your expertise, our antibodies, accelerated discovery. · 2020-04-15 · ""c dj ,-t,...
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""C DJ ,-t,
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I.O (I) ::J :;:c (I) l"'I 0
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Zymosan BLP I LAM / PGN
Caspase Cascade
IKB Degradation •
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TLR Signaling
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Apoptosis Expression of Pro-inflammatory Cytokines Expression of Type I Interferon
■ Kinase Phosphatase Transcription Factor - - - - - +- Translocation
IKB Degradation
PGN
•.:· '••. +----'>-;-
Apoptosis Expression of Pro-inflammatory Cytokines
NLR Signaling
" MDP / Anthrax toxin
i
Antiviral compounds Danger signals
~~ .. ~ .. Bacterial RNA
i " " Flagellin
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l - - - - - - - - ~ -r----,1_ - - - - - ~..., ;
Autophagy Pro-Inflammatory Cytokine Processing
Caspase Cascade
Apoptosis
Your Expertise, Our Antibodies, Accelerated Discovery.
RLR Signaling dsDNA Sensor Signaling
. ..
Expression of Pro-inflammatory
Cytokines
pppRNA
t +-----------(IR~N~A~ P:::ol~ill!,r----
ER
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Expression of Type I Interferon
------ ----- ------ --- - - - ---------..::. -- -----~
dsDNA
4r 'I'
~ Pro-IL-18
IL-1P
b
Pro-inflammatory Cytokine Processing
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CLR Signaling
l a-Mannose Card factor
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= ~ n ;,
Ca2+ ROS
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Expression of Immune Response Gene
Antigen Presentation TCR Signaling BCR Signaling
Complement System
C3 H20
MASPl MASP2 C3 ~~ ~ y ,;,
Classical pathway Lectln pathway
CS ---C2a
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Lysis of Pathogen
Anaphylatoxin
GeneTex www.genetex.com
Perforin •
• • • . . . . •·· ·. . :-.
Granzym~s
... . ... . . .
Apoptosis
• • - • • • Translocation
International
MHC Class I Pathway
Proteasome
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Cell Destruction
Tel : 886.3.6208988 Fax: 886.3.6208989 Email : [email protected]
. . . . MHC Class II Pathway ·.:.: . . . . . . ..
Induction of Humoral Immunity
Akt Signaling
Cell Survival
• 1·
Actin Reorganization
Cytoskeletal Remodeling
. " . Cyl~
DAG IP3
RasGRPl
IKB NFKB -1:r ~ T ) ..
NFKB - e • ••
Proliferation, Differentiation, Immune Response
■ Kinase ■ Phosphatase ■ Transcription Factor - - - - - • Translocation
USA Tel : 1.949.553.1900 Fax : 1.949.309.2888 Email : [email protected] www.genetex .com
Ca2+
Actin / Reorganization
IP3-----
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Ca2+
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Cell Survival Cytoskeletal Remodeling Immune Response
■ Kinase ■ Phosphatase ■ Transcription Factor • - • • - • Translocation
PP-1001-200327