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HEAT (Helicobacter Eradication Aspirin Trial) is a large scale outcomes study designed to see whether Helicobacter pylori eradication reduces the incidence of ulcer bleeding in aspirin users. It is being run by the University of Birmingham, with recruiting centres across the UK. It has received funding from the National Institute of Health Research (sponsored by University of Nottingham). The trial is very simple in design, and will involve very little work for GP practices. There are no follow-up visits for patients after their initial consent visit (which will be performed by our research nurses). Would you like to be involved in research? We’d really appreciate your help! We would be very grateful for your support and involvement in this study. Should you wish to find out more, please contact the University of Birmingham Research Facilitators Sarah Campbell (0121 414 3168 /[email protected] ) or Beth Hinks (0121 414 8545/[email protected] ) Alternatively, please complete the response slip below and fax it to 0121 414 2282. Many thanks and best wishes, Prof C Hawkey, University of Nottingham I would like to find out more about the HEAT trial! Practice name: ___________________________________________________________ Practice code: ___________________________________________________________ ADVANTAGES OF TAKING PART Research involvement at very little time cost to you Opportunity for developing research in your practice (GCP training available) Pragmatic simple trial to answer important questions Practice will be reimbursed: o for setting up the trial and inviting potential participants

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HEAT (Helicobacter Eradication Aspirin Trial) is a large scale outcomes study designed to see whether Helicobacter pylori eradication reduces the incidence of ulcer bleeding in aspirin users.

It is being run by the University of Birmingham, with recruiting centres across the UK. It has received funding from the National Institute of Health Research (sponsored by University of Nottingham).

The trial is very simple in design, and will involve very little work for GP practices . There are no follow-up visits for patients after their initial consent visit (which will be performed by our research nurses).

Would you like to be involved in research? We’d really appreciate your help!

We would be very grateful for your support and involvement in this study. Should you wish to find out more, please contact the University of Birmingham Research Facilitators Sarah Campbell (0121 414 3168 /[email protected]) or Beth Hinks (0121 414 8545/[email protected])

Alternatively, please complete the response slip below and fax it to 0121 414 2282.

Many thanks and best wishes,

Prof C Hawkey, University of Nottingham

I would like to find out more about the HEAT trial! Practice name: ___________________________________________________________

Practice code: ___________________________________________________________

Name: ___________________________________________________________

Role: ___________________________________________________________

Email: ___________________________________________________________

Phone: ___________________________________________________________

ADVANTAGES OF TAKING PART Research involvement at very little time cost to you Opportunity for developing research in your practice (GCP training available) Pragmatic simple trial to answer important questions Practice will be reimbursed:

o for setting up the trial and inviting potential participantso for room hire in your practice