2017 asco recap: the latest in colorectal cancer research #crcwebinar
TRANSCRIPT
2017 ASCO RECAP: The Latest in
Colorectal Cancer Research
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• Speaker: Dustin Deming, MD
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Speaker:
Dustin Deming, MD, is a gastrointestinal
oncologist and colorectal cancer laboratory
researcher at the University of Wisconsin Carbone
Cancer Center.
He has a subspecialty focus in the treatment of
colon, rectal and anal cancers. At the age of 31, he
was diagnosed with stage III rectal cancer, the very
disease he has dedicated to treating and advancing
therapies for.
As both a practitioner, researcher AND a patient, he
knows first-hand what the cancer journey is like; he
aims his research to fundamentally change the way
in which we treat gastrointestinal cancers to amore
personalized approach.
ASCO Update 2017:Colorectal Cancer
Dustin Deming, MD
McArdle Laboratory for Cancer Research
Carbone Cancer Center
University of Wisconsin
6/23/2017
Outline
• Metastatic Cancer: Advances in Immunotherapy
• Metastatic Cancer: Advances in Precision Medicine
• Adjuvant Chemotherapy: 3 vs 6 months
• Survivorship Care
Metastatic Cancer: Advances in Immunotherapy
• Nivolumab and Ipilimumab for MSI-H CRC
• CEA-TCB Bispecific Antibody
• Versican Proteolysis as a New Immune Biomarker
Combination of nivolumab (nivo) + ipilimumab (ipi) in the treatment of patients (pts) with deficient DNA mismatch repair (dMMR)/high microsatellite instability (MSI-H) metastatic colorectal cancer (mCRC): CheckMate 142 study.
Presented by: Thierry Andre, MD
Nivolumab and Ipilimumab for MMR deficient cancers
Nivolumab and Ipilimumab for MMR deficient cancers
Nivolumab and Ipilimumab for MMR deficient cancers
Nivolumab and Ipilimumab for MMR deficient cancers
CEA-TCB Antibody
Safety profile of CEA-TCB was manageable as monotherapy and <br />in combination with atezolizumab
Presented By Josep Tabernero at 2017 ASCO Annual Meeting
CEA-TCB at doses of ≥ 60 mga demonstrated clinical activity in mCRC as monotherapy and in combination with atezolizumab
Presented By Josep Tabernero at 2017 ASCO Annual Meeting
CEA-TCB at doses ≥ 60 mg + atezolizumab demonstrated enhanced clinical activity vs monotherapy in mCRC
Presented By Josep Tabernero at 2017 ASCO Annual Meeting
CEA-TCB at doses ≥ 60 mg + atezolizumab demonstrated promising clinical activity in 3L+ patients with MSS mCRC
Presented By Josep Tabernero at 2017 ASCO Annual Meeting
Versican Proteolysis
• A new biomarker for immune infiltration in colorectal cancers
Interaction Between Cancer Genomics and the Tumor Microenvironment
Dr. Fotis Asimakopoulos
VCAN Proteolysis Correlates with CD8+ T-Cell Infiltration
Metastatic Cancer: Advances in Precision Medicine• Cetuximab, Vemurafenib and Irinotecan for BRAF
mutant cancers
Randomized trial of irinotecan and cetuximab with or without vemurafenib in BRAF-mutant metastatic colorectal cancer (SWOG S1406)
Presented By Scott Kopetz at 2017 ASCO Annual Meeting
Introduction
Presented By Scott Kopetz at 2017 ASCO Annual Meeting
Study Design
Presented By Scott Kopetz at 2017 ASCO Annual Meeting
Grade 3/4 Adverse Events
Presented By Scott Kopetz at 2017 ASCO Annual Meeting
Primary Endpoint: Progression-free survival
Presented By Scott Kopetz at 2017 ASCO Annual Meeting
Response Rate
Presented By Scott Kopetz at 2017 ASCO Annual Meeting
Subgroup Analyses
Presented By Scott Kopetz at 2017 ASCO Annual Meeting
Secondary Endpoint: Overall Survival
Presented By Scott Kopetz at 2017 ASCO Annual Meeting
Adjuvant Chemotherapy for Stage III Colon Cancer:
3 vs 6 months duration
Prospective Pooled Analysis of Six Phase III Trials Investigating Duration of Adjuvant Oxaliplatin-based therapy (3 vs. 6 months) for Patients with Stage III Colon Cancer: <br />The IDEA (International Duration Evaluation of Adjuvant Chemotherapy) Collaboration
Presented By Qian Shi at 2017 ASCO Annual Meeting
Study Schema
Presented By Qian Shi at 2017 ASCO Annual Meeting
IDEA Trials Summary
Presented By Qian Shi at 2017 ASCO Annual Meeting
Adverse Events
Presented By Qian Shi at 2017 ASCO Annual Meeting
Primary DFS Analysis (mITT)
Presented By Qian Shi at 2017 ASCO Annual Meeting
Primary DFS Analysis (mITT), cont.
Presented By Qian Shi at 2017 ASCO Annual Meeting
DFS Comparison by Risk Group and Regimen, cont.
Presented By Qian Shi at 2017 ASCO Annual Meeting
Recommendations Going Forward
Ways Oncologists are Thinking About this Data
• 6 months of adjuvant chemotherapy for everyone
• 3 months for low risk and 6 months for high risk
• Give oxaliplatin for first 3 months only, and finish with infusional 5FU for total of 6 months
• Maybe CAPEOX is better than FOLFOX
Dusty’s Opinion
• Risk/benefit ratio approach
Survivorship Care
• Tree Nuts
• Vitamin D
• PET/CT scans
Nut Consumption and Survival in Stage III Colon Cancer Patients: Results from CALGB 89803 (Alliance)
CALGB 89803
Slide 13
Results
Some preclinical rationale
Analysis of serum vitamin D levels and prognosis in stage III colon carcinoma patients treated with adjuvant FOLFOX+/- cetuximab chemotherapy: NCCTG N0147 (Alliance)
Vitamin D by Tertile with Outcome
Secondary analyses of 89803
What do I do or at least try to do?
• Aspirin – 81-325mg per day
• Exercise – Half hour of moderate exercise more days than not
• Multi-vitamin
• Low glycemic index diet
• Coffee
• Tree nuts or tree nut products
Question & Answer:
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