1 chapter Ⅶ. the endocrine pancreas ps wang/ 2004.05
TRANSCRIPT
![Page 1: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/1.jpg)
1
Chapter Ⅶ. The Endocrine Pancreas
PS Wang/ 2004.05
![Page 2: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/2.jpg)
2
Islets of Langerhans (ovoid, 1-2% of the wt. of pancreas)
1. A cell (20%) glucagon catabolic, mobilizing glu., FFA & A.A. from stores into blood stream
2. B cell (>50%) insulin anabolic, increasing the storage of glu.
3. D cell (1-8%) somatostatin insulin, glucagon
4. No designation (few) pancreatic polypeptide function unknown
5. the fifth cell type
PS Wang/ 2004.05
![Page 3: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/3.jpg)
3
Yen & Jaffe 23-1 #240
![Page 4: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/4.jpg)
4
Hadley Endocrinology 1988 2nd ed #2007
![Page 5: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/5.jpg)
5
Ganong Review of Medical Physiology 2003 21st ed #256
![Page 6: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/6.jpg)
6
Ganong Review of Medical Physiology 1985 12th ed #258
![Page 7: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/7.jpg)
7
Ganong, W.F. Review of Medical Physiology 23rd Edition, ©2010 by The Mc Graw-Hill Companies, Inc.
![Page 8: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/8.jpg)
8
Modified from http://student.biology.arizona.edu/honors2003/group05/bg.html
Akt = protein kinase BGLUT-4 =Glucose transporter type 4IRS-1 = insulin receptor substrate-1
![Page 9: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/9.jpg)
9
Ganong Review of Medical Physiology 1985 12th ed #1428
![Page 10: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/10.jpg)
10
Hadley Endocrinology 1988 2nd ed #2008
![Page 11: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/11.jpg)
11
Hadley Endocrinology 1988 2nd ed #2009
![Page 12: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/12.jpg)
12
Ganong Review of Medical Physiology 2003 21st ed #259
![Page 13: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/13.jpg)
13
Ganong Review of Medical Physiology 2003 21st ed #156
![Page 14: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/14.jpg)
14
Ganong Review of Medical Physiology 2003 21st ed #1429
![Page 15: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/15.jpg)
15
Ganong Review of Medical Physiology 2003 21st ed #260
![Page 16: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/16.jpg)
16
#206
![Page 17: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/17.jpg)
17
Hadley Endocrinology 1988 2nd ed #2013
![Page 18: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/18.jpg)
18
#165
![Page 19: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/19.jpg)
19
Characteristics of Diabetes Mellites
polyuria, polydipsia (= excessive thirst),
weight loss in spite of polyphagia ( appetite)
hyperglycemia, glycosuria, ketosis, acidosis,
coma
PS Wang/ 2004.05
![Page 20: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/20.jpg)
20
Glucose Tolerance
If a glucose load is given to a diabetic, the blood glucose rises higher and returns to the baseline more slowly than it normally does
PS Wang/ 2004.05
![Page 21: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/21.jpg)
21
Chemistry ----1. polypeptide, 29 A.A.
2. MW = 3485
3. t1/2 = 5-10 min
4. synthesized from proglucagon
5. degraded by liverEffects ------ 1. glycogenolytic, gluconeogenic, lipolytic
2. stimulates adenylate cyclase (in liver) glycogen break down blood glucose
3. does not cause glycogenolysis in muscle 4. stiumlates the secretion of GH, insluin, SRIF
Regulation of secretion ---- 1. protein meal glucagon 2. starvation glucagon
Glucagon
PS Wang/ 2004.05
![Page 22: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/22.jpg)
22
#163
![Page 23: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/23.jpg)
23Hadley Endocrinology 1988 2nd ed #2010
![Page 24: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/24.jpg)
24Ganong Review of Medical Physiology 2003 21st ed #158
![Page 25: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/25.jpg)
25Ganong Review of Medical Physiology 2003 21st ed #157
![Page 26: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/26.jpg)
26Hadley Endocrinology 1988 2nd ed #2012
![Page 27: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/27.jpg)
27
Ganong Review of Medical Physiology 1999 19th ed #160
![Page 28: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/28.jpg)
28
Human DiabetesJuvenile Diabetes :
onset in childhood or adolescene frequently ketoacidosis B cell disorders pancreatic insulin content is low
Maturity Diabetes : onset in adult (obese people) ketoacidosis is rare B cell morphology is normal pancreatic insulin content is normal
PS Wang/ 2004.05
![Page 29: 1 Chapter Ⅶ. The Endocrine Pancreas PS Wang/ 2004.05](https://reader035.vdocument.in/reader035/viewer/2022062721/56649f1c5503460f94c32f40/html5/thumbnails/29.jpg)
29
Tepperman & Tepperman Metabolic and Endocrine Physiology 1997 5th ed #1239