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alterscardiacadaptationtochronichypoxia .RespirPhysiolNeuro biol 2013 186 ): 146-154. SasakiR MasudaS NagaoM.Erythropoietin multiplephysiological functionsandregulationofbiosynthesis .BiosciBiotechnolBio chem 2000 64 ): 1775-1793. MaieseK LiF ChongZZ.Newavenuesofexplorationforerythropoi etin .JAMA 2005 293 ): 90-95. HewitsonKS McNeillLA SchofieldCJ.Modulatingthehypoxiain duciblefactorsignalingpathway applicationsfromcardiovasculardis easetocancer .CurrPharmDes 2004 10 ): 821-833. 10 AnagnostouA LeeES KessimianN etal .Erythropoietinhasami togenicandpositivechemotacticeffectonendothelialcells .Proc NatlAcadSciUSA 1990 87 15 ): 5978-5982. 11 StockmannC FandreyJ.Hypoxiainducederythropoietinproduction aparadigmforoxygenregulatedgeneexpression .ClinExpPhar macolPhysiol 2006 33 10 ): 968-979. 12 EssopMF.Cardiacmetabolicadaptationsinresponsetochronichy poxia .JPhysiol 2007 584 Pt3 ): 715-726. 13 XiaoJ ChenL WangX etal .eNOScorrelateswithmitochondrial biogenesisinheartsofcongenitalheartdiseasewithcyanosis .Arq BrasCardiol 2012 99 ): 780-788. 14 HomJ SheuSS.Morphologicaldynamicsofmitochondriaaspecial emphasisoncardiacmusclecells .JMolCellCardiol 2009 46 ): 811-820. 15 FunkJA OdejinmiS SchnellmannR G.SRT1720inducesmito chondrialbiogenesisandrescuesmitochondrialfunctionafteroxidant injuryinrenalproximaltubulecells.JPharmacolExpTher 2010 333 ): 593-601. 16 EellsJT HenryMM GrossGJ etal .IncreasedmitochondrialK ATP channelactivityduringchronicmyocardialhypoxia iscardio protectionmediatedbyimprovedbioenergetics .CircRes 2000 87 10 ): 915-921. 20130113 20130313 TU V W T 10005404 2013 12119601 %()^;(<3L XYZX[\]^_ 201103UGHUIJ&+ z189:K@-GLMNgô ;<=>?@R540.41   ABCDEJKLMOPQEmail hifen2006go@hotmail.com NOPQhttp //www.cnki.net/kcms/detail/51.1095.R.20130618.0924.001. html 20130618 K@-GLMacutemyocardialinfarction AMI ¥ìKR SMÅTUF¥V®ìM3'u&WÐXYNZ[Îú «íî\ÅKMNZ[m]^ËÆMíîÐÿ1'; ËÒq<ÔÎk$%AMI íî>WÐÊãô_¿Z[ S¨äB-CS-GAB`§@-GM.óabÊØc-GA.M¥;á23Õ-ôgvwÔ´dÔK @-GLMNmíîUeô¤fBQ;ËÒq6- ÃgMºb¦ÓhÐE1 STU= 1.1 `aCb ij 2010  Ñ@ 2012  12 ÑÜ+-./1ÚK@ -GLMãXYNZ[F]^ËÆMíî 96 kß á23FledÌ}YgrmÌn,)opqràâsCSMtuFvw<xyõìKíîY CCUì z{|¹.B}X^e~ 300mg 4XYIbqÔ100~150 ×10 b 100mL ;l Z[m 30min !m{ÂÃà= 5000U : 12 <Eb[ö >d{-GLMMrZ[íîdTÂÔ gFNg 48 abrMZ[²d è8g 48 wrZ[²d0{Nù-ôg¿çg²_¿Bgz¢£{kJwô_ ¿-lÞ²äÂgíîPæ¿ Yìvöf¾¡1.2 -. FNg>c+{rc+иbW ÞÆ¿Pdè8g>FNgMU>-GLM Nm kÑkÑ g¿çg_¿B g#dz¢£UYkJwô_¿-lÞWÞí îbFÖ-çíîÐæ¿Y<K@./ò - rK@-p¡¢²c£Y-¤¥äF¥V#dì ¦ §_¿¨©-CSæç䦪ÎqF@«U_¿½¬_¿a2-ÊM½Õqc®5f- .¯°ÿ-Ùc"VæÔ±>²Y_¿fR ÕÉb_¿Bg|{-ôgΡrävF#d_¿ M³§SpWÞíîMUY"L´M]ºf²Ë1.3 cdef ŵ¶g-¤¥Ö·Ï SAQ PóôÖ¸© 36 SF36 Âkq©Êã;ÆÒq ¹ºSAQ¬- k » u19 kCu¼<k»½¾öf-¤¥£Yæç- ¤¥¥º¦ªZ[¿ÌfõìÚnöfSF36 k»u36 kCu¼<k»½JCS;l@¿0C¾þ JÀ¥JóôÆpÁÂCS¦Ã@¿0§¾<xó ôÂgíî>ym kÑkÑ d!< SF36 P SAQq©¹ÂFÊãÃ1.4 /01gh ab SPSS19 ¤iDÊ㺤qÕ ± ©rg ËÃab z8¤tÕ3©rgËÃab χ z8ij 1209 k# 35 Ï# 12 Ð 2013  Ñ 30 Ò # $ % & ' ( ( Ó J Third Mil Med Univ Vol.35 No.12 Jun.30 2013

