zebrafish in studies of human health and disease (monte westerfield)
TRANSCRIPT
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Glktc Rcstcrefcio, Skfvcrsfty le Lrcblk, Cubckc, SQ@
Qplkslrco dy thc Leefac le thc Ofrcatlr K`tflk`i Fkstftutcs le Hc`ith,thc K`tflk`i Hug`k Bcklgc Tcsc`rah Fkstftutc,
thc K`tflk`i Fkstftutc le Ahfio Hc`ith & Ocvcilpgckt,
thc K`tflk`i Fkstftutc lk Oc`ekcss & Lthcr Alggukfa`tflk Ofslrocrs,thc K`tflk`i Cyc Fkstftutc,thc Sshcr 0E Alii`dlr`tfvc, ̀ ko thc Gcb`k ̀ ko Ufsflk elr ̀ Aurc Eluko`tflks
]cdr`efsh fk stuofcs le
hug`k hc`ith `ko ofsc`sc
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• Cxpcrfgckt`i `ov`kt`bcs le zcdr`efsh
• ]cdr`efsh `s glocis le hug`k ofsc`sc
• Bckc coftfkb tl bckcr`tc prcafsc glocis le
hug`k bckltypcs
]cdr`efsh fk stuofcs le hug`k hc`ith `ko ofsc`sc
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08 hlur zcdr`ffsh
48 o`y hug`k
Ucrtcdr`tc cgdryls
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Qtuoy ocvcilpgckt ofrcatiy fktr`ksp`rckt cgdryls
(J`ristrlg & J`kc)
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acii-spcafefa prlgltcr BE^_li4 _li4_li4jft
Fkmcat fktl zcdr`efsh
Tcplrtcr alkstruats & hfbhiyceefafckt tr`ksbckcsfs
Qarcck elr rcsauc @ss`ys= LJT, CTB, t`p tcst, ̀ plptlsfs,cta.
Glocis elr tr`ksi`tflk`i stuofcs
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Qtuoy physflilby ofrcatiy
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(Rfijfkslk i`dlr`tlry)
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Qtuoy dillo eilw ofrcatiy fk ifvc `kfg`is
(Q`ktlrl i`dlr`tlry)
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R`tah ocvcilpgckt ofrcatiy fk ifvc `kfg`i
(Ifkj i`dlr`tlry)
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Algpicx dch`vflrs - prcy a`pturc
(Ckbcrt i`dlr`tlry)
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(Jciicr & @hrcks, 4>01)
Qtuoy `atfvfty le cvcry kcurlk fk thcdr`fk sfguit`kclusiy
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Hfbh-thrlubhput lptfa`i sarcckfkb
(^`rol-G`rtfk ct `i., 4>0>)
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Rfio-typc
Gut`kt
kl t`fi (kti )
(Jfggci i`dlr`tlry)
Dloy `xfs ocvcilpgckt
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Rfio-typc
Gut`kt
.
Acrcdciiug
`acrcdcii`r (`ac )
Dr`fk ocvcilpgckt
(Kùssicfk-Ulih`ro i`dlr`tlry)
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Klrg`i Ayailps gut`kt
Cyc ocvcilpgckt
(Jfggci i`dlr`tlry)
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_hlus`kos le gut`kts- ` - f =
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ruru`:#
