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5th SFRR-Asia, 8th ASMRM, 11th J-mit, 2011 Symposium Program

Wednesday, August 31st

16:00 – 18:00 Registration (The SECOND Hall) 18:30 – 21:00 Welcome Party (Cstle Park Hotel)

Thursday, September 1st

< THE SECOND HALL>

8:20 – 8:30 Opening Remarks 8:30 – 9:50 Invited Lectures Session 1 Chairperson: Young-Joon Surh (Seoul National University, Korea)

Michael J. Davies (The Heart Research Institute, Australia) (IL-1) REDOX MODULATION BY LIPID MEDIATORS WITH ANTI-INFLAMMATORY AND

PRO-RESOLVING ACTIVITIES Young-Joon Surh WCU Department of Molecular Medicine and Biopharmaceutical Sciences College of Pharmacy, Seoul National University, Seoul 151-742, Korea

(IL-2) INFLAMMATION, HEME PEROXIDASES AND DAMAGE TO BIOLOGICAL TARGETS

Michael J. Davies The Heart Research Institute, 7 Eliza Street, Newtown, Sydney, NSW 2042, Australia and Faculty of Medicine, University of Sydney, Sydney, NSW 2006, Australia

(IL-3) HOSCN INDUCES MACROPHAGE DYSFUNCTION BY TARGETING PROTEIN THIOLS

AND THE FORMATION OF SULFENIC ACIDS. Clare L. Hawkins Inflammation Group, Heart Research Institute, Newtown, NSW 2042, Australia.

(IL-4) F2-isoprostanes and F4-neuroprostanes in Non-traumatic Subarachnoid Hemorrhage in Humans

and Rats Hsiu-Chuan Yen Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Kwei-Shan, Taoyuan 333, Taiwan.

9:50 – 10:10 Coffee Break

10:10 – 11:10 Invited Lectures Session 2 Chairperson: Henrik E.Poulsen (University Hospital Copenhagen, Denmark)

Min-Xin Guan (Zhejiang University, China) (IL-5) Molecular pathogenesis of maternally transmittes hypertension.

Min-Xin Guan Institute of Genetics Zhejiang University, Hangzhou, Zhejiang 310058 China

(IL-6) MOLECULAR MECHANISM OF OXIDANT SIGNALING

Yuichiro Justin Suzuki Department of Pharmacology, Georgetown University Medical Center, Washington DC, 20057, USA.

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(IL-7) Oxidative stress to nucleic acids in diabetes and the metabolic syndrome. Henrik E. Poulsen Laboratory of Clinical Pharmacology Q7642, Rigshospitalet, University of Copenhagen. Blegdamsvej 9, DK-2100 Copenhagen, Denmark.


11:30 – 12:30 Invited Lectures Session 3

Chairperson: Hong Kyu Lee (Eulji University College of Medicine, Korea) Sasanka Chakrabarti (Institute of Post-graduate Medical Education & Research, India)

(IL-8) MECHANISMS AND CONSEQUENCES OF MITOCHONDRIAL DYSFUNCTION IN ADIPOSE TISSUE IN OBESITY AND TYPE 2 DIABETES

Sasanka Chakrabarti Department of Biochemistry, Institute of Post-graduate Medical Education & Research, 244, A J C Bose Road, Kolkata 700020, India

(IL-9) THEORETICAL FRAMEWORK TO EXPLAIN CARDIOVASCULAR DISORDERS WITH MITOCHONDRIAL DYSFUNCTION IN METABOLIC SYNDROME

Hong Kyu Lee Department of Internal Medicine, Eulji University College of Medicine, Seoul, Korea

(IL-10) Metabolism and incorporation of exogenous 8-oxodG into MCF-7 cells.

Paul T. Henderson Department of Internal Medicine, Division of Hematology and Oncology, University of California Davis, Sacramento, California, USA

12:50 – 13:50 Lunchon Seminar �

(Sponsored by Primetech Corporation)

Chairperson:

(LS-1) Flux analyses with solid-state sensors to assess cellular bioenergetics in age-related diseases David A. Ferrick Seahorse Biosciences, N. Billerica, MA, USA


Chairperson: Chang Chen (Institute of Biophysics Chinese Academy of Sciences, China)

Takaaki Akaike (Kumamoto University, Japan) (IL-11) Generation and actions of electrophilic nitro-fatty acids

Gustavo Bonacci Department of Pharmacology and Chemical Biology. School of Medicine. University of Pittsburgh, Pittsburgh 15261, USA.

(IL-12) FUNCTIONAL STUDY AND METHOD DEVELOPING OF S-NITROSATION

Chang CHEN National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, P.R. China.

(IL-13) LONG-LIVED REACTIVE OXYGEN INTERMEDIATES IN THE REACTION OF OZONE

WITH AEROSOL PARTICLES AND AEROSOL HEALTH EFFECTS Manabu Shiraiwa Department of Biogeochemistry, Max Planck Institute for Chemistry, 55128 Mainz, Germany

(IL-14) ENVIRONMENTAL POLLUTANTS INDUCE AGE-ASSOCIATED DISEASES THROUGH

MITOCHONDRIAL IMPAIRMENT Youngmi Kim Pak Department of Physiology, Department of Neuroscience, College of Medicine, Kyung Hee University, Seoul 130-701, Korea


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15:50 – 17:10 Invited Lectures Session 5 Chairperson: Kazuhiro Ichikawa (Kyushu University, Japan)

Yukio Nagasaki (University of Tsukuba, Japan) (IL-15) HIGH FIELD OMRI SCANNER FOR IMAGING IN VIVO FUNCTIONAL INFORMATION

Kazuhiro Ichikawa Innovation Center for Medical Redox Navigation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582 Japan

(IL-16) ASSESSMENT OF ANTIOXIDANT PROPERTY OF DRUGS USING ELECTRON SPIN

RESONANCE (ESR) SPECTROSCPY IN RODENT DISEASE MODEL Masaichi-Chang-il Lee Department of Clinical Care Medicine, Division of Pharmacology and ESR Laboratories, Kanagawa Dental College, Yokosuka, Japan, 238-8580, Japan.

(IL-17) SELF-ASSEMBLINE REDOX POLYMER DRUGS FOR NOVEL NANOTHERAPY

Yukio Nagasaki Department of Materials Science, Graduate School of Pure and Applied Sciences, Master’s School of Medical Sciences, Graduate School of Comprehensive Human Sciences, Principal Investigator, Strategic Initiatives (Project type), University of Tsukuba, 1-1-1 Ten-noudai, Tsukuba, Ibaraki 305-8573, Japan. Principal Investigator, Satellite Laboratory of International Center for Materials Nanoarchitechtonics, National Institute for Materials Science, Tsukuba, Japan.

(IL-18) SERUM MICRORNA COULD BE CANDIDATE BIOMARKERS FOR

HEPATOCELLULAR CARCINOMA Junhao Gui, Zhuhong Zhang, Pengjun Zhang, Yaping Tian1 Department of Clinical Biochemistry, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China

< THE CITIZEN’S HALL> 14:00 – 15:00 Young Investigator Awards Presentation Session 1 Chairperson: Hiroshi Ichikawa (Doshisha University, Japan) (YI-1) EXPRESSION OF NRF2, A POTENTIAL RENO-PROTECTIVE TRANSCRIPTION FACTOR,

IS REDUCED IN KIDNEY OF RATS WITH HYPERTENSION: EFFECT OF ANTIOXIDANT (HONEY) SUPPLEMENTATION

Omotayo O. Erejuwa1), Siti A. Sulaiman1), Mohd S. Ab Wahab1), Kuttulebbai N. S. Sirajudeen 2), Salzihan M. Salleh3), Sunil Gurtu4) 1)Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia. 2)Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia. 3)Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia. 4)Monash University Sunway Campus, Jeffrey Cheah School of Medicine and Health Sciences, Jalan Lagoon Selatan, 46150, Bandar Sunway, Selangor, Malaysia.

