zesperone + serlift

®

Alex Team Rana EL.Abd

®


Products sold in over 150 countries Over 3000 products 45 factories

© Sun Pharmaceutical Industries Limited. All Rights Reserved.

Active Constituent: Risperidone

Concentration : 2 mg – 4 mg

Use : Anti-psychotic

Route of administration : Oral

Dosage form : 10 Scored Tab

Price : 2 mg (30 L.E)

4 mg (45 L.E)

Zesperone®

Advantages

• More Selective in its action

• Less EPS

• No effect on prolactin

production

Zesperone®

7

FDA approval (Aug 2010)

(Clinical Antipsychotic Trial OF Intervention Effectiveness )

CATIE Study

Body Weight: Change from Baseline

0%10%20%30%40%

Risperidone Olanzapine

Glucose: Change from Baseline

0.0

5.0

10.0

15.0

Risperidone Quitapine Olanzapine

Wei

ght G

ain

>7%

Expo

sure

-Adj

uste

dM

ean

(mg/

dL)

Quitapine

Fasting Triglycerides: Change from Baseline

-20.0-5.010.025.040.0

RisperidoneExpo

sure

-Adj

uste

dM

ean

(mg/

dL)

Olanzapine


Active Constituent: Sertraline HCL

Concentration : 100 mg

Uses : Depression - OCD

Route of administration : Oral

Dosage form : Film coated tablets ( 10 Scored Tab )

Dose : 50mg/day ( may increases ) .. Max. 200 mg/day

Price : 40 L.E


1st Choice

Advantages

• More tolerated

• Less sedation

• Safe

• No CVS side effects

• No Atropine like effects

FDA approval (Feb 2007)

Published online January 29, 2009 DOI:10.1016/S0140-6736(09)60046-5Lancet

SSRIs Meta analysis in review



• 117 randomised trials

• 25,928 participants from 1991 up to Nov 30, 2007 .

• Treatment of unipolar major depression in adults using :

Bupropion, Citalopram, Duloxetine, Escitalopram, Fluoxetine,

Fluvoxamine,Milnacipran, Mirtazapine, Paroxetine, Reboxetine,

Sertraline, and Venlafaxine.

MethodologySSRIs Meta analysis in review



• Sertraline might be the best choice in depression treatment.

• The most favourable balance between benefit acceptability, and acquisition cost.

Findings



Thank YouRana ELabdTel : +91 22 6645 5645, Ext 000Tel Direct : +91 22 66455645Mobile : [email protected]

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zesperone + serlift

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