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Jklaj lut le `ii prltcfk alofkb bckcs
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Tcvcrsc bckctfa tcahklilby
ATFQ^Ts - Aiustcrco Tcbui`riyFktcrsp`aco Qhlrt ^`ifkorlgfa Tcpc`ts
GLT^HLIFKLQ- `ktfscksc lifblkuaicltfocs
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Glrphlifkls vs bckc coftfkb
(Jlj ct `i., 4>03)
Elr 8>% le bckcs, glrphlifkl phckltypcs
`rc klt ldscrvco fk gut`kts
Glrphlifkl ATFQ^T/_@ICK@ov`kt`bcs Ofs`ov`kt`bcs
Qtuoy ofrcatiy fkfkmcatco `kfg`is
Qtuoy fk st`dic ifkcs
C`sy tl usc Tcqufrcs drccofkb &
bckltypfkbDilajs g`tcrk`igcss`bc
Tcqufrcs g`tcrk`i zybltfagut`kts tl dilaj g`tcrk`iprlouats
Ofs`ov`kt`bcs @ov`kt`bcs
Ofiutco lvcr tfgc ‑ifgftco tl c`riy
ocvcilpgckt`i st`bcs
Bckctfa`iiy st`dic ‑ a`kstuoy `t `ii ocvcilpgckt`i
st`bcs fkaiuofkb `ouits
Fkouacs p31ocpckockt `plptlsfs
Ilw tlxfafty
Lee t`rbct ceecats Hfbhiy spcafefa
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Glrphlifkls vs bckc coftfkb
(Jlj ct `i., 4>03)
Elr 8>% le bckcs, glrphlifkl phckltypcs
`rc klt ldscrvco fk gut`kts
Glrphlifkl ATFQ^T/_@ICK@ov`kt`bcs Ofs`ov`kt`bcs
Qtuoy ofrcatiy fkfkmcatco `kfg`is
Qtuoy fk st`dic ifkcs
C`sy tl usc Tcqufrcs drccofkb &
bckltypfkbDilajs g`tcrk`igcss`bc
Tcqufrcs g`tcrk`i zybltfagut`kts tl dilaj g`tcrk`iprlouats
Ofs`ov`kt`bcs @ov`kt`bcs
Ofiutco lvcr tfgc ‑ifgftco tl c`riy
ocvcilpgckt`i st`bcs
Bckctfa`iiy st`dic ‑ a`kstuoy `t `ii ocvcilpgckt`i
st`bcs fkaiuofkb `ouits
Fkouacs p31ocpckockt `plptlsfs
Ilw tlxfafty
Lee t`rbct ceecats Hfbhiy spcafefa
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Bckc coftfkb fs dcalgfkb ` prfg`rybckctfa tcahklilby fk zcdr`efsh rcsc`rah
_@ICKs
ATFQ^Ts
Glrphlifkls (x >.4)
^ u d i f a ` t f l k s
>
0>
4>
1>
?>
3>
Vc`r
4>0> 4>00 4>04 4>01 4>0? 4>03
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• Cxpcrfgckt`i `ov`kt`bcs le zcdr`efsh
• ]cdr`efsh `s glocis le hug`k ofsc`sc
• Bckc coftfkb tl bckcr`tc prcafsc glocis le
hug`k bckltypcs
]cdr`efsh fk stuofcs le hug`k hc`ith `ko ofsc`sc
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zcdr`efsh eiy
hug`k
zcdr`efsh
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@autc r`of`tflk sykorlgc
@bc-rci`tco g`aui`r ocbckcr`tflk
@ialhlifsg
@ialhlifa ifvcr ofsc`sc @izhcfgcrs ofsc`sc @klphth`igf`
@kxfcty ofslrocrs
@thcrlsaicrlsfs @utfsg
@utlslg`i olgfk`kt hc`rfkb ofsc`sc @xckecio-Tfcbcr sykorlgc
D`roct-Dfcoi sykorlgc
D`rth sykorlgcDfauspfo `lrtfa v`ivc ofsc`sc
Dfif`ry ̀ trcsf`
A`kacrAlilrcat`i a`kacr
Hc`o `ko kcaj squ`glus acii a`rafklg`Biflg`
Fkv`sfvc a`rafklg`ICL^@TO sykorlgc