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(YI-2) ROLE OF NRF2 IN ADAPTIVE SURVIVAL RESPONSE TO HELICOBACTER PYLORI-INDUCED GASTRITIS

Hee Geum Lee1) and Young-Joon Surh1),2),3) 1) College of Pharmacy, Seoul National University, Seoul 151-742, South Korea 2) Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Sciences and Technology, Seoul National University, Seoul, South Korea 3) Cancer Research Institute, Seoul National University, Seoul 110-799, South Korea

(YI-3) Mitochondrial genome targeting strategy: mitochondrial matrix delivery of bio-macromolecule

using DF-MITO-Porter, an innovative nano carrier with cytoplasmic and mitochondrial fusogenic envelopes.

Yuma Yamada1), and Hideyoshi Harashima1) 1) Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.

(YI-4) The novel therapeutic strategy for mitochondrial DNA disease: A selective promotion of

wild-type mitochondrial DNA replication by a synthetic DNA-binding compound. Takamitsu Yano1), 2), Nono Takeuchi-Tomita2), Takeshi Wada2), Takuya Ueda2) 1 )Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8502, Japan 2)Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-856, Japan.

(YI-5) RECOMBINANT TFAM ATTENUATES PATHOLOGICAL REMODELING IN CARDIAC

MYOCYTES VIA INHIBITING NFAT SIGNALING Takeo Fujino1), Tomomi Ide1), Masayoshi Yoshida1), Atsushi Tanaka1), Ken Onitsuka1), Yuko Hata1), Takako Takehara1), Shinya Takazaki2), Motohiro Nishida3), Dongchon Kang2), and Kenji Sunagawa1) 1)Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812-8582, Japan 2)Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812-8582, Japan 3)Pharmacology and Toxicology, Kyushu University Graduate School of Pharmaceutical Sciences, Fukuoka 812-8582, Japan

15:00 – 15:15 Coffee Break 15:15 – 16:15 Young Investigator Awards Presentation Session 2 Chairperson: Ikuo Nakanishi (National Institute of Radiological Sciences, Japan) (YI-6) Regulation of monocyte function by tumor associated sialyl-Tn antigen through ROS production

Rina Takamiya1) , Kazuaki Ohtsubo1), Shinji Takamatsu1), Ken Shirato2) , Naoyuki Taniguchi1), Takashi Angata1) 1) Systems Glycobiology Research Group, Chemical Biology Department, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan, 2) Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa, Saitama 359-1192, Japan

(YI-7) ULTRAVIOLET SENSITIVE-5 GENE ENCODES THE MITOFUSIN IN NEUROSPORA

CRASSA Kiminori Kurashima, Michael Chae, Shuuitsu Tanaka, and Shin Hatakeyama Laboratory of Genetics, Faculty of Science, Saitama University, Saitama 338-8570, Japan

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(YI-8) RECENT STUDIES ON POSSIBILITY FOR ALLEVIATION OF OXIDATIVE DAMAGE AND INFLAMMATION BY LOW-DOSE IRRADIATION

Takahiro Kataoka1), Masaaki Yoshimoto1), Yuichi Nishiyama1), Junichi Teraoka1), Keiko Yamato1), Akihiro Saokda1),2), Takehito Tagichi1), and Kiyonori Yamaoka1) 1) Graduate School of Health Sciences, Okayama University, Okayama 700-8558, Japan 2) Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency, Okayama 708-0698, Japan

(YI-9) CRUCIAL ROLE OF MEMBRANE POTENTIAL IN HEAT STRESS-INDUCED

OVERPRODUCTION OF REACTIVE OXYGEN SPECIES IN SKELETAL MUSCLE MITOCHONDRIA

Motoi Kikusato and Masaaki Toyomizu Animal Nutrition, Life Science, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-amamiyamachi, Aoba-ku, Sendai 981-8555, Japan.

(YI-10) AMPK-MEDIATED INCREASE OF GLYCOLYSIS AS AN ADAPTIVE RESPONSE TO

OXIDATIVE STRESS IN HUMAN CELLS: IMPLICATION OF THE CELL SURVIVAL IN MITOCHONDRIAL DISEASES Shi-Bei Wu1) and Yau-Huei Wei1), 2) 1) Department of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei, Taiwan 2) Department of Medicine, Mackay Medical College, New Taipei City, Taiwan

17:30 – 18:30 Poster Presentation

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Friday, September 2nd

< THE SECOND HALL>

8:30 – 9:50 Invited Lectures Session 6 Chairperson: Julie K. Andersen (Buck Institute For Age Research, USA)

Kazutoshi Nakano (Tokyo Women’s Medical University, Japan) (IL-19) OXIDATIVE STRESS, ALPHA-SYNUCLEIN, AND EPIGENETIC AFFECTS IN THE

PARKINSONIAN BRAIN Julie K. Andersen Buck Institute for Research in Aging, 8001 Redwood Blvd, Novato, CA 94949, USA.

(IL-20) ANTI-OXIDATIVE AND ANTI-APOPTOTIC MECHANISMS OF MINOCYCLINE

AGAINST SPHINGOMYELINASE/CERAMIDE TOXICITY IN RAT CORTICAL NEURONS

Ding-I Yang Institute of Brain Science, National Yang-Ming University, Taipei, 11221, Taiwan.

(IL-21) THE EFFECT OF MCT MILK AND OIL TREATMENT FOR PYRUVATE

DEHYDROGENASE COMPLEX DEFICIENCY Kazutoshi Nakano1,2, 1. Nakano Children’s Clinic, Saitama 356-0004, Japan 2. Department of Pediatrics, Tokyo Women’s Medical University, Tokyo 162-8666, Japan

(IL-22) COMPREHENSIVE MITOCHONDRIAL HAPLOGROUP ANALYSIS SYSTEM BASED

ON SUSPENSION-ARRAY TECHNOLOGY USING DNA FROM FORMALIN-FIXED PARAFFIN-EMBEDDED AUTOPSY TISSUES

Yutaka Nishigaki Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi, Tokyo 173-0015, Japan.


10:10 – 11:50 Invited Lectures Session 7 Chairperson: Roland Stocker (University of Sydney, Australia)

Makoto Suematsu (Keio University, Japan) (IL-23) BIOLOGICAL FUNCTIONS OF HEME OXYGENASE-1: A NOVEL LINK TO

MITOCHONDRIAL FUNCTION? Roland Stocker Centre for Vascular Research, School of Medical Sciences (Pathology) and Bosch Institute, Sydney Medical School, the University of Sydney, Sydney NSW 2006 Australia.

(IL-24) ROLE OF MITOCHONDRIAL UBIQUITIN LIGASE MITOL IN MITOCHONDRIAL

FUNCTION Shigeru Yanagi Laboratory of Molecular Biochemistry, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.

(IL-25) Exploration of pathological properties of cancer stem cells (CSCs): analysis of CSC-specific

mitochondrial protein and heat shock protein Toshihiko Torigoe, Yoshihiko Hirohashi, Akari Takahashi, Satoshi Nishizawa, Yasuaki Tamura, Noriyuki Sato Department of Pathology, Sapporo Medical University School of Medicine Sapporo 060-8556, Japan.

