year 1 report - ccp4 · throughput structure determination, ... r. flaig (diamond light source) who...

1st Annual Report

MAX-INF2

European Macromolecular Crystallography Infrastructure Cooperation Network

Integrating Activity

implemented as a

Coordination Action Contract number: [RICA-CT-2004-505977] Project Co-ordinator: MAX-lab, Lund University, Sweden Project website: http://www.ccp4.ac.uk/maxinf/ Reporting period: from 01/12/2004 to 30/11/2005

Project funded by the European Community under the “Structuring the European Research Area” Specific Programme

Research Infrastructures action

2 Contract [RICA-CT-2004-505977] Annual Report

A. ACTIVITY REPORT 1. PROGRESS REPORT .........................................................................................................

1.1 Summary of the activities and major achievements ................................................. 3 1.2 Management Activity ............................................................................................... 3 1.3 Networking Activities (other than management) ....................................................... 4 1.3.1 Activity N1: Theoretical Schools...................................................................................4 1.3.2 Activity N2: Practical Workshops ...................................................................................5 1.3.3 Activity N2: Coordination Meetings................................................................................9 1.3.4 Activity N2: Web site .......................................................................................................9

1.4 Update of the non-confidential Project information................................................. 10

2. LIST OF DELIVERABLES .............................................................................................. 11 3. USE AND DISSEMINATION OF KNOWLEDGE ......................................................... 12

ANNEXES

Annex 1 - Summaries and main conclusions of the General Meetings Annex 2 – CD-ROM with the deliverables produced during the reporting period

A. ACTIVITY REPORT


1. Progress report 1.1 Summary of the activities and major achievements MAX-INF2 has two main defined goals: firstly to achieve long-term integration of the infrastructure for macromolecular crystallography (MX) in Europe, secondly to organise workshops and schools for the European MX user community, in particular for young scientists (Ph.D. students and postdocs). The two approaches are tightly integrated, since one way to ensure effective use of the MX facilities is to educate the user community, the infrastructure stakeholders, in the intricacies of their operation, which leads to good common practice. Basic training in the methods in and around MX is also highly desirable in this respect. MAX-INF2 aims to continue the work of the highly successful FP5 network MAX-INF (record number 19468). The infrastructure integration goals of MAX-INF2 were to be achieved primarily through the Integration Workshops (Activity N3), which would promote a culture of cooperation between researchers at the different European infrastructure providers involved in MAX-INF2, as well as software and hardware developers working together with and around these facilities. Knowledge would also be input from outside Europe by the invitation of a small number of select non-EU speakers involved in similar infrastructure. The first workshop was due to take place in Year 2, and it will be held on 27th–28th February 2006 at EMBL Hamburg. During Year 1 the coordinator has been consulting with researchers at EMBL Hamburg in the planning of this meeting. The activities of MAX-INF2 have thus focused mainly on the organisation of Practical Workshops (Activity N2) and Theoretical Schools (Activity N1). Six workshops have taken place during Year 1, somewhat more than was originally projected, in diverse thematic areas. These are detailed in section 1.3.2. The practical workshops have all been a great success and have met with a very positive response from the students involved. Full details of student evaluations for most of the workshops are presented in Annex 2 (CD-ROM). The Theoretical School was also planned for Year 2, and some preparatory activities have taken place during Year 1. However a full list of speakers has been prepared and the administrative side of the meeting (which will take place in Como, Italy, in May 2006) is in place (see section 1.3.1). 1.2 Management Activity

Date Title/subject of meeting

Location Number of attendees

Website address

8/1/04 1st MAX-INF2 Coordination Meeting

University of Reading, UK

8 http://www.ccp4.ac.uk/maxinf2

Details of the first general meeting are given in Annex 1. In addition to the general meeting, a telephone conversation was held between Derek Logan (MAX-INF2), Colin Nave (BIOXHIT) and Paul Tucker (I3-SFS) about the possibility of holding a joint workshop outlining the latest developments in synchrotron beamline technology and software from a user perspective. Developments driven by the latter two networks have been rapid in the past few years and a significant amount of time goes into adapting what has changed each time users visit a facility. This can lead to inefficiency, since visits are often short (24 hours) and

A. ACTIVITY REPORT


highly intensive. A focused presentation of the different possibilities would be very attractive to users and desirable from the point of view of good common practice and education of future infrastructure stakeholders. The focus of such a workshop would be on how to do a macromolecular crystallography experiment most effectively at each of the major European synchrotron radiation sources, clearly delineating the common features as well as the unique features of each facility. It was decided to aim to hold such a workshop in the second half of 2006 at the ESRF, and a letter was sent to Sine Larsen, scientific director of the ESRF, with this proposition.

1.3 Networking Activities (other than Management) 1.3.1 Activity N1: Theoretical Schools

Participant number1 1

Participant short name2 MAX-lab Total

Person-months3 0.25 (0) 0.25 (0)

Work has begun to organise the first Theoretical School, which will take place at Centro del Casino in Como, Italy, between 21–25 May 2006. Offers from Centro Volta itself and from a Swedish conference organiser, BTI Nordic Event and Conference (with whom Lund University has a framework agreement) were compared and it was decided that the economically most advantageous result would be achieved by subcontracting most of the administrative effort of arranging the school to BTI while relying on Centro Volta for the purely local arrangements. As this arrangement was not specified in Annex I, the MAX-INF2 partners were asked for permission to seek an amendment to the contract to allow subcontracting of the practical aspects of the School's organisation. All of the partners have now replied positively to this request and permission will be requested after the submission of this report.

The scientific content of the Theoretical School and the invited speakers was arranged in collaboration with two members of the Scientific Advisory Group, Nederlands Kanker Instituut in Amsterdam and IRBM in Rome, who had a previous commitment to contributing to the scientific content. The final programme is expected to be ready in month 13. This organisation has taken place by e-mail and telephone conferences

Deliverables and milestones: Deliverable/ Milestone No

Deliverable/Milestone Name Workpackage /Task No

Lead Contractor(s)

Planned (in months)

Achieved (in months)

1 Theoretical School 1 18 n/a

1 Lead participant first 2 Use the same contractor short names and numbers indicated in the table “list of participants” in Annex I of

your contract. 3 AC contractors must include both the total estimated human effort (including permanent staff) and, in brackets,

additional staff only.

A. ACTIVITY REPORT


1.3.2. Activity N2: Practical Workshops

Participant number4 3 4 7 8 14 15

Participant short name5 EMBL ESRF SOLEIL Diamond MRC ITQB Total

Person-months6 1 (0) 2 (0) 1 1 1 7.05 (0) 11.05 (0)

A total of six practical workshops were held during period 1, as described in the table below. Workshop 7, on robotic approaches to macromolecular crystallization, did not take place and Workshop 8 was postponed until autumn 2006.

Date Title/subject of meeting /workshop

Location Number of attendees

Website address

13–14 December 2004

Future directions in Macro-Molecular Crystallography

Synchrotron SOLEIL, France

53 (total)

15–21 June 2005

EMBO / MAX-INF2 Practical Course on Exploiting Anomalous Scattering in Macromolecule Structure Determination

ESRF, Grenoble, France

24 students, 22 tutors

http://www.synchrotron-soleil.fr/EMBO2005

18-23 August 2005

IUCr / MAX-INF2 School on Crystallographic Computing

University of Siena, Italy

53 students http://www.iucr.ac.uk/iucr-top/comm/ccom/siena2005/

19-24 September 2005

1st ESF / MAX-INF2 course: Membrane proteins, the rocky road from gene to structure

ITQB, Oeiras, Portugal

31 students, 11 invited speakers, 5 demonstrators

25–27 October 2005

Molecular modelling for macromolecular crystallographers (MM4MX)

Diamond, UK

26 students http://www.ccp4.ac.uk/maxinf/mm4mx

9–16 November 2005

M2M-5: From measurements to model

EMBL Hamburg, Germany

20 students, http://www.embl-hamburg.de/workshops/2005/m2m5/

A short summary of each workshop will now be given. Full details can be found on the CD-ROM of deliverables (Annex 2). 1.3.2.1. Future directions in Macro-Molecular Crystallography, SOLEIL, France 53 speakers and participants met in the very recently opened “Communications Centre” building at SOLEIL for a series of seminars and animated discussion on several evolving methods in synchrotron radiation protein crystallography. These two days of presentations covered the development of a number of new strategies, techniques and methodologies addressing some of the principal problems in modern data collection. During his introduction 4 Lead participant first 5 Use the same contractor short names and numbers indicated in the table “list of participants” in Annex I of


additional staff only.

