131 docs/… · web viewcardiac muscle physiology i. cardiac muscle cells: stable rmp, not...
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Cardiac Muscle Physiology
I. Cardiac MUSCLE cells: Stable RMP, not self-excitable. Cardiac muscle cells operate ONLY via twitches – they can never reach tetany, unlike skeletal muscle.
RECALL: Skeletal muscle – timing of twitch:
Cardiac muscle – timing of twitch:
Heartbeats are just one twitch after another. How to make contractions stronger? Increase calcium levels – cardiac muscle contractions are graded (similar to smooth muscle), and when there’s more calcium available, the contraction is stronger.
Skeletal: at optimal length, at tetany; variation in contraction = recruitment of motor units
Cardiac: entire muscle contracts (no motor units), cannot reach tetany variation in contraction = 1) increased stretch towards optimal length
2) graded contractions (the more Ca2+i, the stronger the contraction)
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2. Cardiac PACEMAKER cells: unstable membrane potentials that continually drift towards threshold (no RMP); because of this, they are “self-excitable”:
Neurotransmitters from the ANS simply affect the RATE of depolarization: