zenivex is a trademark of wellmark international dba central life sciences. ©2008 wellmark...

Zenivex is a trademark of Wellmark International dba Central Life Sciences. ©2008 Wellmark International.Always read and follow label directions.

Mel WhitsonEntomologist/Region Manager

Florida and Caribbean

A new, highly effective, reduced riskmosquito adulticide is coming.


Introducing a New Molecule to Mosquito

Control Etofenprox

“ee-toe-fen-procks”

Zenivex is a trademark of Wellmark International dba Central Life Sciences.©2008 Wellmark International.Always read and follow label directions.

Historic Moment for Mosquito Control• First NEW Active Ingredient for

Mosquito Control in Nearly 20 Years • EPA Classified as – Pyrethroid-Like

chemistry• EPA Designated as Reduced Risk

(Fast Track Registration)• Unique Molecule: Non-

Organophosphate, Non-Carbamate, Pyrethroid-Like

• Molecule Contains Only Carbon, Hydrogen, and Oxygen


Low Environmental Impact

• Highest LD50 - Least Oral Toxicity of Any Adulticide – Easing Public Concerns with Urban Ground/Aerial ULV

• Contains NO PBO - Eliminated Concerns about PBO

• Not Persistent in Soil, Water and Sediment- Rapid breakdown with a Half-life in Water 1.7 days, and Soil 4.4 days

• One of the Few Products approved for Control of Fleas and Mosquitoes on Cats


ETOFENPROX

PERMETHRIN


Etofenprox Mode of Action

• Similar mode of action to traditional pyrethroids

• Sodium channel blocker• Contact or ingestion toxicant• Quick knockdown


Etofenprox

0 10,000 20,000 30,000 40,000 50,000

Methoprene >34560

Resmethrin 4240

Sodium chloride 3000

Salicylic acid 1600Pyrethrins 1500Naled 435

Caffeine 335

Larger value = Least toxicity

Etofenprox >42,880

Oral LD50 (mg/kg) Rat

d-phenothrin >5,000


Zenivex™ Formulation

• 1.5 lb. Etofenprox per gallon

• 20% Etofenprox by weight

• 7.4 lbs/gal bulk density• Oil based formulation

for ULV: use either undiluted or diluted


Zenivex™ Formulation

• No synergist, that is, no PBO, no related concerns

• Packaged in 2.5 gallon jugs and 30 gallon drums

• Drums will use a closed dispensing system and will be returnable at users option


Zenivex™ Label Highlights• Application rates: 0.00175, 0.0035,

0.007 pounds etofenprox per acre• Aerial, vehicle mounted ground, or

hand applied applications• Droplet range for ground is 10-30

microns• Droplet range for aerial <60

microns• No aquatic setbacks• Signal word: Caution

– Non-Restricted use

Zenivex is a trademark of Wellmark International. ©2008 Wellmark International.Always read and follow label directions.

Zenivex™ Performance Species Evaluated to Date• Aedes aegypti

• Aedes albopictus• Aedes dorsalis• Aedes

melanimon• Aedes

nigromaculis• Aedes vexans• Anopheles

quadrimaculatus• Anopheles

crucian

• Coquillettidia sp.

• Culex nigripalpus

• Culex slinarius• Culex pipiens• Culex tarsalis• Culiseta

melanura• Ochlerotatus

nigromaculis• Ochlerotatus

sollicitans• Ochlerotatus

taeniorhynchus


Zenivex™ Efficacy Trials

• More than 30 trials have been conducted over a range of rates

• 17 mosquito species have been tested so far

• Trials have been conducted across the US– Northeast, Northwest, Southeast,

South and the West

• Good to Excellent results have been achieved at all label rates


Zenivex™ Efficacy Trials


Salt Lake Mosquito Abatement

Ground ULV Etofenprox TrialsAugust 12, 2008


Salt Lake Mosquito AbatementEtofenprox Trials ~ August 12, 2008


Species:Cx. tarsalis & Cx. pipiens

• Product Data– Application rate – 0.0035 lb.

AI/Acre– 2 parts BVA – 1 part Etofenprox– Flow rate 5.48 fl. oz./minute

• Vehicle Data– Phoenix Fogger VMD 18.5@ 1 psi– Truck speed 10 mph– Variable flow control

• Site Data– 4” cardboard constructed cage

nylon tulle screen– 20-25 mosquitoes per cage– 10-minute post application

mosquitoes transferred to clean holding cage

– Two cages per site– Spinning Impingers 1”-teflon

coated slides– 9-sites (3-100’ – 3-200’ – 3-300’

from ULV fogging truck)

• Meteorology– Spray start 9:25pm 340o @

2.8 knots 68o, 28% – Spray stop 9:26pm 340o @

2.8 knots 68o, 28% – Ten minutes post spray stop

time 340o @ 1 mph 68o, 28%

• Mosquitoes– Feral population –

Cx. Tarsalis & Cx. pipiens


Salt Lake City Mosquito Abatement District

0.0035 Pound Per Acre

0

20

40

60

80

100

Pe

rce

nt

100' 200' 300'Distance

1 hour

12 hour

24 hour


Chesapeake Mosquito Control Commission

Norfolk, Virginia

Ground ULV Etofenprox TrialsSeptember 18, 2008


Chesapeake Mosquito Control Commission – Norfolk, VirginiaGround ULV Etofenprox Trials ~ September 18, 2008


Species:Culex Quinquefasciatus


AI/Acre– Diluted BVA Oil 2 parts – 1 part

Etofenprox– Flow rate 5.48 fl. oz./minute

• Vehicle Data– Truck speed 10 mph– Variable flow control

• Site Data– 4” cardboard constructed cage

with nylon tulle screen– 20-25 mosquitoes per cage– 10-minute post application

mosquitoes transferred to clean holding cage

– Three cages per site– Spinning Impingers 1”-teflon

coated slides– 9-sites (3-100’ – 3-200’ – 3-300’

from ULV fogging truck)

• Meteorology– August 26, 2008 Trial– Start 6:21pm 30o @ 1.9

mph 53o, 78% • Mosquitoes

– Trial A: Culex quinquefasciatus

– Trial B: Mixed feral species• An. crucian• An. quacrimaculatus• Cs. melanura• Cx. erraticus• Cx. salinarius• Cs. territans• Oc. infirmatus• Ps. ciliata• Ps. ferox


Chesapeake Mosquito Control CommissionSeptember 18, 2008

020406080

100

Pe

rce

nt

100' 200' 300'Distance


1 hour

12 hour

24 hour

Culex quinquefasciatus


Chesapeake Mosquito Control CommissionSeptember 18, 2008

Mixed species

0

20

40

60

80

100

Pe

rce

nt

100' 200' 300'Distance


1 hour

12 hour

24 hour


Manatee County Mosquito ControlPalmetto, Florida

Ground ULV Etofenprox TrialsJune 3-4, 2008


Manatee County Mosquito Control, Palmetto, FloridaGround ULV Etofenprox Trials ~ June 3-4, 2008


Manatee County Mosquito Control, Palmetto, FloridaGround ULV Etofenprox Trials ~ June 3-4, 2008

Wind 61.5° Temp 25°C 57% RH


Species:Anopheles quadrimaculatus


AI/Acre– Dilutent BVA Oil– Uvitex fluorescence tracer– Flow rate 3.6 fl. oz./minute

• Vehicle Data– Vehicle speed 5 mph– London Fog 18-20: 15.8 MMD

• Site Data– WHO cages-transfer 25

mosquitoes per cage– Two WHO cages per site– Spinning Impingers 1-teflon

coated slides– 6-sites (3-50m – 3-100m from ULV

fogging truck)– Droplet collection rods for

fluorescence

• Meteorology– Spray start 23:27 61.5o @ 1

mph 25o C, 57% RH

• Mosquitoes– Colony reared – Anopheles

quadrimaculatus


Manatee County Mosquito Control, Palmetto, Florida


0

20

40

60

80

100

Per

cen

t

50 m 100 m

Distance

20 Minute % Knockdown

Trial A

Trial B


Manatee County Mosquito Control, Palmetto, Florida


0

20

40

60

80

100

Per

cen

t

50 m 100 m

Distance

24 hr Mortality

Trial A

Trial B


South Carolina

June 22-24, 2005• Target application rate 0.0035 lb.

AI/acre– (0.00346 – 0.00368)

• Flow rate 1 oz./minute• Natural population collections

– 85% Ochlerotatus taeniorhychus– 15% Ochlerotatus sollicitans


Mortality Summary – South Carolina20 minute % Knockdown


0102030405060708090

100P

erce

nt

50 m 100 m

Distance

Trial A

Trial B

Trial C

Trial D

Avg.


Mortality Summary – South Carolina24 hour % Mortalities


0102030405060708090

100P

erce

nt

50 m 100 m

Distance

Trial A

Trial B

Trial C

Trial D

Avg.

Avg. Ctrl.


Mortality Summary – South Carolina% Mortalities vs. % Knockdown


0102030405060708090

100P

erce

nt

50 m 100 m

Distance

Mortality

Knockdown

Zenivex™ Conclusion


• Zenivex™ is a proven addition to the toolbox for control of adult mosquitoes– Excellent control across the rate range– Effective on all mosquito species

tested• Low toxicity profile• No PBO synergist required• Quick, permanent knockdown• No odor• No aquatic setbacks• For use aerially and by ground• Proven performance used undiluted or

diluted


Special thanks to these and others:• Pasco County Mosquito Control District, FL• St. Tammany Parish Mosquito Control, LA• Georgetown County Mosquito Control, SC• Mosquito Research & Control Unit, Grand

Cayman• Manatee County Mosquito Control, FL• Orange County Mosquito Control, FL• Cascade County Mosquito Control, MT• Salt Lake City Mosquito Abatement, UT• Churchill County Mosquito Control, NV• Gem County Mosquito Abatement District, ID• Chesapeake Mosquito Control Commission, VA


For More Information

www.Altosid.comwww.zenivex.com

zenivex is a trademark of wellmark international dba central life sciences. ©2008 wellmark...

Documents

label directions

etofenprox methoprene

pounds etofenprox

new molecule

caribbeana new

control of fleas

oral toxicity

public concerns