A. ACTIVITY REPORT


Jean-Pierre Samama (CNRS, Strasbourg) outlined the main directions of current research themes: high throughput structure determination, the design and optimisation of active molecules (inhibitors etc.), and fundamental research on very complicated systems (complexes, membrane proteins etc.). He pointed out that the technical requirements of these various themes require quite different beamline resources. Examples of difficult structural projects were presented in several domains, notably virus structure (S. Duquerroy, Virology laboratory, CNRS Gif), transcription complexes (H. Kettenberger from P. Cramer’s group in Munich). In this type of project, large unit cell dimensions and very small, fragile crystals imply the necessity for optimised strategies for the collection and exploitation of data, and the necessity to screen large numbers of crystals for a successful resolution to the projects. The case of virus crystallography and the study of prion proteins (M. Knossow, CNRS Gif-sur-Yvette) led to a lively debate about the requirements for beamlines with P3 containment facilities, their administration and the possibility of conversion between P2 and P3 facilities by administrative re-classification for the duration of certain projects. This discussion was aided by the presence of R. Flaig (Diamond Light source) who was able to report on progress towards the P3 compatible beamline in the planning stage at DLS. A series of presentations then underlined the complementarity of low resolution techniques such as SAXS for the identification of conformation in solution of the following of conformational changes in dynamic processes (P. Vachette, Université Paris Sud), and the use of cryo-electron microscopy to obtain low resolution models as a complementary method of solving the phase problem (G. Schoehn, EMBL Grenoble). Other developing methods using synchrotron radiation were presented by D. Bourgeois (IBS, Grenoble), who explained methods used at the ESRF for following dynamic processes either using Laue protein crystallography, or by trapping and characterising slowly changing intermediate states; and also by E. Girard (SOLEIL) who presented the progress made in studying protein structure at high pressure using a diamond anvil cell, and also alluded to the advantages that can accrue in using ultra-short wavelengths for data acquisition. Joe Patel (Astex Technologies) presented the “industrial approach” to high throughput data collection, and indicated the gain that modern automated data collection techniques can bring in terms of optimisation of experimental conditions and efficiency of data collection. The second day concentrated on technological developments at European synchrotrons, methodological developments, and extended discussions about the use of wavelengths at the soft and hard extremes of the X-ray spectrum:

- Micro-focus applications were presented by C. Nave of CCLRC Daresbury Laboratory, who also pointed out the advantages of focussing the beam on the data detector for improved spatial resolution.

- C. Schulze-Briese presented the advances made at the Swiss Light Source, and discussed the optimisation of the irradiated volume of crystal sample.

- L. Jacquamet, ESRF, presented the work of the beamline FIP on the screening of samples contained in the crystallisation plate by passing them in front of the X-ray beam using a robot arm.

- Radiation damage, its modelling, and how to use this in order to complement phase information was discussed both by M. Schiltz (Lausanne) and G. Bricogne (Global Phasing), who reminded us on several occasions the importance of the measurement of good data at low resolution.

- Examples of structures solved at very short (0.3-0.4 Å, R. Fourme, SOLEIL), lomg (1.5-1.8 Å , M. Walsh, ESRF Grenoble) and very long (2-7 Å, R. Kahn, IBS Grenoble) wavelengths were then presented.

The meeting closed with a long discussion on the advantages of the various wavelength ranges and the impact of the improved phasing reported by modelling of dose rate and site dependent radiation damage. 1.3.2.2. Exploiting Anomalous Scattering in Macromolecule Structure Determination, ESRF, France There was an outstanding response to the announcement, with almost 100 applicants from over 20 countries. This response is twice that of the previous course held at the EMBL & ESRF in 2003. Despite the large number of applicants, we endeavoured to select the best candidates while ensuring an even representation of students from labs based on geographical location and nationality. Special consideration was given to smaller laboratory groups as well as those who have not benefited from previous courses of this nature. The course was held over seven days and consisted of two days of lectures, two days of beamline practicals and two days of software tutorials. The first day was dedicated to introductory lectures to give all of the students a firm basis of the fundamentals. This included an introduction to synchrotron radiation and anomalous scattering, beamline instrumentation, data collection strategies, data integration, data scaling, substructure solution, phase calculations and map interpretation. Days 2 & 3 started with two 45-minute morning lectures on topics which the

A. ACTIVITY REPORT


students would use in the beamline practicals, in particular data integration software. These lectures were immediately followed by the beamline practicals. The students were divided into groups of four, and they remained on one of six beamlines for the rest of the day. Each group had the chance to work on a bending magnet beamline (BM14, BM16 or BM30) and an undulator beamline (ID14-4, ID23 or ID29). The beamline staff provided test samples which the students could mount on the goniometers, collect X-ray diffraction images from and process the data to determine the macromolecular structures. Later in the evenings (20.00 – 24.00), the students were allowed to continue experiments on the beamlines with their own samples. This organisation permitted the tutors to use proven samples, which are better for teaching the students the methods and possible problems, while also allowing the students to work on their own samples afterwards. Seven students brought samples, and X-ray diffraction data were collected from all of them. The tutorial days also started with two 45 minute morning lectures introducing the software that the students would work with. A total of six software tutorials were held on days 4 & 6. Most, if not all, of the students clearly stated at some time that the practical course exceeded their expectations. Virtually all of the students felt that the lectures covered the material well. For full details of the evaluation and of the distribution of students, see Annex 2. Overall, the practical course was an outstanding success and timely in an era where much in the field of X-ray crystallography is becoming increasingly automated. This is especially important when an increasing number of young crystallographers come from a molecular biology background. Consequently, this course has allowed many young scientists to better understand the beamlines at synchrotrons, as well as, the theory and methods employed in automated macromolecular structure determination. With the imminent arrival of new synchrotrons in Europe, it will be important to build up our base of scientists in this domain. 1.3.2.3. IUCr/MAX-INF2 School in Crystallographic Computing 18 - 23 August 2005 (IUCr = International Union of Crystallography) The school was spread over 6 days, had 34 lectures and four practical sessions in the "full day" afternoons. 18 speakers covered programming methods used in each of the three main areas of crystallography, viz. powder diffraction, small molecule crystallography and macromolecular crystallography. 53 students attended from across the world. Extensive details of the course content are available at the web site: http://www.iucr.ac.uk/iucr-top/comm/ccom/siena2005/ and the most important points have been included in Annex 2. 13 European Union students applied for bursaries and had their costs reimbursed from the funds available from MAX-INF2. 1.3.2.4. Membrane Proteins: the Rocky Road from Gene to Structure, ITQB, Portugal The course lasted for 6 days and included lectures in the mornings and tutorial, practical and poster sessions in the afternoon. The lectures covered a wide range of topics related to membrane proteins, namely overexpression, purification, crystallization, and tools for structural and functional analysis of membrane proteins. There was a good balance between lectures covering basic topics and state-of-the-art methodologies, and lectures focusing on more specific subjects with presentation of some examples. Since most of the participants had some experience on the area, they raised many questions during the lectures, so they were all very participative. The lectures were open to researchers with interest in the field, so all the 11 Portuguese students that applied to participate in the course were able to attend the theoretical lectures. Some students and more senior scientists from ITQB also came to the lectures. The students were divided into two groups in the afternoons - one for the laboratorial practical session, the other group for the tutorial and poster session. Extended discussion among the speakers and participants took place during tutorials and the poster sessions. There were three laboratory sessions – handling of membrane proteins, screenings and crystal optimization, and crystallization with lipidic cubic phases (demonstration). See the detailed programme in Annex 2 for more details. The course evaluation by the students after the course was very positive - they learned a lot, had plenty of time for informal discussion, which was good to raise some questions and ask about specific problems they were facing during their research projects. Some suggested a bit shorter course (4 to 5 days, instead of 6). Hotel and social events were most appreciated. Participants had time to learn science and have fun.

A. ACTIVITY REPORT


We had 11 invited speakers to lecture during the course, from different European laboratories with varied expertise. Since we received almost 90 applications for 25 places, we increased the number of selected students to 31 plus 5 demonstrators, who helped in the preparation and tutoring of the practical sessions. The candidates were selected based on their CV, letter of motivation and geographic provenance. Gender distribution was 20 male and 16 female participants (students and demonstrators). Four students from the Membrane Protein Crystallography Group actively participated in the local organising committee and their help was crucial for the success of the course. We also had some secretarial support. 1.3.2.5. Molecular Modelling for Macromolecular Crystallographers (MM4MX) The objective of this workshop was to introduce the concepts of molecular modelling and computational chemistry to macromolecular crystallographers. Macromolecular crystallography (MX) provides a method of determining the 3D structure of a macromolecule. Molecular modelling is not a technique which is widely used by the MX community; however it can be used to provide information which cannot be obtained from the crystallographic structures alone. For example, modelling can be used to investigate the dynamics of a molecule; to study the mechanism of an enzyme; to screen potential ligand molecules in silico or to predict binding interactions either between a ligand and a macromolecule or between two macromolecules. This workshop aimed to provide the participants with enough background knowledge of molecular modelling to allow them to use the techniques as part of their overall study of macromolecular systems.

The workshop was held over three days. There were 48 applications for the workshop and places were offered to 26 people. Of these 26 there were 6 from industry, 13 Ph.D. students and 7 post-doctoral researchers.

Experts in the field of computational chemistry were invited to give lectures or tutorials at the workshop. The workshop was advertised by placing announcements on the CCP4 bulletin board and the International Union of Crystallography web pages and by sending posters to various institutions in the UK and in Europe. The workshop comprised lectures covering basic principles and specific topics in molecular modelling, practical tutorial sessions and presentations given by the workshop participants. The workshop was organised so that there were plenty of opportunities for the participants to discuss their research interests with the tutors. For example the participants all had to give a five minute presentation of their work. The benefit of this was that the tutors were able to give specific advice to the participants and in a few cases arrangements were made to collaborate on projects after the workshop had finished. The participants were provided with feedback questionnaires at the end of the workshop and the results from these were very positive (see Annex 2 for details.) The participants were also given a test on what they had learned on the course (questions were prepared by each tutor) and the results showed that the participants had gained a large amount of information from the course. Material from the workshop, such as PowerPoint presentations of the lectures and the test questions, has been made available on the MAX-INF2 website. 1.3.2.5. Methods in macromolecular crystallography: from measurements to model (M2M-5) The M2M course was established at the EMBL in Hamburg in 1993 and is at the forefront of training in structural biology, covering the essential steps in determining biological structures. Many of the leading figures in macromolecular crystallography have participated in these courses, either as students or lecturers. Since inception, more than 150 young researchers have obtained state-of-the-art training. The M2M-2005 course included practicals at synchrotron beamlines, computational tutorials and lectures on the use of synchrotron radiation and beamline equipment, sample handling and carrying out an experiment. Other topics included data processing, structure solution, model building and software pipelines. The tutors included 15 external researchers and a large EMBL Hamburg team. There were 139 applications to the course and 20 external attendees – mostly pre- and post-doctoral fellows - were invited. The number of applicants was a considerable increase compared to the 80 received for the previous course in 2003. The applications were evaluated by 5 members of the course organising committee using the following criteria: • Preference was given to young investigators: experienced pre-doctoral students or beginning fellows with

a post-doctoral degree. • Publications, particularly those relevant to the subject of the course. • Current research and its relevance to the subject of the course.

A. ACTIVITY REPORT


• Expected value of the course to the applicant’s research career. • Recommendations and letters of support if available. In addition, the applicants were requested to value their experience with the topics of the course (methods and software) and this was taken into account. The experience of participants in the topics of the course was analyzed. The attendees represent a wide spread of countries and nationalities. At the end of the course attendees were asked to fill in the questionnaire, a survey of responses is given below. Further details can be found in Annex 2. 1.3.3. Activity N3: Integration Workshops Participant number7 3

Participant short name8 EMBL Total

Person-months9 0.1 (0) 0.1 (0) Preparations have begun for the first MAX-INF2 Integration Workshop, which will be held at EMBL Hamburg on 27th-28th February 2006. Discussions took place during Year 1 between the coordinator and representatives of EMBL Hamburg about the content and timing of this meeting. 1.3.4. Activity N4: Web site Participant number10 2

Participant short name11 SRS Total

Person-months12 0.1 (0) 0.1 (0)

The objective of Activity N4 is to act as a repository for network-related documents, and to provide the community with a single point of reference for schools and workshops organized by the network. A similar web site was created for the first MAX-INF network, and for the sake of continuity it was decided to extend this site rather than create a new one (http://www.ccp4.ac.uk/maxinf). Specifically, there were updates to the introductory text, to the contact information and to the logo, and the contract proposal and participant list for MAX-INF2 were added. A copy of the contract with its Annexes I and II are also available. The minutes of the first MAX-INF2 coordination meeting were added for the benefit of the network participants. The web site provides a list of schools and workshops that have been funded by MAX-INF2, both those that are planned and those that have taken place. Entries provided brief details of each workshop, and a link to the primary workshop web site. This list has been kept up-to-date for MAX-INF2. One of these workshops was the Molecular Modelling for Macromolecular Crystallography workshop held at Diamond in October 2005. Talks and

7 Lead participant first 8 Use the same contractor short names and numbers indicated in the table “list of participants” in Annex I of


additional staff only. 10 Lead participant first 11 Use the same contractor short names and numbers indicated in the table “list of participants” in Annex I of

your contract. 12 AC contractors must include both the total estimated human effort (including permanent staff) and, in

brackets, additional staff only.

A. ACTIVITY REPORT


associated material from this meeting have been included on the MAX-INF2 web site (and are not held anywhere else). 1.4 Update of the non-confidential Project information

Reporting Period: AR1 Project Web-site address: http://www.ccp4.ac.uk/maxinf Project Objectives: The first main goal of MAX-INF2 is to achieve long-term integration of the infrastructure for macromolecular crystallography (MX) in Europe. The network acts to disseminate knowledge between the infrastructure providers concerning the development of the hardware and software required by the MX community. Crystal structure determination of proteins, nucleic acids and their complexes relies heavily on research infrastructures such as synchrotron radiation (SR) facilities, as well as hardware and software development projects. The network will have a forum for identifying areas of cooperation centred around the exploitation of SR, hardware and software development in life science crystallography. It will also extend the model for software coordination currently centred on the highly successful British CCP4 project to a European base. MAX-INF2 brings together large-scale facilities, hardware and software developers, academic and commercial users to reflect the current requirements of high throughput macromolecular structure determination in the post-genomic era.

A second, tightly integrated approach, will be to organise workshops and schools for the European MX user community, in particular for young scientists (Ph.D. students and postdocs). MX is essentially a physical science, and since more and more research groups with a biological or medical background are embarking on crystallography experiments, the need for teaching the basic principles of protein crystallography, e.g. X-ray data collection and structure determination, analysis and exploitation, is growing. This will ensure the development of good common practice in the MX user community. Project Achievements: The integration goals of MAX-INF2 are to be achieved primarily through Integration Workshops which will promote a culture of cooperation between researchers at the different infrastructure providers involved, as well as software and hardware developers working for and around these facilities. The first of these workshops was due to take place in Year 2, and it will be held on 27-28 February 2006 at EMBL Hamburg. The coordinator has been consulting with researchers at EMBL Hamburg in the planning of this meeting. The activities of MAX-INF2 have thus focused mainly on the dissemination of the latest knowledge through organisation of Practical Workshops and Theoretical Schools. Six Practical Workshops have taken place during Year 1, somewhat more than was originally projected. The subject areas were: "Future directions in Macro-Molecular Crystallography", "Exploiting Anomalous Scattering in Macromolecule Structure Determination", "Crystallographic Computing", "Membrane proteins, the rocky road from gene to structure", "Molecular modelling for macromolecular crystallographers" and "Macromolecular Crystallography: From measurements to model". These Practical Workshops have all been a great success and have met with a very positive response from the students involved. The Theoretical School was planned for Year 2, and extensive preparatory activities have taken place during Year 1. The School will take place at Centro del Casino, Como, Italy, on 21-25 May 2006. A full list of speakers has been prepared and the administrative side of the meeting is in place. A web site for registration will be opened at the end of January.

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2. List of deliverables

Activity Deliverable No

Deliverable Name Delivered by Contractor(s)

Planned (in months)

Achieved (in months)

N1 1 First Coordination Meeting

1 2 2

N2 1 SOLEIL workshop 7 1 1 2 ESRF workshop 4 7 7 3 Siena workshop 14 9 9 4 ITQB workshop 15 10 10 5 Diamond workshop 8 11 11 6 EMBL Hamburg

workshop 3 12 12

N4 1 Functioning web site 2 1 1

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3. Use and dissemination of knowledge The situation regarding dissemination of knowledge in MAX-INF2 is somewhat special, since a major part of the activities of the network consists of organising workshops and schools, and our deliverables are thus in themselves tools for the dissemination of knowledge. Therefore the fact that six workshops have been held and that the organisation of the first theoretical school in 2006 is well-established can be considered good progress in this area. However we have taken additional steps to ensure that knowledge from the network is spread as widely as possible. All the practical workshops are both announced and logged on the network's Web page (http://www.ccp4.ac.uk/maxinf). Where possible and relevant, presentations made at the workshops have been placed on the same site. The workshops are always announced on the electronic bulletin boards relevant for the MX community, which ensures spreading of the information to thousands of potential participants and future infrastructure stakeholders. The Scientific Advisory Group, consisting of representatives of influential MX user laboratories outside of MAX-INF2, will be invited to the first Integration Workshop and second Coordination Meeting. We hope that they will thus spread information about the work of MAX-INF2, primarily by encouraging members of their laboratories to attend the Practical Workshops and Theoretical Schools. We also welcome their input on the future direction of the network. The plan for use and dissemination of knowledge as outlined in Annex I of the contract still stands as originally written and does not need to be updated at this point.

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Annexes

Annex 1 – Summaries and main conclusions of the General Meetings (section 1.2) The first general meeting of MAX-INF2 was held at Reading University, UK on 8th January 2005. The coordinator and representatives of 7 other partners were present. The low turnout can be explained by the ad-hoc nature of the meeting. The contract had just been approved and there was no time to advertise the meeting several months in advance as described in the contract. However the coordinator felt that there was a need to disseminate information about the way that the network would be run, as this differed in many ways from MAX-INF, this network's predecessor in FP5.

The budget was presented. The coordinator explained the way that financial issues would be handled for a Coordination Action for Infrastructures under FP6. In particular the issue of "cross-invoicing" was discussed at length, as well as the need for costs to be generated by the partners themselves and not reimbursed by another partner. Workshops were presented for approval by the assembly. Three of these had already been identified in Annex I and a further 5 were presented and approved for funding. Workshop 7 has not yet taken place and Workshop 8 falls within the second reporting period; thus only six were funded during the first reporting period. The full minutes follow on the next page.

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Minutes of 1st MAX-INF2 Coordination Meeting, 8th January 2005, University of Reading, UK.

Attendees: Derek Logan Lund University (chairman, acting coordinator) Martyn Winn Daresbury Laboratory Andrea Schmidt EMBL Hamburg Raimond Ravelli EMBL Grenoble Phil Evans MRC LMB Margarida Archer ITQB Andrew Thompson SOLEIL David Hall ESRF Harry Powell MRC LMB 1. Presentation and discussion of budget

Derek Logan distributed the final version of the indicative budget. In particular the issue of cross-invoicing and the consequent requirement for participants to generate their own costs and pay them from their own allocations was explained. The necessity for auditing and its frequency were also discussed.

