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Page 1: 3 Olympic Ophthalmics OIS ASCRS FINALGlobal Neurostimulation devices MarketSize and Forecast, 2015 - 2024 (US$ Billion) 2016 2017 2024 2018 Source: 2019 2021 Variant Market Research

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Michael Gertner MDFounder and CEO

5-02-19

Page 2: 3 Olympic Ophthalmics OIS ASCRS FINALGlobal Neurostimulation devices MarketSize and Forecast, 2015 - 2024 (US$ Billion) 2016 2017 2024 2018 Source: 2019 2021 Variant Market Research
Page 3: 3 Olympic Ophthalmics OIS ASCRS FINALGlobal Neurostimulation devices MarketSize and Forecast, 2015 - 2024 (US$ Billion) 2016 2017 2024 2018 Source: 2019 2021 Variant Market Research

Dieckman et. al. Ocular Surface 17 (2019)

Page 4: 3 Olympic Ophthalmics OIS ASCRS FINALGlobal Neurostimulation devices MarketSize and Forecast, 2015 - 2024 (US$ Billion) 2016 2017 2024 2018 Source: 2019 2021 Variant Market Research

iTEAR** -- A Novel Neurostimulation Approach With Sonic Energy

** Investigational Device, Not FDA Cleared

Page 5: 3 Olympic Ophthalmics OIS ASCRS FINALGlobal Neurostimulation devices MarketSize and Forecast, 2015 - 2024 (US$ Billion) 2016 2017 2024 2018 Source: 2019 2021 Variant Market Research
Page 6: 3 Olympic Ophthalmics OIS ASCRS FINALGlobal Neurostimulation devices MarketSize and Forecast, 2015 - 2024 (US$ Billion) 2016 2017 2024 2018 Source: 2019 2021 Variant Market Research
Page 7: 3 Olympic Ophthalmics OIS ASCRS FINALGlobal Neurostimulation devices MarketSize and Forecast, 2015 - 2024 (US$ Billion) 2016 2017 2024 2018 Source: 2019 2021 Variant Market Research
Page 8: 3 Olympic Ophthalmics OIS ASCRS FINALGlobal Neurostimulation devices MarketSize and Forecast, 2015 - 2024 (US$ Billion) 2016 2017 2024 2018 Source: 2019 2021 Variant Market Research

Schirmer Meibomian Gland Score

TBUT

Day 0 5.7 13.2 5.4

Day 30 7.7 20.1 7.8

P value <.01 <.01 <.01

Page 9: 3 Olympic Ophthalmics OIS ASCRS FINALGlobal Neurostimulation devices MarketSize and Forecast, 2015 - 2024 (US$ Billion) 2016 2017 2024 2018 Source: 2019 2021 Variant Market Research

5/2/19

Page 10: 3 Olympic Ophthalmics OIS ASCRS FINALGlobal Neurostimulation devices MarketSize and Forecast, 2015 - 2024 (US$ Billion) 2016 2017 2024 2018 Source: 2019 2021 Variant Market Research
Page 11: 3 Olympic Ophthalmics OIS ASCRS FINALGlobal Neurostimulation devices MarketSize and Forecast, 2015 - 2024 (US$ Billion) 2016 2017 2024 2018 Source: 2019 2021 Variant Market Research

Meibum Secretion

30s 4x speed

Page 12: 3 Olympic Ophthalmics OIS ASCRS FINALGlobal Neurostimulation devices MarketSize and Forecast, 2015 - 2024 (US$ Billion) 2016 2017 2024 2018 Source: 2019 2021 Variant Market Research
Page 13: 3 Olympic Ophthalmics OIS ASCRS FINALGlobal Neurostimulation devices MarketSize and Forecast, 2015 - 2024 (US$ Billion) 2016 2017 2024 2018 Source: 2019 2021 Variant Market Research

5/2/19

Adverse Events

Page 14: 3 Olympic Ophthalmics OIS ASCRS FINALGlobal Neurostimulation devices MarketSize and Forecast, 2015 - 2024 (US$ Billion) 2016 2017 2024 2018 Source: 2019 2021 Variant Market Research