Icujcgf`
Ifvcr a`kacrIygphldi`stfa icujcgf`
Gci`klg`Gylilbcklus icucjgf`
Kcurldi`stlg`
^`karc`tfa a`kacrTh`dolgyls`ralg`
Acktrlkuaic`r gylp`thfcsAcrcdr`i a`vcrklus g`ielrg`tflks
Ahlicr`
Ahrlkfa br`kuilg`tlus ofsc`scAhrlkfa jfokcy ofsc`sc
Afraui`tlry ofsc`scsAliftfs
Alkbckft`i a`t`r`at
Alkbckft`i biyalsiy`tflk ofsc`scsAlrc dfkofkb e`atlr icujcgf`
Alrkc`i oystrlphfcs
Ar`kf`i e`af`i ofsc`scs
Arlhks ofsc`sc
Autfs i`x`Aystfa efdrlsfsOci`yco pudcrty
Of`dctcs
Of`glko Di`aje`k `kcgf`Ouahckkc gusaui`r oystrlphy
Cko st`bc rck`i ofsc`scCgphyscg`
Cpficpsy
Cxtrfksfa ̀ sthg`Cyc ofsc`scs
E`aflsa`puilhugcr`i gusaui`r oystrlphy
E`kalkf `kcgf`E`tty ifvcr ofsc`scEct`i `ialhli sykorlgc
Ela`i scbgckt`i bilgcruilsaicrlsfs
Er`scr sykorlgcB`kbiflsfoc sf`ifo`sc ocefafckay ofsc`sc
B@^L prlbcrlfo sykorlgcBi`ualg`
Bifldi`stlg`
Hc`rt ofsc`sc @trf`i efdrfii`tflk
A`rof`a ̀ rrhythgf`
A`rof`a alkouatflk ofsc`scsA`roflgcb`iy
Alkbcstfvc hc`rt e`fiurcHypcrtrlphfa a`roflgylp`thy
Quoock a`rof`a `rrcstHcp`tfa stc`tlsfs
Hcrcoft`ry rctfk`i ocbckcr`tflks
Hfrsahsprukb ofsc`scHFU@FOQ
Hlit Lr`g sykorlgcHypcr`gglkcgf`
Hypcrtcksflk
Fkei`gg`tlry dlwci ofsc`sc
Fktr`ar`kf`i ̀ kcurysg
Mludcrt sykorlgc
Muvckfic hyorlacph`iusJfokcy ofsc`scsIlkb P_ sykorlgc
Iyslslg`i ofsc`sc gualifpfolsfs FF
Gfarlphth`gf`Gfoe`af`i aicet ofsc`sc
Guitfpic saicrlsfsGualifpfolsfs typc FU
Gusaui`r oystrlphy
Gyltlkfa oystrlphyKcphrlklphthfsfs
Klksykorlgfa aicet ifp `ko p`i`tc
Kllk`k sykorlgcLdcsfty
Lr`i aicet ofsc`scsLstclplrlsfs
^`rjfkslk ofsc`sc^liyaystfa jfokcy ofsc`sc
^scuolx`kthlg` ci`stfaug
Tcer`atlry ̀ kcgf`Qahfzlphrckf`
QaliflsfsQjcict`i ofsc`scs
Qiccp ofslrocrs
Qpfk`i alro rcbckcr`tflkQpfk`i gusaui`r `trlphy
Qtrljc_rc`ahcr Aliifks sykorlgc
_udcrauilsfs
Sshcr sykorlgcSvc`i alildlg`
U`saui r̀ thrlgdlsfsvlk Rfiicdr`ko ofsc`sc
Hug`k ofsc`scs stuofco wfth zcdr`efsh glocis
(KFH eukoco br`kts, 4>01)
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@autc r`of`tflk sykorlgc
@bc-rci`tco g`aui`r ocbckcr`tflk
@ialhlifsg
@ialhlifa ifvcr ofsc`sc @izhcfgcrs ofsc`sc @klphth`igf`
@kxfcty ofslrocrs
@thcrlsaicrlsfs @utfsg
@utlslg`i olgfk`kt hc`rfkb ofsc`sc @xckecio-Tfcbcr sykorlgc
D`roct-Dfcoi sykorlgc
D`rth sykorlgcDfauspfo `lrtfa v`ivc ofsc`sc
Dfif`ry ̀ trcsf`
A`kacrAlilrcat`i a`kacr
Hc`o `ko kcaj squ`glus acii a`rafklg`Biflg`
Fkv`sfvc a`rafklg`ICL^@TO sykorlgc
Icujcgf`
Ifvcr a`kacrIygphldi`stfa icujcgf`
Gci`klg`Gylilbcklus icucjgf`
Kcurldi`stlg`
^`karc`tfa a`kacrTh`dolgyls`ralg`
Acktrlkuaic`r gylp`thfcsAcrcdr`i a`vcrklus g`ielrg`tflks
Ahlicr`
Ahrlkfa br`kuilg`tlus ofsc`scAhrlkfa jfokcy ofsc`sc
Afraui`tlry ofsc`scsAliftfs