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(IL-26) CO-mediated regulation of remethylation and transsulfuration pathways: Impact through regulating macromolecular methylation and H2S Makoto Suematsu Department of Biochemistry, School of Medicine, Keio University, JST ERATO Suematsu Gas Biology Project*, Tokyo 160-8582, JAPAN

(IL-27) ROLE OF HIGH-DENSITY LIPOPROTEIN IN LIPID HYDROPEROXIDE ELIMINATION

FROM OXIDIZED LOW-DENSITY LIPOPROTEIN Junji Terao Department of Food Science, Graduate School of Nutrition and Bioscience, Institute of Health Biosciences, the University of Tokushima, Tokushima 770-8503, Japan.


(Sponsored by MSD K.K.) Chairperson: Hirohito Tsubouchi (Kagoshima University, Japan) (LS-2) Hepatitis Cand Oxidative Stress

Kazuhiko Koike DepartmentofGastroenterology, GraduateSchoolofMedicine, The University of Tokyo, Tokyo l13-8655, Japan. DirectorGeneral, TheJapanSocietyofHepatology（JSH）

14:30 – 15:30 Special Lectures Coorganized by Japanese Society of Anti-Aging Medicine

Chairperson: Toshikazu Yoshikawa (Kyoto Prefectural University of Medicine, Japan) (SL -1) EFFICACY OF VITAMIN E FOR NONALCOHOLIC STEATOHEPATITIS (NASH)

Yuji Naito1, Yoshio Sumida1,2, and Toshikazu Yoshikawa1 1Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan 2Center for Digestive and Liver Diseases, Nara City Hospital, Nara, Japan

(SL-2) MICRO RNA SIGNATURES OF LONGEVITY WITH RESVERATROL AND TOCOTRIENOL IN HEART MITOCHONDRIA

Partha Mukhopadhyay, Somak Das and Dipak K. Das Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, CT 06030-1110, USA

(SL-3) DIFFERENTIAL IMMUNOMODULATORY AND ANTITUMOR ACTIVITIES OF

TOCOTRIENOLS: POSSIBLE MECHANISMS C.V. Wilankar, S.K. Sandur and T.P.A. Devasagayam Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai – 400 085, India

15:30 – 15:50 Coffee Break 15:50 – 17:30 Invited Lectures Session 8 Chairperson: Norbert A. Dencher (Organische Chemie und Biochemie, Germany)

Shinya Toyokuni (Nagoya University, Japan) (IL-28) ROLE OF IRON IN ASBESTOS-INDUCED MESOTHELIAL CARCINOGENESIS AND ITS

PREVENTION STRATEGY Shinya Toyokuni Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya 466-8550, Japan.

(IL-29) IMPACT OF IONIZING RADIATION AND SENESCENCE ON ROS LEVEL,

MITOPROTEOME AND ENERGY DEMAND OF HUMAN CELLS Norbert A. Dencher1, Zahnreich S.2, Fournier C. 2, Ritter S. 2, Frenzel M.1 1Physical Biochemistry, Dept. Chemistry, Technische Universitaet Darmstadt, Petersenstraße 22, D-64287 Darmstadt, Germany 2Gesellschaft für Schwerionenforschung (GSI), Darmstadt, Germany

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(IL-30) 8-OXOGUANINE, A SPONTANEOUSLY OXIDIZED GUANINE BASE, PROMOTES SOMATIC AND MEIOTIC RECOMBINATION, THUS CONTRIBUTING TO CARCINOGENESIS AND GENOMIC DIVERSITY

Yusaku Nakabeppu Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan

(IL-31) GLUCOSE AND CELL-CYCLE REGULATE COMPLEX-I ACTIVITY IN RESPONSE TO

DRUG-INDUCED MITOCHONDRIAL DYSFUNCTIONS Giuseppe Cannino1, Riyad El-Khoury2, Marja Pirinen1, Bettina Hutz1, Pierre Rustin2, Howard T. Jacobs1, Eric Dufour1* 1Institute of Medical Technology and Centre for Laboratory Medicine, Tampere University Hospital, FI-33014 University of Tampere, Finland 2INSERM U676 and Université Paris 7, Faculté de Médecine Denis Diderot, Paris, France

(IL-32) A novel protein degradation system in young onset Parkinson’s disease: Mitophagy is a therapeutic target as a quality control for damaged mitochondria

Nobutaka Hattori Department of Neurology, Juntendo University School of Medicine, Tokyo 113-8421, Japan.

17:30 – 18:30 ASMRM-Asia Business Meeting (The 1st meeting room)

< THE CITIZEN’S HALL>


(Sponsored by Fuji Chemical Industry Co., Ltd.) Chairperson: Junji Terao (The University of Tokushima) (LS-3) ASTAXANTHIN IS ANTI-INFLAMMATORY AND ANTI-AN GIOGENIC IN PREVENTING

AGE-RELATED MACULAR DEGENERATION Susumu Ishida Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan.

(LS-4) THE TARGET OF ASTAXANTHIN IS MITOCHONDRIA

Yuji Naito

Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.

13:30 – 14:30 Poster Presentation

14:30 – 15:30 Young Investigator Awards Presentation Session 3

Chairperson: Yutaka Nishigaki (Metropolitan Geriatric Hospital and Institute of Gerontology, Japan) (YI-11) REMOVAL OF PREDICTED MITOCONDRIAL TARGETING SIGNAL OF HUMAN COQ5

PROTEIN FACILITATES PROTEIN PURIFICATION FOR ANTIBODY PRODUCTION Shih-Wei Chen1,2) and Hsiu-Chuan Yen1) 1)Graduate Institute of Medical Biotechnology and Laboratory Science and 2)Graduate Institute of Biomedical Sciences, Chang Gung University, Kwei-Shan, Tao-Yuan 333, Taiwan.

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(YI-12) EFFECT OF MITOCHONDRIAL O2•- INDUCIBLE COMPLEX II MUTATION ON FERTILITY AND DELIVERY IN MEV-1 MOUSE MODEL Takamasa Ishii1), Masaki Miyazawa1), Philip S. Hartman2), and Naoaki Ishii1) 1)Department of Molecular Life Science, Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan 2)Department of Biology, Texas Christian University, Fort Worth, TX 76129, USA.

(YI-13) Non-toxic concentration of ASA induced ROS production and increase of small intestinal epithelial cell permeability.

Akifumi Fukui, Yuji Naito, Osamu Handa, Kazuhiro Kamata, Kazuhiro Katada, Kazuhiko Uchiyama, Tsuyoshi Ishikawa, Tomohisa Takagi, Nobuaki Yagi, Satoshi Kokura, Toshikazu Yoshikawa Department of Gastroenterology and Hepatology, Kyoto Prefectural Univ. of Medicine, Kyoto, Japan, 602-8566

(YI-14) Synthesis and structure-reactivity relationship of 2,6-substituted piperidine nitroxide Toshihide Yamasaki1), Fumiya Mito1), Yuichi Kinoshita1), Yuko Ito1), Kana Kitagawa1), Yuta Matsuoka1), Sokkar Pandian2), Ramachandran Murugesan2,3), Mayumi Yamato4), Kiyoshi Sakai4), Hideo Utsumi4), and Ken-ichi Yamada1) 1)Department of Bio-functional Science, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. 2)School of Chemistry, Madurai Kamaraj University, Madurai-625021, India. 3)Networking Resource Center in Biological Sciences, Madurai Kamaraj University, Madurai-625021, India. 4)Innovation Center for Medical Redox Navigation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

(YI-15) ULCERATIVE COLITIS TREATMENT BY NITROXIDE RADICAL-CONTAINING

NANOPARTICLE Toru Yoshitomi1, Long Binh Vong 1, Hirofumi Matsui2, Yukio Nagasaki1-3 1)Graduate School of Pure and Applied Sciences, University of Tsukuba 2)Graduate School of Comprehensive Human Sciences, University of Tsukuba 3)Satellite Laboratory of International Center for Materials Nanoarchitechtonics, National Institute of Materials Science (NIMS), University of Tsukuba, Ten-noudai 1-1-1, Tsukuba, Ibaraki 305-8573, Japan.

