Z I N C - G LY C I N E C O M P L E X

A N T I - A G E I N G L I G H T E N I N G

( M E T A L L O T H I O N E I N E I N D U C E R )

The mineral and synthetic Zinc-Glycine Complex uses the Metallothioneine inductive ability of Zincand the ligand properties of Glycine for skin penetration.

This complex reduces the intracellular oxidative stress and synergistically potentiates a lightening effect through two metabolic pathways.

INCI: ZINC GLYCINATE

Reduces Intracellular Oxidative stress

Suppresses Melanocyte Stimulating Factors

Inhibits Tyrosinase activity

IN USE CONCENTRATION: 0,5 to 1%

(SKINCARE)

(FACE)

(NO ANIMAL TESTING)

CAS number : 14281-83-5 / Einecs : 238-173-1

%Cyclopentasiloxane ; PEG-10 Dimethicone ; Disteardimonium Hectorite 2,70

CyclomethiconeDC 345

NIKKOMULESE WO

DM 350TRIFAT S -308CIO

6,002,003,004,002,00

2,007,007,001,50

1,0060,50

0,70

0,60

DimethiconeTriethylhexanoinCetyl Ethylhexanoate

Butylene GlycolGlycerinTrisodium CitrateCitric AcidZinc GlycinateWater

HDI / PPG / Polycaprolactone Crosspolymer ; Silica

Macadamia Ternifolia Seed OilPhenoxyethanol ; Methylparaben ; Ethylparaben ;Butylparaben ; Isobutylparaben

MACADAMIA NUT OIL

A

DECABEN C

B PLASTIC POWDER CS 400BUTYLENE GLYCOLGLYCERINTRISODIUM CITRATECITRIC ACIDZINC - GLYCINE COMPLEX

C

WATER

Skin Lightening Cream

I N G R E D I E N T S I N C I

M A N U FA C T U R E P R O C E S S :

E VA L U AT I O NO N 3 DS K I N M O D E L

Disperse A (check no blocks of Nikkomulese WO).While dispersing, add B.Mix all ingredients of C and add it gradually.

2

1

3

UVB-irradiation (control) 100µM Zn(Gly)2 100µM ZnSO4

0

5.0

10.0

15.0

20.0

25.0

Cont. ZnCl210µM)

MT

(mg/

mg

prot

ein)

1 10 100

METALLOTHIONEINE INDUCTION

0.0

0.2

0.4

0.6

0.8

1.0

1.2

1.4

1.6

Cont ZnCl2 10 M

Ara

tio

offl

uore

scen

ceof

cont

rolc

ells

Zn(Gly)2 10 M

resistance against oxidative stressuvb-induced intracellularperoxidation (HaCaT keratinocytes)

MELANOCYTE GROWTH: -10% with 20 ppm Zn(Gly)2

TYROSINASE ACTIVITY: -40% with 0,02 ppm Zn(Gly)2

**

**

Zn(Gly)2

Without UVB irradiation 5 mJ/cm2 UVB irradiationConc.(µM)

10µM Zn(Gly)2 = 2ppm Zn(Gly)2 10µM Zn(Gly)2 = 2ppm Zn(Gly)2