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![Page 1: Copyright 2010 Digital Enterprise Research Institute. All rights reserved. Digital Enterprise Research Institute Solving Problems with Biology](https://reader030.vdocument.in/reader030/viewer/2022032723/56649d175503460f949ed722/html5/thumbnails/1.jpg)
Copyright 2010 Digital Enterprise Research Institute. All rights reserved.
Digital Enterprise Research Institute www.deri.ie
Solving Problems with Biology …via Linked Data
![Page 2: Copyright 2010 Digital Enterprise Research Institute. All rights reserved. Digital Enterprise Research Institute Solving Problems with Biology](https://reader030.vdocument.in/reader030/viewer/2022032723/56649d175503460f949ed722/html5/thumbnails/2.jpg)
Digital Enterprise Research Institute www.deri.ie
21st Century will be the Age of Biology
Climate Change
Nutritious Food
Sustainable Energy
Disease and Ageing
![Page 3: Copyright 2010 Digital Enterprise Research Institute. All rights reserved. Digital Enterprise Research Institute Solving Problems with Biology](https://reader030.vdocument.in/reader030/viewer/2022032723/56649d175503460f949ed722/html5/thumbnails/3.jpg)
Digital Enterprise Research Institute www.deri.ie
The most amazing molecule
4 letter code
2 chains, exact mirrors!
Same genetic code for all living cells!
- Adenosine
- Timine
- Citosine
- Guanine
- Adenosine
- Timine
- Citosine
- Guanine
Able to make copies of itself!
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Digital Enterprise Research Institute www.deri.ie
Making a human
![Page 5: Copyright 2010 Digital Enterprise Research Institute. All rights reserved. Digital Enterprise Research Institute Solving Problems with Biology](https://reader030.vdocument.in/reader030/viewer/2022032723/56649d175503460f949ed722/html5/thumbnails/5.jpg)
Digital Enterprise Research Institute www.deri.ie
Biology explained
![Page 6: Copyright 2010 Digital Enterprise Research Institute. All rights reserved. Digital Enterprise Research Institute Solving Problems with Biology](https://reader030.vdocument.in/reader030/viewer/2022032723/56649d175503460f949ed722/html5/thumbnails/6.jpg)
Digital Enterprise Research Institute www.deri.ie
Creating Synthetic Biology
Genetic engineering… oversimplified
DNA!
Bio-fuel producing gene
Biofuel
CO2
![Page 7: Copyright 2010 Digital Enterprise Research Institute. All rights reserved. Digital Enterprise Research Institute Solving Problems with Biology](https://reader030.vdocument.in/reader030/viewer/2022032723/56649d175503460f949ed722/html5/thumbnails/7.jpg)
Digital Enterprise Research Institute www.deri.ie
BioHacking = Do-it-yourself Biology by amateurs!
Bio
Bio
![Page 8: Copyright 2010 Digital Enterprise Research Institute. All rights reserved. Digital Enterprise Research Institute Solving Problems with Biology](https://reader030.vdocument.in/reader030/viewer/2022032723/56649d175503460f949ed722/html5/thumbnails/8.jpg)
Digital Enterprise Research Institute www.deri.ie
Executable Cell Biology
Cell and computers are not that different
Src
: htt
p:/
/gen
e-t
hera
py.
yola
site
.com
/pro
cess
.php
Activator genes
Repressor genes
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Digital Enterprise Research Institute www.deri.ie
Where does LD fit in all of this?
Let’s make a “virtual” experiment
Which gene?
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Digital Enterprise Research Institute www.deri.ie
?gene
biofuel
CO2
Non-toxic
Not-soluble H2O
![Page 11: Copyright 2010 Digital Enterprise Research Institute. All rights reserved. Digital Enterprise Research Institute Solving Problems with Biology](https://reader030.vdocument.in/reader030/viewer/2022032723/56649d175503460f949ed722/html5/thumbnails/11.jpg)
Digital Enterprise Research Institute www.deri.ie
Not that simple…
U de Lichtenberg et al. Science 2005;307:724-727
?sugar
Biofuel
? ?gene
?
?
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Digital Enterprise Research Institute www.deri.ie
The Linked Data Cloud“Life sciences will drive adoption of the Semantic Web, just as high-energy physics drove the early Web.” - BioIT World, 2005
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Digital Enterprise Research Institute www.deri.ie
Linked Data for Understanding Cancer
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Digital Enterprise Research Institute www.deri.ie
Link the Data, cure the disease
What your doctor is not telling you! Drugbank ClinicalTrialDiseasome
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Digital Enterprise Research Institute www.deri.ie
The diseasome project
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Digital Enterprise Research Institute www.deri.ie
Biosurveillance!! Today!
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Linked Data to track E. coli infection
UKE. coli
GermanyE. coli
![Page 18: Copyright 2010 Digital Enterprise Research Institute. All rights reserved. Digital Enterprise Research Institute Solving Problems with Biology](https://reader030.vdocument.in/reader030/viewer/2022032723/56649d175503460f949ed722/html5/thumbnails/18.jpg)
Digital Enterprise Research Institute www.deri.ie
Sou
rce:
htt
p:/
/ww
w.n
yti
mes.
com
/im
ag
ep
ag
es/
20
07
/01
/22
/sci
en
ce/2
00
70
12
3_S
CI_
ILLO
.ht
ml
Nothing in Biology Makes Sense Except in the Light of Evolution (Dobzhansky, 1973)
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Digital Enterprise Research Institute www.deri.ie
Toss the details, understand the patterns Navigating the genetic landscape with simplified
views
Source: http://www.sciencemag.org/content/327/5964/425.full
… IN THE CELL
IN CANCER OR …
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Digital Enterprise Research Institute www.deri.ie
Where is the data?
http://linkeddata.org
http://sindice.comhttp://www.w3.org/wiki/HCLSIG/LODD/Data
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Digital Enterprise Research Institute www.deri.ie
21st Century Biology belongs to BioHackers!