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8/2/2019 5-Lipoxygenase is a key determinant of acute myocardial inflammation and mortality during Trypanosoma cruzi inf

1/11

Dsi`infj fsuiajh

8,Jiwd}y`hnfqh iq f ohy ehuhslinfnu db faxuh lydafseifj inffifllfuidnfne ldsufjiuy exsin` Usywfndqdlf asx{i inbhauidn

Pfnehs S. Wfrfnhjji f*6* Bshey S.Q. @xuihssh{ f*6* Bjfrif Q. Lfsifnd f* Aichjh L. Wsfed c*Chfusi{ Sdqqhuui Bhsshisf f* Lfxsd Lfsuinq Uhi}hisf a* Ajfxeid Afnhuui e* Lfsadq F. Sdqqi c*

Bhsnfned V. Axnmf h* Kdfd Q. Qijrf f*+

fEhwfsulhnu db Cidamhliqusy fne Illxndjd`y* Sichisfd Wshud Qamddj db Lheiainh* Xnirhsqiuy d b Qf d Wfxjd* Fr. Cfnehisfnuhq* 1977 , 6575 9,977 Sichisf d Wshud*

QW* Csf{ijc Ehwfsulhnu db Wfumdjd`y* Sichisfd Wshud Qamddj db Lheiainh* Xnirhsqiuy db Qf d Wfxjd* Csf{ij

aEhwfsulhnu db Cidamhliqusy fne Illxndjd`y* IAC* Bhehsfj Xnirhsqiuy db Linfq @hsfiq* Chjd Mdsi{dnuh* L@* Csf{ije

Afsjdq Amf`fq Bijmd Inquiuxuh db Cidwmyqiaq* Bhehsfj Xnirhsqiuy db Sid eh Kfnhisd* Csf{ijh Ehwfsulhnu db Wmfslfadjd`y* Sichisfd Wshud Qamddj db Lheiainh* Xnirhsqiuy db Qf d Wfxjd* Csf{ij

Shahirhe 3= Ndrhlchs 3779? faahwuhe 17 Lfsam 3767

Frfijfcjh dnjinh = Fwsij 3767

Fcqusfau

Umiq quxey wsdriehq hriehnah qxwwdsuin` umh iehf umfu fjumdx`m inffifllfudsy ahjjq li`sfuidn ud umh afseifa uiqqxh iq nhahqqfsy ud adnusdj umh

`sdpum db Usywfndqdlf asx{i* umh h}ahqqirh inffix} db qxam ahjjq exsin` faxuh lydafseiuiq lfy ch ehjhuhsidxq ud umh mdqu. Wsdexauidn db jiwie

lheifudsq db inffifllfuidn jioh jhxodusihnhq -JUq) fjdn` pium ayudoinhq fne amhldoinhq jfs`hjy inffixhnahq umh qhrhsiuy db inffifllfudsy inkxsy in

shqwdnqh ud uiqqxh wfsfqiuiql. U. asx{i inbhauidn in liah ehstaihnu in 8,jiwd}y`hnfqh -8,JD)* umh hn{ylh shqwdnqicjh bds umh qynumhqiq db JUq fne

dumhs jiwie inffifllfudsy lheifudsq* shqxjuhe in usfnqihnujy inashfqhe wfsfqiuhlif* fne ilwsdrhe qxsrirfj sfuh adlwfshe pium PU liah. Lyd,

afseif bsdl 8,JD$ liah h}miciuhe shexahe inffifllfuidn* adjjf`hn ehwdqiuidn* fne li`sfuidn db AE5* AE=* fne IBN,`,wsdexahs ahjjq

adlwfshe pium PU jiuuhslfuhq. Ldshdrhs* ehashfqhe fldxnuq db UNB,f* IBN,`* fne niusia d}ieh qynumfqh phsh bdxne in umh mhfsuq db 8,JD$

liah. Inuhshquin`jy* ehqwiuh db hfsjy mi`mhs wfsfqiuia jdfe* 8,JD$ liah qxsrirhe* fne adnusdjjhe U. asx{i inbhauidn. Umhqh shqxjuq qmdp umfu

hbstaihnu wfsfqiuh ajhfsfnah iq wdqqicjh in f adnuh}u db ldehsfuh inffifllfudsy shqwdnqh* fq daaxsshe in 8,JD$ liah* in pmiam shexahe

lydafseiuiq wsduhauq umh fnilfjq exsin` U. asx{i inbhauidn.

3767 Hjqhrihs Lfqqdn QFQ. Fjj si`muq shqhsrhe.

Ohypdseq; Usywfndqdlf asx{i? Lydafseiuiq? 8,Jiwd}y`hnfqh? Jhxodusihnhq? Inffifllfuidn

6. Inusdexauidn

Amf`fq mhfsu eiqhfqh -AME) iq fldn` umh ldqu qhrhsh

ajiniafj lfnibhqufuidnq db umh inbhauidn pium umh mhldffif`hjjfuh

wsdud{dfn Usywfndqdlf asx{i fne adnquiuxuhq f lfkds wsdcjhl

ud wxcjia mhfjum in Qdxum fne Ahnusfj Flhsiaf. Umiq qyquhlia

inbhauidn iq amfsfauhsi{he cy fn faxuh wmfqh pmhn aisaxjfuin`

wfsfqiuhq fne inadnqufnu inffifllfudsy shfauidn afn ch bdxne fu

umh qiuh db wfsfqiuh indaxjfuidn. Fjqd* inuhnqh inffifllfuidn afnxnehs`d fu umh lydafseixl exsin` umiq quf`h db eiqhfqh* exh ud

wfsfqiuh usdwiql ud afseidlydayuhq. Umhshfbuhs* umh lydafseifj

f``shqqidn iq xqxfjjy adnusdjjhe jhfein` ud umh inehuhslinfuh

wmfqh db umh eiqhfqh. Mdphrhs* fsdxne 17( db wfuihnuq hrhnux,

fjjy ehrhjdw amsdnia amf`fqia afseidlydwfumy -AAA)* pmiam

adnqiqu db qhrhsh* xnadnusdjjhe lydafseiuiq pium inuhnqh stcsdqiq

fne iq ajiniafjjy lfnibhquhe fq adlwjh} fssmyumlifq* rhnusiaxjfs

fnhxsiql* mhfsu bfijxsh* umsdlcdhlcdjiql* fne qxeehn ehfum*

lfinjy exh ud qusxauxsfj eiquxscfnahq fne inuhnqh stcsdqiq db

afseifa uiqqxh fq phjj fq liasdrfqaxjfs amfn`hq _6*3\.

+ Adsshqwdnein` fxumds. Uhj.; 88 62 1273 1353? bf}; 88 62 1211 2=57.

H,lfij feeshqq; kqeqijrfGblsw.xqw.cs -K.Q. Qijrf).6 Umhqh fxumdsq adnusicxuhe hvxfjjy ud umiq pdso fne qmdxje ch adnqiehshe fq

ad,stsqu.

63=2,5809$% , qhh bsdnu lfuuhs 3767 Hjqhrihs Lfqqdn QFQ. Fjj si`muq shqhsrhe.

edi;67.6762$k.liainb.3767.71.762

Liasdchq fne Inbhauidn 63 -3767) 8=0h890ppp.hjqhrihs.adl$jdafuh$liainb
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2/11

Fjumdx`m umh wshaiqh bfaudsq `drhsnin` eiqhfqh wsd`shqqidn

shlfin wddsjy xnehsqudde* umh afqafeh db inffifllfudsy hrhnuq

umfu daaxsq fu umh afseifa uiqqxh exsin` umh faxuh wmfqh db umh

inbhauidn ahsufinjy adnusicxuhq ud umh dnqhu fne qhrhsiuy db

AAA _1\. Inehhe* qdlh quxeihq qx``hqu umfu afseifa instjusfuin`

jhxodayuhq lfy adnusicxuh ud lydafseifj eyqbxnauidn exsin`

U. asx{i inbhauidn cy shjhfqin` ds inexain` umh shjhfqh dbmfslbxj fsfamiednia faie lhufcdjiuhq qxam fq JUq* pmiam jhfeq

ud fjuhshe afseifa wmyqidjd`y _5\. JUq adnquiuxuh f ajfqq db

wduhnu wsdinffifllfudsy lheifudsq umfu wfsuiaiwfuh eishaujy fne

ineishaujy in wfumdwmyqidjd`y db afseidrfqaxjfs eiqhfqhq _8*2\.

Umhis cidqynumhqiq ehsirhq bsdl umh d}iefuidn db fsfamiednia

faie cy 8,jiwd}y`hnfqh -8,JD) piumin `sfnxjdayuhq* lfasd,

wmf`hq fne lfqu ahjjq fu hfsjy quf`hq db inffifllfuidn.

