1918 v. 1957 influenza

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    1918 vs. 1957 : Spanish vs. AsianPreparedness and Vaccinations

    Spread of Spanish Influenza 1918

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    Spanish Influenza vs. Asian Influenza

    In 1918, influenza is not a nationally

    reportable disease (CDC).

    February 1957 - the Asian influenza

    emerged in China.

    Scientific advancements make it easier to

    identify than the 1918 influenza.

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    Doctors in 1918Ignorance is Not Bliss

    Warned Public Health Officialsof Dire Consequences

    Urged Cities to PracticeIsolation and Quarantine

    Patriotic War FervorA Nave Population Stubborn City Leaders

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    Doctors and Hospitals in

    1957

    Influenza incidence

    reaches high levels Physicians offices

    crowded to overflowing Most patientsNot severely illDidnt need specialtreatment

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    1918-Public

    Health and Medi

    cal Eff

    orts

    Hospitals 1918

    Overflowed with

    patients

    Expanded treatment

    centers

    Intensified shortage ofmedical personnel

    Overwork and

    overexposure

    Just not enough

    Public Health Service - 1918

    Struggles withorganization/lack of

    leadership

    Unprepared

    Public Health Agencies

    Theoretical Jobs Now a

    Reality

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    1957 Public

    Health and Medi

    cal Eff

    orts

    The CDC ASTHO

    Intensively studied the

    epidemic

    Tried to predict

    diseases course for

    autumn

    Looming pandemic

    subject of special

    meeting at the

    Association of State and

    Territorial Health

    (ASTHO) Health officials met to

    discuss strategy

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    1918-1919 United States Public

    Health Service Measures

    A D i r e c t o r i n Ea c h S t a t e ! B o s t o n Wa n t s To o M a n y

    N u r s e S h o r t a g e

    N u r s e s N e c e s s a r y

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    1957 US Public

    Health Measu

    res

    June 1957 only weekly

    telegraph reports from CDC

    Influenza Surveillance Unit

    National Health Survey

    County Reports

    Improvements ASTHO Recommendations

    Home care

    Safety Measures

    Not many restrictions

    Quarantine not considered

    effective

    no practical advantage

    in the closing of schools

    or the curtailment of

    public gatherings as it

    relates to the spread of

    this disease.

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    US Government Preparedness

    1918

    No problem finding the $$ 2 Hours for Congress to approve a

    budget The problem?

    No funds appropriated byCongress for prevention

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    US Government Preparedness

    1957

    Armed Forces Epidemiological Board 1940 Commission on Influenza Studies of epidemiology and prevention

    International Influenza Study

    Program of the WHO 1948

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    (Lackof) Treatment - 1918 No influenza vaccine

    "Physicians triedeverything they

    knew.

    Only one therapeutic

    measure shows

    positive results

    1931 Viral Growth

    1940s First approvedinactivated vaccines for

    influenza

    Over time advances in

    fields of immunologyand vaccinology enable

    mass production

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    (Presence of) Treatment 1957 To prevent illness and

    death from epidemic

    influenza within the limits ofavailable vaccine.

    There was a shortage of

    vaccine in August

    Surgeon General Leroy

    Burney makes an

    announcement

    Vaccine allocatedaccording to statespopulation

    Distribution bymanufacturers throughcommercial networks

    Recommended priority

    be given to public healthworkers and communityservice providers, as wellas those with specialcircumstances.

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    In his book,AmericasForgotten Pandemic, Alfred W.Crosby wrote, (the UnitedStates) "was not merelyunprepared to control thespread of influenza. It had

    carefully, if unintentionally,prepared itself to expedite thecultivation and disseminationof the influenza virus of 1918."

    Do You Agree? Why?

    What would you change?

    Were They

    Ready???

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    Ti

    m

    el

    i

    n

    e

    o

    f

    V

    a

    c

    c

    i

    ne

    P

    r

    o

    d

    u

    c

    ti

    o

    Ma

    y

    19

    5

    7

    No

    v

    19

    5

    7

    June July Aug. Sept. Oct.

    May 13 USreceives first

    influenzaspecimens fromHong Kong

    May 22 Definitiveidentification of new

    influenza strain

    Vaccine trialsconducted

    4 Million DosesReleased

    9 Million DosesReleased

    16 MillionDoses Released

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    So

    What

    sthe P

    roblem?

    Only enough vaccine for 17% of Population

    Vaccine only 60% effective

    Epidemic peaked in late October, but rates sharply

    declined in November

    Have supply, but demand is gone

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    Refe

    ren

    ces

    Taubenberger JK, Morens DM. 1918 influenza: the mother of all pandemics. Emerg Infect

    Dis [serial on the Internet]. 2006 Jan [date cited]. Available from

    http://www.cdc.gov/ncidod/EID/vol12no01/05-0979.htm

    D. A. Henderson, Brooke Courtney, Thomas V. Inglesby, Eric Toner, and Jennifer B. Nuzzo.Public health and medical responses to the 1957-58 influenza pandemic. Biosecurity and

    Bioterrorism. Volume 7, Number 3, 2009. Mary Ann Liebert, Inc.

    http://www.upmc-biosecurity.org/website/resources/publications/

    2009/2009-08-05-public_health_medical_responses_1957.html

    http://www.pandemicflu.gov/storybook/index.html

    http://www.jhsph.edu/publichealthnews/articles/2005/great_influenza.html

    Crosby, Alfred W. Jr., Epidemic and Peace 1918, Greenwood Press 1976. Updated

    introduction and reprinted as, Americas Forgotten Pandemic, Cambridge Press 1989