15:30 – 15:45 Coffee Break 15:45 – 16:33 Young Investigator Awards Presentation Session 4 Chairperson: Osamu Handa (Kyoto Prefectural University of Medicine, Japan) (YI-16) HYPERPERFUSION IN “PRE-STROKE” LESIONS OF MELAS DETECTED BY

NON-CONTRAST MEDIA PERFUSION MR IMAGING Tomoko Muramatsu1), Masamichi Ikawa1), Tomoko Takeda1), Tatsuya Yamamoto2), Nobuyuki Kosaka2), Kazuyuki Kinoshita2), Yasunari Nakamoto1), Hirohiko Kimura2), and Makoto Yoneda1) 1) Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan. 2) Department of Radiology, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan.

(YI-17) MIR-885-5P, A P53-ACTIVATED MICRORNA, REGULATES WNT/b�CATENIN

SIGNALING PATHWAY AND HEPATOCELLULAR CARCINOMA METASTASIS Zhuhong Zhang1,2), Pengjun Zhang1), Jing Yin2), Si Chen2), Antao Chang2), Lina Wang2), Ze Liu2), Chunyan Zhang1, 2), Nan Bai2), Ze Liu2), Chenghu Liu2), Dan Lv2), Yanhua Liu2), Rong Xiang2)* and Yaping Tian1)*

1) Department of Clinical Biochemistry, Chinese PLA General Hospital, Beijing, 100853, China. 2) Department of Immunology; The school of Medicine, Nankai University, Tianjin, 300071, China.

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(YI-18) Whole-body kinetic image of a redox probe in mice using Overhauser-enhanced MRI Nuttavut Kosem1), Kazuhiro Ichikawa1), Noppawan Phumala Morales2), Ken-ichi Yamada3), Keiji Yasukawa1,3), Fuminori Hyodo1), Tatsuya Naganuma4), Hideo Utsumi1) 1)Innovation Center for Medical Redox Navigation, Kyushu University, Fukuoka 812-8582, Japan 2)Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand 3)Department of Bio-Functional Science, Faculty of Pharmaceutical Science, Kyushu University, Fukuoka 812-8582, Japan 4)Department of Development, Japan REDOX Ltd., Fukuoka 812-0044, Japan

(YI-19) NITROXIDES PREVENT EXACERBATION OF INDOMETHACIN-INDUCED GASTRIC

DAMAGE IN ADJUVANT ARTHRITIS RATS Keiji Yasukawa1, 2), Hisato Deguchi1), Toshihide Yamasaki1), Fumiya Mito1), Yuichi Kinoshita1), Tatsuya Naganuma1, 3), Suguru Sato1), Mayumi Yamato2), Kazuhiro Ichikawa2), Kiyoshi Sakai2), Hideo Utsumi2), and Ken-ichi Yamada1) 1)Department of Bio-functional Science, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan. 2)Innovation Center for Medical Redox Navigation, Kyushu University, Fukuoka 812-8582, Japan. 3)Japan Redox Limited, Fukuoka 812-0044, Japan.

17:30 – 18:30 SFRR-Asia Business Meeting (The 2nd meeting room)

18:30 – 20:30 Lecture for Citizen (The First Hall)

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Saturday, September 3rd

< THE SECOND HALL>

8:30 – 9:50 Invited Lectures Session 9 Chairperson: Valerian E. Kagan (University of Pittsburgh, USA)

Masashi Tanaka (Tokyo Metropolitan Institute of Gerontology, TMIG, Japan) (IL-33) CONSTRUCTIVE FREE RADICAL PESSIMISM: MITOCHONDRIAL TARGETING OF

REDOX REGULATORS Valerian Kagan Center for Free Radical and Antioxidant Health, and Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219

(IL-34) IFREE RADICAL OXIDATION OF CARDIOLIPIN: CHEMICAL MECHANISM, ANALYSIS, AND BIOLOGICAL IMPLICATIONS

Huiyong Yin Departments of Medicine, Pharmacology, and Chemistry, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Vanderbilt University, Nashville, TN 37232, USA.

(IL-35) MELAS AND L-ARGININE THERAPY –FIVE YEARS OUTOCOME

Yasutoshi Koga Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Fukuoka, 830-0011, Japan

(IL-36) REGULATION AND ROLES OF MITOCHONDRIAL DYNAMICS IN MAMMAL

Kenta Onoue, Maki Maeda-Ishihara, Naotada Ishihara Department of Protein Biochemistry, Institute of Life Science, Kurume University, Kurume, Fukuoka, 839-0864, Japan


10:10 – 11:50 Invited Lectures Session 10 Chairperson: Daret K St Clair (University of Kentucky, USA)

Quan Chen (Chinese Academy of Sciences, Nankai University, China) (IL-37) REDOX BALANCE- AND RADIATION-MEDIATED ALTERATIONS IN HIPPOCAMPAL NEUROGENESIS

Ting-Ting Huang Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Geriatric Research, Education, and Clinical Center (GRECC), VA Palo Alto Health Care System, Palo Alto, CA 94304, USA

(IL-38) Design of Mn porphyrins for treatment of oxidative stress diseases Ines Batinic-Haberle

Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA

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(IL-39) Redox signals towards apoptosis Qi Ma1, 3, 7, Huaqiang Fang2, 7, Wei Shang2, Lei Liu1, 3, Zhengshuang Xu4, Tao Ye4, 5, Xianhua Wang2, Ming Zheng2, 8, Quan Chen1, 6, 8 and Heping Cheng2

1Joint Laboratory of Apoptosis and Cancer Biology, National Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. 2Institute of Molecular Medicine and National Laboratory of Biomembrane and Membrane Biotechnology, Peking University, Beijing 100871, China. 3Graduate University of Chinese Academy of Sciences, Beijing 100049, China. 4Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China. 5Department of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China. 6Tianjin Key Laboratory of Protein Sciences, College of Life Sciences, Nankai University, Tianjin 300071, China. 7These authors contributed equally to the work. 8Correspondence should be addressed to M.Z. or Q.C.

(IL-40) MITOCHONDRIAL MEMBRANE POTENTIAL, COUPLING CONTROL, H2O2

PRODUCTION, AND THE UPPER LIMIT OF MITOCHONDRIAL PERFORMANCE Z. Sumbalova, 1 D.K. Harrison,1 P. Gradl,2 M. Fasching, 1 Erich Gnaiger1,3

MitoCom Tyrol, 1OROBOROS INSTRUMENTS, Innsbruck, Austria; 2WGT-Elektronik, Kolsass, Austria; 3D. Swarovski Research Laboratory (Mitochondrial Physiology), Dept. General, Visceral and Transplant Surgery, Innsbruck Medical University, 6020 Innsbruck, Austria.