Alkbckft`i a`t`r`at
Alkbckft`i biyalsiy`tflk ofsc`scsAlrc dfkofkb e`atlr icujcgf`
Alrkc`i oystrlphfcs
Ar`kf`i e`af`i ofsc`scs
Arlhks ofsc`sc
Autfs i`x`Aystfa efdrlsfsOci`yco pudcrty
Of`dctcs
Of`glko Di`aje`k `kcgf`Ouahckkc gusaui`r oystrlphy
Cko st`bc rck`i ofsc`scCgphyscg`
Cpficpsy
Cxtrfksfa ̀ sthg`Cyc ofsc`scs
E`aflsa`puilhugcr`i gusaui`r oystrlphy
E`kalkf `kcgf`E`tty ifvcr ofsc`scEct`i `ialhli sykorlgc
Ela`i scbgckt`i bilgcruilsaicrlsfs
Er`scr sykorlgcB`kbiflsfoc sf`ifo`sc ocefafckay ofsc`sc
B@^L prlbcrlfo sykorlgcBi`ualg`
Bifldi`stlg`
Hc`rt ofsc`sc @trf`i efdrfii`tflk
A`rof`a ̀ rrhythgf`
A`rof`a alkouatflk ofsc`scsA`roflgcb`iy
Alkbcstfvc hc`rt e`fiurcHypcrtrlphfa a`roflgylp`thy
Quoock a`rof`a `rrcstHcp`tfa stc`tlsfs
Hcrcoft`ry rctfk`i ocbckcr`tflks
Hfrsahsprukb ofsc`scHFU@FOQ
Hlit Lr`g sykorlgcHypcr`gglkcgf`
Hypcrtcksflk
Fkei`gg`tlry dlwci ofsc`sc
Fktr`ar`kf`i ̀ kcurysg
Mludcrt sykorlgc
Muvckfic hyorlacph`iusJfokcy ofsc`scsIlkb P_ sykorlgc
Iyslslg`i ofsc`sc gualifpfolsfs FF
Gfarlphth`gf`Gfoe`af`i aicet ofsc`sc
Guitfpic saicrlsfsGualifpfolsfs typc FU
Gusaui`r oystrlphy
Gyltlkfa oystrlphyKcphrlklphthfsfs
Klksykorlgfa aicet ifp `ko p`i`tc
Kllk`k sykorlgcLdcsfty
Lr`i aicet ofsc`scsLstclplrlsfs
^`rjfkslk ofsc`sc^liyaystfa jfokcy ofsc`sc
^scuolx`kthlg` ci`stfaug
Tcer`atlry ̀ kcgf`Qahfzlphrckf`
QaliflsfsQjcict`i ofsc`scs
Qiccp ofslrocrs
Qpfk`i alro rcbckcr`tflkQpfk`i gusaui`r `trlphy
Qtrljc_rc`ahcr Aliifks sykorlgc
_udcrauilsfs
Sshcr sykorlgcSvc`i alildlg`
U`saui r̀ thrlgdlsfsvlk Rfiicdr`ko ofsc`sc
Hug`k ofsc`scs stuofco wfth zcdr`efsh glocis
(KFH eukoco br`kts, 4>01)
@izhcfgcrs Ofsc`sc
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@autc r`of`tflk sykorlgc
@bc-rci`tco g`aui`r ocbckcr`tflk
@ialhlifsg
@ialhlifa ifvcr ofsc`sc @izhcfgcrs ofsc`sc @klphth`igf`
@kxfcty ofslrocrs
@thcrlsaicrlsfs @utfsg
@utlslg`i olgfk`kt hc`rfkb ofsc`sc @xckecio-Tfcbcr sykorlgc
D`roct-Dfcoi sykorlgc
D`rth sykorlgcDfauspfo `lrtfa v`ivc ofsc`sc
Dfif`ry ̀ trcsf`
A`kacrAlilrcat`i a`kacr
Hc`o `ko kcaj squ`glus acii a`rafklg`Biflg`
Fkv`sfvc a`rafklg`ICL^@TO sykorlgc
Icujcgf`
Ifvcr a`kacrIygphldi`stfa icujcgf`
Gci`klg`Gylilbcklus icucjgf`
Kcurldi`stlg`
^`karc`tfa a`kacrTh`dolgyls`ralg`
Acktrlkuaic`r gylp`thfcsAcrcdr`i a`vcrklus g`ielrg`tflks
Ahlicr`
Ahrlkfa br`kuilg`tlus ofsc`scAhrlkfa jfokcy ofsc`sc
Afraui`tlry ofsc`scsAliftfs
Alkbckft`i a`t`r`at
Alkbckft`i biyalsiy`tflk ofsc`scsAlrc dfkofkb e`atlr icujcgf`
Alrkc`i oystrlphfcs
Ar`kf`i e`af`i ofsc`scs
Arlhks ofsc`sc
Autfs i`x`Aystfa efdrlsfsOci`yco pudcrty
Of`dctcs
Of`glko Di`aje`k `kcgf`Ouahckkc gusaui`r oystrlphy