2. Workshops planned for the first 18 months Those already indicated in Annex I: Workshop 1: Future directions in synchrotron radiation bio-crystallography. Synchrotron SOLEIL, St. Aubin, France, 13th-14th December 2004. Organisers: Andrew Thompson, Roger Fourme, Eric Girard, Pierre Legrand (SOLEIL). This workshop has already been held.

Workshop 2: Membrane proteins: the rocky road from gene to crystal. 19–24 September, 2005, Oeiras, Portugal. Organisers participant IQTB, Lisbon and Prof. So Iwata, Imperial College, London, UK.

Workshop 3: Exploiting anomalous scattering in macromolecular structure determination. 14th-19th June 2005, ESRF, Grenoble, France. Organisers Bill Shepard (ESRF) and Hassan Berhali (EMBL Grenoble).

Further workshops:

Workshop 4: "Macromolecular crystallography, from measurements to model"

EMBL Hamburg, October–November 2005. Organisers: Dr. Victor Lamzin (EMBL Hamburg). Workshop 5: Computing workshop in conjunction with IUCr meeting in Florence. Organiser Dr. Harry Powell (MRC LMB)

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Workshop 6: Modelling at Diamond. Organiser Katherine McAuley.

Workshop 7: Robotic approaches to crystallisation trials and crystal visualisation, Autumn 2005. Organiser: Tony Fordham-Skelton, Daresbury. A workshop to compare the various approaches to crystallisation trials at both synchrotrons and university labs. There would be particular emphasis on robotic hardware, reproducibility, tracking of samples, management of images. Each delegate would describe their own set-ups and experiences. Who: Representative of synchrotrons, university labs, and robot manufacturers. Maybe 20 - 30 people.

Workshop 8: SLS Practical Course on "Advanced Data Collection Techniques using 3rd Generation Synchrotron Facilities", SLS, 7th-12th March 2006. A preliminary programme was presented to the chairman at the end of the meeting. 16 students.

The meeting participants agreed in principle to fund these meetings from the MAX-INF2 budget, but detailed programmes and the amount requested from MAX-INF2 for workshops 4–8 (the block allocation is 16 kEuro per workshop but less can of course be requested) will have to be sent to the coordinator before funding can finally be approved.

3. Organizer of first Integration Workshop

No-one volunteered directly to organize this but Andrea Schmidt promised to ask Victor Lamzin if EMBL Hamburg would be interested.

Annex 2 – CD-ROM with the deliverables produced during the reporting period (section 2)

16 Contract [RICA-CT-200X-XXXXXX] Annual Report

B. MANAGEMENT REPORT (FINANCIAL INFORMATION)

1. Justification of the resources deployed

[Provide, for each contractor, the table “Justification of resources deployed during the reporting period”( Appendix 1)]

Justification of resources deployed during reporting period

Contract N° 505977 Project acronym MAX-INF2

Participant N° 1 Participant short name MAX-lab

Total effort in person-months (1) 1.25 (1.25)

Cost category Actual direct eligible costs (€)

Personnel cost 0

Postage 498.02

Total effort in person-months (1)


Personnel cost 0

Travel 272.06

Total effort in person-months (1) 0.1 (0.1)


Justification of costsdescription of expenditure and link to the specific work carried out (e.g. tasks, work packages, …)

Personnel cost 0




Personnel cost 0




Personnel cost 0


Justification of costs

description of expenditure and link to the specific work carried out (e.g. tasks, work packages, …)

Personnel cost

…

Total direct eligible costs 770.08

Total indirect costs 154.02

Total costs (2) 924.10 Global estimate of the total costs for AC contractors (not only the eligible costs) 924.10 (AC) + 8000 (salary) = 8924.10

Justify any deviations with respect to the planned budget

No cost has yet been claimed for the adminstrator's salary under "Management", due to an oversight. This will be rectifiedin reporting period 2MAX-lab appears to be significantly under the projected budget for the first 18 months but this is because the Theoretical School hasyet to take place, but will do so in May 2006.

(1) AC contractors must include both the total estimated human effort (including permanent staff) and, in brackets, additional staff only.(2) Totals should correspond to the respective figures on FORM C - Financial Statement


Activity N1: Theoretical Schools

Activity N2: Practical workshops

Activity N3: Coordination meetings

Activity 1: management of the CA


Travel to first Coordination meeting January 2005

Postage by courier of documents to various partners

Activity 2: Coordination meetings

Activity N4: Web site




Participant N° 3 Participant short name EMBL



Personnel cost

…



Personnel cost

…



Justification of costsdescription of expenditure and link to the specific work

carried out (e.g. tasks, work packages, …)

Personnel cost

…

Total effort in person-months (1) 1




Personnel cost

Travel and subsistence 13,043.08 Travel and subsistence for speakers and participants in M2M workshop

…





Personnel cost

…




Personnel cost

Total direct eligible costs 13,043.08

Total indirect costs 2,608.61

Total costs (2) 15,651.69 Global estimate of the total costs for AC contractors (not only the eligible costs) 24 000


EMBL may appear to be under budget, but it has not yet held the Coordination Meeting and Integration Workshop which itreceived prepayment for. These will be held in February 2006.













Participant N° 4 Participant short name ESRF



Personnel cost

…



Personnel cost

…



Personnel cost

…

Total effort in person-months (1) 2 (0)


Travel 9,500.00 Travel expenses of workshop participants

Meals/ coffee breaks 5,100.00 Catering expenses for workshop participants



Personnel cost

…


Personnel cost



Total costs (2) 17,520.00 Global estimate of the total costs for AC contractors (not only the eligible costs) 44520 [17520 (AC) + 27000 (other)]



















Participant N° 7 Participant short name SOLEIL



Personnel cost 0

Travel and subsistence 4370.51



Personnel cost 0




Personnel cost 0




Personnel cost 0




Personnel cost 0




Personnel cost

…



Total costs (2) 5244.61 Global estimate of the total costs for AC contractors (not only the eligible costs)






Reimbursement of travel to invited speakers for workshop in December 2004









Participant N° 8 Participant short name Diamond



Personnel cost 0

Travel and subsistence 4855.58



Personnel cost 0





Personnel cost 0





Personnel cost 0





Personnel cost 0




Personnel cost

…



Total costs (2) 4855.58 Global estimate of the total costs for AC contractors (not only the eligible costs)











Travel and subsistence for participants in MM4MX workshop




Participant N° 14 Participant short name MRC-LMB



Personnel cost

…



Personnel cost

…





Personnel cost

…





Personnel cost 0

Accommodation and meals 3,031.73 Accommodation and meals for EU non-MAX-INF2 speakers

Student bursaries 5,623.18 Contribution to travel and subsistence for selected EU student attendees

Bank charges 198.69 Bank charges (transfer GBP to Euro)





Personnel cost

…




Personnel cost



Total costs (2) 10624.32 Global estimate of the total costs for AC contractors (not only the eligible costs) N/A














Participant N° 15 Participant short name ITQB



Personnel cost

…



Personnel cost

Accomodation and living expenses 400.00



Personnel cost

…

Total effort in person-months (1) 2,6 + (4,45)


Organising costs 4,964.45 Local organising committe, computing costs and some consumables (paper, mail, toner, ...)

Accomodation and living expenses 5,859.20 Travel tutors and accommodations/lunches for all the participants

Pratical Laboratorial sessions 7,512.34 Several lab consumables



Personnel cost

…



Personnel cost



Total costs (2) 22,402.96 Global estimate of the total costs for AC contractors (not only the eligible costs) =22.402,96 (AC) + 23.020,52 (others) =45.423,48










Meeting held in January Profª. Margarida Archer







FP6 Research Infrastructures 17 Contract [RII3-CT-200X-XXXXXX] Integrated Infrastructure Initiative Annual Report

2. Forms C - Financial Statements [Provide, for each contractor, the Form C - Financial Statements13 (Appendix 2). Audit certificates must be submitted with the Forms C if required for this period in Article 7.2 of the contract14.]

13 For instructions on the correct completion of the Form C see the FP6 Financial Guidelines on Cordis: http://www.cordis.lu/fp6/find-doc.htm#modelcontracts 14 For more detailed information on Audit Certificates see the FP6 Financial Guidelines on Cordis: http://www.cordis.lu/fp6/find-doc.htm#modelcontracts

Third Party 1 (Y1)Third Party 2 (Y2)Third Party 3 (Y3)Third Party 4 (Y4)

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Direct costs 770.08 770.08

Of which subcontracting

Indirect costs 154.02 154.02Adjustments to previous period(s)

Total costs 924.10 924.10

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Legal TypeContractors's legal name Lund University

GOVDr. Marjolein Thunnissen

ACCost model used (AC/FC or FCF)

00 46 46 222 4692Contact PersonTelecopy

Period from 1/12/04

If necessary add another Form C

Please complete only the activity covered by the relevant instrument (and type of action) indicated above and as mentioned in Article II.25 and/orin Annexes I and III of the contract.If you are a contractor using the additional cost model (AC):- indicate only your additional eligible costs, except for Management of the Consortium Activity for which you may indicate your full eligible costs;- do not declare eligible direct additional costs specifically covered by contributions from third parties as mentioned in Articles II.20 and II.23.aand b of the contract.If you are a contractor using a full cost model (FC/FCF), indicate your full eligible costsThe costs declared should distinguish between direct and indirect costsIf necessary, adjustments to previous period(s) may be included where appropriate.