(IL-41) 4-hydroxy-2-nonenal mediates retrograde signaling

Daret K. St Clair Graduate Center of Toxicology and Markey Cancer Center University of Kentucky College of Medicine Lexington, Kentucky 40506, USA


(Sponsored by Summit Pharmaceuticals International Corporation) Summit Pharmaceuticals Int’l Corp. ( SPI ) SPI is a ONE STOP SHOP of Bio Imaging Technologies in research market. IVIS from CaliperLS is well known defacto technology for Optical Imaging. Today SPI presents three other new technologies.

12:10 – 13:10 J-mit Business Meeting (The 1st meeting room) 14:30 – 15:30 Invited Lectures Session 11

Chairperson: Yau Huei Wei (Mackay Medical College, Taiwan)

Yasutoshi Koga (Kurume University, Japan) (IL-42) MITOCHONDRIAL DYSFUNCTION-ELICITED OXIDATIVE STRESS CAUSES THE

METABOLIC SHIFT FROM MITOCHONDRIAL RESPIRATION TO GLYCOLYSIS IN HUMAN CELLS HARBORING THE A8344G MUTATION OF MITOCHONDRIAL DNA

Yau-Huei Wei1, 2), Shi-Bei Wu1), Yi-Shing Ma1), Yu-Ting Wu1), Yin-Chiu Chen1) and Wan-Yu Lee1)

1)Department of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei, Taiwan. 2) Department of Medicine, Mackay Medical College, New Taipei City, Taiwan

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(IL-43) Diagnosis and molecular basis of mitochondrial respiratory chain disorders in Japan: the use of next generation sequencing technology

Akira Ohtake1), Kei Murayama2), Masato Mori3), Yasushi Okazaki4) 1)Department of Pediatrics, Faculty of Medicine, 4)Research Center for Genomic Medicine, Saitama Medical University, Saitama 350-0495, Japan, 2)Department of Metabolism, Chiba Children's Hospital, Chiba 266-0007, Japan, 3)Department of Pediatrics, Jichi Medical University, Tochigi 329-0498, Japan

(IL-44) Similar expression of clinical phenotype and tissue heteroplasmy of mitochondrial 3243A>G

mutation in monozygotic twins: a report of two families Kengo Maeda1,2), Hiromichi Kawai2), Mitsuru Sanada2), Tomoya Terashima2), Nobuhiro Ogawa1,2), Kazuhiro Ikeda2), Yasushi Omura2), Akihiko Shiino3), Hitoshi Yasuda2), Shun-ichi Sato4), Ken-ichi Hoshi4), Hiroyuki Yahikozawa4), Katsuji Nishi5), Yasushi Itoh6), Kazumasa Ogasawara6), Tetsuya Makiishi7), Kazuo Tomita8), Yoichiro Iwashita8), Hiroko P Indo8), Hideyuki J Majima8)

1)Department of Neurology, National Hospital Organization Shiga Hospital 255 Gochi, Higashi-oumi, Shiga 527-8505, Japan, 2) Division of Neurology and Metabolism and Endocrinology, Department of Internal Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan 3) Department of Neurosurgery, Shiga University of Medical Science, Otsu, Shiga, Japan 4) Department of Neurology, Nagano Red Cross Hospital, Nagano, Japan 5) Department of Legal Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan 6) Division of Pathology and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Shiga, Japan 7) Department of Internal Medicine, Yabase Chuo Hospital, Kusatsu, Shiga, Japan 8) Department of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

15:30 – 15:50 Coffee Break 15:50 – 16:50 Invited Lectures Session 12 Chairperson: Masahiro Higuchi (University of Arkansas for Medical Sciences, USA)

Kimitoshi Sakamoto (Hirosaki University, Japan) (IL-45) Redox mediated protection of prostate cancer: An Insight into the Mechanisms of NF-kB-mediated Carcinogenesis and Radiation Resistance William H. St. Clair Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky, USA. (IL-46) LIVE IMAGING OF ROS, RNS AND IN VIVO TINY TUMORS WITH RATIONALLY DESIGNED FLUORESCENE PROBES Yasuteru Urano Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan, and Basic Research Program, Japan Science and Technology Agency, Tokyo 102-0075, Japan. (IL-47) Mitochondria-generated progression signal of advanced cancer: Roles of mevalonate pathway in prostate cancer progression Masahiro Higuchi*, Cody C. Cook*, Ara Kim*, Shuji Terao#, Akinobu Gotoh# *Department of Biochemistry and Molecular Biology University of Arkansas for Medical Sciences #Laboratory of Cell and Gene Therapy, Institute for Advanced Medical Sciences, Hyogo College of Medicine 16:50 – 17:10 Coffee Break

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17:10 – 18:30 Invited Lectures Session 13 Chairperson: Jiankang Liu (Xi'an Jiaotong University, China)

Kanthimathi Subramaniam (University of Malaya, Malaya) (IL-48) FLAVONOIDS SUPPRESS NICOTINE-INDUCED CARCINOGENICITY AND

GENOTOXICITY M.S.Kanthimathi Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia

(IL-49) HYDROXYTYTROSOL: A RISING STAR OF NUTRACEUTICAL AFTER RESVERATROL AS AN ANTIOXIDANT AND MITOCHONDRIAL TARGETING NUTRIENT

Jiankang Liu The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Mitochondrial Biology and Medicine, Xi’an Jiaotong University School of Life Science and Technology, Xi’an, China

(IL-50) A PROMISING MITOCAN FROM AN INDIAN SPICE Subrata Chattopadhyay

Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai - 400085, India.

(IL-51) ARE THE PHENOLIC GROUPS ESSENTIAL FOR ANTIOXIDANT ACTION?

S. Adhikari Radiation and Photochemistry Division, Bhabha Atomic Research Centre Mumbai – 400085, India

< THE CITIZEN’S HALL> 13:30 – 14:30 Poster Presentation

14:30 – 15:50 CoQ Session Chairperson: Yorihiro Yamamoto (Tokyo University of Technology, Japan)

(CS-1) ROLES OF COENZYME Q IN ELECTRON TRANSPORT, OXIDATIVE STRESS, URACIL METABOLIASM AND SULFIDE OXIDATION IN MITOCHONDIRA Makoto Kawamukai Faculty of Life and Environmental Science, Shimane University, Shimane 690-8504, Japan.

(CS-2) IMPAIRED TISSUE HOMEOSTASIS AND REGENERATION BY SILENCING D-LESS POLYPRENYL DIPHOSPHATE SYNTHASE GENE EXPRESSION IN PLANARIAN

Tomoyasu Sugiyama Tokyo University of Technology, School of Bioscience and Biotechnology, Tokyo 192-0982, Japan.

(CS-3) The role of CoQ10 binding and transfer protein Yorihiro Yamamoto Tokyo University of Technology, School of Bioscience and Biotechnology, Tokyo 192-0982, Japan.

(CS-4) PATHOGENESIS AND MANAGEMENT OF SJOGREN’S SYNDROME - Effects of Coenzyme Q10 on Salivary Secretion-

Ichiro Saito Department of Pathology, Tsurumi University School of Dental Medicine, Yokohama 230-8501, Japan.

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16:30 – 17:18 Young Investigator Awards Presentation Session 5 Chairperson: Naotada Ishihara (Kurume University, Japan) (YI-20) ATF4 IS DIRECTLY RECRUITED BY TLR4 SIGNALING AND

POSITIVELY REGULAYES TLR-TRIGGED CYTOKINE PRODUCTION Chunyan Zhang1）

，Nanbai1）

，Zhuhong Zhang1）, Antao Chang1）

，Rong Xiang1）

，Chenghu Liu1） 1）Department of Immunology, Nankai University School of Medicine,

tianjin, China (YI-21) Palmatine an anti-obese and anti-diabetic molecule but a weak antioxidant M.K.Sangeetha1）, A. Hannah Rachel Vasanthi2）

1）Senior Research Fellow, Herbal and Indian Medicine Research Lab, Biomedical Research Cell, Sri Ramachandra University, Chennai- 600116, India. 2）Associate Professor, Department of Biotechnology, School of Life Sciences, Pondicherry University, Puducherry 605 014, India.