Cko st`bc rck`i ofsc`scCgphyscg`
Cpficpsy
Cxtrfksfa ̀ sthg`Cyc ofsc`scs
E`aflsa`puilhugcr`i gusaui`r oystrlphy
E`kalkf `kcgf`E`tty ifvcr ofsc`scEct`i `ialhli sykorlgc
Ela`i scbgckt`i bilgcruilsaicrlsfs
Er`scr sykorlgcB`kbiflsfoc sf`ifo`sc ocefafckay ofsc`sc
B@^L prlbcrlfo sykorlgcBi`ualg`
Bifldi`stlg`
Hc`rt ofsc`sc @trf`i efdrfii`tflk
A`rof`a ̀ rrhythgf`
A`rof`a alkouatflk ofsc`scsA`roflgcb`iy
Alkbcstfvc hc`rt e`fiurcHypcrtrlphfa a`roflgylp`thy
Quoock a`rof`a `rrcstHcp`tfa stc`tlsfs
Hcrcoft`ry rctfk`i ocbckcr`tflks
Hfrsahsprukb ofsc`scHFU@FOQ
Hlit Lr`g sykorlgcHypcr`gglkcgf`
Hypcrtcksflk
Fkei`gg`tlry dlwci ofsc`sc
Fktr`ar`kf`i ̀ kcurysg
Mludcrt sykorlgc
Muvckfic hyorlacph`iusJfokcy ofsc`scsIlkb P_ sykorlgc
Iyslslg`i ofsc`sc gualifpfolsfs FF
Gfarlphth`gf`Gfoe`af`i aicet ofsc`sc
Guitfpic saicrlsfsGualifpfolsfs typc FU
Gusaui`r oystrlphy
Gyltlkfa oystrlphyKcphrlklphthfsfs
Klksykorlgfa aicet ifp `ko p`i`tc
Kllk`k sykorlgcLdcsfty
Lr`i aicet ofsc`scsLstclplrlsfs
^`rjfkslk ofsc`sc^liyaystfa jfokcy ofsc`sc
^scuolx`kthlg` ci`stfaug
Tcer`atlry ̀ kcgf`Qahfzlphrckf`
QaliflsfsQjcict`i ofsc`scs
Qiccp ofslrocrs
Qpfk`i alro rcbckcr`tflkQpfk`i gusaui`r `trlphy
Qtrljc_rc`ahcr Aliifks sykorlgc
_udcrauilsfs
Sshcr sykorlgcSvc`i alildlg`
U`saui r̀ thrlgdlsfsvlk Rfiicdr`ko ofsc`sc
Hug`k ofsc`scs stuofco wfth zcdr`efsh glocis
(KFH eukoco br`kts, 4>01)
A`kacrs
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@autc r`of`tflk sykorlgc
@bc-rci`tco g`aui`r ocbckcr`tflk
@ialhlifsg
@ialhlifa ifvcr ofsc`sc @izhcfgcrs ofsc`sc @klphth`igf`
@kxfcty ofslrocrs
@thcrlsaicrlsfs @utfsg
@utlslg`i olgfk`kt hc`rfkb ofsc`sc @xckecio-Tfcbcr sykorlgc
D`roct-Dfcoi sykorlgc
D`rth sykorlgcDfauspfo `lrtfa v`ivc ofsc`sc
Dfif`ry ̀ trcsf`
A`kacrAlilrcat`i a`kacr
Hc`o `ko kcaj squ`glus acii a`rafklg`Biflg`
Fkv`sfvc a`rafklg`ICL^@TO sykorlgc
Icujcgf`
Ifvcr a`kacrIygphldi`stfa icujcgf`
Gci`klg`Gylilbcklus icucjgf`
Kcurldi`stlg`
^`karc`tfa a`kacrTh`dolgyls`ralg`
Acktrlkuaic`r gylp`thfcsAcrcdr`i a`vcrklus g`ielrg`tflks
Ahlicr`
Ahrlkfa br`kuilg`tlus ofsc`scAhrlkfa jfokcy ofsc`sc
Afraui`tlry ofsc`scsAliftfs
Alkbckft`i a`t`r`at
Alkbckft`i biyalsiy`tflk ofsc`scsAlrc dfkofkb e`atlr icujcgf`
Alrkc`i oystrlphfcs
Ar`kf`i e`af`i ofsc`scs
Arlhks ofsc`sc
Autfs i`x`Aystfa efdrlsfsOci`yco pudcrty
Of`dctcs
Of`glko Di`aje`k `kcgf`Ouahckkc gusaui`r oystrlphy
Cko st`bc rck`i ofsc`scCgphyscg`
Cpficpsy
Cxtrfksfa ̀ sthg`Cyc ofsc`scs
E`aflsa`puilhugcr`i gusaui`r oystrlphy
E`kalkf `kcgf`E`tty ifvcr ofsc`scEct`i `ialhli sykorlgc
Ela`i scbgckt`i bilgcruilsaicrlsfs
