1 organic components (e.g. collagen) inorganic components (e.g., calcium and phosphate) 65-70% (dry...
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Organic Components(e.g. collagen)
Inorganic Components(e.g., calcium and phosphate)
65-70%(dry wt) H2O
(25-30%)
one of the body’s hardest
structuresviscoelastic
ductile
brittle
Biomechanical Characteristics of Bone - Bone Tissue
25-30%(dry wt)
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Strength and Stiffness of Bone Tissue
evaluated using relationship between applied load and amount of deformation
LOAD - DEFORMATION CURVE
Bone Tissue Characteristics
Anisotropic Viscoelastic Elastic Plastic
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Stress = Force/Area Strain = Change in Length/Angle
Note: Stress-Strain curve is a normalized Load-Deformation Curve
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elasticregion
plastic regionfracture/failure
Str
ess
(Lo
ad)
Strain (Deformation)
stressstrain
Elastic & Plastic responses
•elastic thru 3%deformation
•plastic response leads to fracturing
•Strength defined by failure point
•Stiffness defined as the slope of the elastic portion of the curve
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Elastic Biomaterials (Bone)
•Elastic/Plastic characteristics
Brittle material fails before permanent deformation
Ductile material deforms greatly before failure
Bone exhibits both properties
Load/deformation curves
deformation (length)
load ductile material
elasticlimit
bone
brittle material
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Anisotropic response behavior of bone is dependent on direction of applied load
Bone is strongest alonglong axis - Why?
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fracture
fracture
fast
slow
Lo
ad
deformation
Viscoelastic Response behavior of bone is dependent on rate load is applied
Bone will fracture soonerwhen load applied slowly
8Compression Tension Shear Torsion Bending
Mechanical Loading of Bone
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Vertebral fracturescervical fracturesspine loaded through heade.g., football, diving, gymnastics once “spearing” was outlawed in football the number of cervical injuries declined dramatically
lumbar fracturesweight lifters, linemen, or gymnastsspine is loaded in hyperlordotic(aka swayback) position
Compressive Loading
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Tensile Loading
Main source of tensile load is muscle
tension can stimulate tissue growth
fracture due to tensile loading is usually an avulsionother injuries include sprains, strains, inflammation, bony deposits
when the tibial tuberosity experiences excessive loads from quadriceps muscle group develop condition known as Osgood-Schlatter’s disease
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Shear Forces
created by the application of compressive, tensile or a combination of these loads
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Relative Strength of Bone
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Usually a 3- or 4-pointforce application
Bending Forces
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Torsional Forces Caused by a twistingtwisting forceproduces shear, tensile, and compressive loads
tensile and compressive loads areat an angle
often see a spiral fracture developfrom this load
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• axial skeleton– skull, thorax, pelvis, &
vertebral column
• appendicular skeleton– upper and lower
extremities
• should be familiar with all major bones
SKELETON
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Purposes of Skeleton
• protect vital organs
• factory for production of red blood cells
• reservoir for minerals
• attachments for skeletal muscles
• system of machines to produce movement in response to torques
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Bone Vernacular
• condyle– a rounded process of a bone that
articulates with another bone• e.g. femoral condyle
• epicondyle– a small condyle
• e.g. humeral epicondyle
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Bone Vernacular
• facet– a small, fairly flat, smooth surface of a
bone, generally an articular surface• e.g. vertebral facets
• foramen– a hole in a bone through which nerves or
vessels pass• e.g. vertebral foramen
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Bone Vernacular• fossa
– a shallow dish-shaped section of a bone that provides space for an articulation with another bone or serves as a muscle attachment
• glenoid fossa
• process– a bony prominence
• olecranon process
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Bone Vernacular
• tuberosity– a raised section of bone to which a
ligament, tendon, or muscle attaches; usually created or enlarged by the stress of the muscle’s pull on that bone during growth
• radial tuberosity
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Long Bones• e.g. femur, tibia
• 1 long dimension
• used for leverage
• larger and stronger in lower extremity than upper extremity– have more weight to
support
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Short Bones
• e.g. carpals and tarsals
• designed for strength not mobility
• not important for us in this class
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Flat Bones
• e.g. skull, ribs, scapula
• usually provide protection
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Irregular Bones
• e.g. vertebrae
• provide protection, support and leverage