2- Declaration of eligible costs (in €)

Type of Activity

(A’) (B’) (C’) (D’)

Research and Technological Development /

Innovation

Demonstration

Form C - Model of Financial Statement per Activity for a Coordination Action for Infrastructures(to be completed by each contractor)

MAX-INF2Project Title (or Acronym)

Type of instrument Coordination Action

1- Resources (Third party(ies)) Are there any resources made available on the basis of a prior agreement with third parties identified in Annex I of the contract? (Yes / No) No

If Yes, please provide the following informationLegal nameLegal name

Type of ActivityResearch and Technological Development /

Innovation

Demonstration Training Management of the Consortium

Other Specific Activities:

CoordinationTotal

(A) (F) = (A)+(B)+(C)+(D)+(E)

3- Declaration of receipts (in €)

(B) (C) (D) (E)

If you are a contractor using the additional cost model (AC), indicate only receipts covered by Article II.23.c of the contract.

If you are a contractor using a full cost model (FC/FCF), indicate receipts covered by Article II.23 of the contract.

(E’) (F’) = (A)’+(B’)+(C’)+(D’)

Management of the Consortium

Other Specific Activities TotalTraining

+(E’)

Legal name

[email protected]

Indirect costs (Real or Flat Rate of 20% of Direct costs, except subcontracting)

Flat rate of 20% of Direct Costs, except

subcontracting

To 30/11/05

Legal name Cost model used

Cost model usedCost model used

Cost model used

Type of Action (if necessary) Infrastructures

Contract n° 505977

TelephoneE-mail

00 46 46 222 4584

From -to

NO

YES

Y4 : Legal name of the audit firm Cost of the certificate

4- Declaration of interest generated by the pre-financing (in €)

30/11/07

Did the pre-financing (advance) you received by the Commission for this period earn interest? (Yes / No) YesIf yes, please indicate the amount (in €) 881.26

5- Request of FP6 Financial Contribution (in €)

6- Audit certificates

If Yes, does this(those) audit certificate(s) cover only this Financial Statement per Activity? (Yes / No)

According to the contract, does this Financial Statement need an audit certificate (or several in case of Third party(ies)) delivered by independent auditor(s)? (Yes / No) No

If necessary add another Form C. Total (Z) = (X) + (Ys)

Audit certificate(s) of the third party(ies) (Ys) (if necessary)

Y2 : Legal name of the audit firm Cost of the certificateCost of the certificateY1 : Legal name of the audit firm

Reminders: The cost of an audit certificate is included in the costs declared under the activity “Management of the Consortium”.The required audit certificate(s) is (are) attached to this Financial Statement

7- Conversion rates

Contractor- Conversion rate of the date of incurred actual costs? (YES / NO)

Costs incurred in currencies other than EURO shall be reported in EURO.

Please mention the conversion rate used (only one choice is possible) – Please note that the same principle applies for receipts.

- Conversion rate of the first day of the first month following the period covered by this Financial Statement? (YES/NO)

Third Party(ies) (if necessary)Third Party 1 (Y1)

- Conversion rate of the date of incurred actual costs? (YES / NO)



Third Party 2 (Y2)



Audit certificate of the contractor (X)

If No, what are the periods covered by this(those) audit certificate(s) ? 1/12/04

For this period, the FP6 Community financial contribution requested is equal to ( amount in €) 924.10

To be completed only by the coordinator.

What is the total cost of this(those) audit certificate(s) (in €) per independent auditor(s) ?

Legal name of the audit firm Cost of the certificate

Third Party 3 (Y3)

Third Party 4 (Y4)


We certify that:

If necessary add another Form C.

8- Contractor’s Certificate



for the work

- the receipts declared above are directly related to the resources used to reach the objectives of the project ;

- the costs declared above fall within the definition of eligible costs specified in Articles II.19, II.20, II.21, II.22 and II.25 of the contract, and, ifrelevant, in Annex III and Article 9 (special clauses) of the contract ;


- the costs declared above are directly related to the resources used to reach the objectives of the project ;

Signature

- the receipts declared above fall within the definition of receipts specified in Article II.23 of the contract ;- the interest generated by the pre-financing declared above falls within the definition of Article II.27 of the contract ;- the necessary adjustments, especially to costs reported in previous Financial Statement(s) per Activity, have been incorporated in the aboveStatement ;- the above information declared is complete and true ;

- there is full supporting documentation to justify the information hereby declared. It will be made available at the request of the Commission andin the event of an audit by the Commission and/or by the Court of Auditors and/or their authorised representatives.

Contractor’s Stamp

Name of the Person responsible Name of the duly authorised

Signature

Financial OfficerDr. Marjolein Thunnissen Prof. Olov Sterner

Date Date12/1/06 12/1/06


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Direct costs 13,043.08 13,043.08


Indirect costs 2,608.61 2,608.61Adjustments to previous period(s)

Total costs 15,651.69 15,651.69

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Cost model used


Contract n° 505977

TelephoneE-mail

49 6221 387 427


Legal name

[email protected]


Flat rate of 20% of Direct Costs, except subcontracting

To 31/11/2005


+(E’)



(E’) (F’) = (A)’+(B’)+(C’)+(D’)




(B) (C) (D) (E)

Total

(A) (F) = (A)+(B)+(C)+(D)+(E)


Innovation



Coordination


1- Resources (Third party(ies)) Are there any resources made available on the basis of a prior agreement with third parties identified in Annex I of the contract? (Yes / No) NO





Type of Activity

(A’) (B’) (C’) (D’)


Innovation

Demonstration

Period from 1/12/04


Please complete only the activity covered by the relevant instrument (and type of action) indicated above and as mentioned in Article II.25 and/or inAnnexes I and III of the contract.If you are a contractor using the additional cost model (AC):- indicate only your additional eligible costs, except for Management of the Consortium Activity for which you may indicate your full eligible costs;- do not declare eligible direct additional costs specifically covered by contributions from third parties as mentioned in Articles II.20 and II.23.a and bof the contract.If you are a contractor using a full cost model (FC/FCF), indicate your full eligible costsThe costs declared should distinguish between direct and indirect costsIf necessary, adjustments to previous period(s) may be included where appropriate.

Dale Dean


49 6221 387 575Contact PersonTelecopy

Legal TypeContractors's legal name European Molecular Biology Laboratory

International Institution

From -to

YES

Signature

Financial Officer29.12.2005 29.12.2005

Date DateVictor Lamzin Dale Dean

Signature


- there is full supporting documentation to justify the information hereby declared. It will be made available at the request of the Commission and inthe event of an audit by the Commission and/or by the Court of Auditors and/or their authorised representatives.


Name of the Person responsible Name of the duly authorisedfor the work


- the costs declared above fall within the definition of eligible costs specified in Articles II.19, II.20, II.21, II.22 and II.25 of the contract, and, if relevant,in Annex III and Article 9 (special clauses) of the contract ;



Third Party 3 (Y3)

Third Party 4 (Y4)


We certify that:







For this period, the FP6 Community financial contribution requested is equal to ( amount in €) 15,651.69







Third Party 2 (Y2)








Reminders: The cost of an audit certificate is included in the costs declared under the activity “Management of the Consortium”.The required audit certificate (s) is(are) attached to this Financial Statement

7- Conversion rates





According to the contract, does this Financial Statement need an audit certificate (or several in case of Third party(ies)) delivered by independent auditor(s)? (Yes / No) NO

31/11/2007

Did the pre-financing (advance) you received by the Commission for this period earn interest? (Yes / No)If yes, please indicate the amount (in €)





Third Party 1 (Y1)

Third Party 2 (Y2)

Third Party 3 (Y3)

Third Party 4 (Y4)

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Direct costs 14600 14600


Indirect costs 2920 2920

Adjustments to previous period(s)Total costs 17520 17520

+(E’)



(E’) (F’) = (A)’+(B’)+(C’)+(D’)


Other Specific Activities Total

(F) = (A)+(B)+(C)+(D)+(E)


(B) (C) (D) (E)


Innovation



CoordinationTotal

(A)

do not declare eligible direct additional costs specifically covered by contributions from third parties as mentioned in Articles II.20 andII.23.a and b of the contract.

If you are a contractor using a full cost model (FC/FCF), indicate your full eligible costsThe costs declared should distinguish between direct and indirect costsIf necessary, adjustments to previous period(s) may be included where appropriate

Legal name

Cost model used

Cost model used

Legal name

If Yes, please provide the following information


1- Resources (Third party(ies))

Are there any resources made available on the basis of a prior agreement with third parties identified in Annex I of the contract? (Yes / No) No

Form C - Model of Financial Statement per Activity for a Coordination Action(to be completed by each contractor)

MAX-INF2 505977Project Title (or Acronym) Contract n°

Type of instrument Coordination Action Type of Action (if necessary)

Type of Activity

(A’) (B’) (C’) (D’)


Innovation

Demonstration Training

If you are a contractor using the additional cost model (AC):

- indicate only your additional eligible costs, except for Management of the Consortium Activity for which you may indicate your fulleligible costs;

Cost model usedLegal nameIf necessary add another Form C

Please complete only the activity covered by the relevant instrument (and type of action) indicated above and as mentioned in ArticleII.25 and/or in Annexes I and III of the contract.


