© nextpharma technologies 2006 nextpharma technologies experts in the production of pellets
TRANSCRIPT
© NextPharma Technologies 2006
What We Can Do For You
Formulation and Development of new products:Our Development Department is specialized in the development and formulation of new pellets and granule products. Its laboratory is specially equipped with the necessary technologies for this task.
Production:The production of aqueous and organic granules, extrudates and pellets, coating, tabletting and capsule filling of granules and pellets.
© NextPharma Technologies 2006
What We Can Do For You
Quality Control and Contract AnalysisModern and highly qualified laboratory for the analysis of all types of products (our specialist for the analysis of pellets), stability testing and development of analytical method.
© NextPharma Technologies 2006
Technologies
Granulation:Aqueous and organic granulation (high shear mixer and fluid bed granulation)
Extrusion / Spheronisation:For the production of homogeneous and organic extrudates and pellets
Coating:Aqueous or organic coating of granules and pellets
LayeringProduction of heterogeneous pellets using suspension-layering
© NextPharma Technologies 2006
Options for characteristics of produced pellets
Controlled ReleaseCan be achieved through:-Coating with special films (gastro resistant or pH independent diffusion film)-Difussion from Matrix-pellets
Odour or Taste MaskingBy coating the pellets with specific films in order to mask the unsuitable odour or taste
Colouring / FlavouringTo enhance the patient compliance / acceptance by coating the pellets with accordingly special layers
© NextPharma Technologies 2006
Production of pellets with extrusion / spheronisation
Blending & moisteningHigh shear mixer:Ring die press (extruder):
Extrusion
extrudate
SpheronisationSpheroniser:
moist pellets
CoatingKugelcoater:Fluid bed
dryer:Drying
© NextPharma Technologies 2006
Extrusion / Spheronisation Equipment
Blending & Moisting: Diosna P 400
© NextPharma Technologies 2006
Extrusion / Spheronisation Equipment
Fluid Bed Drying: Hüttlin HD 400
© NextPharma Technologies 2006
Production of pellets with suspension layering
Non-pareil
Layers with active substance
Spraying nozzle
Layers containing the active are sprayed onto non-pareils in a Kugelcoater (Bowl-coater)
© NextPharma Technologies 2006
Coating and Layering Equipment
Fluid Bed Coater and Granulator: Hüttlin HKC 300-TJ