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• e.g. patella (knee cap)
• a short bone embedded within a tendon or joint capsule
• alters the angle of insertion of the muscle
Sesamoid Bones
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Long Bone Structure
cortical or compact bone (porosity ~ 15%) periosteum outer cortical membrane endosteum inner cortical membrane
trabecular, cancellous,or spongy, bone (porosity ~70%)
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Long Bone Structureepiphyseal platecartilage separating metaphysis from epiphysis
epiphysisproximal and distal ends of a long bone
metaphysiseither end of diaphysisfilled with trabecular bone
diaphysis shaft of bone
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Biomechanical Characteristics of Bone
Bone TissueRemodeling/Growth
Physical Activity Lack of Activity
Bone Deposits(myositis ossificans)
Age &Osteoporosis
Gravity Hormones
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Longitudinal Bone Growth
– occurs at the
epiphyseal or
“growth “ plate– bone cells are produced on the
diaphyseal side of the plate– plate ossifies around age 18-25 and
longitudinal growth stops
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Circumferential Bone Growth
– growth throughout the
lifespan– bone cells are produced on the
internal layer of the periosteum by osteoblasts
– concurrently bone is resorbed around the circumference of the medullary cavity by osteoclasts
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Wolff’s Law
• bone is laid down where needed and resorbed where not needed
• shape of bone reflects its function– tennis arm of pro tennis players have
cortical thicknesses 35% greater than contralateral arm (Keller & Spengler, 1989)
• osteoclasts resorb or take-up bone
• osteoblasts lay down new bone
Biomechanical Characteristics of Bone
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Bone Deposits• A response to regular activity
– regular exercise provides stimulation to maintain bone throughout the body
– tennis players and baseball pitchers develop larger and more dense bones in dominant arm
– male and female runners have higher than average bone density in both upper and lower extremities
– non-weightbearing exercise (swimming, cycling) can have positive effects on BMD
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Bone Resorption
• lack of mechanical stress– Calcium (Ca) levels decrease– Ca removed through blood via kidneys
• increases the chance of kidney stones
• weightless effects (hypogravity)– astronauts use exercise routines to provide
stimulus from muscle tension• these are only tensile forces - gravity is compressive
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Typical Vertical GRF during running
0
5
10
15
20
25
30
0 50 100 150 200 250 300
time (ms)
Fz
(N/k
g)
Heel-toe running pattern
Tip-Toe running pattern
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TVISTreadmill Vibration Isolation andStabilization System
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Changes in bone over timeEarly Years
• Osgood-Schlatter’s disease• development of inflammation, bony deposits, or an
avulsion fracture of the tibial tuberosity
• muscle-bone strength imbalance• “growth factor” between bone length and muscle
tendon unit (e.g., rapid growth of femur and tibia places large strain on patellar tendon and tibial tuberosity)
• during puberty muscle development (testosterone) may outpace bone development allowing muscle to pull away from bone
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Changes in bone over timeEarly Years
• overuse injuries– repeated stresses mold skeletal structures
specifically for that activity– Little Leaguer’s Elbow
• premature closure of epiphyseal disc
– Gymnasts• 4X greater occurrence of low back pathology in
young female gymnasts than in general population (Jackson, 1976)
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Changes in bone over timeAdult Years
• little change in length
• most change in density– lack of use decreases density
• DECREASE STRENGTH OF BONE
• activity– increased activity leads to increased
diameter, density, cortical width and Ca
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Changes in bone over timeAdult Years
• hormonal influence– estrogen to maintain bone minerals– previously only consider after menopause– now see link between amenorrhea and
decreased estrogen - Female Athlete Triad
osteoporosisdisorderedeating
amenorrhea
low body fatexcessive training
low estrogenlevels
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Changes in Bone Over TimeOlder Adults
• 30 yrs males and 40 yrs females– BMD peaks (Frost, 1985; Oyster et al., 1984)
– decrease BMD, diameter and mineralization after this
• activity slows aging process
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Osteoporosis
HormonalFactors
NutritionalFactors
PhysicalActivity
OsteopeniaReduced BMD
slightly elevated risk of fracture
Severe BMD reductionvery high risk of
fracture(hip, wrist, spine, ribs)
28 million Americans affected – 80% of these are women10 million suffer from osteoporosis
18 million have low bone mass
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Osteoporosis
• age– women lose 0.5-1% of their bone mass
each year until age 50 or menopause– after menopause rate of bone loss
increases (as high as 6.5%)
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Do you get shorter with age?• Osteoporosis compromises structural
integrity of vertebrae– weakened trabecular bone– vertebrae are “crushed”