Umh li`sfuidn db jhxodayuhq ud umh lydafseixl iq ajdqhjy

sh`xjfuhe cy umh wsdexauidn db amhldfuusfaufnuq fne h}wshq,

qidn db umhis shahwudsq in uiqqxh,inrfein` ahjjq _1*0\. In bfau* umh

amhldoinhq AAJ1* AAJ5* fne AAJ8 fsh wsdexahe cy

lfasdwmf`hq fne afseidlydayuhq qddn fbuhs umh inbhauidn* fne

ldexjfuh umh jhxodayuhq li sfuidn* wmf`dayudqiq fneehqusxauidn db wfsfqiuhq cy lfasdwmf`hq in f niusia d}ieh-ND),

ehwhnehnu lfnnhs _=*9\. Umh mhfsu,instjusfuin` inffifllfudsy

ahjjq wsdexah qhrhsfj ayudoinhq inajxein` INB,` fne UNB,f*

umfu fsh hqqhnuifj bds umh adnusdj db uiqqxh wfsfqiuiql _0\. Umhqh

efuf wdinuhe dxu fn ilwdsufnu sdjh bds afseifa uiqqxh inffifl,

lfuidn in mdqu wsduhauirh shqwdnqh _67*66\.

Umh inuhnqiuy db faxuh ahjjxjfs inffifllfuidn in shqwdnqh ud

U. asx{i iq fjqd ehwhnehnu dn f qhsihq db qi`nfjq usi``hshe cy

bfaudsq wsdexahe cy inkxshe uiqqxh. Qxam qi`nfjq adlwsiqh

fsfamiednia faie ehsirfuirhq* inajxein` JUC5 fne ayquhinyj JUq

-JUA5* JUE5 fne JUH5) _63h68\. 8,JD iq umh hn{ylh shqwdn,

qicjh bds qynumhqiq db JUq* fne iq wsilfsijy h}wshqqhe in `sfn,xjdayuhq* lfasdwmf`hq* ehnesiuia ahjjq fne lfqu ahjjq _62*60\.

JUC5 iq qynumhqi{he cy shqiehnu fne shasxiuhe jhxodayuhq exsin`

inbhauidnq pium cfauhsif* bxnì* risxqhq* fne wsdud{df _6=\* fne

fauirfuhq lfasdwmf`hq ud oijj umh inusfahjjxjfs bdslq db U. asx{i

_69\. In feeiuidn* JUC5 adnusdjq umh li`sfuidn fne hbbhauds

bxnauidnqdb jhxodayuhq in qiuhq db inffifllfuidn_37\. Binfjjy* JUq

fsh fjqd fcjh ud ldeiby umh wsdexauidn db ayudoinhq cy U ahjjq fne

ldndayuhq _36*33\. In faadsefnah*umh cjdaofeh db JUC5 shahwuds

in liah inbhauhe pium U. asx{i shqxjuq in inashfqhe wfsfqiuhlif*

qx``hquinùmfu iu lfy adnusicxuh ud mdqu wsduhauirh shqwdnqh _31\.

Umhshbdsh* ph inrhqui`fuh umh wfsuiaiwfuidn db 8,JD fne iuq

ehsirfuirh JUC5 in umh wfumd`hnhqiq db lydafseiuiq exsin`

faxuh wmfqh db h}whsilhnufj inbhauidn pium U. asx{i. Dxs shqxjuq

qmdp umfu ehqwiuh db inashfqhe whfo db wfsfqiuhlif* liah

ehstaihnu db 8,JD fsh fcjh ud fsshqu umh wfsfqiuh cxsehn fne

h}miciu inashfqhe shqiqufnah ud U. asx{i inbhauidn* qinah umhy

qmdp inashfqhe qxsrirfj fqqdaifuhe ud shexahe afseifa eflf`h

fne qafsah uiqqxh wfsfqiuiql.

3. Lhumdeq

3.6. Fnilfjq

Bhlfjh pije uywh -PU) fne 8,JD ehstaihnu -8,JD$) liah

db umh 639 qusfin* 2h

= phhoq dje* phsh lfinufinhe xnehs

qufnefse adneiuidnq in umh fnilfj mdxqhq fu dxs inquiuxuidnq.

Fjj wsdahexshq mfe wsids fwwsdrfj bsdl umh jdafj fnilfj humiaq

adlliuuhh.

3.3. Wfsfqiuhq fne h}whsilhnufj inbhauidn

Umh Y qusfin db U. asx{i pfq `sdpn in umh smhqxq ldnohyoienhy hwiumhjifj ahjjq -JJA,LO3 Jinh). PU fne 8,JD$

liah phsh inbhauhe cy fn inusfwhsiudnhfj -i.w.) inkhauidn db 677

cjdde usywdlfqui`duhq bsdl f qusfin,lfuamhe ldxqh. Umh

wfsfqiuhlif pfq hrfjxfuhe in fjuhsnfuhe efyq* qufsuin dn 8

efyq wdqu,inbhauidn -w.i.) in f qflwjh db 8 lJ db cjdde dcufinhe

bsdl umh ufij rhin. Qxsrirfj sfuhq phsh ehuhslinhe in ineh,

whnehnu `sdxwq db 37 fnilfjq xnuij 27 efyq w.i.

3.1. Miqudjdìafj fnfjyqiq

Fbuhs 67* 68 fne 37 efyq w.i. pium U. asx{i* mhfsuq phsh

shldrhe bsdl liah* st}he in nhxusfj cxbbhshe 67( bdslfjeh,

myeh in WCQ* fne 8,ll qjiahq wshwfshe fne qufinhe hiumhs piummhlfud}yjin fne hdqin-M"H) ds pium wiasdqisixq she. Inffifl,

lfuidn pfq qadshe cy adxnuin` umh udufj nxlchsq db inffifl,

lfudsy ahjjq in 57 liasdqadwh sthjeq -} 377) whs uiqqxh qhauidn

db strh liah bsdl hfam `sdxw fne umh vxfnuistafuidnq phsh

whsbdslhe in umshh ndnadnui`xdxq qhauidnq in f cjinehe

lfnnhs cy upd shqhfsamhsq fq wshridxqjy ehqasiche _35\. F

lhumde bds umh vxfnuiufuirh h}flinfuidn db umh mhfsu uiqqxh pfq

afssihe dxu in wiasdqisixq she qufinhe qjiehq fu lheixl wdphs

ji`mu liasdqadwia sthjeq -} 387); f 677,wdinu daxjfs inuh`sfuidn

hyhwihah II -Afsj [hiqq) pfq xqhe ud hquilfuh umh rdjxlh

bsfauidn -() db stcsdqiq in wiasdqisixq,she,qufinhe qhauidnq.

Uphnuy sthjeq db mhfsu uiqqxh phsh fnfjy{he bds hfam ldxqh* fqehqasiche _38\.

3.5. Lhfqxshlhnu db ayudoinhq fne JUC5

Adnahnusfuidnq db ayudoinhq in uiqqxh mdld`hnfuhq bsdl

mhfsu* jirhs* fne qwjhhnq phsh lhfqxshe cy HJIQF. Umh IBN,`

-DwUHIF* CE Cidqaihnah* Qfn Eih`d,AF)* UNB,f* IJ,5* fne

IJ,67 -Exdqhu S"E Qyquhlq* Linnhfwdjiq,LN)* phsh

fqqfyhe bdjjdpin` umh lfnxbfauxshs inqusxauidnq. Umh shfauidn

pfq shrhjhe pium whsd}iefqh,adnkx`fuhe qushwufriein -Rhauds

Jfcdsfudsihq* Cxsjin`flh,AF) bdjjdphe cy umh qxcqusfuh

adnufinin` ULC -Wsdlh`f* Lfeiqdn,PI) fq f amsdld hn.

Dwuiafj ehnqiuihq -D.E.) db qflwjhq phsh umhn shfe fu 587 nl

fne umh adnahnusfuidnq db ayudoinhq phsh afjaxjfuhe cy

h}usfwdjfuin` umh D.E. dcufinhe bsdl f qufnefse axsrh db hfam

shadlcinfnu ayudoinh.

Umh jhrhjq db JUC5 in mhfsu mdld`hnfuhq phsh ehuhslinhe

cy hn{ylh illxndfqqfy xqin` f adllhsaifj oiu -CidusfoUL*

Flhsqmfl Wmfslfaif Ciduham* XO) faadsein` ud umh lfnx,

bfauxshsq inqusxauidnq.

3.8. ND vxfnuistafuidn

Cjdde pfq dcufinhe bsdl umh shusd,dsciufj wjh}xq db liah fu

67* 68* fne 37 efyq w.i. Niusfuh pfq shexahe ud niusiuh pium niusfuh

8== P.S. Wfrfnhjji hu fj. $ Liasdchq fne Inbhauidn 63 -3767) 8=0h890
http://www.elsevier.com/locate/micinfhttp://www.elsevier.com/locate/micinfhttp://www.elsevier.com/locate/micinfhttp://www.elsevier.com/locate/micinfhttp://www.elsevier.com/locate/micinf


3/11

shexaufqh fne umh niusiuh adnahnusfuidn ehuhslinhe cy umh @sihqq

lhumde. In umiq fqqfy* 7.6 lJ db shexaufqh,ushfuhe qhsxl pfq

inaxcfuhe bds 67 lin pium 7.6 lj db @sihqq shf`hnu in f liasd,

wjfuh* fne umhn umh D.E. pfq shfe fu 887 nl _32\. Umh ND3adnahnusfuidn pfq afjaxjfuhe bsdl umh D.E. rfjxhq db f qufnefse

axsrh db NfND3-6h377 lldj$J) fq wshridxqjy ehqasiche _30\.

3.2. Illxndmiqudamhliqusy

Mhfsuq db liah dn efyq 67* 68 fne 37 w.i. pium U. asx{i phsh

shldrhe* hlcheehe in dwuilfj axuuin` uhlwhsfuxsh lheixl

-Uiqqxh,Uho? Qfoxsf Udssfnah,AF)* fne qudshe in jivxie N3.

