 100.00 DUF2185 PF099510 100.00 DUF2187 PF099531 -100.00 DUF2188 PF099540 100.00 DUF2189 PF099550 100.00 DUF2191 PF099570 100.00 DUF2192 PF099580 100.00 DUF2193 PF099591 -0.19 DUF2194 PF099600 100.00 DUF2196 PF099620 100.00 DUF2197 PF099630 100.00 DUF2198 PF099640 100.00 DUF2200 PF099669 -0.30 DUF2201 PF09967

Sheet1

0 100.00 DUF2202 PF099684 -0.47 DUF2203 PF099690 100.00 DUF2204 PF09970

11 0.19 DUF2207 PF099722 -100.00 DUF2208 PF099732 -0.88 DUF2209 PF099744 -0.88 DUF2133 PF099761 -100.00 DUF2214 PF099801 -100.00 DUF2218 PF099811 -100.00 DUF2220 PF099830 100.00 DUF2222 PF09984

12 -0.88 DUF2225 PF099860 100.00 DUF2227 PF099880 100.00 DUF2229 PF099890 100.00 DUF2231 PF099903 -100.00 DUF2232 PF099910 100.00 DUF2233 PF099923 -100.00 DUF2235 PF099940 100.00 DUF2238 PF099970 100.00 DUF2239 PF099981 -100.00 DUF2240 PF099991 -0.19 DUF2244 PF100030 100.00 DUF2247 PF100040 100.00 DUF2249 PF100061 -100.00 DUF2250 PF100070 100.00 DUF2251 PF100080 100.00 DUF2252 PF100092 -0.88 DUF2254 PF100114 0.22 DUF2256 PF100131 -100.00 DUF2257 PF100140 100.00 DUF2258 PF100152 -100.00 DUF2259 PF100160 100.00 DUF2260 PF100175 -0.41 Med4 PF100182 -100.00 DUF2265 PF100232 -100.00 DUF2267 PF100251 -100.00 DUF2268 PF100261 -0.19 DUF2269 PF100270 100.00 DUF2270 PF100280 100.00 DUF2271 PF100291 -100.00 DUF2273 PF100310 100.00 Pho88 PF100321 0.51 ATG13 PF100331 -0.19 Dpy19 PF100340 100.00 DUF2179 PF100351 -0.19 RLL PF100362 -0.88 MRP-S27 PF100371 -0.19 DUF2274 PF100380 100.00 DUF2277 PF100410 100.00 DUF2278 PF100420 100.00 DUF2279 PF100433 -100.00 Ret_tiss PF100440 100.00 DUF2280 PF10045

24 -0.53 BLOC1_2 PF100460 100.00 DUF2281 PF100471 -100.00 DUF2283 PF100491 -100.00 DUF2284 PF10050

Sheet1

1 -100.00 DUF2286 PF100510 100.00 DUF2288 PF100520 100.00 DUF2293 PF100562 -100.00 DUF2294 PF100578 -0.66 DUF2296 PF100580 100.00 DUF2299 PF100610 100.00 DUF2300 PF100621 -0.19 DUF2304 PF100662 -0.19 DUF2306 PF100671 0.51 DUF2308 PF100690 100.00 DUF2309 PF100701 -100.00 DUF2310 PF100713 -1.29 DUF2312 PF100730 100.00 DUF2285 PF100747 -0.05 PCI_Csn8 PF100751 -100.00 DUF2313 PF100762 -0.88 DUF2316 PF100780 100.00 DUF2317 PF100792 0.73 DUF2318 PF100800 100.00 DUF2319 PF100817 0.35 DUF2321 PF100831 -0.19 DUF2322 PF100840 100.00 DUF2324 PF100860 100.00 DUF2325 PF100871 0.51 DUF2326 PF100880 100.00 DUF2330 PF100920 100.00 DUF2331 PF100932 -100.00 DUF2333 PF100951 -100.00 DUF2334 PF100961 -100.00 DUF2335 PF100971 -100.00 DUF2336 PF100984 -0.19 RskA PF100992 -0.88 DUF2339 PF101010 100.00 DUF2341 PF101020 100.00 DUF2342 PF101030 100.00 Brr6_like_C_C PF101041 -0.19 DUF2344 PF101051 -0.19 DUF2345 PF101060 100.00 Endonuc_Holl PF101073 -0.19 Exon_PolB PF101080 100.00 FluMu_gp41 PF101090 100.00 GPDPase_memb PF101101 -100.00 GlycosTransf PF101112 -0.19 Halogen_Hydrol PF101120 100.00 Hist_Kin_Sens PF101142 -0.88 Host_attach PF101160 100.00 Metal_hydrol PF101181 -100.00 MethyTransf_Reg PF101190 100.00 MethylPyrKinase PF10120

16 -1.35 Mu-like_Com PF101221 -100.00 Mu-like_gpT PF101241 -100.00 NADHdeh_related PF101250 100.00 Nit_Regul_Hom PF101261 -0.19 Nuc-transf PF101270 100.00 OpgC_C PF101290 100.00 PIN_2 PF101300 100.00 PTPS_related PF10131

Sheet1

2 -100.00 RNA_bind_2 PF101330 100.00 RPA PF101341 -100.00 Rod-binding PF101351 -100.00 SpecificRecomb PF101360 100.00 TIR-like PF101371 0.51 Tellurium_res PF101382 -100.00 Virul_Fac PF101392 0.22 essB PF101400 100.00 ssDNA-exonuc_C PF101410 100.00 PhoPQ_related PF101420 100.00 PhosphMutase PF101431 -0.19 SMP_2 PF101442 -0.88 PhageMin_Tail PF101457 -0.34 zf-C4H2 PF101463 -1.29 CR6_interact PF101472 -0.88 SCHIP-1 PF101481 -0.19 NAcGluc_Transf PF101490 100.00 RNase_E_G PF101501 -0.19 DUF2359 PF10151

11 -0.64 DUF2360 PF101522 0.22 DUF2361 PF101531 -0.19 DUF2362 PF101541 -0.19 DUF2363 PF101552 0.51 Med17 PF101563 -0.19 DUF2365 PF101575 -1.10 LOH1CR12 PF101582 -100.00 MMtag PF101590 100.00 Tmemb_40 PF101601 -0.19 DDDD PF101610 100.00 G8 PF101623 -100.00 EnY2 PF101632 -0.19 DUF2367 PF101644 -0.88 Ric8 PF101652 -100.00 DUF2368 PF101661 1.20 NEP PF101671 0.91 Nup88 PF101682 -0.88 Laps PF101691 -0.19 C6_DPF PF101701 -0.19 DUF2366 PF101711 0.51 DDA1 PF101720 100.00 DUF2343 PF10173

11 -0.39 Cast PF101741 -0.19 MPP6 PF101753 -0.59 DUF2370 PF101763 -1.29 DUF2371 PF101772 -0.88 DUF2372 PF101783 -0.19 DUF2369 PF101791 -0.19 DUF2373 PF101801 -100.00 PIG-H PF101813 -1.29 ESSS PF101831 -0.19 DUF2358 PF101841 -0.19 Mesd PF101852 0.91 DUF2355 PF101861 -0.19 Nefa_Nip30_N PF101871 0.51 Oscp1 PF101880 100.00 DUF2356 PF101891 0.91 Tmemb_170 PF10190

Sheet1

1 -0.19 COG7 PF101914 -0.88 GpcrRhopsn4 PF101921 0.91 Telomere_reg-2 PF101931 -0.19 Phospho_p8 PF101955 -0.70 Cir_N PF101971 0.51 Ada3 PF101981 0.51 Adaptin_binding PF101991 -0.19 Ndufs5 PF102003 0.10 Pet191_N PF102031 0.51 DuoxA PF102042 0.73 KLRAQ PF102053 -1.29 WRW PF102063 -0.59 Armet PF102080 100.00 DUF2340 PF102091 0.51 MRP-S32 PF102103 0.51 Ax_dynein_light PF102111 -0.19 TTKRSYEDQ PF102121 -0.19 MRP-S28 PF102130 100.00 Rrn6 PF102141 -0.19 Ost4 PF102153 0.32 DUF2039 PF102171 -0.19 DUF2054 PF102181 -0.19 DUF2146 PF102202 -0.88 DUF2151 PF102213 -0.59 DUF2152 PF102221 0.51 DUF2181 PF102237 -0.52 DUF2205 PF102247 -1.03 DUF2215 PF102251 -0.19 DUF2216 PF102262 -0.88 DUF2228 PF102283 -0.59 DUF2246 PF10229

16 -0.19 DUF2305 PF102302 -0.19 DUF2315 PF102311 -0.19 Med8 PF102321 -0.19 Cg6151-P PF102337 0.27 Cluap1 PF102347 -0.34 Cript PF102356 -0.88 DAP3 PF102362 0.51 N6-adenineMlase PF102370 100.00 Eapp_C PF102381 -0.19 DUF2465 PF102391 0.51 DUF2464 PF102404 0.37 KxDL PF102416 -0.37 L_HGMIC_fpl PF10242

20 -0.29 MIP-T3 PF102431 -0.19 MRP-L51 PF102441 -0.19 MRP-S22 PF102451 -0.19 MRP-S35 PF102461 -0.19 Romo1 PF102471 -0.19 Mlf1IP PF102482 -100.00 NDUFB10 PF102492 -0.88 O-FucT PF102501 0.51 PEN-2 PF102513 -1.29 PP28 PF102521 -0.19 PRCC_Cterm PF102531 -0.19 Pacs-1 PF102541 0.51 Paf67 PF10255

Sheet1

3 0.10 Erf4 PF102561 0.91 RAI16-like PF102572 -0.88 RNA_GG_bind PF102581 -0.19 Rogdi_lz PF102591 -0.19 SAYSvFN PF102601 0.51 Scs3p PF102613 -1.29 Rdx PF102627 0.06 SprT-like PF102631 0.91 Stork_head PF102644 0.04 DUF2217 PF102651 -0.19 Strumpellin PF102669 -2.38 Tmemb_cc2 PF102671 0.91 Tmemb_161AB PF102683 -1.29 Tmemb_185A PF102691 -0.19 MMgT PF102701 -0.19 Tmp39 PF102712 0.51 Tmpp129 PF102722 -0.19 WGG PF102737 -0.52 ParcG PF102744 -0.19 Peptidase_C65 PF10275

23 -0.61 zf-CHCC PF102766 -0.59 Frag1 PF102773 -0.19 Med19 PF102780 100.00 Latarcin PF102793 -0.19 Med11 PF102803 -1.29 Ish1 PF102813 -0.59 Muc_lac_enz PF102823 -1.29 zf-CCHH PF102830 100.00 Luciferase_3H PF102842 0.51 DUF2392 PF102880 100.00 DUF2403 PF102901 -0.19 SAFF PF102910 100.00 7TM_GPCR_Srab PF102921 -0.19 DUF2405 PF10293

16 -0.39 Methyltransf_16 PF102940 100.00 DUF2406 PF102953 -0.19 DUF2404 PF102961 1.42 IML2 PF103005 -1.80 DUF2407 PF103021 0.91 DUF2408 PF103032 -0.88 DUF2411 PF103040 100.00 Fmp27_SW PF103051 -0.19 DUF2410 PF103071 -100.00 DUF2414 PF10309

10 -0.88 DUF2413 PF103100 100.00 Ilm1 PF103112 -100.00 Cactin_mid PF103121 -0.19 DUF2415 PF103130 100.00 DUF2416 PF103154 -0.19 7TM_GPCR_Srbc PF103160 100.00 7TM_GPCR_Srd PF103170 100.00 7TM_GPCR_Srh PF103180 100.00 7TM_GPCR_Srj PF10319

59 -0.50 7TM_GPCR_Srsx PF103200 100.00 7TM_GPCR_Srt PF103219 0.01 7TM_GPCR_Srv PF10323

23 -0.38 7TM_GPCR_Srw PF10324

Sheet1

0 100.00 7TM_GPCR_Srz PF103252 -100.00 7TM_GPCR_Str PF103260 100.00 7TM_GPCR_Sri PF10327

46 -0.49 7TM_GPCR_Srx PF103280 100.00 DUF2417 PF103290 100.00 Stb3 PF103301 -0.19 DUF2418 PF103320 100.00 DUF2421 PF103341 -100.00 DUF294_C PF103350 100.00 DUF2420 PF103360 100.00 DUF2422 PF103370 100.00 DUF2423 PF103380 100.00 Vel1p PF103397 -0.75 DUF2424 PF103402 0.22 Drmip_Hesp PF103422 -0.19 DUF2419 PF103433 -1.29 Fmp27 PF103442 -0.88 Cohesin_load PF103450 100.00 Con-6 PF103461 -0.19 Fmp27_GFWDK PF103471 0.51 DUF2427 PF103488 -0.88 WWbp PF103493 -0.59 DUF2428 PF103509 -1.29 Apt1 PF103511 -100.00 DUF2430 PF103530 100.00 DUF2431 PF103542 -0.19 Kin17_mid PF103571 -0.19 Eeig1 PF103583 1.02 Fmp27_WPPW PF103591 -100.00 DUF2433 PF103600 100.00 DUF2432 PF103620 100.00 DUF2435 PF103631 -100.00 NKWYS PF103641 -100.00 DUF2436 PF103653 0.10 Vps39_1 PF103664 0.62 Vps39_2 PF103670 100.00 YkyA PF103681 -0.19 ALS_ss_C PF103690 100.00 DUF2437 PF103701 0.91 YojJ PF103720 100.00 EST1_DNA_bind PF103733 0.10 EST1 PF103740 100.00 GRAB PF103750 100.00 Mei5 PF103761 -0.19 ATG11 PF103771 -100.00 RRM PF103780 100.00 nec1 PF103791 -0.19 Autophagy_Cterm PF103811 -0.19 DUF2439 PF103822 -0.19 Scm3 PF103840 100.00 RNA_pol_Rpb2_45 PF103850 100.00 YkuI_C PF103880 100.00 CoatB PF103894 -0.47 ELL PF103900 100.00 DNA_pol_lambd_f PF10391

12 -0.47 COG5 PF103925 -0.41 Matrilin_ccoil PF10393

Sheet1

1 0.51 Hat1_N PF103940 100.00 Utp8 PF103951 -0.19 TrmE_N PF103961 -0.19 ADSL_C PF103972 0.22 DUF2443 PF103981 -0.19 UCR_Fe-S_N PF103991 -0.19 Vir_act_alpha_C PF104004 -0.47 IRF-3 PF104011 0.51 BHD_1 PF104032 -0.88 BHD_2 PF104042 -0.88 BHD_3 PF104052 -0.88 TAF8_C PF104062 -0.19 Ufd2P_core PF104086 -0.59 PTEN_C2 PF104090 100.00 DnaB_bind PF104100 100.00 DsbC_N PF10411

12 -1.29 TrwB_AAD_bind PF104121 -0.19 CysG_dimeriser PF104145 -1.10 FumaraseC_C PF104151 -100.00 IBD PF104168 -1.17 1-cysPrx_C PF104171 -100.00 DHODB_Fe-S_bind PF104180 100.00 TFIIIC_subunit PF104191 -0.19 OAS1_C PF104211 0.51 LRS4 PF104220 100.00 AMNp_N PF104231 0.51 RFC-E_C PF104240 100.00 SdrG_C_C PF104251 -100.00 zf-RAG1 PF104263 -1.29 SOG2 PF104280 100.00 Mtr2 PF104292 0.22 ClpB_D2-small PF104310 100.00 bact-PGI_C PF104322 -100.00 BetaGal_dom2 PF104352 -100.00 BCDHK_Adom3 PF104361 -100.00 Lip_prot_lig_C PF104370 100.00 Cyc-maltodext_C PF104383 -100.00 Bacteriocin_IIc PF104392 -0.88 Urb2 PF104411 -0.19 FIST_C PF104421 -0.19 RNA12 PF104431 -100.00 Nbl1_Borealin_N PF104441 -0.19 DUF2456 PF10445

13 -0.04 DUF2457 PF104462 -0.19 EXOSC1 PF104470 100.00 chaperone_DMP PF104480 100.00 Stn1 PF104510 100.00 TCO89 PF104521 -0.19 NUFIP1 PF104532 -0.19 DUF2458 PF104543 -0.19 BAR_2 PF104552 0.51 BAR_3_WASP_bdg PF104561 -0.19 MENTAL PF104571 -0.19 Val_tRNA-synt_C PF104587 -1.44 Peptidase_S46 PF104591 -100.00 Peptidase_M30 PF104600 100.00 Peptidase_S68 PF10461

Sheet1

2 0.22 Peptidase_M66 PF104620 100.00 Peptidase_U49 PF104631 -100.00 Inhibitor_I34 PF104660 100.00 Inhibitor_I48 PF104670 100.00 Inhibitor_I68 PF104682 0.22 AKAP7_NLS PF104691 0.51 AKAP7_RIRII_bdg PF104707 -100.00 APC_CDC26 PF104710 100.00 CReP_N PF104726 0.51 Cenp-F_leu_zip PF104731 0.51 DUF2451 PF104749 -0.77 DUF2450 PF104751 -100.00 DUF2448 PF104762 -0.88 EIF4E-T PF104771 -0.19 FSA_C PF104791 -0.19 ICAP-1_inte_bdg PF104801 -0.19 Cenp-F_N PF104810 100.00 CtIP_N PF104822 -0.19 Hap2_elong PF104831 -0.19 MRP-S23 PF104842 -0.88 PI3K_1B_p101 PF104862 -100.00 Nup188 PF104872 0.22 PP1c_bdg PF104880 100.00 RFPL3_antisense PF104892 0.73 Nrf1_DNA-bind PF104911 -0.19 Nrf1_activ_bdg PF104921 0.51 Rod_C PF104930 100.00 Stk19 PF104942 -0.19 PACT_coil_coil PF104952 0.51 Syntaxin-18_N PF104960 100.00 zf-4CXXC_R1 PF10497

13 -0.55 IFT57 PF104981 -0.19 Pmp24 PF10499

31 -0.73 SR-25 PF105003 -0.59 Ribosomal_L50 PF105012 -0.19 Peptidase_S26 PF105022 1.20 Esterase_phd PF105031 -0.19 DUF2452 PF105042 -0.88 NARG2_C PF105053 -0.59 MCC-bdg_PDZ PF105061 -100.00 DUF2453 PF10507

12 -0.37 Proteasom_PSMB PF105081 0.91 GalKase_gal_bdg PF105092 -0.88 PIG-S PF105102 -0.88 Borealin PF105128 -1.17 EPL1 PF105131 -0.19 Bcl-2_BAD PF105141 0.51 APP_amyloid PF105158 -0.07 SHNi-TPR PF105163 0.10 DM13 PF105170 100.00 TAT_signal PF105181 0.51 Kua-UEV1_localn PF105202 -100.00 DUF2454 PF105210 100.00 RII_binding_1 PF105223 0.51 BEN PF105231 -0.19 NfI_DNAbd_pre-N PF105243 -0.59 Engrail_1_C_sig PF10525

Sheet1

1 0.51 NADH_ub_rd_NUML PF105261 -100.00 PQQ_N PF105274 -0.88 SLBB PF105310 100.00 Plant_all_beta PF105321 -100.00 Plant_zn_clust PF105330 100.00 CRIC_ras_sig PF105340 100.00 PQQ_C PF105352 0.51 WAC_Acf1_DNA_bd PF105373 -0.59 Membr_traf_MHD PF105405 -0.70 KASH PF105415 -100.00 Vitelline_membr PF105421 -0.19 ORF6N PF105430 100.00 T5orf172 PF10544

56 -0.34 MADF_DNA_bdg PF105451 -0.19 P63C PF105461 -100.00 P22_AR_C PF105480 100.00 ORF11CD3 PF105490 100.00 MULE PF105511 0.51 ORF6C PF105520 100.00 MSV199 PF105536 -0.03 Cullin_Nedd8 PF105571 -0.19 MTP18 PF105582 -0.88 Plug_translocon PF105592 -0.88 UPF0565 PF105611 -0.19 CaM_bdg_C0 PF105620 100.00 MAR_sialic_bdg PF105642 -100.00 NMDAR2_C PF105651 -100.00 Nab6_mRNP_bdg PF105672 -0.19 Tom37 PF105685 -0.70 Thiol-ester_cl PF105698 -0.32 UPF0547 PF105710 100.00 UPF0556 PF105722 0.22 UPF0561 PF105731 -100.00 EndIII_4Fe-2S PF10576

11 -1.20 UPF0560 PF105774 0.51 Rapsyn_N PF105791 -100.00 Neuromodulin_N PF105800 100.00 Synapsin_N PF105810 100.00 Connexin_CCC PF105820 100.00 Involucrin_N PF10583

12 -0.27 Proteasome_A_N PF105845 -0.70 UBA_e1_thiolCys PF105853 0.32 EF-1_beta_acid PF105873 0.10 NADH-G_4Fe-4S_3 PF105883 0.10 NADH_4Fe-4S PF105893 -1.29 PNPOx_C PF10590

35 -0.75 SPARC_Ca_bdg PF105910 100.00 AIPR PF105920 100.00 Z1 PF105930 100.00 UPF0564 PF105951 -0.19 U6-snRNA_bdg PF105962 -0.88 U5_2-snRNA_bdg PF105971 0.51 RRM_4 PF105980 100.00 PDZ_assoc PF10600

20 -0.99 zf-LITAF-like PF1060117 -0.46 RPN7 PF106022 -0.88 Polyketide_cyc2 PF10604

Sheet1

0 100.00 GluR_Homer-bdg PF106065 -1.80 RanBPM_CRA PF106070 100.00 MAGUK_N_PEST PF106083 -0.19 ParA PF106090 100.00 Tafi-CsgC PF106100 100.00 Spore-coat_CotZ PF10612

21 -0.40 Lig_chan-Glu_bd PF106130 100.00 DUF2470 PF106151 -0.19 Tail_tube PF106180 100.00 MdcG PF106200 100.00 FpoO PF106210 100.00 Ehbp PF106220 100.00 PilI PF106231 -100.00 TraS PF106242 -100.00 TraO PF106260 100.00 CotE PF106282 -0.19 DUF2475 PF106290 100.00 DUF2477 PF106310 100.00 He_PIG_assoc PF106321 -100.00 NPCBM_assoc PF106330 100.00 Iron_transport PF106340 100.00 DisA-linker PF106350 100.00 hemP PF106360 100.00 Ofd1_CTDD PF106371 -0.19 Sfi1_C PF106383 -0.59 UPF0546 PF106391 -100.00 Pox_ATPase-GT PF106404 -100.00 Tom5 PF106421 -100.00 Cytochrome-c551 PF106437 -0.75 Misat_Myo_SegII PF106440 100.00 Carb_bind PF106450 100.00 Germane PF106461 -0.19 Gmad1 PF106471 -100.00 DUF2478 PF106492 -0.88 zf-C3H1 PF106500 100.00 DUF2479 PF106510 100.00 DUF2480 PF106521 -100.00 DUF2481 PF106541 -100.00 DUF2482 PF106551 -100.00 RC-P840_PscD PF106570 100.00 DUF2484 PF106583 -100.00 Trypan_glycop_C PF106592 -0.19 MitoNEET_N PF106602 -0.88 EssA PF10661

50 -0.88 PduV-EutP PF106620 100.00 EsxB PF106630 100.00 NdhM PF106640 100.00 Phage_Gp9 PF106651 -100.00 DUF2486 PF106671 -0.19 Phage_terminase PF106682 -0.88 Phage_Gp23 PF106691 -0.19 NikM PF106700 100.00 TcpQ PF106711 -100.00 DUF2487 PF106730 100.00 Ycf54 PF106740 100.00 DUF2489 PF106752 -100.00 gerPA PF10676

Sheet1

0 100.00 DUF2492 PF106781 -100.00 DUF2491 PF106790 100.00 RRN9 PF106801 0.51 Rot1 PF106811 -100.00 Hermes_DBD PF106830 100.00 KGG PF106851 -0.19 DUF2493 PF106860 100.00 Imp-YgjV PF106880 100.00 DUF2496 PF106892 -0.19 Myticin-prepro PF106900 100.00 DUF2497 PF106911 0.51 DUF2500 PF106940 100.00 DUF2501 PF106960 100.00 DUF2507 PF107020 100.00 MoaF PF107031 -100.00 DUF2508 PF107041 -100.00 Ycf15 PF107050 100.00 Aminoglyc_resit PF10706

16 -0.19 YrbL-PhoP_reg PF107070 100.00 DUF2510 PF107081 -100.00 DUF2511 PF107090 100.00 DUF2512 PF107100 100.00 DUF2513 PF107110 100.00 NAD-GH PF107120 100.00 DUF2509 PF107132 -100.00 LEA_6 PF107140 100.00 REGB_T4 PF107150 100.00 NdhL PF107168 -0.88 ODV-E18 PF107171 -0.19 ComFB PF107192 -0.88 DUF2514 PF107210 100.00 YbjN PF107221 -0.19 RepB-RCR_reg PF107231 -100.00 DUF2516 PF107240 100.00 DUF2518 PF107262 -0.88 Rossmann-like PF107270 100.00 DUF2520 PF107280 100.00 CedA PF107290 100.00 DUF2521 PF107303 -100.00 Anophelin PF107311 0.51 DUF2524 PF107322 -100.00 DUF2525 PF107330 100.00 DUF2526 PF107350 100.00 DUF2527 PF107360 100.00 GerPC PF10737

11 -1.89 Lpp-LpqN PF107381 -100.00 DUF2550 PF107390 100.00 DUF2529 PF107400 100.00 GspM_II PF107412 -0.88 Med1 PF107440 100.00 DUF2530 PF107450 100.00 Phage_holin_6 PF107460 100.00 DUF2522 PF107471 -100.00 DUF2531 PF107480 100.00 DUF2534 PF107492 -100.00 DUF2536 PF107500 100.00 DUF2535 PF10751

Sheet1

0 100.00 DUF2533 PF107521 -100.00 DUF2566 PF107530 100.00 DUF2569 PF107540 100.00 DUF2585 PF107550 100.00 DUF2587 PF107590 100.00 DUF2590 PF107613 -0.19 DUF2583 PF107621 0.51 Gin PF107640 100.00 DUF2591 PF107650 100.00 DUF2593 PF107670 100.00 FliX PF107680 100.00 DUF2594 PF107691 -0.19 DUF2596 PF107700 100.00 DUF2582 PF107711 -0.19 DUF2597 PF107721 -0.19 BssS PF107740 100.00 ATP_sub_h PF107750 100.00 DUF2600 PF107760 100.00 YlaC PF107771 -100.00 DehI PF107781 1.61 XhlA PF107791 -100.00 MRP_L53 PF107800 100.00 DUF2602 PF107820 100.00 DUF2599 PF107831 -100.00 YfmQ PF107870 100.00 DUF2603 PF107881 -100.00 Phage_RpbA PF107890 100.00 DUF2604 PF107901 -0.19 DUF2605 PF107920 100.00 Gloverin PF107930 100.00 DUF2606 PF107940 100.00 DUF2607 PF107951 -100.00 Anti-adapt_IraP PF107961 -100.00 YmgB PF107980 100.00 YliH PF107990 100.00 DUF2528 PF108001 -100.00 DUF2540 PF108020 100.00 DUF2539 PF108030 100.00 DUF2538 PF108043 0.10 DUF2730 PF108050 100.00 DUF2542 PF108081 0.51 DUF2732 PF108091 -100.00 DUF2532 PF108110 100.00 DUF2561 PF108121 -100.00 DUF2733 PF108130 100.00 DUF2562 PF108140 100.00 DUF2760 PF108161 -100.00 DUF2547 PF108181 -100.00 DUF2564 PF108190 100.00 DUF2543 PF108201 -100.00 DUF2567 PF108211 -100.00 DUF2568 PF108230 100.00 DUF2580 PF108242 -0.88 DUF2752 PF108250 100.00 DUF2551 PF108261 -0.19 DUF2552 PF108270 100.00 DUF2570 PF10828

Sheet1

0 100.00 DUF2554 PF108292 -100.00 DUF2572 PF108331 -0.19 DUF2560 PF108340 100.00 DUF2573 PF108353 -100.00 DUF2574 PF108361 -100.00 DUF2575 PF108370 100.00 DUF2677 PF108380 100.00 DUF2647 PF108390 100.00 DUF2644 PF108412 -100.00 DUF2642 PF108420 100.00 DUF2578 PF108431 0.51 DUF2576 PF108451 0.51 DUF2722 PF108460 100.00 DUF2656 PF108471 -0.19 DUF2654 PF108490 100.00 DUF2653 PF108503 -100.00 DUF2652 PF108510 100.00 DUF2651 PF108521 -0.19 DUF2650 PF108531 -100.00 DUF2649 PF108540 100.00 DUF2648 PF108551 -100.00 DUF2660 PF108591 -100.00 DUF2661 PF108601 -100.00 DUF2784 PF108610 100.00 DUF2662 PF108620 100.00 DUF2702 PF108631 -100.00 DUF2663 PF108641 0.51 DUF2703 PF108650 100.00 DUF2704 PF108661 -0.19 DUF2664 PF108671 -100.00 DUF2667 PF108682 -100.00 DUF2666 PF108691 -100.00 DUF2729 PF108700 100.00 DUF2740 PF108720 100.00 DUF2668 PF108734 -0.47 DUF2746 PF108741 -100.00 DUF2670 PF108750 100.00 DUF2669 PF108761 0.51 DUF2671 PF108770 100.00 DUF2672 PF108780 100.00 DUF2674 PF108790 100.00 DUF2673 PF108801 -100.00 DUF2679 PF108820 100.00 DUF2681 PF108830 100.00 DUF2683 PF108840 100.00 DUF2684 PF108850 100.00 DUF2685 PF108861 -100.00 DUF2719 PF108912 -100.00 DUF2688 PF108920 100.00 DUF2724 PF108931 -0.19 DUF2714 PF108960 100.00 DUF2716 PF108982 -100.00 DUF2743 PF108990 100.00 DUF2693 PF109020 100.00 DUF2691 PF109030 100.00 DUF2694 PF109041 0.51 DUF2695 PF10905

Sheet1

0 100.00 DUF2697 PF109062 0.51 DUF2749 PF109071 -100.00 DUF2778 PF109081 0.51 DUF2682 PF109090 100.00 DUF2744 PF109100 100.00 DUF2717 PF109111 -100.00 DUF2700 PF109120 100.00 DUF2706 PF109134 -100.00 DUF2708 PF109170 100.00 DUF2718 PF109180 100.00 DUF2699 PF109190 100.00 DUF2705 PF109200 100.00 DUF2745 PF109220 100.00 DUF2791 PF109230 100.00 DUF2711 PF109243 -0.59 DUF2680 PF109251 -100.00 DUF2800 PF109260 100.00 DUF2738 PF109271 -100.00 DUF2810 PF109280 100.00 DUF2735 PF109310 100.00 DUF2783 PF109320 100.00 DUF2827 PF109330 100.00 DUF2634 PF109340 100.00 DUF2637 PF109350 100.00 DUF2638 PF109371 -100.00 YfdX PF109380 100.00 DUF2631 PF109391 0.51 DUF2618 PF109400 100.00 DUF2620 PF109410 100.00 DUF2632 PF109430 100.00 DUF2630 PF109440 100.00 DUF2625 PF109463 -100.00 DUF2628 PF109470 100.00 DUF2776 PF109510 100.00 DUF2753 PF109522 -100.00 DUF2754 PF109531 -0.19 DUF2755 PF109544 -0.88 DUF2757 PF109550 100.00 DUF2756 PF109560 100.00 DUF2758 PF109570 100.00 DUF2759 PF109581 1.89 DUF2762 PF109604 -0.88 DUF2763 PF109610 100.00 DUF2767 PF109651 -100.00 DUF2768 PF109660 100.00 DUF2771 PF109690 100.00 DUF2773 PF109710 100.00 DUF2804 PF109740 100.00 DUF2802 PF109750 100.00 DUF2797 PF109770 100.00 DUF2785 PF109780 100.00 DUF2788 PF109813 -100.00 DUF2789 PF109820 100.00 DUF2794 PF109840 100.00 DUF2805 PF109851 0.51 DUF2796 PF109861 -100.00 DUF2807 PF10988

Sheet1

1 -100.00 DUF2808 PF109891 -100.00 DUF2809 PF109900 100.00 DUF2815 PF109910 100.00 DUF2816 PF109920 100.00 DUF2818 PF109930 100.00 DUF2817 PF109941 -100.00 DUF2819 PF109954 -0.19 Beta-Casp PF109961 -100.00 DUF2838 PF109980 100.00 DUF2839 PF109991 -100.00 DUF2840 PF110000 100.00 DUF2841 PF110011 0.51 RDM PF110021 -100.00 DUF2842 PF110030 100.00 DUF2843 PF110041 -0.19 CotJA PF110070 100.00 DUF2846 PF110080 100.00 DUF2847 PF110091 -100.00 DUF2848 PF110100 100.00 DUF2849 PF110110 100.00 DUF2850 PF110121 -0.19 DUF2852 PF110141 -100.00 DUF2853 PF110150 100.00 DUF2854 PF110161 -0.19 DUF2855 PF11017

17 -1.92 Cuticle_3 PF110180 100.00 DUF2608 PF110190 100.00 DUF2610 PF110200 100.00 DUF2613 PF110210 100.00 DUF2611 PF110220 100.00 DUF2614 PF110230 100.00 DGF-1_4 PF110240 100.00 GP40 PF110253 0.10 DUF2721 PF110262 -0.19 DUF2615 PF110271 -100.00 DUF2723 PF110281 0.51 DAZAP2 PF110290 100.00 Nucleocapsid-N PF110300 100.00 Phage_holin_T PF110310 100.00 ApoM PF110321 -100.00 ComJ PF110330 100.00 DUF2823 PF110341 -100.00 DUF2824 PF110391 0.51 DGF-1_C PF110402 -0.19 DUF2856 PF110432 -100.00 TMEMspv1-c74-12 PF110440 100.00 HycA_repressor PF110461 -100.00 SopD PF110470 100.00 KSHV_K1 PF110490 100.00 Viral_env_E26 PF110501 -0.19 Mannosyl_trans3 PF110511 -100.00 Tr-sialidase_C PF110521 -100.00 Gsf2 PF110550 100.00 UvsY PF110560 100.00 Cortexin PF110570 100.00 Ral PF110580 100.00 DUF2865 PF11064

Sheet1

0 100.00 DUF2866 PF110650 100.00 DUF2868 PF110675 - DUF2869 PF110685 -0.70 DUF2870 PF110690 100.00 DUF2871 PF110701 -100.00 DUF2872 PF110712 -0.88 DUF2779 PF110741 -100.00 YbhQ PF110761 -0.19 DUF2616 PF110774 -0.47 Optomotor-blind PF110781 -100.00 DUF2622 PF110802 -0.88 DUF2890 PF110812 0.73 Streptin-Immun PF110832 -0.19 DUF2621 PF110840 100.00 YqhR PF110850 100.00 DUF2881 PF110870 100.00 RL11D PF110880 100.00 DUF2833 PF110900 100.00 Alveol-reg_P311 PF110920 100.00 Mitochondr_Som1 PF110931 -0.19 UL11 PF110941 -0.19 Gemin7 PF110951 -0.19 Chlorosome_CsmC PF110981 -0.19 M11L PF110991 -0.19 DUF2884 PF111010 100.00 Competence_A PF111042 -0.88 CCAP PF111050 100.00 FANCF PF111070 100.00 Phage_hub_GP28 PF111101 0.51 CENP-M PF111110 100.00 PyocinActivator PF111120 100.00 Phage_head_chap PF111131 -100.00 Minor_capsid PF111140 100.00 DUF2624 PF111160 100.00 DUF2627 PF111180 100.00 DUF2633 PF111191 -0.19 DUF2636 PF111201 -100.00 Spore-coat_CotD PF111220 100.00 DNA_Packaging_2 PF111230 100.00 DUF2830 PF111251 -100.00 Phage_DsbA PF111260 100.00 DUF2892 PF111270 100.00 Nucleocap_ssRNA PF111280 100.00 EIAV_Rev PF111290 100.00 TraC_F_IV PF111302 -100.00 PhrC_PhrF PF111310 100.00 SplA PF111320 100.00 Phage_stabilise PF111341 0.51 DUF2909 PF111370 100.00 DUF2911 PF111381 -100.00 DUF2910 PF111392 -0.88 DUF2913 PF111400 100.00 DUF2914 PF111410 100.00 DUF2917 PF111421 0.51 DUF2919 PF111433 -0.59 DUF2920 PF111440 100.00 DUF2905 PF11146

Sheet1

1 -100.00 DUF2922 PF111481 -0.19 DUF2924 PF111492 -0.88 DUF2927 PF111501 -0.19 DUF2929 PF111510 100.00 DUF2930 PF111521 -100.00 DUF2931 PF111531 -0.19 DUF2937 PF111571 -100.00 DUF2938 PF111580 100.00 DUF2939 PF111590 100.00 DUF2945 PF111600 100.00 DUF2944 PF11161

10 -1.80 DUF2946 PF111620 100.00 DUF2947 PF111630 100.00 DUF2948 PF111643 0.10 DUF2951 PF111660 100.00 DUF2953 PF111671 -100.00 DUF2955 PF111680 100.00 DUF2956 PF111690 100.00 DUF2958 PF111710 100.00 DUF2959 PF111722 -0.19 DUF2970 PF111740 100.00 DUF2961 PF111751 -100.00 DUF2962 PF111761 -0.19 DUF2964 PF111770 100.00 DUF2963 PF111782 -100.00 DUF2967 PF111792 1.32 DUF2968 PF111801 -0.19 YflT PF111813 -100.00 PmrD PF111830 100.00 DUF2969 PF111840 100.00 DUF2971 PF111850 100.00 DUF2972 PF11186

10 -0.88 DUF2974 PF111874 -100.00 DUF2975 PF111880 100.00 DUF2973 PF111892 -100.00 DUF2976 PF111900 100.00 DUF2782 PF111910 100.00 DUF2825 PF111940 100.00 DUF2834 PF111960 100.00 DUF2835 PF111970 100.00 DUF2857 PF111980 100.00 DUF2891 PF111990 100.00 DUF2981 PF112000 100.00 DUF2982 PF112011 -0.19 DUF2983 PF112021 -100.00 DUF2984 PF112032 -0.88 DUF2985 PF112040 100.00 DUF2988 PF112062 -100.00 DUF2989 PF112071 -0.19 DUF2992 PF112080 100.00 DUF2997 PF112111 -0.19 DUF2999 PF112121 1.76 Med2 PF112141 -100.00 DUF3010 PF112150 100.00 DUF3012 PF112160 100.00 DUF3013 PF112170 100.00 DUF3014 PF11219

Sheet1

0 100.00 DUF3015 PF112200 100.00 Med21 PF112210 100.00 DUF3017 PF112220 100.00 DUF3023 PF112241 -100.00 DUF3022 PF112262 -100.00 DUF3025 PF112270 100.00 DUF3027 PF112281 -100.00 DUF3028 PF112292 -0.88 Med25 PF112321 -0.19 DUF3035 PF112334 -0.88 DUF3036 PF112340 100.00 DUF3037 PF112360 100.00 DUF3038 PF112370 100.00 DUF3039 PF112382 0.73 DUF3040 PF112391 0.51 DUF3042 PF112402 0.73 DUF3043 PF112410 100.00 DUF2774 PF112421 -100.00 DUF3045 PF112432 -100.00 Med25_NR-box PF112440 100.00 Phage_gp53 PF112461 -100.00 DUF2675 PF112470 100.00 DUF3049 PF112500 100.00 DUF3050 PF112510 100.00 DUF3052 PF112531 -0.19 DUF3053 PF112540 100.00 DUF3055 PF112560 100.00 DUF3048 PF112580 100.00 DUF3060 PF112590 100.00 Spidroin_MaSp PF112607 -1.44 IRF-2BP1_2 PF112611 0.91 Tho2 PF112620 100.00 Attachment_P66 PF112630 100.00 ThylakoidFormat PF112641 -0.19 Med25_VWA PF112650 100.00 DUF3066 PF112660 100.00 DUF3067 PF112670 100.00 DUF3071 PF112682 -100.00 DUF3068 PF112710 100.00 DUF3073 PF112730 100.00 DUF3074 PF112742 -0.88 Med24_N PF112771 -100.00 DUF3080 PF112790 100.00 DUF3081 PF112800 100.00 DUF3082 PF112820 100.00 DUF3086 PF112851 -100.00 DUF3087 PF112860 100.00 DUF3088 PF112875 -100.00 DUF3089 PF112881 -100.00 DUF3092 PF112890 100.00 DUF3090 PF112901 0.51 DUF3091 PF112910 100.00 DUF3093 PF112921 -100.00 DUF3094 PF112931 -0.19 DUF3095 PF112942 -0.88 DUF3096 PF112950 100.00 DUF3098 PF11297

Sheet1

0 100.00 DUF3099 PF112981 -100.00 DUF3104 PF113023 -0.59 DUF3105 PF113031 1.61 DUF3106 PF113041 -100.00 DUF3107 PF113051 -100.00 DUF3112 PF113090 100.00 DUF3115 PF113123 -100.00 DUF3117 PF113141 0.51 Med30 PF113150 100.00 DUF3118 PF113161 -100.00 DUF3119 PF113170 100.00 DUF3123 PF113210 100.00 DUF3125 PF113230 100.00 DUF3126 PF113240 100.00 DUF3127 PF113253 -1.29 DUF3128 PF113260 100.00 DUF3129 PF113270 100.00 DUF3130 PF113280 100.00 DUF3132 PF113300 100.00 DUF3133 PF113310 100.00 DUF3134 PF113320 100.00 DUF3135 PF113330 100.00 DUF3136 PF113341 -100.00 DUF3137 PF113353 -0.59 DUF3138 PF113361 0.51 DUF3139 PF113370 100.00 DUF3140 PF113381 -100.00 DUF3141 PF113391 -100.00 DUF3144 PF113420 100.00 DUF3146 PF113442 -0.88 DUF3149 PF113460 100.00 DUF3148 PF113470 100.00 DUF3152 PF113501 -100.00 DUF3154 PF113510 100.00 DUF3155 PF113521 -100.00 DUF3153 PF113531 -100.00 DUF3156 PF113541 -0.19 DUF3157 PF113551 -100.00 Pilus_PilP PF113561 -100.00 Spy1 PF113570 100.00 DUF3158 PF113582 0.73 gpUL132 PF113590 100.00 DUF3110 PF113600 100.00 DUF3161 PF113620 100.00 DUF3165 PF113642 0.22 DUF3166 PF113651 -100.00 DUF3168 PF113677 -1.03 DUF3169 PF113684 -1.57 DUF3173 PF113720 100.00 DUF3175 PF113731 -100.00 DUF3176 PF113740 100.00 DUF3179 PF113762 -100.00 DUF3180 PF113770 100.00 DUF3181 PF113780 100.00 DUF3182 PF113791 0.51 DUF3184 PF113800 100.00 DUF3185 PF11381

Sheet1

1 -0.19 DUF3186 PF113820 100.00 DUF3188 PF113840 100.00 DUF3189 PF113851 0.51 VERL PF113860 100.00 DUF2795 PF113870 100.00 FdsD PF113900 100.00 DUF2798 PF113910 100.00 DUF2877 PF113920 100.00 IcmL PF113930 100.00 DUF2873 PF113950 100.00 DUF2874 PF113963 -0.59 GlcNAc PF113970 100.00 DUF2813 PF113980 100.00 DUF3192 PF113990 100.00 Tetrabrachion PF114011 -100.00 Antifungal_prot PF114020 100.00 Potassium_chann PF114042 -100.00 Inhibitor_I67 PF114050 100.00 RestrictionMunI PF114072 -100.00 Helicase_Sgs1 PF114081 -0.19 SARA PF114090 100.00 Antifungal_pept PF114101 -0.19 DNA_ligase_IV PF114112 -0.88 Suppressor_APC PF114140 100.00 Inhibitor_G39P PF114171 -100.00 Scaffolding_pro PF114181 -100.00 DUF3194 PF114190 100.00 Synthase_beta PF114211 -100.00 IBP39 PF114220 100.00 Repressor_Mnt PF114231 -100.00 DUF3195 PF114240 100.00 Toxin_BmKK4 PF114250 100.00 Tc3_transposase PF114270 100.00 DUF3196 PF114280 100.00 Colicin_D PF114291 -0.19 EGL-1 PF114301 -100.00 CHIPS PF114340 100.00 DUF3200 PF114393 -100.00 DUF2828 PF114430 100.00 DUF2895 PF114440 100.00 DUF2894 PF114452 -0.88 DUF2897 PF114460 100.00 DUF3201 PF114471 -100.00 DUF3005 PF114480 100.00 DUF2899 PF114492 -100.00 DUF3008 PF114501 -100.00 DUF3202 PF114510 100.00 DUF3000 PF114520 100.00 DUF2950 PF114531 -0.19 DUF3016 PF114540 100.00 DUF3018 PF114551 -0.19 DUF3021 PF114570 100.00 Mistic PF114580 100.00 DUF2893 PF114590 100.00 DUF3007 PF114601 0.51 RILP PF114610 100.00 R-HINP1I PF11463

Sheet1

1 0.51 Rbsn PF1146417 -0.25 Receptor_2B4 PF114651 -100.00 Doppel PF114662 0.22 LEDGF PF114671 -100.00 PTase_Orf2 PF114681 -100.00 DUF3204 PF114699 -1.29 TUG PF114700 100.00 DUF3205 PF114711 -100.00 DUF3206 PF114721 0.51 B2 PF114730 100.00 N-Term_TEN PF114740 100.00 VP_N-CPKC PF114750 100.00 TgMIC1 PF114760 100.00 Tachystatin_B PF114780 100.00 ImmE5 PF114800 100.00 DUF3208 PF114821 -100.00 DUF3209 PF114830 100.00 DUF3211 PF114857 -0.52 Lge1 PF114880 100.00 DUF3210 PF114891 -100.00 DNA_pol3_alph_N PF114900 100.00 DUF3213 PF114910 100.00 Dicistro_VP4 PF114921 0.51 Ta0938 PF114940 100.00 Regulator_TrmB PF114956 -0.37 HDA2-3 PF11496

14 -2.13 Activator_LAG-3 PF114980 100.00 DUF3214 PF114992 -100.00 Cut12 PF115001 0.51 BCL9 PF115020 100.00 DUF3215 PF115031 -0.19 DUF3216 PF115051 -0.19 DUF3218 PF115080 100.00 FA_FANCE PF115102 -100.00 RhodobacterPufX PF115110 100.00 TA0956 PF115130 100.00 DUF3219 PF115141 -0.19 Cul7 PF115150 100.00 DUF3220 PF115161 -100.00 Nab2 PF115170 100.00 DUF3221 PF115180 100.00 DUF3222 PF115191 -100.00 Cren7 PF115201 -0.19 TFIIE-A_C-term PF115210 100.00 Pik1 PF115221 -0.19 DUF3223 PF115230 100.00 CopK PF115250 100.00 CFIA_Pcf11 PF115262 -0.88 ARL2_Bind_BART PF115270 100.00 AvrL567-A PF115291 -100.00 Pilin_PilX PF115301 -0.19 CARM1 PF115310 100.00 HTHP PF115341 -100.00 DUF3226 PF115362 -0.88 Snurportin1 PF115380 100.00 DUF3228 PF115395 -1.80 Dynein_IC2 PF11540

Sheet1

1 -100.00 Mdv1 PF115423 0.10 UN_NPL4 PF115431 -0.19 Spc42p PF115441 -100.00 HemeBinding_Shp PF115451 -100.00 E3_UbLigase_EDD PF115470 100.00 Receptor_IA-2 PF115481 -100.00 DUF3230 PF115521 -0.19 DUF3231 PF115530 100.00 DUF3232 PF115540 100.00 EBA-175_VI PF115560 100.00 DUF3233 PF11557

18 0.14 ADIP PF115591 -100.00 LAP2alpha PF115601 -100.00 Saw1 PF115611 -0.19 EDC3_LSm PF115621 -100.00 Protoglobin PF115630 100.00 BpuJI_N PF115640 100.00 PorB PF115654 -0.88 Inhibitor_PI31 PF115662 -0.88 Med29 PF11568

18 -0.51 Homez PF115690 100.00 E2R135 PF115704 -0.88 Med27 PF115711 -100.00 DUF3234 PF115721 0.91 Med23 PF115730 100.00 DUF3235 PF115740 100.00 FhuF_C PF115751 -100.00 DUF3236 PF115761 -0.19 NEMO PF115770 100.00 DUF3239 PF115801 0.51 Argos PF115811 -100.00 Toxin_ToxA PF115840 100.00 Stomoxyn PF115851 -100.00 DUF3242 PF115860 100.00 Prion_bPrPp PF115870 100.00 DUF3243 PF115880 100.00 DUF3244 PF115890 100.00 DNAPolymera_Pol PF11590

29 -1.16 Med3 PF115931 -0.19 Med28 PF115940 100.00 DUF3245 PF115952 -0.88 DUF3246 PF115961 -0.19 Med13_N PF115971 0.91 COMP PF115980 100.00 CAF-1_p150 PF116002 -0.19 Shal-type PF116010 100.00 Sir1 PF116030 100.00 CusF_Ec PF116044 -0.19 Vps36_ESCRT-II PF116050 100.00 DUF3247 PF11607

11 -0.98 Limkain-b1 PF116080 100.00 Ste5 PF116101 -100.00 TRF2 PF116111 -0.19 Bre5 PF116141 0.51 EZH2_WD-Binding PF116160 100.00 Cu-binding_MopE PF116170 100.00 DUF3250 PF11618

Sheet1

2 -100.00 P53_C PF116193 0.10 GABP-alpha PF116201 -100.00 Sbi-IV PF116212 -100.00 DUF3251 PF116220 100.00 DUF3252 PF116230 100.00 DUF3253 PF116251 -100.00 Rap1_C PF116260 100.00 TCR_zetazeta PF116284 -0.88 Mst1_SARAH PF116290 100.00 DUF3254 PF116300 100.00 Nsp3 PF116332 -0.88 Med16 PF116350 100.00 Troponin-I_N PF116360 100.00 UvsW PF116371 -0.19 DnaA_N PF116381 0.51 TAN PF116401 -100.00 Antigen_Bd37 PF116411 0.51 Blo-t-5 PF116420 100.00 VASP PF116431 -100.00 DUF3256 PF116441 -100.00 PMT_C PF116472 -0.19 RIG-I_C-RD PF116480 100.00 T4_neck-protein PF116490 100.00 P22_Tail-4 PF116500 100.00 DUF3259 PF116521 -100.00 VirionAssem_T7 PF116530 100.00 DUF2665 PF116540 100.00 ComReg_Spx PF116562 -0.88 Activator-TraM PF116570 100.00 DUF3260 PF116580 100.00 DUF3261 PF116591 -0.19 DUF2986 PF116611 -0.19 DUF3265 PF116652 -100.00 DUF3267 PF11667

10 -0.54 WBP-1 PF116694 -0.88 Apis_Csd PF116710 100.00 DUF3268 PF116720 100.00 DUF3270 PF116740 100.00 DUF3271 PF116751 -100.00 DUF3272 PF116764 -1.57 DUF3275 PF116792 0.22 DUF3276 PF116802 0.22 DUF3279 PF116821 -0.19 DUF3278 PF116830 100.00 DUF3281 PF116850 100.00 DUF3284 PF116870 100.00 DUF3285 PF116880 100.00 DUF3286 PF116891 -100.00 DUF3287 PF116900 100.00 DUF3288 PF116910 100.00 DUF3289 PF116921 -0.19 DUF2990 PF116931 -100.00 DUF3290 PF116941 -100.00 DUF3291 PF116952 -100.00 DUF3292 PF116960 100.00 DUF3293 PF116978 -0.19 V-ATPase_H_C PF11698

Sheet1

6 -1.29 ATG22 PF117005 -0.41 UNC45-central PF117012 -0.88 DUF3295 PF117021 -100.00 UPF0506 PF117033 -0.59 Folliculin PF117047 -0.34 RNA_pol_3_Rpc31 PF117050 100.00 zf-CGNR PF117063 -1.29 Npa1 PF117071 0.51 Slu7 PF117080 100.00 Mit_ribos_Mrp51 PF117091 -0.19 Git3 PF117105 0.51 Tim54 PF117116 -0.37 Vma12 PF117120 100.00 Peptidase_C80 PF117133 -0.59 Inhibitor_I53 PF11714

31 -0.22 Nup160 PF117150 100.00 MDMPI_N PF117168 -0.07 Tudor-knot PF117172 0.22 CPSF73-100_C PF117181 -100.00 Drc1-Sld2 PF117190 100.00 Inhibitor_I78 PF117202 -100.00 Malectin PF117211 -0.19 zf-TRM13_CCCH PF117222 -100.00 AvrE PF117250 100.00 DUF3296 PF117260 100.00 ISG65-75 PF117271 -0.19 DUF939_C PF117280 100.00 Cdd1 PF117312 -0.19 Thoc2 PF117320 100.00 NP1-WLL PF117330 100.00 TilS_C PF117340 100.00 DUF3300 PF117371 0.51 DUF3298 PF117380 100.00 DctA-YdbH PF117393 -100.00 KfrA_N PF117400 100.00 AMIN PF117410 100.00 DUF3302 PF117423 -0.59 ALMT PF117440 100.00 DUF3303 PF117462 -100.00 DUF3306 PF117481 -100.00 DUF3311 PF117550 100.00 YgbA_NO PF117560 100.00 RSS_P20 PF117573 -100.00 KRTAP PF117590 100.00 CbiG_N PF117602 -100.00 CbiG_mid PF117610 100.00 Arabinose_Iso_C PF117620 100.00 DIPSY PF117631 0.51 N-SET PF117640 100.00 Hyphal_reg_CWP PF117650 100.00 SET_assoc PF11767

17 -0.62 DUF3312 PF117681 -0.19 DUF3313 PF117691 -100.00 GAPT PF117700 100.00 EpuA PF117720 100.00 PulG PF117731 -100.00 Lsr2 PF11774

Sheet1

0 100.00 CobT_C PF117751 -100.00 DUF3315 PF117761 -0.19 DUF3316 PF117771 -0.19 SID PF117781 0.51 DUF3317 PF117790 100.00 DUF3318 PF117806 0.10 RRN7 PF117811 -100.00 DUF3320 PF117842 -0.88 MRP-L46 PF11788

28 -0.69 zf-Nse PF117891 -0.19 Glyco_hydro_cc PF117900 100.00 Aconitase_B_N PF117911 0.51 Baculo_LEF5_C PF11792

20 -0.54 FANCL_C PF117932 -0.19 HpaB_N PF117940 100.00 DUF3322 PF117951 -0.19 DUF3323 PF117960 100.00 DUF3324 PF117974 0.04 IMS_HHH PF117983 -0.19 IMS_C PF117992 0.73 RP-C_C PF118006 -0.37 Tom37_C PF118012 0.51 CENP-K PF118021 -100.00 UXS1_N PF118031 -100.00 DUF3325 PF118040 100.00 DUF3326 PF118050 100.00 DUF3327 PF118063 -0.19 DUF3328 PF118076 -100.00 DUF3329 PF118080 100.00 DUF3332 PF118101 -100.00 DUF3331 PF118110 100.00 DUF3333 PF118121 -100.00 DUF3335 PF118141 -100.00 DUF3336 PF118155 -1.10 DUF3337 PF118165 -1.10 Foie-gras_1 PF118170 100.00 DUF3340 PF118182 -0.88 DUF3338 PF118192 -100.00 DUF3341 PF118214 -0.19 DUF3342 PF118221 -100.00 DUF3343 PF118232 -0.88 DUF3344 PF118240 100.00 DUF3345 PF118251 -0.19 DUF3346 PF118260 100.00 DUF3347 PF118270 100.00 DUF3348 PF118287 -2.13 DUF3349 PF118291 0.51 DUF3350 PF118301 -0.19 DUF3351 PF118310 100.00 DUF3353 PF118330 100.00 DUF3354 PF118340 100.00 DUF3355 PF118350 100.00 DUF3356 PF11836

10 -1.10 DUF3357 PF118372 -100.00 DUF3358 PF118381 -100.00 DUF3359 PF118393 0.51 DUF3361 PF11841

Sheet1

0 100.00 DUF3362 PF118420 100.00 DUF3363 PF118430 100.00 DUF3364 PF118441 -100.00 DUF3365 PF118455 -0.70 DUF3366 PF118461 -0.19 DUF3367 PF118471 -0.19 DUF3368 PF118480 100.00 DUF3369 PF118490 100.00 DUF3370 PF118502 -0.88 DUF3371 PF118510 100.00 DUF3372 PF118525 -100.00 DUF3373 PF118532 -0.88 DUF3375 PF118550 100.00 DUF3376 PF118562 0.22 DUF3377 PF118572 0.22 DUF3378 PF118582 0.22 DUF3381 PF118611 -100.00 DUF3382 PF118620 100.00 DUF3383 PF118633 -0.59 DUF3384 PF118642 0.91 DUF3385 PF118651 -100.00 DUF3386 PF118660 100.00 DUF3387 PF118671 -100.00 DUF3388 PF118680 100.00 DUF3389 PF118692 -100.00 DUF3390 PF118701 -100.00 DUF3391 PF118710 100.00 DUF3392 PF118721 -0.19 DUF3394 PF118741 -0.19 DUF3395 PF118750 100.00 DUF3396 PF118760 100.00 DUF3397 PF118772 0.22 DUF3398 PF118781 0.51 DUF3399 PF118790 100.00 DUF3400 PF118801 0.51 DUF3402 PF118821 -100.00 DUF3403 PF118830 100.00 DUF3404 PF118840 100.00 DUF3407 PF118871 0.51 DUF3408 PF118880 100.00 DUF3409 PF118891 -100.00 DUF3410 PF118900 100.00 DUF3411 PF118910 100.00 DUF3412 PF118920 100.00 DUF3413 PF118932 -0.19 DUF3414 PF118940 100.00 DUF3415 PF118950 100.00 DUF3416 PF118960 100.00 DUF3417 PF118972 -100.00 DUF3418 PF118980 100.00 DUF3419 PF118992 -100.00 DUF3420 PF119009 -0.77 DUF3421 PF119010 100.00 DUF3422 PF119020 100.00 DUF3423 PF119033 -1.29 DUF3424 PF119040 100.00 DUF3427 PF11907

Sheet1

0 100.00 NdhO PF119100 100.00 DUF3429 PF119113 -100.00 DUF3432 PF119140 100.00 DUF3433 PF119153 -0.59 DUF3434 PF119160 100.00 DUF3435 PF119171 -0.19 DUF3436 PF119181 0.51 DUF3437 PF11919

14 0.47 DUF3439 PF119210 100.00 DUF3440 PF119221 -0.19 DUF3441 PF119231 -100.00 DUF3445 PF119270 100.00 DUF3446 PF119281 0.51 DUF3447 PF119292 0.22 DUF3448 PF119303 0.10 DUF3449 PF119316 0.32 DUF3450 PF119321 -0.19 DUF3451 PF119332 0.22 DUF3452 PF119343 -0.19 DUF3453 PF119352 -0.88 DUF3454 PF119361 -0.19 DUF3455 PF119374 -0.19 DUF3456 PF11938

10 -0.19 Spt5_N PF119420 100.00 DUF3460 PF119431 -100.00 DUF3461 PF119441 -0.19 DUF3462 PF119450 100.00 DUF3463 PF119463 -1.29 DUF3464 PF119471 -100.00 DUF3465 PF119481 -0.19 DUF3468 PF119511 -0.19 DUF3469 PF119521 -0.19 DUF3470 PF119531 -100.00 DUF3471 PF119541 -0.19 PORR PF119551 -100.00 KCNQC3-Ank-G_bd PF119563 -0.59 efThoc1 PF119571 -100.00 DUF3472 PF119582 -100.00 DUF3473 PF119590 100.00 DUF3474 PF119601 -100.00 DUF3475 PF119610 100.00 DUF3478 PF119641 -100.00 DUF3479 PF119650 100.00 RecO_N PF119671 -100.00 DUF3321 PF119687 -0.52 DcpS_C PF119691 -100.00 Git3_C PF11970

27 -0.39 CAMSAP_CH PF119710 100.00 MG1 PF119741 -100.00 Glyco_hydro_4C PF11975

22 -0.98 Rad60-SLD PF119763 -0.59 RNase_Zc3h12a PF119770 100.00 MVP_shoulder PF119781 1.20 DUF3480 PF119793 0.32 DUF3481 PF119801 -100.00 DUF3482 PF119812 -100.00 DUF3483 PF11982

Sheet1

5 -100.00 DUF3484 PF119831 -100.00 DUF3485 PF119841 -0.19 DUF3486 PF119852 -0.88 IF-2 PF119871 -100.00 Dsl1_C PF119890 100.00 DUF3487 PF119900 100.00 DUF3488 PF119920 100.00 Ribosomal_S4Pg PF119930 100.00 DUF3490 PF119950 100.00 DUF3491 PF119960 100.00 DUF3492 PF119971 -100.00 DUF3493 PF119981 -100.00 DUF3494 PF119991 -0.19 DUF3496 PF120011 0.51 MgsA_C PF120022 -0.19 DUF3497 PF120031 -0.19 DUF3498 PF120040 100.00 DUF3499 PF120050 100.00 DUF3500 PF120060 100.00 EcoR124_C PF120080 100.00 Telomerase_RBD PF120090 100.00 DUF3502 PF120102 -100.00 DUF3504 PF120124 0.37 DUF3505 PF120131 -100.00 DUF3506 PF120144 1.72 Transposase_37 PF120171 -0.19 DUF3508 PF120180 100.00 GspH PF120190 100.00 TAFA PF120200 100.00 DUF3509 PF120212 -0.19 DUF3510 PF120220 100.00 DUF3511 PF120231 0.51 DUF3512 PF120241 -100.00 Phage_C PF120253 -0.59 DUF3513 PF120260 100.00 DUF3514 PF120270 100.00 DUF3516 PF120292 -0.88 DUF3518 PF12031

22 -1.20 CLIP PF120320 100.00 DUF3521 PF120351 0.51 DUF3522 PF120361 -0.19 DUF3523 PF120372 -100.00 DUF3524 PF120381 0.51 DELLA PF120412 0.22 DUF3527 PF120431 0.51 Metallopep PF120441 -100.00 DUF3529 PF120460 100.00 DNMT1-RFD PF120474 -100.00 DUF3530 PF120480 100.00 DUF3532 PF120503 -1.29 DUF3533 PF120512 -0.88 VGCC_beta4Aa_N PF120522 -0.88 DUF3534 PF120531 -0.19 DUF3535 PF120540 100.00 DUF3537 PF120562 -0.19 DUF3538 PF120570 100.00 DUF3539 PF12058

Sheet1

2 -100.00 DUF3540 PF120590 100.00 DUF3541 PF120600 100.00 DUF3542 PF120611 -0.19 HSNSD PF120621 -0.19 DUF3543 PF120630 100.00 DUF3544 PF120640 100.00 DUF3545 PF120651 -0.19 DUF3546 PF120660 100.00 DUF3547 PF120675 -0.41 DUF3548 PF120681 -100.00 DUF3549 PF120691 -0.19 DUF3550 PF120703 0.10 DUF3552 PF120721 0.91 DUF3554 PF120742 -100.00 KN_motif PF120751 -0.19 Wax2_C PF120760 100.00 DUF3556 PF120772 -0.19 DUF3557 PF120780 100.00 GldM_N PF120811 -0.19 DUF3559 PF120820 100.00 DUF3560 PF120831 -100.00 DUF3562 PF120850 100.00 DUF3563 PF120862 -100.00 DUF3564 PF120870 100.00 DUF3565 PF120880 100.00 DUF3566 PF12089

10 -0.19 Spt20 PF120900 100.00 DUF3567 PF120910 100.00 DUF3568 PF120920 100.00 DUF3571 PF120950 100.00 DUF3572 PF120964 0.22 DUF3573 PF120970 100.00 DUF3574 PF120980 100.00 DUF3576 PF121000 100.00 DUF3578 PF121020 100.00 Lipl32 PF121032 -100.00 Colicin_C PF121061 0.91 SF3a60_bindingd PF121081 0.51 Nup96 PF121100 100.00 PNPase_C PF121110 100.00 DUF3579 PF121120 100.00 SVM_signal PF12113

10 -100.00 Period_C PF121140 100.00 Salp15 PF121151 1.20 SpoIIID PF121161 -100.00 DUF3580 PF12117

17 -0.82 SprA-related PF121182 -100.00 RNApol_Rpb2_rif PF121201 -100.00 DUF3582 PF121220 100.00 Amidase02_C PF121231 -100.00 Nsp3_PL2pro PF121241 0.51 Beta-TrCP_D PF121250 100.00 DUF3583 PF12126

10 0.34 DUF3584 PF121284 -1.57 Phtf-FEM1B_bdg PF121293 0.10 DUF3585 PF121300 100.00 DUF3587 PF12132

Sheet1

1 -100.00 Sars6 PF121331 -0.19 PRP8_domainIV PF121340 100.00 RNA_pol_Rpo13 PF121360 100.00 RapA_C PF121371 -100.00 Spherulin4 PF121381 0.51 DUF3588 PF121401 -100.00 PPO1_DWL PF121420 100.00 Med12-PQL PF121441 -0.19 Med12-LCEWAV PF12145

17 -0.54 Hydrolase_4 PF121461 -100.00 Hydrolase_5 PF121470 100.00 DUF3590 PF121480 100.00 MVL PF121510 100.00 eIF_4G1 PF121524 -0.88 CAP18_C PF121531 0.51 HCMVantigenic_N PF121540 100.00 NADHdh-2_N PF121550 100.00 ATPase-cat_bd PF121561 0.51 DUF3591 PF121572 -100.00 DUF3592 PF121581 -100.00 DUF3593 PF121591 -100.00 Fibrinogen_aC PF121600 100.00 HsdM_N PF121610 100.00 HobA PF121631 -0.19 SporV_AA PF121642 0.91 DUF3595 PF121660 100.00 DUF3596 PF121672 -100.00 DNA_pol3_tau_4 PF12168

234 -0.43 zf-C2H2_jaz PF121718 -1.17 DUF35_N PF121720 100.00 BacteriocIIc_cy PF121730 100.00 RST PF121740 100.00 WSS_VP PF121750 100.00 MtaB PF121760 100.00 Proho_convert PF121772 -100.00 INCENP_N PF121781 0.51 IKKbetaNEMObind PF121791 -100.00 EABR PF121800 100.00 MogR_DNAbind PF121810 100.00 DUF3642 PF121820 100.00 DN_homeodomain PF121840 100.00 IR1-M PF121851 -0.19 AcylCoA_dehyd_C PF121860 100.00 VirArc_Nuclease PF121870 100.00 amfpi-1 PF121907 -1.44 stn_TNFRSF12A PF121910 100.00 CBP PF121920 100.00 Ste5_C PF121941 0.51 hNIFK_binding PF121960 100.00 Tuberculin PF121980 100.00 efb-c PF121992 -100.00 DUF3597 PF122003 -0.59 OSR1_C PF122021 -100.00 HDAC4_Gln PF122030 100.00 DUF3598 PF122042 -0.19 GIT1_C PF122050 100.00 SAC3 PF12209

Sheet1

2 -0.88 Hrs_helical PF122100 100.00 PAZ_siRNAbind PF122124 -0.88 Dpoe2NT PF122130 100.00 TPX2_importin PF122141 -100.00 GBA2_N PF122151 -100.00 m04gp34like PF122160 100.00 End_beta_propel PF122171 -100.00 End_N_terminal PF122181 -100.00 End_tail_spike PF122193 -1.29 U1snRNP70_N PF122200 100.00 HflK_N PF122210 100.00 PNGaseA PF122220 100.00 DUF3602 PF122233 -100.00 Amidoligase_2 PF122240 100.00 MTHFR_C PF122251 -100.00 DUF3604 PF122280 100.00 PG_binding_4 PF122294 0.22 PRP21_like_P PF122302 -0.19 Rif1_N PF122311 -100.00 Myf5 PF122322 -0.19 Rav1p_C PF122340 100.00 FXR1P_C PF122350 100.00 Head-tail_con PF122361 1.20 PCIF1_WW PF122372 -0.88 MSA-2c PF122380 100.00 DUF3605 PF122391 -0.19 Angiomotin_C PF12240

15 -0.82 Eno-Rase_NADH_b PF122424 -0.19 CTK3 PF122430 100.00 DUF3606 PF122440 100.00 DUF3607 PF122451 -100.00 MKT1_C PF122460 100.00 MKT1_N PF122472 -0.19 Methyltransf_FA PF122480 100.00 AftA_C PF122491 0.51 zf-SNAP50_C PF122512 -0.88 CAF1A PF122532 0.22 DNA_pol_alpha_N PF122540 100.00 TcdB_toxin_midC PF122552 -100.00 TcdB_toxin_midN PF122561 0.91 DUF3608 PF122571 0.91 DUF3609 PF122591 -0.19 PIP49_C PF122600 100.00 Lipase_bact_N PF122621 -0.19 DUF3611 PF122630 100.00 Peptidase_C03 PF122642 0.22 CAF1C_H4-bd PF122650 100.00 DUF3613 PF122661 -100.00 DUF3614 PF122674 0.04 zf-CpG_bind_C PF122691 -0.19 Cyt_c_ox_IV PF122700 100.00 Chs3p PF122712 -0.19 DUF3610 PF122724 -0.88 RCR PF122731 -100.00 DUF3616 PF122751 -0.19 DUF3617 PF122761 -100.00 DUF3618 PF12277

Sheet1

0 100.00 SDP_N PF122780 100.00 DUF3619 PF122792 -0.19 BSMAP PF122800 100.00 H_kinase_N PF122821 -100.00 Protein_K PF122831 -100.00 HoxA13_N PF122840 100.00 DUF3621 PF122850 100.00 Caprin-1_C PF122870 100.00 Rotavirus_VP1 PF122890 100.00 Topoisom_IIA_B PF122900 100.00 DUF3624 PF122921 0.91 Symplekin_C PF122950 100.00 HsbA PF122961 0.91 EVC2_like PF122970 100.00 DUF3627 PF122991 0.51 DUF3628 PF123004 -1.57 CD99L2 PF123011 -100.00 DUF3629 PF123020 100.00 SNDH PF123030 100.00 BCLP PF123040 100.00 DUF3630 PF123050 100.00 PixA PF123060 100.00 DUF3631 PF123073 -1.29 Noelin-1 PF123083 -0.19 KBP_C PF123090 100.00 Elf-1_N PF123101 -0.19 NeA_P2 PF123121 -100.00 NPR1_like_C PF123133 -100.00 IMCp PF123140 100.00 DUF3633 PF123151 1.20 Dsh_C PF123162 -0.88 IFT46_B_C PF123170 100.00 FAD-SLDH PF123180 100.00 TryThrA_C PF123190 100.00 SbcD_C PF123201 -100.00 DUF3634 PF123210 100.00 T4_baseplate PF123220 100.00 HTH_14 PF123231 -100.00 HTH_15 PF12324

14 0.17 TMF_TATA_bd PF123251 -100.00 FtsZ_C PF123271 -0.19 Rpp20 PF12328

23 0.14 TMF_DNA_bd PF123291 -100.00 DUF3635 PF123300 100.00 DUF3636 PF123311 -100.00 McpA_N PF123326 0.10 Ipi1_N PF123332 -0.19 SBF2 PF123352 -0.19 SOXp PF123360 100.00 DUF3637 PF123370 100.00 DUF3638 PF123402 0.22 DUF3639 PF123410 100.00 UvrB PF123440 100.00 DUF3641 PF123450 100.00 HJURP_mid PF123462 -0.19 HJURP_C PF12347

15 0.20 CLASP_N PF12348

Sheet1

7 0.35 Sterol-sensing PF123491 -100.00 CTK3_C PF123501 0.51 Fig1 PF123519 -0.77 V-SNARE_C PF123523 0.32 eIF3g PF123531 -0.19 Internalin_N PF123541 -100.00 Dscam_C PF123551 -0.19 DUF3643 PF123561 -100.00 PLD_C PF123570 100.00 DUF3644 PF123581 -100.00 Pax7 PF123601 -100.00 DUF3646 PF123620 100.00 DUF3647 PF123636 -1.29 Casc1 PF123660 100.00 PFO_beta_C PF123673 -100.00 DUF3650 PF123680 100.00 GnHR_trans PF123690 100.00 CoABC_C PF123701 -100.00 DUF3651 PF123711 -0.19 DUF3652 PF123721 -0.19 Dmrt1 PF123741 -100.00 DUF3653 PF123751 -100.00 DUF3654 PF123760 100.00 DUF3655 PF123790 100.00 Peptidase_C62 PF123800 100.00 Peptidase_C3G PF123811 -100.00 Peptidase_A2E PF123820 100.00 SARS_3b PF123830 100.00 Peptidase_A2B PF123841 -100.00 Peptidase_C70 PF123850 100.00 Peptidase_C71 PF123860 100.00 Peptidase_C74 PF123874 -0.47 Peptidase_M57 PF123880 100.00 Peptidase_M73 PF123891 -100.00 Se-cys_synth_N PF123900 100.00 PCDO_beta_N PF123911 -100.00 DUF3656 PF123921 -0.19 DUF3657 PF123941 -100.00 DUF3658 PF123951 -100.00 DUF3659 PF123962 -0.88 U3snoRNP10 PF123971 -100.00 DUF3660 PF123981 -100.00 BCA_ABC_TP_C PF123991 -100.00 DUF3661 PF124000 100.00 DUF3662 PF124011 -100.00 DUF3664 PF124061 0.51 Abdominal-A PF124070 100.00 DUF3666 PF124084 -0.47 P_ATPase PF124090 100.00 rpo30_N PF124100 100.00 DUF3667 PF124120 100.00 rpo132 PF124151 0.51 DUF3668 PF124161 -100.00 DUF3669 PF124170 100.00 AcylCoA_DH_N PF124180 100.00 DUF3670 PF124197 -0.75 DUF3671 PF12420

Sheet1

1 1.20 Condensin2nSMC PF124223 -0.59 KIF1B PF124232 0.51 ATP_Ca_trans_C PF124240 100.00 DUF3673 PF124250 100.00 DUF3674 PF124261 -0.19 DUF3665 PF124270 100.00 DUF3675 PF124280 100.00 DUF3676 PF124292 -0.88 ABA_GPCR PF124302 -100.00 DUF3677 PF124320 100.00 PV_NSP1 PF124330 100.00 Malate_DH PF124340 100.00 DUF3678 PF124351 0.51 USP7 PF124360 100.00 GSIII_N PF124370 100.00 GDE_N PF124390 100.00 MAGE_N PF124400 100.00 DUF3680 PF124411 -0.19 DUF3681 PF124423 0.10 AKNA PF124431 1.20 Sox_N PF124440 100.00 FliC PF124453 -1.29 DUF3682 PF124460 100.00 DUF3683 PF124471 -0.19 Milton PF124480 100.00 vWF_A PF124500 100.00 VPS11_C PF124510 100.00 DUF3685 PF124520 100.00 PTP_N PF124530 100.00 Ecm33 PF124542 -0.19 Dynactin PF124552 -0.19 hSac2 PF124561 -0.19 TIP_N PF124570 100.00 DUF3687 PF124592 0.51 MMS19_N PF124601 -100.00 DUF3688 PF124610 100.00 Nucleolin_N PF124621 -100.00 DUF3689 PF124631 -100.00 Mac PF124642 -0.88 Pr_beta_C PF124650 100.00 GDH_N PF124660 100.00 CMV_1a PF124671 -100.00 TTSSLRR PF124681 -0.19 DUF3692 PF124691 -0.19 SUFU_C PF124701 -0.19 DUF3693 PF124723 -0.59 DUF3694 PF124731 -100.00 PKK PF124740 100.00 Amdo_NSP PF124750 100.00 DUF3696 PF124760 100.00 TraW_N PF124771 -100.00 DUF3697 PF124780 100.00 DUF3698 PF124791 -100.00 DUF3699 PF124801 -100.00 DUF3700 PF124810 100.00 DUF3701 PF124821 -0.19 GIDE PF12483

Sheet1

1 -100.00 SLY PF124851 -0.19 DUF3702 PF124860 100.00 DUF3704 PF124884 -100.00 ARA70 PF124892 -0.88 BCAS3 PF124900 100.00 DUF3705 PF124920 100.00 DUF3709 PF124931 -0.19 DUF3695 PF124941 -100.00 Vip3A_N PF124952 -0.88 BNIP2 PF124961 -100.00 bZIP_C PF124983 -100.00 DUF3708 PF125010 100.00 DUF3710 PF125020 100.00 CMV_1a_C PF125030 100.00 DUF3711 PF125040 100.00 DUF3712 PF125050 100.00 DUF3713 PF125060 100.00 HCMV_UL139 PF125070 100.00 DUF3714 PF125080 100.00 DUF3715 PF125093 -100.00 Smoothelin PF125103 -1.29 DUF3716 PF125110 100.00 DUF3717 PF125121 0.51 SUV3_C PF125131 -0.19 DUF3718 PF125140 100.00 DUF3719 PF125161 -100.00 DUF3720 PF125170 100.00 DUF3721 PF125180 100.00 DUF3724 PF125211 -0.19 UL73_N PF125222 -100.00 DUF3725 PF125230 100.00 GlyL_C PF125240 100.00 DUF3726 PF125251 -100.00 DUF3729 PF125260 100.00 DUF3727 PF125271 -0.19 Xylo_C PF125291 1.20 DUF3730 PF125300 100.00 DUF3731 PF125310 100.00 Neuro_bHLH PF125331 -0.19 DUF3733 PF125341 -100.00 DUF3734 PF125362 -0.19 DUF3735 PF125371 -0.19 FtsK_SpoIIIE_N PF125382 -0.88 DUF3736 PF125401 -100.00 DUF3737 PF125411 0.91 CWC25 PF125420 100.00 DUF3738 PF125430 100.00 LAM_C PF125440 100.00 Cryptochrome_C PF125460 100.00 ATXN-1_C PF125471 0.51 DUF3740 PF125480 100.00 TOH_N PF125490 100.00 GCR1_C PF125500 100.00 PHBC_N PF125510 100.00 DUF3741 PF125521 -100.00 DUF3742 PF125530 100.00 DUF3743 PF12554

Sheet1

2 -0.88 TPPK_C PF125550 100.00 Co_AT_N PF125571 -0.19 DUF3744 PF125581 -0.19 Inhibitor_I10 PF125590 100.00 DUF3746 PF125621 0.51 TypeIII_RM_meth PF125640 100.00 DUF3747 PF125650 100.00 DUF3748 PF125660 100.00 CD45 PF125671 -100.00 DUF3749 PF125681 -0.19 NARP1 PF125691 -0.19 DUF3752 PF125720 100.00 OxoDH_E1alpha_N PF125730 100.00 120_Rick_ant PF125743 -100.00 DUF3753 PF125752 -0.88 DUF3754 PF125760 100.00 PPARgamma_N PF125772 -100.00 3-PAP PF125781 -100.00 DUF3755 PF125791 -0.19 TPPII PF125802 0.51 TPPII_N PF125830 100.00 DUF3758 PF125842 -100.00 DUF3761 PF125872 -100.00 PSDC PF125881 -0.19 WBS_methylT PF125890 100.00 Acyl-thio_N PF125900 100.00 DUF3762 PF125910 100.00 DUF3763 PF125921 -100.00 DUF3764 PF125941 -100.00 Rhomboid_SP PF125950 100.00 87kDa_TransP PF125961 0.51 DUF3767 PF125970 100.00 TBX PF125980 100.00 DUF3769 PF126000 100.00 DUF3770 PF126031 -100.00 CK1gamma_C PF126050 100.00 RELT PF126061 -0.19 DUF3772 PF126070 100.00 DUF3774 PF126092 -100.00 SOCS PF126103 0.51 TFCD_C PF126122 -0.88 RRF_GI PF126140 100.00 TraD_N PF126152 -100.00 DUF3775 PF126160 100.00 LdpA_C PF126172 -0.19 MCM2_N PF126191 -100.00 DUF3778 PF12620

Sheet1

Pfam description

EM----V 7 transmembrane receptor (rhodopsin family)EM----- 7 transmembrane receptor (Secretin family)EM----- 7 transmembrane sweet-taste receptor of 3 GCPREMFPBAV ATPase family associated with various cellular activities (AAA)EMFPBAV ABC transporterEMFPBA- ATP synthase alpha/beta family, nucleotide-binding domainEM----- Cystine-knot domainEM----V EGF-like domainEMFPBAV Elongation factor Tu GTP binding domainEMFP--V Helix-loop-helix DNA-binding domainEMFPBA- Hsp20/alpha crystallin familyEMFPBAV Hsp70 proteinEMFPBA- KH domainEM----- Kunitz/Bovine pancreatic trypsin inhibitor domain----BA- Methyl-accepting chemotaxis protein (MCP) signaling domainE--PBA- Ribulose bisphosphate carboxylase large chain, catalytic domainEMF---V SH2 domainEMF---V SH3 domainEM----- Transforming growth factor beta like domainEM-P--V TNFR/NGFR cysteine-rich regionEM----V u-PAR/Ly-6 domainEMFP--V ActinEMFPBAV Ankyrin repeatEM-P--V PAN domainEMFPB-- ADP-ribosylation factor familyEMFP--- Eukaryotic aspartyl proteaseEMFPB-- Cyclic nucleotide-binding domainEM----- Cadherin domainEM----- ConnexinEM--B-- Beta/Gamma crystallinEM-P--- Cystatin domainEMFPB-- Cytochrome b(C-terminal)/b6/petDEMFPB-- Cytochrome b(N-terminal)/b6/petBEMFPB-- Cytochrome cEMFPB-V Double-stranded RNA binding motifEMFPB-- EF handEMFPBA- 4Fe-4S binding domainEM----- Intermediate filament proteinEM----- Fibronectin type II domainEM-PBA- Fibronectin type III domainEMFPB-- GlobinEMFPB-- Glutathione S-transferase, C-terminal domainEMFPBA- Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain

Species distribution

Sheet1

EM-P--V HemopexinEMFP--V Homeobox domainEM----V Immunoglobulin domainEM----- Insulin/IGF/Relaxin familyEM----- Kazal-type serine protease inhibitor domainEM----- Kringle domainEM----- Laminin B (Domain IV)EM----- Laminin EGF-like (Domains III and V)EM----- Laminin G domainEM----- Laminin N-terminal (Domain VI)EMFPBA- lactate/malate dehydrogenase, NAD binding domainEM----- Low-density lipoprotein receptor domain class AEM----- Low-density lipoprotein receptor repeat class BEM----V Lectin C-type domainEM-P--- Ligand-gated ion channelEM----- Lipocalin / cytosolic fatty-acid binding protein familyEM----- C-type lysozyme/alpha-lactalbumin familyEMF---- Myosin head (motor domain)------V NeuraminidaseEM----- LNR domainEMFPBAV Cytochrome P450EM----- Phospholipase A2EMFPBAV Protein kinase domainEMFPBA- Pyridine nucleotide-disulphide oxidoreductaseEMFP--V Ras familyEMFPBA- Response regulator receiver domainEM----- Pancreatic ribonucleaseEMFPB-V RNase HEMFPB-- RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)EM-PB-V Retroviral aspartyl proteaseEMFPB-V Reverse transcriptase (RNA-dependent DNA polymerase)EM-P-AV Serpin (serine protease inhibitor)EMFPB-V Copper/zinc superoxide dismutase (SODC)EMFPBA- Iron/manganese superoxide dismutases, alpha-hairpin domainEMFPBA- Subtilase familyEMFPB-- Sugar (and other) transporterEM----V Sushi domain (SCR repeat)EMFPB-V ThioredoxinEM----- Thyroglobulin type-1 repeatEM----- Snake toxinEM----- Trefoil (P-type) domainEMFPB-- TrypsinEM----- Thrombospondin type 1 domainEMFPBA- Tubulin/FtsZ family, GTPase domainEM-PB-V von Willebrand factor type A domainEM----- von Willebrand factor type C domainEM----- von Willebrand factor type D domainEM----- WAP-type (Whey Acidic Protein) 'four-disulfide core'EMFP--V Zinc finger, C2H2 typeEMFP--V Zinc finger, C3HC4 type (RING finger)EMFP--V Zinc knuckleEM----- Zona pellucida-like domainEMF-B-- Protein-tyrosine phosphataseEM----- Somatotropin hormone familyEM----V Ligand-binding domain of nuclear hormone receptorEM----V Zinc finger, C4 type (two domains)EMFPB-V short chain dehydrogenase

Sheet1

EMFPBAV Zinc-binding dehydrogenaseEMFPBA- Thiolase, N-terminal domainEMFPB-- Beta-ketoacyl synthase, N-terminal domainEM----- wnt familyEMFPBA- 2Fe-2S iron-sulfur cluster binding domainEM-P--V Papain family cysteine proteaseEMFPBA- Enolase, C-terminal TIM barrel domain----B-- Pilin (bacterial filament)EMFPBA- Cytochrome C and Quinol oxidase polypeptide IEMFPBA- Cytochrome C oxidase subunit II, periplasmic domainEMFPBAV Glutamine amidotransferase class-IEMFPBA- TCP-1/cpn60 chaperonin familyEMFPB-- ATP synthase A chainEMFPBAV Glutamine synthetase, catalytic domainEMFPBA- Triosephosphate isomeraseEMFPBA- E1-E2 ATPaseEM----- Peptide hormoneEMFP--- Core histone H2A/H2B/H3/H4E--PBA- Bacterial regulatory helix-turn-helix protein, lysR familyEMFPBA- Alpha amylase, catalytic domainEM----V Class I Histocompatibility antigen, domains alpha 1 and 2EMFP--- Phorbol esters/diacylglycerol binding domain (C1 domain)EM----- MetallothioneinEMFPBA- Bacterial transferase hexapeptide (three repeats)EMFPBA- tRNA synthetases class I (I, L, M and V)EMFP--V Cyclin, N-terminal domainEMF-B-V CarboxylesteraseEMFPBAV DNA polymerase family BEMFPBA- ATP synthase subunit CE--P-A- Legume lectin domain----B-- Sigma-70 factor, region 1.2EMFPBA- PeroxidaseE--PBA- 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC familyEM----- Interferon alpha/beta domainEMFPBAV C-5 cytosine-specific DNA methylaseEMFPBA- NADH dehydrogenaseEM----- Fibrinogen beta and gamma chains, C-terminal globular domainE--PBA- Nitrogenase component 1 type OxidoreductaseEMFPBAV Calcineurin-like phosphoesteraseEMFPB-- Cellulase (glycosyl hydrolase family 5)EM----- LipaseEMFPBA- tRNA synthetases class II (D, K and N) EMFP--V Mitochondrial carrier proteinE-FPB-V recA bacterial DNA recombination proteinEMFPBA- Aminotransferase class I and IIEMFPBA- Phosphoribosyl transferase domainEM----- Pou domain - N-terminal to homeobox domain----BA- Sigma-54 interaction domainEM----- Pancreatic hormone peptideEMFPB-V Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLDE--PB-V Ribosome inactivating proteinEMFPBA- Phosphoglycerate kinaseEMFPBA- Ribosomal protein S4/S9 N-terminal domainEMFPBA- Ribosomal protein S12----B-- Bacterial regulatory helix-turn-helix proteins, AraC familyEMFPBAV Chaperonin 10 Kd subunitEM----V Fibroblast growth factor

Sheet1

EMFP--- C2 domainEMFP--V PH domainEMFP--V bZIP transcription factorEMFPBA- Aldehyde dehydrogenase familyEMFPB-V Cytochrome b5-like Heme/Steroid binding domainEMFPB-- Oxidoreductase molybdopterin binding domainEMFPBA- Oxidoreductase NAD-binding domain EMFPB-V SNF2 family N-terminal domainEMFPBA- Ribosomal protein S7p/S5eEM----V Ets-domainEMFP--V Ubiquitin-conjugating enzymeEMFPBA- Isocitrate/isopropylmalate dehydrogenaseEMFPBA- Ribosomal Proteins L2, RNA binding domainE--PB-- Chitinase class IEMFPB-- Hsp90 proteinEM----- Neurohypophysial hormones, C-terminal DomainEMFPBA- Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domainEMFPBAV Dihydrofolate reductaseE-FP--- Chitin recognition proteinEMFPB-- Cysteine-rich secretory protein familyEMFPBA- Ribosomal protein S3, C-terminal domainE--PB-- CupinEM-P--- AnnexinEM----- Extracellular link domainEM-PB-V Eukaryotic-type carbonic anhydraseE--PB-- Chalcone and stilbene synthases, N-terminal domainE---B-- Bacterial regulatory proteins, luxR familyEMFPB-- 2-oxoacid dehydrogenases acyltransferase (catalytic domain)EMFPBA- CatalaseEMF---- DisintegrinEMFPB-V UDP-glucoronosyl and UDP-glucosyl transferaseEMFPBA- Aminotransferase class-IIIEMFPBA- Ribosomal protein S19EMFPBAV DNA gyrase BEMFPBA- Thiamine pyrophosphate enzyme, central domainEMFPBA- LyaseEM--B-- Alpha-2-macroglobulin familyEMFPBA- Glutamate/Leucine/Phenylalanine/Valine dehydrogenaseEM--BA- Sodium:neurotransmitter symporter familyEM-PBA- Ferritin-like domainEMF-B-V Adenylate and Guanylate cyclase catalytic domainEMFPB-- ATP synthase delta (OSCP) subunitEM----- Calcitonin / CGRP / IAPP familyEMFPBA- Orotidine 5'-phosphate decarboxylase / HUMPS familyE---BAV Bacterial DNA-binding proteinEM--B-- ATP:guanido phosphotransferase, C-terminal catalytic domainEM----- Insulin-like growth factor binding proteinEM----- Neurohypophysial hormones, N-terminal DomainEMFPBA- Pyruvate kinase, barrel domainEMFP--- Kinesin motor domainEMFPBAV DnaJ domainEMFPBA- Proteasome subunitEM----- TNF(Tumour Necrosis Factor) family EMFPBA- Major intrinsic proteinEMFPB-- ATP synthaseEM-PBA- Glycosyl hydrolase family 1EMF---- 3'5'-cyclic nucleotide phosphodiesterase

Sheet1

E--P--- Protease inhibitor/seed storage/LTP familyEMFP--V ProfilinEM----- Glycoprotein hormoneEMFPBA- Ribosomal protein L22p/L17eEMFPBA- Ribosomal protein L14p/L23e----BAV Resolvase, N terminal domainEMFP--V Ubiquitin familyEMFP--- Cofilin/tropomyosin-type actin-binding protein------V DNA polymerase (viral) N-terminal domainEM----- Nerve growth factor family

EMF-B-- Alkaline phosphataseEMF-B-- Zinc carboxypeptidaseEMFPB-- Aldo/keto reductase familyEMFP--V Myb-like DNA-binding domainEMF---V Fork head domainE-FPB-- Glycosyl hydrolases family 32 N-terminal domainEMFPBA- Ribosomal protein L16p/L10eEMFPBA- Ribosomal protein S14p/S29eEMFPBA- FKBP-type peptidyl-prolyl cis-trans isomeraseEMFPB-V Glutathione peroxidaseE--P--- DehydrinEMFPBA- FlavodoxinEM----- TropomyosinEMFP--- Calreticulin family----B-V Bacterial type II and III secretion system proteinEMFPB-- Common central domain of tyrosinaseEMFPBAV Thymidine kinaseEMFPBAV Aminotransferase class-VEMFPB-V Ribonucleotide reductase, small chain----B-- Small, acid-soluble spore proteins, alpha/beta typeEMFPBAV DEAD/DEAH box helicaseEMFPBAV Helicase conserved C-terminal domainEM----- Cecropin familyEM----- Serum albumin familyEM-PB-- Fructose-bisphosphate aldolase class-IEMFPBA- Ribosomal protein L23EM----- Serum amyloid A proteinEMFPBA- Pyridoxal-dependent decarboxylase, C-terminal sheet domainEMFPBA- Ribosomal protein L5EMFPBA- Pyridoxal-dependent decarboxylase conserved domainE--PB-- Lumenal portion of Cytochrome b559, alpha (gene psbE) subunitEMFPBA- Citrate synthase------V Viral coat proteinEM----- Sodium / potassium ATPase beta chainEMFPBA- GHMP kinases N terminal domainEMFPBA- Carbamoyl-phosphate synthase L chain, N-terminal domainE-FPBA- Tryptophan synthase alpha chainEMFPBA- Pyridoxal-phosphate dependent enzymeEM----- Paired box' domainEMFPBAV NUDIX domainEMFPBA- pfkB family carbohydrate kinase----BA- Luciferase-like monooxygenaseEMFPBA- Ribosomal protein L3EMFPBA- Ribosomal protein L11, RNA binding domainEM-P--- Squash family serine protease inhibitorEMF-BAV Phosphoglycerate mutase family

Sheet1

----BA- Rubredoxin----B-- Chloramphenicol acetyltransferaseEMFPBAV Thymidylate synthaseEM-P--- Gamma-thionin familyEMFPBA- ATP synthase alpha/beta chain, C terminal domainEMFP--- Calponin homology (CH) domain----BA- Bacterial dnaA protein----B-- Sigma-54 factor, Activator interacting domain (AID) EMFPBAV Glutamine amidotransferases class-IIEMFPBA- Ribosomal protein S15EM-PB-- Cold-shock' DNA-binding domainEMFPBA- Fructose-1-6-bisphosphataseEMFPB-V Ribonucleotide reductase, all-alpha domainEMFPBA- Ribosomal protein S2EMFP--- SRF-type transcription factor (DNA-binding and dimerisation domain)EMFP--- GATA zinc fingerE--P--- Plant thioninEM----- Endothelin familyEM----- Mammalian defensinEMF-BA- Amino acid permease----B-- Bacterial regulatory proteins, crp familyEMF-BAV Prolyl oligopeptidase familyEMFPBA- Ribosomal protein L30p/L7eEMF-B-- Histidine acid phosphataseEMFPB-- Respiratory-chain NADH dehydrogenase, 30 Kd subunitEMFPBA- Aconitase family (aconitate hydratase)E-FP--- Glycosyl hydrolases family 17EMFPBA- Ribosomal protein S5, N-terminal domainEMFPBAV Nucleoside diphosphate kinaseEM----- Tetraspanin family------V DNA polymerase (viral) C-terminal domainEMFP--- Galactoside-binding lectinEMFPBA- Ribosomal protein S10p/S20eEMF---- Arrestin (or S-antigen), N-terminal domainEM----- Interleukin-1 / 18EM----V Platelet-derived growth factor (PDGF)EMFPBA- Phosphoglucose isomeraseEMFPBA- Carbohydrate phosphorylaseEMFPBA- eubacterial secY proteinEMFPBA- Respiratory-chain NADH dehydrogenase, 49 Kd subunitEMFPBA- Ribosomal protein L6EMFPBAV Polyprenyl synthetaseEMFP--- HexokinaseEMFPB-V Dynamin familyEM--B-- Biopterin-dependent aromatic amino acid hydroxylaseEMFP-AV Transcription factor TFIID (or TATA-binding protein, TBP)EM----- Pentaxin familyEMFPBA- Rieske [2Fe-2S] domain----B-- Bacterial regulatory proteins, lacI familyEM----- Integrin alpha cytoplasmic region----B-- phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1EM--B-- Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2EMFPBA- NADH-Ubiquinone/plastoquinone (complex I), various chainsEM----- Integrin, beta chainEM----- CaseinEMFPBA- Biotin-requiring enzymeEMFPB-- Phosphofructokinase

Sheet1

EMFPBA- Ribosomal protein S17----B-- phosphotransferase system, EIIBEMFPBA- Hydroxymethylglutaryl-coenzyme A reductaseEMF-BA- FGGY family of carbohydrate kinases, N-terminal domainEM----- Hemocyanin, copper containing domainEM----- FERM central domain----BA- Nickel-dependent hydrogenaseEM--B-- Sodium:dicarboxylate symporter family----BA- MerR family regulatory proteinEM----- Prion/Doppel alpha-helical domainEMFPB-- Enoyl-CoA hydratase/isomerase familyEM----- Insect cuticle proteinEMFPBA- Ribosomal protein S9/S16----B-- PTS HPr component phosphorylation siteEMFP-AV Transcription factor TFIIB repeatEMFPB-V Cytidine and deoxycytidylate deaminase zinc-binding regionEMFPBA- Molybdopterin oxidoreductaseEMFP--- chromo' (CHRromatin Organisation MOdifier) domainEM--B-- C1q domainEMFP--- Phosphatidylinositol-specific phospholipase C, Y domainEMFPB-- Phosphatidylinositol-specific phospholipase C, X domainEMFPBA- D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domainEMFPB-- Malic enzyme, N-terminal domainE--PBA- PEP-utilising enzyme, mobile domain----B-- Bacterial regulatory proteins, gntR familyEMF-B-- 6-phosphogluconate dehydrogenase, C-terminal domainEMFPB-- Multicopper oxidaseEM-P--- GranulinEMFP--- WW domainEMF-BA- Ribosomal RNA adenine dimethylaseEMFPB-V WD domain, G-beta repeatE--PB-- ATP synthase, Delta/Epsilon chain, long alpha-helix domainEM----- Calponin family repeatEMFPBA- Heavy-metal-associated domain----B-- Dockerin type I repeatEM----- TransferrinEMFPBA- Adenylate kinaseEMFPBA- Phosphoglucomutase/phosphomannomutase, C-terminal domainEMFPBA- Ribosomal protein S8EMFPBA- Ribosomal protein S11EMFP--- LIM domainEM-PB-V MatrixinEMF---- Regulator of chromosome condensation (RCC1) repeatEMFPBA- Ribosomal protein S13/S18E--PB-- Ribosomal protein S3, N-terminal domainEM----- Tau and MAP protein, tubulin-binding repeat----B-- Fimbrial proteinEMFPBA- NADH-ubiquinone/plastoquinone oxidoreductase chain 4LE--PB-- Photosystem II protein------V REV protein (anti-repression trans-activator protein)------V Outer Capsid protein VP4 (Hemagglutinin)E---B-- Phycobilisome Linker polypeptideEMFP-A- 60s Acidic ribosomal proteinEM----V ENV polyprotein (coat polyprotein)E--PBA- ATP synthase B/B' CF(0)EM----- CUB domainEMFPB-- Prenyltransferase and squalene oxidase repeat

Sheet1

EMFP--V Protein kinase C terminal domainEM----- Spectrin repeatEMFPB-V Single-strand binding protein family----BA- Type II/IV secretion system proteinEMFPB-- S-adenosylmethionine synthetase, N-terminal domainEMFP--- Bromodomain----B-- Bacterial regulatory proteins, tetR familyEMFPB-- Acyl-CoA dehydrogenase, C-terminal domainEMFP--V Ubiquitin carboxyl-terminal hydrolaseEMFPB-- Ribosomal protein L36EMFPB-- Ribonuclease T2 familyEMFP--- HSF-type DNA-bindingEMFPBA- SRP54-type protein, GTPase domainE-FPBA- Urease alpha-subunit, N-terminal domainEMFP--- Serine carboxypeptidaseEM----- Scorpion short toxinEM----V Apoptosis regulator proteins, Bcl-2 familyEM-PB-- Ribosomal protein L20EMFP--V Phosphatidylinositol 3- and 4-kinase----BA- Bacterial regulatory proteins, deoR familyEMFPBA- Transketolase, thiamine diphosphate binding domainEMF-B-- Glycosyl hydrolases family 11EMFP--- WHEP-TRS domainEMFPBA- Inositol monophosphatase family----B-- Flagella basal body rod proteinEMFPBAV GlutaredoxinEMFPBA- Serine hydroxymethyltransferaseEMF-B-- Iron-containing alcohol dehydrogenase EMFPBA- Ribosomal protein L10EMFPBA- KOW motifEMFPB-- Ribosomal protein L34------V Negative factor, (F-Protein) or NefEMFPB-- Ribosomal protein L33EMF-B-- RF-1 domainEM----- Corticotropin-releasing factor familyEMF-B-- Sodium:solute symporter familyE-FPBA- Imidazoleglycerol-phosphate dehydrataseEMF-B-V DNA polymerase family AEMFPBA- IMP dehydrogenase / GMP reductase domainEMFPB-- Glucose-6-phosphate dehydrogenase, NAD binding domainEM--B-- ROK familyEMFPB-V Protein phosphatase 2C----BA- Bacterial type II secretion system protein F domainEMFPBAV Nucleotidyl transferaseEMFPB-- Carbonic anhydraseEMFPBA- Phosphoribulokinase / Uridine kinase familyE---B-- Transcriptional regulatory protein, C terminalEMFPB-- Fatty acid desaturaseEMFPBAV MutS domain VEM----- Interleukin-6/G-CSF/MGF familyEMFPBA- Delta-aminolevulinic acid dehydrataseEMFPBA- Arginase familyEMFP-A- MCM2/3/5 familyEMFPB-- Squalene/phytoene synthase----B-- Bacterial extracellular solute-binding proteins, family 5 MiddleEM-PB-- Bacterial extracellular solute-binding proteins, family 3EMFPB-- FHA domain

Sheet1

EMFPB-- NADH-ubiquinone/plastoquinone oxidoreductase chain 6------V L1 (late) proteinEMFPBA- AMP-binding enzymeEMFP--- G-protein alpha subunitEMFP--V HMG (high mobility group) box------V Influenza virus nucleoproteinEMFPB-- NADH-ubiquinone/plastoquinone oxidoreductase, chain 3------V E2 (early) protein, N terminal----B-V HemagglutininEMFPBA- Cytochrome c oxidase subunit III------V E2 (early) protein, C terminalE-FPB-- His Kinase A (phosphoacceptor) domainEMFP--- Armadillo/beta-catenin-like repeatEMFPBA- Tetratricopeptide repeat------V Envelope glycoprotein GP120EM----V Retroviral envelope protein------V Early Protein (E6)------V Papillomavirus helicaseEMFPB-- Ion transport proteinEMFPBAV DNA gyrase/topoisomerase IV, subunit A------V VPR/VPX protein------V Fusion glycoprotein F0------V E1 Protein, N terminal domainEM----- Alpha crystallin A chain, N terminalE------ Dictyostelium (slime mold) repeat------V E7 protein, Early proteinE--PBA- Binding-protein-dependent transport system inner membrane component----B-- HlyD family secretion proteinEM----- Scavenger receptor cysteine-rich domainEM----- Death domainEMFPBAV BRCA1 C Terminus (BRCT) domainEMFPBAV Glycosyl transferases group 1EMFPBAV Glycosyl transferase family 2EM----- SAM domain (Sterile alpha motif)EM-P--- Scorpion toxin-like domain EMFP--- linker histone H1 and H5 family------V Transactivating regulatory protein (Tat)------V gag gene protein p17 (matrix protein)EMFPB-- Ribosomal protein L7/L12 C-terminal domainE-FPB-- Pectate lyaseE-F-B-- ribonucleaseE-FPBA- Urease, gamma subunit------V 3C cysteine protease (picornain 3C)EMFPBA- CoA-ligaseEMFPB-- Phosphopantetheine attachment siteEMFPB-- Formyl transferaseEM----V Integrase DNA binding domainEM----V Rel homology domain (RHD)----B-- delta endotoxin----B-- Antenna complex alpha/beta subunitEMFPBA- Metallopeptidase family M24------V Vpu proteinEMFPB-V Leucine Rich RepeatEMFPBAV alpha/beta hydrolase foldEMFPBAV RNA polymerase Rpb2, domain 6----B-- EAL domainEMF---- PB1 domain

Sheet1

EMFPBA- Staphylococcal nuclease homologueEMF---- TBC domainEMF---- Tudor domainEMF---- WH1 domainEMFP--- Zinc finger, ZZ typeEMF-B-- HRDC domainEMFPBA- CBS domainEMFPBA- Ribosomal protein L13EMFPBA- Ribosomal protein L4/L1 familyEM-PB-- Clp proteaseEMFPBAV S1 RNA binding domainEMFPB-- HIUase/Transthyretin familyEMFPBA- AhpC/TSA familyEMF-BAV tRNA synthetases class I (W and Y)EMFPB-V UvrD/REP helicaseEMFPBA- Rhodanese-like domainE-FPBA- Universal stress protein familyEMFPBAV Acetyltransferase (GNAT) familyEMFPBA- SecE/Sec61-gamma subunits of protein translocation complexEMFPBA- AIR synthase related protein, N-terminal domainEMFPBA- tRNA synthetase class II core domain (G, H, P, S and T)EMF-BA- SpoU rRNA Methylase family----BAV Phage integrase familyEMFPBA- Tetrapyrrole (Corrin/Porphyrin) Methylases----B-- TonB dependent receptorEMFPB-- PDZ domain (Also known as DHR or GLGF)EMF-BA- Class II Aldolase and Adducin N-terminal domain------V Influenza Matrix protein (M1)------V Influenza Matrix protein (M2)------V Influenza non-structural protein (NS2)------V Influenza RNA-dependent RNA polymerase subunit PB1------V Influenza RNA-dependent RNA polymerase subunit PAEM----- Interferon regulatory factor transcription factor------V Herpesvirus Glycoprotein B------V Adenoviral fibre protein (repeat/shaft region)EM-P--- Diacylglycerol kinase accessory domainEMF---- Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)EMF---V Fes/CIP4 homology domainEMFP--- IQ calmodulin-binding motifEMFP--- Phosphoinositide 3-kinase family, accessory domain (PIK domain)EMFPB-V Phospholipase D Active site motifEMF---- Regulator of G protein signaling domainEMF---- GTPase-activator protein for Ras-like GTPaseEMF---- RasGEF domainEMF---- motifEM----- Caspase recruitment domainEMFP--- RhoGAP domainEMF---- RhoGEF domainEMF---- SPRY domainEMFPBAV RNA polymerase Rpb1, domain 2EMF-B-V Guanylate kinaseEMFP--- Gelsolin repeatEMFPBA- UBA/TS-N domainEMFP--- PHD-fingerEM----- MAM domainEM-P--- Filamin/ABP280 repeatEMF---- GGL domain

Sheet1

EMFP--V HECT-domain (ubiquitin-transferase)EMF-BA- Helix-hairpin-helix motifEM----- BRCA2 repeatEMF---- MSP (Major sperm protein) domainEMFPB-V RNase3 domainEMFP--- Region in Clathrin and VPSEMFP--- RanBP1 domainEMFPB-- PPIC-type PPIASE domainEM----- Phosphotyrosine interaction domain (PTB/PID)EMFP--- Zn-finger in Ran binding protein and othersEMFP--V Zinc finger C-x8-C-x5-C-x3-H type (and similar)EM-P--- B-box zinc fingerEM-P--V Poly(ADP-ribose) polymerase catalytic domainEMFP--- Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger regionEMFP--V F-box domainEMFP--- Elongation factor 1 gamma, conserved domainEMF-B-- Calpain family cysteine proteaseE-F---- Copper fist DNA binding domainEMFP--- CRAL/TRIO domainEMFP--V BTB/POZ domainEMFPB-V Ricin-type beta-trefoil lectin domainEMF---V Inhibitor of Apoptosis domainEMFPBA- Voltage gated chloride channelEMFPB-V Caspase domainEMFPB-- GDSL-like Lipase/AcylhydrolaseEMFP--- Poly-adenylate binding protein, unique domainEMFP--- POLO box duplicated regionE-F---- Seripauperin and TIP1 family------V Viral matrix proteinEMFPB-- NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminusEMFPB-V ABC transporter transmembrane regionEMFPB-V Integrase core domainEMFPB-- FAD binding domain----B-- Bacterial flagellin N-terminal helical regionEMFPBA- S-adenosyl-L-homocysteine hydrolase, NAD binding domainE---BA- HAMP domainEMFPBA- ribosomal L5P family C-terminusE-F---- DUP familyEMFPB-V Insulinase (Peptidase family M16)EMFPB-- Dehydrogenase E1 componentE-F-B-- Lumazine binding domainEMFPBA- Elongation factor G C-terminusEM----- Plectin repeatEMFPBA- HMGL-likeEM----- TB domainEMFPBAV DnaJ central domain (4 repeats)EM-PB-- Sulfotransferase domainEMFPB-- Starch binding domainEMFPBA- Ribosomal protein L1p/L10e familyEM----- TGF-beta propeptideEMFPB-- Cation transporting ATPase, C-terminusEMFPBA- Cation transporter/ATPase, N-terminus----B-- OmpA familyEMFPBAV dUTPase------V Thymidine kinase from herpesvirusEMFPBA- Aconitase C-terminal domain------V Major surface antigen from hepadnavirus

Sheet1

EMFPBA- Amino acid kinase familyE-F-BA- N-(5'phosphoribosyl)anthranilate (PRA) isomeraseEMF-B-- Acyl transferase domainE-FPBA- Urease beta subunit----B-- Bacterial flagellin C-terminal helical regionEMFPBA- Dihydrodipicolinate synthetase familyEMFPBA- haloacid dehalogenase-like hydrolaseEMFPB-- domainEMFPB-V Glycosyl hydrolases family 18EMFP-AV Proliferating cell nuclear antigen, N-terminal domainEM----- Anenome neurotoxinEMF-B-- Translation initiation factor IF-3, C-terminal domainEM--BA- AcylphosphataseEMFPBA- Adenylosuccinate synthetaseEMF-BA- AsparaginaseEM----- Beta defensin----B-- DNA polymerase III beta subunit, N-terminal domainEM----- HirudinEM----- Interferon gammaEM----- Interleukin 2------V Assemblin (Peptidase family S21)EMF-BAV Peptidase S24-like------V Polyomavirus coat proteinEMFPBA- Inorganic pyrophosphatase------V Virus coat protein (TMV like)EMFPB-- Glycosyl hydrolases family 16EMF-BA- Glycosyl hydrolases family 15E-FPB-- NADH:flavin oxidoreductase / NADH oxidase familyEM-PB-- 3-hydroxyacyl-CoA dehydrogenase, C-terminal domainEM----V Interleukin 10EM----- Interleukin 4EMF-B-- Glycosyl hydrolase family 20, catalytic domain------V Viral coat protein (S domain)EMFPBA- HhH-GPD superfamily base excision DNA repair proteinEMFPBA- AIR carboxylaseEMFPB-V GMC oxidoreductaseEMFPBAV Asparagine synthaseE-F---- Fungal cellulose binding domainEMF---- SeptinEMFP-A- EF-1 guanine nucleotide exchange domainE--PB-- Photosystem II 10 kDa phosphoprotein------V Trans-activation protein X------V Parvovirus coat protein VP2E-FPBA- Homoserine dehydrogenaseEMFPB-- Flavin-binding monooxygenase-likeE--PBA- Glutamyl-tRNAGlu reductase, dimerisation domain----B-- Gram positive anchor------V ssDNA binding proteinEM----- Calpain inhibitorEMFPBA- tRNA synthetases class I (E and Q), catalytic domainEMF-BAV tRNA synthetases class I (R)EM----- DM DNA binding domainEMFP-AV XPG N-terminal domainEMFPBA- Metallo-beta-lactamase superfamilyEMF-B-- F5/8 type C domainEMF-B-- Choline/Carnitine o-acyltransferaseEMFPB-- Putative esterase

Sheet1

EM----- Furin-like cysteine rich regionE--PB-- Glycosyl hydrolase family 9------V Polyomavirus coat proteinEMFPBA- FerrochelataseEMF-BA- Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domainEMFPBA- Arginosuccinate synthaseEMFPB-- Electron transfer flavoprotein FAD-binding domain------V Potyvirus coat proteinEM----- Ezrin/radixin/moesin family------V Adenovirus endoprotease----B-- FHIPEP familyE---B-V DnaB-like helicase N terminal domainEMF-B-- RNB domainE-F-B-- DioxygenaseEM----- Glycosyltransferase family 29 (sialyltransferase)EM----- DIX domainEM----- BTK motifEMF---- CNH domainEMFPB-- Diacylglycerol kinase catalytic domainEMFPB-V Dual specificity phosphatase, catalytic domainEM----- MyTH4 domainEMF---- P21-Rho-binding domainEMF---- PX domainEMF---- Ras association (RalGDS/AF-6) domainEMFP--- UBX domainEMF---- VHS domainEM----- ZU5 domainEMFP--- Phosphoinositide 3-kinase C2E-FPB-- DAHP synthetase I familyEM----- PI3-kinase family, ras-binding domainEMFPB-- Carbon-nitrogen hydrolaseE--PB-- Photosystem I reaction centre subunit VIII------V Arenavirus glycoprotein----B-V Geminivirus Rep catalytic domainE-FPBA- Prephenate dehydrataseEM--BA- PKD domain------V Pneumovirus attachment glycoprotein GEMFP--- SyntaxinEM-PB-- Pentapeptide repeats (8 copies)EMF---- Pumilio-family RNA binding repeatEM----- ApidaecinEMFP-A- Histone-like transcription factor (CBF/NF-Y) and archaeal histoneEMF-BA- Pterin binding enzymeEMFP--- ER lumen protein retaining receptorEM----- Ephrin----B-- FliP familyEMF-BA- Glycoprotease familyE-FPBA- Histidinol dehydrogenase----B-- H-NS histone familyEMF-BA- impB/mucB/samB familyEMF-BA- Phosphoenolpyruvate carboxykinaseEM----- PMP-22/EMP/MP20/Claudin familyEMFP-A- Ribosomal L15EMFPBA- Ribosomal protein L18e/L15EMFPB-- Ribosomal prokaryotic L21 proteinEMFPB-- Ribosomal L28 familyEMFPBA- Ribosomal L29 protein

Sheet1

EMFP-A- Ribosomal L39 proteinEMFP-A- Ribosomal S17EMFPBA- Ribulose-phosphate 3 epimerase familyEM-P--- SNAP-25 familyEM----- Stathmin familyEMFP--- Translationally controlled tumour proteinEM----- Cysteine rich repeatEM----- Sperm histone P2------V Arenavirus nucleocapsid protein------V Hantavirus nucleocapsid proteinE--P--- AP2 domain----B-- Ring hydroxylating alpha subunit (catalytic domain)EMFPB-- RNA pseudouridylate synthaseEMFPBA- Histone deacetylase domain------V Helper component proteinaseEM-P--V Glycosyltransferase family 10 (fucosyltransferase)EM----- Runt domainEMFPB-- POT familyEMFP--- PWWP domainEMFP--V SET domainEMF-B-- Isochorismatase familyEM----- Amiloride-sensitive sodium channelEM----- CTF/NF-I family transcription modulation regionEMFPBA- Permease familyEMFPBA- Ribosomal L18p/L5e familyEM----- ATP P2X receptorEM----- Osteopontin----B-- Ring hydroxylating beta subunitEMFP-AV XPG I-regionEM----- Transglutaminase familyEM----- P53 DNA-binding domain----BA- Acetokinase family----B-- Transposase, Mutator family----B-- AcrB/AcrD/AcrF family----B-- PRD domainEMFPBA- DNA photolyaseEM----- InnexinEM----- Cation-independent mannose-6-phosphate receptor repeatEM----- Defensin propeptideEM----- Nebulin repeatEMF-BA- Nitroreductase family----B-- Zinc dependent phospholipase CEMFPBA- Cytosol aminopeptidase family, catalytic domainEMFPB-- SulfataseEMFPB-- Ribosomal protein S16EMFP--- Acyl CoA binding proteinEMFP--V Cullin familyEMF-B-- Elongation factor TSEMFPBA- FAD binding domainEMFPBA- O-methyltransferaseEMFPBA- EamA-like transporter family----B-- Small Multidrug Resistance protein------V Luteovirus coat proteinEM----- ATP synthase protein 8EMFPBA- ThiF familyEMFP-A- Ribosomal family S4e------V Orbivirus outer capsid protein VP5

Sheet1

E--PB-- Sec-independent protein translocase protein (TatC)EMFPB-- Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily------V Hepatitis core antigenEM----- T-box----B-- dTDP-4-dehydrorhamnose 3,5-epimeraseEMFPBA- Ammonium Transporter Family----B-V RNA helicase----B-- TransglycosylaseE------ Trypanosome variant surface glycoprotein------V Calicivirus coat proteinEMFPB-- Sulfate transporter familyEMFP--- MATH domainEM----- Gastrin/cholecystokinin familyEM-PBA- Uncharacterized protein family UPF0004----B-- Borrelia lipoprotein------V Vesiculovirus phosphoproteinEMF-BA- TransaldolaseE-FPBA- Mechanosensitive ion channelEM----- Transglutaminase family, C-terminal ig like domainEMFP--- Adaptor complexes medium subunit familyEMFPB-V ExonucleaseEMF---- Dipeptidyl peptidase IV (DPP IV) N-terminal regionEM-PBA- NB-ARC domainEM----- Intermediate filament tail domainE-F-B-- Glycosyl hydrolase family 3 N terminal domain----B-- PE familyEMFP-A- Ribosomal protein L44----B-- BMC domain------V Coronavirus nucleocapsid protein----B-- LipoproteinEMFPBA- Sodium:sulfate symporter transmembrane regionEMFP--V DNA-dependent RNA polymeraseEMFPB-- FAD binding domain in molybdopterin dehydrogenase------V Alphavirus core protein ------V Rhabdovirus nucleocapsid protein------V Picornavirus core protein 2A------V Flavivirus non-structural Protein NS1 ----B-V Peptidase S7, Flavivirus NS3 serine protease E---B-- ABC 3 transport family------V Arterivirus GL envelope glycoproteinEMFPBA- Glycosyl transferase family 4E--P--- S-locus glycoprotein familyEMFP--- HCO3- transporter familyEMF---- Nucleosome assembly protein (NAP)EMFP--- SynaptobrevinEMF-BA- GMP synthase C terminal domainE---B-V Phage lysozyme----B-- Neocarzinostatin familyE-FP-A- LAGLIDADG endonucleaseEMFPB-- Adenosine/AMP deaminase----B-- Cohesin domainE------ ElicitinEM----- Tissue inhibitor of metalloproteinaseE--P--- Barwin familyEMFPBA- Oxidoreductase FAD-binding domain------V EIAV coat protein, gp90------V Flavivirus RNA-directed RNA polymerase

Sheet1

------V Paramyxovirus nucleocapsid protein------V Rhabdovirus spike glycoproteinEMF-B-- Thioesterase domainEM----- Corticotropin ACTH domainE-FPBA- Histidine biosynthesis protein------V RNA dependent RNA polymerase------V Reovirus outer capsid protein, Sigma 3------V Rotavirus major capsid protein VP6------V Rotavirus RNA-binding Protein 53 (NS53)E-FPB-- Glycosyltransferase family 20EM-PBA- UDP-glucose/GDP-mannose dehydrogenase family, central domainE------ Merozoite Surface Antigen 2 (MSA-2) familyE--PBA- DNA gyrase B subunit, carboxyl terminusEMF-BA- Carbamoyl-phosphate synthase small chain, CPSase domainEMFPBA- PAS fold----B-- GGDEF domainEM----- TroponinEMFPBA- Probable molybdopterin binding domainEMFP--- Sec1 familyEMF---- GDP dissociation inhibitorEMFPBA- Sodium/hydrogen exchanger familyEMFPBA- RNA polymerase Rpb3/RpoA insert domain------V Hepatitis C virus non-structural protein NS4b------V Flavivirus non-structural protein NS2B------V Flavivirus capsid protein C------V Flavivirus envelope glycoprotein MEM----- Inward rectifier potassium channelEMF-BA- Initiation factor 2 subunit familyE--PB-- NADH-Ubiquinone oxidoreductase (complex I), chain 5 C-terminusEM--BA- PQQ enzyme repeatEMFPB-- Electron transfer flavoprotein domainEMFPB-- UricaseEMFP-A- Ribosomal S3Ae familyEMFPB-- Ribosomal L27 proteinEM----- STAT protein, all-alpha domainEMF-B-- GTP1/OBGEMF-B-- Gamma-glutamyltranspeptidaseEMFP-A- Ribosomal L40e familyE-F---- TYA transposon protein----BAV Bacterial regulatory protein, arsR family----B-- Colicin pore forming domainEMF-BA- GrpEEMF-BA- TatD related DNaseEMFPB-V Uncharacterised protein family UPF0005EMFP--V Eukaryotic DNA topoisomerase I, catalytic core----B-- NusB familyEMF---- Receptor L domainEMFP--- Dynamin central region----BA- FecCD transport familyEM----- Somatomedin B domainEM----- Syndecan domainEMF-BAV 6-O-methylguanine DNA methyltransferase, DNA binding domain----BA- AsnC familyEMFPB-- Carboxyl transferase domainEMFPBA- UbiA prenyltransferase family----BAV DegT/DnrJ/EryC1/StrS aminotransferase familyEMF-BA- Endoribonuclease L-PSP

Sheet1

E--PB-- SecA preprotein cross-linking domainEM----- Vinculin family----BA- MarR familyEMFPBAV Phosphorylase superfamilyEM----- Cadherin cytoplasmic region----B-- Initiator Replication protein----B-- Surface presentation of antigens (SPOA)EMFPBA- Cys/Met metabolism PLP-dependent enzyme------V Mouse mammary tumour virus superantigenEMFPBA- Glycosyl hydrolases family 31 EM----V Myc amino-terminal region------V Parvovirus non-structural protein NS1EMFPBA- NADH ubiquinone oxidoreductase, 20 Kd subunitEM-PB-- NADH-ubiquinone oxidoreductase chain 4, amino terminusEM----- Transthyretin-like familyEMFPB-- ABC-2 type transporterEM-PB-- BestrophinEMFPBA- Aminotransferase class IVEM----- Activin types I and II receptor domain------V Hexon, adenovirus major coat protein, N-terminal domainEMFPBA- CDP-alcohol phosphatidyltransferaseEMF---- Calpain large subunit, domain IIIEMFPBAV ATP dependent DNA ligase domainEMFPBA- FMN-dependent dehydrogenaseEMFPBA- Phosphoribosylglycinamide synthetase, ATP-grasp (A) domainEMFP--V 3-beta hydroxysteroid dehydrogenase/isomerase familyEMF-B-- Glycosyl hydrolases family 38 N-terminal domain----B-- Glycosyltransferase family 9 (heptosyltransferase)E-FPBA- Nitrite and sulphite reductase 4Fe-4S domainE--PBA- Magnesium chelatase, subunit ChlIEM----- Hint moduleEM-P--- Presenilin----B-- KDPG and KHG aldolaseEM----- Copper type II ascorbate-dependent monooxygenase, N-terminal domainE-F-B-V CutinaseEMFPB-- Ribosomal protein S18EM----- Hedgehog amino-terminal signalling domainEMF---- Clathrin light chainEMFPB-- Galactose-1-phosphate uridyl transferase, N-terminal domainEMF---- Ubiquitin carboxyl-terminal hydrolase, family 1EMFP-A- Ribosomal protein S19eEM----- PTN/MK heparin-binding protein family, C-terminal domainEMFP-A- Ribosomal protein S6eEM----- ClusterinEM-PBA- Receptor family ligand binding regionEMF--AV Transcription factor S-II (TFIIS)EMF---- Arthropod defensinEM----- Uteroglobin familyEM----- HMG14 and HMG17EMF---- Glycophorin AEMFPB-- Surface antigen------V Bunyavirus non-structural protein NS-sEMF---- emp24/gp25L/p24 family/GOLDEMFPB-- NifU-like domain------V Viral movement protein (MP)EM----V Tissue factorEM----- Granulocyte-macrophage colony-stimulating factor

Sheet1

EMFP--- Cyclin-dependent kinase regulatory subunitEMFPBA- AsparaginaseE--PBA- Dihydrodipicolinate reductase, N-terminusEMFP--- F-actin capping protein, beta subunitE-F-B-- Fructose-bisphosphate aldolase class-IIEMFPBA- Semialdehyde dehydrogenase, NAD binding domainEMF-BA- DNA mismatch repair protein, C-terminal domainEM-P--- Alpha-L-fucosidaseEMF-BA- Dephospho-CoA kinaseEM----- Eukaryotic cobalamin-binding protein----B-- Staphylococcal/Streptococcal toxin, OB-fold domainEM--B-- MAPEG familyEMFP--- G10 proteinEMF-B-- Heme oxygenaseEMFPBA- Succinate dehydrogenase/Fumarate reductase transmembrane subunitEM-PBA- Uncharacterized protein family UPF0007EM----- NAD:arginine ADP-ribosyltransferaseEM----- CD36 familyEMF-BAV DNA topoisomerase----B-- Elongation factor P (EF-P) OB domainEM-P--- Enhancer of rudimentaryEMF-BA- Glucose inhibited division protein AEMFPBA- Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)----BA- Peptidase family U32EMFPBA- RNA 3'-terminal phosphate cyclaseEMF-BA- 3' exoribonuclease family, domain 1EM--BA- Uncharacterized protein family UPF0027EM----V Matrix protein (MA), p15------V Gag polyprotein, inner coat protein p12EMF-BA- tRNA pseudouridine synthase D (TruD)EM--BA- Coenzyme A transferaseEMFPBAV SPFH domain / Band 7 familyEM----- CaveolinEM----- Crustacean CHH/MIH/GIH neurohormone familyEMFPBA- Cytidylyltransferase familyEMFP--- GDA1/CD39 (nucleoside phosphatase) familyEMF---- GNS1/SUR4 familyE--PB-- Bacterial-like globinEM----- GlypicanEMFPBA- Hydroxymethylglutaryl-coenzyme A synthase N terminal----BA- Hydrogenase expression/synthesis hypA familyE-F-BA- Inosine-uridine preferring nucleoside hydrolaseEMFP-A- Ribosomal protein L21eEMFP--- Ribosomal protein L36eEMFP--- Ribosomal protein L6e EM----- Vertebrate endogenous opioids neuropeptideEMFPBAV Phosphatidylethanolamine-binding proteinEMF--A- RIO1 familyEMFPB-- Ribosomal protein S21EM----- TSC-22/dip/bun familyEM-P--- Tub familyEMF-B-- Alanine racemase, N-terminal domainEMF-B-- Uncharacterized protein family UPF0016EMF-BA- Putative RNA methylase family UPF0020EMFPBA- PP-loop familyEMF--A- Shwachman-Bodian-Diamond syndrome (SBDS) protein E-FPBA- SNO glutamine amidotransferase family