• actually lose height• more weight anterior to spine so the compressive
load on spine creates wedge-shaped vertebrae – create a kyphotic curve known as Dowager’s Hump
• for some reason men’s vertebrae increase in diameter so these effects are minimized
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Preventing Osteoporosis
• $13.8 billion in 1995 (~$38 million/day)• Lifestyle Choices
– proper diet• sufficient calcium, vitamin D,• dietary protein and phosphorous (too much?)• tobacco, alcohol, and caffeine
– EXERCISE, EXERCISE, EXERCISE• 47% incidence of osteoporosis in sedentary population
compared to 23% in hard physical labor occupations (Brewer et al., 1983)
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Osteoporosis, Activity and the Elderly
Rate of bone loss (50-72 yr olds, Lane et al., 1990)4% over 2 years for runners6-7% over 2 years for controls
However - rate of loss jumped to 10-13% after stopped running
suggest substitute activities should providehigh intensity loads, low repetitions (e.g. weight lifting)
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Injury - Repetitive v. Acute Loading
frequency of loading
mag
nitu
de o
f lo
adin
g
injury tolerance(above this line injury will occur)
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Articulations
• junction of 2 bones
• MOTION OCCURS AT A JOINT -- NOT AT A LIMB– i.e. elbow flexion NOT forearm flexion
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Classification of joints
• Synarthroses - fibrous joint with little or no movement
• Amphiarthroses - cartilaginous joints with some motion
• Diarthroses - (aka synovial) - freely movable joint
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Joint Classification
• based on – number of axes of rotation– number of planes of motion– e.g. uniaxial -- 1 axis of rotation so 1 plane
of motion
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Condyloid = Biaxiale.g., flexion & extension
internal & external rotation
Ball and Socket = Triaxiale.g., flexion & extension
internal & external rotationabduction & adduction
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Hinge = uniaxiale.g., flexion and extension
Pivot = uniaxiale.g., supination& pronation
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Gliding = no axes‘gliding between
2 flat bones’
Saddle = biaxialsame as condyloidbut greater ROM
Ellipsoidal = biaxiale.g., flexion & extensionabduction & adduction
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Structure of Synovial Joint
A - articular (hyaline) cartilage (1-7 mm)– smooth elastic tissue on
ends of bone– 60-80% water– no blood supply– absorbs shock,
distributes force and provides a low friction surface
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Structure of Synovial JointB - fibrous capsule
– very fibrous collagen tissue used to hold bones together
C - synovial membrane– lines the joint cavity– secretes synovial fluid to
lubricate and provide nutrition
NOTE: B & C combine to form the articular capsule
or joint capsule
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Structure of Synovial Joint
D - ligaments– connect bone-to-bone– usually restrict ROM
at a joint
• tendons (not shown)– connect muscle-to-
bone
A* - Joint cavity
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Other Structures of Synovial Joints
• bursa– small capsules lined with
synovial membranes– reduces friction between other
structures in the joint
• tendon sheaths– fascia surrounding tendon to
reduce friction between tendon and surrounding structures
Olecranon bursa
Digital synovial sheath
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Other Structures of Synovial Joints
articular fibrocartilage – different from articular cartilage– takes the form of a
fibrocartilaginous disc or partial disc• distributes load over joint surface• improve fit of articulating surfaces• limit slipping of one bone relative to
other• protect periphery of articulation• lubricate articulation• absorb shock
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Arthritis• Refers to more than 100 different diseases that affect areas in or around joints.
• The disease also can affect other parts of the body.
• Arthritis causes pain, loss of movement and sometimes swelling.
•Affects women more than men
Source: Arthritis Foundation – www.arthritis.org
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Arthritis
Osteoarthritis20.7 million
Mostly after age 45Rheumatoid2.1 million
Mostly women
Fibromyalgia3.7 million
Mostly women
Gout2.1 million
Mostly men
Spondylarthropathies412,000
JuvenileArthritis285,000
Under age 17
Juvenile RheumatoidArthritis (JRA)
50,000 Lupus239,000
Source: Arthritis Foundation – www.arthritis.org
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Osteoarthritis (OA), or degenerative joint disease, is one of the oldest and most common types of arthritis, characterized by the breakdown of the joint's cartilage. Cartilage is the part of the joint that cushions the ends of bones. Cartilage breakdown causes pain and joint swelling. With time, there will be limited joint movement.
• Most commonly affects middle-aged and older people
• Range from very mild to very severe
• Affects hands and weight-bearing joints (e.g., knees, hips, feet and back).
• OA is not an inevitable part of aging, although age is a risk factor
• Obesity may lead to osteoarthritis of the knees
• Joint injuries due to sports, work-related activity or accidents may be at increased risk of developing OA.
