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    ONLINE FIRST

    This is an Online First, unedited version of this article. The final, edited

    version will appear in a numbered issue of CHEST  and may contain

    substantive changes. We encourage readers to check back for the final

    article. Online First papers are indexed in PubMed and by searchengines, but the information, including the final title and author list,

    may be updated on final publication. 

    http://journal.publications.chestnet.org/

    Online First articles are not copyedited prior to posting.

    ©American College of Chest Physicians.Reproduction of this article is prohibited without written permission from the

    American College of Chest Physicians. See online for more details.

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    P E. B MD PD1,2, F D3, D G, MD, MBA, FCCP4 

     

    (1)  D P C P, D P, M,

    P C C, , C.

    (2)  M C, M, P C C, ,

    C.

    (3)  M, P C C.

    (4)  P M, D P, P M,

    B D, C, C, IL, A.

    P E. B

    A P, D P C P; C;

    M; P C C.

    L 85 5 , 8330074 C

    @.. 

       : 249,  : 2497.

     LEEPDIORDERED BREAHING IN ONGER ADL

     C H M (MINAL) 2 N H 20092010

    FONDEC 11130573 .

    .

     , , , , , , .

    Abbreviations list: BMI, ; OR, ; DB, ; D,

    ; 95% CI, 95% . 

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     Prevalence and potential risk contributors of sleep-disordered

     breathing (SDB) in adolescents and younger adults remain unclear. We hypothesized that

    SDB prevalence in younger Hispanic adults is higher than the limited evidence indicates. 

    Methods: Population-based study of Hispanic subjects surveyed as part of the Chilean

     National Health Survey database. For this study, only subjects aged 15-40 years were

    included. Sleep and demographic questionnaires were used to assess SDB prevalence and its

    risk factors. Anthropometric measurements were performed in each subject. Prevalence was

    calculated for each SDB-related symptom. A regression model was constructed to investigate

    demographic risk factors of SDB.

    : A 2,147 . M ( D) 27.2 7.2 ,

    =899 (42%) . H

    53.8% , 38.3% . , ,

      DB

    2.5%. R 7.61 1.67 ,

    8.27 2.11 .

    , (O

    95% ) (2 1.62.5;

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    (DB) 1.

    R 14% 49%

    DB 2,3. H, DB

    , 1. I

    , DB

    2.

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    ,

    ,

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    40 ,

    DB

    , H,

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    .

    I, (.., HCH/OL ), R

    . DB 25.8% H 11,

    11,12. B >5 (), >15 (),

    >30/ () OA 33%, 14%, 6% 11.

    18%, 6%, 1.8%, 11. I ,

    1.3% HCH/OL

    11. ,

    DB H C. ,

    C N H

    DB DB .

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    C N H

    M H 20092010. I ,

    , , , .

    C >15

    .

    ,

    . R

    15 .

    85% , 12%.

    5,043

    . O C , 4.6%

    .

    F , 1540 . M

    C H M 13.

    . (BMI)

    : / ( * ). A

    BMI, : (BMI 25 30 /2), (BMI>30

    35 /2), (BMI > 35 /2). I ,

    ( ) .

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    . E , ,

    12 /

    /, . A .

    IRB P C C

    ( #:14432).

    A 13 C N H

    , .

    , ,

    . P .

    DB .

    4 LA

    PLAINO 14. I ,

    , .

    D (, D ,

    , , )

    . F

    , . P ,

    , . M

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    . A

    , , , DB

    . A, , BMI, ,

    .

    (OR) 95% (95% CI). A < 0.05

    . A P

    20.0 MAC.

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    O 5,043 C N H (20092010), 2,147

    1540 , . M ( D)

    27.2 7.2 , 899 (42%) . O

    =698 (35.7%), =387(19.8%) . 1

    .

    , , .

    2

    . DB 2.5%

    . 0.8% 3.8%, 15 40

    , . M D 7.61 1.67 ,

    8.27 2.11 . F 1 .

    .

    .

    ( 25. F 23

    . DB

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    ,

    > 35 (=0.048).

    I , BMI

    . 1519 , 2024

    >25 (OR= 0.53; 95% CI: 0.38

    0.72;

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    DB H C.

    DB ,

    .

    DB, DB BMI,

    , .