Period from 1/12/04 TO 30/11/05


Helmut KRECH

AC Flat rate of 20% of Direct Costs, except subcontractingCost model used (AC/FC or FCF)

(33) 476 88 20 06(33) 476 88 28 06 E-mail [email protected]

N.A

Legal Type

Contractors's legal name European Synchrotron Radiation Facility

PrivateContact Person TelephoneTelecopy

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From -to

Signature

Financial OfficerGordon LEONARD Jean-Louis PLANTIER

Date Date20/12/05 20/12/05

Signature

- the receipts declared above fall within the definition of receipts specified in Article II.23 of the contract ;- the interest generated by the pre-financing declared above falls within the definition of Article II.27 of the contract ;- the necessary adjustments, especially to costs reported in previous Financial Statement(s) per Activity, have been incorporated in theabove Statement ;- the above information declared is complete and true ;

- there is full supporting documentation to justify the information hereby declared. It will be made available at the request of theCommission and in the event of an audit by the Commission and/or by the Court of Auditors and/or their authorised representatives.



Total (Z) = (X) + (Ys)


- the costs declared above fall within the definition of eligible costs specified in Articles II.19, II.20, II.21, II.22 and II.25 of the contract,and, if relevant, in Annex III and Article 9 (special clauses) of the contract ;


Third Party 3 (Y3)

Third Party 4 (Y4)


We certify that:




For this period, the FP6 Community financial contribution requested is equal to ( amount in €)17520









Third Party 2 (Y2)







Please mention the conversion rate used (only one choice is possible) – Please note that the same principle applies forreceipts.

Reminders: The cost of an audit certificate is included in the costs declared under the activity “Management of the Consortium”.The required auditcertificate (s) is (are) attached to this Financial Statement

7- Conversion rates


Legal name of the auditfirm

Cost of the certificate

Audit certificate(s) of the third party(ies) (Ys) (if necessary)Y1 : Legal name of the audit

firm Cost of the certificate


If No, what are the periods covered by this(those) audit certificate(s) ?









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Indirect costs

Adjustments to previous period(s)

Total costs 0

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Cost model used


Contract n° 505977

TelephoneE-mail

**43/1/4277/52203


Legal name

[email protected]

Indirect costs (Real or Flat Rate of 20% of Direct costs, except subcontracting) Flat rate

31/11/2005


+(E’)



(E’) (F’) = (A)’+(B’)+(C’)+(D’)




(B) (C) (D) (E)

Total

(A) (F) = (A)+(B)+(C)+(D)+(E)


Innovation



Coordination







Type of Activity

(A’) (B’) (C’) (D’)


Innovation

Demonstration

Period from 1/12/04



Kristina Djinovic-Carugo


Contact PersonTelecopy

Legal TypeContractors's legal name University of Vienna

From -to

Signature

Financial OfficerProf.Kristina Djinovic-Carugo Reg.Rat Johann Höhlmüller

Date Date8/1/06 8/1/06

Signature









Third Party 3 (Y3)

Third Party 4 (Y4)


We certify that:







For this period, the FP6 Community financial contribution requested is equal to ( amount in €)







Third Party 2 (Y2)









7- Conversion rates




If Yes, does this(those) audit certificate(s) cover only this Financial Statement per Activity? (Yes / No)No

According to the contract, does this Financial Statement need an audit certificate (or several in case of Third party(ies)) delivered by independent auditor(s)? (Yes / No) Yes

31/11/2007

Did the pre-financing (advance) you received by the Commission for this period earn interest? (Yes / No) NoIf yes, please indicate the amount (in €)






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Indirect costs 0 0Adjustments to previous period(s)

Total costs 0 0

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Cost model used


Contract n° 505977

TelephoneE-mail

+41 56 310 45 33


Legal name

[email protected]

Indirect costs (Real or Flat Rate of 20% of Direct costs, except subcontracting) 20%

To 30/11/05


+(E’)



(E’) (F’) = (A)’+(B’)+(C’)+(D’)




(B) (C) (D) (E)

Total

(A) (F) = (A)+(B)+(C)+(D)+(E)


Innovation



Coordination







Type of Activity

(A’) (B’) (C’) (D’)


Innovation

Demonstration

Period from 1/12/04



Clemens Schulze-Briese

FCCost model used (AC/FC or FCF)


Legal TypeContractors's legal name Paul Scherrer Institut

Gov

From -to

Signature

Financial OfficerClemens Schulze-Briese Angela Vatter

Date Date4/1/05 4/1/05

Signature









Third Party 3 (Y3)

Third Party 4 (Y4)


We certify that:







For this period, the FP6 Community financial contribution requested is equal to ( amount in €) 0







Third Party 2 (Y2)









7- Conversion rates











Third Party 1 (Y1)

Third Party 2 (Y2)

Third Party 3 (Y3)

Third Party 4 (Y4)

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Direct costs 4370.51 4370.51


Indirect costs 874.10 874.10

Adjustments to previous period(s)Total costs 5244.61 5244.61

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(E’)

Legal name



N.A

TelephoneE-mail

Legal name

Telecopy

Cost model used (AC/FC or FCF)

Period from TO


1/12/04

FCF

30/11/05

01 69 35 94 5201 69 35 95 [email protected]

SYNCHROTRON SOLEIL

PRIVATE COMPANYNIGEN MURIEL

Contractors's legal name

Legal TypeContact Person

Total

(F’) = (A)’+(B’)+(C’)+(D’)

(D) (E)

(C’)

Type of Activity


(D’)


Other Specific Activities


Innovation

(A)

Demonstration Total

(F) = (A)+(B)+(C)+(D)+(E)


Innovation

flat rate of 20%

1- Resources (Third party(ies))

If Yes, please provide the following information

(to be completed by each contractor)

Form C - Model of Financial Statement per Activity for an Integrated Project

MAX-INF2 505977

Type of Action (if necessary)

Contract n°

Integrated ProjectType of instrument

Project Title (or Acronym)

NOAre there any resources made available on the basis of a prior agreement with third parties identified in Annex I of the contract? (Yes / No)


Legal name

Cost model used

Cost model used

Cost model used

(C)


If you are a contractor using a full cost model (FC/FCF), indicate your full eligible costsThe costs declared should distinguish between direct and indirect costs

Please complete only the activity covered by the relevant instrument (and type of action) indicated above and as mentioned in Article II.25and/or in Annexes I and III of the contract.

- indicate only your additional eligible costs, except for Management of the Consortium Activity for which you may indicate your full eligiblecosts;

do not declare eligible direct additional costs specifically covered by contributions from third parties as mentioned in Articles II.20 and II.23.aand b of the contract.

If you are a contractor using the additional cost model (AC):

Demonstration

(B’)

If necessary, adjustments to previous period(s) may be included where appropriate

(B)

Type of Activity

Training



(A’)

Training

+(E’)


Total receipts

From -to

NO

NO

5/1/05

Christian BOZECDate

Signature

Andrew THOMPSON

5/1/05Signature

Date

- the necessary adjustments, especially to costs reported in previous Financial Statement(s) per Activity, have been incorporated in the aboveStatement ;- the above information declared is complete and true ;

- there is full supporting documentation to justify the information hereby declared. It will be made available at the request of the Commissionand in the event of an audit by the Commission and/or by the Court of Auditors and/or their authorised representatives.


Name of the Person responsible Name of the duly authorisedfor the work Financial Officer



- the receipts declared above fall within the definition of receipts specified in Article II.23 of the contract ;- the interest generated by the pre-financing declared above falls within the definition of Article II.27 of the contract ;


8- Contractor’s CertificateWe certify that:- the costs declared above are directly related to the resources used to reach the objectives of the project ;


- Conversion rate of the date of incurred actual costs? (YES / NO) - Conversion rate of the first day of the first month following the period covered by this Financial Statement? (YES/NO)


Third Party 4 (Y4)

Third Party 3 (Y3)



Third Party 1 (Y1)Third Party(ies) (if necessary)

The cost of an audit certificate is included in the costs declared under the activity “Management of the Consortium”.The required auditcertificate (s) is (are) attached to this Financial Statement


Total (Z) = (X) + (Ys)Reminders:



Contractor


Third Party 2 (Y2)



Legal name of the audit firm



According to the contract, does this Financial Statement need an audit certificate (or several in case of Third party(ies)) delivered by independent auditor(s)? (Yes / No)


Did the pre-financing (advance) you received by the Commission for this period earn interest? (Yes / No) NO


For this period, the FP6 Community financial contribution resuested is equal to ( amount in €)5,245 €

If yes, please indicate the amount (in €)

4- Declaration of interest generated by the pre-financing (in €)To be completed only by the coordinator.

Y1 : Legal name of the audit firm






7- Conversion rates






NO


Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Direct costs 0 0 0 0 0 0

Of which subcontracting 0 0 0 0 0 0

Indirect costs 0 0 0 0 0 0Adjustments to previous period(s) 0 0 0 0 0 0

Total costs 0 0 0 0 0 0

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Total receipts 0 0

Cost model used


Contract n° 505977

TelephoneE-mail

+49-30-63924974


Legal name

[email protected]



subcontracting

To 31/11/2005


+(E’)



(E’) (F’) = (A)’+(B’)+(C’)+(D’)




(B) (C) (D) (E)

Total

(A) (F) = (A)+(B)+(C)+(D)+(E)


Innovation



Coordination







Type of Activity

(A’) (B’) (C’) (D’)


Innovation

Demonstration

Period from 1/12/04



Dr. Uwe Mueller


+49-30-63924975Contact PersonTelecopy

Legal TypeContractors's legal name Freie Universität Berlin

Govermental

From -to

Signature

Financial OfficerDr. Uwe Mueller Christine Barker

Date Date

Signature









Third Party 3 (Y3)

Third Party 4 (Y4)


We certify that:














Third Party 2 (Y2)









7- Conversion rates






31/11/2007

Did the pre-financing (advance) you received by the Commission for this period earn interest? (Yes / No) NoIf yes, please indicate the amount (in €)






Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Direct costs 0 0



Total costs 0 0

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Total receipts 0

Cost model used


Contract n° 505977

TelephoneE-mail

00 31 71 527 4302


Legal name

[email protected]


Flat rate of 20% of Direct Costs, except subcontracting

To 30/11/05


+(E’)



(E’) (F’) = (A)’+(B’)+(C’)+(D’)




(B) (C) (D) (E)

Total

(A) (F) = (A)+(B)+(C)+(D)+(E)


Innovation



Coordination








Type of Activity

(A’) (B’) (C’) (D’)


Innovation

Demonstration

Period from 1/12/04


Please complete only the activity covered by the relevant instrument (and type of action) indicated above and as mentioned in Article II.25 and/or inAnnexes I and III of the contract.If you are a contractor using the additional cost model (AC):- indicate only your additional eligible costs, except for Management of the Consortium Activity for which you may indicate your full eligible costs;- do not declare eligible direct additional costs specifically covered by contributions from third parties as mentioned in Articles II.20 and II.23.a and b ofthe contract.If you are a contractor using a full cost model (FC/FCF), indicate your full eligible costsThe costs declared should distinguish between direct and indirect costsIf necessary, adjustments to previous period(s) may be included where appropriate.