Sheet1

EMFPBA- Translation initiation factor 1A / IF-1EMFPB-- Copper amine oxidase, enzyme domainEMFPBA- Dihydroorotate dehydrogenaseEMFPB-- Glucosamine-6-phosphate isomerases/6-phosphogluconolactonaseE-F---- Fungal hydrophobinEM----- Lysyl oxidase EM--BA- Mandelate racemase / muconate lactonizing enzyme, C-terminal domainEMF-BA- NOL1/NOP2/sun familyE--P--- Pollen proteins Ole e I likeEMF--AV RNA polymerase Rpb5, C-terminal domainEMFPBAV RNA polymerase Rpb6 EMFPBA- RNA polymerase Rpb3/Rpb11 dimerisation domainEMFP-AV RNA polymerases N / 8 kDa subunitEMFPB-- Ribosomal protein L17E--PB-- Ribosomal protein L31EMFP-A- Ribosomal protein L31eEMFP-A- Ribosomal protein L34eEMFP-A- Ribosomal protein S28eEMFP-A- Ribosomal protein S8eEMFPBA- Shikimate kinase----B-- Bacterial type II secretion system protein NEMF-B-- TrehalaseEMF-B-- Uncharacterized protein family UPF0029----BA- SirA-like proteinEMFPBA- Dihydrouridine synthase (Dus)EMFPBA- Uroporphyrinogen decarboxylase (URO-D)EMFPB-- ubiE/COQ5 methyltransferase familyEMFPBA- NAD-dependent glycerol-3-phosphate dehydrogenase N-terminusEMF-BA- Beta-eliminating lyaseEMF---- Adenylate cyclase associated (CAP) N terminalEMFP--- Casein kinase II regulatory subunitEMF---- Cytochrome c oxidase subunit VbEM----- CalsequestrinEMFP--- Clathrin adaptor complex small chainEMFPB-- Coproporphyrinogen III oxidase----B-- Prokaryotic diacylglycerol kinaseE-F-B-- Dehydroquinase class IIEMFP--- Dynein light chain type 1 EMFP--V Ergosterol biosynthesis ERG4/ERG24 familyEMF-B-- DNA/RNA non-specific endonuclease----B-- Mur ligase family, catalytic domainE-F-BA- Formate/nitrite transporterEMFPBA- GTP cyclohydrolase IE--PB-V Glycine radicalEM--B-- Glycosyl hydrolases family 39EMFPBA- HIT domainE-F-B-- Mannitol dehydrogenase Rossmann domainEMFP--V Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domainEM----- NNMT/PNMT/TEMT family----B-- Sodium:alanine symporter familyEMF---- Oxysterol-binding protein EMF-B-- Phosphomannose isomerase type IEMFP--- Protein prenyltransferase alpha subunit repeatE--PB-- Photosystem I psaG / psaKEM--BA- 6-pyruvoyl tetrahydropterin synthaseEMF-BA- Pyridoxamine 5'-phosphate oxidaseEMF-B-- Membrane dipeptidase (Peptidase family M19)

Sheet1

EMFPB-- Ribosomal protein L19EMFP-A- Ribosomal protein L24eEMFP-A- Ribosomal protein L35AeEMFPBA- Ribosomal protein L7Ae/L30e/S12e/Gadd45 familyEMFP--- Ribosomal protein S21e EMFPB-- Ribosomal protein S6EMFP--- Ribosomal protein S7e----B-- Signal peptidase (SPase) IIEMFPBAV Translation initiation factor SUI1EMFPBA- Putative undecaprenyl diphosphate synthaseEMF-BA- Carbohydrate kinaseEMFPB-- Respiratory-chain NADH dehydrogenase 24 Kd subunit----B-V Prokaryotic dksA/traR C4-type zinc fingerEMFPBA- SAICAR synthetaseEMFPBAV Xylose isomerase-like TIM barrelEMFPB-- Alanine dehydrogenase/PNT, C-terminal domainEMFPB-- Aldose 1-epimeraseEMF---- Cytochrome c/c1 heme lyaseEMFPBA- FAD dependent oxidoreductaseEMFP--- F-actin capping protein alpha subunitEMFPBA- Formate--tetrahydrofolate ligaseEMFP-A- FibrillarinEM----- Granin (chromogranin or secretogranin)----B-- Transcription elongation factor, GreA/GreB, C-termEM-P--- LBP / BPI / CETP family, N-terminal domainEMFPB-- Malate synthaseEM----- Myelin proteolipid protein (PLP or lipophilin)----B-- Orn/Lys/Arg decarboxylase, major domainE--P--- OleosinEM----- Parathyroid hormone familyEMFP-A- Ribosomal protein L19eEMFPB-- Ribosomal protein L9, N-terminal domainEMFP-A- Ribosomal protein S24eEMFP--- Ribosomal protein S26eEMF---- Membrane-associating domainEMF---- TEA/ATTS domain familyEMF---- XPA protein N-terminalEMFP-A- Eukaryotic elongation factor 5A hypusine, DNA-binding OB foldE-F-B-- 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)EM----- Thymosin beta-4 familyEM----- LIF / OSM family----B-- Prokaryotic cytochrome b561EMFP-A- Ribosomal protein L13e----B-- Periplasmic solute binding protein family----B-- Transferrin binding protein-like solute binding proteinEM----- Lysosome-associated membrane glycoprotein (Lamp)EMF-BA- yrdC domainEMFPB-- Glycosyl hydrolases family 35EMF---- CAP-Gly domainEM----- Egg lysin (Sperm-lysin)----B-- Gas vesicles protein GVPc repeated domain----B-- LacY proton/sugar symporter------V Plant viral movement protein----B-- Chlamydia major outer membrane protein----B-- Bacterial export proteins, family 1----B-- FlhB HrpN YscU SpaS Family----B-- Bacterial export proteins, family 3

Sheet1

----BA- Aldehyde ferredoxin oxidoreductase, domains 2 & 3EMFPB-- Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain----B-- Arginine repressor, DNA binding domain------V Bromovirus coat protein----B-- Colicin immunity protein / pyocin immunity proteinEMF-BA- Creatinase/Prolidase N-terminal domain----B-- Cytochrome C'EM--B-- DSBA-like thioredoxin domain------V Diphtheria toxin, R domain----BA- Iron dependent repressor, N-terminal DNA binding domainE--PBA- Pyruvate phosphate dikinase, PEP/pyruvate binding domainEM-PB-- Polypeptide deformylaseE-F---- Peroxidase, family 2EMF-BA- Pterin 4 alpha carbinolamine dehydratase----B-- RuvA N terminal domainEMF---V mRNA capping enzyme, catalytic domainEM----V Death effector domainEMFPBA- OB-fold nucleic acid binding domain----B-- Barstar (barnase inhibitor)----BA- CheB methylesterase----B-- Met Apo-repressor, MetJEM----- SAND domain----BAV Peptidase family S49EMFPBAV Kelch motif----BA- Domain of unknown function DUF11----B-- Domain amino terminal to FKBP-type peptidyl-prolyl isomeraseEM----- Lipoprotein amino terminal regionE-FPB-- Type II intron maturase------V Flavivirus non-structural protein NS4B------V Flavivirus non-structural protein NS4AEMFPBA- Ribonuclease HIIEM----- KRAB boxEM----- Green fluorescent protein----B-- High potential iron-sulfur protein----B-- Alpha amylase inhibitorEM----- Transposase----B-- Tautomerase enzymeEMF---V FYVE zinc finger----B-- Peptidase family C25EM----- RIH domain------V Herpesvirus processing and transport protein----B-V 5'-3' exonuclease, C-terminal SAM foldEMF-BAV DHH familyEMFP--- Sec7 domainEMFPBAV NAD dependent epimerase/dehydratase family----B-- Trp repressor proteinEM----- Melittin----B-- Heat-labile enterotoxin alpha chain----B-- Heat-labile enterotoxin beta chain----B-- B domainEMFPBA- Porphobilinogen deaminase, dipyromethane cofactor binding domainEMF-BAV SIS domainEMFPBAV Helix-turn-helixEM--B-- Avidin familyEMFPBA- Phosphate transporter family----BAV Probable transposase----B-- Ribosomal L25p family

Sheet1

EM----- SynucleinEMF---- ARID/BRIGHT DNA binding domainEM----- SEA domainEM---AV Collagen triple helix repeat (20 copies)EM----- Fz domainEMF---- Chromo shadow domainEMF---- Clathrin propeller repeatEM----- PBP/GOBP familyEM--BA- Topoisomerase DNA binding C4 zinc fingerE--P--- Terpene synthase, N-terminal domainEMFPB-- Mov34/MPN/PAD-1 familyEMFP--- PCI domainEM--B-- Astacin (Peptidase family M12A)EM----- Angiotensin-converting enzyme----BAV Ribbon-helix-helix protein, copG familyEM----V Sema domainEM----- Ephrin receptor ligand binding domainE--PB-- Photosystem II reaction centre T proteinEMF-BAV tRNA synthetases class I (C) catalytic domain------V Geminivirus AL3 proteinEMFPB-- Oxidoreductase family, NAD-binding Rossmann foldEMFPBA- tRNA synthetases class II core domain (F)EM----- Fibrillar collagen C-terminal domainEMFPBA- tRNA synthetases class II (A)EMFP--- Putative GTPase activating protein for ArfEM----- C-terminal tandem repeated domain in type 4 procollagenEM----- Delta serrate ligandEMFPBA- tRNA pseudouridine synthaseEMFP-A- ENTH domain----B-- Helix-turn-helix domain, rpiR familyEMFP--- Jacalin-like lectin domain----BA- Type I restriction modification DNA specificity domainEMF---- Reprolysin (M12B) family zinc metalloprotease EMF---- NF-X1 type zinc fingerEMFPBA- LSM domain EMF-B-V R3H domainEMF-BA- AmidaseEMFP--- BAH domainEMFP--- AN1-like Zinc fingerEM----- Methyl-CpG binding domainEM--B-V Peptidase family M13EMF-B-- Peptidase family M3EMF-BA- Peptidase family M1EMFPB-- Peptidase family M41EMFPBA- Peptidase family M48EM--B-- NHL repeatEM----- Plexin repeatE--P--- Metallothionein----B-- LipoproteinEM----- Apolipoprotein A1/A4/E domainE-F-BAV Viral (Superfamily 1) RNA helicase------V Viral small hydrophobic protein----B-- Replication proteinEM----- ELM2 domainE-FPBA- Acetohydroxy acid isomeroreductase, catalytic domainEMF-B-- Low molecular weight phosphotyrosine protein phosphatase------V Rotavirus non structural protein

Sheet1

E--P--V D-mannose binding lectinEMF---- MAGE family

Mucin-like glycoproteinEM----- LeishmanolysinEMFP--- Eukaryotic porinEM----- Leucine rich repeat N-terminal domainEM----- Leucine rich repeat C-terminal domainEM--B-V Transglycosylase SLT domainEMFP--- GRIP domainEMFP--- Skp1 family, dimerisation domainEMFPBA- Cytidylyltransferase----B-- GA module----B-- Pentapeptide repeats (8 copies)EM--BA- Pyroglutamyl peptidaseEM-PB-- Putative peptidoglycan binding domainEMFPBA- PUA domain----B-V Putative cell wall binding repeatE-FPB-- Class-II DAHP synthetase family----BA- Ferric uptake regulator familyEMFPB-V LysM domainEM-PB-- PLAT/LH2 domainEMFPBA- S4 domainEMF---- PWI domainEMF-B-V Proprotein convertase P-domainEM----- Nematode cuticle collagen N-terminal domainEMFP--V IBR domainE--P--- K-box regionE-FPBA- Type I 3-dehydroquinaseE-FPBA- Shikimate / quinate 5-dehydrogenaseEMFPB-- Transmembrane amino acid transporter proteinEMFPB-- Frataxin-like domain------V Geminivirus C4 proteinE-FPBA- GXGXG motifEMFPBA- FAD binding domainEMF-BA- V-type ATPase 116kDa subunit family ----BA- Periplasmic binding proteinEM----- Transposase------V Herpesvirus UL25 familyEM----- Keratin, high sulfur B2 proteinEMFPB-V Glycosyl transferase family 8E-FPBA- Phosphoribosyl-AMP cyclohydrolaseEMFP--- Phosphatidylinositol-4-phosphate 5-KinaseEMFPBAV Phosphoadenosine phosphosulfate reductase familyE------ Paramecium surface antigen domainEMFPBA- TruB family pseudouridylate synthase (N terminal domain)EM--B-V N-acetylmuramoyl-L-alanine amidaseEMF-B-- Respiratory-chain NADH dehydrogenase 51 Kd subunitEMFPBA- ATP-NAD kinase----BA- Phosphate acetyl/butaryl transferase------V Orbivirus helicase VP6------V Hepatitis delta virus delta antigen------V Sigma NS protein----B-- Protein of unknown function DUF16EMFPB-- Iron-sulphur cluster biosynthesisE-F-B-- Polysaccharide deacetylase----BA- Putative modulator of DNA gyrase------V Geminivirus V1 protein

Sheet1

------V Rotavirus NS26----B-- TransposaseEM--B-- Transposase------V Herpesvirus glycoprotein MEMFP--- DHHC zinc finger domainEM----- Zinc finger, C2HC typeEM----- Glycosyl transferase family 11EMF---- Glycosyl hydrolase family 47------V Tospovirus nucleocapsid proteinEM----- Frizzled/Smoothened family membrane regionEMFP--- PPR repeatEMFP--- Adenosylmethionine decarboxylase------V Herpesvirus glycoprotein D/GG/GX domain------V Hepatitis C virus non-structural protein NS2------V Hepatitis C virus envelope glycoprotein E1

Adhesin lipoproteinEMF-BAV GIY-YIG catalytic domainE-F-BA- CorA-like Mg2+ transporter proteinEMFPBA- Cation efflux familyEMFPBA- Peptidase family M20/M25/M40----BA- Bacterial extracellular solute-binding protein----B-- TransposaseEM----- ShK domain-likeEM--B-- Peptidase family M23------V Picornavirus 2B proteinEMFPB-- Acyltransferase----BAV DNA methylaseEMFPBAV DnaJ C terminal regionEMF-BA- Fumarylacetoacetate (FAA) hydrolase familyE---BA- Pyruvate ferredoxin/flavodoxin oxidoreductase------V Hepatitis C virus non-structural protein E2/NS1EM----- Reprolysin family propeptideEMFPBA- Spermine/spermidine synthaseEMFPB-- FAD binding domain EMFPB-- Natural resistance-associated macrophage protein----BA- Molydopterin dinucleotide binding domainEMFPBA- PAP2 superfamily------V Flavivirus polyprotein propeptideEMFPBA- Aminomethyltransferase folate-binding domainEMF-B-- MaoC like domainEM----- Myosin tail------V Potyvirus P1 proteaseE--PB-- Cytochrome C assembly proteinEM----- Domain of unknown function DUF19----B-- FtsK/SpoIIIE familyEM----- FMRFamide related peptide familyEM-PB-- TIR domainEMFPBA- Adenylylsulphate kinase----B-- CheW-like domainEMFP--V G-patch domainEM----- Myogenic Basic domainEMFPBA- Putative tRNA binding domainEMFPB-- GAF domainEMF---- 6-phosphofructo-2-kinaseEMF-B-- NifU-like N terminal domainEMFPBAV Flavin containing amine oxidoreductaseEM--BA- Domain of unknown function DUF20

Sheet1

EMF-B-- Domain of unknown function DUF21EMFPB-- O-methyltransferaseEMFPBA- Glycine cleavage H-proteinEMFP-A- Ribosomal protein S27a------V Coronavirus S2 glycoproteinEMFP--- Adaptin N terminal regionEMFP--- Protein phosphatase 2A regulatory B subunit (B56 family)------V Arterivirus envelope proteinEMF---V Chitin binding Peritrophin-A domainEMF---- I/LWEQ domain----BA- Transposase DDE domain----B-- Transposase------V Filovirus glycoproteinEMFPB-V 3'-5' exonucleaseE-F-BA- Flavin reductase like domain------V Orbivirus NS3----BA- MotA/TolQ/ExbB proton channel familyEMFPB-- Proline dehydrogenaseE--P--- Ribonuclease (pollen allergen)----B-V Cell fusion glycoprotein KEMFPBAV MutS domain IEMFPBA- Peptide methionine sulfoxide reductaseE-FPB-- Hpt domain----B-- HrcA protein C terminal domain-----A- Domain of unknown function DUF22EM----- HyaluronidaseEMFPB-- Ribosomal protein L35EMF-B-- Choline/ethanolamine kinaseEMFPB-- Phosphotransferase enzyme familyEM--BAV Archaeal ATPase----BA- HxlR-like helix-turn-helix------V Viral family 110EMF-BA- SelR domainEM--B-- Methylmalonyl-CoA mutaseE--PB-- Acyl-ACP thioesteraseE-F---- Chitin synthaseE-FPBA- Conserved region in glutamate synthaseEMF-B-- 4'-phosphopantetheinyl transferase superfamilyE--PB-- Ribosomal protein S20EMFP--- Peptidase C13 familyEMFP--V Eukaryotic initiation factor 4EEM--B-- Bacterial Cytochrome Ubiquinol OxidaseEMFP-A- Ribosomal protein L32E--PBA- CobQ/CobB/MinD/ParA nucleotide binding domainE--P--- Domain of unknown function DUF26EMFPB-- Myo-inositol-1-phosphate synthase------V Viral methyltransferaseEMFPBAV Macro domainEMF---- Type I phosphodiesterase / nucleotide pyrophosphatase------V Rotavirus non-structural protein NSP3

DX moduleEMFP-A- Ribosomal protein S27E-F-B-- Glycosyl hydrolase family 12------V African swine fever virus multigene family 360 protein

Putative plasmid partition protein------V Herpesvirus putative major envelope glycoprotein----B-- Lipase (class 2)

Sheet1

E--PBA- Metalloenzyme superfamilyE--PBA- Diaminopimelate epimeraseEMFPBA- SOR/SNZ familyEM----- C6 domainEM----- DB moduleEM----- EB module

ET moduleEMF-B-- Riboflavin kinase------V Alphaherpesvirus glycoprotein I------V Potato leaf roll virus readthrough protein------V Adenovirus E1B 19K protein / small t-antigen------V Paramyxovirus non-structural protein cEMF-B-V Caulimovirus viroplasminEMFPB-V Rhomboid family----B-- IstB-like ATP binding protein------V Adenovirus EB1 55K protein / large t-antigenEM----- Domain of unknown functionE--P--- Floricaula / Leafy proteinEMFPBA- Sodium/calcium exchanger proteinE--PB-- Photosystem I reaction centre subunit IX / PsaJEMF-BA- Queuine tRNA-ribosyltransferaseEMFPB-- UTP--glucose-1-phosphate uridylyltransferase------V Geminivirus putative movement protein EMFPB-- Domain of unknown function DUF28

TransposaseEM--B-V Deoxynucleoside kinaseEMF-B-- Smr domainEMF-B-- IPP transferase------V Orbivirus non-structural protein NS1, or hydrophobic tubular protein----B-- Plasmid replication proteinEMFPB-- BolA-like protein

Domain of unknown function DUF29EMF-BA- Ham1 family----B-- LexA DNA binding domainEMF-BAV FtsJ-like methyltransferaseEMF-BA- Quinolinate phosphoribosyl transferase, C-terminal domainE-F-B-- UreFEM----- Arylesterase----B-- Domain of unknown function DUF31EMF---- Nucleoside transporterEMFPB-V Patatin-like phospholipaseEMF---- Lysophospholipase catalytic domainE--PB-- YCF9EMFPBA- Dienelactone hydrolase family----B-- CheR methyltransferase, SAM binding domainEMFPB-- STAS domain----B-- Large-conductance mechanosensitive channel, MscL----B-- Clostridial neurotoxin zinc proteaseEMF-B-- Poly A polymerase head domain----B-- GLTT repeat (6 copies)E---B-- Isopentenyl transferaseEMF-B-- tRNA (Guanine-1)-methyltransferaseEMF-BA- ATP-sulfurylaseEMFP--- Importin beta binding domain----BA- Hydrogenase maturation proteaseEMFPBAV Toprim domainEMFP--V MYND finger

Sheet1

EM-P--- A20-like zinc fingerEM--B-V Glycosyltransferase family 25 (LPS biosynthesis protein)EMFP--- Acyl-CoA oxidaseEM--B-V Acyltransferase familyEMF-B-- Sodium Bile acid symporter familyEM----- UNC-6/NTR/C345C moduleE-F-BA- 3-dehydroquinate synthaseEM-P--- Galactosyltransferase------V Herpesvirus UL6 likeEMFPB-- Lipase (class 3)EMFPB-- Ribosome recycling factor------V Birnavirus VP2 protein------V Birnavirus VP3 proteinEM--B-- Divalent cation transporterEM----- Reduced folate carrier------V Herpesvirus alkaline exonucleaseEM--B-- Na+ dependent nucleoside transporter N-terminusE-F-BA- UreD urease accessory proteinEMFP-A- Ribosomal L18ae/LX protein domainEMFP--- Ribosomal L22e protein familyEMFP--- Ribosomal L27e protein familyEMFP--- Ribosomal L28e protein familyEMFP--- Ribosomal L29e protein familyEMFP-A- Ribosomal L37ae protein familyEMFP-A- Ribosomal L38e protein family----B-- RimM N-terminal domainEMFPB-- Ribosomal L32p protein familyEMF-BA- NIF3 (NGG1p interacting factor 3)E-FP--- Alternative oxidaseE--PB-- PsbJ----B-- Prolipoprotein diacylglyceryl transferaseEM--BA- DeoC/LacD family aldolaseE-F---- Glycolipid 2-alpha-mannosyltransferaseEMFPBA- Ferric reductase like transmembrane componentEM--B-- MraW methylase family-----A- DUF35 OB-fold domain----B-- Transposase IS200 likeEMFP-A- Putative snoRNA binding domainEMFPB-- [2Fe-2S] binding domainEMF---- LIM-domain binding proteinEMFP--- Surp module------V Paramyxovirinae P phosphoprotein C-terminal region----B-V CHC2 zinc fingerEMF-B-- AICARFT/IMPCHase bienzymeE--PB-V Domain of unknown function DUF37----B-- LysE type translocatorEMF-B-- 5-formyltetrahydrofolate cyclo-ligase familyEMFPBA- ATP synthase subunit D EM--BA- Hemerythrin HHE cation binding domain----B-- Rop proteinE-FPBA- Chorismate mutase type II------V Bacteriophage translational regulator------V Levivirus coat protein----B-- D-ala D-ala ligase N-terminusEMF---- WSC domainEM----- MAC/Perforin domainE--P--- MatK/TrnK amino terminal region

Sheet1

EM----- Latrophilin/CL-1-like GPS domainEM----- Trypsin Inhibitor like cysteine rich domainEM----- FTH domainEMFPB-- IPT/TIG domainEM----- XRCC1 N terminal domainEM--B-- MG2 domain-----A- Domain of unknown function DUF39EM--B-- FG-GAP repeatEM----- TCL1/MTCP1 familyEMF-B-- Transglutaminase-like superfamilyEMFPBA- ACT domainEMF---- DIL domainEM-PB-V HNH endonuclease----B-- CcdB proteinEMF---- FF domainEM----- von Hippel-Lindau disease tumour suppressor protein----B-- Hok/gef familyEMFP-A- NAC domain----BA- PIN domainEMF---- Proteasome/cyclosome repeatEM-PB-- START domainEMFP--- MOZ/SAS family

Helicobacter outer membrane proteinEM-P--- Retinoblastoma-associated protein B domainEM-P--- Retinoblastoma-associated protein A domain----BA- Protein of unknown function DUF43----BA- Protein of unknown function DUF45-----A- Putative integral membrane protein DUF46----BA- Protein of unknown function DUF47EMF--A- Putative diphthamide synthesis protein----BA- CRISPR associated protein Cas1EMF--A- Domain of unknown function UPF0086EM--BA- BadF/BadG/BcrA/BcrD ATPase family-----AV Archaeal holliday junction resolvase (hjc)EMFPBA- AMMECR1EMFP-A- Domain found in IF2B/IF5EMF-BA- Memo-like proteinEMF--A- RNase P subunit p30-----A- Protein of unknown function DUF54EMF-BA- Protein of unknown function DUF55-----A- CRISPR associated protein Cas6----B-- Protein of unknown function DUF58EMFPBA- Domain of unknown function DUF59----BA- PcrB familyEMF-BA- RNA 2'-phosphotransferase, Tpt1 / KptA family-----A- Membrane protein of unknown function DUF63----BA- Cobalamin synthesis G C-terminus----BA- Cobalt uptake substrate-specific transmembrane region-----A- Uncharacterised protein family UPF0058E-F-BA- Uncharacterised protein family UPF0047----BA- PhoU domainEMF-BAV Eukaryotic and archaeal DNA primase small subunit----BA- Na+/H+ ion antiporter subunitEMFP-A- Rpp14/Pop5 familyEMF--A- ATP-binding region----B-- Protein of unknown function DUF72-----A- CRISPR-associated negative autoregulator DevR/Csa2

Sheet1

----BA- Domain of unknown function (DUF74)EMFP-A- Ribosomal protein L37eEMF-BAV Nucleotidyltransferase domainE-F-BA- Domain of unknown function DUF77EMFP-A- eIF-6 family----BA- lobeE-FPB-- Glycosyl hydrolase family 3 C terminal domainEMFPBA- Deoxyhypusine synthase-----A- Archaebacterial flagellinEMFP-A- AlbaEMFPBA- Prefoldin subunit----BA- tRNA synthetases class I (K)EMFP-A- SRP19 proteinEM--B-- Cobalamin adenosyltransferase----BA- Hydrogenase formation hypA family----BA- Sulfite exporter TauE/SafEEMFPBA- GTPase of unknown functionEM----- Protein of unknown function DUF82EM--BA- CYTH domainEMFP-A- Ribosomal protein L14-----AV Domain of unknown function DUF83EM--BA- Protein of unknown function DUF84E-F-BA- Uncharacterised protein family UPF0052----BA- Protein of unknown function DUF86----BA- Domain of unknown function DUF87EM--BA- Protein of unknown function DUF88EMFP-A- Protein of unknown function DUF89EMFPBA- TRAM domainEM--BA- Integral membrane protein DUF92----BA- S-adenosylmethionine synthetase (AdoMet synthetase)----BA- Polysaccharide biosynthesis protein----BA- Integral membrane protein DUF95EMFPBA- Thi4 familyE---BA- Protein of unknown function (DUF98)----BA- Aspartate carbamoyltransferase regulatory chain, allosteric domainEM---A- Archease protein family (DUF101/UPF0211)-----A- Protein of unknown function DUF104EMF--A- Integral membrane protein DUF106----BA- NfeD-likeEM--BA- Domain of unknown function DUF108----BA- 3-dehydroquinate synthase (EC 4.6.1.3)E-F-BA- ArgJ familyEM---A- TraB family----BA- ThiC familyEMF-BA- DJ-1/PfpI familyEMF-BAV HD domainEM-PBA- MoaC familyEMFPBA- Hydantoinase/oxoprolinase----BA- Protein of unknown function DUF111----BA- Tripartite tricarboxylate transporter TctA family----BA- Serine dehydrogenase proteinase----BA- Protein of unknown function DUF115EMFP-A- tRNA intron endonuclease, catalytic C-terminal domainE-F-BA- Survival protein SurE----BA- Sugar-specific transcriptional regulator TrmBEMFPBA- Amidohydrolase familyEM--BA- Uncharacterised protein family UPF0066

Sheet1

EMF--AV Peptidyl-tRNA hydrolase PTH2-----A- Domain of unknown function DUF120-----A- Guanylyl transferase CofC likeEMF--A- Double-stranded DNA-binding domainE--PBA- CRS1 / YhbY (CRM) domainE-F-B-- Protein of unknown function DUF124E-FP-A- VIT family-----A- Protein of unknown function DUF126EMFPBA- ATP synthase (F/14-kDa) subunitEMFPBA- ATP synthase (E/31 kDa) subunitEMFPBA- ATP synthase (C/AC39) subunit-----A- methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase----BA- F420-0:Gamma-glutamyl ligaseEMF--A- Translin family-----A- Protein of unknown function DUF131----BA- Protein of unknown function DUF134EMF--A- TFIIE alpha subunitEMFPBA- N2,N2-dimethylguanosine tRNA methyltransferase-----A- Tetrahydromethanopterin S-methyltransferase MtrH subunitEM----- CXXC zinc finger domain

Rifin/stevor familyEM----- REJ domainEMFPB-- BNR/Asp-box repeatEM----- Reeler domainEMF-B-- Glycosyl hydrolase family 45----B-- LD-carboxypeptidaseEM----- CIDE-N domain----B-- Carbohydrate binding domainEM----- WIF domainEMFP--- eIF4-gamma/eIF5/eIF2-epsilon----B-- Uncharacterised protein family UPF0102EM----V Integrase Zinc binding domainEM----- SCAN domainEM----- Interleukin 5EM----- RyR domainE--PB-- RolB/RolC glucosidase familyEM----- Caldesmon----B-- Hypothetical lipoprotein (MG045 family)----B-- Streptomyces extracellular neutral proteinase (M7) familyEM-PB-- Ribosome-binding factor AEM----- CoagulinEMF-B-- SCP-2 sterol transfer familyEMFP--- SAP domainEM----- ATP1G1/PLM/MAT8 family----B-- Arsenical pump membrane protein

RWP-RK domain----B-- Bacteriochlorophyll C binding proteinEMFP--- CCAAT-binding transcription factor (CBF-B/NF-YA) subunit BEMF---- Cytochrome c oxidase subunit VIa----B-- Flagellar hook-basal body complex protein FliE----B-- Flagellar FliJ proteinEMF-B-- O-Glycosyl hydrolase family 30----B-- Family 4 glycosyl hydrolaseEM----- Glycosyl hydrolase family 59EM----- Guanylin precursorEM----- Slow voltage-gated potassium channel------V Lambda Phage CIII

Sheet1

EM----- MARCKS familyEMF---- MAS20 protein import receptorEMFPB-- MelibiaseE-F---- Metallothionein family 11EM----- Metallothionein family 5E--P--- Plant PEC family metallothionein----B-- Prokaryotic metallothioneinEM----- Neuromedin UEM-P--- Aromatic-di-Alanine (AdAR) repeat EM----- Prepro-orexin----B-- Thermophilic metalloprotease (M29)----B-- Crossover junction endodeoxyribonuclease RuvCE-F---- Pheromone A receptorEMF---- SURF4 familyEM----- Synapsin, N-terminal domainEM----- Nuclear transition protein 1E--PBA- TrkA-C domain----B-- Tryptophan RNA-binding attenuator protein----BA- Transcriptional regulatorEM----- Bindin----B-- Class III cytochrome C family----BAV D12 class N6 adenine-specific DNA methyltransferaseEM----- NitrophorinEMF---- Palmitoyl protein thioesterase----B-- Salmonella surface presentation of antigen gene type M proteinE--PB-- Glycyl-tRNA synthetase alpha subunitE--PB-- Glycyl-tRNA synthetase beta subunitEM----V Gag P30 core shell proteinEMFPB-- 60Kd inner membrane protein------V Filoviridae VP35EM----- Tick histamine binding proteinEM-P--- JosephinEMF---- Ornithine decarboxylase antizymeEM----- Ocular albinism type 1 proteinEMF-B-- SURF1 familyEM----- Fanconi anaemia group C protein----B-- Flagellar L-ring protein----B-- Flagellar assembly protein FliHEMFP--- DAD familyE-F-BA- Hydroxyethylthiazole kinase familyE-F-B-- cAMP phosphodiesterases class-II----B-- D-Ala-D-Ala carboxypeptidase 3 (S13) familyEMF---- PhosducinEMFP--- RHO protein GDP dissociation inhibitorEM----- Srg family chemoreceptor----B-- Flagellar P-ring protein----B-- Flagellar hook-length control protein FliKEM----- Phosphatidylinositol transfer protein------V Peptidase S39------V Viral RNA-directed RNA-polymerase------V Marek's disease glycoprotein AEM--B-- Phosphotriesterase familyEMF-B-- Aminopeptidase I zinc metalloprotease (M18)----B-- X-Pro dipeptidyl-peptidase (S15 family)EM--B-- Uncharacterized protein family UPF0054----B-- RecR proteinEMFP--- Repeat in ubiquitin-activating (UBA) protein

Sheet1

EM-P--- TAZ zinc fingerEMFPB-- Nuclear transport factor 2 (NTF2) domainEMF---- Adenosine-deaminase (editase) domainEMF---- Beige/BEACH domainEM-P--- Galactose binding lectin domainEMF---- DENN (AEX-3) domainEMF-BA- MGS-like domainEMF---- Repair protein Rad1/Rec1/Rad17EMF---- Rap/ran-GAPEMF-BA- Sir2 familyEMFP--- Zn-finger in ubiquitin-hydrolases and other proteinEMFP--- Kinase associated domain 1EMF--A- RNA polymerases M/15 Kd subunitE--PBA- UvrB/uvrC motifE-FPB-- Dihydroneopterin aldolaseE-FPBA- Prephenate dehydrogenase----B-- Flagellar motor switch protein FliMEM----- Glucocorticoid receptorE-F-B-- Glycosyl hydrolase family 26EMF---- Cation-dependent mannose-6-phosphate receptorEM----- Neuregulin familyEM----- Oestrogen receptorEM----- Progesterone receptorEM--BA- Peptidase family M50EM----- Wilm's tumour proteinEM----- Androgen receptorEMFPB-- Cytochrome C1 family----B-- LPP20 lipoprotein precursorEMFP--- PAZ domainEMFP-A- Piwi domainEM----- KIX domainEM----- pKID domainEM----- PTB domain (IRS-1 type)EM----- Serpentine type 7TM GPCR chemoreceptor SrbEM----- TRAF-type zinc fingerEM----- Amyloid A4 extracellular domainEM--B-- AT hook motifEMF---- BAG domainEMFP--- Formin Homology 2 DomainEM-P--- YDG/SRA domainE--P--- Homeobox associated leucine zipperEMF---- HAT (Half-A-TPR) repeatEMF---- Hr1 repeatEMF---- TFIIE beta subunit core domainEM----- Growth-Arrest-Specific Protein 2 DomainEM----- GoLoco motifEM----- Immunoreceptor tyrosine-based activation motifEMFPB-- ATP-dependent protease La (LON) domainEM----- Olfactomedin-like domainEM----- PI3-kinase family, p85-binding domainEMF---- PXA domainEMF-BA- ParB-like nuclease domainEM----- Raf-like Ras-binding domainEMF---- Regulatory subunit of type II PKA R-subunitEM----V Sterile alpha motif (SAM)/Pointed domainEM----- Saposin A-type domainE-F---- STE like transcription factor

Sheet1

EMFP--V SWIB/MDM2 domainEM----- Tachykinin family----B-- Tar ligand binding domain homologueEMF---- Vacuolar sorting protein 9 (VPS9) domainEMF---V WH2 motifEM----- Domain of unknown functionEMF---- Putative zinc finger in N-recognin (UBR box)EM----- Sorbin homologous domainEM-P--- Villin headpiece domainEM--B-- Laminin G domain----B-- Nitrile hydratase beta subunitEMFP--- Dynamin GTPase effector domainEMFP--- GYF domainEMF---V K+ channel tetramerisation domain------V Origin of replication binding proteinEM----- Repeat in HS1/CortactinEMFPB-- Methylenetetrahydrofolate reductaseEMF---- ML domainE-FPBA- ATP-grasp domainEMF-BAV Thymidylate kinase----BA- Cytidylate kinaseEMFPB-- PA domain------V Picornavirus coat protein (VP4)------V Major core protein p19EMFP--- Transcriptional Coactivator p15 (PC4)EMF-B-V Phospholipase/CarboxylesteraseEM--B-- NAD(P) transhydrogenase beta subunitEM-P--- Cyclin-dependent kinase inhibitorEMF-BA- Biotin protein ligase C terminal domainEM----- Cytochrome c oxidase subunit VIIa----B-- Cytochrome D1 heme domain-----A- Methyl-coenzyme M reductase gamma subunitEM----- Carboxypeptidase activation peptideEMFPBA- Methylpurine-DNA glycosylase (MPG)------V Large coat protein------V Small coat protein-----A- Methyl-coenzyme M reductase alpha subunit, C-terminal domain------V 35kD major secreted virus protein EM----- Proteasome activator pa28 alpha subunitEM----- Proteasome activator pa28 beta subunitEM--BA- TrkA-N domain----B-- PTS system, Lactose/Cellobiose specific IIA subunitEM--B-- Iron hydrogenase small subunitEMF---- RFX DNA-binding domain----B-V Shiga-like toxin beta subunitEMFP--- FAT domainEMFP--- FATC domain----BA- Aspartate decarboxylaseEM----V CBL proto-oncogene N-terminal domain 1EM----- Guanylate-binding protein, N-terminal domainE-F---- S1/P1 NucleaseEMFP--- Transcription initiation factor IIA, gamma subunit, helical domainEMF---- Transcription initiation factor IID, 18kD subunitEMF---- Transcription initiation factor IIF, beta subunitEMFP--- Ubiquinol-cytochrome C reductase complex 14kD subunitEMFPBA- DHHA1 domain----B-- Acyl transferase

Sheet1

EM--BA- Amidinotransferase----B-- Photosynthetic reaction centre cytochrome C subunit----BA- Phosphoribosyltransferase----B-- Transposase Tn5 dimerisation domain----B-- Cobinamide kinase / cobinamide phosphate guanyltransferaseEMF---- Cytochrome c oxidase subunit VaEM----- Cytochrome oxidase c subunit VIII

Dehydratase small subunit----BA- Cyclohydrolase (MCH)EMFP--- Signal recognition particle 14kD proteinEMF---- Transcription initiation factor IID, 31kD subunit----B-- AmiS/UreI family transporterEM----V Adenosine deaminase z-alpha domainEMF---- Alpha adaptin AP2, C-terminal domainEMF---- Cytochrome oxidase c subunit VIbE--P--- Plastocyanin-like domain----B-- Fumarate reductase subunit CEMFP--- HORMA domain----BA- PTS system, Lactose/Cellobiose specific IIB subunit----B-V Helix-destabilising protein------V Scaffold protein B----B-- MgtC familyE--P--- AUX/IAA familyEM--BA- B12 binding domain----B-- AraC-like ligand binding domainEM----- Core binding factor beta subunit----B-- Fumarate reductase subunit D----B-V Mu DNA-binding domain----B-- NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domainEM----- Rabphilin-3A effector domain N-terminalEM----- E2F/DP family winged-helix DNA-binding domainEMFP--- Ubiquinol-cytochrome C reductase hinge protein----B-- Outer membrane efflux protein----B-- Cytochrome oxidase subunit IIEM----- Egg-laying hormone precursor E---B-- YGGT familyE--P--- Plant ATP synthase F0----B-- Bacteriochlorophyll A protein----B-- Histidine carboxylase PI chainEMFP--- Mitochondrial glycoprotein------V Apoptosis preventing protein----B-- Replication terminator protein------V Capsid protein VP4EM----V Retroviral GAG p10 proteinEMF---V OTU-like cysteine protease

RbcX proteinE---B-- Bacterial stress protein

TRA-1 regulated protein R03H10.4EM----V Myc leucine zipper domain------V Chordopoxvirus fusion proteinEMFPBA- Glycine cleavage system P-proteinEM--BA- Cytidylyltransferase

Major surface glycoproteinEM--BA- UDP-N-acetylglucosamine 2-epimeraseEM----- GDNF/GAS1 domain----B-- Decorin binding protein----B-- Cyclopropane-fatty-acyl-phospholipid synthase

Sheet1

EM----- Latrophilin Cytoplasmic C-terminal region----BA- Protein export membrane protein----B-- Transcription termination factor nusGE-FPB-- Trehalose-phosphataseEMFP-A- Cell division protein 48 (CDC48), N-terminal domainE--PBA- Cobalt transport protein

Cysteine rich repeatE-FP--- 1,3-beta-glucan synthase component E--P--- No apical meristem (NAM) proteinEMF-B-- Dolichyl-phosphate-mannose-protein mannosyltransferase ----B-- Uncharacterised P-loop hydrolase UPF0079EM--B-V Bacterial Ig-like domain (group 2)----B-- Bacterial Ig-like domain (group 1)----B-- M protein repeat----B-- Transposase IS116/IS110/IS902 familyEM----- Interleukin 15EMFP--- JmjC domainEMFPBA- Anion-transporting ATPaseEMF---- jmjN domainEM----- CUT domainEM----- Dishevelled specific domain------V T-antigen specific domain----B-- MraZ protein----B-- RTX N-terminal domainEMF---- SacI homology domain----BAV N-6 DNA MethylaseE-FPBA- Cation transport protein----B-- IncFII RepA protein family----B-- FemAB familyEM----- Cornifin (SPRR) familyEMFPBA- Putative methyltransferase EMFPBA- MoaE proteinE--PB-- Ycf4------V US22 likeEM----- Interleukin-1 propeptide----B-- Immunoglobulin A1 protease------V Origin of replication binding protein----B-- Lysis proteinEMFPBA- Seryl-tRNA synthetase N-terminal domainEM----- Stem cell factorE--PB-- Domain of unknown function DUF140----B-- MmoB/DmpM family ------V Putative viral replication protein

CUB-like domainEMFPB-- Domain of unknown function DUF143----B-- MerT mercuric transport proteinEM----- Thrombospondin type 3 repeat----B-V Caudovirales tail fibre assembly protein----B-- Chlamydia polymorphic membrane protein (Chlamydia_PMP)----B-- mttA/Hcf106 family----BA- Chromate transporterE--PB-- PsbL protein----BA- Ferrous iron transport protein BEM----- KeratinEMF-B-- Ornithine cyclodeaminase/mu-crystallin familyEM----- Paralytic/GBP/PSP peptide----B-- Muconolactone delta-isomerase

Sheet1

E--PB-- Photosystem I reaction centre subunit IV / PsaEE------ Peridinin-chlorophyll A binding proteinE------ Apical membrane antigen 1

Cytochrome C oxidase, mono-heme subunit/FixOEM----- Fringe-like----B-- Levansucrase/InvertaseEMF-BA- Conserved carboxylase domainEM----V SKI/SNO/DAC familyEM----V Adenovirus E3 region protein CR2------V Adenovirus E3 region protein CR1EMFPBA- Flavoprotein------V Lipid membrane protein of large eukaryotic DNA viruses------V Circovirus capsid proteinE---BA- Quinolinate synthetase A proteinE--PB-- 4-alpha-glucanotransferase

L71 family----B-- Beta-galactosidaseEMF---- Lecithin:cholesterol acyltransferaseE--P--- Nodulin----B-- PemK-like proteinEMFP--- Reticulon------V Sigma 1s protein------V Hexon-associated protein (IIIa)------V Adenovirus IVa2 protein----BA- DisA bacterial checkpoint controller nucleotide-bindingE-FP--- Transferase family------V Adenoviral DNA terminal proteinEMF---- Patched family----B-- Ammonia monooxygenaseEMFPBAV RecF/RecN/SMC N terminal domain----B-- Competence-damaged protein----B-- Flagellar hook-associated protein 2 C-terminusEMFP--- Tim17/Tim22/Tim23 familyE--PB-- Photosystem II reaction centre N protein (psbN)EMFPB-- Fasciclin domainE--PB-- mce related protein

Borrelia outer surface protein E----B-- Biopolymer transport protein ExbD/TolR----B-- Nodulation protein A (NodA)EMFP-A- Met-10+ like-protein------V US2 family------V Pneumovirus phosphoprotein------V Herpesvirus immediate early proteinEM----V Alphaherpesvirus glycoprotein E----B-- DNA recombination-mediator protein AE--PB-- Sigma 54 modulation protein / S30EA ribosomal proteinEM----V Core-2/I-Branching enzymeEM--B-- Replication initiation factorEMF---- CLN3 protein

Merozoite Antigen------V Herpesvirus glycoprotein H----B-- Cell division protein FtsAEMF-BA- CobW/HypB/UreG, nucleotide-binding domainEM-P--- MORN repeatEM----- HYR domain------V 7kD viral coat proteinE--P--- ABA/WDS induced protein

Sheet1

----B-V BRO family, N-terminal domainE--PB-- Ribose/Galactose Isomerase----B-- Fatty acid synthesis protein-----A- Methyl-coenzyme M reductase operon protein DE--PB-- Photosystem I reaction centre subunit III------V Rotavirus non-structural protein 35----B-- Surface presentation of antigens proteinE---BAV Thymidylate synthase complementing proteinEM----- Spin/Ssty Family----BA- CobN/Magnesium ChelataseEM--B-- CoA-transferase family IIIEMF--A- Oligosaccharyl transferase STT3 subunitEMFPB-- CAAX amino terminal protease familyEMFPBAV Histidine kinase-, DNA gyrase B-, and HSP90-like ATPaseE--P--- Auxin responsive proteinEM----- Domain of unknown function DUF148

Putative outer membrane protein----B-- Aminoglycoside 3-N-acetyltransferase

KID repeatEMF-B-- Flavodoxin-like foldE------ Glycophorin-binding proteinEM--B-- rRNA small subunit methyltransferase GE--PB-- Cytochrome B6-F complex subunit 5E--PB-- PsaDE--PB-- Photosystem II 4 kDa reaction centre component----B-- TraG/TraD familyEMFPBA- ZIP Zinc transporterEM----- mTERFE-F-BA- CrcB-like proteinEMFPBA- Hydantoinase B/oxoprolinaseEMF-BA- NAD synthaseE-F-B-- Ppx/GppA phosphatase familyE--PB-- YgbB familyEMFP--- 3-oxo-5-alpha-steroid 4-dehydrogenase EMF-BA- Maf-like protein----B-- Queuosine biosynthesis proteinE-F-B-- Acetyl-CoA hydrolase/transferase N-terminal domainEMF-B-- Acyl-CoA thioesterase-----A- CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit----BA- Cobalt transport protein component CbiN----B-- Carbon starvation protein CstA----BA- Preprotein translocase subunit SecBE-F-BA- Ketopantoate reductase PanE/ApbA----B-- CarD-like/TRCF domain----B-- Flagellar protein FliS----B-V PhoH-like protein----B-- Polysaccharide biosynthesis/export proteinE---B-- Recombination protein O C terminal----BA- OsmC-like proteinEMF-B-- Phenazine biosynthesis-like protein----BA- Thiamine biosynthesis protein (ThiI)E-FPB-- Pantoate-beta-alanine ligase----BA- Precorrin-8X methylmutase----BA- Precorrin-6x reductase CbiJ/CobK----B-- ATP:corrinoid adenosyltransferase BtuR/CobO/CobPEMFPB-- Homocysteine S-methyltransferase----B-- Uncharacterised BCR, YbaB family COG0718

Sheet1

----B-- Uncharacterised BCR, YhbC family COG0779EM--B-- Multi-copper polyphenol oxidoreductase laccaseEMF-BA- D-Tyr-tRNA(Tyr) deacylaseE-F-BA- Thiamine monophosphate synthase/TENIEMF---- Uncharacterised ACR, YagE family COG1723----B-- Uncharacterised BCR, COG1937EMF-B-V GlcNAc-PI de-N-acetylaseEMF-B-V Uncharacterised ACR, COG2135----B-- Uncharacterised ACR, YkgG family COG1556E--PBA- Predicted SPOUT methyltransferase----B-- Putative zinc ribbon domain----B-- Uncharacterized ACR, YhhQ family COG1738-----A- Uncharacterized ArCR, COG1810EM--BA- Uncharacterised ACR, YggU family COG1872----B-- Glycerate kinase family-----A- Uncharacterised ArCR, COG2043EMFPBA- ThiS familyEMF--A- Uncharacterized ACR, COG2106----B-- Global regulator protein family----B-- Exonuclease VII, large subunitEMFPBA- Uroporphyrinogen-III synthase HemD----B-- HPr Serine kinase N terminus----B-V Phd_YefME--PB-- Photosystem I reaction centre subunit XI----B-- Tetraacyldisaccharide-1-P 4'-kinaseEM--BA- B12 binding domain----B-- Exonuclease VII small subunit----B-- L-arabinose isomerase----B-- CDP-diacylglycerol pyrophosphatase----BA- Malate/L-lactate dehydrogenase----BA- ScpA/B proteinEMF-B-- ATP-dependent Clp protease adaptor protein ClpS----B-- YceG-like family----B-- Uncharacterized ACR, COG1399----B-- FliW protein----BA- YcaO-like family----B-- XdhC and CoxI familyE-F-B-- Allophanate hydrolase subunit 2E-F-BA- Carboxymuconolactone decarboxylase familyEMF-BA- Cytochrome oxidase assembly proteinEMFPBA- CoA binding domainEMF-B-- SCO1/SenC----B-- RecX familyE---BA- BioY family----BA- DsrE/DsrF-like familyEMF---- Uncharacterized ACR, COG1565EMF-BA- GatB domain----B-- Uncharacterised BCR, COG1649----B-- Uncharacterized BCR, YaiI/YqxD family COG1671----BA- Uncharacterized ACR, COG1993-----A- Uncharacterized ACR, COG1430----B-- RmuC family----BA- Sporulation Regulator WhiA C terminal domain----BA- Branched-chain amino acid transport system / permease componentEM--BA- ATP-grasp domainE-F-B-- Domain of unknown function DUFE--PB-- Fe-S metabolism associated domain

Sheet1

----BA- Domain of unknown function DUFEM--B-V Fic/DOC family-----A- Methyl-viologen-reducing hydrogenase, delta subunit-----A- FmdE, Molybdenum formylmethanofuran dehydrogenase operon ----B-- S-Ribosylhomocysteinase (LuxS)----BA- Nitrate reductase gamma subunitEMF-BA- Phosphatidylserine decarboxylase----B-- Short chain fatty acid transporterEMFPB-- Taurine catabolism dioxygenase TauD, TfdA family----BA- K+-transporting ATPase, c chainE--PB-- 1-deoxy-D-xylulose 5-phosphate reductoisomeraseEMFP--- Paired amphipathic helix repeatE--P--- CP12 domain----B-- Colicin V production protein----B-- Uncharacterized BCR, COG1636----BA- (2R)-phospho-3-sulfolactate synthase (ComA)-----A- Uncharacterized ArCR, COG1888E-F-B-- Allophanate hydrolase subunit 1----B-- Lipid-A-disaccharide synthetaseEM--BA- Glu-tRNAGln amidotransferase C subunit----BA- Predicted permeaseEM----V HelicaseEM--B-- Na+/Pi-cotransporter----B-- Vacuolating cyotoxin----BA- Uncharacterised BCR, YnfA/UPF0060 familyEMF-B-- Uncharacterized ACR, YdiU/UPF0061 family-----A- Uncharacterized ACR, COG1753----B-- DUF218 domain----B-- Preprotein translocase subunit----BA- Phosphoribosylformylglycinamidine (FGAM) synthaseE--P--- Dof domain, zinc finger----B-- Osmosensitive K+ channel His kinase sensor domain------V Early E1A proteinE--P--- Gibberellin regulated proteinE-FPBA- K+ potassium transporter----B-- Chain length determinant proteinEM----- Galactosyltransferase------V E4 proteinEMF---- Domain of unknown function DUF221------V Herpesvirus UL31-like protein----BA- Polysaccharide biosynthesis protein----B-- Domain of unknown function DUF222

Domain of unknown function DUF223------V Non-structural protein NS3/Small envelope protein EEMF---- CDC45-like protein------V Non-structural protein CEMFPBA- Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain----BA- Aldehyde ferredoxin oxidoreductase, N-terminal domainEMF---- SKIP/SNW domainEMFP-A- ERCC4 domainEMFPB-- Dak1 domainEMFPB-- DAK2 domainEMF---- Ku70/Ku80 beta-barrel domainEMF---- Myosin N-terminal SH3-like domainEMFPB-- 3-hydroxyacyl-CoA dehydrogenase, NAD binding domainEMFPB-- Molybdopterin-binding domain of aldehyde dehydrogenase----B-V 5'-3' exonuclease, N-terminal resolvase-like domain

Sheet1

----BA- FTR, proximal lobe----BA- Iron dependent repressor, metal binding and dimerisation domainEM--B-- Cache domainEMF-B-- Galactose-1-phosphate uridyl transferase, C-terminal domain-----A- Methyl-coenzyme M reductase alpha subunit, N-terminal domainEM--BA- Mandelate racemase / muconate lactonizing enzyme, N-terminal domainEMFP-AV Proliferating cell nuclear antigen, C-terminal domain----BA- Aspartate carbamoyltransferase regulatory chain, metal binding domainEMF-BA- Quinolinate phosphoribosyl transferase, N-terminal domainEM----- Synapsin, ATP binding domainEMFP--- Transcription initiation factor IIA, gamma subunitEMF---- Arrestin (or S-antigen), C-terminal domain----BA- Cysteine-rich domainEM----- RPEL repeat

GYR motifYLP motif

EM----- PAAD/DAPIN/Pyrin domainEM----- RUN domainEM----V CBL proto-oncogene N-terminus, EF hand-like domainEM----V CBL proto-oncogene N-terminus, SH2-like domain------V Diphtheria toxin, T domainEMF---- Telomeric single stranded DNA binding POT1/CDC13----B-- DNA polymerase III beta subunit, central domainEMFPBAV AIR synthase related protein, C-terminal domainEMFPB-- Acyl-CoA dehydrogenase, middle domainEM-PB-- Acyl-CoA dehydrogenase, N-terminal domainEMFPB-- S-adenosylmethionine synthetase, central domainEMFPB-- S-adenosylmethionine synthetase, C-terminal domainE-FPBA- Semialdehyde dehydrogenase, dimerisation domainEMFPBA- Thiamine pyrophosphate enzyme, C-terminal TPP binding domainEMFPBA- Thiamine pyrophosphate enzyme, N-terminal TPP binding domainEMFPBA- Iron/manganese superoxide dismutases, C-terminal domainEM-P-A- tRNA intron endonuclease, N-terminal domainEMFPBA- Transketolase, pyrimidine binding domainEMFPBA- Transketolase, C-terminal domainEMFPB-- Glucose-6-phosphate dehydrogenase, C-terminal domainEMF-BA- FGGY family of carbohydrate kinases, C-terminal domainEMFPBA- Pyridoxal-dependent decarboxylase, pyridoxal binding domainEMFPBA- Biotin carboxylase C-terminal domainEMFPBA- Carbamoyl-phosphate synthase L chain, ATP binding domainEMF-BA- Carbamoyl-phosphate synthetase large chain, oligomerisation domainE--PBA- Ribulose bisphosphate carboxylase large chain, N-terminal domainEMFPBA- Cytosol aminopeptidase family, N-terminal domainEMFPB-- Cytochrome C oxidase subunit II, transmembrane domainEMF---- DDT domainEMFP--- Mago nashi proteinEM----- Hormone receptor domain----B-- RTX toxin acyltransferase family----BAV Helix-turn-helix domain of resolvaseE--PB-- Chalcone and stilbene synthases, C-terminal domainEMFPB-- Glutathione S-transferase, N-terminal domainEMFP--V Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domainEMFPBA- Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domainEMFPB-- Beta-ketoacyl synthase, C-terminal domainEMFPBA- Thiolase, C-terminal domain----B-- Metal binding domain of AdaEMFPBA- Alpha amylase, C-terminal all-beta domain

Sheet1

EM----- ATP:guanido phosphotransferase, N-terminal domainEMFP--- Ubiquitin interaction motifEMFPBA- Glu/Leu/Phe/Val dehydrogenase, dimerisation domainEMFP--- MIR domainEM----- Alpha-kinase familyEMFPB-- e3 binding domainEM----- PPAK motifEM----- mbt repeat----B-V Staphylokinase/Streptokinase familyEM----- Antistasin familyEMFPB-- ATP synthase, Delta/Epsilon chain, beta-sandwich domainEMFPBA- TGS domainEM----- WWE domainEMFPBA- D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domainEM----- cAMP-dependent protein kinase inhibitorEM----- L27 domain----BA- 3H domain----B-V gpWEMF-BA- DHHA2 domain----BA- 2',5' RNA ligase familyEMFPB-- Glycosyl hydrolases family 2, TIM barrel domainEMFPB-- Glycosyl hydrolases family 2, sugar binding domainEMF-B-- Glycosyl hydrolase family 20, domain 2----B-- Carbohydrate binding domainEMF---- Prp18 domainEM----- Guanylate-binding protein, C-terminal domainEMFPBA- Phosphoribosylglycinamide synthetase, C domainEMFPBA- Phosphoribosylglycinamide synthetase, N domainEMF---- CUE domainEMFP--- MA3 domainEMFPBA- Pyridine nucleotide-disulphide oxidoreductase, dimerisation domainEMFP--- MIF4G domainE-FPB-- Clp amino terminal domainEMF---- DDHD domain----B-- Arginine repressor, C-terminal domainEM----- STAT protein, DNA binding domainEM----- STAT protein, protein interaction domainEMFPBA- lactate/malate dehydrogenase, alpha/beta C-terminal domainEMFPB-V Ribonucleotide reductase, barrel domain----B-- Thermolysin metallopeptidase, alpha-helical domainEM--B-- 5'-nucleotidase, C-terminal domain----B-- UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domainEMFPBA- ATP synthase alpha/beta family, beta-barrel domainEM--B-- Mur ligase family, glutamate ligase domain----B-- Staphylococcal/Streptococcal toxin, beta-grasp domainEM-P--- Poly(ADP-ribose) polymerase, regulatory domainEMFPBA- Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain IEMFPBA- Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain IIEMFPBA- Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain IIIEMFPBA- SRP54-type protein, helical bundle domainEMF-BA- Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domainEMF---- Adaptin C-terminal domain----B-- Polysaccharide lyase family 8, C-terminal beta-sandwich domainEMFPBA- Glycosyl transferase family, helical bundle domainEMFPBA- Pyruvate kinase, alpha/beta domainEM----- Calmodulin binding domainEMF--A- Sec63 Brl domain

Sheet1

Borrelia family of unknown function DUF226EMFP--- MIZ/SP-RING zinc fingerEMF---- BED zinc fingerEMFP--- GRAM domainEMFPB-- Oxidoreductase family, C-terminal alpha/beta domain----B-- Signal transducing histidine kinase, homodimeric domainEM--B-- Prolyl oligopeptidase, N-terminal beta-propeller domainEM--B-- Nitric oxide synthase, oxygenase domain----BAV Phage integrase, N-terminal SAM-like domainE-FPB-- Catalytic LigB subunit of aromatic ring-opening dioxygenaseE--PB-- Pyruvate formate lyaseEMF-B-V Ulp1 protease family, C-terminal catalytic domain------V Epstein Barr virus nuclear antigen-1, DNA-binding domainEMF-B-- Iron only hydrogenase large subunit, C-terminal domain------V Hepatitis C virus NS3 protease----B-- Tetracyclin repressor, C-terminal all-alpha domainEMFPBA- domainEMF-B-- Formyl transferase, C-terminal domain----B-- Aminoacyl tRNA synthetase class II, N-terminal domainEMF-B-- FAD linked oxidases, C-terminal domainE--PBA- Rubrerythrin----B-- Pertussis toxin, subunit 2 and 3, C-terminal domainEMFP--- Eukaryotic DNA topoisomerase I, DNA binding fragmentEM--B-- DNA binding domain of tn916 integraseEMFP--- Ubiquinol cytochrome reductase transmembrane regionEMFPBA- Carbohydrate-binding module 48 (Isoamylase N-terminal domain)------V Bacteriophage scaffolding protein DEMF-BA- THUMP domain----B-- N-terminal ig-like domain of cellulaseEMF---- C5HC2 zinc fingerEM--B-- Neurotransmitter-gated ion-channel ligand binding domainEM----- Neurotransmitter-gated ion-channel transmembrane regionEMFP-A- Cell division protein 48 (CDC48), domain 2EMF-BA- GatB/GatE catalytic domainEMF---- Cytochrome c oxidase subunit VIIcEMF---- Cytochrome c oxidase subunit IVEM----- Cytochrome c oxidase subunit VIcEM--BA- GAD domainEMF---- UcrQ familyE-F---V mRNA capping enzyme, beta chainE--PB-- Ferredoxin thioredoxin reductase variable alpha chain------V Influenza B non-structural protein (NS1)EM----- BESS motif------V Recombination endonuclease VIIEM----- flt3 ligand EM----- AmelogeninEM----- 7tm Odorant receptorEM----- ConotoxinEMFP--V Tim10/DDP family zinc finger----BA- Bacterial regulatory protein, Fis family------V TT viral orf 1------V TT viral ORF2

Domain of unknown function (DUF227)------V HTLV Tax

K1 glycoproteinEM----- Barrier to autointegration factor----B-- Methane monooxygenase, hydrolase gamma chain

Sheet1

EM--B-- Vitamin B12 dependent methionine synthase, activation domainEMF---- Mitosis protein DIM1EMF---- TATA box binding protein associated factor (TAF)EMFP--- Tubulin binding cofactor AEM--B-- Sialidase, N-terminal domain----B-- Methylamine dehydrogenase, L chainE--P--- Carboxypeptidase A inhibitorEMFPBA- Signal peptide binding domain----B-- Restriction endonuclease FokI, recognition domainE-F---- Scytalone dehydratase----B-- Alpha-lytic protease prodomainEMFP--- Cyclin, C-terminal domainEMFPB-- HEAT repeat----B-- Fibronectin binding repeatEM-PB-- Late embryogenesis abundant proteinEM----- Phospholipase A2 inhibitor

Lyme disease proteins of unknown functionEMF---- Endomembrane protein 70EMFP--- Microtubule associated protein 1A/1B, light chain 3

Transposase family tnp2------V Minor capsid protein VIEM----- L1 transposable element

Protein of unknown function (DUF229)EMFPBA- Prefoldin subunit------V Lentiviral Tat protein

Borrelia orf-D familyE--P--- Plant transposase (Ptta/En/Spm family)

Arabidopsis proteins of unknown functionEMF-B-- Haemolysin-III relatedE--PB-- Uncharacterised protein family (UPF0089)-----A- Archaea bacterial proteins of unknown functionEMFPB-- Glycerophosphoryl diester phosphodiesterase family

PFEMP DBL domain------V Pyrimidine dimer DNA glycosylase------V Structural protein 2EM-P--- Male sterility proteinEM-P--- Exostosin family

TNP1/EN/SPM transposaseEM----- LEM domain------V Influenza C virus M2 proteinEM----- Major royal jelly protein----B-- MviN-like proteinEM-P--- Folate receptor family------V Papillomavirus E5------V Influenza C virus M1 proteinEMFP--- Dynein heavy chainEMF---- Conserved hypothetical ATP binding proteinEMFP--V NLI interacting factor-like phosphataseEM----- Brevenin/esculentin/gaegurin/rugosin familyE-F-BA- Glycosyltransferase family 28 N-terminal domainEM----- Phosphatidyl serine synthase------V Calicivirus putative RNA polymerase/capsid proteinEM----- Perilipin familyE------ Kinetoplastid membrane protein 11E--PB-- CemA family------V lef-2------V Herpesvirus UL87 family

Sheet1

EM----- DAN domain----B-- COMC familyE--P--V UL92 family------V UL79 family----B-- Transposase IS66 family EMF-B-- Peptidase C1-like family------V Adenoviral protein L1 52/55-kDaEMF-B-- tRNA methyl transferaseEM-P--- Retinal pigment epithelial membrane protein

Protein of unknown functionSar8.2 family

E--P--- Nicotianamine synthase proteinE-F-B-- 2-nitropropane dioxygenaseEMF-BA- Thioesterase superfamilyEMFPB-- MBOAT family----BA- Prismane/CO dehydrogenase family------V HSV U79 / HCMV P34EM-P--- Nucleoplasmin----B-V Chitin binding domainEM----- Protein-arginine deiminase (PAD)E-FPB-- TENA/THI-4/PQQC familyEM-P--- GNT-I family----B-- MG032/MG096/MG288 family 1EMF-B-- TspO/MBR familyEMF---- Glutamate-cysteine ligase------V Equine arteritis virus GP3

ATHILA ORF-1 familyEMFPB-- ARD/ARD' familyEMF---- Exo70 exocyst complex subunitEM----- Male accessory gland secretory proteinEM-P--- MtN3/saliva family

Rhoptry-associated protein 1 (RAP-1)----B-- MG032/MG096/MG288 family 2

Arabidopsis protein of unknown functionEM-P--- Strictosidine synthaseEM----- Recombination activating protein 2EM-PBA- CutA1 divalent ion tolerance protein

