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BRAF,

BRAF α β

β

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BRAF

BRAF

BRAF

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in

vitro in vivo.

BRAF

BRAF

in vitro

in vivo

in vivo

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in vitro in vivo

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BRAF NRAS BRAF BRAF/NRAS

PTEN

PTEN

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γ PTEN

PTEN

PTEN

CTNNB1 β

PTEN

PTEN β

β

χ

β

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in vitro

in vivo

in vivo

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TNFRSF10C PDGFRB, TILR3,

MASP2 CLU

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ATG16L

ATG16L

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MAP1LC3B

MAP1LC3B

MAP1LC3B

MAP1LC3B MAP1LC3B

MAP1LC3B

MAP1LC3B

β

β

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β

In vitro β

β

β

β

β

β

β

β

BRAF

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in vivo β

β

β

β β

β

β

in vivo

BRAF

β

β

β

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β

BRAF,

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BRAF

BRAF

BRAF-

BRAF/NRAS-

PTEN

PTEN

β

β

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in vivo

in vitro, in vivo

γ

in vivo

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in vitro

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in vitro

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β

in vitro in vivo

in vitro in vivo

β

β

β

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BRAF

in vitro in vivo

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in vivo

in vivo

μ

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in vivo

in vivo

P .

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≤

PTEN PTEN

PTEN

PTEN

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γ

PTEN

PTEN

β

PTEN

β CTNNB1

β APC, APC2, AXIN1,

AXIN2 PTEN PTEN

PTEN

in vivo

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P .

BRAF-

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MAP1LC3B.

μ

P P

P

β

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μ

P

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Published OnlineFirst December 8, 2015.Cancer Discov   Weiyi Peng, Jie Qing Chen, Chengwen Liu, et al.   immunotherapyLoss of PTEN promotes resistance to T cell-mediated

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