(YI-22) Monitoring the amyloid β aggregation and free radical reaction using spin-labeled, profluorescent nitroxide Fumiya Mito1）, Toshihide Yamasaki1）, Yuko Ito1）, Mayumi Yamato2）, Hiroyuki Mino3）, Hiromi Sadasue1）, Chisato Shirahama1）, Kiyoshi Sakai2）, Hideo Utsumi2）, and Ken-ichi Yamada1）

1）Department of Bio-functional Science, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi Higashiku Fukuoka, 812-8582, Japan.,

2）Innovation Center for Medical Redox Navigation, Kyushu University, 3-1-1 Maidashi Higashiku Fukuoka, 812-8582, Japan., 3）Graduate School of Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan.

(YI-23) EFFECT OF NUCLEAR MITOCHONDRIAL DNA SEQUENCES ON DETECTING HUMAN mtDNA MUTATIONS BY DENATURING HPLC AND SURVEYOR NUCLEASE Shiue-Li Li, Wei-Chien Hsu, Hsiu-Chuan Yen Graduate Institute of Medical Biotechnology and Laboratory Science, Chang

Gung University, Kwei-Shan, Tao-Yuan 333, Taiwan.

17:18 – 17:30 Coffee Break 17:30 – 18:06 Young Investigator Awards Presentation Session 6

Chairperson: Hirofumi Matsui (University of Tsukuba, Japan) (YI-24) DETECTION AND FUNCTIONAL ANALYSES OF microRNA IN HIGH-GRADE PHENOTYPE OF IRON SACCHARATE-INDUCED MESOTHELIOMA IN RATS. Yasumasa Okazaki1）, Hu Qian1）, Shinya Akatsuka1）, Kyoko Yamashita1）, Satomi Funahashi1）, Yoriko Yamashita1）, Li Jiang1）, Hiroki Ohara1）, Chew Shan Hwu1）, Hirotaka Nagai1）, Takashi Takahashi2）, Shinya Toyokuni1）

1）Nagoya University Graduate School of Medicine, Department of Pathology and Biological Response, Nagoya, 466-8550, Japan. 2）Nagoya University Graduate School of Medicine, Department of Molecular Carcinogenesis, Nagoya, 466-8550, Japan.

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(YI-25) Resveratrol Impedes the EMT, Stemness, and Metabolic Reprogramming of Cancer Stem Cells by Inducing miRNAs in Nasopharyngeal Carcinoma through p53 Activation Yao-An Shen, 1 Yann-Chang Chen2, and Yau-Huei Wei1, 3 1Institute of Biochemistry and Molecular Biology, 2Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan 112 3Department of Medicine, Mackay Medical College, San-Jhih, New Taipei City, Taiwan 252

(YI-26) A PROPOSED MECHANISM BY WHICH OXIDATIVE STRESS IS INDUCED BY HUMAN IMMUNODEFICIENCY VIRUS-1 (HIV-1) TAT: CELLULAR HEME ACCUMULATION Marni E. Cueno, Kenichi Imai and Kuniyasu Ochiai Department of Microbiology, Nihon University School of Dentistry, Tokyo 101-8310, Japan.

19:00 – 21:00 Banquet (Sun Royal Hotel)

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Sunday, September 4th

< THE SECOND HALL>

8:30 – 9:50 Invited Lectures Session 14 Chairperson: Albert Sanz (University of Tampere, Finland)

Michiru D. Sugawa (Universitätsmedizin Berlin, Germany) (IL-52) Comparative bioenergetical study of neuronal and muscle mitochondrial DNA during aging Hong-Zhi Li, Youfen Li and Yidong Bai

School of Life Science, Wenzhou Medical College, Wenzhou 325035, China; Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229

(IL-53) MITOCHONDRIAL COMPLEX I AS A MASTER REGULATOR OF DAMAGE GENERATION AND LONGEVITY

Alberto Sanz Mitochondrial Gerontology and Age-Related Diseases Group, Institute of Biomedical Technology and Tampere University Hospital, University of Tampere, FI-33520 Tampere, Finland

(IL-54) MITOCHONDRIA, THE GREAT PERFORMER IN HIPPOCAMPAL AGEING

Michiru D. Sugawa1,2, Hans Rommelspacher1, Regina Hill1, Monika Frenzel2

1Department of Psychiatry, Charité – Universitaetsmedizin Berlin, D-14050 Berlin, Germany;

2Physical Biochemistry, Department Chemistry, Technische Universitaet Darmstadt, D-64287 Darmstadt, Germany (IL-55) EXOME ANALYSIS OF SENESCENCE-ACCELERATED MICE

Masashi Tanaka1, Kumpei Tanisawa1,2, Eri Mikami1,2, Noriyuki Fuku1, Ikuroh Ohsawa1, Kinji Ohno3 1Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Itabashi, Tokyo 173-0015, Japan, 2Graduate School of Sport Science, Waseda University, 3Department of Neurogenetics, Nagoya University Graduate School of Medicine


10:10 – 12:10 Invited Lectures Session 15 Chairperson: Shigeo Ohta (Nippon Medical School, Japan)

Hirotaka Imai (Kitasato University, Japan) (IL-56) RECENT DEVELOPMENT TOWARD THE HYDROGEN MEDICINE: POTENTIAL FOR PREVENTIVE AND THERAPEUTIC APPLICATIONS AND A POSSIBLE MECHAMISM TO EXHIBIT ITS BENEFITS

Shigeo Ohta Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Kawasaki 211-8533 Japan,

(IL-57) THE ROLE OF MITOCONDRIAL AND NON-MITOCHON DRIAL PHGPX IN SPERMATOGENESIS AND SPERM FUNCTION IN MICE

Hirotaka Imai School of Pharmaceutical Sciences, Kitasato University,

5-9-1 Shirokane Minato-ku, Tokyo 108-8641, Japan.

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(IL-58) MITOCHONDRIA REDUCE THE PRODUCTION OF ROS BY THEIR TRANSIENT DEPOLARIZATIONS

Yoshihiro Ohta, and Takumi Onojima Division of Biotechnology and Life Sciences, Institute of Engineering,

Graduate School of Tokyo University of Agriculture and Technology, Tokyo 184-8588, Japan



Chairperson: Christopher G Kevil (Louisiana State University, USA) Shazib Pervaiz (Duke-NUS Graduate Medical School, Singapore)

(IL-59) CHRONIC EXERCISE TRAINING MEDIATE INSULIN RESISTANCE IN MUSCLE: ADAPTATION OF MITOCHONDRIAL DYNAMICS

Fei Zhao, Yong Zhang Mitochondrial Physiology Group, Tianjin Key Laboratory of Exercise Physiology and Sports

Medicine. Department of Health and Exercise Sciences, Tianjin University of Sport, Tianjin 300381, China

(IL-60) Hydrogen sulfide-NO crosstalk: ischemic tissue cytoprotection and mitochondria.

Christopher G Kevil Department of Pathology LSU Health Sciences Center Shreveport, Louisiana, USA.