BT1 familyE--P--- Mlo familyEMF---- Phosphotyrosyl phosphate activator (PTPA) proteinEM-P--- Ndr familyEMF---- BRO1-like domainEMF---- Animal haem peroxidaseEMFPBA- Biotin/lipoate A/B protein ligase family----BA- CcmEE--P--- FAR1 DNA-binding domainEM--BA- NeuB family

Domain of unknown function (DUF243)EMFPBAV DNA polymerase family B, exonuclease domainEMFP--- SPX domain

C1 domainEMFPB-V ABC1 familyE--P--- SBP domain

Uncharacterized protein family (ORF7) DUFEMFP--- BAR domain------V Astrovirus capsid protein precursor------V UL49 family

Sheet1

E--PB-- Bacterial RNA polymerase, alpha chain C terminal domain----BA- NAD-dependent DNA ligase C4 zinc finger domain----BAV NAD-dependent DNA ligase OB-fold domainEM----V Herpesviridae UL52/UL70 DNA primase------V Herpes virus major capsid protein----B-- CAT RNA binding domainEMFP--- EXS familyEM----- C. elegans Sre G protein-coupled chemoreceptorEMFP--- Plus-3 domainEMF---- GAT domainEM----- CXCXC repeatEMFPBA- Anticodon binding domainEMFPB-- PBS lyase HEAT-like repeatEM----V bZIP Maf transcription factorEMF---- Tubulin-tyrosine ligase familyEMFP--- TB2/DP1, HVA22 family----B-- CagE, TrbE, VirB family, component of type IV transporter systemEM----- Organic Anion Transporter Polypeptide (OATP) family----B-- Vanadium/alternative nitrogenase delta subunit

Putative methyltransferaseEMF-B-- Chitin synthaseEMFPBAV Elongation factor Tu C-terminal domainEMFPBA- Elongation factor Tu domain 2EM-P--- Seven in absentia protein familyEMF-BA- Ferredoxin-fold anticodon binding domainEM----- Tektin family----B-- Di-haem cytochrome c peroxidaseEMFP--- Triose-phosphate Transporter familyEMF---- Ubiquitin fusion degradation protein UFD1EMF---- Transcription factor IIA, alpha/beta subunitEM----- Atrophin-1 familyEMFP--- ALG6, ALG8 glycosyltransferase family------V Multigene family 530 proteinEMFP--V XRN 5'-3' exonuclease N-terminusEM----- Calx-beta domainE-FP--- Tyrosine phosphatase familyEMF----EM----- MH1 domainEM----- MH2 domainEMF-B-V Uracil DNA glycosylase superfamilyE--P-A- Late embryogenesis abundant proteinE-FPB-- OPT oligopeptide transporter proteinEMFPB-V 2OG-Fe(II) oxygenase superfamilyEM----- Sp100 domain----B-- Putative carbohydrate binding domain----B-- Chitobiase/beta-hexosaminidase C-terminal domainE-FP--V DNA polymerase type B, organellar and viralEM--BA- MMPL familyEMF---- Non-repetitive/WGA-negative nucleoporin C-terminalEMFP--- CPSF A subunit regionEMFP--- Vacuolar (H+)-ATPase G subunit----B-- NLPA lipoproteinE--P--- BURP domain

Borrelia repeat proteinEMF---- DDE superfamily endonucleaseEM----- Calcium-activated potassium channel, beta subunit----BA- CobD/Cbib protein

Sheet1

------V Corona nucleocapsid I proteinEM----- Eukaryotic cytochrome b561EM----- Protein of unknown function, DUF270EM--BA- Protein of unknown function, DUF255

Pyrococcus protein of unknown function, DUF257E-F-BA- Protein of unknown function, DUF258EMF---- LUC7 N_terminusE--P--- Protein of unknown function DUF260

Protein of unknown function, DUF261E-F---- Glycolipid anchored surface protein (GAS1)EMFP--- Eukaryotic glutathione synthaseEMF---- Mannosyl oligosaccharide glucosidase-----A- H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase----B-- Putative mycoplasma lipoprotein, C-terminal region----B-- MerC mercury resistance proteinEMF-BA- Molybdopterin guanine dinucleotide synthesis protein B----B-- Nitrogen fixation protein NifW

Borrelia outer surface protein D (OspD)EMFP--- PRA1 family protein----B-- PUCC protein------V Paramyxovirus P/V phosphoprotein----B-- Pectate lyase------V Poxvirus P35 proteinE--P--- Reversibly glycosylated polypeptideEMFP--- Rad17 cell cycle checkpoint protein------V Rhabdovirus nucleoproteinE--PB-- TLC ATP/ADP transporter------V Tombusvirus P19 core proteinEMF---- Tc5 transposase DNA-binding domain----B-- Tryptophan/tyrosine permease familyEMFP--- V-ATPase subunit CEMFP--- V-ATPase subunit HEMFP--- Yippee putative zinc-binding proteinEM----- Gamma interferon inducible lysosomal thiol reductase (GILT)------V Adenoviral core protein VII------V Alphavirus glycoprotein J----B-- Antirestriction proteinEMF-B-- Ubiquinone biosynthesis protein COQ7------V Aphid transmission proteinEMF---- Cdc37 N terminal kinase binding-----A- Protein of unknown function DUF262----B-V Terminase-like familyE------ ESAG proteinE-F-BA- Iron permease FTR1 familyE--P--- Late embryogenesis abundant protein----B-V Bacteriophage lysis proteinEM----- Prothymosin/parathymosin familyEMFP--- Rer1 family----B-- Type specific antigenEM----- Tropomodulin------V Herpesvirus UL21EM----- Urea transporterE--P--- Xyloglucan fucosyltransferaseE---B-- Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunitEMFP--- Anaphase-promoting complex, subunit 10 (APC10)------V Baculovirus FP proteinEM--BA- Roadblock/LC7 domain

Sheet1

EM----- Cyclin-dependent kinase 5 activator protein------V Cucumovirus protein 2B----B-- NapC/NirT cytochrome c family, N-terminal regionEM--B-- Deoxyribonuclease IIEM--BA- Protein of unknown function, DUF265EMF---- EB1-like C-terminal motif------V Viral enhancin protein------V Baculovirus gp64 envelope glycoprotein family------V Foamy virus BEL 1/2 protein------V Spumavirus gag protein------V Herpesvirus UL4 family----B-- IpaB/EvcA family----B-- Proteobacterial lipase chaperone proteinEM----- Mab-21 proteinEM----- Pectinacetylesterase----B-- Phenazine biosynthesis protein A/BEM----- Paralemmin------V Pox virus Ag35 surface protein------V Poxvirus C7/F8A protein------V Poxvirus D5 protein-like------V Vaccinia virus I7 processing peptidaseEMFP--V mRNA capping enzyme------V Poxvirus P4B major core protein------V Poxvirus trans-activator protein A1 C-terminal------V Poxvirus poly(A) polymerase catalytic subunitEMFP-A- S25 ribosomal proteinEM----- Transcription factor AP-2------V Tenuivirus non-structural protein NS4EM--B-- Tryptophan 2,3-dioxygenaseE------ Giardia variant-specific surface proteinE-F---- WTF protein----B-- Mlp lipoprotein family----B-- Mycoplasma MG185/MG260 protein----B-- Alpha-acetolactate decarboxylase------V Adenovirus 15.3kD protein in E3 regionEM--BA- ArgK protein------V Caulimovirus DNA-binding proteinEMF---- Cornichon protein

Protein of unknown function (DUF272)----BA- Serine dehydratase alpha chain

Protein of unknown function, DUF273----B-- Serine dehydratase beta chain

ELF protein----B-- Ethanolamine utilisation protein EutN/carboxysome----B-- Bacterial fructose-1,6-bisphosphatase, glpX-encodedEM-P--- GH3 auxin-responsive promoter----B-- Bacillus/Clostridium GerA spore germination protein------V Herpesvirus polymerase accessory protein------V Herpesvirus transcription activation factor (transactivator)EM--B-- HpcH/HpaI aldolase/citrate lyase familyE--PB-- Rare lipoprotein A (RlpA)-like double-psi beta-barrelEMFP--- Eukaryotic phosphomannomutase----B-- Adhesin biosynthesis transcription regulatory protein----BA- Na+/H+ antiporter subunit------V Poxvirus C4/C10 protein------V Poxvirus J1 protein------V Poxvirus L3/FP4 protein

Sheet1

------V Poxvirus rifampicin resistance protein------V Poxvirus mRNA capping enzyme, small subunitEMF---- SART-1 familyEM----- Daxx FamilyEMF---- Oligosaccharyltransferase 48 kDa subunit beta----B-- Vibrio thermostable direct hemolysinEMF---- Serine incorporator (Serinc)----B-- Uncharacterized protein family, UPF0114EM----- DOMON domain----B-- Methyladenine glycosylaseEM----- Ras-mediated vulval-induction antagonist----B-V Phage Terminase ------V Viral Trans-Activator Protein ------V Viral late protein H2 EMFP--- Snf7E-FPBA- NADPH-dependent FMN reductaseEM----- Guanylate-kinase-associated protein (GKAP) proteinEM----- Glycosyltransferase family 43------V Herpes virus intermediate/early protein 2/3EMF-B-- Polyketide cyclase / dehydrase and lipid transportEMF---- YEATS familyEMF--A- ZPR1 zinc-finger domainEMFP--- Double stranded RNA binding domain------V Herpesvirus UL3 proteinEMF---- Putative phosphatase regulatory subunitEMF---- PRP38 familyEMFPB-V Endonuclease/Exonuclease/phosphatase family------V Phage antirepressor protein KilAC domain------V Adenovirus E3B proteinEMFP--- CAS/CSE protein, C-terminusE--PB-- CcmB proteinEMFP--- LEM3 (ligand-effect modulator 3) family / CDC50 family

Mycoplasma protein of unknown function, DUF285EM----- Caenorhabditis serpentine receptor-like protein, class xa

Drosophila protein of unknown function, DUF287Protein of unknown function, DUF288

------V Herpesvirus UL46 proteinEMF---- Legume-like lectin family----B-- MobA/MobL family----B-- 2-hydroxycarboxylate transporter family------V Nepovirus coat protein, central domainEM----- Insect pheromone-binding family, A10/OS-D------V Pneumovirus matrix protein------V Poxvirus E8 protein------V Poxvirus P4A protein------V Poxvirus DNA-directed RNA polymerase, 35 kD subunit------V Rhabdovirus matrix proteinEMF---- Regulator of Vps4 activity in the MVB pathwayEMFP--- SAC3/GANP/Nin1/mts3/eIF-3 p25 familyEM----- Vomeronasal organ pheromone receptor family, V1REMF---- isoform IIEMFP--- Mo-co oxidoreductase dimerisation domainE--P--- Fatty acid desaturase----B-V Phage tail fibre repeatE--PB-- Nucleotide-diphospho-sugar transferase------V Foamy virus envelope protein ----BAV Peptidase C39 family

Sheet1

----B-- Peptidase propeptide and YPEB domainEM----- Glycosyltransferase family 6EMFP--- Peptidase family C54E-F--A- Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase----B-- Germination protease----B-- Sporulation factor SpoIIGA E--PB-- Carbohydrate binding domain (family 25)----B-- Carbohydrate binding domain (family 11)

Carbohydrate binding domain (family 15)E-F---- Carbohydrate binding domain (family 19)----B-- Replication protein C N-terminal domain

Major surface protein 1B------V Trans-activating transcriptional regulator ------V RNA replicase, beta-chain ----B-- Relaxase/Mobilisation nuclease domain

EspA-like secreted protein DUF276

EMFPB-- Saccharopine dehydrogenase EM--BA- BtpA family------V Pneumovirus NS1 proteinEMFP-A- Early transcription elongation factor of RNA pol II, NGN section----B-- Aerolysin/Pertussis toxin (APT) domainEMFPBAV FAD binding domain of DNA photolyase----B-- Domain of unknown functionE-F---- Glycosyl hydrolase family 61----B-- Putative nucleotidyltransferase DUF294EMFPB-- NAD binding domain of 6-phosphogluconate dehydrogenaseEMFPBA- Homoserine dehydrogenase, NAD binding domain----B-- MgtE intracellular N domain----B-- domainEMFPB-- CO dehydrogenase flavoprotein C-terminal domainEM----- HELP motifEMF---- Anp1EM-PBA- MoeA N-terminal region (domain I and II)EM-PBA- MoeA C-terminal region (domain IV)EMF---- dDENN domainEMF---- uDENN domain

Helicase associated domain----BA- TOBE domain----B-- TRCF domainEMF-B-- PCRF domainEMFP-A- eRF1 domain 1EMFP-A- eRF1 domain 2EMFP-A- eRF1 domain 3E--PBA- LysR substrate binding domainEMF---- Smg-4/UPF3 familyE--P--- XS domain

XH domainE--P--- XS zinc finger domain----B-- Transporter associated domain----B-- Autoinducer binding domainEMFPB-- MOSC domainEM----- DMRTA motif----B-- 3-alpha domainEMFPB-- MOSC N-terminal beta barrel domainEMFPBAV ATP cone domainE--P--- Protein of unknown function (DUF295)

Sheet1

E--PB-- Domain of unknown function (DUF296)----B-- Bacterial extracellular solute-binding protein, family 7 E-F-B-- SUA5 domainEMFPBA- B3/4 domainEMFPBA- tRNA synthetase B5 domainEMF-BA- Arginyl tRNA synthetase N terminal domain----BA- HI0933-like proteinEM----- Interleukin-13EM----- Nematode insulin-related peptide beta typeEM-P--- Saposin-like type B, region 2E------ Variant-surface-glycoprotein phospholipase CEM----- Serotonin (5-HT) neurotransmitter transporter, N-terminusE--P--- SAM dependent carboxyl methyltransferaseEM----- Calcium-activated BK potassium channel alpha subunitEM----- Beta-amyloid peptide (beta-APP)----B-- Clostridial binary toxin B/anthrax toxin PA----B-V Clostridial binary toxin A----B-- Cytolethal distending toxin A/C family----B-- Cellulose synthase subunit DEMFP--- Plectin/S10 domain----B-- Nucleoside-specific channel-forming protein, Tsx----B-- Chlamydia cysteine-rich outer membrane protein 6------V Influenza C non-structural protein (NS1)EM----- Gap junction alpha-8 protein (Cx50)------V 2C endopeptidase (C24) cysteine protease familyEM----- Fanconi anaemia group A protein----B-- Glycosyl hydrolase family 52E--P--- GRAS family transcription factorEM----- FilaggrinEM----- Nucleotide-sensitive chloride conductance regulator (ICln)----B-- Invasion protein B familyEM----- KCNQ voltage-gated potassium channelEM----- K-Cl Co-transporter type 1 (KCC1)EM----- Macrophage scavenger receptor----B-- Conjugal transfer proteinE-F---- Meiotic recombination protein rec114----B-- Colicin E1 (microcin) immunity protein----B-- RHS proteinEM----- RabaptinEM----- Otx1 transcription factorEM----- Calcium-activated SK potassium channelEMFP--- Structure-specific recognition protein (SSRP1)

OMS28 porinEM----- SPO11 homologueEM----- Paxillin family----BA- TM1410 hypothetical-related protein----B-- Salmonella virulence plasmid 28.1kDa A protein------V Spumavirus aspartic protease (A9)EMF---- Transcription initiation factor TFIID 23-30kDa subunitEMF---- Tuberin----B-- Yersinia/Haemophilus virulence surface antigen----B-- Gram-negative bacterial tonB protein----B-- Yersinia virulence determinant (YopE)EM----- Treacher Collins syndrome protein TreacleEMFPBA- Membrane transport protein----BA- Outer membrane lipoprotein carrier protein LolA----BA- Transcriptional regulator PadR-like family

Sheet1

E--PB-- Cellulose synthase------V UL73 viral envelope glycoprotein EMF---- Domain of unknown function (DUF298)

NDP-hexose 2,3-dehydrataseEMF-B-- Allantoicase repeat----B-- MltA specific insert domain------V Bunyavirus glycoprotein G2

Protein of unknown function (DUF1759)Peptidase family A21

EM----- Sulfotransferase familyEMF---- Peptidase family C50EMFP--- Peptidase family M49EM--BA- Peptidase family S41----B-- outer membrane porin, OprD familyEM--B-- Peptidase family S51----B-- Peptidase family S58 EM--B-- Peptidase family C69------V Small hydrophobic protein------V Herpesvirus UL14-like protein------V Herpesvirus UL33-like proteinE-F---- Secretory lipase ------V Herpesvirus ICP4-like protein N-terminal region------V Herpesvirus ICP4-like protein C-terminal region------V Herpesvirus UL36 tegument proteinEMF--A- EMG1/NEP1 methyltransferase----B-- Leucyl/phenylalanyl-tRNA protein transferase----B-V Antitermination protein----B-V Terminase small subunit ----B-- Benzoate membrane transport proteinE-F-BA- C4-dicarboxylate transporter/malic acid transport protein

Cadmium resistance transporter----B-- Cytochrome oxidase maturation protein cbb3-type----BA- CO dehydrogenase/acetyl-CoA synthase complex beta subunit----BA- CO dehydrogenase/acetyl-CoA synthase delta subunitEMFPBA- Citrate transporter----BA- Conserved hypothetical protein 698----B-- Conserved hypothetical protein 95----B-- DNA polymerase III psi subunitEMF--A- DNA directed RNA polymerase, 7 kDa subunit----B-- Anaerobic c4-dicarboxylate membrane transporter----B-- C4-dicarboxylate anaerobic carrierEM----- Doublecortin----B-- PTS system enzyme II sorbitol-specific factor----B-- PTS system sorbose-specific iic component----B-- PTS system sugar-specific permease component----B-- Sorbitol phosphotransferase enzyme II N-terminus----B-- PTS system mannose/fructose/sorbose family IID component----B-- Repressor of phase-1 flagellinEM----- GCM motif protein----B-- Sodium/glutamate symporter------V IBV 3A protein E--PB-- Domain of unknown function (DUF299) EMF---- Domain of unknown function ----B-- MbtH-like proteinEM----- Focal adhesion targeting region----B-- Prokaryotic Cytochrome C oxidase subunit IV EM-PB-- Domain of unknown function (DUF303)

Sheet1

EMFPB-- Fumble ----B-- Ribonuclease BN-like familyEMF-B-- Glycosyl hydrolase family 65 central catalytic domainE-F-B-- Glycosyl hydrolase family 65, C-terminal domain E--P--- TCP family transcription factorEMF---- Vacuolar protein sorting-associated protein 35 EMFP--- Mob1/phocein familyEM----- Tesmin/TSO1-like CXC domain

Secreted repeat of unknown functionEMFP--- Vacuolar protein sorting-associated protein 26 EM----- Glycosyl hydrolase family 85 EMF---- Tctex-1 family----B-- FlaG proteinEMFP--- Transmembrane proteins 14CE-F-B-- Glycosyl hydrolase family 67 N-terminusE--PBA- Uncharacterised protein family (UPF0014)EMF---- Uncharacterised protein family (UPF0041)----B-- Uncharacterised protein family (UPF0081)----B-- Uncharacterised protein family (UPF0093)EMF---- Pam16EMF--A- Uncharacterised protein family (UPF0113)E-F---- Glycosyl hydrolase family 71 EMFP--- PHF5-like proteinEMF---- Uncharacterised protein family (UPF0121)EM-P--- Glycosyl hydrolase family 79, N-terminal domain E-F-B-- Glycosyl hydrolase family 76 EM-P--- Uncharacterised protein family (UPF0172)EMF---- Nitrogen Permease regulator of amino acid transport activity 3----B-- P-loop ATPase protein familyEMFP--- Uncharacterised protein family (UPF0139)EM----- Uncharacterised protein family (UPF0184)EM-P--- Ubiquitin fold modifier 1 protein----B-- Uncharacterised protein family (UPF0154)----BA- Uncharacterised protein family (UPF0128)EM-P--- Uncharacterised protein family (UPF0183)----B-- Uncharacterised protein family (UPF0137)------V Hexon, adenovirus major coat protein, C-terminal domain----BAV Uncharacterised protein family (UPF0150)----B-- Uncharacterised protein family (UPF0158)-----A- Uncharacterised protein family (UPF0147)-----A- Uncharacterised protein family (UPF0146)------V Nepovirus coat protein, N-terminal domainEMF-B-- Uncharacterised protein family (UPF0160)----B-- Uncharacterised protein family (UPF0167)----BA- Uncharacterised protein family (UPF0153)EMFP--- Erg28 like protein----B-- Uncharacterised protein family (UPF0149)----B-- Uncharacterised protein family (UPF0180)----BA- Uncharacterised protein family (UPF0182)EM----- Sorting nexin, N-terminal domain ----B-- Uncharacterised protein family (UPF0075)----B-- Bacterial membrane flanked domainEM--B-- Bacterial transcriptional activator domain----B-- CheR methyltransferase, all-alpha domain----BA- Uncharacterised protein family (UPF0104)----B-- Bacterial signalling protein N terminal repeat------V Avian retrovirus envelope protein, gp85

Sheet1

----B-- Orn/Lys/Arg decarboxylase, N-terminal domain----B-- Glutamate-ammonia ligase adenylyltransferase----B-- Orn/Lys/Arg decarboxylase, C-terminal domainEM----- Copper type II ascorbate-dependent monooxygenase, C-terminal domain------V Domain of unknown function (DUF305)EMFP--- Noc2p family------V WCCH motif E--PB-- Penicillin-binding Protein dimerisation domainEMFPBA- Ribosomal protein S5, C-terminal domainEM-PBA- UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domainEM-PBA- UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domainEM----- Hemocyanin, all-alpha domainEM----- Hemocyanin, ig-like domain----B-- META domainEMF-BA- 3' exoribonuclease family, domain 2EM--B-- Polyribonucleotide nucleotidyltransferase, RNA binding domainEMFP--- Hexokinase------V Viral DNA-binding protein, zinc binding domainEMF---- Ku70/Ku80 C-terminal armEMF---- Ku70/Ku80 N-terminal alpha/beta domainEMF---- Retrotransposon gag protein EM----- ENT domainEM----- EPTP domainE-FPBA- Demethylmenaquinone methyltransferaseE---B-- Glutathionylspermidine synthase----B-- Predicted permease YjgP/YjgQ family----B-- Pyridoxal phosphate biosynthesis protein PdxJ----B-- Integral membrane protein TerC family----BA- 6-carboxyhexanoate--CoA ligase----B-- Domain of unknown function (DUF309)E-F-BA- LamB/YcsF familyEM--BAV ADP-ribosylglycohydrolase----B-- Flagellar basal body-associated protein FliL----BA- Sugar fermentation stimulation protein-----A- Protein of unknown function (DUF310)------V Human herpesvirus 6 immediate early protein ----B-- YicC-like family, N-terminal region ----B-- A-factor biosynthesis repeatE--P--- PRONE (Plant-specific Rop nucleotide exchanger)E--P--- Late embryogenesis abundant (LEA) group 1

Domain of unknown function (DUF316) EM----- Vitelline membrane outer layer protein I (VOMI) E--P--- Remorin, C-terminal region EMFPBA- Elongation factor G, domain IVEMFP--- CRAL/TRIO, N-terminusE--PB-- HAD superfamily, subfamily IIIB (Acid phosphatase)EM----- Attacin, N-terminal regionEM----- Attacin, C-terminal regionEMFP--- Inositol polyphosphate kinase

Domain of unknown function (DUF317)----B-- Competence protein----BA- Predicted permeaseE---B-- Septum formation topological specificity factor MinE

Small secreted domain (DUF320) Protein of unknown function (DUF321) SPW repeat

----B-- Protein of unknown function (DUF322)

Sheet1

EMF-B-- Formylglycine-generating sulfatase enzymeEM----- AMOP domain----B-- Peptidase family C25, C terminal ig-like domain----B-- D-mannonate dehydratase (UxuA)-----A- RAMP superfamily----B-- LrgA familyE--P--- ELK domain E--P--- KNOX1 domain E--P--- KNOX2 domain EM----- PBC domain----B-- PASTA domain----B-- YCII-related domainE---B-V DnaB-like helicase C terminal domainEMFP--V TLC domain----B-- Cell division protein FtsQEMF---- Nuf2 familyEMF---- HEC/Ndc80p family----B-- Apo-citrate lyase phosphoribosyl-dephospho-CoA transferaseEMF---- Scramblase ------V Viral domain of unknown function----B-- AbgT putative transporter familyEMFPBA- NADP oxidoreductase coenzyme F420-dependent----B-- Glycosyl transferase WecB/TagA/CpsF familyEMFP--- Importin-beta N-terminal domain----BA- Insertion element proteinEMF---- Nrap proteinEMF---- LCCL domain

Malonate/sodium symporter MadM subunitEM--BAV MazG nucleotide pyrophosphohydrolase domainEMF---- Tricarboxylate carrierEM----- Golgi 4-transmembrane spanning transporterE--P--- NAF domainE-F-BA- High-affinity nickel-transport protein----B-- Nucleoside H+ symporterEM----- OAR domainEM----- Orexin receptor type 2EMF---- Poly(A) polymerase----B-- PTS system glucitol/sorbitol-specific IIA component----B-- PTS system sorbose subfamily IIB component----B-- PhnA proteinEM----- WSK motif-----A- DNA polymerase II large subunit DP2EMFP--- Binding domain of DNA repair protein Ercc1 (rad10/Swi10)EMFP--- Rad4 transglutaminase-like domainEMF---- RasGAP C-terminusEMF---- Translocation protein Sec62E---B-- Preprotein translocase SecG subunit----BA- L-seryl-tRNA selenium transferase

Silicon transporter----B-- Outer membrane lipoprotein Slp family----B-- Spore germination proteinEMF---- Transcription initiation factor TFIID subunit A----B-- Tellurite resistance protein TehBEMF---- Transcription factor Tfb2EMF---- Transcription factor Tfb4E-F-B-V UV-endonuclease UvdE----B-- DNA mismatch endonuclease Vsr

Sheet1

EMF-BA- YjeF-related protein N-terminus------V P-11 zinc fingerE-F---- M-factorEM--B-- Colicin immunity proteinEM-P--- CG-1 domain

Domain of Unknown Function (DUF326) ----B-- ANTAR domain------V Phage maturation protein----B-V Phage major capsid protein E----B-- Haemolysin secretion/activation protein ShlB/FhaC/HecBE------ Hydrophobic abundant protein (HAP) EM----- Fushi tarazu (FTZ), N-terminal regionEM-P--- Ribosomal protein L6, N-terminal domain----B-V Arc-like DNA binding domainEMF---- RNA polymerase Rpb8EMF---- RNA polymerase Rpb5, N-terminal domain----B-- Anti sigma-E protein RseA, C-terminal domainEMF--A- RNA polymerase Rpb4EM----- StatherinEMFP-AV RNA polymerase Rpb7-like, N-terminal domainEMF---- YIF1E-F---- Cgr1 family----B-- DbpA RNA binding domain EM-PB-- Fructosamine kinase----B-- Protein of unknown function (DUF328)----B-- Domain of unknown function (DUF329)----B-- Protein of unknown function (DUF327)----BA- YfbU domain----B-- MucB/RseB family----B-- Domain of unknown function----BA- Domain of unknown function (DUF333)----B-- Nitrate reductase cytochrome c-type subunit (NapB)E-F-B-- D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase----B-- YadA-like C-terminal regionEM-P--- Translocon-associated protein (TRAP), alpha subunit----B-- ATP synthase I chainEMFPBA- Porphobilinogen deaminase, C-terminal domainEMF-B-- Alg9-like mannosyltransferase familyE-F---- Gal4-like dimerisation domain----B-- Domain of unknown function (DUF334)------V Phage T7 tail fibre proteinE-F---- Spo7-like proteinEMF---- Sec20EMF---- BSD domain ------V Adenovirus minor core protein PVEMFP-A- Sec61beta familyE--PB-- Psb28 proteinEMF---- CBF/Mak21 familyEMF---- Actin interacting protein 3----BA- Polysulphide reductase, NrfDEMFP--- Eukaryotic glutathione synthase, ATP binding domain----B-- Cytochrome C biogenesis proteinEMF---V mRNA capping enzyme, C-terminal domainEM----- Groucho/TLE N-terminal Q-rich domainEM----- Intercellular adhesion molecule (ICAM), N-terminal domainE------ CHASE domain----B-- SeqA protein

Sheet1

----B-- NapD proteinE-F-B-- Domain of unknown function (DUF336)

PepSY-associated TM helixE-F---- Recombinase Flp protein N-terminusEMFP--- Skp1 family, tetramerisation domainEM--B-- CutC familyEM--B-- General secretion pathway protein KE-F---- Beta-glucan synthesis-associated protein (SKN1)E-FPB-- Terpene synthase family, metal binding domainEMF-B-- Protein of unknown function (DUF339)----B-- Outer membrane protein (OmpH-like)EMFP--- Ribosomal protein L23, N-terminal domainEM----- Male specific sperm proteinEMF---- Inner centromere protein, ARK binding regionEM--B-- DTW domainEMF---- TAP C-terminal domain----B-- delta endotoxinE---B-- delta endotoxin, N-terminal domainEMFPBA- Ribosomal protein L11, N-terminal domainEMFPBA- Ribosomal Proteins L2, C-terminal domainE--PB-- Ribosomal protein L9, C-terminal domainEMFPB-- Malic enzyme, NAD binding domainEMFPBA- tRNA synthetases class I (E and Q), anti-codon binding domainEMFPBAV Glutamine synthetase, beta-Grasp domainEMFPBA- Enolase, N-terminal domainEMFP--- Tubulin C-terminal domainEM----- Hepatic lectin, N-terminal domain------V Adenovirus hexon-associated protein (IX)EM----V Jun-like transcription factor----B-V Bacterial type II/III secretion system short domainEMF---- Serine hydrolase (FSH1)----B-- ArsC family

Protein of unknown function (DUF342)EMFP--- Mnd1 familyEM----- Chorion family 2----B-- Penicillinase repressorEMFPB-- Trm112p-like protein----B-- Photosynthetic reaction centre, H-chain N-terminal region----B-- OstA-like proteinEMF-B-- AFG1-like ATPaseEMF-B-- MmgE/PrpD familyEM----- TriabinE---B-- Ecotin----B-- Polyphosphate kinase 2 (PPK2)

Borrelia burgdorferi REV protein----B-- Sigma-70 factor, region 1.1EMF---- Nnf1 EMF-B-- Ubiquinol-cytochrome C chaperone EMFP--- Diacylglycerol acyltransferase

Repeat of unknown function (DUF346) EMF---- Paf1 EMFP--- Autophagocytosis associated protein (Atg3), N-terminal domain EMFP--- Autophagocytosis associated protein, active-site domain

Repeat of Unknown Function (DUF347) E--PB-- DNA gyrase C-terminal domain, beta-propellerE-F-B-- Domain of unknown function (DUF348)

Domain of Unknown Function (DUF349)

Sheet1

----B-- Domain of Unknown Function (DUF350) ------V Hemagglutinin esteraseEMFP--- VPS28 proteinEMFP--- Utp11 proteinEMF---- Microtubule associated protein (MAP65/ASE1 family)EMF---- Sas10/Utp3/C1D familyE-F---- Transcription factor Vhr1----BA- Protein of unknown function (DUF2466)EMF---- Dip2/Utp12 FamilyEMF---- Leo1-like proteinEMF---- Hus1-like proteinEMF---- Mpp10 protein-----A- Protein of unknown function (DUF354)-----A- Protein of unknown function (DUF356)-----A- Protein of unknown function (DUF357)----BA- LemA familyE--PB-- PspA/IM30 family----BA- Protein of unknown function (DUF358)----BA- SpoVT / AbrB like domain

Domain of unknown function (DUF368)-----A- Protein of unknown function (DUF359)----B-- Membrane protein of unknown function----B-- Staphylocoagulase repeat----BA- FeoA domain----B-- PspC domain----B-- Domain of unknown function (DUF370)----BA- SpoVG-----A- Domain of unknown function (DUF371)----B-- Domain of unknown function (DUF374)----BA- 2-phosphosulpholactate phosphataseEMFPB-- D-arabinono-1,4-lactone oxidase EMF---- Las1-like EMF--A- RNAse P Rpr2/Rpp21/SNM1 subunit domainEMF--A- Domain of unknown function (DUF367)-----A- Domain of unknown function (DUF372)EMF---- Domain of unknown function (DUF382) ----BA- Domain related to MnhB subunit of Na+/H+ antiporter

Domain of unknown function (DUF377)EMFP-A- DNA polymerase alpha/epsilon subunit BE--P--- Plant invertase/pectin methylesterase inhibitorEMF---- Arp2/3 complex, 34 kD subunit p34-ArcEMF---- PSPEMFP--- Sec8 exocyst complex component specific domainEMF---- Anaphase promoting complex subunit 8 / Cdc23 EMF---- Up-frameshift suppressor 2 EMF---- Transport protein particle (TRAPP) component----B-- TolB amino-terminal domainEMFP--- Coatomer WD associated region EMF---- CCR4-Not complex component, Not1EMFPBA- Radical SAM superfamilyEMFP--- Ssl1-likeEMF---- Replication factor-A protein 1, N-terminal domainE-FP--- RNA recognition motif 2----BA- Putative Fe-S clusterEMF---- ORMDL family EMF---- ARP2/3 complex ARPC3 (21 kDa) subunitEMF---- Domain of unknown function (DUF383)

Sheet1

EMF---- Domain of unknown function (DUF384)EMF-B-- Not1 N-terminal domain, CCR4-Not complex component EMFP-A- Possible metal-binding domain in RNase L inhibitor, RLI-----A- Cysteine-rich small domainEMF-B-- Leucine carboxyl methyltransferaseEMF-B-- YbaK / prolyl-tRNA synthetases associated domain----B-- Bacterial OB fold (BOF) protein----B-- DsrH like proteinEMF---- Cell differentiation family, Rcd1-like ----B-- Putative transcriptional regulators (Ypuh-like)EMF---- Per1-like EMF---- DNA polymerase delta, subunit 4 E-F---- Fungal specific transcription factor domain EMFP--- ab-hydrolase associated lipase regionEMFP--- Origin recognition complex subunit 2 ----B-- rod shape-determining protein MreCEMF---- Signal recognition particle, alpha subunit, N-terminal-----A- Domain of unknown function (DUF389) EMF---- Peroxin 13, N-terminal regionEM----- BRICHOS domainE-F---- RNA polymerase I specific initiation factorEMFP--- Exocyst complex subunit Sec15-like E------ SRS domain----B-- rod shape-determining protein MreD

Protein of unknown function (DUF390)EMF-BA- Nicotinate phosphoribosyltransferase (NAPRTase) familyEMF---- Nucleoporin autopeptidaseEMFP--- Nup93/Nic96EMF---- Rad52/22 family double-strand break repair proteinEMF---- Sybindin-like family EMF---- Vps53-like, N-terminal EMFPBA- Glycosyltransferase family 28 C-terminal domain----B-- SlyXEM----- CD20-like familyEMFP-A- Eukaryotic and archaeal DNA primase, large subunitEMFP--- Autophagy protein Apg5 E--PBA- Glutamate-cysteine ligase family 2(GCS2)E-F---- Autophagy protein Apg17 EMF---- Autophagy protein Apg9 EMFP--- Ubiquitin-like autophagy protein Apg12 EMFP--- Autophagy protein Apg6EMF---- Mak10 subunit, NatC N(alpha)-terminal acetyltransferaseEMF---- Gpi16 subunit, GPI transamidase componentEMF---- Gaa1-like, GPI transamidase component E-F-B-- Ureidoglycolate hydrolase EMFPB-- Fatty acid hydroxylase superfamilyEMFP--- Mpv17 / PMP22 family EMF---- Dopey, N-terminalE-F---- Heat shock protein 9/12E-F---- Low affinity iron permease EMF---- Nuclear pore protein 84 / 107 ----BA- Putative cell wall binding repeat 2-----A- Domain of unknown function (DUF373)EMF---- Dor1-like family EMF-BA- DNA / pantothenate metabolism flavoproteinEMF---- Vps52 / Sac2 family EMFP--- Spc97 / Spc98 family

Sheet1

----B-- Putative N-acetylmannosamine-6-phosphate epimeraseEMFP--- Vacuolar protein sorting 55 E--PB-- Protein of unknown function, DUF393EMFP-A- Nucleolar RNA-binding protein, Nop10p familyEMF---- Sec34-like family EMFP--- Endoplasmic Reticulum Oxidoreductin 1 (ERO1)----B-V GtrA-like proteinEMF---- Rad9EMFPB-- Isoprenylcysteine carboxyl methyltransferase (ICMT) family EMF---- Nucleotide-sugar transporter----B-- YeeE/YedE family (DUF395)EM-P--- SCAMP familyEMFP--- Ctr copper transporter familyEMFP--- YT521-B-like familyEMF---- Nop14-like family EMF---- Transmembrane adaptor Erv26

Domain of unknown function (DUF397)----BA- Bacterial pre-peptidase C-terminal domainEMFP--- Mre11 DNA-binding presumed domain EMF---- NOT2 / NOT3 / NOT5 family

Ground-like domain----B-- IncA proteinEMFP--- EAP30/Vps36 familyEMF---- Sof1-like domain ------V NB glycoproteinEMF---- Arv1-like family ------V Gyrovirus capsid protein (VP1)E-F---- Tht1-like nuclear fusion protein

Protein of unknown function, DUF400Protein of unknown function (DUF401)

----BA- Protein of unknown function (DUF402)----B-- Bacterial domain of unknown function (DUF403)----B-- Domain of unknown function (DUF404)----B-- Uncharacterized lipoprotein NlpE involved in copper resistance----B-- LrgB-like family ----B-- Domain of unknown function (DUF407)----B-- Protein of unknown function (DUF406) EMF---- TIP41-like family EMFP--- TAP42-like familyEMF---- Got1/Sft2-like family E-F---- Initiator tRNA phosphoribosyl transferase EMF---- Low temperature viability protein EMF-B-- Rtr1/RPAP2 familyEMF---- B-block binding subunit of TFIIIC----B-- IucA / IucC familyEM----- ST7 protein----B-- FxsA cytoplasmic membrane protein

Protein of unknown function, DUF399EMF---- Mannosyltransferase (PIG-V))EMF---- Gcd10p familyEMF---- Protein of unknown function (DUF410) EMF---- Utp21 specific WD40 associated putative domain EMFPBA- PQ loop repeat EMF---- Programmed cell death protein 2, C-terminal putative domain

Putative gypsy type transposon----B-- Putative sugar-binding domain

Lipoprotein associated domain

Sheet1

EM----- Tumour protein D52 family----B-- Sortase family----B-- FMN-binding domain-----A- Tetrahydromethanopterin S-methyltransferase, subunit E -----A- Tetrahydromethanopterin S-methyltransferase, subunit D -----A- Tetrahydromethanopterin S-methyltransferase, subunit A EMFPBA- homogentisate 1,2-dioxygenase-----A- Tetrahydromethanopterin S-methyltransferase, subunit G EMF---- MIT (microtubule interacting and transport) domain

Htaa----B-- Protein involved in formate dehydrogenase formation----B-- Protein of unknown function, DUF412EM----- CENP-B N-terminal DNA-binding domain----B-- Protein of unknown function, DUF----B-- Protein of unknown function, DUF414----B-- RelB antitoxin----B-- Protein of unknown function, DUF----B-- Citrate lyase, alpha subunit (CitF)----B-- Protein of unknown function, DUF417----B-- Opacity-associated protein A LysM-like domain----B-- Transglycosylase associated proteinE-F-B-- Indigoidine synthase A like protein----B-- Putative neutral zinc metallopeptidaseE-F-B-V Polysaccharide pyruvyl transferase----B-- Endonuclease I----B-- Stage V sporulation protein S (SpoVS)----BAV Phage Mu protein F like protein----B-- Copper resistance protein CopC----B-- Protein of unknown function (DUF418)

Tc5 transposase C-terminal domain----B-- Protein of unknown function (DUF419)----B-- Protein of unknown function (DUF420)----B-- Protein of unknown function (DUF421)

Protein of unknown function (DUF422)EMF-B-- Protein of unknown function (DUF423)------V Protein of unknown function (DUF424)------V Deoxyribodipyrimidine photo-lyase-related protein----B-- Positive regulator of sigma(E), RseC/MucC

Protein of unknown function (DUF429)EMFP--- Transferrin receptor-like dimerisation domain

Protein of unknown function (DUF432)----BA- Protein of unknown function (DUF433)-----A- Protein of unknown function (DUF434)----B-- Exodeoxyribonuclease V, gamma subunit EMF---- Signal peptide peptidase----B-- Protein of unknown function (DUF436) ----B-- Dyp-type peroxidase family ----B-- Glutamate-cysteine ligase EMF-B-- Thiamin pyrophosphokinase, catalytic domain----B-- YceI-like domainEMF-B-- Thiamin pyrophosphokinase, vitamin B1 binding domainEM--B-V ASCH domain----B-- Sarcosine oxidase, delta subunit family ----B-- Sarcosine oxidase, gamma subunit family ----B-- Protein of unknown function, DUF440EM----- PhospholambanEM----- Phosphomevalonate kinase

Sheet1

Protein of unknown function (DUF443) ----B-- Oxaloacetate decarboxylase, gamma chain ----B-- Intracellular septation protein A EMF-B-- Tim44-like domainEMF---- Mitochondrial import receptor subunit Tom22

Family of unknown function (DUF438)-----A- Chemotaxis signal transduction system protein F from archaea----B-- Protein of unknown function (DUF441)----BA- Protein of unknown function (DUF444)----B-- Protein of unknown function (DUF445)----B-- Domain of unknown function, DUF446----B-- MukE-like family-----A- Protein of unknown function (DUF447)----B-- Tripartite ATP-independent periplasmic transporters, DctQ component----B-- D-galactarate dehydratase / Altronate hydrolase, C terminus----B-- Protein of unknown function (DUF448)----B-- Putative helix-turn-helix protein, YlxM / p13 like

Putative neutral zinc metallopeptidaseE-F-B-- Putative FMN-binding domainEM----- F-box associated region----B-- Protein of unknown function (DUF452)----B-- Protein of unknown function (DUF454)----BA- Predicted membrane-bound metal-dependent hydrolase (DUF457)----B-- Protein of unknown function (DUF458) ----B-- Glycerol-3-phosphate responsive antiterminator----B-- MukB N-terminal

Protein of unknown function (DUF459)Protein of unknown function (DUF460)

----BA- Type I restriction enzyme R protein N terminus (HSDR_N)----B-- Protein of unknown function (DUF461)----B-- Protein of unknown function, DUF462----B-- Anti-sigma-28 factor, FlgM----B-- NifZ domainEM-PB-V RmlD substrate binding domain-----A- Protein of unknown function (DUF473)E-F-BA- BFD-like [2Fe-2S] binding domainEM--B-- Protein of unknown function (DUF465)EM--B-- Divergent AAA domain----B-- Protein of unknown function (DUF466)----B-- VacJ like lipoprotein----B-- VirB8 protein----B-- Protein of unknown function, DUF479----B-- Protein of unknown function, DUF480----B-- Protein of unknown function, DUF481

Protein of unknown function, DUF482----B-- Protein of unknown function, DUF484----B-- Protein of unknown function, DUF485

Protein of unknown function, DUF486----B-- Protein of unknown function, DUF488----B-- Chemotaxis phosphatase, CheZ----B-- LppC putative lipoprotein----B-- Periplasmic glucan biosynthesis protein, MdoG

Pilus assembly protein, PilO----B-- Pilus assembly protein, PilP----B-- Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ----B-- SmpA / OmlA family----B-- Protein of unknown function (DUF489)

Sheet1

----B-- DsrC like protein----B-- Protein of unknown function (DUF493)EM----- Serglycin ----B-- Protein of unknown function (DUF494)----B-- Protein of unknown function (DUF496)----B-- DNA polymerase III chi subunit, HolC

Protein of unknown function (DUF497)EMF---- Family of unknown function (DUF500)


EM----- Domain of unknown function (DUF508) E--PB-- Porphyromonas-type peptidyl-arginine deiminase

Protein of unknown function (DUF511)----B-- HemXEMFPB-- Arginine-tRNA-protein transferase, N terminusEMFPB-- Arginine-tRNA-protein transferase, C terminusEM-PB-- Protein of unknown function (DUF525)----B-- Protein of unknown function (DUF526)EM----- SAB domainE-F---V KilA-N domain----B-- Protein of unknown function (DUF528)

Domain of unknown function, DUF529----B-- Stringent starvation protein BEMFP--- Protein tyrosine phosphatase-like protein, PTPLAEMF---- Hamartin proteinEMFPB-- Peptidase family M28----B-- Rare lipoprotein B family----B-- Protein of unknown function (DUF533)E------ Poxvirus B22R protein----B-- LytTr DNA-binding domainE--P--- Protein of unknown function, DUF538----B-- Glutaredoxin 2, C terminal domain----B-- Protein of unknown function (DUF540)EM--B-- Protein of unknown function (DUF541)------V ERF superfamily----B-- Domain of Unknown function (DUF542) EMFP-A- Type IIB DNA topoisomeraseEMFPB-V Helicase associated domain (HA2)-----A- Protein of unknown function (DUF530)EMFP-A- Gar1/Naf1 RNA binding region

Protein of unknown function (DUF524)-----A- Protein of unknown function (DUF521)----B-- 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)-----A- Protein of unknown function (DUF515)

Protein of unknown function (DUF501)EMF---- Domain of unknown function (DUF543)EMFP--- 4F5 protein familyEMF---- CHD5-like proteinEMF---- Mss4 protein----BA- Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-termEMFP-A- Rad50 zinc hook motifEMF---- Protein of unknown function (DUF544) E-F---- Bul1 N terminusE-F---- Bul1 C terminusEMFP-A- Brix domainE-F---- Choline kinase N terminusEM--B-- Protein of unknown function (DUF498/DUF598)

Sheet1

E--P--- Pectate lyase, N terminus----BA- Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminusEMFP--- SWIRM domainEM-PBA- SWIM zinc finger

Domain of unknown function (DUF545) EMF---- RINT-1 / TIP-1 familyEMFP--- HIT zinc finger----B-- Streptomycin adenylyltransferaseEM----- Dysbindin (Dystrobrevin binding protein 1)------V Poxvirus early transcription factor (VETF), large subunit EMF-B-- Cytochrome c oxidase assembly protein CtaG/Cox11----B-- Protein of unknown function (DUF548)EMF---V tRNAHis guanylyltransferase------V Protein of unknown function (DUF551)

Plant Basic Secretory Protein ----B-- RNA methyltransferase----B-- Encapsulating protein for peroxidase----B-- Protein of unknown function (DUF503)-----A- Protein of unknown function (DUF505)----B-- Protein of unknown function (DUF520)----B-- CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase ----B-V Phage terminase large subunitE-F-B-- PSP1 C-terminal conserved regionE---BA- Protein of unknown function (DUF552)-----A- Protein of unknown function (DUF555)E-F---- Mid2 like cell wall stress sensor----B-- Protein of unknown function (DUF559)E------ Protein of unknown function (DUF561)

Family of unknown function (DUF566) E---B-- Phycobilisome degradation protein nblA ----B-- SchA/CurD like domainEM----- CITEDEMFPB-V Glycosyltransferase sugar-binding region containing DXD motif ------V Protein of unknown function (DUF570) ------V Poxvirus T4 protein, C terminus------V Bacteriophage replication protein O EMF---- WD40 associated region in TFIID subunitEMF---- GRASP55/65 family ------V Herpesvirus UL35 family EMF---- SIT4 phosphatase-associated proteinEM----- FLYWCH zinc finger domain------V Baculovirus major capsid protein VP39EMF---- Family of unknown function (DUF572) EMF---- Single-stranded DNA binding protein, SSDP

Protein of unknown function, DUF573EM----- Interferon-induced transmembrane proteinEMF---- Rft protein------V Viral A-type inclusion protein repeat

Family of unknown function (DUF577)EMFP--- Der1-like family------V Baculovirus polyhedron envelope protein, PEP, N terminus------V Baculovirus polyhedron envelope protein, PEP, C terminus ------V Bluetongue virus non-structural protein NS2EMF---- Plasma-membrane choline transporterEM----- CP2 transcription factor------V Microvirus lysis protein (E), C terminus

Protein of unknown function, DUF582

Sheet1

----B-- Protein of unknown function, DUF583Protein of unknown function, DUF584

------V ssRNA positive strand viral 18kD cysteine rich protein------V Protein of unknown function (DUF585)------V Herpes virus tegument protein U30E--PB-- Protein of unknown function (DUF567)

Drosophila Retinin like protein------V Adenovirus early E4 34 kDa protein conserved region------V Herpesvirus U59 protein ------V Viral Beta C/D like family

Bacteriophage holin------V Protein of unknown function (DUF587)------V Herpes virus U44 protein------V Herpesvirus UL56 protein------V Herpesvirus UL55 proteinEM----- Brain expressed X-linked like family ----B-- Sigma-70 region 3----B-- Sigma-70 region 2 ----BA- Sigma-70, region 4----B-- Sigma-70, non-essential regionEMF---- Calcium-activated chloride channelEM-P--- AIG1 family------V Phage holin family 2 ----B-- Sigma-54, DNA binding domainEM----- Tis11B like protein, N terminus----B-- Restriction endonuclease XhoI----BA- DpnII restriction endonucleaseEMFP--- Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 EMFP--- Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 ------V Herpesvirus UL17 proteinEMFPBAV RNA polymerase Rpb2, domain 7EMFPBAV RNA polymerase Rpb2, domain 2E------ Dictyostelium spore coat protein, N terminusEMFPBAV RNA polymerase beta subunitEMFP--V U-box domainEMFPBAV RNA polymerase Rpb2, domain 3EMFP-AV RNA polymerase Rpb2, domain 4EMFP-AV RNA polymerase Rpb2, domain 5EMF---- Mitochondrial ATPase inhibitor, IATP

Protein of unknown functionProtein of unknown function (DUF581)

EMF---- lipin, N-terminal conserved regionEM-P--- Alpha 1,4-glycosyltransferase conserved regionEMFP--- Signal peptidase subunitE-F---- Protein of unknown function (DUF592)----B-- Protein of unknown function (DUF560)

Protein of unknown function, DUF593EM----- Protein of unknown function (DUF563)EM----- Keratin, high-sulphur matrix protein------V Reovirus sigma C capsid protein------V Baculoviridae p74 conserved region------V Poxvirus A28 familyEM---A- ADP-specific Phosphofructokinase/Glucokinase conserved regionEMFP--- Hypoxia induced protein conserved region

Protein of unknown function, DUF596EM----- Selenoprotein P, N terminal region------V Poxvirus protein F15

Sheet1

EMF---- Ribophorin IEM----- Gasdermin family------V Poxvirus G5 protein


----B-- Mycobacterial cell wall arabinan synthesis protein----B-- Type-A lantibiotic----B-V Ogr/Delta-like zinc finger----B-- Region found in RelA / SpoT proteins----BA- Phosphatidylglycerophosphatase A----BA- TrbL/VirB6 plasmid conjugal transfer proteinE-F---- Mating type protein A alpha Y mating type dependent binding region ----B-- General secretion pathway, M protein----B-- UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD EMF---- Pex19 protein familyEMF---- Utp14 proteinE--P--- HD-ZIP protein N terminus----B-- Flagellar filament outer layer protein FlaaEM----- PEA3 subfamily ETS-domain transcription factor N terminal domain------V Adenovirus E1B protein N-terminusEM----- Dec-1 repeatEM----- DEC-1 protein, N-terminal regionEM----- Dec-1 protein, C terminal regionEMFP--- Mitochondrial ATP synthase epsilon chainEMF---- Sedlin, N-terminal conserved regionEM----- Islet cell autoantigen ICA69, C-terminal domain

Phage major tail protein------V Baculovirus hypothetical protein----B-- Fusaric acid resistance protein family------V Herpesvirus BMRF2 protein

Protein of unknown function, DUF600EM----- PA26 p53-induced protein (sestrin)------V Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)------V Baculoviral E56 protein, specific to ODV envelopeE--P--- PLATZ transcription factorEMF---- Replication termination factor 2

Protein of unknown function, DUF601EM----- Motilin/ghrelin-associated peptide

Protein of unknown function, DUF603Protein of unknown function, DUF604

----B-- Accessory gene regulator B----B-- YSIRK type signal peptide------V Poxvirus A12 proteinEMFP--- Vta1 like

Protein of unknown function, DUF599----B-- Aminoglycoside/hydroxyurea antibiotic resistance kinase----B-- Protein of unknown function, DUF606EMF---- TAFII55 protein conserved region-----A- Archaeal flagella protein ------V Nanovirus coat protein------V Poxvirus I3 ssDNA-binding protein------V Luteovirus P0 protein------V Poxvirus A32 proteinEM----- N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved regionEMF---- cAMP-regulated phosphoprotein/endosulfine conserved regionEM----- Twisted gastrulation (Tsg) protein conserved regionEMF---- Protein of unknown function (DUF579)

Sheet1

EMF---- Gtr1/RagA G protein conserved regionErythrocyte membrane-associated giant protein antigen 332 Protein of unknown function (DUF574)

----B-- Polyketide synthesis cyclasePhosphate-induced protein 1 conserved region

EMFPBAV DNA ligase N terminusEMFP--- Protein similar to CwfJ C-terminus 2EMFP--- Protein similar to CwfJ C-terminus 1EM----- Protein of unknown function, DUF607EMFPBAV ATP dependent DNA ligase C terminal region

Blastomyces yeast-phase-specific proteinEMF---- Proteasome complex subunit Rpn13 ubiquitin receptorE-F---- BAF1 / ABF1 chromatin reorganising factorEM----- Protein of unknown function, DUF608

Streptomyces sporulation and cell division protein, SsgA------V Microvirus H protein (pilot protein)----B-V Phage lysis protein, holinE--P--- DNA binding protein S1FAE--P--- YABBY proteinEM----- Apolipoprotein C-I (ApoC-1)EM----V Platelet-derived growth factor, N terminal region

Archaeal putative transposase ISC1217------V Coronavirus ORF3 proteinEMF---- Peroxisomal membrane anchor protein (Pex14p) conserved regionEMF---- pinin/SDK/memA/ protein conserved regionEM----- pinin/SDK conserved regionEMF---- ARP2/3 complex 16 kDa subunit (p16-Arc)------V Structural glycoprotein p40/gp41 conserved regionE--P--- Vicilin N terminal region----B-- FaeA-like protein----B-- Thiostrepton-resistance methylase, N terminusEM----- Dickkopf N-terminal cysteine-rich regionEMF---- PRELI-like familyEM----- PellinoEM----- Apolipoprotein A-II (ApoA-II)EM-P--- Radial spokehead-like protein------V Poxvirus protein I5EM----- BCL7, N-terminal conserver regionEMFP--- ETC complex I subunit conserved regionEMF---- Mitochondrial ATP synthase g subunitEMF---- hTAFII28-like protein conserved region

Protein of unknown function (DUF506) EM----- Domain of unknown function (DUF750) EMF---- Ssu72-like protein----B-- Glycine reductase complex selenoprotein AEM----- Glycosyltransferase family 17E--P--- Photosystem II 10 kDa polypeptide PsbR------V Microvirus J proteinEM----- ELMO/CED-12 family----B-- Repeated sequence found in lipoprotein LPPEMFP--- ASF1 like histone chaperoneEM----- Intermediate filament head (DNA binding) regionEMFPB-- Coatomer epsilon subunitEM-PB-- Neutral/alkaline non-lysosomal ceramidaseEM----- Eclosion hormone----B-- Lantibiotic dehydratase, C terminusEMFP--- 5'-AMP-activated protein kinase beta subunit, interation domain

Sheet1

----B-- Bacillus transposase protein----B-- InvH outer membrane lipoprotein----B-- Monooxygenase subunit B protein------V VITF-3 subunit protein

Protein of unknown function (DUF575)Protein of unknown function, DUF612

----B-- Divergent polysaccharide deacetylaseEMFP--- PLAC8 familyEMF---- FAR-17a/AIG1-like protein----B-- Protein of unknown function (DUF615)EMF-B-- ChaC-like protein----B-- Putative transposase, YhgA-likeE--P--- PAP_fibrillinEMF---- OST3 / OST6 familyEMFP--- Pex2 / Pex12 amino terminal regionEMFP-A- Ribosomal protein S30E-FPB-- Translation initiation factor IF-2, N-terminal region

Lactococcus bacteriophage putative transcription regulatorEMF---- IKI3 familyE------ Protein of unknown function (DUF613)------V Nucleopolyhedrovirus p26 protein------V DNA-binding 11 kDa phosphoproteinEMF-B-- Protein of unknown function (DUF619)E-F---- Mating-type protein MAT alpha 1------V Chicken anaemia virus VP-3 protein------V Influenza B matrix protein 2 (BM2)EMF---- Hyaluronan / mRNA binding familyE--P--- Protein of unknown function (DUF626)EMF---V Erv1 / Alr family

LMP repeated regionProtein of unknown function (DUF629)Protein of unknown function (DUF627)Protein of unknown function (DUF632)Protein of unknown function (DUF630)Protein of unknown function, DUF547

------V Rhabdovirus matrix protein M2------V ssDNA binding protein ------V Late protein H7


EM----- Sarcoglycan complex subunit proteinEMFP--- LMBR1-like membrane protein------V BRRF1-like proteinEMF---- PAPA-1-like conserved region

Plasmid encoded RepA protein------V Herpesvirus dUTPase protein------V Baculovirus 19 kDa protein conserved regionEM----- fzo-like conserved regionEMF---- ETC complex I subunit conserved regionEMF---- Sin-like protein conserved regionEMF---- Component of IIS longevity pathway SMK-1EM----- Cor1/Xlr/Xmr conserved region------V E10-like protein conserved region

EspF protein repeatCitrus tristeza virus (CTV) P23 protein

----B-- HupH hydrogenase expression protein, C-terminal conserved regionEMFP--- Sec23/Sec24 zinc finger

Sheet1

EMFP--- Sec23/Sec24 trunk domainEM----- Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminusEMFP--- Sec23/Sec24 helical domain----B-- Family of unknown function (DUF633)

Umbravirus long distance movement (LDM) family EMF---- Protein of unknown function, DUF618EM----- Family of unknown function (DUF716) ----BA- Tryptophan halogenaseEMF---- Timeless proteinEM----- Protein of unknown function, DUF622------V Herpesvirus UL49 tegument proteinEMFP--- Conserved region of Rad21 / Rec8 like proteinEMFP--- N terminus of Rad21 / Rec8 like proteinEM----- Protein of unknown function (DUF634)EM----- Plant transposon proteinEMF-B-- Glutathione-dependent formaldehyde-activating enzyme

Possible hemagglutinin (DUF638)Possible hemagglutinin (DUF637)

EM----- Popeye protein conserved regionEM-P--- SOUL heme-binding protein------V Early E3 14.5 kDa protein------V A9 protein conserved regionEM----- Interferon-related protein conserved region----B-- MbeB-like, N-term conserved region------V Baculoviridae late expression factor 5 E--PB-- Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65)EMF---- Vps16, C-terminal regionEMF---- Vps16, N-terminal region

Plant protein of unknown function (DUF639)------V Herpesvirus tegument protein, N-terminal conserved region

Protein of unknown function, DUF623EM-P--- PurA ssDNA and RNA-binding protein------V Herpesvirus pp38 phosphoproteinEMF---- Calcipressin------V Poxvirus A22 proteinEM----- HAP1 N-terminal conserved regionEMFPBAV Type III restriction enzyme, res subunit----B-- Protein of unknown function, DUF624EMFP--- SNF5 / SMARCB1 / INI1EMF---- Securin sister-chromatid separation inhibitorEMFP--- CAF1 family ribonucleaseEM----- TH1 protein

Plant protein of unknown function (DUF641)----B-V Phage portal proteinE--P--- Alliinase EGF-like domainE--P--- Allinase------V Rotavirus non-structural protein 6

Protein of unknown function (DUF643)EMFP--- Uso1 / p115 like vesicle tethering protein, head region

Protein of unknown function (DUF644)EMFP--- Uso1 / p115 like vesicle tethering protein, C terminal regionEMF---- Mak16 protein C-terminal region------V Tenuivirus major non-capsid protein------V Baculovirus P48 protein----BA- Molybdopterin oxidoreductase Fe4S4 domainEMF---- NUDE protein, C-terminal conserved region------V Adenovirus GP19K

Sheet1

EMF---- Peroxin-3EM----- Protein of unknown function, DUF647

Stigma-specific protein, Stig1EM--B-- PT repeat------V Poxvirus M2 protein----B-- Secretion system effector C (SseC) like family EMF---- Cwf15/Cwc15 cell cycle control protein

Family of unknown function (DUF648) EMF-BA- Yip1 domain

Archaeal protein of unknown function (DUF651)E-FPB-- Glutamate synthase central domain----B-- MbeD/MobD like EMF---- Fcf1EM----- Receptor activity modifying family EM----- NAB conserved region 1 (NCD1)EM----- NAB conserved region 2 (NCD2)EM----- TweetyEM----- SH3-binding, glutamic acid-rich proteinEMF-B-- AmidohydrolaseEMF---- Protein of unknown function, DUF654E-F---- ATP synthase j chainEMF---- Dynamitin ------V Baculovirus Y142 protein----B-- DltD C-terminal region----B-- DltD N-terminal regionEM----- Phospholipase B----B-- Bacterial shufflon protein, N-terminal constant region----B-- DltD central region------V Family of unknown function (DUF656) EMF---- XAP5 proteinEMF---- DIE2/ALG10 familyEM----- Ninjurin ------V Poxvirus A6 protein EMF---- SHQ1 proteinEMF---- Poly(A) polymerase predicted RNA binding domainE--P--- Seed maturation proteinEMF---- Poly(A) polymerase central domain------V Herpes DNA replication accessory factor EMF--A- FUN14 familyEMF---- DNA polymerase phi----B-- O-Antigen ligaseEMF---- MED6 mediator sub complex componentEMF---- Surfeit locus protein 6

Protein of unknown function (DUF658)Protein of unknown function (DUF 659)

EMF---- Survival motor neuron (SMN) interacting protein 1 (SIP1)EMFP--- Ribosome biogenesis regulatory protein (RRS1)E---B-- Sensors of blue-light using FADEM----- CC domain------V Poxvirus F11 proteinEM--B-- YHS domain------V Poxvirus Late Transcription Factor VLTF3 like ------V Poxvirus A51 protein EM----- Family of unknown function (DUF662) EMF---- Protein of unknown function (DUF663)EM--B-- Succinylglutamate desuccinylase / Aspartoacylase family----B-- Siderophore-interacting protein

Sheet1

----B-- TrbC/VIRB2 family----B-- Ribosome modulation factorEMF---- Arsenite-resistance protein 2EM--B-- GlutaminaseEM--B-- Formiminotransferase-cyclodeaminase----B-- KduI/IolB family----B-- Sigma-54 factor, core binding domain

Flp/Fap pilin component----B-V Gene 25-like lysozyme-----A- HTH DNA binding domainEM----- CHORD EMFP--- CS domainEM----V NC domain----B-V Lysis protein S ----B-- Putative phospholipid-binding domain----B-- Septum formation initiator----B-- Protein of unknown function (DUF664)EMF---- Protein phosphatase inhibitor 2 (IPP-2)EMF--A- NMD3 family