Er`scr sykorlgcB`kbiflsfoc sf`ifo`sc ocefafckay ofsc`sc
B@^L prlbcrlfo sykorlgcBi`ualg`
Bifldi`stlg`
Hc`rt ofsc`sc @trf`i efdrfii`tflk
A`rof`a ̀ rrhythgf`
A`rof`a alkouatflk ofsc`scsA`roflgcb`iy
Alkbcstfvc hc`rt e`fiurcHypcrtrlphfa a`roflgylp`thy
Quoock a`rof`a `rrcstHcp`tfa stc`tlsfs
Hcrcoft`ry rctfk`i ocbckcr`tflks
Hfrsahsprukb ofsc`scHFU@FOQ
Hlit Lr`g sykorlgcHypcr`gglkcgf`
Hypcrtcksflk
Fkei`gg`tlry dlwci ofsc`sc
Fktr`ar`kf`i ̀ kcurysg
Mludcrt sykorlgc
Muvckfic hyorlacph`iusJfokcy ofsc`scsIlkb P_ sykorlgc
Iyslslg`i ofsc`sc gualifpfolsfs FF
Gfarlphth`gf`Gfoe`af`i aicet ofsc`sc
Guitfpic saicrlsfsGualifpfolsfs typc FU
Gusaui`r oystrlphy
Gyltlkfa oystrlphyKcphrlklphthfsfs
Klksykorlgfa aicet ifp `ko p`i`tc
Kllk`k sykorlgcLdcsfty
Lr`i aicet ofsc`scsLstclplrlsfs
^`rjfkslk ofsc`sc^liyaystfa jfokcy ofsc`sc
^scuolx`kthlg` ci`stfaug
Tcer`atlry ̀ kcgf`Qahfzlphrckf`
QaliflsfsQjcict`i ofsc`scs
Qiccp ofslrocrs
Qpfk`i alro rcbckcr`tflkQpfk`i gusaui`r `trlphy
Qtrljc_rc`ahcr Aliifks sykorlgc
_udcrauilsfs
Sshcr sykorlgcSvc`i alildlg`
U`saui r̀ thrlgdlsfsvlk Rfiicdr`ko ofsc`sc
Hug`k ofsc`scs stuofco wfth zcdr`efsh glocis
(KFH eukoco br`kts, 4>01)
Ldcsfty
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@autc r`of`tflk sykorlgc
@bc-rci`tco g`aui`r ocbckcr`tflk
@ialhlifsg
@ialhlifa ifvcr ofsc`sc @izhcfgcrs ofsc`sc @klphth`igf`
@kxfcty ofslrocrs
@thcrlsaicrlsfs @utfsg
@utlslg`i olgfk`kt hc`rfkb ofsc`sc @xckecio-Tfcbcr sykorlgc
D`roct-Dfcoi sykorlgc
D`rth sykorlgcDfauspfo `lrtfa v`ivc ofsc`sc
Dfif`ry ̀ trcsf`
A`kacrAlilrcat`i a`kacr
Hc`o `ko kcaj squ`glus acii a`rafklg`Biflg`
Fkv`sfvc a`rafklg`ICL^@TO sykorlgc
Icujcgf`
Ifvcr a`kacrIygphldi`stfa icujcgf`
Gci`klg`Gylilbcklus icucjgf`
Kcurldi`stlg`
^`karc`tfa a`kacrTh`dolgyls`ralg`
Acktrlkuaic`r gylp`thfcsAcrcdr`i a`vcrklus g`ielrg`tflks
Ahlicr`
Ahrlkfa br`kuilg`tlus ofsc`scAhrlkfa jfokcy ofsc`sc
Afraui`tlry ofsc`scsAliftfs
Alkbckft`i a`t`r`at
Alkbckft`i biyalsiy`tflk ofsc`scsAlrc dfkofkb e`atlr icujcgf`
Alrkc`i oystrlphfcs
Ar`kf`i e`af`i ofsc`scs
Arlhks ofsc`sc
Autfs i`x`Aystfa efdrlsfsOci`yco pudcrty
Of`dctcs
Of`glko Di`aje`k `kcgf`Ouahckkc gusaui`r oystrlphy
Cko st`bc rck`i ofsc`scCgphyscg`
Cpficpsy
Cxtrfksfa ̀ sthg`Cyc ofsc`scs
E`aflsa`puilhugcr`i gusaui`r oystrlphy
E`kalkf `kcgf`E`tty ifvcr ofsc`scEct`i `ialhli sykorlgc
Ela`i scbgckt`i bilgcruilsaicrlsfs
Er`scr sykorlgcB`kbiflsfoc sf`ifo`sc ocefafckay ofsc`sc
B@^L prlbcrlfo sykorlgcBi`ualg`
Bifldi`stlg`
Hc`rt ofsc`sc @trf`i efdrfii`tflk
A`rof`a ̀ rrhythgf`
A`rof`a alkouatflk ofsc`scsA`roflgcb`iy
Alkbcstfvc hc`rt e`fiurcHypcrtrlphfa a`roflgylp`thy