    DB

    1.

    I ,

    1517, DB

    . DB

    C, 18%

    ,

    . N ,

    DB

    .

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    , 18.

    DB

    ,

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    . I,

    DB

    ,

    . A DB

    3,19,20. . 2 3

    DB >65 21. I

    B ., 50 18.

    H, ,

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    DB (.., 12%

    ).

    M DB

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    C, R .

    H 11. , L

    , 14,400 11. R .

    HCH/OL ,

    , DB 25.8, 9.8, 3.9%, .

    39.9% , 31.1% 11.

    OA . >5

    (), >15 (), >30/ () OA 33%, 14%,

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    6% 11, 18%, 6%, 1.8% 3

    OA 11. DB :

    3.7% 1.6% . P

    OA. R

    . 11 

    . I ,

    : 27.2 , 45.9 HCH/OL ,

    OA, 2

    OA . HCH/OL

    M, P R, A

    11. I ,

    HCH/OL 11: 53.8% 38.3% 60%

    75%, . I , (.., 13.1%

    , 20.7% ) HCH/OL (..,

    18.5% 18.2, )11.

    H/L . G

    L A,

    .22 A , C

    L 44.7%

    , 52.45% E, 3% A

    .23 

    DB,

    24,

    .

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    . I, 2 ,

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    25,28, 29,

    30, 27 

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    35 ,

    >50 1.

    DB

    , DB

    27,31.

    DB

    3235. I ,

    DB . A

    ,

    DB. O

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    DB 36. I ,

    .

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    DB

    , ,

    DB.

    ACKNOLEDGEMEN

    PEB

    . PEB, FD DG

    , , .

    C H M (MINAL) D P H,

    N H 20092010

    . FONDEC

    11130573 .

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    FIGRE LEGEND

    F 1. M . F A

    , F B . E

    .

    F 2. P DB , (

    , ). P A ;

    P B ; P C +

    + .

    F 3. A. P , F B.

    ( , ).

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    REFERENCE

    1. Young T, Peppard PE, Gottlieb DJ. Epidemiology of obstructive sleep apnea: a population health

     perspective. Am J Respir Crit Care Med. 2002;165(9):1217-1239.

    2. Kapur VK. Obstructive sleep apnea: diagnosis, epidemiology, and economics. Respir Care.2010;55(9):1155-1167.

    3. Peppard PE, Young T, Barnet JH, Palta M, Hagen EW, Hla KM. Increased prevalence of sleep-

    disordered breathing in adults. Am J Epidemiol. 2013;177(9):1006-1014.

    4. Punjabi NM. The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc. 2008;5(2):136-

    143.

    5. Jordan AS, McEvoy RD. Gender differences in sleep apnea: epidemiology, clinical presentation and

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    2004;291(16):2013-2016.8. Shahar E, Redline S, Young T, et al. Hormone replacement therapy and sleep-disordered breathing. Am

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     breathing in a community-based sample. Am J Respir Crit Care Med. 1994;149(3 Pt 1):722-726.

    27. Ye L, Pien GW, Weaver TE. Gender differences in the clinical manifestation of obstructive sleep

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    TABLES

    Table 1. Demographic characteristics of the sample (n=2,146)

    Variable Men Women Total

    Gender 899(42) 1248(58) 2146

    Age (years)

    15-19 193 (21.5) 210(16.8) 403(18.8)

    20-24 171(19) 229(18.3) 400(18.6)

    25-29 141(15.7) 245(19.6) 386(17.9)

    30-34 172(19.1) 248(19.9) 420(19.5)

    35-40 222(24.7) 316(25.3) 538(25.1)

    Body mass index* 26.3 ± 4.5 26.7 ± 5.6 26.3 ± 5.2

    Waist circumference*(cm) 91.4 ± 41.5 85.7 ± 27.1 86.9 ± 12.9

    Neck circumference*(cm) 40.1 ± 34.3 35.8 ± 38.2 36 ± 5.9

    Nutritional status

     Normal (≥18.5 and

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    Table 2. A. Prevalence of sleep-disordered breathing symptoms and sleep duration for men

    stratified by age

    Variables Total 15-19 20-24 25-29 30-34 35-40

    Snoring 470 (53.8) 65 (35.3) 75 (45.2) 78 (56.5) 108(63.9) 144 (66.4)

