2006 catholic university presentation
DESCRIPTION
Working with bioinformatics research teamsTRANSCRIPT
Explorations in bioinformatics
Division of Computational Biosciences
Douglas James Joubert, MLISBiomedical InformationistNational Institutes of Health Library
May 10, 2006
EXPLORATIONS IN BIOINFORMATICS
EXPLORATIONS IN BIOINFORMATICS
Bioinformatics is multi-faceted
EXPLORATIONS IN BIOINFORMATICS
Bioinformatics – My Approach
EXPLORATIONS IN BIOINFORMATICS
Bioinformatics – My Approach
Formal and informal educational opportunities
MS in bioinformatics NIH SIGs
ACM & IEEE SIGs AMIA Working Groups
EXPLORATIONS IN BIOINFORMATICS
Bioinformatics – My Approach
Formal and informal educational opportunities
MS in bioinformatics NIH SIGs
…Talk the talk
EXPLORATIONS IN BIOINFORMATICS
What is “Familiar” About MSCL – Informationist Collaboration
Primary role is data and text mining Evaluate resources - resources typically text
mining tools and database interfaces Conduct searches, subject terms are gene sets
and microarray probe IDs; methods of database access are unique
EXPLORATIONS IN BIOINFORMATICS
What is Unique About MSCL – Informationist Collaboration
MSCL does not use “library resources” in the traditional sense of the word
50% work commitment in lab Office space @ DCB, access to the NIH
mainframe through HELIX MSCL collaborative efforts are intermittent, and
project bound MSCL has been working with some core groups
for 5+ years
Primary Roles with MSL
SequenceAnalysis
Intermolecular &Biological Pathways
Data andText Mining
Genes &Proteins
SequenceAnalysis
Intermolecular &Biological Pathways
Data andText Mining
Genes &Proteins
Roles linked to a clear vision
MSCL DLS
EXPLORATIONS IN BIOINFORMATICS
What Tools do I use?
Use bioinformatics tools to explore modeled relationships between proteins, genes, complexes, cells, tissues, drugs, and diseases
Focus on information about gene function, metabolic, signaling, and canonical pathways
Sequence Analysis
subject terms
Sequence Analysis
EXPLORATIONS IN BIOINFORMATICS
Phylogenetic Analysis
Origins of a genetic disease
At sequence level looking for unique and non-unique characters
S. Wain-Hobson. (1998). 1959 and all that Nature 391: 531-532.
EXPLORATIONS IN BIOINFORMATICS
Protein Structure Analysis and Protein-Protein Interactions
Field of structural biology Moving from Sequence to
3-D modeling Good tutorial available at:
http://www.usm.maine.edu/~rhodes/SPVTut/
EXPLORATIONS IN BIOINFORMATICS
Pathway Analysis
EXPLORATIONS IN BIOINFORMATICS
Contact Information
Douglas J. Joubert, MLISBiomedical InformationistNational Institutes of Health LibraryBldg. 10, Room 1L09ABethesda, MD 20906-1150Phone: 301.594.6282E-mail: [email protected]: [email protected]