1,000 compounds 15 hits · out of 1,000 compounds screened, 15 were active hits. why use 3d over...

3D CELL CULTURE IS CHANGING THE GAME. The research tool can show a more biologically relevant picture of how cells function on many levels. 3D BY THE NUMBERS The number of publications using 3D cell culture has nearly tripled over the past 5 years. THE DEMAND FOR 3D CELL CULTURE Because of these benefits, the 3D cell culture market is expected to more than triple in size by 2024. 3D MODELING: FLASHBACK TO THE 80S In the 1980s, the Bissell lab began using 3D cell models to study how breast cancer is influenced by signaling pathways in the tumor microenvironment. DRUG DISCOVERY IN ACTION In a recent study, a 3D organotypic model of ovarian cancer identified smaller molecules that inhibited ovarian cancer cell adhesion, migration and invasion. Out of 1,000 compounds screened, 15 were active hits. WHY USE 3D OVER 2D? 3D organotypic culture models (such as organoids and spheroids) are better than 2D models because they: ü create cellular interactions that mimic scenarios in vivo; ü exhibit a higher degree of structural complexity and homeostasis, similar to tissues and organs; and ü provide accurate predictions of drug efficacy and toxicity, along with an understanding of a drug’s mechanism of action. VISUALIZE THE FULL DETAIL OF 3D CELL CULTURE WITH HIGH CONTENT ANALYSIS PerkinElmer offers a full product portfolio for 3D applications that includes spheroid culture platforms, reagents for metabolic analysis, and premier high content analysis and screening imaging platforms. Study the cell’s vascular system Learn how cells communicate and interact with each other Avoid sacrificing animals for models in preclinical studies See how cells migrate, differentiate, survive and grow Source: Grand View Research, Inc. perkinelmer.com/3Danalysis Observe phenotypic changes in detail THE KEYS TO 3D 3D CELL CULTURE: COMING TO A LAB NEAR YOU 1,000 compounds 15 hits 672 785 1040 1400 1630 2011 2012 2013 2014 2015 CORE BENEFITS They also allow researchers to: 2013 Cancer 500 1000 USD million 1500 2000 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 Tissue engineering & immunohistochemistry Drug development Stem cell research Others

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Page 1: 1,000 compounds 15 hits · Out of 1,000 compounds screened, 15 were active hits. WHY USE 3D OVER 2D? 3D organotypic culture models (such as organoids and spheroids) are better than

3D CELL CULTURE IS CHANGING THE GAME.The research tool can show a more biologically relevant picture of how cells function on many levels.

3D BY THE NUMBERSThe number of publications using 3D cell culture has nearly tripled over the past 5 years.

THE DEMAND FOR 3D CELL CULTUREBecause of these benefits, the 3D cell culture market is expected to more than triple in size by 2024.

3D MODELING: FLASHBACK TO THE 80SIn the 1980s, the Bissell lab began using 3D cell models to study how breast cancer is influenced by signaling pathways in the tumor microenvironment.

DRUG DISCOVERY IN ACTIONIn a recent study, a 3D organotypic model of ovarian cancer identified smaller molecules that inhibited ovarian cancer cell adhesion, migration and invasion. Out of 1,000 compounds screened, 15 were active hits.

WHY USE 3D OVER 2D?3D organotypic culture models (such as organoids and spheroids) are better than 2D models because they:

ü create cellular interactions that mimic scenarios in vivo;

ü exhibit a higher degree of structural complexity and homeostasis, similar to tissues and organs; and

ü provide accurate predictions of drug efficacy and toxicity, along with an understanding of a drug’s mechanism of action.

VISUALIZE THE FULL DETAIL OF 3D CELL CULTURE WITH HIGH CONTENT ANALYSIS

PerkinElmer offers a full product portfolio for 3D applications that includes spheroid culture platforms, reagents for metabolic analysis, and premier high

content analysis and screening imaging platforms.

Study the cell’s vascular system

Learn how cells

communicate and interact

with each other

Avoid sacrificing animals for models in preclinical studies

See how cells migrate, differentiate, survive

and grow

Source: Grand View Research, Inc.

perkinelmer.com/3Danalysis

Observe phenotypic

changes in detail