HPP familyEMFPBAV RNA polymerase Rpb1, domain 3----B-V Phage tail sheath protein------V Phage tail tube protein FII----B-- Putative transposaseEMF---- Phosphatidylinositolglycan class N (PIG-N)EM----- A-kinase anchoring protein 95 (AKAP95)----B-V Cephalosporin hydroxylaseEMFP--V RNA polymerase Rpb1, domain 7EMF-B-- LICD Protein FamilyEMFP--V RNA polymerase Rpb1, domain 6----B-- TfoX C-terminal domain----B-- Heme exporter protein D (CcmD)EMFPBAV RNA polymerase Rpb1, domain 1EMFPBAV RNA polymerase Rpb1, domain 5----B-- Cell division protein FtsLEMFPBAV RNA polymerase Rpb1, domain 4EMFP--- RNA polymerase Rpb1 C-terminal repeat EMF---- SGS domain

Protein of unknown function (DUF668)EMF---- Interferon-related developmental regulator (IFRD)EM----- Janus/Ocnus family (Ocnus)------V Protein of unknown function (DUF666)EMFP--- Mannosyltransferase (PIG-M)EMFP--- Vesicle transport v-SNARE protein N-terminus------V Epstein-Barr virus nuclear antigen 3 (EBNA-3)EMF---- Transforming acidic coiled-coil-containing protein (TACC)EMFP--- Lariat debranching enzyme, C-terminal domainEMF-BA- Nucleoside 2-deoxyribosyltransferase----B-- Plasmid maintenance system killer protein----BA- Plasmid stabilisation system proteinEM----- Protein of unknown function (DUF667)EMFP--- Coenzyme Q (ubiquinone) biosynthesis protein Coq4EMF---- NPL4 family, putative zinc binding regionEMFP--- NPL4 familyEMF---- SRP40, C-terminal domainE-FP--- Phytochelatin synthaseEMF---- N-acetylglucosaminyl transferase component (Gpi1)

Sheet1

EM--B-- RbsD / FucU transport protein familyEMF---- Dcp2, box A domainEM-P--- Poly (ADP-ribose) glycohydrolase (PARG)EMF---- Timeless protein C terminal regionEM----- SSXT protein (N-terminal region)----B-- Iron Transport-associated domain EMFP--- Pre-SET motif----B-- Sporulation related domainEM----- Cytochrome Cytochrome b558 alpha-subunitEM----- Agouti proteinEM----- Pecanex protein (C-terminus)

Caleosin related protein----B-- Mga helix-turn-helix domainEM----- Homeobox prospero-like protein (PROX1)EMF---- Mitochondrial large subunit ribosomal protein (Img2)EMF---- Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain ----BA- Periplasmic copper-binding protein (NosD)EM----- Interferon-inducible GTPase (IIGP)EMF---- Cytochrome C oxidase copper chaperone (COX17)----B-- MerE proteinEM----- Menin------V Protein of unknown function (DUF673)E--P--- Protein of unknown function (DUF677)

Protein of unknown function (DUF674)EMF---- Putative serine esterase (DUF676)----B-- ActA ProteinEM----- N-acetylglucosaminyltransferase II (MGAT2)------V Poxvirus A11 ProteinE-F-B-- RICH domainEMFPB-- MT-A70 EMF---- Nsp1-like C-terminal region----B-V Phage capsid family ----B-- DNA-directed RNA polymerase delta subunit----B-- Manganese containing catalase----B-- Mannitol repressor----BAV Phage virion morphogenesis family EM-PB-- NADH ubiquinone oxidoreductase subunit NDUFA12------V Herpesvirus UL43 protein------V Baculovirus P24 capsid protein

Protein of unknown function (DUF684)EM--B-- Suppressor of fused protein (SUFU)------V Protein of unknown function (DUF678)------V Protein of unknown function (DUF682)----B-- Protein of unknown function (DUF683)EM----- LST-1 proteinE------ Granule antigen protein (GRA6)E------ Dictyostelium (Slime Mold) REP protein------V Rotavirus VP2 proteinE-F---- Bacterial NAD-glutamate dehydrogenaseEM----- Alpha-N-acetylglucosaminidase (NAGLU)EM--B-- Vitamin K-dependent gamma-carboxylaseEMFP--- Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)------V Protein of unknown function (DUF686)EMF---- Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis

Protein of unknown function (DUF687)E--P--- Glutamine cyclotransferaseE--P--- Protein of unknown function (DUF688)

Sheet1

------V Late expression factor 4 (LEF-4)----B-- Tellurite resistance protein TerB------V Phage minor tail protein L ----B-- Type IV secretory pathway, VirB3-like protein

holin, BlyA family----B-- DivIVA proteinEM----- Ribosome receptor lysine/proline rich region----B-V Holin family ----B-V Phage holin family (Lysis protein S)

Family of unknown function (DUF694) Protein of unknown function (DUF690)

------V Herpes virus major outer envelope glycoprotein (BLLF1)EM----- AF-4 proto-oncoproteinEM----- Ameloblastin precursor (Amelin)----B-- Protein of unknown function (DUF692)E--PB-- Cytochrome B6-F complex subunit VI (PetL)E--PB-- Sucrose-6F-phosphate phosphohydrolase----B-- Family of unknown function (DUF695) EM----V Aspartyl/Asparaginyl beta-hydroxylase

Phage terminase, small subunitGas vesicle protein G

----BA- Gas vesicle protein K -----A- S-layer like family, N-terminal region -----A- S-layer like family, C-terminal region EMFPB-V Putative ATPase (DUF699)----B-- Domain of unknown function (DUF697) EMFP--- Transcription elongation factor Elf1 like----B-- FlgN proteinEMF---- Pep3/Vps18/deep orange familyEMF---- RNA polymerase III RPC4----B-- General secretion pathway protein L (GspL)

Phage QLRG family, putative DNA packaging ------V Phage portal protein, lambda family ----B-- Fimbrial assembly protein (PilN)----B-- Phenylacetic acid catabolic protein----B-- Erythromycin esteraseE--PB-- ResB-like family E-F---- Pyoverdine/dityrosine biosynthesis protein

Domain of unknown function (DUF702) ------V Phage replication protein CRI EM--B-- Lanthionine synthetase C-like proteinEMF---- Hypothetical methyltransferaseE------ Paraflagellar rod protein

Legionella pneumophila major outer membrane protein precursorE--PB-- Photosystem II reaction centre M protein (PsbM)EM-P--- Family of unknown function (DUF706) EM--BA- TM2 domain------V Phage X family ----B-- GSPII_E N-terminal domainEMF---- RNA polymerase Rpc34 subunit----B-- Capsule polysaccharide biosynthesis proteinEMFP--- DSS1/SEM1 familyEM--B-- MOFRL familyEMFP-A- Ribosomal protein L41----B-- DinB family----B-- Cell division protein ZapAEM--BA- HEPN domain

Sheet1

----B-- Haemin-degrading HenS.ChuX domainEMF---- MPPN (rrm-like) domainE--PBA- Dihydrodipicolinate reductase, C-terminus

Cysteine-rich D. radiodurans N terminusEMFPBA- Methyltransferase small domainE-F---- ATP10 proteinEMF---- KRI1-like familyEMF---- RNA pol II accessory factor, Cdc73 familyEMF--A- DNL zinc fingerEMF---- XPA protein C-terminusEMF---- Fip1 motifEM-P--- Saposin-like type B, region 1EMFP--- PRMT5 arginine-N-methyltransferaseEMF---- Dpy-30 motifEMF-B-- Electron transfer flavoprotein-ubiquinone oxidoreductaseEMFPBA- MutS domain IIEMFPBA- RNA 3'-terminal phosphate cyclase (RTC), insert domainEMFPBA- MutS family domain IVEMFPBA- Adenylate kinase, active site lidEMFPBAV MutS domain IIIEMFPB-V Peptidase M16 inactive domain----B-- UreE urease accessory protein, C-terminal domainEMF-B-- Aminopeptidase P, N-terminal domainEM----- PTN/MK heparin-binding protein family, N-terminal domainEM----- TRIC channelEM--B-- Translation initiation factor IF-3, N-terminal domainEMFPB-V GMC oxidoreductaseE-F-B-- Hom_end-associated HintEMF---- COMPASS (Complex proteins associated with Set1p) component shg1EMF---- Methyltransferase TRM13EMF---- CSL zinc fingerEMF---- ALG3 protein----B-- Septum formation inhibitor MinC, N-terminal domainEM----- Sprouty protein (Spry)----B-- Neuraminyllactose-binding hemagglutinin precursor (NLBH)

Protein of unknown function (DUF707)EMF---- UNC-50 familyEM----- STOP protein

Protein of unknown function (DUF713)EM----- DREV methyltransferase----B-- MgpC protein precursorEMFPBA- S-adenosyl-L-homocysteine hydrolaseEMFPB-- Alanine dehydrogenase/PNT, N-terminal domain----B-- NTF2-like N-terminal transpeptidase domainEMF---- NDT80 / PhoG like DNA-binding familyEM--B-- helix-turn-helix, Psq domain

CHASE2 domainCHASE3 domainCHASE4 domain

----B-- MASE2 domain----B-- MASE1

Bacterial Transmembrane Pair family----B-- PHB accumulation regulatory domain----B-- CHAD domainEMF---- Transcription initiation factor TFIID component TAF4 familyEMFPB-- MoeZ/MoeB domainEMF---- Kinetochore protein CHL4 like

Sheet1

----BA- PRC-barrel domainEM-P--- Emopamil binding protein EM----- Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1)

Brucella outer membrane protein 2Protein of unknown function (DUF735)

EM----- Uncharacterised protein family (UPF0193)EM----- Uncharacterised protein family (UPF0197)EMF---- U11-48K-like CHHC zinc fingerEMFP--- Uncharacterised protein family (UPF0203)EMF---- Uncharacterised protein family (UPF0220)----B-- Uncharacterised protein family (UPF0223)E---B-- CHAP domain----B-- Protein of unknown function (DUF721)----B-- TraM protein

Borrelia P83/100 proteinProtein of unknown function (DUF722)Choristoneura fumiferana antifreeze protein (CfAFP)Protein of unknown function (DUF723)Protein of unknown function (DUF724)

EM----- Protein of unknown function (DUF725)------V Bacteriophage CII proteinEMF---- Alpha-L-arabinofuranosidase B (ABFB)

Virulence-associated protein E----B-- Copper resistance protein B precursor (CopB)EM----- SH3 domain-binding protein 5 (SH3BP5)EMF---- Protein of unknown function (DUF726)

Arabidopsis phospholipase-like protein (PEARLI 4)EM----- Aspartyl beta-hydroxylase N-terminal region----B-- Flagellar transcriptional activator (FlhC)EM----- Neuroendocrine protein 7B2 precursor (Secretogranin V)EMF---- AAR2 proteinEM----- Multi-glycosylated core protein 24 (MGC-24)----B-- Protein of unknown function (DUF736)EMF---- SDA1EM----- PMG protein------V Poxvirus A3L Protein

Borrelia hemolysin accessory protein------V Baculovirus immediate-early protein (IE-0)EMF---- BystinEM----- Malonyl-CoA decarboxylase (MCD)

African swine fever virus (ASFV) L11L proteinEM----- Scorpion short toxin

Luciferase/LBP N-terminal domainEM----- Mammalian taste receptor protein (TAS2R)------V Herpesvirus latent membrane protein 1 (LMP1)EM----- Bombinin

M61 glycyl aminopeptidaseEM----- Protein of unknown function (DUF737)EM----- Touch receptor neuron protein Mec-17EM----- Protein of unknown function (DUF727)------V Protein of unknown function (DUF728)----B-- Protein of unknown function (DUF732)

Protein of unknown function (DUF733)EM----- Protein of unknown function (DUF729)------V Baculovirus 33KDa late protein (PP31)------V Poxvirus P21 membrane protein------V Baculovirus occlusion-derived virus envelope protein EC27

Sheet1

E-F---- Mitochondrial ribosomal protein (VAR1)-----A- Thermopsin------V Poxvirus DNA-directed RNA polymerase 19 kDa subunit----B-- Haemolysin expression modulating protein------V NINE Protein------V Poxvirus A21 Protein

Protein of unknown function (DUF730)EM----- Seminal vesicle autoantigen (SVA)EMF---- RNA polymerase I specific transcription initiation factor RRN3EMFP--- CybS

Protein of unknown function (DUF742)------V Protein of unknown function (DUF743)EM----- Protein of unknown function (DUF719)

Protein of unknown function (DUF745)E---B-- Domain of unknown function (DUF718)EM----- Macrophage colony stimulating factor-1 (CSF-1)------V Protein of unknown function (DUF717)-----A- Protein of unknown function (DUF739)E--P--- Protein of unknown function (DUF740)------V Protein of unknown function (DUF708)----B-- M26 IgA1-specific Metallo-endopeptidase N-terminal region----BA- M42 glutamyl aminopeptidase

Domain of Unknown Function (DUF746)E-F---- Putative Ig domainEMF---- Eukaryotic membrane protein familyEMF---- Complex 1 protein (LYR family)EMFP--- Proteasome maturation factor UMP1EM----- Glycogen synthase kinase-3 bindingEM----- GMP-PDE, delta subunit------V Phage Connector (GP10)EM----- Delta Atracotoxin------V Phage Head-Tail AttachmentEM----- Apolipoprotein C-II------V Phage Coat Protein A----B-- DicB protein

Domain of Unknown Function (DUF748)----B-- yiaA/B two helix domainEM----- PKC-activated protein phosphatase-1 inhibitorEMFPBAV Lon protease (S16) C-terminal proteolytic domain------V Herpesvirus US12 family----B-- Salmonella type III secretion SopE effector N-terminusEMFP--- Ubiquinol-cytochrome C reductase, UQCRX/QCR9 likeEM----- Sarcolipin------V Phage endonuclease IEMFPB-- NmrA-like family-----A- Monomethylamine methyltransferase MtmB-----A- Domain of unknown function (DUF749)----B-- Delta lysin family

L-proline 3-hydroxylase, C-terminalEM----- Pacifastin inhibitor (LCMII)-----AV Flagella accessory protein C (FlaC)EMFPBA- Hydantoinase/oxoprolinase N-terminal region------V Carlavirus endopeptidase

Pao retrotransposon peptidase ------V Tymovirus endopeptidase

Bacteriophage peptidoglycan hydrolase EMF---- La domain

Sheet1

----B-- Sensor protein DegS------V Mastadenovirus early E4 13 kDa proteinEM----- TEP1 N-terminal domainEM----- Chorion family 3E-F---- Carboxypeptidase Y pro-peptide----B-- Negative regulator of genetic competence (MecA)E-F---- Yeast cell wall synthesis protein KRE9/KNH1EMF---- Lsm interaction motifEM----- Cytochrome C oxidase chain VIIB------V Human adenovirus early E3A glycoprotein----B-- Avirulence proteinEM----- Protein phosphatase inhibitor 1/DARPP-32------V Phage T7 capsid assembly proteinE-F---- Mediator complex subunit 15----B-- PufQ cytochrome subunitEM----- Ectropic viral integration site 2A protein (EVI2A)----B-- Flagellar protein FliT----B-- Nodulation protein S (NodS)EM----- Translocon-associated protein, delta subunit precursor (TRAP-delta)EMFP--- Mitochondrial ATP synthase B chain precursor (ATP-synt_B)EM-PB-- WGR domain------V Equine arteritis virus putative proteinase------V Equine arterivirus Nsp2-type cysteine proteinase------V Putative closterovirus papain-like endopeptidase------V Viral domain of unknown function (DUF1717)

Beet necrotic yellow vein furovirus-type papain-like endopeptidase------V Southampton virus-type processing peptidaseE--PB-- GUN4-like ----B-- Cellulose synthase operon protein C C-terminus (BCSC_C)E------ Protein of unknown function (DUF751)EMF---- Stress-activated map kinase interacting protein 1 (SIN1)----B-- Mycobacterium membrane proteinE------ Duffy binding domain----B-- Copper resistance protein D----B-- Alginate lyaseEM----- Acidic fibroblast growth factor binding (FIBP) EM----- Corticotropin-releasing factor binding protein (CRF-BP)EM----- Bone sialoprotein II (BSP-II)E-F-B-- Rickettsia 17 kDa surface antigenEM----- TMEM9------V Phi-29 DNA terminal protein GP3----BA- Branched-chain amino acid transport protein (AzlD)EM----- Thyrotropin-releasing hormone (TRH)EM----- Jumping translocation breakpoint protein (JTB)-----A- Tetrahydromethanopterin S-methyltransferase subunit B------V Microvirus A* protein------V Microvirus A protein----BA- ROS/MUCR transcriptional regulator protein

Protein of unknown function (DUF753)------V Poxvirus serine/threonine protein kinase----B-- Acetyl xylan esterase (AXE1)EM-P--- Nicastrin------V Phytoreovirus nonstructural protein Pns10/11EM----- BmTXKS1/BmP02 toxin familyEM----- Dystroglycan (Dystrophin-associated glycoprotein 1)EM----- Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)EMF---- Cd27 binding protein (Siva)

Sheet1

------V Herpesvirus transcriptional regulator familyEMFP--- Origin recognition complex subunit 6 (ORC6)EM----- Apolipoprotein LE------ Slime mold cyclic AMP receptorEM----- Sclerostin (SOST)------V Phi-29-like late genes activator (early protein GP4)-----A- Halobacterial gas vesicle protein C (GVPC) repeatEM----- Brain acid soluble protein 1 (BASP1 protein)------V Herpesvirus glycoprotein U47EMFP--- Eukaryotic translation initiation factor 3 subunit 8 N-terminus----B-- DNA replication terminus site-binding protein (Ter protein)EM----V UL45 protein----B-- Chlamydia virulence protein PGP3-DE-F---- PET122EM----- Surfeit locus protein 2 (SURF2)EM----- PromininE--P--- Photosystem I reaction centre subunit N (PSAN or PSI-N)----B-- Mycobacterium 19 kDa lipoprotein antigenEM----- Serendipity locus alpha protein (SRY-A)----B-- LRV protein FeS4 clusterEM----- THAP domainEMFP--- Signal recognition particle 9 kDa protein (SRP9)

PAAR motif------V Phage Tail Protein XEMF---- ATP synthase subunit H ----B-- Toluene tolerance, Ttg2 EMF---- CHY zinc finger----BA- Holliday junction DNA helicase ruvB N-terminusEM----- Destabilase

Rapid ALkalinization Factor (RALF) EMF---- DNA methyltransferase 1-associated protein 1 (DMAP1)EM----V Domain of unknown function (DUF755) EM----- Dynactin p62 family----B-- Spore germination B3/ GerAC like, C-terminal ------V Ebola nucleoprotein----B-- Domain of unknown function (DUF756)E-F---- RanGTP-binding protein----B-- TraY familyEM----- Sarcoglycan alpha/epsilonEM----- Mitochondrial ATP synthase coupling factor 6

AWPM-19-like family----B-- TraA

HR-like lesion-inducing ------V Viral nucleic acid binding EM----- p25-alpha

Totivirus coat proteinPhage head-tail joining protein WxcM-like, C-terminal

----B-- PEP-utilising enzyme, N-terminalRhodococcus equi virulence-associated protein

EM----- Domain of unknown function (DUF758) ------V Coronavirus gene 5 proteinEMF---- B-cell receptor-associated protein 31-like ------V Nucleopolyhedrovirus P10 protein----BA- CsbD-like

HicB familyEMFP--- Neurochondrin

Sheet1

Borrelia burgdorferi protein of unknown function (DUF759)----B-- Campylobacter major outer membrane protein------V Pneumovirinae attachment membrane glycoprotein G

Protein of unknown function (DUF760)----B-- Staphopain peptidase C47EM--B-- Proline racemase

Cbb3-type cytochrome oxidase component FixQE-F---- She9 / Mdm33 familyE--P--- Gametolysin peptidase M11------V Allexivirus 40kDa protein----B-- Conserved TM helix

Cotton fibre expressed proteinViral hemorrhagic septicemia virus non-virion protein

EM----- Calcineurin-binding protein (Calsarcin)EMF---- Mitotic checkpoint protein

Protein of unknown function (DUF763)Bacillus thuringiensis P21 molecular chaperone proteinBorrelia burgdorferi protein of unknown function (DUF764)

----B-- Salmonella plasmid virulence protein SpvDE--P--- Dormancy/auxin associated protein

Siphovirus Gp157------V Orthopoxvirus interleukin 18 binding protein------V African swine fever virus J13L protein----BA- BlaR1 peptidase M56

Circovirus protein of unknown function (DUF765)EM----- Protein of unknown function (DUF766)EM---AV Pregnancy-associated plasma protein-A----B-- NosL----B-- PS-10 peptidase S37EM----- Serine carboxypeptidase S28------V Equine arteritis virus serine endopeptidase S32----B-- SpoIVB peptidase S55

Vibrio chemotaxis protein N terminus----B-- YabG peptidase U57

Sulfolobus plasmid regulatory proteinPutative peptidase (DUF1758)

EM----- Anthrax receptor C-terminus regionEM----- Anthrax receptor extracellular domainEM--B-- Clostridium botulinum HA-17 protein

Protein of unknown function (DUF768)Xylella fastidiosa protein of unknown function (DUF769)Protein of unknown function (DUF770)Bacterial alpha-L-rhamnosidase

EM--B-- RHS RepeatDomain of unknown function (DUF771) Taeniidae antigenPoly(hydroxyalcanoate) granule associated protein (phasin)

EM--B-- Transposase domain (DUF772)EM-P--- Protein of unknown function (DUF773)EM----- Cleft lip and palate transmembrane protein 1 (CLPTM1)EMF---- Protein of unknown function (DUF775)EM----- Protein of unknown function (DUF776)EM-P--- Drought induced 19 protein (Di19)

Borrelia burgdorferi protein of unknown function (DUF777)EM----- Protein of unknown function (DUF778)EM----- Lamina-associated polypeptide 1C (LAP1C)

Caenorhabditis elegans protein of unknown function (DUF780)

Sheet1

EM----- Mouse protein of unknown function (DUF781)------V Human herpesvirus U15 protein------V Circovirus protein of unknown function (DUF782)EMF---- Tho complex subunit 7

Neisseria meningitidis TspB proteinProtein of unknown function (DUF784)Borrelia burgdorferi protein of unknown function (DUF787)

EMF---- Protein of unknown function (DUF788)Bacterial TniB protein

EM----- HOOK proteinEM----- Lipolysis stimulated receptor (LSR)EMF---- PAXNEB protein

Borrelia membrane protein P13Necrosis inducing protein (NPP1)

EM----- Protein of unknown function (DUF791)Borrelia burgdorferi protein of unknown function (DUF792)

E--P--- Protein of unknown function (DUF793)E--P--- Arabidopsis thaliana protein of unknown function (DUF794)

S23 ribosomal protein----BA- Protein of unknown function (DUF795)E-FP--- galactosyl transferase GMA12/MNN10 family

Pup-like proteinEM----- Na,K-Atpase Interacting proteinEM----- Agenet domain

Sporozoite P67 surface antigenEM----- Protein of unknown function (DUF800)EMF---- RNA polymerase III subunit RPC82

C. elegans protein of unknown function (DUF801)EMFP--- Peroxisomal biogenesis factor 11 (PEX11)EM--B-V Peptidase family M13

Domain of unknown function (DUF802)EMF---- Scavenger mRNA decapping enzyme (DcpS) N-terminalEM--B-- Protein of unknown function (DUF803)

Pseudomonas avirulence D protein (AvrD)----B-- Protein of unknown function (DUF805)E--P--- Arabidopsis broad-spectrum mildew resistance protein RPW8----B-- Coxiella burnetii protein of unknown function (DUF807)----B-- Protein of unknown function (DUF808)----B-- HaemagglutininE--P--- Protein of unknown function (DUF809)

Protein of unknown function (DUF810)Domain of unknown function (DUF811)

----B-- Fels-1 Prophage Protein-likeEM----- Protein of unknown function (DUF812)EMFP--- SOH1EMF--A- Domain of unknown function (DUF814)EM----- GETHR pentapeptide repeat (5 copies)EM----- MAP7 (E-MAP-115) family

Protein of unknown function (DUF815)------V Baculovirus protein of unknown function (DUF816)EM----- NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)EM----- Chlamydia CHLPS protein (DUF818)EM----- Chondroitin N-acetylgalactosaminyltransferaseEMF---- ATP synthase E chain----BA- Fumarate hydratase (Fumerase)----BA- Fumarase C-terminus

Protein of unknown function (DUF819)

Sheet1

EM--B-V Arabidopsis thaliana protein of unknown function (DUF821)E--P--- Plant protein of unknown function (DUF822)

Salmonella repeat of unknown function (DUF824)Salmonella repeat of unknown function (DUF823)

E---BA- Thiazole biosynthesis protein ThiGE--P-A- Raffinose synthase or seed inhibition protein Sip1

Mycoplasma haemagglutininEMF---- Glycogen synthaseEM-P--- 56kDa selenium binding protein (SBP56)E--P--- Plant protein of unknown function (DUF825)

Protein of unknown function (DUF826)----B-- Bacterial trigger factor protein (TF) C-terminusEM-P--- hAT family dimerisation domainEMF---- Breast carcinoma amplified sequence 2 (BCAS2)E--P--- Plant protein of unknown function (DUF827)------V Herpesvirus UL49.5 envelope/tegument protein

Plant protein of unknown function (DUF828)Capsular polysaccharide synthesis protein

EM----- Eukaryotic protein of unknown function (DUF829)EM----- Cyclin-dependent kinase inhibitor 3 (CDKN3)----B-V Zonular occludens toxin (Zot)----B-V Orthopoxvirus protein of unknown function (DUF830)----B-- Phage tail proteinE------ Coiled coilEMF---- MRG----B-- Bacterial mobilisation protein (MobC)

Borrelia burgdorferi virulent strain associated lipoproteinEM----- Piccolo Zn-fingerEM----- A-kinase anchor protein 110 kDa (AKAP 110)EMF---- Golgi phosphoprotein 3 (GPP34)E------ Cell-cell adhesion domainEMF-B-- Phytanoyl-CoA dioxygenase (PhyH)EMF-B-- Thiopurine S-methyltransferase (TPMT)E-----V FNIP Repeat-----A- Uncharacterised protein family (UPF0228)----B-- Uncharacterised protein family (UPF0227)EMF-BA- NACHT domainE-F---- CFEM domainEM--B-- TROVE domain----B-- Firmicute plasmid replication protein (RepL)------V Tenuivirus/Phlebovirus nucleocapsid proteinEM----- Thrombospondin C-terminal region----B-- Collagen binding domainE---B-- Cna protein B-type domainEMFP--- SNARE domainEM----- Nanos RNA binding domainEMF---- Protein of unknown function (DUF833)EMFP--- UEV domain----B-- Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA)EMF-BAV DALR anticodon binding domain------V Rubella membrane glycoprotein E1------V Rubella membrane glycoprotein E2------V Rubella capsid protein----B-- FixH------V Calicivirus minor structural proteinEM----- Translocon-associated protein beta (TRAPB)E--P--- Rubber elongation factor protein (REF)

Sheet1

E------ S-antigen proteinE--P--- Oxygen evolving enhancer protein 3 (PsbQ)E--P--- Ycf1EM----- Immediate early response protein (IER)EM----- 5' nucleotidase family----B-- VWA domain containing CoxE-like protein

Protein of unknown function (DUF835)EMF---- YL1 nuclear protein------V Bacteriophage Lambda NinG protein------V Poxvirus virion envelope protein A14EMF-B-V Glutaredoxin-like domain (DUF836)EM----- Protein of unknown function (DUF837)EM-P--- Inositol 1, 3, 4-trisphosphate 5/6-kinase------V Poxvirus A31 protein----B-V NinB proteinEMFP--- RWD domain------V Herpesvirus helicase-primase complex component----B-- Enterobacteria AfaD invasin protein------V Papillomavirus E5A proteinEM----- Drosophila accessory gland-specific peptide 26Ab (Acp26Ab)EM----- Apolipoprotein CIII (Apo-CIII)EM----- MRVI1 proteinEM----- Extracellular matrix protein 1 (ECM1)EMF---- Dynein light intermediate chain (DLIC)------V Betaherpesvirus UL82/83 protein N terminus

Rho-activating domain of cytotoxic necrotizing factorEMF---- Barren proteinEM----- Immunoglobulin C2-set domain----B-- Bacillus haemolytic enterotoxin (HBL)E-F---- Candida agglutinin-like (ALS)EMFP--- Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)EMF---- T-complex protein 11

Plasmodium vivax Vir protein------V Chordopoxvirus protein G2E-F---- Yeast trans-acting factor (REP1/REP2)------V Bacteriophage FRD3 proteinE--P--- Cytochrome c oxidase subunit Vc (COX5C)-----A- Gas vesicle synthesis protein GvpO------V Lagovirus protein of unknown function (DUF840)----B-- Enterobacterial EspB protein------V Chordopoxvirus L2 proteinEMFP--- Kinesin-associated protein (KAP)EM----- L6 membrane proteinEM----- NogginEM----- Podoplanin------V NinF proteinEM----- Eukaryotic protein of unknown function (DUF842)------V Herpesvirus BLRF2 protein------V Orthopoxvirus F7 protein------V Baculovirus protein of unknown function (DUF843)------V Baculovirus protein of unknown function (DUF844)----B-- Toxic anion resistance protein (TelA)EMF---- Oligosaccharyltransferase subunit Ribophorin II----B-- Enterobacterial TraT complement resistance protein------V Baculovirus protein of unknown function (DUF845)EM----- NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)EM----- Pyrimidine 5'-nucleotidase (UMPH-1)

Sheet1

EM----- Nematode fatty acid retinoid binding protein (Gp-FAR-1)EM----- Pro-melanin-concentrating hormone (Pro-MCH)EM----- Beta-microseminoprotein (PSP-94)EM----- Phospholipase A2EMF---- Vacuolar ATP synthase subunit S1 (ATP6S1)------V Adenovirus late L2 mu core protein (Protein X)----B-- Nodulation protein Z (NodZ)EM----- GAGE proteinEMFP--- Eukaryotic protein of unknown function (DUF846)EMF--A- Fibronectin-binding protein A N-terminus (FbpA)E--PB-- Lycopene cyclase proteinEM----- Synaphin proteinEM----- Chorion protein S16EMF---- Centromere protein H (CENP-H)EMF---- Apc13p proteinE------ Euplotes octocarinatus mating pheromone proteinEMF---- Suppressor of forked protein (Suf)----B-- YopD protein----B-- Bacterial phosphonate metabolism protein (PhnH)------V Chordopoxvirus A15 proteinEM----- Fibroin light chain (L-fibroin)------V Lentivirus virion infectivity factor (VIF)------V Gammaherpesvirus protein of unknown function (DUF848)-----A- Non-histone chromosomal protein MC1EMF---- ARP2/3 complex 20 kDa subunit (ARPC4)----B-- TraX protein------V Bovine immunodeficiency virus surface protein (SU)EMF---- Mis12 protein----B-- haemagglutination activity domain----B-- Bacterial phosphonate metabolism protein (PhnI)------V Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)----B-V Endodeoxyribonuclease RusA

Caenorhabditis elegans repeat of unknown function (DUF851)------V Rotavirus major outer capsid protein VP7----B-V DNA N-6-adenine-methyltransferase (Dam)----B-- Phenolic acid decarboxylase (PAD)EMFP--- ESCRT-II complex subunit----BA- Bacterial protein of unknown function (DUF853)EMFP--- ATP synthase D chain, mitochondrial (ATP5H)EM----- Pheromone biosynthesis activating neuropeptide (PBAN)EMF---- Alkaline phytoceramidase (aPHC)----B-V Phage terminase large subunit (GpA)------V Phytoreovirus nonstructural protein Pns9/Pns10EMF---- Root hair defective 3 GTP-binding protein (RHD3)EM----- 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)------V Baculovirus U-box/Ring-like domain

Interactor of ZYG-11------V Orthopoxvirus F8 proteinE------ Procyclic acidic repetitive protein (PARP)EM---A- Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen)EMFP--- Eukaryotic rRNA processing protein EBP2EMF---- Putative hydroxyindole-O-methyltransferase------V Trichovirus coat protein----B-- Acyl-CoA reductase (LuxC)

Siphovirus protein of unknown function (DUF859)----B-- Na(+)-translocating NADH-quinone reductase subunit A (NQRA)----B-- Protein of unknown function (DUF861)

Sheet1

----B-- Excalibur calcium-binding domainEM----- 4.1 protein C-terminal domain (CTD)EMFP--V PPPDE putative peptidase domain

Herpesvirus-7 repeat of unknown function (DUF865)EMF---- Eukaryotic protein of unknown function (DUF866)

Plant protein of unknown function (DUF868)E--P--- Plant protein of unknown function (DUF869)EM----- Caenorhabditis elegans protein of unknown function (DUF870)EM----- RIB43AEM----- Eukaryotic protein of unknown function (DUF872)EMFP--- GINS complex subunit Sld5

Helicobacter pylori protein of unknown function (DUF874)EM----- Apoptosis inhibitory protein 5 (API5)E--P--- Mitovirus RNA-dependent RNA polymeraseEMFP--- Coprinus cinereus mating-type proteinEMFPB-- Peptidase inhibitor I9EM----- APC cysteine-rich regionEM----- SAMP Motif------V Phage head completion protein (GPL)EM----- Penaeidin

Zea mays MURB-like protein (MuDR)------V Phage capsid scaffolding protein (GPO) serine peptidase----B-V Prophage CP4-57 regulatory protein (AlpA)

Staphylococcal AgrD proteinE-F---- Fungal ATP synthase protein 8 (A6L)EM----- Mid-1-related chloride channel (MCLC)

Arylsulfotransferase (ASST)Bacterial protein of unknown function (DUF876)

------V Phage minor tail protein------V Chordopoxvirus A20R protein----B-- Toxin-coregulated pilus subunit TcpA----B-- Bacterial protein of unknown function (DUF881)------V Orthopoxvirus A36R protein----B-- Bacterial protein of unknown function (DUF882)----B-- Bacillus competence pheromone ComXEM----- Allatostatin----B-V Phage late control gene D protein (GPD)------V Equine herpesvirus glycoprotein gp2EM----- APC basic domain----B-- Bacterial protein of unknown function (DUF883)EMFPBAV tRNA (Uracil-5-)-methyltransferase------V Nucleopolyhedrovirus protein of unknown function (DUF884)

Bacterial protein of unknown function (DUF885)------V Chordopoxvirus A13L protein----B-- HutDEM-P--- F/Y-rich N-terminusEM-P--- F/Y rich C-terminus------V Chordopoxvirus A33R protein

Bacillus PapR proteinEMF---V PIF1 helicaseEMF-BA- Protein of unknown function (DUF890)EM----- APC 15 residue motif----B-- Phage derived protein Gp49-like (DUF891)----B-- Domain of unknown function (DUF892)----B-- Bacterial ABC transporter protein EcsBE-F-B-- Bacterial protein of unknown function (DUF894)EMFPB-- Ion channel regulatory protein UNC-93

Sheet1

----B-- Bacterial protein of unknown function (DUF896)EM----- Toxin 7

Domain of unknown function (DUF897) EMF---- MED7 protein------V Cytomegalovirus UL20A proteinEM----- ADAM-TS Spacer 1----B-- Bacterial protein of unknown function (DUF898)

Bacterial protein of unknown function (DUF899)----B-- Alpha/beta hydrolase of unknown function (DUF900)----B-- Protein of unknown function (DUF901)EM-P--- Cytoplasmic Fragile-X interacting familyEMF-B-- Cysteine dioxygenase type IE--PB-V Ferredoxin-dependent bilin reductaseEMF---- Nucleolar protein,Nop52------V Herpesvirus U5-like familyEM----- Domain of Unknown Function (DUF902)----B-- Alpha-2,3-sialyltransferase (CST-I)EM----- Survival motor neuron protein (SMN)----B-- Bacterial protein of unknown function (DUF903)----B-- Protein of unknown function (DUF904)----B-- Phosphonate metabolism protein PhnJEM----- Laminin Domain IEM----- Laminin Domain IIE-F---- Transient receptor potential (TRP) ion channelEMFP--- Domain of Unknown Function (DUF908)----B-- Proteins of 100 residues with WXG----B-- Bacterial protein of unknown function (DUF910)------V Chordopoxvirus A30L proteinEMF---- Myosin tail----B-- CodY GAF-like domain------V Phage GP30.8 proteinEM----- Drosophila roughex proteinEM----- Aralkyl acyl-CoA:amino acid N-acyltransferase

Plasmodium variant antigen protein Cir/Yir/BirArchaeal protein of unknown function (DUF911)

------V Nucleopolyhedrovirus protein of unknown function (DUF912)EMFP--- Domain of Unknown Function (DUF913)EMFPBA- Ribose 5-phosphate isomerase A (phosphoriboisomerase A)EMF---- Eukaryotic protein of unknown function (DUF914)

Alpha/beta hydrolase of unknown function (DUF915)----B-- AlkA N-terminal domain

Bacterial protein of unknown function (DUF916)EM----- SERTA motif------V Nucleopolyhedrovirus protein of unknown function (DUF918)

Bacterial protein of unknown function (DUF920)Bacterial protein of unknown function (DUF922)

----B-- Malate:quinone oxidoreductase (Mqo)------V Adenovirus E3 protein

Bacterial protein of unknown function (DUF924)Bacterial protein of unknown function (DUF925)

----B-- Dam-replacing familyEMF---- Exocyst complex component Sec6EMF---- Ras-induced vulval development antagonist

Domain of unknown function (DUF927)----BA- 2-hydroxyglutaryl-CoA dehydratase, D-component

Domain of Unknown Function (DUF928)Domain of unknown function (DUF929)

Sheet1

Competence protein CoiA-like family----B-- Exopolysaccharide synthesis, ExoD------V Putative ATPase subunit of terminase (gpP-like)

Bacterial virulence protein (VirJ)EMFP--- Dcp1-like decapping family

Domain of Unknown Function (DUF930)EM----- Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)------V Baculoviridae ME53----B-- Uncharacterised protein family (UPF0231)----B-- Domain of unknown function (DUF932)EMF---- TIP49 C-terminus----B-- PerC transcriptional activator------V Herpesvirus large structural phosphoprotein UL32EMF-B-- Protein of unknown function (DUF933)------V Alphaherpesvirus tegument protein US9----B-V Protein of unknown function (DUF935)

Plant protein of unknown function (DUF936)----B-- Bacterial protein of unknown function (DUF937)EM----- ApyraseEM----- Protein of unknown function (DUF938)----B-- Bacterial protein of unknown function (DUF939)----B-- Bacterial putative lipoprotein (DUF940)EM----V Interleukin-17------V Cytomegalovirus TRL10 proteinEM--B-V Lipoprotein Rz1 precursorEMF---- Tyrosyl-DNA phosphodiesterase------V Nucleopolyhedrovirus telokin-like protein-20 (TLP20)EMFP--- Inositol-pentakisphosphate 2-kinase

Enterobacterial putative membrane protein (DUF943)EMFP-A- Spt4/RpoE2 zinc fingerEM-PBA- AIG2-like family------V Baculoviridae 8.2 KDa protein----B-- Bacterial protein of unknown function (DUF945)EM-P--- Radial spoke protein 3

Streptococcal 67 kDa myosin-cross-reactive antigen like family E-F---- Plant protein of unknown function (DUF946)EMF---- Domain of unknown function (DUF947)----B-- Bacterial protein of unknown function (DUF948)EM-P--- Aph-1 protein

Bacterial protein of unknown function (DUF951)EMF---- Eukaryotic protein of unknown function (DUF953)------V Gammaherpesvirus capsid proteinEM----- Brain and reproductive organ-expressed protein (BRE)----B-V Domain of unknown function (DUF955)

Domain of unknown function (DUF956)------V Transcriptional activator RinB

Enterobacterial protein of unknown function (DUF957)EM----- Nidogen-likeEM----- Domain of Unknown Function (DUF959) ----B-- Conjugative relaxosome accessory transposon protein----B-- Inner membrane protein CreD

Staphylococcal protein of unknown function (DUF960)Herpesvirus Latent membrane protein 2

E-F---- Protein of unknown function (DUF962)Shigella flexneri OspC protein

E-F--A- Schizosaccharomyces pombe repeat of unknown function (DUF963)----B-- Protein of unknown function (DUF964)

Sheet1

----B-- Bacterial protein of unknown function (DUF965)Domain of unknown function (DUF966)

----B-- BphX-likeEM----- Interferon-induced 6-16 family ------V Baculovirus 11 kDa family----BA- DNA polymerase III, delta subunit------V Coronavirus nonstructural protein NS1----B-V Protein of unknown function (DUF968)EMF---- COG (conserved oligomeric Golgi) complex component, COG2----B-V ChaBEM----- Trehalose receptor------V Phage minor capsid protein 2----B-- Protein of unknown function (DUF970)EMF-B-- Protein of unknown function (DUF971)----B-- Protein of unknown function (DUF972)

Protein of unknown function (DUF973)Phage tail protein E

EM----- Protein of unknown function (DUF974)----B-- Septation ring formation regulator, EzrA

Protein of unknown function (DUF975)Caenorhabditis elegans protein of unknown function (DUF976)Bacterial protein of unknown function (DUF977)

----B-- Glycosyltransferase family 36----B-- Phosphoenolpyruvate:glucose-phosphotransferase regulator

Protein of unknown function (DUF981)Protein of unknown function (DUF982)Protein of unknown function (DUF983)

E-F---- Cupin superfamily (DUF985)----B-- Lipopolysaccharide core biosynthesis protein (WaaY)

QueT transporter----B-- Oligogalacturonate-specific porin protein (KdgM)EMF---- Surfeit locus protein 5 subunit 22 of Mediator complex----B-- Cobalt chelatase (CbiK)----B-V DinI-like family----B-- YecM protein----B-- HrpE proteinEM----- 5'-nucleotidase------V Orthopoxvirus A5L protein-like

Phage Conserved Open Reading Frame 51-----A- Protein of unknown function (DUF996)----B-- Protein of unknown function (DUF997)

Protein of unknown function (DUF998)E-F---- Protein of unknown function (DUF999)

Phage major tail protein 2E--P--- tify domainEMFP--- C-terminal proteasome-interacting domain of thioredoxin-likeEMF---- Amylo-alpha-1,6-glucosidase E--P--- CCT motif----B-- Putative carbohydrate binding domain ----B-- CpeT/CpcT family (DUF1001)----B-- Protein of unknown function (DUF1002)EM----- Cofactor of BRCA1 (COBRA1)

Protein of unknown function (DUF1003)EM----- BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domainEM----- GRIM-19 protein----B-- Cobalamin biosynthesis protein CobTEM----- Signaling lymphocytic activation molecule (SLAM) protein

Sheet1

------V Rice tungro bacilliform virus P46 proteinE-F---- GAGA binding protein-like familyEMF---- Nitrogen permease regulator 2EMFP--- U1 zinc fingerEMF---- Putative zinc finger motif, C2HC5-type

Phage tail assembly chaperone------V Minor tail protein T----B-- Protein of unknown function (DUF1007)------V Orthopoxvirus N1 proteinEMF---- FRG1-like family

Protein of unknown function (DUF1009)Protein of unknown function (DUF1010)Embryo-specific protein 3, (ATS3)

----B-- Toluene-4-monooxygenase system protein B (TmoB)----B-- Tyrosinase co-factor MelC1EM----- Protein of unknown function (DUF1011)

Borrelia burgdorferi BBR25 lipoproteinEM----- Evolutionarily conserved signalling intermediate in Toll pathway

Carbon monoxide dehydrogenase subunit G (CoxG)E--P--- Protein of unknown function (DUF1012)

Protein of unknown function (DUF1013)EMF---- Protein of unknown function (DUF1014)EMF---- Isy1-like splicing familyE------ Plasmodium ookinete surface protein Pvs28EM-P--- Centromere/kinetochore Zw10----B-- Ethanolamine utilisation protein EutQ----B-- SLBB-domain like (DUF1017)----B-V Protein of unknown function (DUF1018)----BA- Trimethylamine methyltransferase (MTTB)----B-V Protein of unknown function (DUF1019)

Protein of unknown function (DUF1020)------V Nucleopolyhedrovirus LEF-12 protein----B-- Protein of unknown function (DUF1021)----B-- Protein of unknown function (DUF1022)----B-- Alpha/beta hydrolase of unknown function (DUF1023)

Protein of unknown function (DUF1024)Actinobacillus actinomycetemcomitans leukotoxin activator LktCDomain of unknown function (DUF1025)Protein of unknown function (DUF1027)HrpF protein

EM----- Fascin domainProtein of unknown function (DUF1030)

EM--B-- RDD familyPlant specific eukaryotic initiation factor 4BProtein of unknown function (DUF1031)

----B-- Ferric iron reductase FhuF-like transporter----B-- Ethanolamine utilisation protein EutAEM----- Protein of unknown function (DUF1032)

Protein of unknown function (DUF1033)----B-- Fn3-like domain (DUF1034)

Protein of unknown function (DUF1036)------V Cytomegalovirus UL84 protein

Protein of unknown function (DUF1039)----B-- Protein of unknown function (DUF1040)

Flagellar protein (FlbD)EM----- Domain of Unknown Function (DUF1041)EMF-BA- Lipopolysaccharide kinase (Kdo/WaaP) family

Sheet1

EM----- Domain of Unknown Function (DUF1042)----B-- Protein of unknown function (DUF1043)EM----- PET DomainE--PB-- Photosystem II protein Y (PsbY)

Protein of unknown function (DUF1045)------V Bacteriophage lambda Kil protein----B-- Organiser of macrodomain of Terminus of chromosome

Protein of unknown function (DUF1048)EM--B-- Protein of unknown function (DUF1049)------V Herpesvirus IR6 proteinEM----- TorsinEM----- NUMB domainEM----- NeurexophilinEM----- Drosophila ACP53EA protein

Protein of unknown function (DUF1052)EM-P--- GCN5-like protein 1 (GCN5L1)------V Phage NinH protein------V Phage antitermination protein QEM----- Pigment-dispersing hormone (PDH)EMFPBA- Ribosomal protein L11 methyltransferase (PrmA)EM----- Domain of Unknown Function (DUF1053)EM----- Ig-like C2-type domainE-F---- Trichodiene synthase (TRI5)EMF---- Transcription factor TFIIH complex subunit Tfb5EMF---- Mediator complex subunit 13 C-terminal------V Orthopoxvirus A47 protein----B-- Protein of unknown function (DUF1054)EMFP--- DUSP domain----B-- ComK protein----B-- Ectoine synthase

Protein of unknown function (DUF1056)EM----- Alpha/beta hydrolase of unknown function (DUF1057)------V Parechovirus Genome-linked proteinEM----- DRF Autoregulatory DomainEM----- Formin Homology Region 1

Bacterial SH3 domainProtein of unknown function (DUF1059)

EM----- Hormone-sensitive lipase (HSL) N-terminusProtein of unknown function (DUF1062)Protein of unknown function (DUF1064)

EM----- Omega-atracotoxinProtein of unknown function (DUF1065)

------V Picornaviridae P3A proteinProtein of unknown function (DUF1068)

EM----- CD34/Podocalyxin familyEMF---- Diaphanous FH3 DomainEM----- Sea anemone cytotoxic proteinEMF---- Diaphanous GTPase-binding DomainEM----- Gemin6 proteinEM----- Cocaine and amphetamine regulated transcript protein (CART)EM----- NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2)EM----- Bovine leukaemia virus receptor (BLVR)E--P--- Protein of unknown function (DUF1070)EM----- Adipokinetic hormone----B-- L-rhamnose-proton symport protein (RhaT)------V Protein of unknown function (DUF1072)


Sheet1

EM----- Beta-catenin-interacting protein ICAT------V Baculovirus LEF-11 protein----BA- Gas vesicle synthesis protein GvpL/GvpFEM----- D1 dopamine receptor-interacting protein (calcyon)EM----- Protein of unknown function (DUF1075)EM----- Neuroendocrine-specific golgi protein P55 (NESP55)EMF---- CDK-activating kinase assembly factor MAT1----B-- Acid shock protein repeat EM----- BH3 interacting domain (BID)EM----- Pepsin inhibitor-3-like repeated domainE-F---- CDC24 CalponinEM----- Angiotensin II, type I receptor-associated protein (AGTRAP)----BA- Desulfoferrodoxin, N-terminal domainEMF---- Integral peroxisomal membrane peroxinEM----- GTP cyclohydrolase I feedback regulatory protein (GFRP)EM----- Alpha-2-macroglobulin RAP, N-terminal domainEM----- Alpha-2-macroglobulin RAP, C-terminal domain EM----- LamprinE--P--- Phytosulfokine precursor protein (PSK)E--P--- Red chlorophyll catabolite reductase (RCC reductase)----B-- StbA proteinEM----V Borna disease virus P40 proteinEM----- Nuclear pore complex interacting protein (NPIP)----B-- hns-dependent expression protein A (HdeA)----B-- Conjugal transfer protein TraDEMF---- NeugrinEMF-BAV Zeta toxinE--PBA- BPG-independent PGAM N-terminus (iPGM_N)EMF---- Protein of unknown function (DUF1077)EMF-BA- CTP synthase N-terminusEMF---- Conserved oligomeric complex COG6E-F---- Mitochondrial genome maintenance MGM101EMF-B-- GTP-binding protein LepA C-terminusE-F---- CDR ABC transporterEMFP--- GWT1EMF---- PRP1 splicing factor, N-terminalE-FPB-- Serine acetyltransferase, N-terminal EMF---- UDP-glucose:Glycoprotein GlucosyltransferaseEMF---- GDP/GTP exchange factor Sec2p

Lactococcus lactis RepB C-terminus------V Polyomavirus large T antigen C-terminusEMF---- Phosphatidylinositol N-acetylglucosaminyltransferase----B-- Methylamine dehydrogenase heavy chain (MADH)

Repeat of unknown function (DUF1079)------V Pneumovirus matrix protein 2 (M2)E-F---- IMP-specific 5'-nucleotidase----BA- Domain of Unknown Function (DUF1080)----B-- DNA polymerase III, theta subunitEM--B-- Epoxide hydrolase N terminus----B-- R67 dihydrofolate reductaseEM----- NADH dehydrogenase subunit 2 C-terminusEM----- HepcidinEM----- Domain of Unknown Function (DUF1081)E--P--- Mitochondrial domain of unknown function (DUF1082)EM----- Moricin----B-- Domain of unknown function (DUF1083)----B-- Type II heat-labile enterotoxin , B subunit (LT-IIB)

Sheet1

Protein of unknown function (DUF1084)EMFP--- NADH dehydrogenase subunit 5 C-terminusEM----- Arfaptin-like domainEM----- EctatominEM----- Ryanodine Receptor TM 4-6------V Coronavirus NSP13EM-P--- Domain of Unknown Function (DUF1086)EM----- PropellerEM-PBA- Molybdenum Cofactor Synthesis CEMF---- DMAP1-binding DomainEM-P--- Domain of Unknown Function (DUF1087)EM----- PCAF (P300/CBP-associated factor) N-terminal domainEM----V MYM-type Zinc finger with FCS sequence motifEM----- Spondin_NEM----- Domain of Unknown Function (DUF1088)EMFPBA- SMC proteins Flexible Hinge Domain------V NSP11EMFPB-- ABC transporter transmembrane region 2----B-- MLTD_N


Protein of unknown function (DUF1091)EMF---- Ribonuclease 2-5AEMFPB-- FtsH Extracellular----B-- COX Aromatic Rich MotifEM----- Collagenase NC10 and EndostatinEMFP--- Sin3 associated polypeptide p18 (SAP18)------V Orthopoxvirus A49R protein

Flagellar regulatory protein FleQ----B-- Protein of unknown function (DUF1094)

Protein of unknown function (DUF1096)EM----- Fruit fly transformer protein------V Protein of unknown function (DUF1098)----B-- Alpha/beta hydrolase of unknown function (DUF1100)

Equine infectious anaemia virus S2 protein------V Protein of unknown function (DUF1101)

Replication protein C (RepC)----B-- Activator of aromatic catabolism----B-- Propionate catabolism activatorE--P--- Auxin response factor----BA- ExsBEM----- Sodium ion transport-associated

Repeat of unknown function (DUF1103)E---B-- Photosystem II 12 kDa extrinsic protein (PsbU)E-F---- Purine nucleoside permease (NUP)

Protein of unknown function (DUF1104)PAR1 protein

E-F---- B12D proteinProtein of unknown function (DUF1106)

EM----- NOA36 protein----BA- Sulfocyanin (SoxE)----B-- Protein of unknown function (DUF1107)

Phage P2 GpEEM----- Vertebrate interleukin-3 regulated transcription factor----B-V Phage antitermination protein Q


Sheet1

Protein of unknown function (DUF1110)EM----- Repulsive guidance molecule (RGM) C-terminusEM----- Repulsive guidance molecule (RGM) N-terminusEM----- Galanin message associated peptide (GMAP)

Regulator protein PHA-1Lactococcus bacteriophage repressor

EMF---- Protein of unknown function (DUF1115)----B-- Protein of unknown function (DUF1116)EM----- Vertebrate heat shock transcription factor

Protein of unknown function (DUF1117)Kinesin-relatedProtein of unknown function (DUF1118)Protein of unknown function (DUF1119)

----B-- Protein of unknown function (DUF1120)E--P--- Plant specific mitochondrial import receptor subunit TOM20EM----- BNIP3EM----- Olfactory marker protein------V IAP-like protein p27 C-terminus

Protein of unknown function (DUF1122)----B-- Secretion monitor precursor protein (SecM)----BA- Glucose-6-phosphate isomerase (GPI)----B-- YhjQ proteinEM----- Repeat of unknown function (DUF1126)EM----- Neural chondroitin sulphate proteoglycan cytoplasmic domain----B-- Domain of unknown function (DUF1127)----B-- Protein of unknown function (DUF1128)

Protein of unknown function (DUF1129)EM----- Churchill protein----B-- FAD synthetase


----B-- YOP proteins translocation protein K (YscK)Caenorhabditis elegans ly-6-related protein

----B-- Histidine kinaseEM----- Protein of unknown function (DUF1135)EM----- Repeat of unknown function (DUF1136)EM----- Neogenin C-terminusEM----- DIRPEM----- Haemolymph juvenile hormone binding protein (JHBP)----B-- TraK proteinEMF---- Muskelin N-terminus------V T4-like phage nuclear disruption protein (Ndd)----B-- Haemolysin-type calcium binding protein related domain------V Borna disease virus P24 proteinE---B-- Photosystem II reaction centre X protein (PsbX)

Chlorovirus glycoprotein repeat------V Protein of unknown function (DUF1139)

Protein of unknown function (DUF1140)------V Orthopoxvirus F6 proteinEMF---- Myotubularin-related

Protein of unknown function (DUF1141)EM----- ProkineticinEM----- Protein of unknown function (DUF1143)E-F---- Fungal trichothecene efflux pump (TRI12)----B-- Protein of unknown function (DUF1144)----B-- Protein of unknown function (DUF1145)


Sheet1

EM----- Neuromodulin------V Protein of unknown function (DUF1147)


EM----- Single-minded protein C-terminusSepQ protein

EMF---- Ribosome associated membrane protein RAMP4EM----- Protein of unknown function (DUF1151)EMFPBA- Catalase-related immune-responsive----B-- MltA-interacting protein MipAEM----- Protein of unknown function (DUF1154)EM-P--- DNA double-strand break repair and V(D)J recombination protein XRCC4----B-- Nodulation protein NolV

Protein of unknown function (DUF1157)EM----- PV-1 protein (PLVAP)EM----- Strabismus protein

Basal layer antifungal peptide (BAP)E--P--- P protein C-terminus----B-- Protein of unknown function (DUF1158)EMF---- ATP11 proteinEMFP--- Microsomal signal peptidase 12 kDa subunit (SPC12)----B-- High affinity transport system protein p37------V Protein of unknown function (DUF1160)----B-- Protein of unknown function (DUF1161)EMF---- Protein of unknown function (DUF1162)

Protein of unknown function (DUF1163)EM----- Methuselah N-terminus

Protein of unknown function (DUF1164)Tenuivirus PVC2 protein

EM----- Protein of unknown function (DUF1167)EM----- Protein of unknown function (DUF1168)EM---A- D-glucuronyl C5-epimerase C-terminusEM----- Protein of unknown function (DUF1170)EM----- Wnt-binding factor required for Wnt secretion----B-- Phage shock protein BEM----- Inter-alpha-trypsin inhibitor heavy chain C-terminus

Xylella fastidiosa surface protein relatedMicroneme protein Etmic-2

----B-- Protein of unknown function (DUF1175)Lactococcus lactis bacteriophage major capsid protein

----B-- Protein of unknown function (DUF1176)Protein of unknown function (DUF1178)

EMF--A- Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27)Protein of unknown function (DUF1179)

EM----- Protein of unknown function (DUF1180)EM----- Protein of unknown function (DUF1182)EM----- Protein of unknown function (DUF1183)

Protein of unknown function (DUF1184)----B-- Stage III sporulation protein AC/AD protein familyE-F---- SUR7/PalI family----B-- Protein of unknown function (DUF1187)----B-- ClpX C4-type zinc finger-----A- Protein of unknown function (DUF1188)----B-- Protein of unknown function (DUF1189)

Melon necrotic spot virus P7B proteinPlant nuclear matrix protein 1 (NMP1)Putative small multi-drug export protein

Sheet1

----B-- Streptococcal surface antigen repeatProtein of unknown function (DUF1191)Protein of unknown function (DUF1192)

EMF---- GPI biosynthesis protein family Pig-FEM----- Mib_herc2EM----- Protein of unknown function (DUF1193)EMFP--- Microsomal signal peptidase 25 kDa subunit (SPC25)

DspF/AvrF proteinE--P--- SF-assemblin/beta giardin

Citrus tristeza virus 6-kDa proteinProtein of unknown function (DUF1194)Protein of unknown function (DUF1195)

------V Protein of unknown function (DUF1199)----B-- Protein of unknown function (DUF1200)------V Gp5 C-terminal repeat (3 copies)------V Protein of unknown function (DUF1201)----B-- Protein of unknown function (DUF1202)------V Bacteriophage phi-29 early protein GP16.7----B-- MreB/Mbl protein----B-- Domain of Unknown Function (DUF1206)----B-- 3D domainEMF---V Bladder cancer-related protein BC10

Protein of unknown function (DUF1207)EMF---- GPI transamidase subunit PIG-UEM----- Protein of unknown function (DUF1208)EMFP--- Pescadillo N-terminusEMFPBA- DEAD_2------V UL97EM----- Protein of unknown function (DUF1211)----B-- Transglycosylase-like domainE-F-B-- Protein of unknown function (DUF1212)

Beta-propeller repeatEM----- Protein of unknown function (DUF1213)EMF---- LsmAD domain

Protein of unknown function (DUF1214)EM----- FAST kinase-like protein, subdomain 1

Protein of unknown function (DUF1215)EMF-BAV KaiC

Protein of unknown function (DUF1216)EMF---- CHCH domain


----B-- Bacterial Peptidase A24 N-terminal domain----B-- Ethanolamine ammonia lyase large subunit (EutB)EM----- Enhancer of Polycomb C-terminusEM----- Chorion protein S19 C-terminalEM----- Insect allergen related repeat, nitrile-specifier detoxificationEM----- Repeat of unknown function (DUF1220)

Protein of unknown function (DUF1221)Intracellular multiplication and human macrophage-killing

EM----- Protein of unknown function (DUF1222)Protein of unknown function (DUF1223)

E-F---- Fungal hydrophobin----B-- Sif protein----B-- Plasmid encoded toxin TxeE-----V Actin-rearrangement-inducing factor (Arif-1)------V Viral Desmoplakin N-terminus

Sheet1

----B-- Bacterial low temperature requirement A protein (LtrA)EMF---- Putative adipose-regulatory protein (Seipin)----B-- Invasion associated locus B (IalB) proteinEMFP--- Protein of unknown function (DUF1227)----BA- Chlorite dismutase----B-- Protein of unknown function (DUF1228)

Erp protein C-terminus----B-- Uncharacterised protein family (UPF0233)----B-- Uncharacterised protein family (UPF0236)EM----- Uncharacterised protein family (UPF0239)EM----- Uncharacterised protein family (UPF0240)----B-- Uncharacterised protein family (UPF0242)----B-- Uncharacterised protein family (UPF0253)-----A- Uncharacterised protein family (UPF0254)----B-- Uncharacterised protein family (UPF0257)EM----- Uncharacterised protein family (UPF0258)----B-- Uncharacterised protein family (UPF0259)----B-V Prophage tail length tape measure protein----B-- Uncharacterised protein family (UPF0270)

Erythrovirus X protein----B-- Periplasmic nitrate reductase protein NapE

Protein of unknown function (DUF1229)----B-- PrkA serine protein kinase C-terminal domainE------ Protein of unknown function (DUF1230)------V Protein of unknown function (DUF1231)EM----- Protein of unknown function (DUF1232)----B-- NlpB/DapX lipoprotein------V Bacteriophage lambda tail assembly protein IEMF--A- Pre-mRNA cleavage complex II protein Clp1----B-- DctM-like transportersEM----- Neural proliferation differentiation control-1 protein (NPDC1)------V Phage minor structural protein GP20

ImpA-related N-terminalEMF---- Lung seven transmembrane receptor------V Reverse transcriptase connection domainEM----- NOTCH proteinEM----V Reverse transcriptase thumb domainEM----- Fez1-----A- Archaeal Peptidase A24 C-terminal Domain

Putative prophage tail fibre C-terminusEM--B-- Alpha/Beta hydrolase family of unknown function (DUF1234)

Protein of unknown function (DUF1236)EMF---- Heat shock factor binding protein 1EM--B-- Zinc finger found in FPG and IleRS----B-- Penicillin-Binding Protein C-terminus Family

Malonate decarboxylase gamma subunit (MdcE)----B-- TraU protein

Protein of unknown function (DUF1240)Fijivirus P9-2 protein

----B-- Aluminium resistance protein EMF---- GRF zinc fingerEM----- Protein of unknown function (DUF1241)------V T4-like virus tail tube protein gp19EMF---- Protein of unknown function (DUF1242)

Protein of unknown function (DUF1244)-----A- Archaeal Peptidase A24 C-terminus Type II-----A- Protein of unknown function (DUF1246)

Sheet1

PHB de-polymerase C-terminusProtein of unknown function (DUF1248)Bacteriophage Gp15 protein

----B-- Protein of unknown function (DUF1250)------V Protein of unknown function (DUF1251)EMFP-A- Nucleolar GTP-binding protein 1 (NOG1)EMF---- Bicoid-interacting protein 3 (Bin3)------V BALF1 proteinEMF---- Protein of unknown function (DUF1253)

Protein of unknown function (DUF1254)Pilin accessory protein (PilO)

----B-- Protein of unknown function (DUF1256)EM----- Protein of unknown function (DUF1258)EMF---- A49-like RNA polymerase I associated factor ----B-- TraH_2EM----- Plethodontid receptivity factor PRFE--P--- Plant self-incompatibility response (SCRL) protein----B-- Protein of unknown function (DUF1260)------V Pkip-1 protein


EMF---- RNA polymerase II transcription factor SIII (Elongin) subunit AProtein of unknown function (DUF1263)

EMF---- RNA polymerase I, Rpa2 specific domain Protein of unknown function (DUF1264)

EM----- Targeting protein for Xklp2 (TPX2)Protein of unknown function (DUF1265)

EMF-B-- Putative Phosphatase----B-V Bacteriophage Mu Gp45 protein----B-V Phage regulatory protein CII (CP76)------V Bacteriophage lambda minor tail protein (GpG)


----B-- Putative stage IV sporulation protein YqfDProtein of unknown function (DUF1270)RTX iron-regulated protein FrpC

----BA- Protein of unknown function (DUF1271)EM----- Fas apoptotic inhibitory molecule (FAIM1)----B-- Protein of unknown function (DUF1272)----B-- Protein of unknown function (DUF1273)EM----- Male enhanced antigen 1 (MEA1)EM----- Senescence-associated protein----B-- Protein of unknown function (DUF1275)EMF---- Protein of unknown function (DUF1279)----B-- Periplasmic pectate lyase

