zinc presentation1
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STUDY OF SERUM ZINC AND STUDY OF SERUM ZINC AND COPPER IN NEONATES AND COPPER IN NEONATES AND
THEIR MOTHERSTHEIR MOTHERS
Soumya Ranjan ParidaBasic B.Sc. Nursing 4th year
Sum Nursing College
ZINCZINC• Third most abundant trace element after
iron and fluorine.• Most abundant intracellular metal after
potassium and calcium.• Prosthetic group in metalloenzymes like
carbonic enhydrase and superoxide dismutase.
• Important for body growth & development of CNS & its myelination and bone mineralisation of fetus.
• Synthesis of DNA & RNA.• Helps in tissue repair and phagocytosis.
COPPERCOPPER• Essential part of cuproproteins.• Regulation of biological amines in
brain.• Prosthetic group in tyrosinase and
superoxide dismutase.
AIMS AND OBJECTIVESAIMS AND OBJECTIVES• 1.To find out level of zinc & copper in pregnant
women & their newborns at the time of delivery.
• 2.To find out relation between maternal serum zinc & copper status and serum zinc,copper status of their newborns.
• 3.To find out the correlation of these values with birth weight and gestational age.
• 4.To find out whether deficiency of these trace metals is associated with IUGR & prematurity.
Material and MethodsMaterial and Methods• The study group comprised 100 newborns
delivered in maternity ward of P.B.M. hospital,Bikaner and their mothers and 20 nonpregnant women to act as control.
• Excluding,neonates with perinatal complication affecting the physical & neurological status & newborns with evident congenital malformations.
• Method-atomic absorption spectrophotometry
MEAN SERUM MEAN SERUM ZINCZINC AND AND COPPERCOPPER LEVELS IN MATERNAL AND CORD LEVELS IN MATERNAL AND CORD
BLOODBLOOD
020406080
100120140160180
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MZ
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MATERNAL ZINCLEVEL
CORD SERUMZINC LEVEL
MATERNALCOPPER LEVEL
CORD SERUMCOPPER LEVEL
MEAN CORD SERUM MEAN CORD SERUM ZINCZINC AND AND COPPERCOPPER OF TERM AND PRETERM NEWBORNOF TERM AND PRETERM NEWBORN
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TERM SERUMZINC LEVEL
PRETERM SERUMZINC LEVEL
TERM SERUMCOPPER LEVEL
PRETERM SERUMCOPPER LEVEL
MEAN SERUM MEAN SERUM ZINCZINC AND AND COPPER COPPER LEVELS LEVELS OF OF TERMTERM NEWBORNS AND THEIR MOTHERS NEWBORNS AND THEIR MOTHERS
020
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MATERNALSERUM ZINCLEVEL
TERMNEWBORNSERUM ZINCLEVEL
MATERNALSERUM COPPERLEVEL
TERMNEWBORNSERUM COPPERLEVEL
RELATION OF CORD SERUM RELATION OF CORD SERUM ZINCZINC AND AND GESTATIONAL AGEGESTATIONAL AGE
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34 WKS -40 WKS
CO
RD
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M Z
INC
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mic
rog
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s/d
l
cord serumzinc level
RELATION OF CORD SERUM RELATION OF CORD SERUM ZINCZINC AND AND BIRTH WEIGHTBIRTH WEIGHT
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BIRTH WEIGHT(kg)
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M Z
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m
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ms/
dl
SERUM ZINCLEVEL
RELATION OF CORD SERUM RELATION OF CORD SERUM COPPER AND GESTATIONAL AGECOPPER AND GESTATIONAL AGE
05
10152025303540
30 33 36 39 42
GESTATIONAL AGE(WEEKS)
CO
RD
SER
UM
CO
PP
ER
LEV
EL(m
icro
gra
m/
dl)
RELATION OF CORD SERUM COPPER RELATION OF CORD SERUM COPPER AND BIRTH WEIGHTAND BIRTH WEIGHT
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1 1.5 2 2.5 3 3.5 4
BIRTH WEIGHT(KG)
CO
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(mic
rog
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/d
l)
MEAN CORD SERUM ZINC LEVEL IN MEAN CORD SERUM ZINC LEVEL IN RELATION TO INTRAUTERINE GROWTH RELATION TO INTRAUTERINE GROWTH
STATUS AT TERM AND PRETERMSTATUS AT TERM AND PRETERM
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CO
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UM
ZIN
C
LEV
EL(m
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gra
m/dl)
TERM AGATERM SGATERM LGAPRETERM AGAPRETERM SGA
MEAN CORD SERUM COPPERMEAN CORD SERUM COPPER LEVEL IN RELATION TO LEVEL IN RELATION TO INTRAUTERINE GROWTH STATUS AT TERM AND INTRAUTERINE GROWTH STATUS AT TERM AND
PRETERMPRETERM
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5
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50
CO
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UM
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EL(m
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ms/d
l)
TERM AGATERM SGATERM LGAPRETERM AGAPRETERM SGA
CONCLUSIONCONCLUSION• 1.Cord serum zinc level is higher than
maternal serum & copper level is lower.• 2.Prematurity is associated with lower
cord levels of serum zinc & copper levels.• 3.Our study has revealed that fetal
hypozincemia was associated with IUGR in our preterm group emphasising the importance of zinc in intrauterine growth of fetus.
• 4.Several trials have suggested reduction in preterm & LBW on zinc supplementation in mother.