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PLEASING CLIENTS AT A MOLECULAR AND CELLULAR LEVEL

AUGUST 7, 2015

We live in a society exquisitely dependent on science and technology, in which hardly anyone knows anything about science and technology.

– Carl Sagan (1990)

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TOPICS FOR DISCUSSION

Pace of life sciences1

Demands of the domain2

Multi-faceted and interdisciplinary business of science3

Focus on the customer: PDS in biotech4

Industry challenges & beyond5

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SCIENCE DOMAIN: CHAOS & CHANGE

Science TechnologyHypotheses

ThroughputAnalyses

Conclusions

Ideas

Experiments

Data

Algorithms

MethodsAnd everyone is going through the process differently…

Models

Data Management

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• Improvements in technology• Increase in amount of data• Development of algorithms

EVOLVING WITH THE PROCESS

Sample handling

Sample processing

Data storage

Data analysis

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DURATION 10+ YEARS

TECHNOLOGY IS RACING FORWARD, BUT DRUG DEVELOPMENT CYCLE IS LONG

LEAD IDENTIFICATION

PRE-CLINICAL CLINICAL TRIALS

PHASE I PHASE II PHASE III

FDA REVIEW

3-6 YRS 6-7 YRS 1-2 YRS

MANY COMPOUNDS

250 COMPOUNDS

20-100 VOLUNTEERS

100-500 VOLUNTEERS

1,000-5,000 VOLUNTEERS

ONE APPROVED

DRUG

? YRS

TARGET ID &

VALIDATION

Genomics ProteomicsTranscriptomics Epigenomics

ChemistryMetabolomicsToxicity

And all that data has to be “handled”!

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DURATION >10 YEARS

TECHNOLOGY IS RACING FORWARD, BUT CYCLE OF DRUG DEVELOPMENT IS LONG

LEAD IDENTIFICATION

PRE-CLINICAL CLINICAL TRIALS

PHASE I PHASE II PHASE III

FDA REVIEW

3-6 YRS 6-7 YRS 1-2 YRS

MANY COMPOUNDS

250 COMPOUNDS

20-100 VOLUNTEERS

100-500 VOLUNTEERS

1,000-5,000 VOLUNTEERS

ONE APPROVED

DRUG

? YRS

TARGET ID &

VALIDATION

Genomics ProteomicsTranscriptomics Epigenomics

ChemistryMetabolomicsToxicity

LEAD IDENTIFICATION

PRE-CLINICAL

3-6 YRS

MANY COMPOUNDS

250 COMPOUNDS

? YRS

TARGET ID &

VALIDATION

The greatest improvement to this cycle’s efficiency can be achieved

before the clinical phase

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THE LIFE SCIENCES MILIEU

ChemistryEngineering

Regulatory

ClinicalAnimal Sciences

Biology

Informatics

FinanceOperations

IT

Legal

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• Scientists and their habits• Reconciling business & science• Need someone to:

• Keep everyone focused• Suggest methods• Make workflows easy• Do it fast!

FROM SPREADSHEETS TO SYSTEMS: GETTING USERS ONBOARD

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FOCUS ON THE CUSTOMER: DELIVERING ON THE PROMISE OF PDS

DirectionIdentify direction of the business

ScienceNovel technologies speed up the science

TechnologiesBring novel technologies to the business

BusinessScience drives business forward

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SYSTEM TO ACCELERATE & OPTIMIZE DRUG DESIGN

https://www.youtube.com/watch?v=HjB536Glvpw

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• Covers the process

• Open for integration

• With scientific context

• Allows integrated questions to be posed

A PRODUCT: DRUG DESIGN STUDIO

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SYSTEM TO ACCELERATE & OPTIMIZE DRUG DESIGN

https://www.youtube.com/watch?v=vR3nauEkiuI

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For specific business need

To be used across disciplines

With best scientific practices

AT THE END OF THE DAY: PRODUCT BUILT

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We have software that captures & searches data.The Question is “What’s next?”

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ONE STEP BEYOND

http://telemedicina.med.muni.cz/

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SOLUTIONS FOR THE BIOTECH BUSINESS

CLIENTWhat do I do with the petabytes of

chemistry, biology, modeling, in-vivo, clinical data?

Provide system for data tracking & integration

How do I search it?Develop search algorithms that allow

omni-directional information flow across disciplines

What can I do with it? Develop analysis algorithms and visualization tools

EPAM

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EXAMPLE: ELECTRONIC NOTEBOOK

• GOOD:

• Searchable• Achievable

• BAD:

• Organization• Data extraction • Visualization

• Need: Different notebooks for different disciplines (modular) with common back end and visualization layer

Biologists

Chemists

Informaticists

Clinicians

Animal Scientists

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Onsite team must speak client’s language

TO ACHIEVE SUCCESS WITH CUSTOMER, REMEMBER:

Business Technology

Science

EPAM Team

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THANKS TO

Thank You!

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