10. immune response part 1 (reupload)

8/13/2019 10. Immune Response Part 1 (Reupload)

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Assoc. Prof. Ma. Jennifer R. Tiburcio,MSMT

Department of Med Tech

UST Faculty of Pharmacy


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Immune responsehos t react ion to a foreign substance ant igen

humora l

cel lu lar

tolerance


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Fate of the ant ig en

Mode of entry Site of Ag trapping

Ingested/Inhaled Peyers patches

Intestinal mucosa

Alveolar liningIntracutaneous/ Regional lymph node

Subcutaneous

Intravenous/ SpleenIntraperitoneal


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Regardless of the route of administration

macrophagespivotal role

present the Aglymphoid cells

in phagocytosis

function as effector cellsrecognize, engulf &destroy the Ags

accessory cells

major APCs


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Processing of exogenous Ags in association w/

MHC II molecules

1. Phagocytosis or endocytosis of antigen

2. Digestion of antigen into peptide fragments (APC)

3. Fusion of vesicles containing peptide fragments and

MHC II molecules

4. Peptide fragments bind to MHC II molecules

5. Vesicle undergoes exocytosis and Ag-MHC II

complexes are inserted into the membrane


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Processing of Ags in association with MHC I

Molecules1. Class I molecules bind peptides that have been synthesized within

the cell --- viral proteins

2. Peptides from degraded viral proteins are transported into the

endoplasmic reticulum

3. Partially folded MHC I molecules bound by calnexin meets viralpeptide in the ER

4. Peptide binding completes MHC I folding releasing calnexin; only

folded molecules are exported to the Golgi apparatus

5. Bound viral peptide is carried by MHC class I to the cell surface


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Collaboration among cells

Humoral

T helper, B cell & macrophage

B cell undergoes blastogenesis & differentiation under

the influence of various cytokines(intracellular adhesion molecules)

Cellular

T helper, Tcell precursor & macrophage


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Activation of T cells

1. TH&

TDTHpresentation of Ag with MHC class II

CD28 on the T cell binding to B7 on APC

2. TCTCR-CD8 & MHC Class II

release of interleukins3. TSAg appears to be capable of directly activating

TS cells


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Activation of B cells

1. Provided by the interactions between Ag and B cell Igreceptor

2. Contact between T helper cells & B cells mediated by

soluble materials released from T helper cells

3. Various interleukins (BCGF) also affect B cell

proliferation & maturation

Additional adhesion molecules important in cell

activation

CD28T cells

B7 (also BB1)B cells


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10. immune response part 1 (reupload)

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