Protein of unknown function (DUF1280)EMF---- Dedicator of cytokinesis

Citrus tristeza virus P13 protein----B-- Glucitol operon activator protein (GutM)----B-- Protein of unknown function (DUF1281)E--PB-- Monogalactosyldiacylglycerol (MGDG) synthase

Putative replisome organiser protein C-terminus------V Rotavirus VP3 protein----B-- Protein of unknown function (DUF1282)------V Mastadenovirus E4 ORF3 protein----B-- Protein of unknown function (DUF1283)

Special lobe-specific silk protein SSP160

Sheet1

Protein of unknown function (DUF1284)EM----- Selenoprotein S (SelS)EM----- EURL protein


EM--B-V 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)----B-- GlpM proteinE--P--- LSD1 zinc finger----B-- Protein of unknown function (DUF1289)------V Phage holin----B-- Protein of unknown function (DUF1290)----B-- Protein of unknown function (DUF1292)EM----- Group XII secretory phospholipase A2 precursor (PLA2G12)EM----- ResistinE--P--- Xyloglucan endo-transglycosylase (XET) C-terminus----B-- Regulator of RNA terminal phosphate cyclaseEMFP--- Coatomer (COPI) alpha subunit C-terminusEM----- RecQ helicase protein-like 5 (RecQ5)----B-- Protein of unknown function (DUF1294)

Putative rRNA methylaseEM----- Ferroportin1 (FPN1)E-F-B-- Alpha-L-arabinofuranosidase C-terminusE-F---- Protein of unknown function (DUF1295)

Mo-dependent nitrogenase C-terminusE-FPBA- Biotin and Thiamin Synthesis associated domainEM--B-- HemN C-terminal region----B-- Replication initiator protein A (RepA) N-terminus----B-- Putative DNA-binding protein N-terminus

Protein of unknown function (DUF1296)-----A- Domain of unknown function (DUF1297)E--PB-- Protein of unknown function (DUF1298)----B-- SdiA-regulatedEMF---- Ribonucleases P/MRP protein subunit POP1EM----- Protein of unknown function (DUF1301)

Protein of unknown function (DUF1302)EMF---- Mitochondrial 39-S ribosomal protein L47 (MRP-L47)E-F---- Heterokaryon incompatibility protein (HET)----B-- Mating pair stabilisation protein TraN----B-- NifT/FixU proteinEM----- Galactose-3-O-sulfotransferase EMF---- Micro-fibrillar-associated protein 1 C-terminus----B-V Replication protein P

Phage P2 GpUProtein of unknown function (DUF1305)

E-F---- Sucrase/ferredoxin-likeEM----V Protein of unknown function (DUF1308)EM----- BAT2 N-terminusEM----- Protein of unknown function (DUF1309)

Protein of unknown function (DUF1310)----B-- Protein of unknown function (DUF1311)----B-- Protein of unknown function (DUF1312)EM----- Endomucin

Protein of unknown function (DUF1313)----B-- Curlin associated repeat------V Protein of unknown function (DUF1314)----B-- VirC1 proteinE------ Cysteine-rich acidic integral membrane protein precursor

Sheet1

EMF---- Rab5-interacting protein (Rab5ip)Methionine biosynthesis protein MetW

----B-V Bacteriophage CI repressor helix-turn-helix domain----B-- Protein of unknown function (DUF1315)

ImpE protein----B-- Protein of unknown function (DUF1318)------V Protein of unknown function (DUF1319)----B-- CryBP1 protein----B-V Protein of unknown function (DUF1320)

Protein of unknown function (DUF1322)------V Orthopoxvirus B11R proteinEMF---- Origin recognition complex (ORC) subunit 3 N-terminusEM----- Colon cancer-associated protein Mic1-like----B-- Putative transcription regulator (DUF1323)

Protein of unknown function (DUF1324)EMF---- SGF29 tudor-like domain----B-- Protein of unknown function (DUF1327)----B-- TrfA protein----B-- Protein of unknown function (DUF1329)

Protein of unknown function (DUF1330)Cytoplasmic repetitive antigen (CRA) like repeat

EMF---- Optic atrophy 3 protein (OPA3)Protein of unknown function (DUF1331)

EM----- Ovarian carcinoma immunoreactive antigen (OCIA)EM----- Hepatocellular carcinoma-associated antigen 59EM----- Pericardin like repeatE---B-- Enoyl reductase FAD binding domain----B-- DNA helicase TraI

Myosin II heavy chain-likeEMF---- Swi5EM----- Clc-like----B-- Protein of unknown function (DUF1338)EMF---- RIC1EMF---V D123

Protein of unknown function (DUF1340)------V Porcine reproductive and respiratory syndrome virus 2b ----B-- SpoOM protein----B-- Protein of unknown function (DUF1342)----B-- Modulator of Rho-dependent transcription termination (ROF)EM----- Translocon-associated protein, gamma subunit (TRAP-gamma)----B-- Protein of unknown function (DUF1343)


EM----- Forty-two-three proteinProtein of unknown function (DUF1347)Protein of unknown function (DUF1350)Protein of unknown function (DUF1351)

EM----- Thyroid hormone-inducible hepatic protein Spot 14EM----- Protein of unknown function (DUF1352)----B-- Protein of unknown function (DUF1353)-----A- GvpD gas vesicle protein

Protein of unknown function (DUF1355)----B-- Ribosomal RNA methyltransferase (FmrO)EM----- Protein of unknown function (DUF1356)EMFP--- SGT1 protein----B-- Intracellular growth attenuator protein IgaAEM----- Protein of unknown function (DUF1358)

Sheet1


Protein of unknown function (DUF1361)Anabaena sensory rhodopsin transducer

----B-V Protein of unknown function (DUF1364)Protein of unknown function (DUF1365)Protein of unknown function (DUF1366)Protein of unknown function (DUF1367)

EMFP--- Tat binding protein 1(TBP-1)-interacting protein (TBPIP)E--P--- Wound-induced protein WI12

PipA protein----B-- Magnesium-protoporphyrin IX methyltransferase C-terminus----B-- EthD proteinEM----- Alpha helical coiled-coil rod protein (HCR)

Protein of unknown function (DUF1368)EM----- Protein of unknown function (DUF1370)

Protein of unknown function (DUF1371)------V Protein of unknown function (DUF1374)----B-- Protein of unknown function (DUF1375)----B-- Protein of unknown function (DUF1376)

Variable length PCR target protein (VLPT)E--P--- Photosystem II reaction centre W protein (PsbW)------V Phytoreovirus outer capsid protein P8

Protein of unknown function (DUF1378)E--P--- Late nodulin protein----B-- Protein of unknown function (DUF1380)

Protein of unknown function (DUF1381)----B-- YebG protein

Merozoite surface protein (SPAM)------V Protein of unknown function (DUF1383)----B-- Protein of unknown function (DUF1385)E--P--- Violaxanthin de-epoxidase (VDE)EM----- Protein of unknown function (DUF1387)

Putative bacteriophage terminase small subunit----B-- Hydroxyneurosporene synthase (CrtC)EM----- Ataxin-2 C-terminal region

Protein of unknown function (DUF1389)EM----- Mitochondrial 28S ribosomal protein S30 (PDCD9)EM----- Pes-10

Protein of unknown function (DUF1390)----B-- Protein of unknown function (DUF1391)------V Marek's disease-like virus SORF3 protein

Protein of unknown function (DUF1392)----BA- Protein of unknown function (DUF1393)EM-P--- Prenylcysteine lyase

Dicarboxylate carrier protein MatC N-terminusEM----- Protein of unknown function (DUF1394)EM-P--- Protein of unknown function (DUF1395)EM----- B9 proteinEM----- Pex26 proteinEM----- Protein of unknown function (DUF1397)----B-- Protein of unknown function (DUF1398)E--P--- Fatty acid elongase 3-ketoacyl-CoA synthase 1E--P--- Glycine rich protein family

Protein of unknown function (DUF1399)----B-- Fibronectin-attachment protein (FAP)EM----- Osteoregulin

Sheet1

Alpha/beta hydrolase of unknown function (DUF1400)EM----- Neuralized----B-- TraL protein----B-- Protein of unknown function (DUF1401)----B-- VirC2 protein

Protein of unknown function (DUF1402)Protein of unknown function (DUF1403)Citrus tristeza virus P33 proteinKaposi's sarcoma-associated herpesvirus (KSHV) K8 protein

EMFP--- Splicing factor 3B subunit 10 (SF3b10)------V Protein of unknown function (DUF1406)----B-- Protein of unknown function (DUF1407)EM----- SNURF/RPN4 protein

Protein of unknown function (DUF1408)----B-- P2 response regulator binding domain----B-- Flagellar hook-associated protein 2 C-terminus

Protein of unknown function (DUF1409)DUF1410 domainProtein of unknown function (DUF1411)

EMFP--- Modifier of rudimentary (Mod(r)) protein----B-- HrpJ-like domainEM----- T-complex protein 10 C-terminus

Protein of unknown function (DUF1412)Orthoreovirus membrane fusion protein p10Protein of unknown function (DUF1413)

------V Baculovirus late expression factor 10 (LEF-10)E--P--- Light regulated protein Lir1----B-- Protein of unknown function (DUF1414)


EM----- DAP10 membrane protein----B-- Protein of unknown function (DUF1418)----B-- LcrG protein

Heterokaryon incompatibility protein Het-CRhoptry-associated protein 1 (RAP-1)

----B-- HemY protein N-terminusEM--B-- N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)EM----- Proacrosin binding protein sp32

Protein of unknown function (DUF1421)E--P--- ChlorophyllaseEM----- NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4)----B-- Protein of unknown function (DUF1422)E--P--- Protein of unknown function (DUF1423)EMFPB-- Stage II sporulation protein E (SpoIIE)----B-- VirE2

Hs1pro-1 N-terminus-----A- Putative rep protein (DUF1424)------V Protein of unknown function (DUF1426)

Protein of unknown function (DUF1427)----B-- Protein of unknown function (DUF1428)EM----- Stress-inducible humoral factor Turandot

Protein of unknown function (DUF1430)------V Phlebovirus glycoprotein G1E--PB-- Surface antigen variable number repeat------V Phlebovirus glycoprotein G2------V Phlebovirus nonstructural protein NS-ME-F---- Alcohol acetyltransferase

Sheet1

Protein of unknown function (DUF1431)E-F---- Cerato-platanin

Glyoxal oxidase N-terminusEM----- Gypsy protein----B-- Protein of unknown function (DUF1434)

Benyvirus 14KDa protein----B-- Protein of unknown function (DUF1435)EM----- HCaRG proteinEM----- ProSAAS precursor----B-- Replication initiation and membrane attachment protein (DnaB)EM----- Dentin matrix protein 1 (DMP1)EM----V Etoposide-induced protein 2.4 (EI24)

Tapetum specific protein TAP35/TAP44------V Nucleopolyhedrovirus capsid protein P87

Exported protein precursor (EppA/BapA)----B-- Cytadhesin P30/P32----B-- Protein of unknown function (DUF1439)----B-- Protein of unknown function (DUF1440)

Antirestriction protein (ArdA)SapC

------V Protein of unknown function (DUF1443)EMF---- Insulin-induced protein (INSIG)----BAV Putative transposase DNA-binding domain----B-- Conjugal transfer protein TrbH----B-- Protein of unknown function (DUF1444)EMF-B-- Protein of unknown function (DUF1445)

Protein of unknown function (DUF1446)----B-- Protein of unknown function (DUF1447)EM----- Protein of unknown function (DUF1448)----B-- Protein of unknown function (DUF1449)----B-- Methylamine utilisation protein MauEEM----- Nmi/IFP 35 domain (NID)----B-- Protein of unknown function (DUF1450)----B-- Protein of unknown function (DUF1451)----B-- TraP proteinEMF---- Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)EM----- NnrU protein

Fibronectin-binding protein (FBP)----B-- Protein of unknown function (DUF1453)----B-- AroM proteinEM----- Occludin homology domainEMF---- Steroid receptor RNA activator (SRA1)----B-- Protein of unknown function (DUF1454)----B-- Protein of unknown function (DUF1456)----B-- Flagellar protein FlaF

PAS domainProtein of unknown function (DUF1458)Protein of unknown function (DUF1460)

----B-- Protein of unknown function (DUF1461)Protein of unknown function (DUF1462)Protein of unknown function (DUF1463)

----B-- YcgR protein----B-- Primosomal protein DnaI N-terminusEM--B-- Type III secretion protein YscO

Protein of unknown function (DUF1465)EM----- DiGeorge syndrome critical region 6 (DGCR6) protein------V Curtovirus V2 protein

Sheet1

EM----- Protein of unknown function (DUF1466)EM----- Neuroparsin----B-- T-DNA border endonuclease VirD1

Protein of unknown function (DUF1467)----B-- Tripartite tricarboxylate transporter TctB family----B-- Protein of unknown function (DUF1469)EM-P--- S locus-related glycoprotein 1 binding pollen coat protein (SLR1-BP)EM-P--- Interferon-induced 35 kDa protein (IFP 35) N-terminus


Protein of unknown function (DUF1474)Protein of unknown function (DUF1475)Amastin surface glycoproteinDomain of unknown function (DUF1476)

------V Protein of unknown function (DUF1477)EM----- NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)------V Protein of unknown function (DUF1478)----B-- Protein of unknown function (DUF1480)----B-V Bacteriophage Mu Gam like proteinEM----- Uroplakin IIEM----- Zona-pellucida-binding protein (Sp38)----B-- Glycine/sarcosine/betaine reductase selenoprotein B (GRDB)----B-- Dinitrogenase reductase ADP-ribosyltransferase (DRAT)----B-- Protein of unknown function (DUF1482)EM----- Liver-expressed antimicrobial peptide 2 precursor (LEAP-2)----B-- Cytochrome b562----B-- Post-segregation antitoxin CcdA

Protein of unknown function (DUF1484)EM----- Alpha conotoxin precursorE-F---- Fungal fruit body lectin

Protein of unknown function (DUF1487)----B-- Protein of unknown function (DUF1488)----B-- Protein of unknown function (DUF1490)----B-- CAMP factor (Cfa)

Protein of unknown function (DUF1492)Tenuivirus PV2 proteinProtein of unknown function (DUF1493)

----B-- Flagellar protein FlbT------V Pneumovirus M2 protein-----A- Winged helix DNA-binding domain (DUF1495)----B-- Histone H1-like nucleoprotein HC2----B-- Protein of unknown function (DUF1496)

Protein of unknown function (DUF1499)Seadornavirus VP7

------V Protein of unknown function (DUF1500)Mycoplasma P30 protein

EMFP--- Exocyst complex component Sec10Protein of unknown function (DUF1501)Mig-14Repeat of unknown function (DUF1502)MDMPI C-terminal domain

EM----- Interleukin 11------V Bovine Lentivirus VIF proteinE------ Telomere-binding protein beta subunit (TEBP beta)

Protein of unknown function (DUF1506)EM----- NICE-3 protein

Seadornavirus VP6 protein

Sheet1

----B-- Protein of unknown function (DUF1507)----B-V Phage protein GP46----BA- Domain of unknown function (DUF1508)EM----- Geminin------V Betaherpesvirus immediate-early glycoprotein UL37------V Gammaherpesvirus latent membrane protein (LMP2) protein

Crinivirus P26 protein----B-- Transcriptional regulator CrlE------ Acidic phosphoprotein precursor PCEMA1

Protein of unknown function (DUF1509)E------ Sexual stage antigen s48/45 domain

Protein of unknown function (DUF1510)TrbM

EM----- Dynactin subunit p2215-O-acetyltransferase Tri3Phloem filament protein PP1Protein of unknown function (DUF1512)

----B-- Histone H1-like protein Hc1Protein of unknown function (DUF1513)

----B-- CblD like pilus biogenesis initiator----B-- YycH protein------V Curtovirus V3 protein


EM----- Caerin 1 protein----B-- SigmaK-factor processing regulatory protein BofAEM----- PonericinEM----- HepA-related protein (HARP)E--PB-- Ycf66 protein N-terminus----B-- Primosomal replication protein priB and priCEM--B-- GumN protein------V Matrix protein VP40EM----- Secreted phosphoprotein 24 (Spp-24)----B-- Hydrogenase-1 expression protein HyaE----B-- Formate hydrogenlyase maturation protein HycH----B-- Stage V sporulation protein AD (SpoVAD)EM----- CHRD domainE-F---V NUMOD1 domain----B-- Stage II sporulation protein P (SpoIIP)------V Phage polarity suppression protein (Psu)

Heptaprenyl diphosphate synthase component I----B-- Protein of unknown function (DUF1516)EM----- Sperm protein associated with nucleus, mapped to X chromosome

CTX phage RstB proteinE-F---V NUMOD3 motifEM----- Merozoite surface protein 1 (MSP1) C-terminusEM----- Apolipophorin-III precursor (apoLp-III)E--PB-- Photosystem I protein M (PsaM)

Protein of unknown function (DUF1517)----B-- Beta-lactamase inhibitor (BLIP)

AgglutininEM----- Domain of unknown function (DUF1518) ----B-- Glycosyl Hydrolase Family 88----B-V Phage DNA packaging protein Nu1

Fucose-binding lectin II (PA-IIL)EM----- Spasmodic peptide gm9aEM----- G2F domain

Sheet1

----B-- HPr Serine kinase C-terminal domain----B-- Methylaspartate ammonia-lyase C-terminusE-F-B-- Glycosyl hydrolase family 67 C-terminus----B-- D-ala D-ala ligase C-terminusEMFPBA- NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus

Domain of Unknown Function (DUF1520)Domain of Unknown Function (DUF1521)Domain of Unknown Function (DUF1522)Domain of Unknown Function (DUF1259)

E-F-B-- Glycosyl hydrolase family 67 middle domainTranslocated intimin receptor (Tir) C-terminusTranslocated intimin receptor (Tir) N-terminus

EMF---- Protein phosphatase inhibitor E-F---- Neutral trehalase Ca2+ binding domain

Two component regulator propellerY_Y_Y domain

EM-P--- CW-type Zinc Finger----B-- Rho termination factor, RNA-binding domainE--PB-V Rho termination factor, N-terminal domain----B-- RuvA, C-terminal domainEMF---- Transcription factor S-II (TFIIS), central domain----B-- G5 domainEM----- MANEC domain----BA- HypF fingerE-F-B-- Fungalysin/Thermolysin Propeptide Motif

Phage protein Gp37/Gp68----B-- RepB plasmid partitioning protein

WavE lipopolysaccharide synthesis----B-V Recombinase----B-- Protein of unknown function (DUF1524)


E--PB-- SecA Wing and Scaffold domainE--PB-- SecA DEAD-like domain

Virulence factor SrfBEMFPBA- RNA-metabolising metallo-beta-lactamaseEMFP--- DNA repair metallo-beta-lactamase----B-- Bacterial Ig-like domain (group 3)EMF---- Bromodomain associatedEM----- SOCS boxE--P--- Associated with HOXEM----- Hairy OrangeEM----- DZFEMF---- HSAEM----- Associated with zinc fingersEM----- NHR1 homology to TAF

Bacterial Ig-like domain (group 4)EM----- BRK domainEMF---- TLDEMF---- DBF zinc finger----B-- HWE histidine kinaseEMF---- Down-regulated in metastasisEMF---- Nucleolar complex-associated proteinEMF--A- Eukaryotic translation initiation factor 2 alpha subunitEMF---- ATP12 chaperone proteinE-F---- Protein trafficking PGA2

Sheet1

EMF---- RNA polymerase II transcription mediator complex subunit 9EM----- Vestigial/Tondu familyEM----- EMI domain----B-- Chlamydia polymorphic membrane protein middle domain----BA- SecD/SecF GG Motif


----B-- Spore Coat Protein X and V domainHost cell surface-exposed lipoprotein

----B-- Uncharacterised Sugar-binding DomainEM--B-- beta-N-acetylglucosaminidase EMFP--- Shugoshin C terminusEMFP--- Shugoshin N-terminal coiled-coil region----B-- Flagellar basal body protein FlaE

Domain of Unknown Function (DUF1539)Domain of Unknown Function (DUF1540)

EM----- Nine Cysteines Domain of family 3 GPCR----B-- Domain of Unknown Function (DUF1542)EM----- Band 3 cytoplasmic domain

Domain of Unknown Function (DUF1543)----B-- Histidine kinaseEMFP--- TUP1-like enhancer of splitEMF---- Protein of unknown function (DUF1546)EMF---- Bucentaur or craniofacial developmentEMF---- Nse1 non-SMC component of SMC5-6 complexEMF---- Nup85 NucleoporinEMF---- BRCA1-associated protein 2----B-- Domain of Unknown Function (DUF1547)----B-- Lipid A Biosynthesis N-terminal domain

Domain of Unknown Function (DUF1548)----BA- The GLUG motif----B-- AP endonuclease family 2 C terminus

Protein of unknown function (DUF1549)Aerotolerance regulator N-terminalProtein of unknown function (DUF1551)Protein of unknown function (DUF1552)Protein of unknown function (DUF1553)Protein of unknown function (DUF1556)

-----A- Protein of unknown function (DUF1557)Rhodopirellula transposase

EM----- ASPIC and UnbVPlanctomycete extracellularProtein of unknown function (DUF1559)Protein of unknown function (DUF1560)Protein of unknown function (DUF1564)Protein of unknown function (DUF1562)

EM--B-- Protein of unknown function (DUF1565)Protein of unknown function (DUF1567)Protein of unknown function (DUF1570)Protein of unknown function (DUF1577)Protein of unknown function (DUF1579)Protein of unknown function (DUF1580)SLEIProtein of unknown function (DUF1582)Protein of unknown function (DUF1584)Protein of unknown function (DUF1585)Protein of unknown function (DUF1586)

Sheet1

Protein of unknown function (DUF1587)Protein of unknown function (DUF1588)Protein of unknown function (DUF1590)Protein of unknown function (DUF1592)Protein of unknown function (DUF1593)RtxA repeatPSRTProtein of unknown function (DUF1595)

----B-- ECF sigma factorYTVQPP

EM-P--- Calcium-binding EGF domainEMFPB-- Kelch motifEMF---- SAM domain (Sterile alpha motif)EM----- Kazal-type serine protease inhibitor domain

C1-like domainEMFPBA- KH domainEMFP--- ANTH domain------V Flavivirus DEAD domain EMF---- Variant SH3 domainEM----V Immunoglobulin C1-set domain----B-- Secretin N-terminal domain

KWG LeptospiraEM----- N terminus of Notch ligand

Domain of Unknown Function (DUF1599)----B-V Secretin and TonB N terminus short domain----B-- MORN repeat variantEM--B-- Na+ dependent nucleoside transporter C-terminus----BA- Ferrous iron transport protein B C terminus

M penetrans paralogue family 26----B-- Protein of unknown function (DUF1600)----B-- M penetrans paralogue family 1----BA- Eco57I restriction endonucleaseEM--BA- Nucleoside recognition

Protein of unknown function (DUF1601)----B-- Mycoplasma MFS transporter

Protein of unknown function (DUF1602)----B-- Cleaved Adhesin DomainEMF-BA- WD40-like Beta Propeller RepeatEM----- A-macroglobulin receptorEM----- A-macroglobulin complement componentEM--B-V Immunoglobulin I-set domain

TQO small subunit DoxA----B-- DoxXEMF-B-- Cobalamin synthesis protein cobW C-terminal domainEM----- NOTCH protein----BA- CobB/CobQ-like glutamine amidotransferase domainEM----V Immunoglobulin V-set domainEMFPBA- Peptidase dimerisation domain----B-- KaiA domain----B-- KaiB domainEMFPBA- Major Facilitator SuperfamilyEM--BA- KAP family P-loop domain

7TM diverse intracellular signalling7TMR-DISM extracellular 2

----B-- 7TM-HD extracellularEM----- GCC2 and GCC3

Sheet1

EM----- Heme NO bindingEM----- Heme NO binding associated----B-- UTRA domainEM--B-- Alpha-2-macroglobulin family N-terminal region----B-- Rv0623-like transcription factor----BA- CARDBEM----- Aminotransferase ubiquitination siteEM-P--V BTB And C-terminal KelchEM----- P53 tetramerisation motifEM----- Rab geranylgeranyl transferase alpha-subunit, insert domain EMF---- Protein of unknown function (DUF1604)EM-P--V Protein tyrosine kinase----B-- TonB-dependent Receptor Plug DomainEMFP--- Basic region leucine zipperEMFPB-- Domain of unknown function (DUF1605)EMFP--- Coatamer beta C-terminal regionEMFPB-- Tetratricopeptide repeat----BA- Tetratricopeptide repeatEM--B-- Tetratricopeptide repeatEMFPB-- Peptidase C26EM-P--- Leucine Rich RepeatEMFPB-- AAA domain (Cdc48 subfamily)E--P--- Leucine Rich Repeat----B-- ATPase family associated with various cellular activities (AAA)EMFP--- Reverse transcriptase (RNA-dependent DNA polymerase)EMFPBAV AAA domain (dynein-related subfamily)----B-- FCD domain----B-- Histidine kinaseEMFPB-- Multicopper oxidaseEMFPB-- Multicopper oxidase----B-- Bacterial DNA polymerase III alpha subunitE--P--- F-box associatedEM----- F-box associatedEMF---- Sad1 / UNC-like C-terminal ----B-- TipAS antibiotic-recognition domainEM----- Spider potassium channel inhibitory toxinEMF---- Brf1-like TBP-binding domainEM----- BTG familyEMF-B-- HSCB C-terminal oligomerisation domainEMF---- SPOC domainE-F-B-- Glycosyl hydrolase family 53----B-- Aromatic-ring-opening dioxygenase LigAB, LigA subunit-----A- MTH865-like familyEMF-B-- Glycosyl hydrolases family 38 C-terminal domainEMFP--- Endoplasmic reticulum protein ERp29, C-terminal domain

GcrA cell cycle regulatorAbi-like protein

-----A- Domain of unknown function (DUF1610)Protein of unknown function (DUF1611)

EMF---- Predicted AdoMet-dependent methyltransferaseProtein of unknown function (DUF1616)Protein of unknown function (DUF1618)

EM----- FEZ-like proteinKIP1-like protein

EMF---- LETM1-like proteinEMFP--- Nop53 (60S ribosomal biogenesis)

PVL ORF-50-like family

Sheet1

----B-- psiF repeatTick salivary peptide group 1

EM----- Protein of unknown function (DUF1619)EMF---- Protein of unknown function (DUF1620)

PaRep2b proteinEM----- Zinc-finger associated domain (zf-AD) E--P--- G-box binding protein MFMREMF---- Mis6 EMF---- Cas1p-like proteinEMF---- Spb1 C-terminal domain------V Reovirus minor core protein Mu-2EM----- DC-STAMP-like protein

Protein of unknown function (DUF1622)EM----- Protein of unknown function (DUF1624)EM----- Protein of unknown function (DUF1625)

Protein of unknown function (DUF1626)----B-- Protein of unknown function (DUF1627)-----A- Protein of unknown function (DUF1628)EM----- Protein of unknown function (DUF1630)


EMF---- Protein of unknown function (DUF1640)Protein of unknown function (DUF1643)Protein of unknown function (DUF1644)Protein of unknown function (DUF1647)GCK domain

EM----- GSG1-like protein----B-- HipA-like C-terminal domain----B-- HipA-like N-terminal domainEM----- RED-like protein C-terminal regionEMF---- RED-like protein N-terminal regionEM----- RTP801 C-terminal regionEM----- TMC domain

TadE-like proteinTfuA-like protein

----B-- LTXXQ motifEMF---- Wings apart-like protein regulation of heterochromatinEM----- Abl-interactor HHR

Protein of unknown function (DUF1645)EMF---- GLE1-like proteinEMF---- HCNGP-like proteinEMF---- PGAP1-like protein----B-- TraC-like proteinE--P--- Alpha-amylase C-terminal beta-sheet domainEM----- Neurotoxin B-IV-like proteinE-FP--- Cyclic phosphodiesterase-like protein----B-- Type III secretion chaperone domain----B-- KNTase C-terminal domainEM----- Protein serine/threonine phosphatase 2C, C-terminal domainEM--BA- Pyrimidine nucleoside phosphorylase C-terminal domain----B-- Copper amine oxidase N-terminal domainEM----- RanGAP1 C-terminal domainEM----- Formiminotransferase domain, N-terminal subdomain

Plant calmodulin-binding domain----B-- FadR C-terminal domain

DM4/DM12 family

Sheet1

EMF---- GC-rich sequence DNA-binding factor-like proteinProtein of unknown function (DUF1634)Protein of unknown function (DUF1636)

E------ Metallothionein family 7EM----- Protein of unknown function (DUF1637)----B-- PaaX-like protein----BA- Protein of unknown function (DUF1641)EM----- Renin receptor-like proteinEM----- TMPIT-like protein

Protein of unknown function (DUF1642)----BA- Protein of unknown function (DUF1648)EMF---- Protein of unknown function (DUF1649)EM----- Mediator of CRAC channel activityEM----- CEO family (DUF1632)----B-- Limonene-1,2-epoxide hydrolase catalytic domainEMFPB-V alpha/beta hydrolase fold

WisP family C-Terminal RegionNitrogen fixation protein of unknown functionProtein of unknown function (DUF1651)Protein of unknown function (DUF1653)Protein of unknown function (DUF1654)

----B-- Protein of unknown function (DUF1656)Protein of unknown function (DUF1657)Protein of unknown function (DUF1658)Protein of unknown function (DUF1659)

----B-- YabP familyProphage protein (DUF1660)

----B-- Coat F domainProtein of unknown function (DUF1661)Protein of unknown function (DUF1662)

----B-- PHB/PHA accumulation regulator DNA-binding domain----B-- L-fucose isomerase, first N-terminal domain----B-- L-fucose isomerase, second N-terminal domainE-FPBAV Cupin domainEM----- Vitamin K epoxide reductase familyEMFPBA- Ion channel

Calmodulin binding protein-likeEM----- Calcium binding and coiled-coil domain (CALCOCO1) like

Protein of unknown function (DUF1664)EMF---- Rrp15p


EM----- Protein of unknown function (DUF1669)Protein of unknown function (DUF1673)

EMF-B-- Protein of unknown function (DUF1674)E--P--- Protein of unknown function (DUF1675)

Protein of unknown function (DUF1676)E--P--- Frigida-like protein

Protein of unknown function (DUF1670)Protein of unknown function (DUF1672)gp58-like protein

EMF---- CT20 family----B-- Purine catabolism regulatory protein-like family----B-- ShET2 enterotoxin, N-terminal region

YibE/F-like protein----B-- D-aminoacylase, C-terminal region

Sheet1

EMFP--- Peptidase family C78Protein of unknown function (DUF1677)

EM----- ERp29, N-terminal domainProtein of unknown function (DUF1678)

EM----- Protein of unknown function (DUF1679)EMF---- Glucosidase II beta subunit-like protein----B-- TraG-like protein, N-terminal regionEM----- Protein of unknown function (DUF1683)------V Fibritin C-terminal region----B-- Glycosyltransferase family 52EMF---- N1221-like protein

Nuclease A inhibitor-like proteinEMF---- TPR/MLP1/MLP2-like protein----B-- YcfA-like proteinEMF---- Vps54-like protein----B-- D-aminopeptidase, domain B----B-- Chloramphenicol phosphotransferase-like proteinEM-P--- Protein of unknown function (DUF1681)EMF-BA- 8-oxoguanine DNA glycosylase, N-terminal domain------V ORF D-335-like proteinE-F---- Fungal fucose-specific lectin

Protein of unknown function (DUF1685)Heparinase II/III-like protein

EM----- Potassium channel Kv1.4 tandem inactivation domainEMF---- N2227-like protein----B-- Penicillin-binding protein 5, C-terminal domain

Putative glycosyl hydrolase of unknown function (DUF1680)EM----- Janus-atracotoxinEMFP--- Protein of unknown function (DUF1682)EM--B-- YhhN-like protein------V Nairovirus M polyprotein-like----B-- YbbR-like proteinE-F---- Protein of unknown function (DUF1691)----B-- Clostridium neurotoxin, C-terminal receptor binding----B-- Clostridium neurotoxin, Translocation domainE-F---- Protein of unknown function (DUF1689) E-F---- Protein of Unknown function (DUF1690) E-F---- Protein of unknown function (DUF3294)E-F---- Protein of unknown function (DUF1688)EM----- L-fucokinaseE-F---- CBP4E-F---- MBA1-like proteinEMF---- Replication Fork Protection Component Swi3E-F---- Rec10 / Red1EM----- Integrin beta tail domainEM----- A1 Propeptide EMF---- C3HC zinc finger-like EM--BA- Amidohydrolase familyEMF---- Endoplasmic reticulum vesicle transporter

Glycosyl hydrolase family 92----B-V NrdI Flavodoxin like EMFPBA- Threonyl and Alanyl tRNA synthetase second additional domainEM----- EGF-like domainEMF---- TFIIH C1-like domain----B-- FabA-like domainEM----- NIPSNAP

SusD family

Sheet1

------V Herpes UL74 glycoproteins EM----- Domain of unknown function (DUF1693) EMFP--- SRR1EMF---- Tubulin binding cofactor CEM----V Wos2 motifEMF---- Microtubule associatedE-FPBA- Acetohydroxy acid isomeroreductase, catalytic domainEMFPBA- Pyridine nucleotide-disulphide oxidoreductaseEMFPB-- Male sterility proteinEMFPB-- Myo-inositol-1-phosphate synthase----B-- Type IV secretion system proteins----B-- Protein of unknown function (DUF1694)EM---A- Peptidase family M54

Retrotransposon hot spot protein------V CMV US


Protein of unknown function (DUF1699)EM----- PHR domain

Protein of unknown function (DUF1700)EMF-B-V Cupin superfamily protein

Viral cysteine richCDP-alcohol phosphatidyltransferase 2

------V Bacteriophage protein GP30.3E-F---- Fungal mating-type pheromoneEM----- Polycystin cation channelE-F---- Fibrinogen binding protein EM----- Frog antimicrobial peptide ----B-- Domain of unknown function (DUF1705)E-F---- Protein of unknown function (DUF1706) ----B-- Siderophore-interacting FAD-binding domainEMFP--- FAD-binding domainEM----- Ant antimicrobial peptideEM----- Spider antimicrobial peptideEM----- Bee antimicrobial peptide----B-- Acyl-CoA dehydrogenase, C-terminal domainE-F-BA- HisG, C-terminal domainEMFP--- Ferric reductase NAD binding domainEMF-B-- RNA 2'-O ribose methyltransferase substrate bindingEMFP--- Sec23/Sec24 beta-sandwich domainEM----- Trematode eggshell synthesis proteinEM----- Opioids neuropeptideEM----- Attractin familyEMFP--- TOM7 familyEM----- Mitochondrial proteolipidEM----- MNLL subunitE--PB-- PetM family of cytochrome b6f complex subunit 7EM----- Xin repeat----B-- Domain of unknown function (DUF1707)E-F---- Cell division control protein 14, SIN component----B-- IlvGEDA operon leader peptide----B-- Tap RepA1 leader peptide----B-- Tetracycline resistance leader peptide----B-- Erythromycin resistance leader peptide----B-- PyrBI operon leader peptide----B-- Tryptophanese operon leader peptide

Tryptophan leader peptide

Sheet1

E-F---- Nuclear pore complex componentEMFP--- SEP domainEMFP-A- NOSIC (NUC001) domainEM----- P68HR (NUC004) repeatEM----- P120R (NUC006) repeatEM-P--- PADR1 (NUC008) domainEMFP--- UME (NUC010) domainEM----- K167R (NUC007) repeatEMF---- PMC2NT (NUC016) domainEMFPBA- DKCLD (NUC011) domainEMFP-A- Ribosomal S13/S15 N-terminal domainEM----- DTHCT (NUC029) regionEMFP-A- RS4NT (NUC023) domainEM----- BDHCT (NUC031) domainEM----- CHDNT (NUC034) domainEM----- CHDCT2 (NUC038) domainEM----- NOPS (NUC059) domain----B-- PsaX familyEMFP--- Ribosomal L30 N-terminal domainEM----- RNPHF zinc fingerEMF---- PRO8NT (NUC069), PrP8 N-terminal domainEMF---- PROCN (NUC071) domainEMF---- PROCT (NUC072) domain----B-- Entericidin EcnA/B family------V Conotoxin O-superfamilyEM----- Conotoxin I-superfamilyEM----- Magi peptide toxin family EM----- Magi 5 toxic peptide familyEM----- Scorpion calcine familyEM----- Uperin familyEM----- Metchnikowin familyEM----- Formaecin familyEM----- Pleurocidin familyEM----- Pea-VEAacid family-----A- ATP synthase epsilon subunit----B-- Cytochrome c oxidase subunit IIa familyE-F---- ATPase proteolipid familyEM----- SFI toxin familyEM----- PhTx neurotoxin familyEM----- Ptu familyEM----- Scorpion acidic alpha-KTx toxin familyEM----- Tamulustoxin familyEM----- NADH-ubiquinone oxidoreductase B12 subunit familyEMF---- Histone methylation protein DOT1 ----B-V Polysaccharide lyase family 8, N terminal alpha-helical domainE-F-B-- Mannitol dehydrogenase C-terminal domain----B-- Propeptide_C25EM----- Peptidase family C1 propeptide------V Anticodon nuclease activator family------V cIII protein family------V Major transforming protein E5 family----B-- 30S ribosomal protein subunit S22 familyEM----- Sex peptide (SP) family----B-- Prokaryotic membrane lipoprotein lipid attachment siteEM----- Crustacean cuticle protein repeatEMF---- AARP2CN (NUC121) domainEM----- CBFNT (NUC161) domain

Sheet1

EMF---- CPL (NUC119) domainEMFP--- BOP1NT (NUC169) domainEMFP--- BP28CT (NUC211) domainEMFP--- DBP10CT (NUC160) domainEMF-B-- DSHCT (NUC185) domainEMF---- BING4CT (NUC141) domainEM----- FerB (NUC096) domainEM----- FerI (NUC094) domainEMF---- NGP1NT (NUC091) domainEMFP--- NLE (NUC135) domainEMFP--- NOGCT (NUC087) domainEMFP--- NOP5NT (NUC127) domainEM----- NUC129 domainEMF---- NUC130/3NT domainEMF---- NUC153 domainEMF---- NUC173 domainEM----- NUC194 domainEMF---- TRAUB (NUC102) domainEM----- FerA (NUC095) domainEM----- NUC202 domainEM----- NUC201 domainEM----- NUC205 domainEM----- RBB1NT (NUC162) domainEMF---- POPLD (NUC188) domainEMFP--- CASP C terminalE-F---- Fungal domain of unknown function (DUF1709)EM--B-- Small acid-soluble spore protein O family----B-- GnsA/GnsB family----B-- Small acid-soluble spore protein P familyEM----- B melanoma antigen family----B-- DegQ (SacQ) familyEM----- Pedibin/Hym-346 family----B-- Stage V sporulation protein familyEM----- Cuticle protein 7 isoform familyEM----- Spermatozal protamine familyEM----- Meleagrin/Cygnin familyEMFP--- pre-RNA processing PIH1/Nop17E-F---- Peptidase family S64E-F---- INO80 complex subunit Ies4EM----- DIM protein

TRI9 protein------V UL2 proteinEM----- Thymopoietin protein

Bacteriophage E2-like proteinEMF---- Mis12-Mtw1 protein familyEM----V CD47 immunoglobulin-like domainEM----- CD80-like C2-set immunoglobulin domain ----B-- Ribonuclease B OB domain----BA- Elongation factor P (EF-P) KOW-like domainEMF---- DNA-directed RNA polymerase I subunit RPA34.5EMF---- Sgf11 (transcriptional regulation protein)EM----- APOBEC-like N-terminal domain----B-- Cytidine and deoxycytidylate deaminase zinc-binding region EM--B-V Lipocalin-like domainEMF-B-- Mitochondrial domain of unknown function (DUF1713)EMFP--- Histone acetylation proteinEMF---- Eukaryotic domain of unknown function (DUF1716)

Sheet1

EMF---- Fungal domain of unknown function (DUF1712)----B-- Citrate lyase ligase C-terminal domain----BA- DeoR-like helix-turn-helix domainEMF---- RNA polymerase III subunit RPC82 helix-turn-helix domain----B-- CodY helix-turn-helix domain

Domain of unknown function (DUF1719)EM----- Pseudin antimicrobial peptideEMF---- DASH complex subunit Hsk3 likeE-F---- RNase P subunit Pop3E-F---- ER membrane protein SH3 ------V Cpl-7 lysozyme C-terminal domainEMF---- SYF2 splicing factorEMF---- Striatin familyEMF---- LNS2 (Lipin/Ned1/Smp2)EMF---- SRI (Set2 Rpb1 interacting) domain----B-- PE-PPE domainEMFPB-V Sel1 repeat----B-- Bacterial SH3 domainEMFPBAV Alcohol dehydrogenase GroES-like domainEMFPBAV Methyltransferase domainEMF-BA- Methyltransferase domainEMF---- SPT2 chromatin proteinE-FPB-- Glycosyl hydrolases family 32 C terminalEMF-BA- Mur ligase middle domainEM-P--V Cathepsin propeptide inhibitor domain (I29)E--P--- ENOD40 proteinEM----- Mastoparan peptideE-F---- arg-2/CPA1 leader peptide ----B-- Erm Leader peptide EM----- Aurein-like antibiotic peptideEM----- Sulfakinin familyEM----- Periviscerokinin familyEM----- Carcinustatin peptideEM----- Leucophaea maderae tachykinin-related peptide E--P--- Leucine rich repeat N-terminal domainEMFPBA- Anticodon-binding domainEMF---- YL1 nuclear protein C-terminal domainEM----- Cadherin-like----B-- Cache domain----B-- M protein trans-acting positive regulator (MGA) PRD domainEMFPBAV TFIIB zinc-binding----B-- Topoisomerase I zinc-ribbon-like ------V Zinc-binding domain of primase-helicase----B-- PhnA Zinc-Ribbon ----B-V DNA primase catalytic core, N-terminal domainE--P--- PAN-like domain

PAN-like domain----B-- DNA primase DnaG DnaB-binding EM--BA- HTH domain----BA- M protein trans-acting positive regulator (MGA) HTH domain----BAV Sigma-70, region 4E-FPBA- haloacid dehalogenase-like hydrolase------V Geminivirus rep protein central domainEM----- Retroviral aspartyl proteaseEMF---- Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)EMF---- Spc24 subunit of Ndc80E-F---- Spc19

Sheet1

EMF---- PIGA (GPI anchor biosynthesis)------V Influenza Matrix protein (M1) C-terminal domain------V Hepatitis core protein, putative zinc finger----B-- Peptidase M15 EMF---- RNA polymerase III subunit Rpc25EMF---- Mitochondrial ribosomal subunit S27EMF---- TIM21EMFP--- Histone deacetylase (HDAC) interacting E-F---- U3 snoRNA associated----B-- PrkA AAA domainE-F---- Fungal tRNA ligase phosphodiesterase domainE-F---- tRNA ligase kinase domain

Glycosyl hydrolase family 98----B-- PEGA domain

LVIVD repeat----B-- LGFP repeatEMF---- Mad3/BUB1 homology region 1EMF---- cwf21EMF---- SCA7EMF---- Secretory pathway protein Sec39EMF---- cwf18 pre-mRNA splicing factor E-F---- Pal1 cell morphology proteinE-F---- Spc7 kinetochore proteinEMFP--- COG4 transport proteinEMF---- PIG-X / PBN1EMFP--- PPP5E-FPBA- Starch synthase catalytic domainEMF---- PUL domainE-F---V WLM domainEMF---- Acetyl-CoA carboxylase, central regionEMF-B-- Activator of Hsp90 ATPase homolog 1-like proteinE---B-- Adenylosuccinate lyase C-terminal----B-- Domain of unknown function (DUF1730)EM----- Calcium/calmodulin dependent protein kinase II AssociationEM----- Protein of unknown function (DUF1725)----B-- Bacterial type II secretion system protein G----B-- GlnD PII-uridylyltransferaseEM----- Prolyl 4-Hydroxylase alpha-subunit, N-terminal regionEM----- Plexin cytoplasmic RasGAP domainEM-PB-- Domain of unknown function (DUF1731)----B-- RTX C-terminal domain----B-- Domain of unknown function (DUF1732)

Fibronectin-binding protein signal sequence----B-V Ribonucleotide reductase N-terminalEM----- Transient receptor ion channel II----B-- Flagellar M-ring protein C-terminal----B-- AntA/AntB antirepressorEM----- N-terminal CTNNB1 binding----B-- YheO-like PAS domain----B-- Protein of unknown function (DUF1722)

Domain of unknown function (DUF1724)EMFPB-- Domain of unknown function (DUF1726)----B-- Oligopeptide/dipeptide transporter, C-terminal regionE-F---- Domain of unknown function (DUF1729)EMF---- EF hand associatedEMF---- EF hand associatedEM----- SEFIR domain

Sheet1

------V Carlavirus coat----B-- YsiA-like protein, C-terminal region----B-- QacR-like protein, C-terminal region----B-- MAATS-type transcriptional repressor, C-terminal regionEM----- LLGL2EMFPB-- Peptidase M16C associatedEM----- FAST kinase-like protein, subdomain 2E--PB-- Proto-chlorophyllide reductase 57 kD subunitE--P--- Plant PDR ABC transporter associatedEM----V Phospholipase D/viral envelopeEM----- Plant phosphoribosyltransferase C-terminalEM----- RAP domainEM----- ProtocadherinEMFP--- Proteasome regulatory subunit C-terminal----B-- Nitrate and nitrite sensingEM----- MAP2/Tau projection domain----B-- Nuclease-related domainEM----- Pro-opiomelanocortin, N-terminal regionEMFP--- Dynein heavy chain, N-terminal region 1----B-- TAP-like proteinE--P--- FBDE--P--- Group II intron, maturase-specific domainEMF---- Exportin 1-like proteinEMF---- TRAM1-like proteinEM----- Ly49-like protein, N-terminal regionE--P--- FAE1/Type III polyketide synthase-like proteinEMFP--- Dynein heavy chain, N-terminal region 2

Archaeal TRASH domainEM----- 7tm Chemosensory receptorEM----- Spider toxin omega agatoxin/Tx1 familyEM----- IRSp53/MIM homology domain------V Parvovirus coat protein VP1EM----- VWA N-terminal----B-V Prophage tail fibre N-terminal----B-- TOBE domainEM----- Amino acid permease N-terminal----B-- CbbQ/NirQ/NorQ C-terminal E-F---- Chitin synthase N-terminal------V DNA polymerase family B viral insertEM----- Domain of unknown function (DUF1736)----B-- Exonuclease C-terminalEM----- Ion transport protein N-terminal----B-- Calcineurin-like phosphoesterase C-terminalE--P--- Respiratory burst NADPH oxidaseEM----- Phosphotyrosine-binding domainE--P--- Pheophorbide a oxygenaseEMF---- DNA polymerase alpha subunit B N-terminalEM----- Zinc finger, C4 type, C-terminal

Hypothetical methyltransferaseEMFP-A- Rad51EMF---- Protein of unknown function (DUF1740)E-F---- ICE2EMF---- Domain of unknown function (DUF1741)----B-- Rib/alpha-like repeatEMF---- PLU-1-like proteinEM----- Forkhead N-terminal regionE-F---- Fungal protein of unknown function (DUF1742)

Sheet1

EMF--A- Chromatin associated protein KTI12 ------V Calicivirus coat protein C-terminal----B-- Glycosyl transferase family 8 C-terminalE-F--A- GTPase of unknown function C-terminal----B-- Oligopeptidase F------V Potyviridae polyproteinEM----- Integrin alphaEMFPBA- ATP-grasp domainEMF-BA- RimK-like ATP-grasp domainEM----- Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal regionEMF---- FR47-like proteinE--PB-- PAS foldEMF-B-- PAS foldEMF-B-- PAS foldEMF---- UAA transporter familyEMF-BA- SMP-30/Gluconolaconase/LRE-like regionEM----- Adenosine/AMP deaminase N-terminal------V DNA polymerase family B exonuclease domain, N-terminal----B-- Peptidase family M9 N-terminalEM----- RyR and IP3R Homology associated

Bacterial SNF2 helicase associatedViral methyltransferase C-terminal

E-F---- Sfi1 spindle body proteinPlant pleckstrin homology-like region

----BA- UvrC Helix-hairpin-helix N-terminal----B-- Bacterial SH3 domain----BA- Ribonuclease R winged-helix domain----B-- EcoEI R protein C-terminal------V Geminivirus AC4/5 conserved region------V Thymidine kinase from Herpesvirus C-terminal------V Luteovirus RNA polymerase P1-P2/replicase----B-- Methyltransferase small domain N-terminal------V Nucleoside triphosphatase I C-terminal----B-- Nontoxic nonhaemagglutinin C-terminalE--P--- Sucrose-6-phosphate phosphohydrolase C-terminalEM----- Neuronal voltage-dependent calcium channel alpha 2acdEM----- Myelin transcription factor 1------V Viral capsid protein 91 N-terminal------V Viral D10 N-terminalEMFP-AV Miro-like protein----B-- POTRA domain, FtsQ-type----B-- POTRA domain, ShlB-type

Disaggregatase related----B-- ATP-dependent helicase C-terminal----B-- IstB-like ATP binding N-terminal

C-methyltransferase----B-- Polysaccharide biosynthesis protein C-terminalEM----- Vault protein inter-alpha-trypsin-----A- Domain of unknown function (DUF1743)EMF---- Domain of unknown function (DUF1744)EMFP--- Squalene epoxidaseEMF---- SRP72 RNA-binding domainE-F---- Aflatoxin regulatory protein----BA- DEAD/H associated----B-- Peptidase family S49 N-terminal----BA- Radical SAM N-terminalEM----- 3'5'-cyclic nucleotide phosphodiesterase N-terminal

Sheet1

E-FPBA- LeuA allosteric (dimerisation) domain----BA- Tetrahydrodipicolinate succinyltransferase N-terminalE-F---- DSL1EMFP--- Cse1E-F---- COPI associated proteinE-F---- Fungal domain of unknown function (DUF1746)E-F---- Adenylate cyclase G-alpha binding domainEMFP--- PIG-PEMF---- COQ9EMFP--- Histone chaperone Rttp106-likeEMFP--- LisHEMF---- STAG domain EM----- Transforming growth factor beta type I GS-motifEM----- ADAM cysteine-richEM----- Ataxin-1 and HBP1 module (AXH)EMF---- Spa2 homology domain (SHD) of GITEMF--AV Replication factor RFC1 C terminal domain

Domain of unknown function (DUF1735)EMFP--- Multiprotein bridging factor 1EMF---- rRNA processing----B-- Opacity-associated protein A N-terminal motifEM----- Protein-arginine deiminase (PAD) middle domainE-F---- Whi5 like----B-- NusA N-terminal domain----B-- X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain

Alpha-L-rhamnosidase N-terminal domain----B-- Beta-galactosidase trimerisation domain----B-- Beta-galactosidase C-terminal domainEMFPB-- Redoxin----B-- KorB domain

Whirly transcription factorE-F---- Fungal Nap binding protein NBP1E-F---- Protein of unknown function (DUF1749)EMF---- HbrB-likeEMFPB-- Hydroxymethylglutaryl-coenzyme A synthase C terminalE--PBA- 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal EMF--AV Replication factor CE-FPBA- Phosphomethylpyrimidine kinaseEMFPBA- GHMP kinases C terminal E--PBA- 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase IIIE-F-BA- Ketopantoate reductase PanE/ApbA C terminalEMFP--- Complex I intermediate-associated protein 30 (CIA30)----B-- Peptidase M10 serralysin C terminalE-F---- Fungal domain of unknown function (DUF1750)E-F---- Fungal protein of unknown function (DUF1752)EMF---- Eukaryotic integral membrane protein (DUF1751)E-F---- Inositolphosphorylceramide synthase subunit Kei1E-FP--- VID27 cytoplasmic proteinEMF---- Eukaryotic family of unknown function (DUF1754)EMF---- Sphingolipid Delta4-desaturase (DES)EMF---- Telomere repeat binding factor (TRF)E-F---- Cut8EMF---- Mitochondrial ribosomal protein L37EM----- CrispEM----- P53 transactivation motifEMF---- Cdc37 C terminal domainEMF---- Cdc37 Hsp90 binding domain

Sheet1

E-F---- Mitochondrial import protein Pam17EMF---- TFIIH p62 subunit, N-terminal domainEMFP--- Central kinetochore-associatedEMFP--- Mo25-likeEMF---- Yos1-likeEMF---- pre-mRNA processing factor 3 (PRP3)EMFP--- DNA repair protein endonuclease SAE2/CtIP C-terminusEMF---- Protein of unknown function (DUF1762)E-F---- Domain of unknown function (DUF1763)E-F---- Eukaryotic protein of unknown function (DUF1764)EMFP--- PI31 proteasome regulator E-F---- Protein of unknown function (DUF1765)E-F---- Mitochondrial ribonuclease P subunit (RPM2)E-F---- Yeast cortical protein KAR9E-F---- Tup N-terminalEMF---- Cytochrome c oxidase biogenesis protein Cmc1 likeEMF---- Ribonuclease P 40kDa (Rpp40) subunitEMF---- Domain of unknown function (DUF1767)E-F---- RSC complex, Rsc14/Ldb7 subunitE-F---- Ubiquitin associated domain (UBA) E-F---- Protein of unknown function (DUF1769)EMF---- Domain of unknown function (DUF1771)E-F---- Ribonucleotide reductase inhibitorE-F---- Domain of unknown function (DUF1772)E-F---- Meiotically up-regulated C-terminalE-F---- RXT2-like, N-terminalEMF---- Lethal giant larvae(Lgl) like, C-terminalEMF---- Translation initiation factor eIF3 subunitEMF---- Sds3-likeEM----- DNA damage repair protein Nbs1EMF---- Rsm1-likeE-F---- Transcription factor PAP1E-F---- Mgr1-like, i-AAA protease complex subunitEMF---- Adenylate cyclase associated (CAP) C terminalEMF---- Nucleoporin Nup153-likeE-F---- Fungal Rad9-like Rad53-bindingEMFP--- Prp19/Pso4-likeE-F---- Nucleotide exchange factor Fes1EMF---- Peroxisomal membrane protein (Pex16)E-F---- Fungal protein of unknown function (DUF1774)EMF---- TATA-binding related factor (TRF) of subunit 20 of Mediator complexEMFP--- CyclinEMF---- Autophagy protein 16 (ATG16)EMF---- Ribonuclease H2 non-catalytic subunit (Ylr154p-like)E-F---- Spindle pole body interacting proteinEMF--A- Kinase binding protein CGI-121E-F---- Transcription factor Opi1E-F---- Alkali metal cation/H+ antiporter Nha1 C terminusEMF---- RPAP1-like, C-terminalEMF---- RPAP1-like, N-terminalE-F---- Svf1-likeEMF---- TATA-binding protein interacting (TIP20)E-F---- Chromatin remodelling complex subunitEMF---- Utp13 specific WD40 associated domainEMF---- Transport protein Trs120

CRT-likeEMF---- Sorting nexin C terminal

Sheet1

EM----- PDE8 phosphodiesteraseE-F---- Dfp1/Him1, central regionEMF---- Meiosis protein SPO22/ZIP4 likeE-F---- Mitochondrial protein Pet127EMF---- Mediator complex subunit MED14E-F---- DNA replication regulator SLD3EMF---- U3 small nucleolar RNA-associated protein 6EMF---- Kinetochore protein Mis14 likeE-F---- Histone deacetylation protein Rxt3E-F---- Fungal family of unknown function (DUF1776)EMFP--- FACT complex subunit (SPT16/CDC68)EMF-BAV Polynucleotide kinase 3 phosphataseEMF--A- Replication factor-A C terminal domainEMF---- BRE1 E3 ubiquitin ligaseEMF---- Protein of unknown function (DUF1777)E-F---- DASH complex subunit Dad1E-F---- DASH complex subunit Dad4E-F---- DASH complex subunit Duo1EMFP--- RAI1 likeE-F---- DASH complex subunit Dam1E-F---- DASH complex subunit Dad2E-F---- DASH complex subunit Ask1E-F---- DASH complex subunit Dad3E-F---- DASH complex subunit Spc34 EMF---- Rad54 N terminalEMF-B-- KR domainEMF---- Oligosaccharide biosynthesis protein Alg14 likeEMF---- Replication factor A protein 3EMFP--- Eukaryotic translation initiation factor eIF2A

HalX domain----B-- YcbB domain

PglZ domainEM--BA- SAF domain

BetR domainEMFPBA- Glycine cleavage T-protein C-terminal barrel domainE--P--- MEKHLA domain----B-- Anti-repressor SinIEMF---- Anaphase promoting complex (APC) subunit 2----B-- Phosphoserine phosphatase RsbU, N-terminal domainEM----- Acetylcholinesterase tetramerisation domainEM----- RNA binding domainEMF-BA- MutL C terminal dimerisation domain----B-- Rsbr N terminal----BA- Dissimilatory sulfite reductase D (DsrD)----B-- Protein of unknown function (DUF1779)----B-- Protein of unknown function (DUF1778)EM----- Microtubule-binding calmodulin-regulated spectrin-associated------V DNA mimic ocrEM----- GON domainEM----- PLAC (protease and lacunin) domainEM----- Apx/Shroom domain ASD2EM----- Apx/Shroom domain ASD1E-F---- GET complex subunit GET2E-F---- DNA repair protein Nse5E-F---- Transmembrane alpha-helix domainEM----- Ubiquitin-fold modifier-conjugating enzyme 1E-F---- Fungal protein of unknown function (DUF1783)

Sheet1

EMF---- DNA replication factor Dna2EMF---- Fcf2 pre-rRNA processingEMFP--- Domain of unknown function (DUF1785)EMF---- Vps51/Vps67EMF---- GNL3L/Grn1 putative GTPaseEM----- Fibrinogen alpha/beta chain familyEM----- PLC-beta C terminalEMF-BA- tRNA methyltransferase complex GCD14 subunit------V D5 N terminal like------V Primase C terminal 2 (PriCT-2) EM----- Inositol 1,4,5-trisphosphate/ryanodine receptorEMF---- TFIIS helical bundle-like domainEMFPB-- Scaffold protein Nfu/NifU N terminal----B-- DNA alkylation repair enzyme----BA- Formaldehyde-activating enzyme (Fae)------V Papain like viral protease------V nsp7 replicase------V nsp8 replicaseEM----- Glycolipid transfer protein (GLTP)EM--B-V Domain of unknown function (DUF1768)------V Influenza C hemagglutinin stalk----B-- TnsA endonuclease C terminal----B-- TnsA endonuclease N terminalEM----- Integrin beta cytoplasmic domainEMF---- Ca2+ insensitive EF hand------V Poliovirus 3A protein likeE-F---- CRT10E-F---- Histone promoter control 2 (HPC2)E-F---- Rad33E-F---- Transcription factor AFTE-F---- PalH/RIM21

GYD domainPutative pyruvate format-lyase activating enzyme (DUF1786)

EM----- FERM adjacent (FA)EMF---- Rgp1E-F---- Gon7 familyEMF---- BCS1 N terminal----B-- YwhD familyEM----- C8 domainEMF---- Nse4----BA- UPF0278 familyEMF---- RING-like domain

Domain of unknown function (DUF1788)Domain of unknown function (DUF1789)Family of unknown function (DUF1790)

EMFP--- Coatomer gamma subunit appendage domain----BA- NikR C terminal nickel binding domainEM--B-- Hemimethylated DNA-binding protein YccV like----B-- CotH proteinEM----- Cadherin prodomain like

Domain of unknown function (DUF1792)Domain of unknown function (DUF1793)

------V dUTPase------V CRPV capsid protein likeEM----- Voltage gated calcium channel IQ domain----B-- Staphylococcus aureus coagulase----B-V Mor transcription activator family

Sheet1

EMFP--- DEK C terminal domainEMF---- CRM1 C terminalEM-PB-- Domain of unknown function (DUF1794)----B-- Sporulation initiation factor Spo0A C terminal

Sulphur oxidation protein SoxZEMF---- Rapamycin binding domainEMF---- Nin one binding (NOB1) Zn-ribbon likeEM----- Cathepsin C exclusion domainEMF-B-V VRR-NUC domain----B-- ParB familyEM----- VASP tetramerisation domainEM----- RNA binding motif------V SARS coronavirus X4 like----B-- Nucleotidyltransferase substrate binding protein likeEM----- Transcription factor DPEM----V c-SKI Smad4 binding domainEMF---- DWNN domainEMF---- Replication protein A C terminalEMF---- Ku C terminal domain like----B-- Domain of unknown function (DUF1795)E--PB-- Alginate lyaseEM----- NHR2 domain likeEMF---- LYAR-type C2HC zinc finger ------V A2L zinc ribbon domain------V 2-cysteine adaptor domain

Lipoprotein GNA1870 C terminal like------V Putative papain-like cysteine peptidase (DUF1796)----B-- Protein of unknown function (DUF1797)EMFP--- HIRAN domainEMFP--- pre-mRNA processing factor 4 (PRP4) likeEMF---- Nup133 N terminal likeE--PB-- Cytochrome B6-F complex Fe-S subunit ----B-- Putative mono-oxygenase ydhR------V gp32 DNA binding protein likeEM----- Sep15/SelM redox domain----B-- Bacterial domain of unknown function (DUF1798)----B-- Kinase associated protein B

Protein of unknown function (DUF1800)----B-- YtxC-like familyEM----- Nuclear receptor coactivator

Domain of unknown function (DU1801)Domain of unknown function (DUF1803)

-----A- CGGC domainProtein of unknown function (DUF1804)Putative peptidoglycan binding domain

EM----- Serine rich protein interaction domainEMFP--- E2 binding domainEM----- DMPK coiled coil domain like

Domain of unknown function (DUF1805)EM----- Doublesex dimerisation domain----B-- Alpha C protein N terminalEM----- Class II MHC-associated invariant chain trimerisation domainEM----- Steroid receptor coactivatorEM----- Axin beta-catenin binding domain


EMF---- DNA replication factor CDT1 like

Sheet1

EMF-B-- BAAT / Acyl-CoA thioester hydrolase C terminalDiol dehydratase reactivase ATPase-like domain

----B-- Domain of unknown function (DUF1814)Domain of unknown function (DUF1815)Domain of unknown function (DUF1816)Domain of unknown function (DUF1817)Domain of unknown function (DUF1818)Putative inner membrane protein (DUF1819)Domain of unknown function (DUF1820)Protein of unknown function (DUF1822)Domain of unknown function (DUF1823)Domain of unknown function (DUF1824)Domain of unknown function (DUF1825)Protein of unknown function (DUF1826)Putative ParB-like nuclease

----B-- IDEAL domainDomain of unknown function (DUF1827)Domain of unknown function DUF1828Domain of unknown function DUF1829

----B-- YolD-like protein----B-- UPF0302 domain----B-- Domain of unknown function (DUF1830)

Domain of unknown function (DUF1831)----B-- YugN-like family

XisI proteinDomain of unknown function (DUF1832)KGK domainDomain of unknown function (DUF1835)Domain of unknown function (DUF1833)

----B-- Domain of unknown function (DUF1836)MepB protein

----B-- Domain of unknown function (DUF1837)WRC

EMFP--- QLQ----B-- CVNH domain

Acetone carboxylase gamma subunitE-F---- Dopa 4,5-dioxygenase family----B-- Flagellin D3 domain

GSCFA familyGAD-like domainHopJ type III effector protein

----B-- WbqC-like protein family----B-- Phage XkdN-like protein----B-- YfcL protein