    Witnessed apnea 136 (15.8) 10 (5.3) 12 (7.4) 28 (20.6) 38(23.2) 48 (22.9)

    Daytime somnolence 118 (13.1) 19 (9.8) 29 (17) 21 (14.9) 20(11.6) 29 (13.1)

    Restless sleep 257 (28.6) 35 (18.1) 57 (33.3) 46 (32.6) 50(29.1) 69 (31.1)

    Snoring+/apnea+/daytime

    somnolence+31 (3.7) 1 (0.5) 4 (2.5) 6 (4.5) 8(4.9) 12 (5.9)

    Sleep hours/weekday * 7.42 (1.57) 8.13 (1.78) 7.72 (1.52) 7.28 (1.64) 7.07(1.30) 6.93 (1.28)

    Sleep Hours/weekend * 8.16 (2.13) 8.79 (2.41) 8.19 (2.21) 8.11 (2.27) 7.97(1.97) 7.77 (1.68)

    All results are n (%). except for * mean (standard deviation).

    Table 2. B. Prevalence of sleep-disordered breathing symptoms and sleep duration for women

    stratified by age 

    Variables Total 15-19 20-24 25-29 30-34 35-40

    Snoring 464 (38.3) 63 (30.6) 66 (29.9) 92 (38.5) 98(40.5) 145 (47.5)

    Witnessed apnea 91 (7.6) 15 (7.4) 12 (5.3) 21 (8.8) 23(9.6) 20 (6.8)

    Daytime somnolence 258 (20.7) 45 (21.4) 47 (20.5) 53 (21.6) 57(23) 56 (17.7)

    Restless sleep 504 (40.4) 61 (29) 86 (37.6) 108 (44.1) 117(47.2) 132 (41.8)

    Snoring+/apnea+/daytimesomnolence+

    19 (1.6) 2 (1.0) 1 (0.5) 3 (1.3) 6(2.6) 7 (2.4)

    Sleep hours/weekday * 7.74 (1.72) 8.47 (1.82) 8.03 (1.78) 7.71 (1.68) 7.50(1.51) 7.27 (1.58)

    Sleep Hours/weekend * 8.35 (2.10) 8.91 (2.21) 8.5 8(2.23) 8.36 (2.06) 8.07(1.86) 8.01 (2.05)

    All results are n (%). except for * mean (standard deviation).

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    Table 3. Unadjusted and adjusted risk factors for snoring 

    OR IC 95% p-value OR* IC 95% p-value

    Males 1.9 1.57-2.28

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    Table 4. Unadjusted and adjusted risk factors for witnessed apnea

    OR IC 95% p-value OR* IC 95% p-value

    Males 2.4 1.79-3.21

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    Table 6. Unadjusted and adjusted risk factors for snoring+ witnessed apnea + daytime

    somnolence

    OR IC 95% p-value OR* IC 95% p-value

    Males 2.09 1.15-3.79 0.015 2.5 1.21-5.12 0.012

    Age group

    15-19 0.23 0.06-0.79 0.020 0.26 0.07-0.92 0.037

    20-24 0.31 0.10-0.94 0.039 0.37 0.12-1.14 0.084

    25-29 0.71 0.31-1.61 0.415 0.78 0.34-1.80 0.574

    30-34 0.93 0.45-1.95 0.865 0.94 0.45-1.97 0.873

    35-40 1 ref ref 1 ref ref

    BMI 1.06 1.01-1.11 0.005 1.06 0.99-1.13 0.061

    Educational level

    Low 1.98 0.67-5.83 0.211 1.82 0.61-5.50 0.281

    Medium 1.15 0.57-2.32 0.681 1.25 0.61-02.55 0.531

    High 1 ref ref 1 ref ref

    Neck circumference 1.00 0.99-1.00 0.975 0.98 0.92-1.06 0.734

    Waist circumference 1.00 0.99-1.00 0.374 0.99 0.98-1.01 0.793

    *OR were adjusted by age, gender, educational level, BMI, neck, and waist circumference.

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    254x190mm (72 x 72 DPI)

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    254x190mm (72 x 72 DPI)

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    254x190mm (72 x 72 DPI)

    Page 28