H.B.L. Kuiperbak


00 31 71 527 4357Contact PersonTelecopy

Legal TypeContractors's legal name Universiteit Leiden

GOV

From -to

Signature

Financial OfficerProf. Jan-Pieter Abrahams T. Brouwer

Date Date9/1/06 9/1/06

Signature

- the receipts declared above fall within the definition of receipts specified in Article II.23 of the contract ;- the interest generated by the pre-financing declared above falls within the definition of Article II.27 of the contract ;- the necessary adjustments, especially to costs reported in previous Financial Statement(s) per Activity, have been incorporated in the above Statement;- the above information declared is complete and true ;

- there is full supporting documentation to justify the information hereby declared. It will be made available at the request of the Commission and in theevent of an audit by the Commission and/or by the Court of Auditors and/or their authorised representatives.




- the costs declared above fall within the definition of eligible costs specified in Articles II.19, II.20, II.21, II.22 and II.25 of the contract, and, if relevant, inAnnex III and Article 9 (special clauses) of the contract ;



Third Party 3 (Y3)

Third Party 4 (Y4)


We certify that:














Third Party 2 (Y2)








Reminders: The cost of an audit certificate is included in the costs declared under the activity “Management of the Consortium”.The required audit certificate (s) is(are) attached to this Financial Statement

7- Conversion rates











Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Direct costs 0 0



Total costs 0 0

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Total receipts

Cost model used


Contract n° 505977

TelephoneE-mail

0049 551 39 9795


Legal name


To 30/11/05


+(E’)



(E’) (F’) = (A)’+(B’)+(C’)+(D’)




(B) (C) (D) (E)

Total

(A) (F) = (A)+(B)+(C)+(D)+(E)


Innovation



Coordination







Type of Activity

(A’) (B’) (C’) (D’)


Innovation

Demonstration

Period from 1/12/04



Dr. Dorothea Mey


0049 551 39 3797Contact PersonTelecopy

Legal TypeContractors's legal name Georg-August-Universität Göttingen

GOV

From -to

Signature

Financial Officer Prof. G. M. Sheldrick, PhD Dr. D. Mey

Date Date

Signature









Third Party 3 (Y3)

Third Party 4 (Y4)


We certify that:














Third Party 2 (Y2)









7- Conversion rates






30/11/07







Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Direct costs 0 0


Indirect costs 0Adjustments to previous period(s)

Total costs 0 0 0 0

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Total receipts 0

Legal TypeContractors's legal name CERBM GIE

ResearchA. PODJARNY



Period from 1/12/04




Type of Activity

(A’) (B’) (C’) (D’)


Innovation

Demonstration




1- Resources (Third party(ies)) Are there any resources made available on the basis of a prior agreement with third parties identified in Annex I of the contract? (Yes / No) NO



Innovation



CoordinationTotal

(A) (F) = (A)+(B)+(C)+(D)+(E)


(B) (C) (D) (E)



(E’) (F’) = (A)’+(B’)+(C’)+(D’)



+(E’)

Legal name

[email protected]



subcontracting

To 31/11/2005



Cost model used


Contract n° 505977

TelephoneE-mail

(33) 3 88 65 33 08


Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Direct costs 8853.60


Indirect costs 1770.72Adjustments to previous period(s)

Total costs 10624.32

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Total receipts

Cost model used


Contract n° 505977

TelephoneE-mail

01223 248011


Legal name

[email protected]



subcontracting

To 30/11/05


+(E’)



(E’) (F’) = (A)’+(B’)+(C’)+(D’)




(B) (C) (D) (E)

Total

(A) (F) = (A)+(B)+(C)+(D)+(E)


Innovation



Coordination







Type of Activity

(A’) (B’) (C’) (D’)


Innovation

Demonstration

Period from 1/12/04



Dr Phil Evans

FCCost model used (AC/FC or FCF)


Legal TypeContractors's legal name Medical Research Council

Gov

From -to

NO

YES

Signature

Financial OfficerDr Phil Evans Mr Hugh Dunlop

Date Date

Signature









Third Party 3 (Y3)

Third Party 4 (Y4)


We certify that:





What is the total cost of this(those) audit certificate(s) (in €) per independent auditor(s) ? c€ 800.00









Third Party 2 (Y2)







Please mention the conversion rate used (only one choice is possible) – Please note that the same principle applies for receipts.(0.684300)


7- Conversion rates






30/11/07






From -to

YES

NO



31/11/2007










7- Conversion rates









Third Party 2 (Y2)







What is the total cost of this(those) audit certificate(s) (in €) per independent auditor(s) ? 300 €


Third Party 3 (Y3)

Third Party 4 (Y4)


We certify that:





for the work





Signature




Name of the Person responsible Name of the duly authorised

Signature

Financial OfficerA. Podjarny K. Schaeffer

Date Date21/12/05


Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Direct costs 18,735.99


Indirect costs 3,666.97Adjustments to previous period(s)

Total costs 22,402.96

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Total receipts


+(E’)


Total

(A’) (B’) (C’) (D’) (E’) (F’) = (A)’+(B’)+(C’)+(D’)




Innovation



(F) = (A)+(B)+(C)+(D)+(E)


(B) (C) (D) (E)


Innovation



CoordinationTotal

(A)




Legal name Cost model usedLegal name Cost model usedLegal name Cost model used

If Yes, please provide the following informationLegal name Cost model used

1- Resources (Third party(ies)) Are there any resources made available on the basis of a prior agreement with third parties identified in Annex I of the contract? (Yes / No)

Period from 1/12/04 To 30/11/05

Cost model used (AC/FC or FCF) AC Indirect costs (Real or Flat Rate of 20% of Direct costs, except subcontracting)


subcontracting

Telecopy +351 21 4469314 E-mail [email protected] Person Maria Lurdes Conceicão Telephone +351 21 4469317

Contractors's legal name Instituto de Tecnologia Química e Biológica (ITQB)

Legal Type GOV

Project Title (or Acronym) MAX-INF2 Contract n° 505977


Type of instrument Coordination Action Type of Action (if necessary) Infrastructures

From -to

Signature Signature

Fernando Jorge TavaresDate Date

27/12/05 27/12/05



Name of the Person responsible Name of the duly authorisedfor the work Financial Officer

Profª. Margarida Archer


We certify that:- the costs declared above are directly related to the resources used to reach the objectives of the project ;- the receipts declared above are directly related to the resources used to reach the objectives of the project ;






Third Party 4 (Y4)- Conversion rate of the date of incurred actual costs? (YES / NO)

Third Party 2 (Y2)- Conversion rate of the date of incurred actual costs? (YES / NO) - Conversion rate of the first day of the first month following the period covered by this Financial Statement? (YES/NO)

Third Party 3 (Y3)




Contractor- Conversion rate of the date of incurred actual costs? (YES / NO) - Conversion rate of the first day of the first month following the period covered by this Financial Statement? (YES/NO)

The cost of an audit certificate is included in the costs declared under the activity “Management of the Consortium”.The required audit certificate(s) is (are) attached to this Financial Statement

7- Conversion ratesCosts incurred in currencies other than EURO shall be reported in EURO.