Domain of unknown function (DUF1839)Domain of unknown function (DUF1840)Domain of unknown function (DUF1842)Domain of unknown function (DUF1843)Domain of unknown function (DUF1844)Domain of unknown function (DUF1845)

-----A- Protein of unknown function (DUF1847)----B-- Domain of unknown function (DUF1846)

Domain of unknown function (DUF1850)Domain of unknown function (DUF1851)Domain of unknown function (DUF1853)Domain of unknown function (DUF1852)Domain of unknown function (DUF1854)

Sheet1

EM----- Protein of unknown function (DUF1855)EMF---- NUP50 (Nucleoporin 50 kDa)EM----- Rho BindingEM----- Vinculin Binding SiteEM----- Rap1 Myb domain-----A- Archaea-specific editing domain of threonyl-tRNA synthetaseEM----- Phenylalanine zipperEM----- Transforming growth factor beta receptor 2 ectodomain----B-- PhoQ SensorEM----V F-actin bindingEMF---- Splicing factor 3B subunit 1


EM----- Mitogen-activated protein kinase kinase 1 interactingEM----- Domain of Unknown Function (DUF1907)EM----- Domain of unknown function (DUF1908)

Domain of unknown function (DUF1910)Domain of unknown function (DUF1911)Domain of unknown function (DUF1914)Domain of unknown function (DUF1864)

EM----- Rb C-terminal domain------V Domain of unknown function (DUF1865)

MTH538 TIR-like domain (DUF1863)EM----- Domain of unknown function (DUF1916)EM----- Domain of unknown function (DUF1917)----B-- Domain of unknown function (DUF1918)EM----- USP8 interacting----B-- Domain of unknown function (DUF1919)----B-- CsiDEM----- NADPH oxidase subunit p47Phox, C terminal domain----B-- Osmosensory transporter coiled coilEM----- BPS (Between PH and SH2) ------V Domain of unknown function (DUF1860)

Protein of unknown function (DUF1861)----B-- Enterocin A ImmunityEM----- Domain of unknown function (DUF1866) EMF---- Domain of unknown function (DUF1899)EMF---- Domain of unknown function (DUF1900)----B-- Domain of unknown function (DUF1871)EM----- Domain of unknown function (DUF1872)EM----- Domain of unknown function (DUF1875)----B-- Protein of unknown function (DUF1878)E------ Protein of unkown function (DUF1881)----B-- Domain of unknown function (DUF1870)-----A- Domain of unknown function (DUF1884)

Domain of unknown function (DUF1885)EM----- Domain of unknown function (DUF1873)----B-- Sporulation inhibitor A----B-- Glycogen synthesis protein


----B-- Domain of unknown function (DUF1877)EM----- Domain of unknown function (DUF1880)

Reoviridae VP9Domain of unknown function (DUF1883)Domain of unknown function (DUF1857)

EM----- Domain of unknown function (DUF1856)

Sheet1


E-F---- Protein of unknown function (DUF1892)----B-- Erythronolide synthase dockingEMF---- Domain of unknown function (DUF1903)------V T4 gene 59 helicase, N terminal------V T4 gene 59 helicase, C terminal

Necrosis inducing protein-1EMFP--- DNA Polymerase alpha zinc fingerEM----- Ubiquinol-cytochrome C reductase complex, 6.4kD protein----B-- Bacterial epsilon antitoxinEM----- Surfactant protein C, N terminal propeptide----B-- Cytotoxic-----A- Domain of unknown function (DUF1890)

Domain of unknown function (DUF1887)EM----- Domain of unknown function (DUF1891)EM----- Domain of unknown function (DUF1897)EM----- Lung surfactant protein D coiled-coil trimerisationEM----- EBP50, C-terminal----B-V Head binding------V Anti-Sigma Factor AEM----- Domain of unknown function (DUF1898)----B-- FeoC like transcriptional regulator----B-- YopH, N-terminalEM----- Beta-2-glycoprotein-1 fifth domain----B-- NgoMIV restriction enzyme

Pas factor saposin fold----B-- Microbial transglutaminase----B-- EcoRII C terminal----B-- YopE, N terminalEM----- Centromere protein B dimerisation domainEM----- GTPase binding

Mac 1EM----- 5-aminolevulinate synthase presequenceEM----- Creb bindingEM----- Siah interacting protein, N terminal EM----- DNA Fragmentation factor 45kDa, C terminal domainEM----- TRADD, N-terminal domain----B-- Excisionase from transposon Tn916EM----- Bcr-Abl oncoprotein oligomerisation domain

Stf0 sulphotransferaseEM----- Tumour suppressor p53-binding protein-1 Tudor----B-V Mu DNA binding, I gamma subdomainEM----- Aurora-A binding EM----- Titin Z

D-Lysine 5,6-aminomutase alpha subunit------V Kp4EM----- L27_2----B-- AvrPtoB E3 ubiquitin ligaseEM----- MEF2 binding------V CroEM----- Stannin transmembraneEM----- Stannin cytoplasmic----B-- Nickel-containing superoxide dismutaseEM----- Second Mitochondria-derived Activator of CaspasesEM----- L27_1----B-- TyeA

Sheet1

EM----- L27_NStirrupPI-PfuI Endonuclease subdomain

EM----- Thrombomodulin like fifth domain, EGF-likeEM----- Beta2-adaptin appendage, C-terminal sub-domainEM----- Erythropoietin receptor, ligand bindingEM----- EF handEM----- EF-handEMF---- PFU (PLAA family ubiquitin binding)

Alpha-amylase, C terminalEMF---- Translation machinery associated TMA7EMF---- BUD22E-F---- Mer2----B-- Heat-stable enterotoxin B, secretory

Streptomyces killer toxin-like----B-- CheY bindingEMF--A- CDC6, C terminal

K cyclin, C terminal----B-- Domain of unknown function (DUF1921)E-F-B-- NMT1/THI5 likeEM----- Adhesion molecule, immunoglobulin-likeEMF---- MIF4G likeEMF---- MIF4G like----B-- Lyase, N terminal----B-- Lyase, catalytic----BA- Domain of unknown function (DUF1925)----BA- Domain of unknown function (DUF1926)------V Baseplate structural protein, domain 2

Bacterial Ig-like domain (DUF1927)Domain of unknown function (DUF1928)

----B-- Exotoxin A, targetingEM----- BRCA2, oligonucleotide/oligosaccharide-binding, domain 1EM----- BRCA2, oligonucleotide/oligosaccharide-binding, domain 3----B-- Elongation factor SelB, winged helix EM----- Switch protein XOL-1, N-terminalEMFP--- HANDEMFP--- SLIDE----B-- Peptide-N-glycosidase F, C terminal------V Transcription factor MotA, activation domain----B-- DNA polymerase III, delta subunit, C terminalE--P--- MiAMP1EM----- Tower----BA- Domain of unknown function (DUF1931)----B-- Cytochrome C oxidase subunit II, transmembrane----B-- Restriction endonuclease NaeI EMF---- Leukotriene A4 hydrolase, C-terminalEM----- Regulator of G protein signalling-like domain-----A- Domain of unknown function (DUF1932)EM----- SANTA (SANT Associated)E-F---- Alb1EMFP--- Urm1 (Ubiquitin related modifier)EMF---- Mitochondrial matrix Mmp37E-F-BA- ATPase MipZEM----- Talin, middle domain----B-- tRNA Pseudouridine synthase II, C terminal

Yersinia pseudotuberculosis mitogenEM----- BmKK2 toxic

Sheet1


----B-- Orange carotenoid protein, N-terminal Domain of unknown function (DUF1936)Domain of unknown function (DUF1937)

-----A- Domain of unknown function (DUF1938)Domain of unknown function (DUF1940)

----B-- Anthrax toxin lethal factor, middle domain------V Bacteriophage T4 MotA, C-terminalE-F---- Mitochondrial resolvase Ydc2, catalytic----B-- FimH, mannose bindingEM----- Tap, RNA-binding----B-- Formate dehydrogenase N, transmembraneEM----- Vitamin D binding protein, domain IIIEM----- Ubiquinol-cytochrome c reductase 8 kDa, N-terminalEM----- Biliverdin reductase, catalyticEM----- BRCA2, helicalEM----- Domain of unknown function (DUF1879)-----A- Domain of unknown function (DUF1886)EM----- Domain of unknown function (DUF1943)EMF--A- Initiation factor eIF2 gamma, C terminalEMF---- Maf1 regulatorEM----- Domain of unknown function (DUF1944)EMFP--- Syntaxin 6, N-terminal----B-- Domain of unknown function (DUF1945)----B-- TilS substrate binding domainEMF-BA- Prolyl-tRNA synthetase, C-terminal-----A- Prolyl-tRNA synthetase, C-terminal----B-- Bacterial purine repressor, N-terminal

Domain of unknown function (DUF1947)EMF---- PPP4R2----B-- Domain of unknown function (DUF1949)E--P--- Domain of unknown function(DUF1950)----B-- Domain of unknown function (DUF1951)EM--BA- DALR domainE------ Actin-fragmin kinase, catalyticEM----- Cholecystokinin A receptor, N-terminal----B-- Restriction endonuclease BsobI----B-- Restriction endonuclease BglII

Domain of unknown function (DUF1953)E-F---- Rap1, DNA-binding------V Bacteriophage T4 beta-glucosyltransferaseE-F---- SRXEMF--A- Rio2, N-terminal

MspA----B-- Colicin D

Domain of unknown function (DUF1955)----B-- Domain of unknown function (DUF1956)

Domain of unknown function (DUF1957)Domain of unknown function (DUF1958)Pfg27

-----A- Domain of unknown function (DUF1959)------V L-A virus, major coat protein

Bacteriocin class IId cyclical uberolysin-like----B-- Restriction endonuclease PvuIIE-F---- Domain of unknown function (DUF1962)----B-- Prokaryotic Transcriptional repressor TraM

Sheet1

EMF---- Activator of Hsp90 ATPase, N-terminalEM----- DNA fragmentation factor 40 kDa------V Rice dwarf virus p3EM----- Caenorhabditis elegans Her-1E-F---- Ste50p, sterile alpha motifEM----- Alpha-haemoglobin stabilising proteinEM----- GAGA factorEM----- Interleukin-4 receptor alpha chain, N-terminalE--P-A- Topoisomerase VI B subunit, transducerEM----- Interleukin-6 receptor alpha chain, binding------V Herpesviridae viral cyclinEMF---- Mitochondrial small ribosomal subunit Rsm22

Domain of unknown function (DUF1964)Mycoplasma arthritidis-derived mitogen

EM----- PHATEM-P--- TATA box-binding protein binding

Domain of unknown function (DUF1965)-----A- tRNA nucleotidyltransferase, second domainEM----- Allergen Fel d I-B chain----B-- Restriction endonuclease FokI, C terminal----B-- Caf1 Capsule antigenEM----- BAFF-R, TALL-1 bindingEM----- BCMA, TALL-1 bindingEM----- Glycosyl transferase family 64 domainEMF-B-- Alpha mannosidase, middle domainEMF---- Peroxisome biogenesis factor 1, N-terminal EM----- Peroxisome biogenesis factor 1, N-terminal ----B-- Vibrio cholerae sialidase, lectin insertion------V Viral DNA topoisomerase I, N-terminalE------ Dictyostelium STAT, coiled coilEMF---- Clathrin, heavy-chain linker----B-- Domain of unknown function (DUF1967)EMF---- Beta-trefoilEMF---- LAG1, DNA bindingEM----- Hepsin, SRCREM-P--- Rubisco LSMT substrate-binding

ParG----B-- Erythronolide synthase, docking----B-- MerR, DNA bindingEMFP--- Phosphoinositide-specific phospholipase C, efhand-likeEMFP--- XPC-binding domainEMF---- Mago bindingE-F---- Rhamnogalacturonase B, N-terminal----B-- Elongation factor P, C-terminalEMF-B-- Pro-kumamolisin, activation domain EM----- CEP-1, DNA bindingE-F---- Fungal ubiquitin-associated domain EM----- Follistatin/Osteonectin-like EGF domain----B-- Prokaryotic acetaldehyde dehydrogenase, dimerisationEM----- Domain of unknown function (DUF1968)EM----- Endonuclease VIII-like 1, DNA bind------V T4 RNase H, C terminalEM----- Interferon-alpha/beta receptor, fibronectin type IIIE-F---- ChAPs (Chs5p-Arf1p-binding proteins)EMFPB-- NADH pyrophosphatase zinc ribbon domainEMF---- Domain of unknown function (DUF1969)----B-V Mu transposase, C-terminal

Sheet1

EMF---- XLF (XRCC4-like factor)E------ Cortexillin I, coiled coilEM----- TACI, cysteine-rich domain------V Bacteriophage, scaffolding proteinEM----- CLIP, MHC2 interactingEM----- FCP1, C-terminalEM----- POU domain, class 2, associating factor 1EM----- Rab5 binding----B-- SurA N-terminal domain----B-- Domain of unknown function (DUF1971)EM----- Domain of unknown function (DUF1973)EM----V C-myb, C-terminal----B-- Domain of unknown function (DUF1974)----B-- Domain of unknown function (DUF1975)EMFP--- Domain of unknown function (DUF1977)

Domain of unknown function (DUF1978)----B-- Domain of unknown function (DUF1980)EMF---- Domain of unknown function (DUF1981)EMF---- Vps5 C terminal likeEMFPB-- Domain of unknown function (DUF1982)E--P--- Domain of unknown function (DUF1984)EMF---- Primase zinc finger----B-- D-lactate dehydrogenase, membrane binding

Domain of unknown function (DUF1985)EM----- Mcm10 replication factorEMF---- ATG C terminal domainEMFPBAV tRNA synthetases class I (M)EMFPBA- SNARE associated Golgi proteinEMFP-A- Vps4 C terminal oligomerisation domainEMF---V His(2)-Cys(2) zinc finger----B-- Glycine/sarcosine/betaine reductase component B subunits----BA- IclR helix-turn-helix domainEMF---- Histone acetyltransferase subunit NuA4EMF---- Transcription factor Pcc1EM----- Domain of unknown function (DUF1986)

Conserved hypothetical protein 2217 (DUF2460)Domain of unknown function (DUF1987)

E-F-B-- SMI1 / KNR4 familyE-F-B-- Domain of unknown function (DUF1989)E--PB-- Domain of unknown function (DUF1990)EM-PB-- OHCU decarboxylaseEM--B-- Domain of unknown function (DUF1992)


EM----- HNF3 C-terminal domain------V Phage protein Gp19/Gp15/Gp42----B-- Phage conserved hypothetical protein BR0599

RteC proteinEMFP--- Ubiquitin-activating enzyme e1 C-terminal domainE-F---- VTC domainEM----- Iron-binding zinc finger CDGSH type----B-- Phasin proteinE-F-B-- XFP C-terminal domainE-F-B-- XFP N-terminal domain----B-- Protein of unknown function (DUF1997)E---B-- CpeS-like proteinEMF---- Sas10 C-terminal domain

Sheet1

E-F-BA- Domain of unknown function (DUF1998)EMF-B-- Tex-like protein N-terminal domain------V PRANC domain

Pseudomurein-binding repeatPredicted Peptidoglycan domain

----B-- Imelysin-----A- NurA domainEMF--A- SBDS protein C-terminal domainE--PBA- HAS barrel domainEM----- FERM N-terminal domain EM----- FERM C-terminal PH-like domainEMF-B-V RQC domainEMF---- UTP15 C terminal----B-- Histidine kinase N terminal----B-- Antitoxin ParDEM----- Mitochondrial RNA binding protein MRP----B-- Spo0E like sporulation regulatory protein

Protein of unknown function (DUF2000)----B-- Type III secretion needle MxiH likeE------ Chagasin family peptidase inhibitor I42EM----- Thrombin light chain----B-- Ftsk gamma domainEM----- FOP N terminal dimerisation domain------V SARS lipid binding proteinEMF---- Man1-Src1p-C-terminal domain

Adhesion protein FadAEM----- Eukaryotic protein of unknown function (DUF2003)EM----- CASC3/Barentsz eIF4AIII binding


EM----- PUB domainLipid A 3-O-deacylase (PagL)

EM----- Endoribonuclease XendoUEMF---- Protein of unknown function (DUF2008)EMFP--- RNA helicase (UPF2 interacting domain)E-F---- Protein of unknown function EMF---- Ribosome biogenesis protein Nop16E-F---- Frequency clock proteinEM----- WTX protein----B-- PhoD-like phosphataseE-F-B-- Yqey-like proteinE-F---- Vacuolar R-SNARE Nyv1 N terminalE-F---- Fungal protein of unknown function (DUF2011)EMF---- WW domain binding protein 11EMFP--- Protein of unknown function (DUF2012)EMF---- Protein of unknown function (DUF2013)E-F---- Tho complex subunit THP2E-F---- THO complex subunit HPR1E-F---- Fungal protein of unknown function (DUF2015)E-F---- Pombe specific 5TM protein----B-- Domain of unknown function (DUF2017)EMF---- Signal recognition particle receptor beta subunitEMF---- eIF3 subunit 6 N terminal domain

Domain of unknown function (DUF2018)EM----- Cripto_Frl-1_Cryptic (CFC)E-F---- MRC1-like domainEMF---V RNA cap guanine-N2 methyltransferase

Sheet1

EMF---- VMA21-like domainE-F---- Cnl2/NKP2 family protein

Methylmuconolactone methyl-isomerase Domain of unknown function (DUF2019)

E-F---- Autophagy-related protein 27E-F---- ESCRT-I subunit Mvb12EMF---- HIRA B motifEMFP--- Vps23 core domain-----A- CRISPR-associated (Cas) DxTHG family----B-- RcsC Alpha-Beta-Loop (ABL)EM----- FIP domain E---B-- H-type lectin domain

Saf-pilin pilus formation proteinPhytotoxin PcF protein

E-F---- Mus7/MMS22 familyE-F---- Opy2 proteinEM-P--- Lamin-B receptor of TUDOR domain----B-- Hypothetical protein YqaiEMF---- Ydr279p protein family (RNase H2 complex component)EM----- Cordon-bleu domain

IgA Peptidase M64-----A- Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF)

Dot/Icm secretion system protein (dot_icm_IcmQ)----B-- Pilus biogenesis CpaD protein (pilus_cpaD)----B-- Bacterial type II secretion system chaperone protein (type_III_yscG)E--P--- Carbohydrate binding domain CBM49----B-- Listeria-Bacteroides repeat domain (List_Bact_rpt)----B-- Type III secretion system protein PrgH-EprH (PrgH)----B-- Type III secretion protein (HpaP)

CRISPR-associated protein TM1802 (cas_TM1802)----B-- CRISPR-associated protein Cse2 (CRISPR_cse2)

Bacterial type III secretion protein (HrpB7)Bacterial type III secretion protein (HrpB2)

-----A- Mannosyl-3-phosphoglycerate synthase (osmo_MPGsynth)Probable cobalt transporter subunit (CbtB)Probable cobalt transporter subunit (CbtA)

----B-- AlwI restriction endonucleaseTryptophan-rich protein (DUF2389)

E-F---- Slx4 endonucleaseEMF---- Protein of unknown function (DUF2462)EMF---- Cenp-O kinetochore centromere componentEMF---- Transcription mediator complex subunit Med12

Protein of unknown function (DUF2388)----B-- Probable sporulation protein (Bac_small_yrzI)----B-- Bsp6I restriction endonuclease----B-- Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase)EMF---- DNA polymerase subunit Cdc27E-F---V RNA ligase

Thiamine-precursor transporter protein (ThiW)EM----- SSXRD motif----B-- CfrBI restriction endonuclease

Eco29kI restriction endonuclease----B-- HindVP restriction endonuclease----BA- MjaII restriction endonuclease

Protein of unknown function (DUF2390)Conserved phage C-terminus (Phg_2220_C)

----B-- Probable metal-binding protein (DUF2387)

Sheet1

Putative F0F1-ATPase subunit (ATPase_gene1)----B-- Integral membrane protein (intg_mem_TP0381)-----A- CRISPR-associated protein (cas_TM1812)EMF---- Nucleoporin protein Ndc1-NupEMF---- DFDF motif

Predicted lipoprotein of unknown function (DUF2380)Tryptophan-associated transmembrane protein (Trp_oprn_chp)Protein of unknown function (Gmx_para_CXXCG)Domain of unknown function (DUF2383)Protein of unknown function (FYDLN_acid)Protein of unknown function (DUF2385)

EMF---- FFD and TFG box motifsProtein of unknown function (DUF2381)

----B-- Stage III sporulation protein AE (spore_III_AE)----B-- Stage IV sporulation protein A (spore_IV_A)----B-- Stage III sporulation protein AB (spore_III_AB)

Bpu10I restriction endonucleaseConserved hypothetical phage protein (DUF2376)

----B-- Stage II sporulation protein R (spore_II_R)BstXI restriction endonuclease

----B-- Eco47II restriction endonuclease----B-- HaeII restriction endonuclease

Protein of unknown function (DUF2375)Cas6 Crispr

----B-- Sporulation protein YunB (Spo_YunB)----B-- NgoFVII restriction endonuclease----B-- SacI restriction endonuclease-----A- MjaI restriction endonuclease----B-- XamI restriction endonuclease----B-- TaqI restriction endonuclease

Protein of unknown function (Duf2374)----B-- Small spore protein J (Spore_SspJ)E-F---- Cytochrome c oxidase subunit COX9----B-- Sporulation protein YpjB (SpoYpjB)----B-- Spore cortex protein YabQ (Spore_YabQ)

Sporulation protein YtfJ (Spore_YtfJ)----B-- Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)----B-- Stage III sporulation protein AF (Spore_III_AF)----B-- Iron only nitrogenase protein AnfO (AnfO_nitrog)----B-- Phage shock protein G (Phageshock_PspG)----B-- Phage shock protein PspD (Phageshock_PspD)

Conserved hypothetical protein (Lin0512_fam)----B-- Bacterial membrane protein YfhO----B-- Bacterial capsule synthesis protein PGA_cap----B-V YqaJ-like viral recombinase domain----B-- HrpA pilus formation protein

Protein of unknown function (DUF2031)Beta-satellite pathogenicity beta C1 proteinProtein of unknown function (DUF2029)Metaviral_G glycoprotein

EM----- MamL-1 domainE-F---- IGR protein motifE-F---- Stm1----B-- Salmonella-Shigella invasin protein C (IpaC_SipC)----B-- Cyd operon protein YbgE (Cyd_oper_YbgE)

Protein of unknown function (DUF2459)Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg)

Sheet1

----B-- F subunit of K+-transporting ATPase (Potass_KdpF)Hypothetical bacterial integral membrane protein (Trep_Strep)

EM----- ARC105 or Med15 subunit of Mediator complex non-fungalEM----- Brinker DNA-binding domain

Putative transmembrane protein (Alph_Pro_TM)CRISPR-associated protein, GSU0054 family (Cas_GSU0054)Mycoplasma virulence signal region (Myco_arth_vir_N)CRISPR-associated protein (Cas_Csy1)Bacterial type III secretion protein (HrpB1_HrpK)CRISPR-associated protein (Cas_Csy2)CRISPR-associated protein GSU0053 (Cas_GSU0053)CRISPR-associated protein (Cas_Csy4)

----B-- Type III secretion system lipoprotein chaperone (YscW)----B-- Type III secretion system regulator (LcrR)

Putative integral membrane protein (DUF2391)Protein of unknown function (DUF2393)VP9 proteinDihaem cytochrome c

----B-- YvfG proteinDomain of unknown function (DUF2024)

EM----- Sen15 proteinProtein of unknown function (DUF2023)Protein of unknown function (DUF2025)

E-F---- MetRS-N binding domain----B-V XkdW proteinEMF---- Med18 protein

Ph1570 protein----B-- YjcQ protein

Protein of unknown function (DUF2026)----B-- Mg296 proteinEMF---- Histone chaperone domain CHZ

Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn)CRISPR-associated protein (Cas_APE2256)Putative CRISPR-associated protein (Cas_VVA1548)Protein of unknown function (DUF2396)Putative transmembrane protein (PGPGW)CRISPR-associated protein Csx8 (Cas_Csx8)CRISPR-associated protein (Cas_Csx9)CRISPR-associated protein (Cas_Csm6)Protein of unknown function (DUF2397)Protein of unknown function (DUF2398)Phenylphosphate carboxylase gamma subunit (Phenyl_P_gamma)

----B-- Amidohydrolase ring-opening protein (Amido_AtzD_TrzD)EM----- Sororin proteinEM----- Domain of unknown function (DUF2028)EMF---- Aspartyl protease----B-V Phage regulatory protein Rha (Phage_pRha)

CRISPR-associated protein (Cas_Cas02710)----B-- Spore coat protein (Spore_GerQ)----B-- Type-F conjugative transfer system pilin assembly protein

Protein of unknown function (DUF2400)------V Chlamydia-phage Chp2 scaffold (Chlamy_scaf)----B-- Type IV conjugative transfer system lipoprotein (TraV)----B-- Type-F conjugative transfer system protein (TrbI_Ftype)----B-- Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)

Protein of unknown function (Tiny_TM_bacill)N-terminal phage replisome organiser (Phage_rep_org_N)

Sheet1

Phage holin protein (Holin_LLH)------V Phage tail protein (Tail_P2_I)E---BA- Chloroplast import component protein (Tic20)

Plasmid protein of unknown function (Plasmid_RAQPRD)Protein of unknown function (P_fal_TIGR01639)Protein of unknown function (Wx5_PLAF3D7)Plasmodium yoelii repeat (PY_rept_46)Plasmodium yoelii subtelomeric region (PYST-C1)

----B-- Bacterial chaperone lipoprotein (PulS_OutS)E-F---- Argonaute siRNA chaperone (ARC) complex subunit Arb1----B-- Phage uncharacterised protein (Phage_XkdX)

Bacterial protein of unknown function (Gcw_chp)----B-- Bacterial protein of unknown function (YtfJ_HI0045)EMF---- Ctf8

Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH)----B-- Doubled CXXCH motif (Paired_CXXCH_1)----B-- CRISPR-associated protein (Cas_Cmr5)

CRISPR-associated protein (Cas_Csa5)-----A- CRISPR-associated protein (Cas_Csa4)----B-- CRISPR-associated protein (Cas_CXXC_CXXC)----B-- CRISPR-associated protein (Cas_Cas2CT1978)

Treponema clustered lipoprotein (Trep_dent_lipo)----B-- Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E)

Plant protein 1589 of unknown function (A_thal_3526)Plasmodium protein of unknown function (Plasmod_dom_1)Malarial early transcribed membrane protein (ETRAMP)

------V Lambda phage tail tape-measure protein (Tape_meas_lam_C)----BA- Putative redox-active protein (C_GCAxxG_C_C)

Putative addiction module component----B-- Protein of unknown function (DUF2384)----B-V Zinc ribbon domainEMF---- Uncharacterized conserved protein (DUF2036)EM----- Folate-sensitive fragile site protein Fra10Ac1EM----- Transmembrane proteinEM----- Cortactin-binding protein-2EM----- Myosin-like coiled-coil proteinE-F---- Gti1/Pac2 familyEM----- Microtubule-associated protein Bicaudal-DEMF---- Mitochondrial inner membrane proteinEMF---- Cactus-binding C-terminus of cactin proteinEM-P--- VEFS-Box of polycomb proteinEMF---- RNA polymerase III transcription factor (TF)IIIC subunitEM-P--- Membrane-associated apoptosis proteinEMF---- Pre-mRNA-splicing factor of RES complexEM-P--- De-etiolated protein 1 Det1EM----- Double stranded RNA binding protein (DUF2051)EMF---- Conserved membrane protein (DUF2044)EM----- Uncharacterized conserved protein (DUF2043)EM----- Uncharacterized conserved protein (DUF2045)EM----- Dyggve-Melchior-Clausen syndrome proteinEM----- Uncharacterized conserved protein (DUF2042)EM----- JNK_SAPK-associated protein-1EMF---- Coiled-coil domain-containing protein 55 (DUF2040)EM----- Tumour-associated proteinEM----- Coiled-coil domain containing protein (DUF2052)EMF---- Transcription factor subunit Med10 of Mediator complexEMF---- Uncharacterised conserved protein

Sheet1

EM----- Alternative splicing regulator EMF---- Nuclear protein Es2EM--B-- Uncharacterized conserved protein (DUF2048)EMF---- Membrane fusion protein Use1EMF--A- PAC2 familyEM----- Uncharacterized conserved protein H4 (DUF2046)EM----- DDRGK domainEMF---- Arb2 domainEM----- Uncharacterised conserved proteinEMF---- Spinocerebellar ataxia type 10 protein domainEM----- Coiled-coil domain-containing protein (DUF2037)EMFP--- Exocyst complex component Sec3EM----- Uncharacterized conserved proteinEM----- WD-repeat regionEMF---- Fms-interacting proteinEM----- Predicted membrane protein (DUF2053)EMF---- Peptidase M76 familyEMF---- Apolipoprotein OEMF---- Topoisomerase II-associated protein PAT1EM----- Transmembrane protein 188EM----- Transmembrane protein 26EM----- Meckelin (Transmembrane protein 67)EMF---- Caffeine-induced death protein 2EM----- Keratinocyte-associated protein 2EM----- Mitochondrial ribosomal protein L55EM----- Osteopetrosis-associated transmembrane protein 1 precursorEM----- Guanylyl cyclaseEMF---- Uncharacterized conserved protein (DUF2349)EM----- NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunitEM----- NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunitEMF---- Vacuolar import and degradation proteinE-F---- Mitochondrial ribosomal protein L31EMF---- Prp31 C terminal domainEM----- Cytochrome B561, N terminalEM-P--- Golgin subfamily A member 5EM----- Transmembrane protein 55AEM----- Uncharacterized coiled-coil protein (DUF2353)EM----- HyccinEMF---- Oxidoreductase-like protein, N-terminalE-F---- Ubiquitin 3 binding protein But2EMF---- Anticodon-binding domainEMF---- Transport protein Avl9E-F---- Autophagy-related protein 31E-F---- Ubiquinol-cytochrome-c reductase complex subunit (QCR10)EMF---- N-acetyltransferase B complex (NatB) non catalytic subunitE-F---- DNA damage checkpoint proteinEM----- Predicted membrane proteinEMF---- Integral membrane protein S linking to the trans Golgi networkE-F---- Preprotein translocase subunit Sec66

Uncharacterized conserved protein (DUF2346)EMF---- Uncharacterized conserved protein (DUF2347)EMF---- Nucleolar protein 12 (25kDa)EM----- Cyclin-dependent kinase 2-associated proteinEMF---- Uncharacterized conserved protein (DUF2348)EM----- Small nuclear RNA activating complex (SNAPc), subunit SNAP43EMF---- Mitochondrial ribosomal protein L27EMF---- Defects in morphology protein 1, mitochondrial precursor

Sheet1

EMF---- Essential protein Yae1, N terminalEMF---- Mitochondrial ribosomal protein L28EM----- Coiled-coil domain-containing protein 56EMF---- Uncharacterized conserved protein (DUF2351)EM----- XK-related proteinEMF---- RNA polymerase II transcription elongation factorEM----- Uncharacterized conserved protein (DUF2352)-----A- Predicted ATPase of the ABC class----B-- ABC-type cobalt transport system, permease component----B-- Predicted AAA-ATPase

ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunitEM--B-- ABC-type uncharacterized transport system

Domain of unknown function (DUF2357)ArsR transcriptional regulator

E-F-B-- Biotin-protein ligase, N terminal-----A- Beta propeller domain----BA- CRISPR associated protein Cas2----B-- Chromate resistance exported protein----B-- Uncharacterized protein conserved in bacteria (DUF2057)----B-- Uncharacterized protein conserved in bacteria (DUF2058)

Uncharacterized protein conserved in bacteria (DUF2059)Predicted membrane protein (DUF2061)Uncharacterized protein conserved in bacteria (DUF2062)

----B-- Uncharacterized protein conserved in bacteria (DUF2063)Uncharacterized protein conserved in bacteria (DUF2064)

----B-- Uncharacterized protein conserved in bacteria (DUF2065)-----A- Uncharacterized protein conserved in archaea (DUF2067)

Predicted membrane protein (DUF2069)Predicted membrane protein (DUF2070)Zn-ribbon containing protein (DUF2072)Predicted permease (DUF2074)

EMF---- Uncharacterized conserved protein (DUF2075)----B-- Uncharacterized protein conserved in bacteria (DUF2076)

Uncharacterized protein conserved in bacteria (DUF2077)Predicted membrane protein (DUF2078)Predicted membrane protein (DUF2079)

-----A- Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)Predicted transcriptional regulator (DUF2083)

-----A- Predicted membrane protein (DUF2085)----B-- Uncharacterized protein conserved in bacteria (DUF2086)

Uncharacterized protein conserved in bacteria (DUF2087)Uncharacterized conserved protein (DUF2088)Protein of unknown function(DUF2089)Uncharacterized protein conserved in bacteria (DUF2094)

-----A- Uncharacterized protein conserved in archaea (DUF2095)-----A- Uncharacterized protein conserved in archaea (DUF2096)-----A- Uncharacterized protein conserved in archaea (DUF2098)-----A- Uncharacterized protein conserved in archaea (DUF2099)-----A- Uncharacterized protein conserved in archaea (DUF2100)

Predicted membrane protein (DUF2101)-----A- Uncharacterized protein conserved in archaea (DUF2102)-----A- Predicted membrane protein (DUF2107)-----A- Predicted membrane protein (DUF2108)

Uncharacterized protein conserved in archaea (DUF2110)-----A- Uncharacterized protein conserved in archaea (DUF2112)-----A- Uncharacterized protein conserved in archaea (DUF2113)-----A- Uncharacterized protein conserved in archaea (DUF2115)

Sheet1

Uncharacterized protein containing a Zn-ribbon (DUF2116)-----A- Uncharacterized protein conserved in archaea (DUF2118)-----A- Uncharacterized protein conserved in archaea (DUF2119)-----A- Uncharacterized protein conserved in archaea (DUF2120)-----A- Uncharacterized protein conserved in archaea (DUF2121)-----A- RecB-family nuclease (DUF2122)-----A- Uncharacterized protein conserved in archaea (DUF2124)

Putative amidoligase enzyme (DUF2126)----B-- Predicted membrane protein (DUF2127)----B-- Uncharacterized protein conserved in bacteria (DUF2128)----B-- Uncharacterized protein conserved in bacteria (DUF2130)

Uncharacterized protein conserved in bacteria (DUF2131)Uncharacterized conserved protein (DUF2132)

----B-- Uncharacterized protein conserved in bacteria (DUF2136)Uncharacterized protein conserved in archaea (DUF2139)

----B-- Uncharacterized protein conserved in bacteria (DUF2140)Uncharacterized protein conserved in bacteria (DUF2141)Predicted membrane protein (DUF2142)Uncharacterized protein conserved in bacteria (DUF2145)Uncharacterized protein conserved in bacteria (DUF2147)Uncharacterized conserved protein (DUF2149)Uncharacterized protein conserved in archaea (DUF2150)Uncharacterized protein conserved in archaea (DUF2153)

----B-- Predicted membrane protein (DUF2154)----B-- Uncharacterized protein conserved in bacteria (DUF2155)----B-- Uncharacterized conserved protein (DUF2156)

Predicted membrane protein (DUF2157)----B-- Uncharacterized small protein (DUF2158)----B-- Predicted secreted (periplasmic) protein (DUF2159)

Predicted small integral membrane protein (DUF2160)Uncharacterized conserved protein (DUF2161)Predicted transporter (DUF2162)Uncharacterized conserved protein (DUF2164)Predicted small integral membrane protein (DUF2165)Protein of unknown function (DUF2167)

----B-- Uncharacterized protein conserved in bacteria (DUF2168)Uncharacterized protein conserved in bacteria (DUF2169)Uncharacterized protein conserved in bacteria (DUF2171)Domain of unknown function (DUF2172)Uncharacterized protein conserved in archaea (DUF2175)

-----A- Predicted membrane protein (DUF2178)Uncharacterized protein conserved in archaea (DUF2180)Predicted metal-binding integral membrane protein (DUF2182)

E-F---- Uncharacterized conserved protein (DUF2183)Protein of unknown function (DUF2185)

----B-- Uncharacterized protein conserved in bacteria (DUF2187)----B-- Uncharacterized protein conserved in bacteria (DUF2188)----B-- Predicted integral membrane protein (DUF2189)----B-- Uncharacterized protein conserved in bacteria (DUF2191)

Uncharacterized protein conserved in archaea (DUF2192)Uncharacterized protein conserved in archaea (DUF2193)Uncharacterized protein conserved in bacteria (DUF2194)

----B-- Uncharacterized conserved protein (DUF2196)----B-- Uncharacterized protein conserved in bacteria (DUF2197)----B-- Uncharacterized protein conserved in bacteria (DUF2198)

Uncharacterized protein conserved in bacteria (DUF2200)----B-- Predicted metallopeptidase (DUF2201)

Sheet1

-----A- Uncharacterized protein domain (DUF2202)Uncharacterized conserved protein (DUF2203)Conserved Archaeal protein (DUF2204)

----BA- Predicted membrane protein (DUF2207)Predicted membrane protein (DUF2208)

-----A- Uncharacterized protein conserved in archaea (DUF2209)----B-- Uncharacterized protein conserved in bacteria (DUF2133)

Predicted membrane protein (DUF2214)Uncharacterized protein conserved in bacteria (DUF2218)Uncharacterized protein conserved in bacteria C-term(DUF2220)

----B-- Uncharacterized signal transduction histidine kinase domain (DUF2222)----B-V Uncharacterized protein conserved in bacteria (DUF2225)----B-- Uncharacterized metal-binding protein (DUF2227)

CoA enzyme activase uncharacterised domain (DUF2229)Predicted membrane protein (DUF2231)

----B-- Predicted membrane protein (DUF2232)EM--B-- Predicted periplasmic protein (DUF2233)E-F---- Uncharacterized conserved protein (DUF2235)----B-- Predicted membrane protein (DUF2238)

Uncharacterized protein conserved in bacteria (DUF2239)Uncharacterized protein conserved in archaea (DUF2240)Integral membrane protein (DUF2244)Uncharacterized protein conserved in bacteria (DUF2247)Uncharacterized conserved protein (DUF2249)

-----A- Uncharacterized protein conserved in archaea (DUF2250)----B-- Uncharacterized protein conserved in bacteria (DUF2251)

Uncharacterized protein conserved in bacteria (DUF2252)----B-- Predicted membrane protein (DUF2254)

Uncharacterized protein conserved in bacteria (DUF2256)Uncharacterized protein conserved in bacteria (DUF2257)Uncharacterized protein conserved in archaea (DUF2258)Predicted secreted protein (DUF2259)

E-F-B-- Uncharacterized conserved protein (DUF2260)EMF---- Vitamin-D-receptor interacting Mediator subunit 17t

Predicted aminopeptidase (DUF2265)Uncharacterized conserved protein (DUF2267)

----B-- Predicted Zn-dependent protease (DUF2268)Predicted integral membrane protein (DUF2269)Predicted integral membrane protein (DUF2270)Predicted periplasmic protein (DUF2271)Small integral membrane protein (DUF2273)

E-F---- Phosphate transporter (Pho88)EMF---- Autophagy-related protein 13EM----- Q-cell neuroblast polarisation----BA- Uncharacterized protein conserved in bacteria (DUF2179)EM----- Putative carnitine deficiency-associated proteinEM----- Mitochondrial 28S ribosomal protein S27

Protein of unknown function (DUF2274)Uncharacterized conserved protein (DUF2277)

----B-- Uncharacterized conserved protein (DUF2278)----B-- Predicted periplasmic lipoprotein (DUF2279)EM----- Retinal tissue protein

Uncharacterized conserved protein (DUF2280)EM----- Biogenesis of lysosome-related organelles complex-1 subunit 2

Protein of unknown function (DUF2281)----BA- Protein of unknown function (DUF2283)

Predicted metal-binding protein (DUF2284)

Sheet1

Uncharacterized protein conserved in archaea (DUF2286)Protein of unknown function (DUF2288)Uncharacterized conserved protein (DUF2293)

----B-- Uncharacterized conserved protein (DUF2294)EMFP--- Predicted integral membrane metal-binding protein (DUF2296)

Uncharacterized conserved protein (DUF2299)----B-- Predicted secreted protein (DUF2300)-----A- Uncharacterized conserved protein (DUF2304)

Predicted membrane protein (DUF2306)Predicted domain in sensory proteins (DUF2308)Uncharacterized protein conserved in bacteria (DUF2309)

----B-- Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)----B-- Uncharacterized protein conserved in bacteria (DUF2312)

Uncharacterized conserved protein (DUF2285)EMFP--- COP9 signalosome, subunit CSN8----B-V Uncharacterized protein conserved in bacteria (DUF2313)

Uncharacterized protein conserved in bacteria (DUF2316)----B-- Uncharacterized protein conserved in bacteria (DUF2317)

Predicted membrane protein (DUF2318)Predicted membrane protein (DUF2319)Uncharacterized protein conserved in bacteria (DUF2321)Uncharacterized protein conserved in bacteria (DUF2322)

----B-- Predicted membrane protein (DUF2324)Uncharacterized protein conserved in bacteria (DUF2325)

----B-- Uncharacterized protein conserved in bacteria (DUF2326)Uncharacterized protein conserved in bacteria (DUF2330)Uncharacterized protein conserved in bacteria (DUF2331)Uncharacterized protein conserved in bacteria (DUF2333)

----BA- Uncharacterized protein conserved in bacteria (DUF2334)----B-- Predicted membrane protein (DUF2335)

Uncharacterized protein conserved in bacteria (DUF2336)----B-- Anti-sigma-K factor rskA

Predicted membrane protein (DUF2339)-----A- Domain of unknown function (DUF2341)

Uncharacterised conserved protein (DUF2342)E-F---- Di-sulfide bridge nucleocytoplasmic transport domain

Uncharacterized protein conserved in bacteria (DUF2344)Uncharacterized protein conserved in bacteria (DUF2345)Endonuclease related to archaeal Holliday junction resolvasePredicted 3'-5' exonuclease related to the exonuclease domain of PolB

----B-V Mu-like prophage FluMu protein gp41Membrane domain of glycerophosphoryl diester phosphodiesterasePredicted glycosyltransferase involved in capsule biosynthesis

----B-- 5-bromo-4-chloroindolyl phosphate hydrolysis protein----B-- Predicted histidine kinase sensor domain----B-- Protein required for attachment to host cells

Predicted metal-dependent hydrolase----B-- Predicted methyltransferase regulatory domain-----A- Archaeal phosphomethylpyrimidine kinase----B-V Mu-like prophage protein Com----B-V Mu-like prophage major head subunit gpT-----A- NADH dehydrogenase I, subunit N related protein-----A- Uncharacterized protein, homolog of nitrogen regulatory protein PII----BAV Predicted nucleotidyltransferase

OpgC protein-----A- Predicted nucleotide-binding protein, containing PIN domain----B-- 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein

Sheet1

-----A- Predicted RNA-binding protein----B-- Replication initiator protein A----B-- Rod binding protein

Site-specific recombinase----B-- Predicted nucleotide-binding protein containing TIR-like domain----B-- Tellurium resistance protein

Putative bacterial virulence factor----B-- Predicted membrane protein essB----B-- Single-strand DNA-specific exonuclease, C terminal domainE------ PhoPQ-activated pathogenicity-related protein----BA- 2,3-bisphosphoglycerate-independent phosphoglycerate mutase----B-- Bacterial virulence factor haemolysin----B-V Phage-related minor tail proteinEM----- Zinc finger-containing protein EM----- Growth arrest and DNA-damage-inducible proteins-interacting protein 1EM----- Schwannomin-interacting protein 1EM----- Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5E--PBA- Ribonuclease E/G familyEM----- Uncharacterised conserved protein (DUF2359)EM----- Predicted coiled-coil domain-containing protein (DUF2360)E-F---- Uncharacterised conserved protein (DUF2361)EM----- Uncharacterized conserved protein (DUF2362)EM----- Uncharacterized conserved protein (DUF2363)EMF---- Subunit 17 of Mediator complexEM----- Uncharacterized conserved protein (DUF2365)EM----- Tumour suppressor proteinEMF---- Kinase phosphorylation proteinEM----- Predicted membrane proteinEM----- Putative mitochondrial precursor proteinEM----- G8 domainEMF---- Transcription factor e(y)2EM----- Uncharacterized conserved protein (DUF2367)EM----- Guanine nucleotide exchange factor synembrynEM----- Uncharacterised conserved protein (DUF2368)EM----- Uncharacterised conserved proteinEM----- Nuclear pore componentEM----- Learning-associated proteinEM----- Cysteine-rich domainEM----- Uncharacterised conserved protein (DUF2366)EM----- Det1 complexing ubiquitin ligaseE-F---- Uncharacterised conserved protein (DUF2343)EM----- RIM-binding protein of the cytomatrix active zoneEMF---- M-phase phosphoprotein 6EMF---- Protein of unknown function (DUF2370)EM----- Uncharacterised conserved protein (DUF2371)EM----- Uncharacterised conserved protein (DUF2372)EM----- Uncharacterised conserved protein (DUF2369)EMF---- Uncharacterised conserved protein (DUF2373)EMF---- GPI-GlcNAc transferase complex, PIG-H componentEM----- ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) EM----- Uncharacterized conserved protein (DUF2358)EM----- Chaperone for wingless signalling and trafficking of LDL receptorEM----- Predicted coiled-coil protein (DUF2355)EM----- N-terminal domain of NEFA-interacting nuclear protein NIP30EM----- Organic solute transport protein 1EM----- Conserved protein (DUF2356)EM----- Putative transmembrane protein 170

Sheet1

EM----- Golgi complex component 7 (COG7)EM----- Rhodopsin-like GPCR transmembrane domainEMF---- Telomere length regulation proteinEM----- DNA-binding nuclear phosphoprotein p8EMFP--- N-terminal domain of CBF1 interacting co-repressor CIREMF---- Histone acetyltransferases subunit 3EM----- Alpha and gamma adaptin binding protein p34EM----- NADH:ubiquinone oxidoreductase, NDUFS5-15kDaEMF---- Cytochrome c oxidase assembly protein PET191EM----- Dual oxidase maturation factorEMF---- Predicted coiled-coil domain-containing proteinEM----- Mitochondrial F1F0-ATP synthase, subunit fEM----- Degradation arginine-rich protein for mis-foldingEMF---- Uncharacterized conserved protein (DUF2340)EM----- Mitochondrial 28S ribosomal protein S32EM-P--- Axonemal dynein light chainEM----- Predicted coiled-coil domain-containing proteinEMF---- Mitochondrial ribosomal subunit protein E-F---- RNA polymerase I-specific transcription-initiation factorEMF---- Oligosaccaryltransferase EM----- Uncharacterized conserved protein (DUF2039)EM----- Uncharacterized conserved protein (DUF2054)EM----- Uncharacterized conserved protein (DUF2146)EM----- Cell cycle and development regulatorEM----- Uncharacterized conserved protein (DUF2152)EM----- Uncharacterized conserved protein (DUF2181)EMF---- Predicted coiled-coil protein (DUF2205)EM----- Uncharacterized conserved protein (DUF2215)EM----- Uncharacterized conserved proteins (DUF2216)EM----- Uncharacterised conserved protein (DUF2228)EM----- Uncharacterized conserved protein (DUF2246)EMF---- Uncharacterised conserved protein (DUF2305)EM----- Uncharacterised conserved protein (DUF2315)EMF---- Mediator of RNA polymerase II transcription complex subunit 8EMF---- Uncharacterized conserved protein CG6151-PEM----- Clusterin-associated protein-1EM----- Microtubule-associated protein CRIPTEMF---- Mitochondrial ribosomal death-associated protein 3EMF---- Probable N6-adenine methyltransferaseEM----- E2F-associated phosphoproteinEM----- Protein of unknown function (DUF2465)EM----- Protein of unknown function (DUF2464)EMF---- Uncharacterized conserved proteinEM----- Lipoma HMGIC fusion partner-like proteinEMF---- Microtubule-binding protein MIP-T3EM----- Mitochondrial ribosomal subunitEM----- Mitochondrial 28S ribosomal protein S22EM----- Mitochondrial ribosomal protein MRP-S35EMF---- Reactive mitochondrial oxygen species modulator 1EM----- Myelodysplasia-myeloid leukemia factor 1-interacting proteinEM-P--- NADH-ubiquinone oxidoreductase subunit 10EM-P--- GDP-fucose protein O-fucosyltransferaseEM-P--- Presenilin enhancer-2 subunit of gamma secretaseEM----- Casein kinase substrate phosphoprotein PP28EMF---- Mitotic checkpoint protein PRCC_CtermEM----- PACS-1 cytosolic sorting proteinEMF---- RNA polymerase I-associated factor PAF67

Sheet1

EMF---- Golgin subfamily A member 7/ERF4 familyEM----- Retinoic acid induced 16-like proteinEM----- PHAX RNA-binding domainEMF---- Rogdi leucine zipper containing proteinEM----- Uncharacterized conserved domain (SAYSvFN)EMF---- Inositol phospholipid synthesis protein Scs3pEM-P--- Rdx familyEMF-B-- SprT-like familyEM----- Winged helix Storkhead-box1 domainEM----- Uncharacterized conserved protein (DUF2217)EM----- Hereditary spastic paraplegia protein strumpellinEM----- Predicted transmembrane and coiled-coil 2 proteinEM----- Predicted transmembrane protein 161ABEM----- Transmembrane Fragile-X-F protein EMF---- Membrane magnesium transporterEM----- Putative transmembrane proteinEM----- Putative transmembrane protein precursorEMF---- Pre-rRNA-processing protein TSR2EM----- Parkin co-regulated proteinEM-PB-- Peptidase C65 OtubainEMF---- Zinc-finger domainEMF---- Frag1/DRAM/Sfk1 familyEM----- Mediator of RNA pol II transcription subunit 19 EM----- Latarcin precursorEMF---- Mediator complex protein E-F---- Putative stress-responsive nuclear envelope proteinE-F-B-- 3-carboxy-cis,cis-muconate lactonizing enzymeEM----- Zinc-finger (CX5CX6HX5H) motif

Luciferase helical bundle domainEMFP--- Protein of unknown function (DUF2392)E-F---- Glycine-rich protein domain (DUF2403)EMF---- SAFF domain EM----- Serpentine type 7TM GPCR receptor class ab chemoreceptorE-F---- Domain of unknown function (DUF2405)EMF---- Putative methyltransferaseE-F---- Uncharacterised protein (DUF2406)EMF---- Putative integral membrane protein conserved region (DUF2404)EMF---- Putative mitochondrial outer membrane proteinE-F---- Putative membrane protein (DUF2407)E-F---- Protein of unknown function (DUF2408)EMF---- Domain of unknown function (DUF2411)E-F---- RNA pol II promoter Fmp27 protein domainE-F---- Hypothetical protein (DUF2410)EMF---- Protein of unknown function (DUF2414)E-F---- Protein of unknown function (DUF2413)E-F---- Increased loss of mitochondrial DNA protein 1EMF---- Conserved mid region of cactinE-F---- Uncharacterised protein domain (DUF2415)E-F---- Protein of unknown function (DUF2416)

Serpentine type 7TM GPCR chemoreceptor Srbc EM----- Serpentine type 7TM GPCR chemoreceptor SrdEM----- Serpentine type 7TM GPCR chemoreceptor SrhEM----- Serpentine type 7TM GPCR chemoreceptor Srj

Serpentine type 7TM GPCR chemoreceptor SrsxEM----- Serpentine type 7TM GPCR chemoreceptor SrtEM----- Serpentine type 7TM GPCR chemoreceptor SrvEM----- Serpentine type 7TM GPCR chemoreceptor Srw

Sheet1

Serpentine type 7TM GPCR chemoreceptor SrzSerpentine type 7TM GPCR chemoreceptor StrSerpentine type 7TM GPCR chemoreceptor Sri

EM----- Serpentine type 7TM GPCR chemoreceptor SrxE-F---- Region of unknown function (DUF2417)E-F---- Putative Sin3 binding proteinE-F---- Protein of unknown function (DUF2418)E-F---- Protein of unknown function (DUF2421)

Putative nucleotidyltransferase substrate binding domainE-F---- Protein of unknown function (DUF2420)E-F---- Protein of unknown function (DUF2422)E-F---- Protein of unknown function (DUF2423)E-F---- Velum formation proteinE-F---- Protein of unknown function (DUF2424)E-F---- Developmentally Regulated MAPK Interacting ProteinEMF---- Protein of unknown function (DUF2419)EMF---- Mitochondrial protein from FMP27EMF---- Cohesin loading factorE-F---- Conidiation protein 6EMF---- RNA pol II promoter Fmp27 protein domainE-F---- Domain of unknown function (DUF2427)EMF---- WW-domain ligand proteinEMF---- Putative death-receptor fusion protein (DUF2428)EMF---- Golgi-body localisation protein domainE-F---- Protein of unknown function (DUF2430)EMFP--- Domain of unknown function (DUF2431)EMF---- Domain of Kin17 curved DNA-binding proteinEMF---- Oestrogen-responsive protein Fam102A-BE-F---- RNA pol II promoter Fmp27 protein domainE-F---- Protein of unknown function (DUF2433)E-F-BA- Cytidylyltransferase C-terminal domain (DUF2432)EM----- Protein of unknown function (DUF2435)

Putative capsular polysaccharide synthesis protein----B-- Domain of unknown function (DUF2436)EMF---- Vacuolar sorting protein 39 domain 1EMF---- Vacuolar sorting protein 39 domain 2----B-- Putative cell-wall binding lipoproteinE-F-BA- Small subunit of acetolactate synthase

Domain of unknown function (DUF2437)Bacterial membrane-spanning protein N-terminus

E-F---- Est1 DNA/RNA binding domainEMF---- Telomerase activating protein Est1E-F---- GRIP-related Arf-binding domain EMF---- Double-strand recombination repair protein EMF---- Autophagy-related protein 11E-F---- Putative RRM domain

Virulence protein nec1EMFP--- Autophagocytosis associated protein C-terminalEMF---- Protein of unknown function (DUF2439)EMF---- Centromere protein Scm3E--PB-- RNA polymerase beta subunit external 1 domain----B-- EAL-domain associated signalling protein domain------V Bacteriophage coat protein B EMF---- RNA polymerase II elongation factor ELL EMF---V Fingers domain of DNA polymerase lambdaEMF---- Golgi transport complex subunit 5EM-P--- Trimeric coiled-coil oligomerisation domain of matrilin

Sheet1

EMFP--- Histone acetyl transferase HAT1 N-terminusE-F---- Utp8 familyEMF-B-- GTP-binding protein TrmE N-terminusEMF-BA- Adenylosuccinate lyase C-terminus----B-- Protein of unknown function (DUF2443)----B-- Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal----B-- Virulence activator alpha C-termEM----- Interferon-regulatory factor 3EMF---- Rad4 beta-hairpin domain 1EMF---- Rad4 beta-hairpin domain 2EMF---- Rad4 beta-hairpin domain 3EMF---- Transcription factor TFIID complex subunit 8 C-term EMFP--- Ubiquitin elongating factor coreEM-P--- C2 domain of PTEN tumour-suppressor protein----B-- DnaB-helicase binding domain of primase----B-- Disulfide bond isomerase protein N-terminus----B-- Type IV secretion-system coupling protein DNA-binding domain----B-- Sirohaem synthase dimerisation regionEMFPBA- Fumarase C C-terminus

Transcription-initiator DNA-binding domain IBDEMFPBA- C-terminal domain of 1-Cys peroxiredoxin----BA- Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase BEMF---- TFIIIC subunitEM----- 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus E-F---- Monopolin complex subunit LRS4----B-- Bacterial AMP nucleoside phosphorylase N-terminus EMF---V Clamp-loader complex subunit E C-terminus----B-- C-terminus of bacterial fibrinogen-binding adhesinEM----- Recombination-activating protein 1 zinc-finger domainE-F---- RAM signalling pathway proteinE-F---- Nuclear pore RNA shuttling protein Mtr2EMFPB-- C-terminal, D2-small domain, of ClpB protein ----BA- Bacterial phospho-glucose isomerase C-terminal regionE-F---- Beta-galactosidase, domain 2EMF---- Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase----BA- Bacterial lipoate protein ligase C-terminus

Cyclo-malto-dextrinase C-terminal domain----B-- Bacteriocin class II with double-glycine leader peptideEMF---- Urb2/Npa2 familyEM-PBA- FIST C domainE-F---- RNA12 proteinEMF---- Nbl1 / Borealin N terminalE-F---- Protein of unknown function (DUF2456)E-F---- Protein of unknown function (DUF2457)EMF---- Exosome component EXOSC1/CSL4E-F---- 20S proteasome chaperoneE-F---- Telomere regulation protein Stn1E-F---- TORC1 subunit TCO89EMF---- Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)E-F---- Protein of unknown function (DUF2458)E-F---- Bin/amphiphysin/Rvs domain for vesicular traffickingEM----- WASP-binding domain of Sorting nexin proteinEM----- Cholesterol-capturing domainEM--B-- Valyl tRNA synthetase tRNA binding arm

Peptidase S46----B-- Peptidase M30EM----- Peptidase S68

Sheet1

E---B-- Peptidase M66----B-- Peptidase U49E-F---- Saccharopepsin inhibitor I34E-F---- Peptidase inhibitor clitocypinEM----- Carboxypeptidase inhibitor I68EM----- Protein kinase A anchor protein nuclear localisation signalEM----- PKA-RI-RII subunit binding domain of A-kinase anchor proteinEM----- Anaphase-promoting complex APC subunitEM----- eIF2-alpha phosphatase phosphorylation constitutive repressorEM----- Leucine-rich repeats of kinetochore protein Cenp-F/LEK1EM----- Protein of unknown function C-terminus (DUF2451)EM----- Protein of unknown function N-terminal domain (DUF2450) EM----- Protein of unknown function C-terminus (DUF2448) EM----- Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4EEM----- Fragile site-associated protein C-terminusEM----- Beta-1 integrin binding proteinEM----- Cenp-F N-terminal domainEM----- Tumour-suppressor protein CtIP N-terminal domainEMF---- Histone acetylation protein 2EMF---- Mitochondrial ribosomal protein S23EM----- Phosphoinositide 3-kinase gamma adapter protein p101 subunitEMF---- Nucleoporin subcomplex protein binding to Pom34EM----V Phosphatase-1 catalytic subunit binding regionEM----- Ret finger protein-like 3 antisenseEM----- NLS-binding and DNA-binding and dimerisation domains of Nrf1EM----- Nrf1 activator activation site binding domainEM----- Rough deal protein C-terminal regionEMF---- Serine-threonine protein kinase 19EMF---- Pericentrin-AKAP-450 domain of centrosomal targeting proteinEMFP--- SNARE-complex protein Syntaxin-18 N-terminus EM----- Zinc-finger domain of monoamine-oxidase A repressor R1EM-P--- Intra-flagellar transport protein 57 EM----- Peroxisomal membrane protein 24EM----- Nuclear RNA-splicing-associated proteinEMF---- Ribosomal subunit 39SE--PB-- Peptidase S26 E-F-B-- Esterase PHB depolymeraseEM----- Protein of unknown function (DUF2452)EM----- NMDA receptor-regulated gene protein 2EM----- PDZ domain of MCC-2 bdg protein for Usher syndromeEM----- Protein of unknown function (DUF2453)EMF---- Proteasome non-ATPase 26S subunitEMFPBA- Galactokinase galactose-binding signatureEMF---- Phosphatidylinositol-glycan biosynthesis class S proteinEM----- Cell division cycle-associated protein 8 EMF---- Enhancer of polycomb-likeEM----- Pro-apoptotic Bcl-2 protein, BADEM----- beta-amyloid precursor protein C-terminusEMF---- SHNi-TPREM----- Electron transfer DM13----B-- TAT (twin-arginine translocation) pathway signal sequenceEM----V Kua-ubiquitin conjugating enzyme hybrid localisation domainEMFP--- Protein of unknown function (DUF2454)EM----- RII binding domainEM----V BEN domainEM----- Nuclear factor I protein pre-N-terminusEM----- Engrailed homeobox C-terminal signature domain

Sheet1

EM----- NADH-ubiquinone reductase complex 1 MLRQ subunit----B-- Pyrrolo-quinoline quinone coenzyme N-terminusEMF-B-- SLBB domain

Plant specific N-all beta domainE--P--- Plant zinc cluster domainEM----- Connector enhancer of kinase suppressor of ras----B-- Pyrrolo-quinoline quinone coenzyme C-terminusEMF---- ATP-utilising chromatin assembly and remodelling N-terminalEMF---- Munc13 (mammalian uncoordinated) homology domainEM----- Nuclear envelope localisation domainEM----- Vitelline membrane cysteine-rich region

ORF6N domain----B-V T5orf172 domainEM----- Alcohol dehydrogenase transcription factor Myb/SANT-like

P63C domain----B-V P22AR C-terminal domain----B-V ORF11CD3 domainEMFP--- MULE transposase domain

ORF6C domain------V MSV199 domainEMFP--- Cullin protein neddylation domainEM----V Mitochondrial 18 KDa protein (MTP18) EMF--A- Plug domain of Sec61pEM----- Uncharacterised protein family UPF0565EM----- Calmodulin-binding domain C0 of NMDA receptor NR1 subunitE------ Sialic-acid binding micronemal adhesive repeatEM----- N-methyl D-aspartate receptor 2B3 C-terminusE-F---- RNA-recognition motifEMF---- Outer mitochondrial membrane transport complex proteinEM--B-- Alpha-macro-globulin thiol-ester bond-forming regionEM--B-- Uncharacterised protein family UPF0547EM----- Uncharacterised protein family UPF0556EM----- Uncharacterised protein family UPF0561EMF-B-- Iron-sulfur binding domain of endonuclease IIIEM----- Uncharacterised protein family UPF0560EM----- Rapsyn N-terminal myristoylation and linker regionEM----- Gap junction protein N-terminal regionEM----- Synapsin N-terminalEM----- Gap junction channel protein cysteine-rich domainEM----- Involucrin of squamous epithelia N-terminusEMFP-A- Proteasome subunit A N-terminal signatureEMFP--- Ubiquitin-activating enzyme active site EMF---- Eukaryotic elongation factor 1 beta central acidic regionEMFPB-- NADH-ubiquinone oxidoreductase-G iron-sulfur binding regionEMF-B-- NADH-ubiquinone oxidoreductase-F iron-sulfur binding regionEMF-B-- Pyridoxine 5'-phosphate oxidase C-terminal dimerisation regionEM----- Secreted protein acidic and rich in cysteine Ca binding region

AIPR proteinZ1 domain

EM----- Uncharacterised protein family UPF0564EMF---- U6-snRNA interacting domain of PrP8EMF---- U5-snRNA binding site 2 of PrP8EMF---- RNA recognition motif of the spliceosomal PrP8EM----- PDZ-associated domain of NMDA receptorsEM----- LITAF-like zinc ribbon domainEMFP--- 26S proteasome subunit RPN7E--PB-- Polyketide cyclase / dehydrase and lipid transport

Sheet1

EM----- Homer-binding domain of metabotropic glutamate receptor EMF---- Ran binding protein in the microtubule-organising centreEM----- Polyubiquitination (PEST) N-terminal domain of MAGUKEMF-BA- ParA/MinD ATPase like----B-- Thin aggregative fimbriae synthesis protein----B-- Spore coat protein ZEM----- Ligated ion channel L-glutamate- and glycine-binding site----B-- Protein of unknown function (DUF2470)----B-V Phage tail tube protein----B-- Phosphoribosyl-dephospho-CoA transferase MdcG

F420H2 dehydrogenase subunit FpoO -----A- Energy-converting hydrogenase B subunit P (EhbP)