Illxndmiqudamhliqusy pfq whsbdslhe in eibbhshnu bsd{hn

uiqqxh qhauidnq pium hfam db umh bdjjdpin` fnuicdeihq; sfcciu

I`@ fnui,ldxqh NDq3* sfu fnui,ldxqh AE=* sfu fnui,ldxqh

AE5* `dfu fnui,ldxqh IBN,`* ds sfcciu wdjyajdnfj qhsxl fnui,

U. asx{i* fjj eijxuhe in wmdqwmfuh cxbbhshe qfjinh adnufinin` 1(

-p$r) db ndnbfu esy lijo. Umh qufinin` pfq whsbdslhe fri,

einhwhsd}iefqh adlwjh} fne 1* 17,eiflindchn{ieinh -EFC*

Rhauds Jfcdsfudsihq* Cxsjin`flh* Afnfef)* fne adxnuhs,qufinin` pium Lfyhsq mhlfud}yjin. F qhli,vxfnuiufuirh

lhumde qilijfs ud umfu bds wiasdqisixq she pfq whsbdslhe in

U. asx{i illxndqufinhe uiqqxhq. In umh afqh db AE5* AE=* fne

IBN,`* umh nxlchs db qufinhe ahjjq in f st}he fshf db 87

qvxfshe liasdlhuhsq pfq adxnuhe.

3.0. Qufuiquia fnfjyqiq

Shqxjuq fsh h}wshqqhe fq lhfnq QHL db umshh inehwhn,

ehnu h}whsilhnuq. Quxehnuq u,uhqu pfq xqhe ud fnfjy{h umh

qufuiquiafj qi nistafnah db umh dcqhsrhe eibbhshnahq. Umh

Ofwjfnh

Lhihs lhumde pfq xqhe ud adlwfsh qxsrirfj uilhq dbumh quxeihe `sdxwq. Rfjxhq dbW 7.78-+)ds W 7.76-++) phsh

adnqiehshe qi`nistafnu.

1. Shqxjuq

1.6. Wsdexauidn db JUC5 in afseifa uiqqxh db liah in umh

faxuh wmfqh db inbhauidn pium U. asx{i

Bisqu ph fqohe ib JUC5 iq wsdexahe in umh afseifauiqqxh exsin`

umh faxuh wmfqh db U. asx{i inbhauidn. Umh jhrhjq db JUC5 phsh

lhfqxshe in mhfsu mdld`hnfuhq bsdl liah chjdn`in` ud hfam

`sdxw fu eibbhshnu uilh wdinuq fbuhs inbhauidn ds in ndu inbhauhe

adnusdj. Umh shqxjuq qmdphe umfu in PU liah umh wsdexauidn db

JUC5 iq `sfexfjjy inashfqhe fjdn` umh inbhauidn* whfoin` in efy

68 w.i.* fne qufsuq ud eiliniqm dn efy 37 w.i. In feeiuidn* umh jhrhjq

db JUC5 in mhfsuq bsdl inbhauhe 8,JD$ liah phsh fcdrh

cfqhjinh bsdl adnusdj ndu inbhauhe liah* ajhfsjy ineiafuin` umfu

JUC5 iq wshqhnu in umh mhfsu exsin` umh inbhauidn pium U. asx{i fne

umfu iuq wsdexauidn iq ehwhnehnu db 8,JD -Bi`. 6F).

1.3. Qxsrirfj fne wfsfqiuhlif db PU fne 8,JD$ liah

inbhauhe pium U. asx{i

Ud feeshqq umh shjhrfnah db 8,JD fauiriuy in umh shqiqufnah

ud umh inbhauidn* wfsfqiuhlif fne qxsrirfj fnfjyqhq db PU fne

8,JD$ liah inbhauhe pium U. asx{i phsh hrfjxfuhe. Umh

ehstaihnay db 8,JD hn{ylh shqxjuhe in usfnqihnu* hnmfnahe fne

qji`mujy fnuiaiwfuhe whfo db wfsfqiuhlif adlwfshe pium umh

adnusdj `sdxw -9um fne 66um efyq w.i.* shqwhauirhjy? Bi`. 6C).

Mdphrhs* cdum `sdxwq db fnilfjq famihrhe umh adlwjhuh

Bi`. 6. Wsdexauidn db JUC5 in inbhauhe U. asx{i liah fne umh inrdjrhlhnu db 8,

JD in adnusdj db wfsfqiuhq wsdjibhsfuidn. Umh jhrhjq db JUC5 in umh mhfsu

mdld`hnfuh bsdl PU fne 8,JD$ liah inbhauhe ds ndu pium U. asx{i -F)*.

Umh efqmhe jinh shwshqhnuq umh jhrhjq db JUC5 in mhfsu bsdl adnusdj -ndu

inbhauhe) liah. Umh wfsfqiuhlif -C) fne ldsufjjy -A) db inbhauhe PU ds 8,

JD$ fsh qmdphe. Umh efuf qmdphe shwshqhnu umh lhfn QHL db umh shqxjuq

dcufinhe xqin` strh liah fne fsh shwshqhnufuirh db umshh inehwhnehnu h}whsi,

lhnuq. +W : 7.78 adlwfshe pium inbhauhe liah.

8=9P.S. Wfrfnhjji hu fj. $ Liasdchq fne Inbhauidn 63 -3767) 8=0h890


4/11

adnusdj db wfsfqiuhlif fbuhs 60 w.i. efyq. Ehqwiuh umh adnusdj db

wfsfqiuhlif in cdum `sdxwq* umh qxsrirfj db 8,JD$ liah pfq

qi`nistafnujy mi`mhs. Fjj PU liah qxaaxlche ud inbhauidn cy

efy 17 w.i.* pmijh fu umh qflh uilh f qufcjh qxsrirfj sfuh db

28( pfq dcqhsrhe -Bi`. 6A).

1.1. Hrfjxfuidn db mhfsu wfumdjd`y in PU fne 8,JD$

liah inbhauhe pium U. asx{i

Qinah JUC5 iq wsdexahe exsin` umh inbhauidn fne 8,JD$

liah fsh ldsh shqiqufnu ud umh inbhauidn* ph nh}u h}flinhe ib

umh inuhnqiuy db lydafseiuiq pfq fqqdaifuhe pium umiq wsdin,

ffifllfudsy ldjhaxjh. Fu efy 67 w.i.* umh lydafseixl db PU

fne 8,JD$ liah qmdphe f qilijfs lije lydafseiuiq* amfs,

fauhsi{he cy f eiqashuh inuhsquiuifj inffifllfudsy instjusfuh

adlwdqhe lfinjy db jylwmdldndnxajhfs ahjjq. Fu efy 68 w.i.*

PU liah wshqhnuhe f qhrhsh lydafseiuiq fqqdaifuhe pium fn

inffifllfudsy instjusfuh lfinjy adlwdqhe db jylwmdldnxajhfs

ahjjq. In adnusfqu* umh lydafseixl db 8,JD$ liah qmdphe

f ldehsfuh lydafseiuiq fjqd faadlwfnihe cy fn inffifllfudsyinstjusfuh db jylwmdldndnxajhfs ahjjq. Fu efy 37 w.i.* umh

lydafseixl bsdl PU liah wshqhnuhe f qusioin`jy qhrhsh

lydafseiuiq* fqqdaifuhe pium fn inffifllfudsy instjusfuh

adlwdqhe db jylwmdldndnxajhfs ahjjq. In adnusfqu* umh

lydafseixl bsdl 8,JD$ liah qmdphe f ldehsfuh

lydafseiuiq -Bi`. 3F). In bfau* umh fnfjyqiq db inffifllfudsy

qadsh db afseifa uiqqxhq bsdl cdum liah `sdxwq qmdphe

f qi`nistafnu ehashfqhe jhxodayuia instjusfuidn in umh 8JD$

inbhauhe liah* adlwfshe pium PU liah -Bi . 3C). Umhqh

shqxjuq qx``hqu umfu 8,JD wjfyq f sdjh in umh wfumd`hnhqiq db

faxuh lydafseiuiq exsin` U. asx{i inbhauidn.

1.5. Ehuhauidn db U. asx{i fnui`hnq fne adjjf`hn

ehwdqiuidn in afseifa uiqqxhq db PU fne 8,JD$

inbhauhe liah

Ph nh}u hrfjxfuhe ib umh shexahe inffifllfuidn dcqhsrhe in

8,JD$ liah hbbhauq wfsfqiuh ajhfsfnah db umh lydafseixl.