Source: Arthritis Foundation – www.arthritis.org
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• Characterized by the inflammation of the membrane lining the joint, which causes pain, warmth, redness and swelling.
• The inflamed joint lining, the synovium, can invade and damage bone and cartilage.
• Inflammatory cells release enzymes that may digest bone and cartilage.
• The involved joint can lose its shape and alignment, resulting in pain and loss of movement.
• The disease usually begins in middle age, but can start at any age, and affects two to three times more women than men.
Rheumatoid Arthritis (RA) – a systemic disease that affects the entire body.
Source: Arthritis Foundation – www.arthritis.org
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Fibromyalgia syndrome is a condition with generalized muscular pain and fatigue that is believed to affect approximately 3.7 million people.
Location of “Tender Points”
• The name fibromyalgia means pain in the muscles and the fibrous connective tissues (the ligaments and tendons). The condition is known as a syndrome because it is a set of signs and symptoms that occur together.
• Fibromyalgia mainly affects muscles and their attachments to bones. Although it may feel like a joint disease, it is not a true form of arthritis and does not cause deformities of the joints. Fibromyalgia is, instead, a form of soft tissue or muscular rheumatism.
Source: Arthritis Foundation – www.arthritis.org
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Arthritis Treatments
Medicines(e.g., analgesics, NSAIDS,
DMARDS, Disease ModifyingAnti-Rheumatic Drugs)
Physical/Occupational Therapy• recommend and teach prescribed muscle strengthening and range-of-motion exercises• teach non-medication ways to control pain• suggest ways to make everyday and work activities easier
RestMore rest and less activity are needed during flares and the
opposite is true during periods of improvement.
Surgeryjoint replacement
Use of Heat or ColdHelpful before and after exercise
Many respond better to cold packs than to heat
Use of Heat or ColdHelpful before and after exercise
Many respond better to cold packs than to heat
Diet• Lack of vitamins associated with progression of OA of the knee • Connection between obesity and OA of the knee• Diet high in Omega 3 fatty acids may help reduce inflammation in RA• In general, people with arthritis are urged to maintain a balanced diet and stay close to their ideal weight.
Joint ProtectionCareful use of joints to limit the pressure on the
involved jointSimple and inexpensive devices available
Exercise(see next slide)
Source: Arthritis Foundation – www.arthritis.org
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Exercise• Proper exercises performed on a daily basis are an important part of arthritis treatment.
• Exercise to help reduce weight can help prevent osteoarthritis in the knee.
• Proper exercise helps build and preserve muscle strength, keep joints flexible and help protect joints from further damage.
Two categories of exercise:
• Therapeutic -- Prescribed by a doctor, physical therapist or an occupational therapist. These exercises are based on individual needs and are designed to reach a certain goal.
• Recreational -- Includes any forms of movement, amusement or relaxation that refreshes the body and mind. These exercises add to a therapeutic program, but do not replace it.
Three types of exercises:
•Range-of-motion -- Moving a joint as far as it comfortably will go and then stretching it a little further. Range-of-motion exercises are designed to increase and maintain joint mobility that will decrease pain and improve function.
•Strengthening -- Increases muscle strength to stabilize weak joints. These exercises use the muscle without moving the joint.
•Endurance -- This type of exercise includes walking, swimming, bicycling, jogging, dancing and skiing. These dynamic forms of exercise increase endurance, whereas range-of-motion and strengthening do not. The most common risk in exercising is injury to joints and muscles. This usually happens from exercising too long or too hard, especially if a person has not been active for some time.
Source: Arthritis Foundation – www.arthritis.org
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close packed position– maximum contact
area
– minimum mobility
– maximum stability
close-packed vs. loose packed
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Bony Stability (cont.)
• amount of contact area
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Joint Stability - Connective Tissue
• ligamentous support
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Properties of Connective Tissue
• elasticity– ability to return to normal state after stretch– elastic limit
• stretch beyond this limit will cause permanent damage
• plasticity– stretched too far such that does not return to
its normal state• ligament sprain (worse than bone fracture)
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deformation (length)
load
elas
tic
plastic
elasticlimit
Sprains occur in this region
Sprains resultin decrease ofjoint stability
Exercisewill helpincreasethe loadsa ligamentor tendoncan sustain
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Joint Stability - Muscles
• muscular arrangement– ability of muscle to
provide support– muscle fatigue
• cruciate rupture more likely when muscle is fatigued
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Mobility
• degree to which an articulation is allowed to move before being restricted by surrounding tissues
• ROM a.k.a. flexibility
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Stability v. Mobility
• trade-off between stability and mobility
–increase stability decrease mobility
–vice-versa