Evidence of the Recombinant Origin of a Bat SARS-Like Coronavirus and Its Implications on

the Direct Ancestor of SARS Coronavirus

Dr. Chung-Chau Hon School of Biological Sciences, The University of Hong Kong

Hong Kong SAR, China

Amplifying Host and Natural Reservoir

Currently sampled Bt-SLCoVs are too distant to be the director ancestor.

HB-SLCoV is closely related to Hu-SCoV; Contains direct ancestor?

tMRCA-Hu (estimated from S1 dataset) as a prior for tDIV-Hu/HB Bayesian dating in ORF1 dataset

S1-derived tMRCA-Hu prior improved the precision of tDIV-Hu/HB posterior of the ORF1 data set

!"#$%%&'()*+(,-!.*-!.%