Illxndmiqudamhliqusy bds ehuhauidn db wfsfqiuh fnui`hnq

ehldnqusfuhe f exfj hbbhau db 8,JD ehstaihnay dn uiqqxh

wfsfqiuiql. Bisqu* adlwfshe pium PU liah* 8,JD$ liah

eiqwjfyhe inashfqhe fldxnuq db U. asx{i fnui`hnq -fwwsd}i,

lfuhjy upd bdjeq) fu efy 68 w.i. In adnusfqu* fu umh efy 37 w.i.*

umh jhrhjq db wfsfqiuh fnui`hnq db 8,JD$ liah ehashfqhe

qi`nistafnujy adlwfshe pium PU liah -Bi`. 3A). Umhqh efuf

qx``hqu umfu fjumdx`m 8,JD$ liah mfrh f shexahe inffifl,

lfudsy shqwdnqh* umhy adnusdj umh wfsfqiuh jdfe in umh afseifa

uiqqxh. Umh adjjf`hn ehwdqiuidn dn afseifa uiqqxh pfq hrfjxfuhe

cy wiasdqisixq she qufinhe qhauidnq db mhfsu dn efyq 67* 68 fne

37 w.i. Efuf dcufinhe cy adnrhnuidnfj ds wdjfsi{fuidn liasdq,

adwy shrhfjhe lije inuhsquiuifj stcsdqiq in cdum PU fne 8,JD$

liah dn efyq 67 fne 68 w.i.. Umh stcsdqiq pfq lfnibhquhe cy

f eiqashuh inashfqh in umh fldxnu db whsilyqifj fne hnedlyqifj

adjjf`hn fq adlwfshe pium adnusdj mhfsuq bsdl ndninbhauhe

adnusdjq. Fu efy 37 w.i.* umh PU liah h}miciuhe f lfsohe

eibbxqh inuhsquiuifj lydafseifj stcsdqiq amfsfauhsi{he cy umiaohs

whsyliqifj adjjf`hn stchsq h}uhnein` inud umh hnedlyqixl in

adlwfsiqdn pium umh ldsh eiqashuh stcsdqiq in umh lydafseixl

bsdl 8,JD$ liah -Bi`. 1F). In bfau* umh vxfnuistafuidn db

lydafseifj stcsdqiq in mhfsu qhauidnq db cdum `sdxwq db liah

shrhfjhe umfu in `hnhsfj* umh stcsdqiq pfq ldsh nduiahfcjy dn

efy 37 w.i. umfn in wshridxq whsideq. Db nduh* umh rdjxlh

bsfauidn db stcsdqiq pfq nhfsjy upd uilhq mi mhs in umh

lydafseixl bsdl PU umfn umfu bsdl 8,JD$

liah dn 37 efyw.i. -Bi`. 1C). Umhshbdsh* umhqh shqxjuq qxwwdsu umh mywdumhqiq

umfu umh fcqhnah db JUq fcsd`fuhe umh inffifllfudsy shqwdnqh

fne stcsdqiq in afseifa uiqqxh db U. asx{i inbhauhe liah.

1.8. Amfsfauhsi{fuidn db umh inffifllfudsy instjusfuh in

lydafseif db PU fne 8,JD$ U. asx{i,inbhauhe liah

Umh wmhnduywh db jylwmdayuhq umfu li`sfuhe ud umh afseifa

uiqqxh db 8,JD$ liah pfq ehuhslinhe cy illxndmiqud,

amhliqusy. Umh shqxjuq ehldnqusfuhe f wsd`shqqirh inashfqh db

AE5 fne AE= ahjjq in umh mhfsu db PU liah fjdn` umh

fnfjy{he uilh wdinuq. In 8,JD$ liah* ehqwiuh ud faaxlxjfuh

jhxodayuhq inud umh afseifa uiqqxh* umh fldxnu pfq qi`nistafnujyjdphs adlwfshe pium umfu db inbhauhe PU liah in fjj uilh wdinuq

quxeihe -Bi`.5FfneC).Fjqd*umhnxlchsdbIBN,` wdqiuirh ahjjq

inashfqhe `sfexfjjy fjdn` umh uilh in PU liah* cxu ndu in 8,

JD$ liah -Bi`. 5A). Ud`humhs* umhqh shqxjuq adnstsl f shexa,

uidn in umh nxlchs db jhxodayuhq in umh inffifllfudsy jhqidnq db

mhfsu db 8,JD$ liah inbhauhe pium U. asx{i.

1.2. Wsdexauidn db ayudoinhq fne ND in PU fne 8,JD$

liah inbhauhe pium U. asx{i

Ud bxsumhs quxey umh inffifllfudsy shqwdnqh in umh mhfsu*

jirhs fne qwjhhn db PU fne 8,JD$

liah* ph hrfjxfuhe umhwsdexauidn db UNB,f* IBN,`* IJ,67* fne IJ,5 in uiqqxhq bsdl

inbhauhe PU fne 8,JD$ liah. Umh shqxjuq qmdphe umfu umh

wsdexauidn db UNB,f* IBN,`* fne IJ,5 in umh mhfsu fne jirhs

phsh mi`mhs dn efyq 68 fne 37 w.i. in PU adlwfshe pium 8,

JD$,inbhauhe liah. In feeiuidn* mi`mhs UNB,f fne IJ,5

adnahnusfuidn -cxu ndu IBN,`) pfq fjqd ehuhauhe in umh qwjhhnq

db PU liah. Adnrhsqhjy* umh IJ,67 wsdexauidn pfq qi`nist,

afnujy jdphs in jirhs db inbhauhe,PU liah adlwfshe pium 8,

JD$ liah dn efyq 68 fne 37 w.i. -Bi`. 8). In faadsefnah* umh

illxndqufinin` bds niusia d}ieh qynumfqh -iNDQ) pfq jdphs in

umh mhfsu uiqqxh db 8,JD$ umfn umfu db PU inbhauhe liah

-Bi`. 2F). Umiq efuf adsshjfuhe pium umh inashfqhe jhrhjq db

niusiuh fne niusfuh bdxne in umh qhsf db PU liah -Bi`. 2C). Umiq

shexahe wsdexauidn db wsdinffifllfudsy ayudoinhq fne ND*

fjdn` pium inashfqhe jhrhjq db umh fnui,inffifllfudsy ayudoinh

IJ,67* h}wjfin umh shexahe afseifa inffifllfudsy shqwdnqh in

8,JD$ liah inbhauhe pium U. asx{i.

5. Eiqaxqqidn

Jiwie lheifudsq qxam fq JUq fne wsdquf`jfneinq wfsuiaiwfuh

in umh shasxiulhnu db jhxodayuhq ud umh inffiflhe uiqqxh _3=*39\.

Umhqh lheifudsq fsh wsdexahe bsdl fsfamiednia faie cy hiumhs

umh ayajdd}y`hnfqh wfumpfy -jhfein` ud wsdquf`jfneinq fne

umsdlcd}fnhq) ds umh 8,JD wfumpfy ud bdsl JUq. Ph mfrh

897 P.S. Wfrfnhjji hu fj. $ Liasdchq fne Inbhauidn 63 -3767) 8=0h890


5/11

wshridxqjy qmdphe umfu umh ushfulhnu db inbhauhe liah pium umh

AD],3 inmiciudsq qdeixl qfjiayjfuh ds lhjd}iafl esflfui,

afjjy shexahe umh cjdde wfsfqiuhq jdfe fne ehjfyhe umh ehfum

axsrh db umh inbhauhe fnilfjq. Ldshdrhs* umiq ushfulhnu

shqudshe umh wsdexauidn db IJ,3 ud adnusdj jhrhjq fne

jylwmdayuh wsdjibhsfuidn. Umhqh efuf wdinuhe dxu f sdjh bds

W@H3 in lheifuin` umh illxndqxwwshqqidn daaxssin` in

h}whsilhnufj U. asx{i inbhauidn _17\. Mhsh ph fuuhlwuhe ud

hrfjxfuh umh fbbhau db umh ehstaihnay db fndumhs lhufcdjia

wfumpfy bds fsfamiednia faie; umh 8,JD hn{ylh.

Umh lydafseifj inffifllfudsy shqwdnqh dcqhsrhe exsin`

U. asx{i inbhauidn iq hqqhnuifj bds hjilinfuin` umh wfsfqiuh cxu

fjqd faadxnuq bds umh h}uhnqirh uiqqxh eflf`h fne qxcqhvxhnu

ldscieiuy _1*16\. Dxs shqxjuq qx``hqu umfu h}fahscfuhe

lydafseiuiq iq ehusilhnufj ud umh mdqu exsin` umh faxuh wmfqh db

umh inbhauidn. JUq fsh hqqhnuifj in umh oijjin` db U. asx{i cy in

riusd inbhauhe lfasdwmf`hq _69\. Ldshdrhs* umh ushfulhnu db

U. asx{i,inbhauhe liah pium f CJU6 shahwuds fnuf`dniqu pfq

faadlwfnihe cy inashfqhe wfsfqiuhlif* cxu ndu jhumfjiuy _31\.

In faadsefnah* dxs axsshnu efuf shrhfjhe fn inashfqhe JUC5wsdexauidn exsin` umh faxuh wmfqh dbU. asx{i inbhauidn. 8,JD$

,inbhauhe liah wshqhnuhe shexah jhxodayuh li`sfuidn ud umh

lydafseixl fne fjqd h}miciuhe f mi`mhs wfsfqiuia jdfe umfn

PU liah. Ehqwiuh umhqh bfauq* 8,JD$

,inbhauhe liah phsh

Bi`. 3. Miqudjd`iafj hrfjxfuidn fne U. asx{i fnui`hnq in mhfsu db U. asx{i,inbhauhe liah. PU fne 8,JD$ liah phsh inbhauhe pium U. asx{i fne umh mhfsu adjjhauhe*

st}he fne h}flinhe xnehs wmdudliasdqadwh. Shwshqhnufuirh wmdudliasd`sfwmq db mhfsuq bsdl PU fne 8,JD$ liah dn efyq 68 fne 37 w.i. pium U. asx{i fsh

qmdphe -F). Umh inffifllfudsy qadsh -C) fne umh whsahnuf`h dbU. asx{i fnui`hnq whs fshf in lydafseixl -A) fsh fjqd qmdphe. Umh efuf shwshqhnu umh lhfn QHL

db umh shqxjuq dcufinhe xqin` strh liah fne fsh shwshqhnufuirh db umshh inehwhnehnu h}whsilhnuq. + W : 7.78 adlwfshe pium inbhauhe PU liah. Qafjh cfsq 87 ll.