Quoock a`rof`a `rrcstHcp`tfa stc`tlsfs
Hcrcoft`ry rctfk`i ocbckcr`tflks
Hfrsahsprukb ofsc`scHFU@FOQ
Hlit Lr`g sykorlgcHypcr`gglkcgf`
Hypcrtcksflk
Fkei`gg`tlry dlwci ofsc`sc
Fktr`ar`kf`i ̀ kcurysg
Mludcrt sykorlgc
Muvckfic hyorlacph`iusJfokcy ofsc`scsIlkb P_ sykorlgc
Iyslslg`i ofsc`sc gualifpfolsfs FF
Gfarlphth`gf`Gfoe`af`i aicet ofsc`sc
Guitfpic saicrlsfsGualifpfolsfs typc FU
Gusaui`r oystrlphy
Gyltlkfa oystrlphyKcphrlklphthfsfs
Klksykorlgfa aicet ifp `ko p`i`tc
Kllk`k sykorlgcLdcsfty
Lr`i aicet ofsc`scsLstclplrlsfs
^`rjfkslk ofsc`sc^liyaystfa jfokcy ofsc`sc
^scuolx`kthlg` ci`stfaug
Tcer`atlry ̀ kcgf`Qahfzlphrckf`
QaliflsfsQjcict`i ofsc`scs
Qiccp ofslrocrs
Qpfk`i alro rcbckcr`tflkQpfk`i gusaui`r `trlphy
Qtrljc_rc`ahcr Aliifks sykorlgc
_udcrauilsfs
Sshcr sykorlgcSvc`i alildlg`
U`saui r̀ thrlgdlsfsvlk Rfiicdr`ko ofsc`sc
Hug`k ofsc`scs stuofco wfth zcdr`efsh glocis
(KFH eukoco br`kts, 4>01)
Qahfzlphrckf`
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@autc r`of`tflk sykorlgc
@bc-rci`tco g`aui`r ocbckcr`tflk
@ialhlifsg
@ialhlifa ifvcr ofsc`sc @izhcfgcrs ofsc`sc @klphth`igf`
@kxfcty ofslrocrs
@thcrlsaicrlsfs @utfsg
@utlslg`i olgfk`kt hc`rfkb ofsc`sc @xckecio-Tfcbcr sykorlgc
D`roct-Dfcoi sykorlgc
D`rth sykorlgcDfauspfo `lrtfa v`ivc ofsc`sc
Dfif`ry ̀ trcsf`
A`kacrAlilrcat`i a`kacr
Hc`o `ko kcaj squ`glus acii a`rafklg`Biflg`
Fkv`sfvc a`rafklg`ICL^@TO sykorlgc
Icujcgf`
Ifvcr a`kacrIygphldi`stfa icujcgf`
Gci`klg`Gylilbcklus icucjgf`
Kcurldi`stlg`
^`karc`tfa a`kacrTh`dolgyls`ralg`
Acktrlkuaic`r gylp`thfcsAcrcdr`i a`vcrklus g`ielrg`tflks
Ahlicr`
Ahrlkfa br`kuilg`tlus ofsc`scAhrlkfa jfokcy ofsc`sc
Afraui`tlry ofsc`scsAliftfs
Alkbckft`i a`t`r`at
Alkbckft`i biyalsiy`tflk ofsc`scsAlrc dfkofkb e`atlr icujcgf`
Alrkc`i oystrlphfcs
Ar`kf`i e`af`i ofsc`scs
Arlhks ofsc`sc
Autfs i`x`Aystfa efdrlsfsOci`yco pudcrty
Of`dctcs
Of`glko Di`aje`k `kcgf`Ouahckkc gusaui`r oystrlphy
Cko st`bc rck`i ofsc`scCgphyscg`
Cpficpsy
Cxtrfksfa ̀ sthg`Cyc ofsc`scs
E`aflsa`puilhugcr`i gusaui`r oystrlphy
E`kalkf `kcgf`E`tty ifvcr ofsc`scEct`i `ialhli sykorlgc
Ela`i scbgckt`i bilgcruilsaicrlsfs
Er`scr sykorlgcB`kbiflsfoc sf`ifo`sc ocefafckay ofsc`sc
B@^L prlbcrlfo sykorlgcBi`ualg`
Bifldi`stlg`
Hc`rt ofsc`sc @trf`i efdrfii`tflk
A`rof`a ̀ rrhythgf`
A`rof`a alkouatflk ofsc`scsA`roflgcb`iy
Alkbcstfvc hc`rt e`fiurcHypcrtrlphfa a`roflgylp`thy
Quoock a`rof`a `rrcstHcp`tfa stc`tlsfs
Hcrcoft`ry rctfk`i ocbckcr`tflks
Hfrsahsprukb ofsc`scHFU@FOQ
Hlit Lr`g sykorlgcHypcr`gglkcgf`
Hypcrtcksflk
Fkei`gg`tlry dlwci ofsc`sc
Fktr`ar`kf`i ̀ kcurysg
Mludcrt sykorlgc
Muvckfic hyorlacph`iusJfokcy ofsc`scsIlkb P_ sykorlgc
