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© ChromaCon AG // www.chromacon.ch // the CaptureSMB ® process principle 1 Contichrom ® animation - the CaptureSMB ® process principle -

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Page 1: © ChromaCon AG // // the CaptureSMB ® process principle 1 Contichrom ® animation - the CaptureSMB ® process principle -

© ChromaCon AG // www.chromacon.ch // the CaptureSMB® process principle 1

Contichrom® animation- the CaptureSMB® process principle -

Page 2: © ChromaCon AG // // the CaptureSMB ® process principle 1 Contichrom ® animation - the CaptureSMB ® process principle -

© ChromaCon AG // www.chromacon.ch // the CaptureSMB® process principle 2

Contichrom® & CaptureSMB® explained

Page 3: © ChromaCon AG // // the CaptureSMB ® process principle 1 Contichrom ® animation - the CaptureSMB ® process principle -

© ChromaCon AG // www.chromacon.ch // the CaptureSMB® process principle 3

Contichrom® & CaptureSMB® explained

Page 4: © ChromaCon AG // // the CaptureSMB ® process principle 1 Contichrom ® animation - the CaptureSMB ® process principle -

© ChromaCon AG // www.chromacon.ch // the CaptureSMB® process principle 4

Contichrom® & CaptureSMB® explained

Feed

column length

Internalconcentration

t1

t2t3

Feed

Wasted resin capacity in batch chromatography

Page 5: © ChromaCon AG // // the CaptureSMB ® process principle 1 Contichrom ® animation - the CaptureSMB ® process principle -

© ChromaCon AG // www.chromacon.ch // the CaptureSMB® process principle 5

Feed

Contichrom® & CaptureSMB® explained

Step 1:•Feed & wash

Step 2:•elute product•feed column

Step 3:•CIP & re-equil.•feed column

Page 6: © ChromaCon AG // // the CaptureSMB ® process principle 1 Contichrom ® animation - the CaptureSMB ® process principle -

© ChromaCon AG // www.chromacon.ch // the CaptureSMB® process principle 6

Feed

Contichrom® & CaptureSMB® explained

Step 1:•Feed & wash

Step 2:•elute product•feed column

Step 3:•CIP & re-equil.•feed column

Page 7: © ChromaCon AG // // the CaptureSMB ® process principle 1 Contichrom ® animation - the CaptureSMB ® process principle -

© ChromaCon AG // www.chromacon.ch // the CaptureSMB® process principle 7

Wash

Contichrom® & CaptureSMB® explained

Step 1:•Feed & wash

Step 2:•elute product•feed column

Step 3:•CIP & re-equil.•feed column

Page 8: © ChromaCon AG // // the CaptureSMB ® process principle 1 Contichrom ® animation - the CaptureSMB ® process principle -

© ChromaCon AG // www.chromacon.ch // the CaptureSMB® process principle 8

Elution

Contichrom® & CaptureSMB® explained

Feed

Product

Step 1:•Feed & wash

Step 2:•elute product•feed column

Step 3:•CIP & re-equil.•feed column

Page 9: © ChromaCon AG // // the CaptureSMB ® process principle 1 Contichrom ® animation - the CaptureSMB ® process principle -

© ChromaCon AG // www.chromacon.ch // the CaptureSMB® process principle 9

Contichrom® & CaptureSMB® explained

FeedCIP &

Re-equilibrationStep 1:•Feed & wash

Step 2:•elute product•feed column

Step 3:•CIP & re-equil.•feed column

Page 10: © ChromaCon AG // // the CaptureSMB ® process principle 1 Contichrom ® animation - the CaptureSMB ® process principle -

© ChromaCon AG // www.chromacon.ch // the CaptureSMB® process principle 10

Contichrom® & CaptureSMB® explained

Feed

Step 1:•Feed & wash

Step 2:•elute product•feed column

Step 3:•CIP & re-equil.•feed column

Page 11: © ChromaCon AG // // the CaptureSMB ® process principle 1 Contichrom ® animation - the CaptureSMB ® process principle -

© ChromaCon AG // www.chromacon.ch // the CaptureSMB® process principle 11

Contichrom® & CaptureSMB® explained

Wash

Step 1:•Feed & wash

Step 2:•elute product•feed column

Step 3:•CIP & re-equil.•feed column

Page 12: © ChromaCon AG // // the CaptureSMB ® process principle 1 Contichrom ® animation - the CaptureSMB ® process principle -

© ChromaCon AG // www.chromacon.ch // the CaptureSMB® process principle 12

Contichrom® & CaptureSMB® explained

Elution

Product

Feed

Step 1:•Feed & wash

Step 2:•elute product•feed column

Step 3:•CIP & re-equil.•feed column

Page 13: © ChromaCon AG // // the CaptureSMB ® process principle 1 Contichrom ® animation - the CaptureSMB ® process principle -

© ChromaCon AG // www.chromacon.ch // the CaptureSMB® process principle 13

Contichrom® & CaptureSMB® explained

CIP & Re-equil.

Feed

Start over

Step 1:•Feed & wash

Step 2:•elute product•feed column

Step 3:•CIP & re-equil.•feed column


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