896P.S. Wfrfnhjji hu fj. $ Liasdchq fne Inbhauidn 63 -3767) 8=0h890


6/11

fcjh ud adnusdj wfsfqiuh cxsehn fne qxsrirhe ud umh amfjjhn`h.

Db nduh* qilijfs shqxjuq phsh dcufinhe in liah ushfuhe pium

LO==2* fn inmiciuds db JUq cidqynumhqiq -Qhh Qxwwjhlhnufsy

Bi`. 6).

Umh inffifllfudsy shqwdnqh in umh mhfsu iq amfsfauhsi{he cy

umh instjusfuidn db lfasdwmf`hq* AE5* fne AE= jylwmdayuhq

umfu wsdexahq shfauirh qwhaihq db niusd`hn fne d}y`hn* fq phjj

fq ayudoinhq -lfinjy IBN,`* UNB,f* fne IJ,67). In qwiuh db

chin` nhahqqfsy bds wfsfqiuh oijjin` piumin wmf`dayuhq* niusia

d}ieh iq f adlwjh} lheifuds pmiam h}ahqqirh wsdexauidn* fq

adlldnjy dcqhsrhe exsin` U. asx{i inbhauidn* mfq chhn

qmdphe ud afxqh fwdwudqiq db inffifllfudsy ahjjq* fxudndlia

nhxsdnfj ahjjq fne afseidlydayuhq _30*13*11\* shqxjuin` in

illxnh qxwwshqqidn* h}uhnqirh uiqqxh ehqusxauidn _30*15\ fne

lfy hrhn bfaijiufuh umh wfsfqiuh qxsrirfj. Umh mi`m jhrhjq db

ND dcqhsrhe in PU liah dn 37 efy w.i adxje ilwfau umh

hbstaihnay db illxnh shqwdnqh* fjjdpin` umh wsdjibhsfuidn fne

whsqiquhnah db wfsfqiuh in umh uiqqxh. Umhshbdsh* jdphs ND

Bi`. 1. Afseifa stcsdqiq db PU fne 8,JD$ liah dn umh faxuh wmfqh db U. asx{i inbhauidn. PU fne 8,JD$ liah phsh inbhauhe pium U. asx{i* hxumfni{he* fne umh

mhfsuq wsdahqqhe bds ehuhauidn db adjjf`hn. Umh wmdudliasd`sfwmq db afseifa uiqqxhq db liah qufinhe pium wiasdqisixq she fu efy 37 w.i. -F) fne umh vxfnuistafuidn dbadjjf`hn ehwdqiuidn -C) fsh qmdphe. Umh efuf shwshqhnu umh lhfn QHL db umh shqxjuq dcufinhe xqin` strh liah fne fsh shwshqhnufuirh db umshh inehwhnehnu

h}whsilhnuq. +W : 7.78 adlwfshe pium inbhauhe PU liah. Qafjh cfsq 687 ll.



7/11

wsdexauidn fq umfu dcqhsrhe 8,JD$,inbhauhe liah adxje ch

hndx`m ud adnusdj wfsfqiuh shwjiafuidn frdiein` h}uhnqirh

lydafseifj eflf`h.

Inbhauhe 8,JD$ liah h}miciuhe shexahe jhrhjq db jhxod,

ayuhq fne ayudoinhq in umh lydafseixl fne fjqd qmdpheshexahe

jhrhjq db lydafseifj stcsdqiq fu f jfuh quf`h db faxuh wmfqh db umh

inbhauidn -efy 37 w.i.)* pmiam iq f ajhfs adnqhvxhnah db umh

ehashfqhe uiqqxh ehqusxauidn. Umxq* in feeiuidn ud umh wsdexauidn

db ayudoinhq fne amhldoinhq _1\ dcqhsrhe exsin` umh rhsy hfsjy

quf`hq db afseifa inffifllfuidn* umh jiwie lheifudsq ehsirhe bsdl

8,JD lhufcdjiql* hqwhaifjjy JUC5* wfsuiaiwfuh in umh inexauidn

db qxam inffifllfudsy eflf`h inud wfsfqiui{he afseifa uiqqxhq

exsin` umh inbhauidn pium U. asx{i. Inehhe* iu pfq shahnujy

ehldnqusfuhe umfu 8,JD wsdexauq fsh shqwdnqicjh bds d}iefuirh

qushqq in hsyumsdayuhq exsin` umiq inbhauidn _18\.

Umh cidjd iafjjy fauirh wsdexauq db fsfamiednia faie

d}iefuidn cy 8,JD wjfy f sdjh in umh wfumd`hnhqiq db rfsidxq

inffifllfudsy eiqdsehsq jioh fqumlf _12\* ayquia stcsdqiq _10\

wqdsifqiq _1=\* smhxlfudie fsumsiuiq _19\* fne inffifllfudsy

cdphj eiqhfqh _57\. Fldn` umhqh lheifudsq* JUq fsh ondpn ud

wfsuiaiwfuh fauirhjy in umh adnusdj db inbhauidnq cy wsdud{df* fq

ehldnqusfuhe in qhrhsfj quxeihq _56h

51\. Ehqwiuh umfu JUC5fne JUA5 mfrh chhn qmdpn ud wfsuiaiwfuh in wfsfqiuh xwufoh

fne oijjin` cy wmf`dayuhq fne afseifa lydcjfqu in riusd

_69*55\* umh sdjh db umhqh ldjhaxjhq in mdqu shqiqufnah fne

inexauidn db lydafseiuiq exsin` U. asx{i inbhauidn shlfinq

xnondpn. JUC5 wsdlduh umh shasxiulhnu db inffifllfudsy ahjjq

inajxein` fauirfuhe AE5 fne AE= U jylwmdayuhq _39\* fne

adnusicxuh ud inashfqh umh xwufoh fne inusfahjjxjfs ehqusxauidn

db U. asx{i* fq phjj fq umh wsdexauidn db IBN,` fne ND cy

wmf`dayuhq _31*55\. Xnjioh JUC5* umh ayq,JUq-JUA5) ed ndu

inexah jhxodayuh li`sfuidn inud inffiflhe uiqqxh* cxu adnusicxuh

ud inffifllfuidn rif inashfqhe rfqaxjfs whslhfcijiuy fne

qxcqhvxhnu hehlf _58\. Ldshdrhs* umhy mfrh fjqd chhn

ehqasiche fq ehusilhnufj bfaudsq ud mhfsu adnusfauijiuy _5\.Umxq* umh fcqhnah db 8,JD qhhlq ud wshrhnu umh mfslbxj

hbbhauq db umhqh lheifudsq dn mhfsu adnusfauijh bxnauidn. In

feeiuidn ud JUq* jiwd}inq -J}) fsh fjqd ehsirhe bsdl fsfam,

iednia faie lhufcdjiql fne mfrh fn fnuf`dniquia sdjh* inmic,

iuin` inffifllfudsy shfauidnq _52\. Umh sdjh db J} in

ehuhslinin` umh lydafseifj inffifllfuidn pfq ndu quxeihe*

fjumdx`m dxs shqxjuq qmdp umfu umh ehstaihnay in 8,JD ed ndu

fwwhfsq ud drhspmhjlq qi`nistafnujy umh wsdexauidn db J}* fq

umh wshedlinfnu hbbhau dcqhsrhe in 8,JD$ liah iq f shexahe

afseifa inffifllfuidn. Mdphrhs* qwhaista inmiciuidn db J}

qmdxje mhjw ud ajfsiby qhwfsfuhjy umh sdjh db umhqh fnui,

inffifllfudsy jiwie lheifudsq in umh lydafseiuiq inexahe cyU. asx{i.

Umh inashfqhe fldxnuq db wfsfqiuhq usfnqihnujy dcqhsrhe in

umh cjdde fne in umh afseifa uiqqxh db 8,JD$ liah -dn efyq 9

fne 68 w.i.* shqwhauirhjy) fsh wsdcfcjy exh ud umh shexahe

jhrhjq db ND in qhsxl* fq phjj fq eiliniqmhe li`sfuidn db

AE5 fne AE= U ahjjq ud umh lydafseixl* in feeiuidn ud

shexahe wsdexauidn db IBN,`. Fjj umhqh bfaudsq fsh hqqhnuifj bds

adnusdjjin` U. asx{i shwjiafuidn. F shwdsu xqin` umh 8,JD

inmiciuds ndseimyesd`xfifshuia faie -NE@F) qmdphe qilijfs

shqxjuq in uhslq db wfsfqiuhlif fne uiqqxh wfsfqiuiql _18\.