If necessary add another Form C. Total (Z) = (X) + (Ys)Reminders:

Y4 : Legal name of the audit firm Cost of the certificateY3 : Legal name of the audit firm Cost of the certificateY2 : Legal name of the audit firm Cost of the certificate

Audit certificate(s) of the third party(ies) (Ys) (if necessary)Y1 : Legal name of the audit firm Cost of the certificate


Audit certificate of the contractor (X)Legal name of the audit firm Cost of the certificate


If No, what are the periods covered by this(those) audit certificate(s) ? 1/12/04 31/11/2007

6- Audit certificatesAccording to the contract, does this Financial Statement need an audit certificate (or several in case of Third party(ies)) delivered by independent auditor(s)? (Yes / No) No





Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Direct costs


Indirect costs

Adjustments to previous period(s)

Total costs 0 0 0

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Con

trac

tor

Third

Par

ty(ie

s)

Total receipts 0 0

Cost model used


Contract n° 505977

TelephoneE-mail

39-382-985534


Legal name

[email protected]



subcontracting

To 31/11/2005


+(E’)



(E’) (F’) = (A)’+(B’)+(C’)+(D’)




(B) (C) (D) (E)

Total

(A) (F) = (A)+(B)+(C)+(D)+(E)


Innovation



Coordination







Type of Activity

(A’) (B’) (C’) (D’)


Innovation

Demonstration

Period from 1/12/04



Ranzani Guglielmina N


39-382-528496Contact PersonTelecopy

Legal TypeContractors's legal name Dept. Genetics and Microbiology, University of Pavia

Other

From -to

Yes

No

Signature

Financial OfficerAndrea Mattevi Margherita Cremonesi

Date Date2-Jan-06 2-Jan-06

Signature









Third Party 3 (Y3)

Third Party 4 (Y4)


We certify that:














Third Party 2 (Y2)









7- Conversion rates






31/11/2007







FP6 Research Infrastructures 18 Contract [RII3-CT-200X-XXXXXX] Integrated Infrastructure Initiative Annual Report

3. Summary financial report [This section should start on a new page.] [Provide a Summary financial report (Appendix 3) consolidating the costs claimed by each contractor for the reporting period]

1 Page 1/1

Contractor AC Third party(ies)

FC/FCF Third party(ies)













Direct eligible costs 770.08 770.08 0.00 0.00

of which direct eligible costs of subcontracting

0.00 0.00 0.00

Indirect eligible costs 154.02 154.02 0.00 0.00

Adjustment on previous period(s) 0.00 0.00 0.00

Total eligible costs 924.10 0.00 0.00 0.00 0.00 0.00 924.10 0.00 0.00

Direct eligible costs 0.00 0.00 0.00


0.00 0.00 0.00

Indirect eligible costs 0.00 0.00 0.00



Direct eligible costs 13,043.08 13,043.08 0.00 0.00


0.00 0.00 0.00

Indirect eligible costs 2,608.61 2,608.61 0.00 0.00


Total eligible costs 0.00 0.00 15,651.69 0.00 0.00 15,651.69 0.00 0.00



0.00 0.00 0.00



Total eligible costs 0.00 0.00 17,520.00 0.00 0.00 17,520.00 0.00 0.00



0.00 0.00 0.00






0.00 0.00 0.00






0.00 0.00 0.00



Total eligible costs 0.00 0.00 0.00 5,244.61 0.00 0.00 5,244.61 0.00 0.00



0.00 0.00 0.00






0.00 0.00 0.00



2,261.89

9 FUB AC

AC

8 Diamond FC

7 SOLEIL FCF

6 PSI

UNI Vie AC

Other Specific Activities :Coordination

(E)Training

(C)

ESRF

2 CCLRC

3 EMBL

5

Reporting period number

AC1

4

Summary Financial Report

Type of Instrument Contract N° 505977CA infrastructures MAX-INF2Project Title (or Acronym)

Type of activitiesResearch and Technological Development

/ Innovation(A)

From (dd/mm/yyyy)

Management of the consortium(D)Eligible costs

(in €)

December 1, 2004 November 30, 2005To (dd/mm/yyyy)

AC

AC

Contractor n°

Total eligible costs(F)=(A)+(B)+(C)+(D)+(E)Demonstration

(B)Cost model

usedOrganisation

Short Name

FC

U Lund

Receipts




0.00 0.00 0.00






0.00 0.00 0.00






0.00 0.00 0.00






0.00 0.00 0.00






0.00 0.00 0.00






0.00 0.00 0.00






0.00 0.00 0.00




924.10 0.00 0.00 76,299.16 0.00 0.00 77,223.26 0.00 0.00 2,261.89 0.00 0.00

924.10 0.00 0.00 76,299.16 0.00 0.00

14 MRC-LMB

15 ITQB AC

FC

13 CERBM-GIE AC

12 UNIGOE AC

10 York

11 Leiden AC

AC

9 FUB AC

Amount of the financial interests generated by the prefinancing 881.26

74,961.37

77,223.26

76,299.16

924.10

924.10

Requested EC contribution for the reporting period (in €) taking into account receipts [=Periodic Invoice]

76,299.16Requested EC contribution for the reporting period (in €) without

taking into account receipts

Total eligible costs

16 Pavia

77,223.26 2,261.89

AC

C. REPORT ON THE DISTRIBUTION OF THE COMMUNITY FINANCIAL CONTRIBUTION

[Provide the Report on the distribution between contractors made during the reporting period of the Community financial contribution (Appendix 4)]

From To From To From To From To From To From To From To1/12/2004 30/11/2005

Date Amount(A) Date Amount

(B) Date Amount(C) Date Amount

(D) Date Amount(E) Date Amount

(F) Date Amount(G) Date Amount

(H)192,000.00 192,000.00

Contractor n°

Organisation Short Name

Country Code Date(s) (5)

Amount(s)(A') (5)

Date(s) (5)Amount(s)

(B') (5)Date(s) (5)

Amount(s)(C') (5)


(D') (5)Date(s) (5)

Amount(s)(E') (5)


(F') (5)Date(s) (5)

Amount(s)(G') (5)


(H') (5)13/05/2005 46,800.00 46,800.00

0.000.000.00

Total 46,800.00 Total 0.00 Total 0.00 Total 0.00 Total 0.00 Total 0.00 Total 0.00 Total 0.00 46,800.0015/06/2005 1,800.00 1,800.00

0.000.000.00


0.000.000.00


0.000.000.00


0.000.000.00


0.000.000.00


0.000.000.00


0.000.000.00


0.000.000.00


0.000.000.00

Total 1,800.00 Total 0.00 Total 0.00 Total 0.00 Total 0.00 Total 0.00 Total 0.00 Total 0.00 1,800.00

Page n° / 1 2

8 Diamond GB

9 FUB DE

Reporting Period 1 (2)

Reporting Period 4Total Amount

(I') (6)

2 SRS

Reporting Period 5 Final paymentReporting Period 1 Reporting Period 2 Reporting Period 3

Community's prefinancing (or payment) sent to the coordinator (1)

Distribution of the Community's prefinancing (or payment) between contractors according to the consortium decision(s) (4)

Total Amount(I) (3)

Final paymentReporting Period 6 (2) Reporting Period 7 (2)Reporting Period 2 (2) Reporting Period 3 (2) Reporting Period 4 (2) Reporting Period 5 (2)

Reporting Period 6 Reporting Period 7

FR7 Soleil

3 EMBL

4 ESRF

DE

FR

6

Total (X)

SE

GB

PSI CH

5 Vienna A

Part I

Part II

1 MAX-Lab

Report on the Distribution of the Community's contribution

MAX-INF2 505977Contract N°Type of Instrument CA Project Title (or Acronym)

10 York GB

Contractor n°

Organisation Short Name

Country Code Date(s) (5)

Amount(s)(A') (5)


(B') (5)Date(s) (5)

Amount(s)(C') (5)


(D') (5)Date(s) (5)

Amount(s)(E') (5)


(F') (5)Date(s) (5)

Amount(s)(G') (5)


(H') (5)15/06/2005 1,800.00 1,800.00

0.000.000.00


0.000.000.00


0.000.000.00


0.000.000.00


0.000.000.00

Total 23,800.00 Total 0.00 Total 0.00 Total 0.00 Total 0.00 Total 0.00 Total 0.00 Total 0.00 23,800.001,800.00 1,800.00

0.000.000.00



Total Amount

0.00

Explanatory notes Page n° / 2(1): To be filled in only by the Commission services. (2): Established in conformity with articles 4.2 and 6 of the contract.(3): (I) = (A) + (B) + (C) + (D) + (E) + (F) + (G) + (H) (4): To be filled in only by the coordinator. (5): Insert the dates (dd/mm/yyyy) and the amounts (x,xxx.xx €) transferred to a contractor (including the coordinator) for a reporting period. If there are more than one transfer to a contractor during a reporting period, identify each date and each relating transferred amount.(6): (I') = (A') + (B') + (C') + (D') + (E') + (F') + (G') + (H') (7): (Z) = (X) - (Y)(8): One the following persons : authorised contact person or first or second administrative official authorised to sign the contract, as mentioned in your Contract Preparation Form (Form A2b)

14 MRC-LMB GB

Total Amount(I') (6)

11 Leiden NL

Reporting Period 5 Reporting Period 6

15 ITQB PT

12 UNIGOE DE

13 CERBM-GIE FR

Reporting Period 7 Final paymentReporting Period 1 Reporting Period 2 Reporting Period 3 Reporting Period 4

MAX-INF2 Contract N° 505977

Part II Distribution of the Community's prefinancing (or payment) between contractors according to the consortium decision(s) (4)

16 Pavia IT

Report on the Distribution of the Community's contribution

Type of Instrument CA Project Title (or Acronym)

Total (Y)

Part III Difference between Community's prefinancing (or payment) sent to the coordinator and Total Distribution of the Community's prefinancing (or payment) between contractors according to the consortium decision(s) (4)

Reporting Period 1 Reporting Period 2 Reporting Period 3 Reporting Period 4 Reporting Period 5 Reporting Period 6 Reporting Period 7 Final payment

Community's prefinancing (or payment) not yet distributed between contractors (Z) (7)

0.00 0.00 0.00 0.000.00 0.00 0.00 0.00

I certify that the information set out in this(these) form(s) is accurate and correct and agreed by all contractors.

Name (8) Surname (8)Date

(dd/mm/yyyy) Signature of the administrative official authorised to commit the organisation of the coordinator (8)

2

Marjolein Thunnissen 10/1/06

year 1 report - ccp4 · throughput structure determination, ... r. flaig (diamond light source) who...

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