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Your Global Partner for Manufacturing, Packaging and R&D Solutions
Emerging Trends of HPMC Capsules in
Prescription Pharmaceuticals.
CPHI - Frankfurt
ACG Capsules : Global Footprint
Subsidiaries: Argentina, Bangladesh, Brazil, Canada, China, Croatia, Indonesia, Thailand, UAE, UK,
USA
Manufacturing: Brazil*, Europe, India
Global Head Office: India
Warehouses: Argentina, Brazil, Europe, Indonesia, Thailand, USA
*Manufacturing plant under construction
Co. Sales Manager: Colombia, Germany, France, Spain
Content
• Introduction: Capsules vs tablets
• Capsules types
• HPMC capsules
• Future
4
Capsules vs Tablets
5
New Chemical Entities
Approved by EMEA & FDA
6
0
5
10
15
20
25
30
35
40
45
50
"Tablets "Capsules "Injection "Others
2007
2015
TOP 10 DRUGS LAUNCHES OF 2017NAME COMPANY DISEASE 2022 SALES
ESTIMATE
(billions$)
DOSAGE FORM
Ocrevus Roche Multiple sclerosis 4,1 Injection
Dupixent Sanofi Atopic dermatitis 4,1
Semuglutide Novo Nordisk Diabetes 2,2 Injection
Durvalumab Astra Cancer 1,9 Injection
Niraparib Tesaro Cancer 1,9 Capsules
Baricitinib Lilly Arhtritis 1,8 Capsules
LEE011 Novartis Breast cancer 1,6 Tablets
KTE-C19 Kitepharma Non- Hodkins
Limphoma
1,4 Injection
Ingrezza Neurocrine Dyskinesia 1,3 Capsules
Spinraza Biogen Muscular atrophy 1,3 Injection
Capsule Types
8
TYPES
Gelatin
GelatinPEG
HPMC
9
PROPERTIES
10
GELATIN
Ezeefit
GELATIN-PEG
Ezeefit
HPMC
Naturecaps
ORIGIN ANIMAL ANIMAL VEGETABLE
STRUCTURE PROTEIN PROTEIN CELLULOSE
MOISTURE
CONTENT (%)
13-16 10-12 3-8
BRITTLENESS AT
LOW RH
Yes Medium Very low
CROSSLINKING Yes Yes No
HPMC Capsules
11
HPMC Capsule Types
• With gelling agent (Naturecaps)
• Without gelling agent (Naturecaps Plus)
12
NATURECAPS
• HPMC POLYMER
• GELLING AGENT
• GELLING PROMOTER
13
50-55ºC 50-55ºC
20-25ºC 20-25ºC
NATURECAPS PLUS
14
0
10
20
30
40
50
60
15 20 25 30 35 40 45 50 55 60 65 70 75 80
Viscosity
T(ºC)
HPMC capsules cold vs hot
Cold
Hot
70-80ºC
In vitro test: Naturecaps
15
-20
0
20
40
60
80
100
120
0 5 10 15 20 25 30 35 40 45 50
%
Time (m)
Naturecaps. ph 1,2. Paddle. Paracetamol
HPMC Capsules Dissolution
16
0
20
40
60
80
100
120
0 5 10 15 20 25 30 35 40 45 50
Nature Caps Supplier A
Advantages
• Low moisture content.
• Better mechanical properties. No brittleness at low RH.
• Lack of crosslinking.
• No chemical interaction with APIs.
Correlation RH / HPMC Capsule Moisture Content
18
y = 0.7832e0.0367x
R² = 0.974
0
2
4
6
8
10
12
14
16
0 10 20 30 40 50 60 70 80 90
Capsule
mois
ture
conte
nt(
%)
RH(%)
HPMC capsule moisture content vs Relative humidity
HPMC Capsules for Inhalation (Ezeeflo)
19
From Seebri Neohaler guide
Source “Powder Capsule and Device”. Aurelie Schouben et al. IJP 2015
Capsule puncturing (1/2)
Capsule puncturing (2/2)
Source “Pierce and Inhale”. F. Martinelli et
Capsule spinning
• At 60 l/m the capsule’s
angular velocity can reach
2800 rpm
• The low moment of inertia
of the capsule makes
possible such high values
• The forces generated at
this rotation deagglomerate
the mixture
Computational Fluid Dynamic
23
From “Use of computational modelling” Zhou et al University of
Sidney
Liquid Filling
24
PAST PRESENT
THE PROBLEM
25
Capsule for
liquid filling
26
COMPATIBILITY
27
28
Future
29
Global HPMC Capsule Sales
(by volume in billions)
30
0
10
20
30
40
50
60
70
80
2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022
Wide Range of Capsules
EZEEFITTM
Empty hard gelatin
capsule
NATURECAP
STM Empty hard
Cellulose (HPMC)
capsule
FLOFITTM
Empty hard capsule
for filling liquids
EZEEFLOTM
Empty hard capsule
for Dry Powder
Inhalation
MARINECAPS®
Empty hard fish gelatin
capsule
CLINICAPS®Capsule for double
blind clinical trial
PEARLZTM
Capsule with shiny
pearl-like finish
BRANDSHIELDTM
Pre-printed empty
hard capsule
Explore What Can We Achieve
Together
We believe that our responsibility does not end by supplying the capsules as per
specifications, it begins there. With strive to add tangible value to our
strategic key customers and create a win-win partnership with them
ACG - Values
VALUES WE LIVE.. VALUES THAT MAKES US ACG..
Transparent Aesthetics Nurturing Safety
Synergy Customer Centric Empowerment Dignity