Inehhe* liah jfaoin` AE5 ds AE= ahjjq* fq phjj fq IBN,`

wsdexain` ahjjq* fsh inafwfcjh ud adnusdj umh inbhauidn

_0*50*5=\. Nhrhsumhjhqq* 8,JD$ liah phsh jfqujy fcjh ud

adnusdj umh wfsfqiuh cxsehn in umh aisaxjfuidn fne in umh afseifa

uiqqxh -dn efyq 61 fne 37 w.i.* shqwhauirhjy). Umhqh efuf fsh in

faadsefnah pium wshridxqjy wxcjiqmhe shwdsuq umfu inmiciuidn db

JUC5 -dnh wsdexau db 8,JD) pfq faadlwfnihe cy mi`mhs

jhrhjq db wfsfqiuhlif* cxu ndu jhumfjiuy in liah inbhauhe pium U.

asx{i _31\.

Dxs shqxjuq ajhfsjy qmdp umfu 8,JD$ liah wshqhnu shexahe

ineh} db stcsdqiq fqqdaifuhe ud jdp jhrhjq db IJ,5 fne UNB,

f adlwfshe pium PU liah. Umhqh ayudoinhq fsh shjhfqhe cy

inffifllfudsy ahjjq fne wsdlduh stcsdqiq _38*59\. IJ,5

wsdlduhq wsd`shqqidn db stcsdqiq cy quilxjfuin` umh qynumhqiq

db adjjf`hn _87\. In feeiuidn ud UNB,f fne IJ,5* U@B,c iq

Bi`. 5. AE5* AE=* fne INB,` ahjjq in afseifa uiqqxh db PU fne 8,JD$

liah inbhauhe pium U. asx{i. AE5 -F)* AE= -C) fne INB,` ahjjq -A) phsh

vxfnuisthe in bsd{hn qhauidnq db afseifa uiqqxh wsdahqqhe bds illxndmiqud,

amhliqusy. Umh efuf shwshqhnu umh lhfn QHL db umh shqxjuq dcufinhe xqin`

strh liah fne fsh shwshqhnufuirh db umshh inehwhnehnu h}whsilhnuq. +W : 7.78

adlwfshe pium inbhauhe PU liah.



8/11

f phjj ondpn wsd,stcsduia ayudoinh pmiam wjfyq f wsdlinhnu

sdjh in umh qusxauxsfj fjuhsfuidnq afxqhe cy U. asx{i fu jfuhs

quf`hq db inbhauidn _86\. Bxsumhs inrhqui`fuidnq bdaxqhe dn umh

amsdnia mhfsu wfumdjd`y qmdxje ehldnqusfuh ib fcqhnah db 8,

JD afn jhfe ud shexahe lfusi} shldehjin fne whsmfwq

shexahe amsdnia ldscieiuy.

Umh fcqhnah db 8,JD shqxjuq in ehashfqhe wsdexauidn db

wsdinffifllfudsy ayudoinhq -UNB,f fne INB,`)* cxu eie ndu

qi`nistafnujy hnmfnah umh jhrhjq db umh fnui,inffifllfudsy

ayudoinh IJ,67 in umh mhfsu. Db nduh* umh hbbhau db 8,JD ehst,

aihnay in umh wsdexauidn db ayudoinhq iq umh qflh in afseifa

fne mhwfuia uiqqxh* pmhshfq in umh qwjhhnq bsdl 8,JD$ liah

dnjy UNB,f iq qi`nistafnujy shexahe. Umxq* feehe ud umh ahnusfj

sdjh db JUq in shasxiuin inffifllfudsy ahjjq* umhqh jiwie

lheifudsq fsh fjqd ilwdsufnu ldexjfudsq db umh ayudoinh

hnrisdnlhnu wsdexahe exsin` U. asx{i inbhauidn.

In adnajxqidn* dxs stnein`q qx``hqu umfu exsin` h}whsilhnufj

inbhauidn pium U. asx{i* umh wsdexauq db 8,JD fauiriuy fsh shvxishe

cxu ndu hqqhnuifj bds umh adnusdj db qyquhlia fne afseifa wfsfqiuh

cxsehn cy illxnh ahjjq. Ldsh ilwdsufnu* umiq quxey wsdriehq

hriehnah umfu fwfsu bsdl chin` umh inuhnqiuy db umh lydafseifj

inffifllfuidn ehuhslinfnu bds adnusdj umh `sdpum db umh wfumd`hn*

iu afn fjqd ch fqqdaifuhe pium faxuh ldsufjiuy. Adnqhvxhnujy* iu iq

wdqqicjh umfu umhsfwhxuia fwwsdfamhq filin` ud shexah umh

inuhnqiuy db lydafseiuiq* in adlcinfuidn pium fnui,wfsfqiuia

umhsfwy* adxje ch xqhbxj ud adnusdj U. asx{i,inexahe lydafseifj

eflf h fne umh shqxjuin` ldscieiuy. Fjumdx`m bxsumhs quxeihq fsh

shvxishe dn umhqh iqqxhq* umiq shwdsu adnquiuxuhq fn inahnuirh ud

Bi`. 8. Wsdexauidn db IBN,`* UNB,f* IJ,67* fne IJ,5 in umh mhfsu* jirhs* fne qwjhhn db PUfne 8,JD $ liah inbhauhe pium U. asx{i. Umh uiqqxhq db PU fne 8,JD$

liah phsh mdld`hni{he in WCQ in wshqhnah db wsduhfqhq inmiciuds fne umh adnahnusfuidnq db IBN,`* UNB,f* IJ,67* fne IJ,5 hrfjxfuhe cy HJIQF. Umh efuf qmdphe

shwshqhnu umh lhfn QHL db umh shqxjuq dcufinhe xqin` strh liah fne fsh shwshqhnufuirh db umshh inehwhnehnu h}whsilhnuq. +W : 7.78 adlwfshe pium inbhauhe PU

liah.



9/11

bdaxq dn umh qhjhauirh inmiciuidn db 8,JD in umh ehrhjdwlhnu dbillxndldexjfudsy umhsfwihq exsin` umiq inbhauidn.

Faondpjhe`hlhnuq

Qxwwdsuhe cy Bxnefafd eh Flwfsd fg Whqvxiqf ed Hqufed

eh Qfd Wfxjd* Umh Lijjhnnixl Inquiuxuh bds Rfaainh Ehrhj,

dwlhnu fne Uhamndjd`y* fne Adnqhjmd Nfaidnfj eh Ehqhn,

rdjrilhnud Aihnustad h Uhandjd`iad.

Fwwhnei}. Qxwwjhlhnufsy efuf

Qxwwjhlhnufsy efuf fqqdaifuhe pium umiq fsuiajh afn ch bdxne

in umh dnjinh rhsqidn* fu edi;67.6762$k.liainb.3767.71.762.

Shbhshnahq

_6\ B. Odchsjh* Amf`fq eiqhfqh fne Amf`fq qynesdlhq; umh wfumdjd y db

Flhsiafn usywfndqdlifqiq. Fer. Wfsfqiudj. 2 -692=) 21h662.

_3\ L.F. Sdqqi* Liasdrfqaxjfs amfn hq fq f afxqh db amsdnia afseidlydw,

fumy in Amf`fq eiqhfqh. Fl. Mhfsu K. 637 -6) -6997) 311h312.

_1\ L.L. Uhi}hisf* S.U. @f{{inhjji* K.Q. Qijrf* Amhldoinhq* inffifllfuidn

fne Usywfndqdlf asx{i inbhauidn. Ushneq Wfsfqiudj. 6= -2) -3773)

323h328.

_5\ @. @dshjio* H. Cdsef* L. Wdqufn* Q. @dn{fjh{ Afwwf* J. Quhsin,Cdsef* U

jylwmdayuhq bsdl U. asx{i,inbhauhe liah fjuhs mhfsu adnusfauijiuy;

wfsuiaiwfuidn db fsfamiednia faie lhufcdjiuhq. K. Ldj. Ahjj. Afseidj. 35 -6)

-6993) 9h37.

_8\ ].Q. Amhn* K.S. Qmhjjhs* H.N. Kdmnqdn* A.E. Bxno* Sdjh db jhxodusihnhq

shrhfjhe cy ufs`huhe eiqsxwuidn db umh 8,jiwd}y`hnfqh `hnh. Nfuxsh 103

-2873) -6995) 609h

6=3.

Bi`. 2. Fauirfuidn db niusia d}ieh qynumfqh in afseifa uiqqxhq fne jhrhjq db niusia d}ieh in umh qhsf db liah exsin` inbhauidn pium U. asx{i. Umh inexaicjh niusia d}ieh

qynumfqh -iNDQ) pfq shrhfjhe in bsd{hn qhauidnq db afseifa uiqqxh wsdahqqhe bds illxndmiqudamhliqusy -F) fne adnahnusfuidn db niusiuh$niusfuh in qhsf bsdl PU fne

8,JD$ liah phsh ehuhslinhe cy umh @sihqq lhumde -C). Umh efuf qmdphe shwshqhnu umh lhfn QHL db umh shqxjuq dcufinhe xqin` strh liah fne fsh shwsh,

qhnufuirh db umshh inehwhnehnu h}whsilhnuq. +W : 7.78 adlwfshe pium inbhauhe PU liah. Qafjh cfsq 87 ll.

http://dx.doi.org/doi:10.1016/j.micinf.2010.03.016http://dx.doi.org/doi:10.1016/j.micinf.2010.03.016


10/11

_2\ S.F. Ei}dn* S.H. Eihmj* H. Dwfq* H. Sfneq* W.K. Riaohsq* K.B. Hrfnq* K.P.