Plasmid conjugative transfer protein PilIPlasmid conjugative transfer entry exclusion protein TraSConjugative transposon protein TraO

----B-- Outer spore coat protein E (CotE)EM----- Protein of unknown function (DUF2475)EM----- Protein of unknown function (DUF2477)

He_PIG associated, NEW1 domain of bacterial glycohydrolase----B-- NPCBM-associated, NEW3 domain of alpha-galactosidase----B-- Fe2+ transport protein----B-- DisA bacterial checkpoint controller linker region ----B-- Hemin uptake protein hemPEMF---- Oxoglutarate and iron-dependent oxygenase degradation C-termE-F---- Spindle body associated protein C-terminus EM----- Uncharacterised protein family UPF0546------V mRNA capping enzyme N-terminal, ATPase and guanylyltransferaseE-F---- Mitochondrial import receptor subunit or translocase----B-- Photosystem P840 reaction-centre cytochrome c-551EMF---- Misato Segment II myosin-like domainE-F---- Carbohydrate binding----B-- Sporulation and spore germination----B-- Lipoprotein LpqB beta-propeller domain----B-- Protein of unknown function (DUF2478)EMF---- Putative zinc-finger domain

Domain of unknown function (DUF2479)Protein of unknown function (DUF2480)Protein of unknown function (DUF2481) Hypothetical protein of unknown function (DUF2482)

----B-- Photosystem P840 reaction centre protein PscDProtein of unknown function (DUF2484)

E------ Trypanosome variant surface glycoprotein C-terminal domainEM----- Iron-containing outer mitochondrial membrane protein N-terminus ----B-- Firmicute eSAT-6 protein secretion system EssA----B-- Ethanolamine utilisation - propanediol utilisation----B-- Virulence factor EsxBE--PB-- Cyanobacterial and plastid NDH-1 subunit M------V Phage protein Gp9

Protein of unknown function (DUF2486)----B-- Phage terminase small subunit

Protein gp23 (Bacteriophage A118)----B-- Nickel uptake substrate-specific transmembrane region ----B-- Toxin co-regulated pilus biosynthesis protein Q----B-- Protein of unknown function (DUF2487)E---B-- Protein of unknown function (DUF2488)----B-- Protein of unknown function (DUF2489)----B-- Spore germination protein gerPA/gerPF

Sheet1

----B-- Protein of unknown function (DUF2492)----B-- Protein of unknown function (DUF2491)E-F---- RNA polymerase I specific transcription initiation factorE-F---- Chaperone for protein-folding within the ER, fungalEM----- Hermes transposase DNA-binding domain E-F-B-- Stress-induced bacterial acidophilic repeat motif------V Protein of unknown function (DUF2493)----B-- Bacterial inner membrane protein----B-- Protein of unknown function (DUF2496)EM----- Myticin pre-proprotein from the mussel----B-- Protein of unknown function (DUF2497) ----B-- Protein of unknown function (DUF2500)----B-- Protein of unknown function (DUF2501)----BA- Protein of unknown function (DUF2507)----B-- Molybdenum cofactor biosynthesis protein F----B-- Protein of unknown function (DUF2508)E--P--- Chloroplast protein precursor Ycf15 putative----B-- Aminoglycoside-2''-adenylyltransferase----B-- PhoP regulatory network protein YrbL

Protein of unknown function (DUF2510)----B-- Protein of unknown function (DUF2511)----B-- Protein of unknown function (DUF2512)----B-- Hypothetical protein (DUF2513)E-F---- NAD-specific glutamate dehydrogenase----B-- Protein of unknown function (DUF2509)

Late embryogenesis abundant protein 18------V Endoribonuclease RegB T4-bacteriophage encodedE---B-- NADH dehydrogenase transmembrane subunit------V Occlusion-derived virus envelope protein ODV-E18----B-- Late competence development protein ComFB----B-V Protein of unknown function (DUF2514)----B-- Putative bacterial sensory transduction regulator----B-V Replication regulatory protein RepB----B-- Protein of unknown function (DUF2516)E---B-- Protein of function (DUF2518)

Rossmann-like domainDomain of unknown function (DUF2520)

----B-- Cell division activator CedA----B-- Protein of unknown function (DUF2521)

Thrombin inhibitor from mosquito----B-- Protein of unknown function (DUF2524)----B-- Protein of unknown function (DUF2525)----B-- Protein of unknown function (DUF2526) ----B-- Protein of unknown function (DUF2627) ----B-- Spore germination protein GerPC----B-- Probable lipoprotein LpqN----B-- Protein of unknown function (DUF2550)----B-- Protein of unknown function (DUF2529)----B-- General secretion pathway protein MEMF---- Mediator of RNA polymerase II transcription subunit 1----B-- Protein of unknown function (DUF2530)------V Phage holin family 6----B-- Protein of unknown function (DUF2522)----B-- Protein of unknown function (DUF2531)----B-- Protein of unknown function (DUF2534)----B-- Protein of unknown function (DUF2536)----B-- Protein of unknown function (DUF2535)

Sheet1

----B-- Protein of unknown function (DUF2533) ----B-- Protein of unknown function (DUF2566)----B-- Protein of unknown function (DUF2569)----B-- Protein of unknown function (DUF2585)----B-- Protein of unknown function (DUF2587)------V Protein of unknown function (DUF2590)----B-- Protein of unknown function (DUF2583) ----B-- Inhibitor of sigma-G Gin------V Protein of unknown function (DUF2591)----B-- Protein of unknown function (DUF2593)----B-- Class II flagellar assembly regulator----B-- Protein of unknown function (DUF2594)----B-- Protein of unknown function (DUF2596)-----A- Protein of unknown function (DUF2582)------V Protein of unknown function (DUF2597)----B-- Biofilm regulator BssSE-F---- ATP synthase complex subunit h----B-- Protein of unknown function (DUF2600)----B-- Extracytoplasmic function sigma factor YlaC----B-- Halocarboxylic acid dehydrogenase DehI----B-- Haemolysin XhlAEMF---- 39S ribosomal protein L53/MRP-L53----B-- Protein of unknown function (DUF2602)----B-- Protein of unknown function (DUF2599)----B-- Uncharacterised protein from bacillus cereus group----B-- Protein of unknown function (DUF2603)------V Phage RNA polymerase binding, RpbA----B-- Protein of Unknown function (DUF2604)----B-- Protein of unknown function (DUF2605)EM----- Gloverin-like protein ----B-- Protein of unknown function, DUF2606 ----B-- Protein of unknown function (DUF2607)----B-- Sigma-S stabilisation anti-adaptor protein ----B-- Biofilm development protein YmgB/AriR----B-- Biofilm formation protein (YliH/bssR)----B-V Protein of unknown function (DUF2528) -----A- Protein of unknown function (DUF2540)----B-- Protein of unknown function (DUF2539)----B-- Protein of unknown function (DUF2538) ----B-V Protein of unknown function (DUF2730)----B-- Protein of unknown function (DUF2542) ------V Protein of unknown function (DUF2732)----B-- Protein of unknown function (DUF2532)----B-- Protein of unknown function (DUF2561)------V Protein of unknown function (DUF2733)----B-- Protein of unknown function (DUF2562)

Domain of unknown function (DUF2760)----B-- Protein of unknown function (DUF2547)----B-- Protein of unknown function (DUF2564) ----B-- Protein of unknown function (DUF2543)----B-- Protein of unknown function (DUF2567)----B-- Protein of unknown function (DUF2568)----B-- Protein of unknown function (DUF2580)

Protein of unknown function (DUF2752)-----A- Protein of unknown function (DUF2551) ----B-- Protein of unknown function (DUF2552) ----B-- Protein of unknown function (DUF2570)

Sheet1

----B-- Protein of unknown function (DUF2554)----B-- Protein of unknown function (DUF2572)------V Protein of unknown function (DUF2560)----B-- Protein of unknown function (DUF2573)----B-- Protein of unknown function (DUF2574) ----B-- Protein of unknown function (DUF2575)------V Protein of unknown function (DUF2677)E--P--- Protein of unknown function (DUF2647) ----B-- Protein of unknown function (DUF2644)----B-- Protein of unknown function (DUF2642)E-F---- Protein of unknown function (DUF2578)------V Protein of unknown function (DUF2576)E-F---- Protein of unknown function (DUF2722)----B-- Protein of unknown function (DUF2656)------V Protein of unknown function (DUF2654)----B-- Protein of unknown function (DUF2653)----B-- Protein of unknown function (DUF2652) ----B-- Protein of unknown function (DUF2651) EM----- Protein of unknown function (DUF2650)------V Protein of unknown function (DUF2649)----B-- Protein of unknown function (DUF2648)----B-- Protein of unknown function (DUF2660)------V Protein of unknown function (DUF2661)

Protein of Unknown function (DUF2784)----B-- Protein of unknown function (DUF2662)E-F---- Protein of unknown function (DUF2702)----B-- Protein of unknown function (DUF2663)-----A- Protein of unknown function (DUF2703)------V Protein of unknown function (DUF2704)------V Protein of unknown function (DUF2664)E--P--- Protein of unknown function (DUF2667)-----A- Protein of unknown function (DUF2666) ------V Protein of unknown function (DUF2729)------V Protein of unknown function (DUF2740)EM----- Protein of unknown function (DUF2668)------V Protein of unknown function (DUF2746)----B-- Protein of unknown function (DUF2670)----B-- Protein of unknown function (DUF2669)----B-- Protein of unknown function (DUF2671)----B-- Protein of unknown function (DUF2672)----B-- Protein of unknown function (DUF2674)----B-- Protein of unknown function (DUF2673)----B-- Protein of unknown function (DUF2679)----B-- Protein of unknown function (DUF2681)-----A- Protein of unknown function (DUF2683)----B-- Protein of unknown function (DUF2684)------V Protein of unknown function (DUF2685)------V Protein of unknown function (DUF2719)----B-- Protein of unknown function (DUF2688)------V Protein of unknown function (DUF2724)----B-- Protein of unknown function (DUF2714)----B-- Protein of unknown function (DUF2716)----B-- Protein of unknown function (DUF2743)------V Protein of unknown function (DUF2693)----B-- Protein of unknown function (DUF2691)----B-- Protein of unknown function (DUF2694)----B-- Protein of unknown function (DUF2695)

Sheet1

E-F---- Protein of unknown function (DUF2697)----B-- Protein of unknown function (DUF2749)

Protein of unknown function (DUF2778)------V Protein of unknown function (DUF2682)------V Protein of unknown function (DUF2744)------V Protein of unknown function (DUF2717)EM----- Protein of unknown function (DUF2700)----B-- Protein of unknown function (DUF2706)EM----- Protein of unknown function (DUF2708)------V Protein of unknown function (DUF2718)----B-- Protein of unknown function (DUF2699)----B-- Protein of unknown function (DUF2705)------V Protein of unknown function (DUF2745)

Protein of unknown function (DUF2791)----B-- Protein of unknown function (DUF2711)----B-- Protein of unknown function (DUF2680)------V Protein of unknown function (DUF2800)------V Protein of unknown function (DUF2738)----B-- Protein of unknown function (DUF2810)----B-- Protein of unknown function (DUF2735)


----B-- Protein of unknown function (DUF2634)------V Protein of unknown function (DUF2637)EMF---- Protein of unknown function (DUF2638)----B-- YfdX protein----B-- Protein of unknown function (DUF2631) ----B-- Protein of unknown function (DUF2618)----B-- Protein of unknown function DUF2620------V Protein of unknown function (DUF2632)----B-- Protein of unknown function (DUF2630)----B-- Protein of unknown function DUF2625----B-- Protein of unknown function (DUF2628) ----B-- Protein of unknown function (DUF2776)----B-- Protein of unknown function (DUF2753)----B-- Protein of unknown function (DUF2754)----B-- Protein of unknown function (DUF2755)----B-- Protein of unknown function (DUF2757)----B-- Protein of unknown function (DUF2756)----B-- Protein of unknown function (DUF2758)----B-- Protein of unknown function (DUF2759)----B-V Protein of unknown function (DUF2762)EM----- Protein of unknown function (DUF2763)----B-- Protein of unknown function (DUF2767)----B-- Protein of unknown function (DUF2768)----B-- Protein of unknown function (DUF2771)----B-- Protein of unknown function (DUF2773)

Protein of unknown function (DUF2804)Protein of unknown function (DUF2802)Protein of unknown function (DUF2797)Protein of unknown function (DUF2785)Protein of unknown function (DUF2788)Protein of unknown function (DUF2789)Protein of unknown function (DUF2794)Protein of unknown function (DUF2805)Protein of unknown function (DUF2796)Protein of unknown function (DUF2807)

Sheet1

Protein of unknown function (DUF2808)----B-- Protein of unknown function (DUF2809)------V Protein of unknown function (DUF2815)


----B-- Protein of unknown function (DUF2819)EMFPBA- Beta-Casp domainE-F---- Protein of unknown function (DUF2838)


E-F---- Protein of unknown function (DUF2841)EM----- RFPL defining motif (RDM)


----B-- Spore coat associated protein JA (CotJA)----B-- Protein of unknown function (DUF2846)----B-- Protein of unknown function (DUF2847)

Protein of unknown function (DUF2848)Protein of unknown function (DUF2849)Protein of unknown function (DUF2850)Protein of unknown function (DUF2852)Protein of unknown function (DUF2853)


EM----- Pupal cuticle protein C1----B-- Protein of unknown function (DUF2608)----B-- Protein of unknown function (DUF2610)----B-- Protein of unknown function (DUF2613)E-F---- Protein of unknown function (DUF2611)----B-- Protein of unknown function (DUF2614)

Dispersed gene family protein 1 of Trypanosoma cruzi region 4Glycoprotein GP40 of CryptosporidiumProtein of unknown function (DUF2721)

EM----- Protein of unknown function (DUF2615)EM----- Protein of unknown function (DUF2723)EM----- DAZ associated protein 2 (DAZAP2)------V Nucleocapsid protein N ------V Bacteriophage T holinEM----- Apolipoprotein M (ApoM)----B-- Competence protein J (ComJ)E-F---- Protein of unknown function (DUF2823)------V Protein of unknown function (DUF2824)

Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus ------V Protein of unknown function (DUF2856)------V Plectrovirus spv1-c74 ORF 12 transmembrane protein----B-- Transcriptional repressor of hyc and hyp operons----B-- Salmonella outer protein D

Glycoprotein K1 of Kaposi's sarcoma-associated herpes virus------V Virus envelope protein E26E-F---- Mannosyltransferase putativeE------ Trans-sialidase of Trypanosoma hydrophobic C-terminalE-F---- Glucose signalling factor 2------V Recombination, repair and ssDNA binding protein UvsYEM----- Cortexin of kidney------V Antirestriction protein Ral


Sheet1

Protein of unknown function (DUF2866)----B-- Protein of unknown function (DUF2868)----B-- Protein of unknown function (DUF2869)EM----- Protein of unknown function (DUF2870)

Protein of unknown function (DUF2871)----B-- Protein of unknown function (DUF2872)----B-- Domain of unknown function(DUF2779)----B-- Putative inner membrane protein YbhQ------V Protein of unknown function (DUF2616)EM----- Optomotor-blind protein N-terminal region----B-- Protein of unknown function (DUF2622)------V Protein of unknown function (DUF2890)

Lantibiotic streptin immunity protein----B-- Protein of unknown function (DUF2621)----B-- Conserved membrane protein YqhR------V Protein of unknown function (DUF2881)------V Glycoprotein encoding membrane proteins RL5A and RL6------V Protein of unknown function (DUF2833)EM----- Neuronal protein 3.1 (p311)E-F---- Mitochondrial export protein Som1------V Membrane-associated tegument proteinEM----- Gem-associated protein 7 (Gemin7)----B-- Chlorosome envelope protein C------V Apoptosis regulator M11L like----B-- Protein of unknown function (DUF2884)----B-- Competence protein AEM----- Arthropod cardioacceleratory peptide 2aEM----- Fanconi anemia group F protein (FANCF)------V Baseplate hub distal subunitEM----- Centromere protein M (CENP-M)----B-- Pyocin activator protein PrtN------V Head assembly gene product

Minor capsid----B-- Protein of unknown function (DUF2624)----B-- Protein of unknown function (DUF2627)----B-- Protein of unknown function (DUF2633)----B-- Protein of unknown function (DUF2636)----B-- Inner spore coat protein D------V DNA packaging protein ------V Protein of unknown function (DUF2830)------V Transcriptional regulator DsbA----B-- Protein of unknown function (DUF2892)

Plant viral coat protein nucleocapsid------V Rev protein of equine infectious anaemia virus----B-- F pilus assembly Type-IV secretion system for plasmid transfer----B-- Rap-phr extracellular signalling----B-- Transcriptional regulator protein (SplA)------V Phage stabilisation protein


----B-- Protein of unknown function (DUF2910)Protein of unknown function (DUF2913)Protein of unknown function (DUF2914)Protein of unknown function (DUF2917)

----B-- Protein of unknown function (DUF2919)EM----- Protein of unknown function (DUF2920)----B-- Protein of unknown function (DUF2905)

Sheet1


----B-- Protein of unknown function (DUF2929)Protein of unknown function (DUF2930)Protein of unknown function (DUF2931)Protein of unknown function (DUF2937)Protein of unknown function (DUF2938)Protein of unknown function (DUF2939)Protein of unknown function (DUF2945)Protein of unknown function (DUF2946)Protein of unknown function (DUF2946)Protein of unknown function (DUF2947)Protein of unknown function (DUF2948)Protein of unknown function (DUF2951)

----B-- Protein of unknown function (DUF2953)Protein of unknown function (DUF2955)Protein of unknown function (DUF2956)Protein of unknown function (DUF2958)Protein of unknown function (DUF2959)Protein of unknown function (DUF2970)Protein of unknown function (DUF2961)

EMF---- Protein of unknown function (DUF2962)Protein of unknown function (DUF2964)Protein of unknown function (DUF2963)Protein of unknown function (DUF2967)Protein of unknown function (DUF2968)

----B-- Heat induced stress protein YflT----B-- Polymyxin resistance protein PmrD


----B-- Protein of unknown function (DUF2974)Protein of unknown function (DUF2975)Protein of unknown function (DUF2973)Protein of unknown function (DUF2976)Protein of unknown function (DUF2782)Domain of unknown function (DUF2825)Protein of unknown function (DUF2834)Protein of unknown function (DUF2835)Protein of unknown function (DUF2857)Protein of unknown function (DUF2891)Protein of unknown function (DUF2981)Protein of unknown function (DUF2982)Protein of unknown function (DUF2983)Protein of unknown function (DUF2984)Protein of unknown function (DUF2985)Protein of unknown function (DUF2988)Protein of unknown function (DUF2989)


E-F---- Mediator complex subunit 2Protein of unknown function (DUF3010)Protein of unknown function (DUF3012)Protein of unknown function (DUF3013)Protein of unknown function (DUF3014)

Sheet1

Protein of unknown function (DUF3015)EMF---- Subunit 21 of Mediator complex

Protein of unknown function (DUF3017)Protein of unknown function (DUF3023)Protein of unknown function (DUF3022)Protein of unknown function (DUF3025)

----B-- Protein of unknown function (DUF3027)EM----- Protein of unknown function (DUF3028)EM----- Mediator complex subunit 25 PTOV activation and synapsin 2----B-- Protein of unknown function (DUF3035)----B-- Protein of unknown function (DUF3036)

Protein of unknown function (DUF3037)Protein of unknown function (DUF3038)Protein of unknown function (DUF3039)Protein of unknown function (DUF3040)Protein of unknown function (DUF3042)

----B-- Protein of unknown function (DUF3043)------V Protein of unknown function (DUF2774)------V Protein of unknown function (DUF3045)EM----- Mediator complex subunit 25 C-terminal NR box-containing------V Base plate wedge protein 53------V Protein of unknown function (DUF2675)


----B-- Protein of unknown function (DUF3052)----B-- Protein of unknown function (DUF3053)


Protein of unknown function (DUF3060)EM----- Major ampullate spidroin 1 and 2EM----- Interferon regulatory factor 2-binding protein 1 & 2EMF---- Transcription factor/nuclear export subunit protein 2

Borrelia burgdorferi attachment protein P66 E--PB-- Thylakoid formation proteinEM----- Mediator complex subunit 25 von Willebrand factor type A



E-F---- Protein of unknown function (DUF3074)EM----- Mediator complex subunit 24 N-terminal

Protein of unknown function (DUF3080)Protein of unknown function (DUF3081)Protein of unknown function (DUF3082)Protein of unknown function (DUF3086)Protein of unknown function (DUF3087)Protein of unknown function (DUF3088)Protein of unknown function (DUF3089)

------V Protein of unknown function (DUF3092)Protein of unknown function (DUF3090)Protein of unknown function (DUF3091)Protein of unknown function (DUF3093)Protein of unknown function (DUF3094)Protein of unknown function (DUF3095)Protein of unknown function (DUF3096)Protein of unknown function (DUF3098)

Sheet1

Protein of unknown function (DUF3099)Protein of unknown function (DUF3104)Protein of unknown function (DUF3105)Protein of unknown function (DUF3106)Protein of unknown function (DUF3107)Protein of unknown function (DUF3112)

E-F---- Protein of unknown function (DUF3115)Protein of unknown function (DUF3117)

EM----- Mediator complex subunit 30Protein of unknown function (DUF3118)Protein of unknown function (DUF3119)Protein of unknown function (DUF3123)Protein of unknown function (DUF3125)Protein of unknown function (DUF3126)Protein of unknown function (DUF3127)

EMF---- Protein of unknown function (DUF3128)Protein of unknown function (DUF3129)Protein of unknown function (DUF3130Protein of unknown function (DUF3132)

E--P--- Protein of unknown function (DUF3133)Protein of unknown function (DUF3134)Protein of unknown function (DUF3135)Protein of unknown function (DUF3136)Protein of unknown function (DUF3137) Protein of unknown function (DUF3138)


----B-- Protein of unknown function (DUF3141)Protein of unknown function (DUF3144)Protein of unknown function (DUF3146)Protein of unknown function (DUF3149)Protein of unknown function (DUF3148)Protein of unknown function (DUF3152)Protein of unknown function (DUF3154)Protein of unknown function (DUF3155)Protein of unknown function (DUF3153)Protein of unknown function (DUF3156)Protein of unknown function (DUF3157)Type IV pilus biogenesis

EM----- Cell cycle regulatory proteinProtein of unknown function (DUF3158)

------V Glycoprotein UL132Protein of unknown function (DUF3110)Protein of unknown function (DUF3161)Protein of unknown function (DUF3165)

EM----- Protein of unknown function (DUF3166)Protein of unknown function (DUF3168)Protein of unknown function (DUF3169)Protein of unknown function (DUF3173)Protein of unknown function (DUF3175)Protein of unknown function (DUF3176)Protein of unknown function (DUF3179)Protein of unknown function (DUF3180)


EM--B-- Protein of unknown function (DUF3184)Protein of unknown function (DUF3185)

Sheet1

----B-- Protein of unknown function (DUF3186)Protein of unknown function (DUF3188)Protein of unknown function (DUF3189)Vitelline envelope receptor for lysinProtein of unknown function (DUF2795)NADH-dependant formate dehydrogenase delta subunit FdsDProtein of unknown function (DUF2798)

----B-- Protein of unknown function (DUF2877)Macrophage killing protein with similarity to conjugation protein

------V Protein of unknown function (DUF2873)Protein of unknown function (DUF2874)

E------ Glycosyltransferase (GlcNAc)----B-- Protein of unknown function (DUF2813)

Protein of unknown function (DUF3192)Tetrabrachion

E-F---- Antifungal proteinEM----- Potassium voltage-gated channelE--P--- Bromelain inhibitor VI----B-- Type II restriction enzyme MunIE-F---- Sgs1 RecQ helicaseEM----- Smad anchor for receptor activation (SARA)EM-P--- Antifungal peptideEM----- DNA ligase IVEM----- Adenomatous polyposis coli tumour suppressor protein

Loader and inhibitor of phage G40P------V Phi29 scaffolding protein-----A- Protein of unknown function (DUF3194)E--P--- ATP synthase F1 beta subunit

Initiator binding protein 39 kDa------V Regulatory protein Mnt

Protein of unknown function (DUF3195)EM----- Toxin BmKK4EM----- Tc3 transposase----B-- Protein of unknown function (DUF3196)----B-- Colicin DEM----- Programmed cell death activator EGL-1----B-- Chemotaxis-inhibiting protein CHIPS

Protein of unknown function (DUF3200)------V Domain of unknown function (DUF2828)

Protein of unknown function (DUF2895)Protein of unknown function (DUF2894)Protein of unknown function (DUF2897)Protein of unknown function (DUF3201)Protein of unknown function (DUF3005)Protein of unknown function (DUF2899)Protein of unknwon function (DUF3008)Protein of unknown function (DUF3202) Protein of unknown function (DUF3000)Protein of unknown function (DUF2950)Protein of unknown function (DUF3016)Protein of unknown function (DUF3018)Protein of unknown function (DUF3021)Membrane-integrating protein MisticProtein of unknwon function (DUF2893)Protein of unknown function (DUF3007)

EM----- Rab interacting lysosomal proteinR.HinP1I restriction endonuclease

Sheet1

EM----- FYVE-finger-containing Rab5 effector protein rabenosyn-5EM----- Natural killer cell receptor 2B4EM----- Prion-like protein DoppelEM----- Lens epithelium-derived growth factor (LEDGF)

Aromatic prenyltransferase Orf2Protein of unknown function (DUF3204)

EMF---- GLUT4 regulating protein TUG----B-- Protein of unknown function (DUF3205)

Protein of unknown function (DUF3206)------V RNA binding protein B2E------ Telomerase reverse transcriptase TEN domain------V Virion protein N terminal domain E------ Toxoplasma gondii micronemal protein 1 TgMIC1EM----- Antimicrobial chitin binding protein tachystatin B----B-- Colicin-E5 Imm protein


E-F---- Transcriptional regulatory protein LGE1E-F---- Protein of unknown function (DUF3210)----B-- DNA polymerase III polC-type N-terminus

Protein of unknown function (DUF3213) ------V Cricket paralysis virus, VP4

Ta0938----BA- Archaeal transcriptional regulator TrmBE-F---- Class II histone deacetylase complex subunits 2 and 3EM----- Transcriptional activator LAG-3----B-- Protein of unknown function (DUF3214)E-F---- Spindle-body formation-associated proteinEM----- B-cell lymphoma 9 proteinE-F---- Protein of unknown function (DUF3215)


EM----- Fanconi Anaemia group E protein FANCE----B-- Intrinsic membrane protein PufX

Thermoplasma acidophilum protein TA0956----B-- Protein of unknown function (DUF3219)EM----- Mouse development and cellular proliferation protein Cullin-7

Protein of unknown function (DUF3120)E-F---- Nuclear abundant poly(A) RNA-bind protein 2 (Nab2)----B-- Protein of unknown function (DUF3221)

Protein of unknown function (DUF3222)-----A- Chromatin protein Cren7EM----- C-terminal general transcription factor TFIIE alphaE-F---- Yeast phosphatidylinositol-4-OH kinase Pik1E--P--- Protein of unknown function (DUF3223)----B-- Copper resistance protein KE-F---- Subunit of cleavage factor IA Pcf11EM----- The ARF-like 2 binding protein BART

Melampsora lini avirulence protein AvrL567-AMinor type IV pilin, PilX

EM----- Coactivator-associated arginine methyltransferase 1 N terminalHexameric tyrosine-coordinated heme protein (HTHP)

-----A- Protein of unknown function (DUF3226)EM----- Snurportin1

Protein of unknown function (DUF3228)EM----- Cytoplasmic dynein 1 intermediate chain 2

Sheet1

E-F---- Mitochondrial division protein 1EMFP--- Nuclear pore localisation protein NPL4E-F---- Spindle pole body component Spc42p

Cell surface heme-binding protein ShpEM----- E3 ubiquitin ligase EDDEM----- Protein-tyrosine phosphatase receptor IA-2


Protein of unknown function (DUF3232)E------ Erythrocyte binding antigen 175

Protein of unknown function (DUF3233)EMF---- Afadin- and alpha -actinin-BindingEM----- Lamina-associated polypeptide 2 alphaE-F---- Single strand annealing-weakened 1EM----- Enhancer of mRNA-decapping protein 3- N terminal

ProtoglobinRestriction endonuclease BpuJI - N terminalAlpha helical Porin B

EM-P--- Proteasome Inhibitor PI31EM----- Mediator complex subunit 29EM----- Homeodomain leucine-zipper encoding, Homez----B-- Coiled-coil receptor-binding R-domain of colicin E2EMF---- Mediator complex subunit 27

Protein of unknown function (DUF3234)EM----- Mediator complex subunit 23

Protein of unknown function (DUF3235)----B-- FhuF 2Fe-2S C-terminal domain-----A- Protein of unknown function (DUF3236)EM----- NF-kappa-B essential modulator NEMO

Protein of unknown function (DUF3239)EM----- Antagonist of EGFR signalling, Argos

Proteinaceous host-selective toxin ToxAEM----- Insect antimicrobial peptide, stomoxyn

Protein of unknown function (DUF3242) EM----- Major prion protein bPrPp - N terminal----B-- Protein of unknown function (DUF3243)

Protein of unknown function (DUF3244)------V DNA polymerase catalytic subunit PolE-F---- Mediator complex subunit 3 fungalEM----- Mediator complex subunit 28E-F---- Protein of unknown function (DUF3245)

Protein of unknown function (DUF3246)EMF---- Mediator complex subunit 13 N-terminalEM----- Cartilage oligomeric matrix proteinEM----- Chromatin assembly factor 1 p150 subunitEM----- Shal-type voltage-gated potassium channels E-F---- Regulatory protein Sir1----B-- Copper binding periplasmic protein CusFEMFP--- Vacuolar protein sorting protein 36 Vps36

Protein of unknown function (DUF3247)EM----- Limkain b1E-F---- Scaffold protein Ste5-Fus5 binding region----B-- Telomeric repeat-binding factor 2----B-- Ubp3 associated protein Bre5EM----- WD repeat binding protein EZH2

Protein metal binding siteEM----- Protein of unknown function (DUF3250)

Sheet1

Transcription factor P53 - C terminal domainEM----- GA-binding protein alpha chain----B-- C3 binding domain 4 of IgG-bind protein SBI----B-- Protein of unknown function (DUF3251)


E-F---- Rap1 - C terminal domainEM----- T-cell surface glycoprotein CD3 zeta chainEM----- C terminal SARAH domain of Mst1EM----- Protein of unknown function (DUF3254)------V Replicase polyprotein 1abEMF---- Mediator complex subunit 16EM----- Troponin I residues 1-32------V ATP-dependant DNA helicase UvsW----B-- Chromosomal replication initiator protein DnaAEMF---- Telomere-length maintenance and DNA damage repair

Glycosylphosphatidylinositol-anchored merozoite surface proteinEM----- Mite allergen Blo t 5EM----- Vasodilator-stimulated phosphoprotein VASP

Protein of unknown function (DUF3256)----B-- C-terminal region of Pasteurella multocida toxin residues 569-1285EM----- C-terminal domain of RIG-I------V Virus neck protein------V P22 tail accessory factorEM----- Protein of unknown function (DUF3259)------V Bacteriophage T7 virion assembly proteinE-F---- Protein of unknown function (DUF2665)----B-- Competence regulator Spx (YjbD)----B-- Transcriptional activator TraM ----B-- Protein of unknown function (DUF3260)


----BA- Protein of unknown function (DUF3267)EM----- WW domain-binding protein 1

Complementary sex determiner proteinProtein of unknown function (DUF3268)Protein of unknown function (DUF3270)Protein of unknown function (DUF3271)Protein of unknown function (DUF3272)Protein of unknown function (DUF3275)Protein of unknown function (DUF3276)Protein of unknown function (DUF3279)Protein of unknown function (DUF3278)Protein of unknown function (DUF3281)Domain of unknown function (DUF3284)Protein of unknown function (DUF3285)Protein of unknown function (DUF3286)Protein of unknown function (DUF3287)Protein of unknown function (DUF3288)Protein of unknown function (DUF3289)Protein of unknown function (DUF2990)Protein of unknown function (DUF3290)Domain of unknown function (DUF3291)Protein of unknown function (DUF3292)Protein of unknown function (DUF3293)

EMFP--- V-ATPase subunit H

Sheet1

E-F-B-- Vacuole effluxer Atg22 likeEMF---- Myosin-binding striated muscle assembly centralE-F---- Protein of unknown function (DUF3295)EM----- UPF0506EMF---- Vesicle coat protein involved in Golgi to plasma membrane transportEMF---- DNA-directed RNA polymerase III subunit Rpc31

CGNR zinc fingerEMF---- Ribosome 60S biogenesis N-terminalEMFP--- Pre-mRNA splicing Prp18-interacting factorE-F---- Mitochondrial ribosomal protein subunit E-F---- G protein-coupled glucose receptor regulating Gpa2E-F---- Inner membrane protein import complex subunit Tim54EMF---- Endoplasmic reticulum-based factor for assembly of V-ATPase----B-- Peptidase C80 family

Thrombin inhibitor Madanin EMF---- Nucleoporin Nup120/160----B-- Mycothiol maleylpyruvate isomerase N-terminal domainEMFP--- RNA binding activity-knot of a chromodomain EMF---- Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-termEMF---- DNA replication and checkpoint proteinE-F---- Peptidase inhibitor I78 familyEM-P--- Di-glucose binding within endoplasmic reticulumEMF---- CCCH zinc finger in TRM13 protein

Pathogenicity factor----B-V Protein of unknown function (DUF3296)

Invariant surface glycoprotein----B-- DUF939 C-terminal domain----B-- Pathogenicity locusEMF---- Transcription- and export-related complex subunit------V Non-capsid protein NP1----B-- TilS substrate C-terminal domain----B-- Protein of unknown function (DUF3300)----B-- Protein of unknown function (DUF3298)----B-- Dicarboxylate transport----B-- Plasmid replication region DNA-binding N-term----B-- Localisation of periplasmic protein complexes----B-- Protein of unknown function (DUF3302)E-F---- Aluminium activated malate transporter


----B-- Protein of unknown function (DUF3311)----B-- Nitrous oxide-stimulated promoter

Suppressor of RNA silencing P21-likeEM----- Keratin-associated matrix----BA- Cobalamin synthesis G N-terminal----B-- Cobalamin biosynthesis central region----B-- L-arabinose isomerase C-terminal domainE-F---- Cell-wall adhesin ligand-binding C-terminalEMF---- COMPASS (Complex proteins associated with Set1p) component NE-F---- Hyphally regulated cell wall protein N-terminalE-F---- Histone lysine methyltransferase SET associatedEM----- Protein of unknown function (DUF3312)EM--B-- Protein of unknown function (DUF3313)EM----- GRB2-binding adapter (GAPT)----B-- DNA-directed RNA polymerase subunit beta

Type II secretory pathway pseudopilin ----B-- Lsr2

Sheet1

----B-- Cobalamin biosynthesis protein CobT VWA domain----B-- Domain of unknown function (DUF3315)

Protein of unknown function (DUF3316)E-F---- Septation initiationEMF---- Protein of unknown function (DUF3317)----B-- Protein of unknown function (DUF3318)EMF---- RNA polymerase I-specific transcription initiation factor Rrn7

Protein of unknown function (DUF3320)EMF---- 39S mitochondrial ribosomal protein L46 EMF---- Zinc-finger of the MIZ type in Nse subunitE-F---- Glycosyl hydrolase catalytic core----B-- Aconitate B N-terminal domain------V Baculoviridae late expression factor 5 C-terminal domainEMF---- FANCL C-terminal domain----B-- 4-hydroxyphenylacetate 3-hydroxylase N terminal

Uncharacterized protein conserved in bacteria N-term (DUF3322)Protein of unknown function N-terminus (DUF3323)Protein of unknown function C-terminal (DUF3324)

EM--BA- IMS family HHH motifEMF-BA- impB/mucB/samB family C-terminal----B-- Replication protein C C-terminal regionEMF---- Tom37 C-terminal domainEMF---- Centromere-associated protein KEM----- UDP-glucuronate decarboxylase N-terminal

Protein of unknown function (DUF3325)----B-- Protein of unknown function (DUF3326)----B-- Domain of unknown function (DUF3327)

Domain of unknown function (DUF3328)----B-- Domain of unknown function (DUF3329)

Domain of unknown function (DUF3332)Domain of unknown function (DUF3331)Domain of unknown function (DUF3333)Domain of unknown function (DUF3335)

E-F---- Domain of unknown function (DUF3336)EMF---- Domain of unknown function (DUF3337)EM----- Foie gras liver health family 1----B-- C-terminal domain of tail specific protease (DUF3340)EM----- Domain of unknown function (DUF3338)

Protein of unknown function (DUF3341)EM----- Domain of unknown function (DUF3342)----BA- Protein of unknown function (DUF3343)

Protein of unknown function (DUF3344)EM----- Protein of unknown function (DUF3345)

Protein of unknown function (DUF3346)Protein of unknown function (DUF3347)Protein of unknown function (DUF3348)Protein of unknown function (DUF3349)

EM----- Domain of unknown function (DUF3350)EMF---- Domain of unknown function (DUF3351)

Protein of unknown function (DUF3353)EM-P--- Domain of unknown function (DUF3354)

Domain of unknown function (DUF3355)Protein of unknown function (DUF3356)

E--P--- Domain of unknown function (DUF3357)----B-- Domain of unknown function (DUF3358)----B-- Protein of unknown function (DUF3359)EM----- Domain of unknown function (DUF3361)

Sheet1

----BA- Domain of unknown function (DUF3362)Protein of unknown function (DUF3363)

----B-- Domain of unknown function (DUF3364)Protein of unknown function (DUF3365)Domain of unknown function (DUF3366)Domain of unknown function (DUF3367)Domain of unknown function (DUF3368)Domain of unknown function (DUF3369)Protein of unknown function (DUF3370)

EM----- Domain of unknown function (DUF3371)E--PB-- Domain of unknown function (DUF3372)


EM----- Domain of unknown function (DUF3377)----B-- Domain of unknown function (DUF3378)EMF---- Domain of unknown function (DUF3381)----B-- Domain of unknown function (DUF3382)

Protein of unknown function (DUF3383)EMF---- Domain of unknown function (DUF3384)EMF---- Domain of unknown function (DUF3385)

Protein of unknown function (DUF3386)----BA- Domain of unknown function (DUF3387)----B-- Protein of unknown function (DUF3388)

Protein of unknown function (DUF3389)----B-- Domain of unknown function (DUF3390)

Domain of unknown function (DUF3391)Protein of unknown function (DUF3392)Domain of unknown function (DUF3394)

EMFP--- Domain of unknown function (DUF3395)Protein of unknown function (DUF3396)Protein of unknown function (DUF3397)

EM----- Domain of unknown function (DUF3398)EM----- Domain of unknown function (DUF3399)

Domain of unknown function (DUF3400)EMF---- Domain of unknown function (DUF3402)E--P--- Domain of unknown function (DUF3403)

Domain of unknown function (DUF3404)Protein of unknown function (DUF3407)Protein of unknown function (DUF3408)

------V Domain of unknown function (DUF3409)----B-- Domain of unknown function (DUF3410)

Domain of unknown function (DUF3411)----B-- Domain of unknown function (DUF3412)----B-- Domain of unknown function (DUF3413)EMF---- Protein of unknown function (DUF3414)E-F---- Domain of unknown function (DUF3415)----B-- Domain of unknown function (DUF3416)----B-- Protein of unknown function (DUF3417)----B-- Domain of unknown function (DUF3418)

Protein of unknown function (DUF3419)E--P--- Domain of unknown function (DUF3420)EM----- Protein of unknown function (DUF3421)


EM----- Protein of unknown function (DUF3424)Domain of unknown function (DUF3427)

Sheet1

E---B-- Cyanobacterial and plant NDH-1 subunit OEM----- Protein of unknown function (DUF3429)EM----- Domain of unknown function (DUF3432)

Protein of unknown function (DUF3433)EMF---- Domain of unknown function (DUF3434)

Protein of unknown function (DUF3435)EM----- Domain of unknown function (DUF3436)EMF---- Domain of unknown function (DUF3437)

Domain of unknown function (DUF3439)----B-- Domain of unknown function (DUF3440)EMF---- Domain of unknown function (DUF3441)

Protein of unknown function (DUF3445)EM----- Domain of unknown function (DUF3446)

Domain of unknown function (DUF3447)EMF-BA- Domain of unknown function (DUF3448)EMF---- Domain of unknown function (DUF3449)

Protein of unknown function (DUF3450)EM----- Domain of unknown function (DUF3451)EM-P--- Domain of unknown function (DUF3452)EMF---- Domain of unknown function (DUF3453)EM----- Domain of unknown function (DUF3454)

Protein of unknown function (DUF3455)EM----- Protein of unknown function (DUF3456)EMFP--- Spt5 transcription elongation factor, acidic N-terminal

Protein of unknown function (DUF3460)----B-- Protein of unknown function (DUF3461)EM----- Domain of unknown function (DUF3462)

Domain of unknown function (DUF3463)Protein of unknown function (DUF3464)Protein of unknown function (DUF3465)

E-F---- Protein of unknown function (DUF3468)EM----- Protein of unknown function (DUF3469)----B-- Domain of unknown function (DUF3470)----B-- Domain of unknown function (DUF3471)

Plant organelle RNA recognition domainEM----- Ankyrin-G binding motif of KCNQ2-3EMF---- THO complex subunit 1 transcription elongation factor


E--P--- Domain of unknown function (DUF3474)Domain of unknown function (DUF3475)Protein of unknown function (DUF3478)

----B-- Domain of unknown function (DUF3479)----B-- Recombination protein O N terminalEMF---- Protein of unknown function (DUF3321)EMFPB-- Scavenger mRNA decapping enzyme C-term bindingE-F---- G protein-coupled glucose receptor regulating Gpa2 C-termEM----- CAMSAP CH domain----B-- Alpha-2-macroglobulin MG1 domain----B-- Family 4 glycosyl hydrolase C-terminal domainEMFP--- Ubiquitin-2 like Rad60 SUMO-likeEM----- Zc3h12a-like Ribonuclease domainEM----- Shoulder domainEM----- Domain of unknown function (DUF3480)EM----- Domain of unknown function (DUF3481)


Sheet1

----B-- Domain of unknown function (DUF3484)Protein of unknown function (DUF3485)

----B-V Protein of unknown function (DUF3486)EMFPBA- Translation-initiation factor 2E-F---- Retrograde transport protein Dsl1 C terminal

Protein of unknown function (DUF3487)Domain of unknown function (DUF3488)Ribosomal S4P (gammaproteobacterial)Domain of unknown function (DUF3490)Protein of unknown function (DUF3491)Domain of unknown function (DUF3492)Protein of unknown function (DUF3493)Protein of unknown function (DUF3494)

EM----- Domain of unknown function (DUF3496)EMF-B-- MgsA AAA+ ATPase C terminalEM----- Domain of unknown function (DUF3497)EM----- Domain of unknown function (DUF3498)


----B-- Type I restriction and modification enzyme - subunit R C terminalEMFP--- Telomerase ribonucleoprotein complex - RNA binding domain

Domain of unknown function (DUF3502)EM----- Domain of unknown function (DUF3504)E-F---- Protein of unknown function (DUF3505)E--P--- Domain of unknown function (DUF3506)EM----- Transposase proteinEM----- Domain of unknown function (DUF3508)----B-- Type II transport protein GspHEM----- TAFA family


Domain of unknown function (DUF3511)EM----- Domain of unknown function (DUF3512)------V Phage protein CEM----- Domain of unknown function (DUF3513)


EM----- Domain of unknown function (DUF3518)EM----- Regulatory CLIP domain of proteinases

Protein of unknown function (DUF3521)EM----- Protein of unknown function (DUF3522)EM----- Domain of unknown function (DUF3523)EM----- Domain of unknown function (DUF3524)E--P--- Transcriptional regulator DELLA protein N terminal

Domain of unknown function (DUF3527)E-F---- Putative peptidase family

Protein of unknown function (DUF3529)EMFP--- Cytosine specific DNA methyltransferase replication foci domain


E-F-B-- Protein of unknown function (DUF3533)EM----- Voltage gated calcium channel subunit beta domain 4Aa N terminalEM----- Domain of unknown function (DUF3534)EMF---- Domain of unknown function (DUF3535)



Sheet1


E--P--- Protein of unknown function (DUF3542)EM----- heparan sulfate-N-deacetylaseEMF---- Domain of unknown function (DUF3543)EM----- Domain of unknown function (DUF3544)

Protein of unknown function (DUF3545)EMF---- Domain of unknown function (DUF3546)EM----- Domain of unknown function (DUF3547)EMF---- Domain of unknown function (DUF3548)

Protein of unknown function (DUF3549)EM----- Protein of unknown function (DUF3550/UPF0682)----B-- Domain of unknown function (DUF3552)EMF---- Domain of unknown function (DUF3554)EM----- KN motifE--P--- WAX2 C-terminal domain

Transmembrane protein of unknown function (DUF3556)EM----- Domain of unknown function (DUF3557)

GldM N-terminal domain----B-- Domain of unknown function (DUF3559)

Domain of unknown function (DUF3560)Protein of unknown function (DUF3562)Protein of unknown function (DUF3563)Protein of unknown function (DUF3564)Protein of unknown function (DUF3565)

----B-- Transmembrane domain of unknown function (DUF3566)EMF---- Spt20 family

Protein of unknown function (DUF3567)Protein of unknown function (DUF3568)Protein of unknown function (DUF3571)Protein of unknown function (DUF3572)Protein of unknown function (DUF3573)Protein of unknown function (DUF3574)

----B-- Domain of unknown function (DUF3576)----B-- Domain of unknown function (DUF3578)

Surface lipoprotein of Spirochaetales order----B-- Colicin C terminal ribonuclease domainEMF---- Splicing factor SF3a60 binding domainEMF---- Nuclear protein 96----B-- Polyribonucleotide phosphorylase C terminal

Protein of unknown function (DUF3579)SVM protein signal sequence

EM----- Period protein 2/3C-terminal regionSalivary protein of 15kDa inhibits CD4+ T cell activation

----B-- Stage III sporulation protein D------V Protein of unknown function (DUF3580)

SprA-related familyDNA/RNA tunnel of bacterial DNA dependent RNA polymerase

----B-- Protein of unknown function (DUF3582)----B-- N-acetylmuramoyl-l-alanine amidase------V Coronavirus polyprotein cleavage domainEM----- D domain of beta-TrCPEM----- Protein of unknown function (DUF3583)

Protein of unknown function (DUF3584)EM----- Male germ-cell putative homeodomain transcription factorEM----- Protein of unknown function (DUF3585)------V Protein of unknown function (DUF3587)

Sheet1

------V Open reading frame 6 from SARS coronavirusEMF---- PRP8 domain IV core

RNA polymerase Rpo13 subunit HTH domain----B-- RNA polymerase recycling family C-terminalE------ Spherulation-specific family 4EM----- Protein of unknown function (DUF3588)E--P--- Polyphenol oxidase middle domainEM----- Eukaryotic Mediator 12 catenin-binding domainEMF---- Eukaryotic Mediator 12 subunit domainEMFPB-V Putative lysophospholipase----B-- Putative lysophospholipaseEM----- Protein of unknown function (DUF3590)

Mannan-binding proteinE-F---- Eukaryotic translation initiation factor 4G1EM----- LPS binding domain of CAP18 (C terminal)------V Glycoprotein B N-terminal antigenic domain of HCMV

NADH dehydrogenase subunit 2 N-terminalPutative metal-binding domain of cation transport ATPase

EMFP--- Protein of unknown function (DUF3591)----B-- Protein of unknown function (DUF3592)

Protein of unknown function (DUF3593)EM----- Fibrinogen alpha C domain----BA- HsdM N-terminal domain

DNA replication regulator----B-- Stage V sporulation protein AAEM----- Protein of unknown function (DUF3595)----B-- Domain of unknown function (DUF3596)----B-- DNA polymerase III subunits tau domain IV DnaB-bindingEMFP--- Zinc-finger double-stranded RNA-binding-----A- Rubredoxin-like zinc ribbon domain (DUF35_N)

Bacteriocin class IIc cyclic gassericin A-likeRST domain of plant C-terminalWhite spot syndrome virus structural envelope protein VPMethanol-cobalamin methyltransferase B subunit

EM----- Prohormone convertase enzymeEM----- Chromosome passenger complex (CPC) protein INCENP N terminalEM----- I-kappa-kinase-beta NEMO binding domainEM----- TSG101 and ALIX binding domain of CEP55----B-- DNA binding domain of the motility gene repressor (MogR)

Bacterial lipoproteinDe novo homeodomain

EM----- Nup358/RanBP2 E3 ligase domainAcyl-CoA dehydrogenase C terminal

------V Viral/Archaeal nucleaseEM----- Fungal protease inhibitorEM----- Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domainE-F---- Fungal calcium binding proteinE-F---- Protein kinase Fus3-bindingEM----- FHA Ki67 binding domain of hNIFK----B-- Theoretical tuberculin protein----B-- Extracellular fibrinogen binding protein C terminal------V Domain of unknown function (DUF3597)EM----- Oxidative-stress-responsive kinase 1 C terminalEM----- Glutamine rich N terminal domain of histone deacetylase 4

Domain of unknown function (DUF3598)EM----- G protein-coupled receptor kinase-interacting protein 1 C termE-F---- Leucine permease transcriptional regulator helical domain

Sheet1

EM----- Hepatocyte growth factor-regulated tyrosine kinase substratePiwi/Argonaute/Zwille siRNA-binding domain

EM----- DNA polymerases epsilon N terminalEM----- Cell cycle regulated microtubule associated proteinEM----- beta-Glucocerebrosidase 2 N terminal

Immune evasion protein------V Catalytic beta propeller domain of bacteriophage endosialidase------V N terminal extension of bacteriophage endosialidase------V Catalytic domain of bacteriophage endosialidaseEMFP--- U1 small nuclear ribonucleoprotein of 70kDa MW N terminal----B-- Bacterial membrane protein N terminalE--P--- Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase AE-F---- Protein of unknown function (DUF3602)

Putative amidoligase enzymeMethylene-tetrahydrofolate reductase C terminal

----B-- Protein of unknown function (DUF3604)Putative peptidoglycan binding domain

EMFP--- Pre-mRNA splicing factor PRP21 like proteinEMF---- Rap1-interacting factor 1 N terminalEM----- Myogenic determination factor 5EMF---- RAVE protein 1 C terminalEM----- Fragile X-related 1 protein C terminal------V Bacteriophage head to tail connecting proteinEM----- Phosphorylated CTD interacting factor 1 WW domainE------ Merozoite surface antigen 2cE-F---- Protein of unknown function (DUF3605)EM----- Angiomotin C terminalE---B-- NAD(P)H binding domain of trans-2-enoyl-CoA reductaseE-F---- CTD kinase subunit gamma CTK3


E-F---- Temperature dependent protein affecting M2 dsRNA replicationE-F---- Temperature dependent protein affecting M2 dsRNA replicationEM----- Farnesoic acid 0-methyl transferase----B-- Arabinofuranosyltransferase A C terminalEM----- snRNA-activating protein of 50kDa MW C terminalEMF---- Chromatin assembly factor 1 subunit AEMFP--- DNA polymerase alpha subunit p180 N terminal

Insecticide toxin TcdB middle/C-terminal regionInsecticide toxin TcdB middle/N-terminal region

EMF---- Protein of unknown function (DUF3608)Protein of unknown function (DUF3609)

EM----- Pancreatitis induced protein 49 C terminal----B-- Bacterial virulence factor lipase N-terminal

Protein of unknown function (DUF3611)------V Spherical virus-type peptidaseEMFP--- Histone-binding protein RBBP4 or subunit C of CAF1 complex


EM----- CpG binding protein zinc finger C terminal domain----B-- Cytochrome c oxidase subunit IVE-F---- Chitin synthase III catalytic subunit

Protein of unknown function (DUF3610)E-F---- Chitin synthesis regulation, resistance to Congo red



Sheet1

Sex determination protein N terminalProtein of unknown function (DUF3619)

EM----- Brain specific membrane anchored proteinSignal transduction histidine kinase

------V Bacteriophage protein KEM----- Hox protein A13 N terminal------V Protein of unknown function (DUF3621)EM----- Cytoplasmic activation/proliferation-associated protein-1 C term------V Rotavirus VP1 structural protein

Bacterial type IIA DNA topoisomerase, B subunitProtein of unknown function (DUF3624)

EM----- Symplekin tight junction protein C terminalHydrophobic surface binding protein A

EM----- Ellis van Creveld protein 2 like protein------V Protein of unknown function (DUF3627)----B-- Protein of unknown function (DUF3628)EM----- CD99 antigen like protein 2

Protein of unknown function (DUF3629)----B-- Membrane bound L-sorbosone dehydrogenaseEM----- Beta-casein like protein

Protein of unknown function (DUF3630)Inclusion body protein

EM--B-- Protein of unknown function (DUF3631)EM----- Neurogenesis glycoproteinEM----- KIF-1 binding protein C terminalEM----- Transcription factor protein N terminal------V Nepovirus subgroup A polyprotein E--P--- NPR1/NIM1 like defence protein C terminal

Inner membrane complex proteinE--P--- Protein of unknown function (DUF3633)EM----- Segment polarity protein dishevelled (Dsh) C terminalEM----- Intraflagellar transport complex B protein 46 C terminal

Membrane bound FAD containing D-sorbitol dehydrogenase Tryptophan-Threonine-rich plasmodium antigen C terminal

----BA- Type 5 capsule protein repressor C terminalProtein of unknown function (DUF3634)

------V T4 bacteriophage base plate protein----B-V Helix-turn-helix domain----B-- Helix-turn-helix domain of alkylmercury lyaseEMFP--- TATA element modulatory factor 1 TATA bindingE--PBA- FtsZ family, C-terminal domainEMF---- Rpp20 subunit of nuclear RNase MRP and PEMFP--- TATA element modulatory factor 1 DNA bindingEMF---- Domain of unknown function (DUF3635)

Protein of unknown function (DUF3636) ----B-- Bacterial methyl-accepting chemotaxis protein N terminal EMF---- Rix1 complex component involved in 60S ribosome maturationEM----- Myotubularin protein EM----- SOX transcription factor

Protein of unknown function (DUF3637) Protein of unknown function (DUF3638)

EMF---- Protein of unknown function (DUF3639) ----BA- Ultra-violet resistance protein B

Protein of unknown function (DUF3641) EM----- Holliday junction recognition protein-associated repeatEM----- Holliday junction regulator protein family C-terminal repeatEMF---- CLASP N terminal

Sheet1

EMF---- Sterol-sensing domain of SREBP cleavage-activationE-F---- CTD kinase subunit gamma CTK3 C-terminusE-F---- Ca2+ regulator and membrane fusion protein Fig1EMFP--- Snare region anchored in the vesicle membrane C-terminusEMF---- Eukaryotic translation initiation factor 3 subunit G ----B-- Bacterial adhesion/invasion protein N terminal

Down syndrome cell adhesion molecule C terminal EM----- Protein of unknown function (DUF3643) E--P--- Phospholipase D C terminal

Protein of unknown function (DUF3644) EM----- Paired box protein 7

DNA polymerase III gamma and tau subunits C terminalPhage protein

EM----- Cancer susceptibility candidate 1 Pyruvate ferredoxin oxidoreductase beta subunit C terminal

----B-- Protein of unknown function (DUF3650) EM----- Gonadotropin hormone receptor transmembrane region ----BA- Cobalt ATP-binding cassette C terminal EM----- Protein of unknown function (DUF3651)EM----- Huntingtin protein region EM----- Double-sex mab3 related transcription factor 1

Phage proteinE-F---- Protein of unknown function (DUF3654) ------V Protein of unknown function (DUF3655)

Gill-associated viral 3C-like peptidase------V Tungro spherical virus-type peptidaseE-F---- Retrotransposon peptidase------V Severe acute respiratory syndrome coronavirus 3b proteinE-F---- Ty3 transposon peptidase----B-- Papain-like cysteine protease AvrRpt2

Pseudomurein endo-isopeptidase Pei------V Pestivirus NS2 peptidase

Dual-action HEIGH metallo-peptidase----BA- Camelysin metallo-endopeptidase----B-- Selenocysteine synthase N terminal----B-- Protocatechuate 3,4-dioxygenase beta subunit N terminal----B-- Collagenase EM----- Protein of unknown function (DUF3657)

Protein of unknown function Protein of unknown function (DUF3659)

EMFP--- U3 small nucleolar RNA-associated protein 10 E--P--- Receptor serine/threonine kinase ----BA- Branched-chain amino acid ATP-binding cassette transporterEMF---- Vaculolar membrane protein

Protein of unknown function (DUF2662) Surface protein

EM----- Homeobox protein Ribose-5-phosphate isomerase

EMF---- P-type ATPase transporter------V Poxvirus DNA dependent RNA polymerase 30kDa subunit

Protein of unknown function (DUF3667)------V Poxvirus DNA dependent RNA polymeraseEM----- Protein of unknown function EM----- Zinc finger protein

Acyl-CoA dehydrogenase N terminal SNF2 Helicase protein Protein of unknown function

Sheet1

EM----- Condensin II non structural maintenance of chromosomes subunitEM----- Kinesin protein 1BEM----- Plasma membrane calcium transporter ATPase C terminal

Protein of unknown function (DUF3673) ------V RNA dependent RNA polymerase

Branched-chain amino acid aminotransferase Protein of unknown function (DUF3675) Protein of unknown function (DUF3676)

EMFP--- Abscisic acid G-protein coupled receptor EM----- Protein of unknown function (DUF3677) ------V Parvovirus non-structural protein 1

Malate dehydrogenase enzyme Protein of unknown function (DUF3678)

EMFP--- Ubiquitin-specific protease 7 E---B-- Glutamine synthetase type III N terminal

Glycogen debranching enzyme N terminalEM----- Melanoma associated antigen family N terminal


EM----- AT-hook-containing transcription factorEM----- Sox developmental protein N terminal ----B-- Flagellin protein


EM----- Kinesin associated protein----B-- von Willebrand factor EMF---- Vacuolar protein sorting protein 11 C terminalE---B-- Protein of unknown function (DUF3685) EM----- Protein tyrosine phosphatase N terminal E-F---- GPI-anchored cell wall organization proteinEMF---- Dynein associated protein EM----- Inositol phosphatase EM----- Tuftelin interacting protein N terminal

D-Ala-teichoic acid biosynthesis proteinEMF---- NER and RNAPII transcription protein n terminal------V Protein of unknown function (DUF3688) ----B-- DNA helicase IV / RNA helicase N terminalEM----- Protein of unknown function (DUF3689) E-F-B-- Maltose acetyltransferase EMF---- Proteasome beta subunits C terminal

Glutamate dehydrogenase N terminal------V Cucumber mosaic virus 1a protein ----B-- Type III secretion system leucine rich repeat protein

CRISPR-associated protein EM----- Suppressor of Fused Gli/Ci N terminal binding domain

Phage related proteinEM----- Kinesin protein EM----- Polo kinase kinase ------V Amdovirus non-structural protein

Protein of unknown function (DUF3696)----B-- Sex factor F TraW protein N terminalEM----- Ubiquitin-associated protein 2

Protein of unknown function (DUF3698) EM----- Protein of unknown function (DUF3699) E--P--- Aluminium induced protein

Phage integrase proteinEM----- E3 Ubiquitin ligase

Sheet1

EM----- Lymphocyte signaling adaptor proteinImpA domain protein Protein of unknown function (DUF3704)

EM----- Nuclear coactivatorEM----- Breast carcinoma amplified sequence 3


EM----- Protein of unknown function (DUF3695) Vegetative insecticide protein 3A N terminal

EM----- Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2E--P--- Basic leucine-zipper C terminal

Phosphate ATP-binding cassette transporterProtein of unknown function (DUF3710)

------V Cucumber mosaic virus 1a protein C terminal Aluminium induced protein Protein of unknown function (DUF3712)

----B-- Protein of unknown function (DUF3713)Human Cytomegalovirus UL139 proteinProtein of unknown function (DUF3714)

EM----- Protein of unknown function (DUF3715)EM----- Smoothelin cytoskeleton protein


EMF---- Mitochondrial degradasome RNA helicase subunit C terminalProtein of unknown function (DUF3718)

EM----- Protein of unknown function (DUF3719)Protein of unknown function (DUF3720) Protein of unknown functionProtein of unknown function (DUF3724)

------V Cytomegalovirus glycoprotein N terminal------V Protein of unknown function (DUF3725)------V dsDNA virus glycoprotein L C terminal

Protein of unknown function (DUF3726) ------V Protein of unknown function (DUF3729)

Protein of unknown function (DUF3727) EM----- Xylosyltransferase C terminal EM----- Protein of unknown function (DUF3730)

DNA-K related protein EM----- Neuronal helix-loop-helix transcription factor EM----- Leucine-rich repeat containing protein 8

Patatin phospholipase EMFP--- Protein of unknown function (DUF3735)----B-- DNA transporter EM----- Protein of unknown function (DUF3736)

Protein of unknown function (DUF3737) EMF---- Pre-mRNA splicing factor

Protein of unknown function (DUF3738)----B-- Lysine-2,3-aminomutase E--P--- Blue/Ultraviolet sensing protein C terminalEM----- Capicua transcriptional repressor modulator EM----- Sulfatase proteinEM----- Tyrosine hydroxylase N terminal E-F---- Transcriptional activator of glycolytic enzymes

Poly-beta-hydroxybutyrate polymerase N terminalProtein of unknown function (DUF3741)Protein of unknown function (DUF3742)

EMFP--- Protein of unknown function (DUF3743)

Sheet1

Thiamine pyrophosphokinase C terminal----B-- Cob(I)alamin adenosyltransferase N terminal ----B-- ATP-binding cassette cobalt transporter----B-- Serine endopeptidase inhibitors------V Protein of unknown function (DUF3746)----B-- Type III restriction/modification enzyme methylation subunit

Protein of unknown function (DUF3747)----B-- Protein of unknown function (DUF3748)EM----- Leukocyte receptor CD45----B-- Acetyltransferase, GNAT familyEMF---- NMDA receptor-regulated protein 1 EM----- Protein of unknown function (DUF3752)----B-- 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal----B-- 120kDa Rickettsia surface antigen------V Protein of unknown function (DUF3753)EM----- Protein of unknown function (DUF3754)EM----- Peroxisome proliferator-activated receptor gamma N terminalEM----- Myotubularin-associated protein

Protein of unknown function (DUF3755)EMF---- Tripeptidyl peptidase II EM----- Tripeptidyl peptidase II N terminal

Protein of unknown function (DUF3758)Protein of unknown function (DUF3761)Phophatidylserine decarboxylase

EMF---- Methyltransferase involved in Williams-Beuren syndromeE--P--- Acyl-ATP thioesterase


Protein of unknown function (DUF3764)EM----- Rhomboid serine proteaseEM----- 87kDa TransposaseEMF---- Protein of unknown function (DUF3767)EM----- T-box transcription factor

Protein of unknown function (DUF3769)------V Protein of unknown function (DUF3770)EM----- Casein kinase 1 gamma C terminalEM----- Tumour necrosis factor receptor superfamily member 19

Protein of unknown function (DUF3772)Wound-induced protein

EM----- Suppressor of cytokine signallingEMF---- Tubulin folding cofactor D C terminal

Ribosome recycling factor ----B-- F sex factor protein N terminal

Protein of unknown function (DUF3775)Iron-Sulfur binding protein C terminal

EMF---- Minichromosone maintenance protein 2Protein of unknown function (DUF3778)

[xls] · web viewflagellar p-ring protein stig1 pf04885 stigma-specific protein, stig1 duf3295...

Documents