(IL-61) REDOX-DEPENDENT CELL FATE SIGNALING IN CANCER CELLS Shazib Pervaiz Department of Physiology, Yong Loo Lin School of Medicine and CSCB Program, Duke-NUS Graduate Medical School, Singapore

12:30 – 12:40 Closing Remarks

< THE CITIZEN’S HALL>

11:00 – 14:00 Dr.Goto-Group meeting (meeting Room) Meeting for patientsof Mitochondrial Disease and Their Family

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Poster Presentations (P-1)

MATHEMATICAL MODELING OF THE APOPTOTIC PATHWAYS IND UCED BY CISPLATIN Ji-Young Hong1), Soon-Sung Kwon1), Kenjirou Hara2), Eisuke Sato3), Eun-Bo Shim1)

1)Department of Mechanical & Biomedical Engineering, Kangwon National University, Korea. 2)Iwata Chemical CO., LTD, 3069 Nakaizumi, Iwata, Shizuoka 438-0078, Japan. 3)Department of Medical Biochemistry, Suzuka University of Medical Science, Japan. Email: [email protected]


THE ROLE OF IRON ACCUMULATION ON HCV CORE PROTEIN INDUCED-MITOCHONDRIAL DAMAGE Shuichi Sekine1), Konomi Ito1), Kazuhiko Koike2), Kyoji Moriya2), Yoshizumi Shintani2), Hajime Fujie2), Takeya Tsutsumi2), Hideyuki Miyoshi2), Hidetake Fujinaga2), Yasuko Niizawa2), and Toshiharu Horie1)

1)Department of Biopharmaceutics, Graduate School of Parmaceutical Sciences, Chiba University, Chiba, Japan. 2) Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan E-mail: [email protected]


EFFECTS OF INDOMETHACIN ON RAT GACTRIC NORMAL CELLS RGM-1 AND ITS TUMORIZED CELLS RGK-1 AND THE PREVENTION BY REBAMIP IDE Motoharu Miyamoto1), Hiroko P. Indo2), Kazuyuki Noguchi1), Hciu-Chuan Yen3), Hirofumi Matsui4), Toshihiko Ozawa5) and Hideyuki J. Majima2,6) 1),Division of Periodontology, 2)Department of Oncology, 6)Department of Space Environmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan 3)Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Kwei-Shan, Tao-Yuan 333, Taiwan 4)Division of Gastroenterology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan. 5Department of Health Pharmacy, Yokohama College of Pharmacy, Totsuka, Kanagawa 245-0066, Japan


DISRUPTION OF NEUROVASCULAR UNIT RELATING TO OXIDAT IVE STRESS AND MITOCHONDRIAL DEFICIT PRIOR TO MOTOR NEURON DEGENER ATION IN ALS Kazunori Miyazaki, Yasuyuki Ohta, Nobutoshi Morimoto, Tomoko Kurata, Yoshio Ikeda, Tohru Matsuura, Koji Abe Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and pharmaceutical science E-mail: [email protected]

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IRON INDUCED OXIDATIVE STRESS INTERACTS WITH VIRAL REPLICATION IN FULL GENOMIC HEPATITIS C VIRUS REPLICON CELLS Masaaki Korenaga1), Masanori Ikeda2), Nobuyuki Kato2), and Keisuke Hino1)

1)Department of Hepatology and Pancreatology, Kawasaki Medical College, Kurashiki, Okayama 7010192, Japan. 2) Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, 700-8558, Japan. E-mail: [email protected]


ANALYSIS OF NOVEL HYPOXIC MITOCHONDRIAL ELECTRON TR ANSPORT CHAIN, NADH-FUMARATE REDUCTASE SYSTEM, AND QUINONE BIOSYNT HESIS IN TUMOR MICROENVIRONMENT Eriko Tomitsuka 1), Kiyoshi Kita 2), Hiroyasu Esumi 1) 1) Cancer Physiology Project, Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan 2) Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan E-mail:[email protected]


MITOCHONDRIAL FUNCTION OF AAA+ PROTEIN CLPX AS A MI TOCHONDRIAL NUCLEOID FACTOR Katsumi Kasashima, Megumi Sumitani, and Hitoshi Endo Department of Biochemistry, Jichi Medical University, Tochigi 329-0498, Japan E-mail: [email protected]


ROLES OF PEROXIREDOXIN 4 IN PROTEIN SULFHYDRYL OXID ATION Toshihiro Kurahashi1), Chihiro Awada2), Tasuku Konno1), Noriyuki Otsuki1), Satoshi Tsunoda1), Xuhong Zhang1), Junitsu Ito1), Yoshihiro Iuchi3), Toshifumi Takao2) and Junichi Fujii1)

1) Graduate School of Medical Science, Yamagata University, Yamagata 990-9585, Japan. 2) Institute for Protein Research, Osaka University, Suita 567-0871, Japan 3) Faculty of Agriculture, Yamaguchi University, Yamaguchi 753-8515, Japan E-mail: [email protected]

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GLUCOSE 6-PHOSPHATE DEHYDROGENASE (G6PD) MODULATES CELLULAR INFLAMMATORY RESPONSE, INNATE IMMUNITY AND XENOBIOT IC METABOLISM Yi-Hsuan Wu1#, Hung-Chi Yang1#, Shin-Ru Lin1#, Mei-Ling Cheng1, 2, Hung-Yao Ho1, and Daniel Tsun-Yee Chiu1, 2* (*Corresponding author; # these authors made equal contribution to this work) 1Department of Medical Biotechnology and Laboratory Sciences, Chang-Gung University, Kwei-Shan, Tao-Yuan 333, Taiwan 2Department of Medical Research and Development, Chang-Gung Memorial Hospital, Kwei-Shan, Tao-Yuan 333, Taiwan


PHOTOCONTROLLABLE NITRIC OXIDE AND PEROXYNITRITE DO NORS FOR SPATIOTEMPORAL CONTROL OF RNS TREATMENT Hidehiko Nakagawa1,6), Kazuhiro Hishikawa1), Naoya Ieda1), Taeko Horinouchi1), Kei Eto2), Junichi Nabekura2), Tao Peng3), Dan Yang3), Kiyoshi Fukuhara4), Toshiaki Furuta5), Takayoshi Suzuki1), and Naoki Miyata1,4)

1)Department of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, Naogya 467-8603, Japan. 2) Division of Homeostatic Development, National Institute of Physiological Sceinces, Okazaki, 444-8585, Japan. 3)Department of Chemistry, The University of Hong Kong, Hong Kong. 4)Division of Organic Chemistry, National Institute of Health Sciences, Tokyo 158-8501, Japan. 5)Department of Biomolecular Science, Toho University, Chiba, 274-8510 Japan. 6)PRESTO, Japan Science and Technology Agency (JST), Saitama 322-0012, Japan. E-mail: [email protected]


MITOCHONDRIAL DISEASE WITH UNUSUAL EXOCRINE PANCREA TIC MANIFESTATIONS Akihiko Ishiyama1), Hirofumi Komaki1), Takashi Saito1), Yoshiaki Saito1), Eiji Nakagawa1), Kenji Sugai1), Masayuki Sasaki1), Ichizo Nishino2), Yu-ichi Goto1)3) 1) Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan. 2) Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan. 3) Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan. E-mail: [email protected]

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MORPHOLOGICAL AND CHRONOLOGICAL CHANGES OF MITOCHON DRIA IN CAPILLARY ENDOTHELIAL CELLS OF MUSCLES AND CELLS CO MPRISING THE BBB IN MELAS: NEUROPROTECTIVE RESPONSES TO CHRONIC LACTIC ACIDOSIS Mihoko Matsuzaki1&2, Rieko Takahashi1, Kenta Uto3, Hideaki Oda3 & Makiko Osawa1