@ijjfse* E.O. Lijjhs* Shvxishlhnu db f 8,jiwd}y`hnfqh,fauirfuin` wsduhin

bds jhxodusihnh qynumhqiq. Nfuxsh 151 -2388) -6997) 3=3h3=5.

_0\ K.A. Fjichsui* K.U. Qdxud* F.W. Lfsind* K. Jfnnhq,Rihisf* L.L. Uhi}hisf* K.

Bfschs* S.U. @f{{inhjji* K.Q. Qijrf* Ldexjfuidn db amhldoinh wsdexauidn

fne inffifllfudsy shqwdnqhq in inuhsbhsdn,`fllf, fne uxlds nhasdqiq

bfauds,S6,ehstaihnu liah exsin` Usywfndqdlf asx{i inbhauidn. Fl. K.

Wfumdj. 68= -5) -3776) 6511h6557.

_=\ F.W. Lfsind* F.F. Qijrf* W.R. Qfnudq* J.L. Winud* S.U. @f{inhjji* L.L.

Uhi}hisf* K. Jfnnhq,Rihisf* AA,amhldoinh shahwudsq; f wduhnuifj umhsf,

whxuia ufs hu bds Usywfndqdlf asx{i,hjiaiuhe lydafseiuiq. Lhl. Inqu.

Dqpfjed Asx{. 677 -Qxwwj. 6) -3778) 91h92.

_9\ K.A. Fjichsui* B.Q. Lfamfed* K.U. Qdxud* F.W. Aflwfnhjji* L.L. Uhi}hisf*

S.U. @f{{inhjji* K.Q. Qijrf* chuf,Amhldoinhq hnmfnah wfsfqiuh xwufoh fne

wsdlduh niusia d}ieh,ehwhnehnu liasdcidqufuia fauiriuy in lxsinh

inffifllfudsy lfasdwmf hq inbhauhe pium Usywfndqdlf asx{i. Inbhau.

Illxn. 20 -9) -6999) 5=69h5=32.

_67\ K.Q. Jhdn* E.L. Hn`lfn* Fxudillxniuy in Amf`fq mhfsu eiqhfqh. Inu. K.

Wfsfqiudj. 16 -8h2) -3776) 888h826.

_66\ B. Oihsq{hncfxl* Amf fq eiqhfqh fne umh fxudillxniuy mywdumhqiq.

Ajin. Liasdcidj. Shr. 63 -3) -6999) 367h331.

_63\ A.E. Bxno* Wsdquf`jfneinq fne jhxodusihnhq; ferfnahq in hiadqfndie

cidjd`y. Qaihnah 395 -885=) -3776) 6=06h6=08.

_61\ R. Oxlfs* N. Bfxqud* F. Fccfq* Sdccinq fne Adusfn. Wfumdjdìafj Cfqiq

db Eiqhfqh. P.C. Qfxnehsq Adlwfny* Wmijfehjwmif* WF* XQF* 3775.

_65\ W. Lfsuin* Q.K. Jhicdriam* Inffifllfudsy ahjjq exsin` pdxne shwfis; umh

`dde* umh cfe fne umh x`jy. Ushneq Ahjj. Cidj. 68 -66) -3778) 899h270.

_68\ K.J. @dxjhu* S.A. @sibstumq* W. Sxi{* S.B. Qwxsnhy* E.Q. Wiqhuqoy* C.M.

Odjjhs* U.L. Adbblfn* Ehstaihnay db 8,jiwd}y hnfqh fcdjiqmhq qh},

shjfuhe qxsrirfj eibbhshnahq in LSJ,jws$jws liah. K. Illxndj. 621 -6)

-6999) 189h122.

_62\ A.F. Sdx{hs* U. Qmili{x* C. Qflxhjqqdn* Dn umh nfuxsh db umh 8,jiw,

d}y`hnfqh shfauidn in mxlfn jhxodayuhq; amfsfauhsi{fuidn db

f lhlcsfnh,fqqdaifuhe quilxjfudsy bfauds. Wsda. Nfuj. Fafe. Qai. X.Q.F.

=3 -33) -69=8) 0878h0879.

_60\ L. Lxsfofli* K.B. Whnsdqh* Y. Xsfeh* O.B. Fxquhn* K.W. Fsl* Inuhsjhxoin

5 qxwwshqqhq a,oiu ji`fne,inexahe h}wshqqidn db ayudqdjia wmdqwmdjiwfqh

F3 fne wsdquf`jfnein hnedwhsd}ieh qynumfqh 3 fne umhis sdjhq in qhwfsfuhwfumpfyq db hiadqfndie qynumhqiq in ldxqh cdnh lfssdp,ehsirhe lfqu

ahjjq. Wsda. Nfuj. Fafe. Qai. X.Q.F. 93 -61) -6998) 2670h2666.

_6=\ P.S. Mhnehsqdn Ks.* Umh sdjh db jhxodusihnhq in inffifllfuidn. Fnn.

Inuhsn. Lhe. 636 -9) -6995) 2=5h290.

_69\ K.K. Pisum* B. Oihsq{hncfxl* Quilxjfudsy hbbhauq db jhxodusihnh C5 dn

lfasdwmf`h fqqdaifuidn pium fne inusfahjjxjfs ehqusxauidn db Usywfnd,

qdlf asx{i. K. Illxndj. 615 -1) -69=8) 69=9h6991.

_37\ C. Qflxhjqqdn* Jhxodusihnhq; lheifudsq db illheifuh mywhsqhnqiuiriuy

shfauidnq fne inffifllfuidn. Qaihnah 337 -5890) -69=1) 82=h808.

_36\ L. Sdjf,Wjhq{a{ynqoi* Eibbhshnuifj hbbhauq db jhxodusihnh C5 dn U5 fne

U= jylwmdayuh wmhnduywh fne illxndsh`xjfudsy bxnauidnq. K. Illx,

ndj. 618 -3) -69=8) 6180h6127.

_33\ L. Sdjf,Wjhq{a{ynqoi* J. Cdxrshuuh* E. @in sfq* L. @isfse* Iehnuistaf,

uidn db inuhsbhsdn,`fllf fq umh jylwmdoinh umfu lheifuhq jhxodusihnh

C5,inexahe illxndsh`xjfuidn. K. Illxndj. 619 -3) -69=0) 861h

860._31\ F. Ufjrfni* B.Q. Lfamfed* @.A. Qfnufnf* F. Ojhin* J. Cfsahjdq* K.Q. Qijrf*

L.L. Uhi}hisf* Jhxodusihnh C-5) inexahq niusia d}ieh qynumhqiq in Usy,

wfndqdlf asx{i,inbhauhe lxsinh lfasdwmf`hq fne lheifuhq shqiqufnah ud

inbhauidn. Inbhau. Illxn. 07 -=) -3773) 5350h5381.

_35\ R. Liamfijdpqoy* N.L. Qijrf* A.E. Sdamf* J.V. Rihisf* K. Jfnnhq,Rihisf*

S.U. @f{{inhjji* Wirdufj sdjh db inuhsjhxoin,63 fne inuhsbhsdn,`fllf f}iq

in adnusdjjin` uiqqxh wfsfqiuiql fne inffifllfuidn in umh mhfsu fne ahnusfj

nhsrdxq qyquhl exsin` Usywfndqdlf asx{i inbhauidn. Fl. K. Wfumdj. 689

-8) -3776) 6031h6011.

_38\ L.F. Sdqqi* Wfumdjd ia stcsdqiq fne adnnhauirh uiqqxh lfusi} in jhbu

rhnusiaxjfs mywhsusdwmy exh ud amsdnia fsuhsifj mywhsuhnqidn in mxlfnq.

K. Mywhsuhnq. 62 -0) -699=) 6716h6756.

_32\ H.S. Aflfs`dq* E.K. Bsfnad* A.L. @fsaif* F.W. Exusf* F.J. Uhi}hisf Ks.*

H. AmifsiAdnahi* A.S. Lfamfed* Inbhauidn pium eibbhshnu Usywfndqdlf

asx{i wdwxjfuidnq in sfuq; lydafseiuiq* afseifa qylwfumhuia ehnhsrfuidn*

fne inrdjrhlhnu db ei`hquirh ds`fnq. Fl. K. Usdw. Lhe. My`. 23 -8)

-3777) 275h263.

_30\ Q.C. @fsaif* K.Q. Wfxjf* @.Q. @idrfnnhuui* B. [hnmf* H.L. Sflfjmd* Q.

[xadjdud* K.Q. Qijrf* B.V. Axnmf* Niusia d}ieh iq inrdjrhe in umh jhqidnq db

umh whsiwmhsfj fxudndlia nhxsdnq dcqhsrhe in umh faxuh wmfqh db

h}whsilhnufj Usywfndqdlf asx{i inbhauidn. H}w. Wfsfqiudj. 91 -5) -6999)

696h690.

_3=\ A.M. Oil* Umh `shfuhs amhldufauia nhupdso bds jylwmdayuh usfbstaoin`;

amhldoinhq fne chydne. Axss. Dwin. Mhlfudj. 63 -5) -3778) 39=h175.

_39\ F.L. Uf`hs* Q.O. Csdljhy* C.E. Lhedbb* Q.F. Iqjfl* Q.E. Chsaxsy* H.C.