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Page 1: ŸSTU= - tmmu.edu.cnaammt.tmmu.edu.cn/Upload/PaperUpLoad/52d2b96a-e165-4eaa...alterscardiacadaptationtochronichypoxia[J].RespirPhysiolNeuro biol,2013,186(2):146-154.

alterscardiacadaptationtochronichypoxia[J].RespirPhysiolNeurobiol,2013,186(2):146-154.

[7]SasakiR,MasudaS,NagaoM.Erythropoietin:multiplephysiologicalfunctionsandregulationofbiosynthesis[J].BiosciBiotechnolBiochem,2000,64(9):1775-1793.

[8]MaieseK,LiF,ChongZZ.Newavenuesofexplorationforerythropoietin[J].JAMA,2005,293(1):90-95.

[9]HewitsonKS,McNeillLA,SchofieldCJ.Modulatingthehypoxiainduciblefactorsignalingpathway:applicationsfromcardiovasculardiseasetocancer[J].CurrPharmDes,2004,10(8):821-833.

[10]AnagnostouA,LeeES,KessimianN,etal.Erythropoietinhasamitogenicandpositivechemotacticeffectonendothelialcells[J].ProcNatlAcadSciUSA,1990,87(15):5978-5982.

[11]StockmannC,FandreyJ.Hypoxiainducederythropoietinproduction:aparadigmforoxygenregulatedgeneexpression[J].ClinExpPharmacolPhysiol,2006,33(10):968-979.

[12]EssopMF.Cardiacmetabolicadaptationsinresponsetochronichy

poxia[J].JPhysiol,2007,584(Pt3):715-726.[13]XiaoJ,ChenL,WangX,etal.eNOScorrelateswithmitochondrial

biogenesisinheartsofcongenitalheartdiseasewithcyanosis[J].ArqBrasCardiol,2012,99(3):780-788.

[14]HomJ,SheuSS.Morphologicaldynamicsofmitochondriaaspecialemphasisoncardiacmusclecells[J].JMolCellCardiol,2009,46(6):811-820.

[15]FunkJA,OdejinmiS,SchnellmannRG.SRT1720inducesmitochondrialbiogenesisandrescuesmitochondrialfunctionafteroxidantinjuryinrenalproximaltubulecells[J].JPharmacolExpTher,2010,333(2):593-601.

[16]EellsJT,HenryMM,GrossGJ,etal.IncreasedmitochondrialK(ATP)channelactivityduringchronicmyocardialhypoxia:iscardioprotectionmediatedbyimprovedbioenergetics[J].CircRes,2000,87(10):915-921.

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Page 2: ŸSTU= - tmmu.edu.cnaammt.tmmu.edu.cn/Upload/PaperUpLoad/52d2b96a-e165-4eaa...alterscardiacadaptationtochronichypoxia[J].RespirPhysiolNeuro biol,2013,186(2):146-154.

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