Iyslslg`i ofsc`sc gualifpfolsfs FF
Gfarlphth`gf`Gfoe`af`i aicet ofsc`sc
Guitfpic saicrlsfsGualifpfolsfs typc FU
Gusaui`r oystrlphy
Gyltlkfa oystrlphyKcphrlklphthfsfs
Klksykorlgfa aicet ifp `ko p`i`tc
Kllk`k sykorlgcLdcsfty
Lr`i aicet ofsc`scsLstclplrlsfs
^`rjfkslk ofsc`sc^liyaystfa jfokcy ofsc`sc
^scuolx`kthlg` ci`stfaug
Tcer`atlry ̀ kcgf`Qahfzlphrckf`
QaliflsfsQjcict`i ofsc`scs
Qiccp ofslrocrs
Qpfk`i alro rcbckcr`tflkQpfk`i gusaui`r `trlphy
Qtrljc_rc`ahcr Aliifks sykorlgc
_udcrauilsfs
Sshcr sykorlgcSvc`i alildlg`
U`saui r̀ thrlgdlsfsvlk Rfiicdr`ko ofsc`sc
Hug`k ofsc`scs stuofco wfth zcdr`efsh glocis
(KFH eukoco br`kts, 4>01)
Sshcr sykorlgc
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Sshcr sykorlgc - thc ic`ofkb a`usc le oc`edifkokcss
• ^rcv`ickac ! 0 pcr 5,>>> dfrths fk thc SQ
(glrc algglk th`k @IQ lr Huktfkbtlk‖s Ofsc`sc)
• Alkbckft`i oc`ekcss (~?% le oc`e h`vc Sshcr)
Qckslrfkcur`i hc`rfkb ilssUcstfdui`r oyseukatflk
• Tctfkftfs pfbgcktls`Ilss le rlo phltlrcacptlrs
^rlbrcssfvc tukkci vfsflk `s alkcs ofc
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T4?3X gut`tflk truka`tcs thc ^AOH03 prltcfka`usfkb Sshcr sykorlgc typc 0E
T4?3X fs algglk fk thc @shjck`zf Mcwfsh alggukfty- `aalukts elr ~53% le Sshcr 0 p`tfckts
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Cxlk sjfppfkb `s str`tcby elr thcr`py
020 dp(32`` - fk er`gc)
04 Jd 8> Jd
sftc le prcg`turc tcrgfk`tflk
alolk fk T4?3X p`tfckts
`sl0 `sl4
C2 C8 C6
C2 C6
Cxlk 8 ocictco erlg tr`ksarfpt
^AOH03 prc-gTK@
^AOH03 g`turc gTK@
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Cxlk sjfppfkb `s str`tcby elr thcr`py
04 Jd 8> Jd
T4?3X
C2 C6C8
]cdr`efsh bckc
^rcafsc gloci lehug`k gut`tflk
Hug`k cxlk +
Ei`kjfkb fktrlk scquckacs
ATFQ^T
C8
04 Jd 8> Jd
C2 C6C8
T4?3X
`sl0 `sl4
C8
]cdr`efsh hlglilby`rgs
+
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• Cxpcrfgckt`i `ov`kt`bcs le zcdr`efsh
• ]cdr`efsh `s glocis le hug`k ofsc`sc
• Bckc coftfkb tl bckcr`tc prcafsc glocis le
hug`k bckltypcs - 122 bckcs t`rbctco sfkac 4>00
]cdr`efsh fk stuofcs le hug`k hc`ith `ko ofsc`sc
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Glktc Rcstcrefcio, Skfvcrsfty le Lrcblk, Cubckc, SQ@
Qplkslrco dy thc Leefac le thc Ofrcatlr K`tflk`i Fkstftutcs le Hc`ith,thc K`tflk`i Hug`k Bcklgc Tcsc`rah Fkstftutc,
thc K`tflk`i Fkstftutc le Ahfio Hc`ith & Ocvcilpgckt,thc K`tflk`i Fkstftutc lk Oc`ekcss & Lthcr Alggukfa`tflk Ofslrocrs,
thc K`tflk`i Cyc Fkstftutc,thc Sshcr 0E Alii`dlr`tfvc, ̀ ko thc Gcb`k ̀ ko Ufsflk elr ̀ Aurc Eluko`tflks
]cdr`efsh fk stuofcs le
hug`k hc`ith `ko ofsc`sc