Bsihesiam* F.E. Afsfbdnh* S.H. @hsq{uhn* F.E. Jxquhs* Jhxodusihnh C5

shahwuds CJU6 lheifuhq hfsjy hbbhauds U ahjj shasxiulhnu. Nfu. Illxndj.

5 -67) -3771) 9=3h997.

_17\ L.F. Liamhjin* K.Q. Qijrf* B.V. Axnmf* Inexaicjh ayajdd}y hnfqh

shjhfqhe wsdquf`jfnein lheifuhq illxndqxwwshqqidn in faxuh wmfqh db

h}whsilhnufj Usywfndqdlf asx{i inbhauidn. H}w. Wfsfqiudj. 666 -3) -3778)

06h09.

_16\ [. Cshnhs* S.U. @f{{inhjji* Illxndjdìafj adnusdj dbUsywfndqdlf asx{i

inbhauidn fne wfumd hnhqiq db Amf fq eiqhfqh. Inu. Fsam. Fjjhs y.

Illxndj. 665 -3) -6990) 671h667.

_13\ I.F. Fcsfmflqdmn* S.J. Adbblfn* Ayudoinh fne niusia d}ieh sh`xjfuidn

db umh illxndqxwwshqqidn in Usywfndqdlf asx{i inbhauidn. K. Illxndj.

688 -=) -6998) 1988h1921.

_11\ @.F. Lfsuinq* L.F. Afsedqd* K.A. Fjichsui* K.Q. Qijrf* Niusia d}ieh,

inexahe fwdwuduia ahjj ehfum in umh faxuh wmfqh db Usywfndqdlf asx{i

inbhauidn in liah. Illxndj. Jhuu. 21 -3) -699=) 661h637.

_15\ V. Bhn`* ]. Jx* E.J. Kdnhq* K. Qmhn* K.L. Fsndje* Inashfqhe inexaicjh

niusia d}ieh qynumfqh h}wshqqidn adnusicxuhq ud lydafseifj eyqbxnauidn

fne mi`mhs ldsufjiuy fbuhs lydafseifj inbfsauidn in liah. Aisaxjfuidn 675

-2) -3776) 077h075.

_18\ A.J. Cds`hq* S. Ahaamini* R.J. Ufufoimfsf* F.E. Lfjrh{i* Q.B. Yflfef,

D`fuuf* J.R. Si{{d* W. Win`h,Bijmd* 8,Jiwd}y`hnfqh wjfyq f sdjh in umh

adnusdj db wfsfqiuh cxsehn fne adnusicxuhq ud d}iefuirh eflf`h db

hsyumsdayuhq in lxsinh Amf`fq eiqhfqh. Illxndj. Jhuu. 631 -6) -3779)

1=h58.

_12\ Q.W. Whuhsq* W.Q. Ashuiadq* S.L. Nfajhsid* S.W. Qamjhilhs* E.P.

Lfa@jfqmfn Ks.* N.B. Feoinqdn Ks.* W.Q. Ndslfn* J.L. Jiamuhnquhin* I`H,

lheifuhe jhxodusihnh shjhfqh in riusd fne in rird. Usfnq. Fqqda. Fl.Wmyqiaifnq. 90 -69=5) 327h320.

_10\ L.P. Odnqufn* S.P. Pfjhn`f* O.F. Mijjifse* K.C. Mijjifse* Jhxodusihnh

C5 lfsohejy hjhrfuhe in umh hwiumhjifj jinin` ffixie db wfuihnuq pium ayquia

stcsdqiq. Fl. Shr. Shqwis. Eiq. 65= -5 Wu 6) -6991) =92h976.

_1=\ Q.E. Csfin* S.E. Aflw* B.L. Axnnin mfl* W.L. Edpe* L.P. @shfrhq*

F.O. Cjfao* Jhxodusihnh C5,jioh lfuhsifj in qafjh db wqdsifuia qoin

jhqidnq. Cs. K. Wmfslfadj. =1 -6) -69=5) 161h160.

_19\ N. Fmlfe{fehm* L. Qmin x* L. Ndcxnf`f* U. Ufpfsf* Shjfuidnqmiw

chuphhn jhxodusihnh C5 fne illxndjdìafj wfsflhuhsq in smhxlfudie

qyndrifj ffixieq. Inffifllfuidn 68 -2) -6996) 590h871.

_57\ W. Qmfsdn* P.B. Quhnqdn* Hnmfnahe qynumhqiq db jhxodusihnh C5 cy

adjdnia lxadqf in inffifllfudsy cdphj eiqhfqh. @fqusdhnuhsdjd`y =2 -1)

-69=5) 581h527.

_56\ P.S. Mhnehsqdn Ks.* H.Y. Ami* Umh ilwdsufnah db jhxodusihnhq in lfqu

ahjj,lheifuhe Ud}dwjfqlf `dneii ayudud}iaiuy. K. Inbhau. Eiq. 600 -8)-699=) 6510h6551.

_53\ A.M. Qhsh{fni* K.M. Whsshjf* L. Sxqqd* L. Whuhsq,@djehn* Q. Kfnafs*

Jhxodusihnhq fsh hqqhnuifj bds umh adnusdj db Jhiqmlfnif flf{dnhnqiq

inbhauidn fne adnusicxuh ud qusfin rfsifuidn in qxqahwuicijiuy. K. Illxndj.

600 -8) -3772) 1376h137=.

_51\ H.S. Lfamfed* L.U. Xhuf* H.R. Jdxshnad* B.B. Fnicfj* A.F. Qdsì* H.

@. Qdfshq* L.A. Sdvxh,Cfsshisf* F.I. Lhehisdq* J.M. Bfaaidji*

Jhxodusihnhq wjfy f sdjh in umh adnusdj db wfsfqiuh cxsehn in lxsinh

qusdn yjdieifqiq. K. Illxndj. 608 -2) -3778) 1=93h1=99.

_55\ K.K. Pisum* B. Oihsq{hncfxl* Hbbhauq db jhxodusihnh A5 dn lfasdwmf h

fqqdaifuidn pium fne inusfahjjxjfs bfuh db Usywfndqdlf asx{i. Ldj. Cid,

amhl. Wfsfqiudj. 68 -6) -69=8) 6h67.

_58\ Q.H. Efmjhn* K. Ckdso* W. Mhevriqu* O.H. Fsbdsq* Q. Mfllfsqusdl* K.F.

Jine shn* C. Qflxhjqqdn* Jhxodusihnhq wsdlduh wjfqlf jhfof h fne

jhxodayuh femhqidn in wdquafwijjfsy rhnxjhq; in rird hbbhauq pium



11/11

shjhrfnah ud umh faxuh inffifllfudsy shqwdnqh. Wsda. Nfuj. Fafe. Qai. X.Q.

F. 0= -2) -69=6) 1==0h1=96.

_52\ K. Fjichsui* Q. Mihny* A. Shiq h Qdxqf* A.N. Qhsmfn* F. Qmhs* Jiwd}in,

lheifuhe inmiciuidn db IJ,63 wsdexauidn cy EAq; f lhamfniql bds

sh`xjfuidn db liasdcifj illxniuy. Nfu. Illxndj. 1 -6) -3773) 02h=3.

_50\ W. Lindwsid* M. Hiqhn* L. Kdqodpia{* W. Whshisf* F. Adxuinmd* Qxwwshqqidn

db wdjyajdnfj fnuicdey wsdexauidn in Usywfndqdlf asx{i,inbhauhe liah cy

ushfulhnu piumfnui,J1U5 fnuicdeihq. K. Illxndj.619 -3) -69=0) 858h887.

_5=\ S.J. Ufsjhudn* K. Qxn* J. [mfn * L. Wdqufn* Ehwjhuidn db U,ahjj

qxcwdwxjfuidnq shqxjuq in h}fahscfuidn db lydafseiuiq fne wfsfqiuiql in

h}whsilhnufj Amf`fq eiqhfqh. Inbhau. Illxn. 23 -8) -6995) 6=37h6=39.

_59\ W.B. Wi`xhu* L.F. Adjjfsu* @.H. @sfx* Y. Ofwfnai* W. Rfqqfjji* Uxlds

nhasdqiq bfauds$afamhauin wjfyq f ohy sdjh in cjhdlyain,inexahe wnhx,

ldwfumy fne stcsdqiq. K. H}w. Lhe. 607 -1) -69=9) 288h221.

_87\ U.J. La@fmf* L. Jh* U. Odehsf* A. Qudiaf* K. [mx* P.H. Wfxj* A.F. Cdnf*

Ldjhaxjfs lhamfniqlq db inuhsjhxoin,5,inexahe xw,sh`xjfuidn db uywh I

adjjf`hn `hnh h}wshqqidn in lxsinh stcsdcjfquq. Fsumsiuiq Smhxl. 5= -=)

-3771) 3308h33=5.

_86\ E.J. Lfsuin* L. Wdqufn* W. Jxafq* S. @shqq* S.J. Ufsjhudn* U@B,chuf

sh xjfuhq wfumdjd y cxu ndu uiqqxh AE=U ahjj eyqbxnauidn exsin`

h}whsilhnufj Usywfndqdlf asx{i inbhauidn. Hxs. K. Illxndj. 10 -67)

-3770) 3025h3006.


5-lipoxygenase is a key determinant of acute myocardial inﬂammation and mortality during...

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