Departments of Pediatrics1 & Pathology3, Tokyo Women’s Medical University & Nakagawa-no-sato Rehabilitation, Hospital for the Disabled2


UREMIC TOXINS DIRECTLY INCREASED SUPEROXIDE FROM IS OLATED MITOCHONDRIA Aki Hirayama1), Hirofumi Matsui2), Yumiko Nagano2), Atsushi Ueda3), Kazumasa Aoyagi1), Shigeru Owada4) 1) Center for Integrative Medicine, Tsukuba University of Technology, Tsukuba, Japan. 2) Graduate School for Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan. 3) Department of Internal Medicine, Namegata District General Hospital, Namegata, Japan. 4) Dialysis Center, Asao Clinic, Kawasaki, Japan. E-mail: [email protected]


TECHNICAL APPLICATION OF HYDRODYNAMIC LIMB VEIN INJ ECTION FOR IN VIVO MITOCHONDRIAL GENE DELIVERY Yukari Yasuzaki1), Yuma Yamada1), Tsutomu Kanefuji2), Dexi Liu2), and Hideyoshi Harashima1)

1)Laboratory for molecular design of pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 0600812, Japan. 2)Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, 527 Salk Hall, Pittsburgh, Pennsylvania 15261, USA. E-mail: [email protected]


MELAS PHENOTYPE ASSOCIATED WITH THE m.3302A>G MUTAT ION IN THE MITOCHONDRIAL tRNA Leu(UUR) GENE Masahide Goto1), Hirofumi Komaki1), Takashi Saito1), Yoshiaki Saito1), Eiji Nakagawa1), Kenji Sugai1), Masayuki Sasaki1), Ichizo Nishino2), and Yu-ichi Goto1)3) 1) Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan. 2) Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan. 3) Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan. E-mail : [email protected]

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TRANSGENIC MICE EXPRESSING THE REDOX-SENSITIVE GREE N FLUORESCENT PROTEIN Kiyomi Nishimaki, Alexander M Wolf , Takashi Yokota, Naomi Kamimura, Shigeo Ohta Institute of Development and Aging Sciences, Nippon Medical School, Kawasaki 211-8533Japan. E-mail:[email protected]


IN VIVO MEASUREMENTS OF SKIN OXIDATIVE STRESS USING MICE EXPRESSING REDOX-SENSITIVE GFP Alexander M Wolf, Kiyomi Nishimaki, Naomi Kamimura, Shigeo Ohta Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Kawasaki 211-8533, Japan E-mail: [email protected]


NON-INVASIVE MEASUREMENT OF THE REDOX STATUS IN THE MOUSE WHOLE BODY BY IN VIVO EPR SPECTROSCOPY USING ACYL-PROTECTED HYDROXYLAMIN E PROBES Shoko Okazaki, Yoko Tachibana, Keizo Takeshita

Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, Japan. E-mail: [email protected]


MOLECULAR HYDROGEN UPREGULATES HEPATIC MITOCHONDRIA L LIPID METABOLISM-RELATED GENES, REDUCES OXIDATIVE STRESS, IMPROVES OBESITY IN TYPE2 DEABETES MODEL MICE Naomi Kamimura 1), Kiyomi Nishimaki 1), Harumi Ichimiya 1),Ikuroh Ohsawa 1, 2), Shigeo Ohta 1) 1)Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Kanagawa 211-8533, Japan 2)Department of Environmental Gerontology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan E-mail: [email protected]

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CYTOCHROME C OXIDASE SUBUNIT 7A RELATED POLYPEPTIDE COX7RP IS AN ESTROGEN TARGET GENE THAT PLAYS A ROLE IN THE OXPHO S PATHWAY Kazuhiro Ikeda1), Kuniko Horie-Inoue1), Satoshi Inoue1,2)

1)Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama 350-1241, Japan. 2)Departments of Anti-Aging Medicine and Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan


PROLONGED NITRIC OXIDE TREATMENT INDUCES TAU AGGREG ATION IN SH-SY5Y CELLS Muneaki Takahashia1), Takashi Nonaka2), Masato Hasegawa2), Nobuo Watanabea1), and Takao Araia1)

1) Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan 2) Department of Neuropathology and Cell Biology Tokyo Metropolitan Institute of Medical Science 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan


SCREENING OF PLANT EXTRACTS FOR HUMAN TYROSINASE IN HIBITING EFFECTS USING THE TRANSFORMED HEK293-TYR CELLS AS AN ENZYME SOURCE Mijin KIM 1) and Yong Chool Boo1) 1)Department of Molecular Medicine, CMRI, BK21, Kyungpook National University School of Medicine, Daegu, 700-422, Republic of Korea


MECHANISMS FOR THE DIFFERENTIAL EXPRESSION OF ENDOT HELIAL ARGININOSUCCINATE SYNTHETASE 1 DUE TO ENDOTHELIAL C ELL SENESCENCE AND LAMINAR SHEAR STRESS Gyeong In Mun1) and Yong Chool Boo1) 1)Department of Molecular Medicine, CMRI, BK21, Kyungpook National University School of Medicine, Daegu, 700-422, Republic of Korea

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PROTECTIVE EFFECT OF IM54, A CELL DEATH INHIBITOR, ON MITOCHONDRIAL DYSFUNCTION INDUCED BY OXIDATIVE STRESS Katsuya Iuchi1, 2), Kosuke Dodo1, 2), Yuou Teng1, 2), Tadashi Shimizu2), Yasunori Mori2), and Mikiko Sodeoka1, 2) 1)Sodeoka Live Cell Chemistry Project, ERATO, Japan Science and Technology Agency, 2-1, Hirosawa, Wako, Saitama 351-0198, Japan. 2)RIKEN, Advanced Science Institute (ASI), 2-1, Hirosawa, Wako, Saitama 351-0198, Japan.E-mail: [email protected]


A COMPARATIVE STUDY ON EFFECT OF PRIOR OR POST RADO N INHALATION ON CARBON TETRACHLORIDE INDUCED OXIDATIVE DAMAGE IN SO ME ORGANS OF MOUSE Yuichi Nishiyama1) Takahiro Kataoka1), Junichi Teraoka1), Akihiro Saokda1),2), Keiko Yamato1), Yuu Ishimori2), and Kiyonori Yamaoka1)

1) Graduate School of Health Sciences, Okayama University, Okayama 700-8558, Japan 2) Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency, Okayama 708-0698, Japan E-mail: [email protected] nduced oxidative damage.


THE MECHANISTIC STUDY OF CYTOTOXIXITY INDUCED BY SI N-1 IN PC12 CELLS Tatsumi Okada, Konishi Kanako, Akashi Souichiro, Nakashima Mitsuhiro, Watanabe Nobuo, and Arai Takao Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of

Science, 2641 Yamazaki, Noda, Chiba, Japan.


NEOECHINULIN A CONFERS CYTOPROTECTION AGAINST NITRO SATIVE STERSSES IN PC12 CELLS WHILE PARADOXICICALLY DECREASING GSH CON TENTS Tomoya Nakagawa1), Soichiro Akashi1), Tatsumi Okada1), Kanako Konishi1), Yuki Ogura1), Koji Kuramochi3), Susumu Kobayashi2), Fumio Sugawara1) , Toshifumi Takeuchi, Nobuo Watanabe1) and Takao Arai1) 1) Department of Applied Biological Science, 2) Department of Pharmaceutical Sciences, Tokyo University of Science. 3) Graduate School of Life and Environmental Sciences, Kyoto Prefectural University.

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DECREASING INTRACELLULAR REACTIVE OXYGEN SPECIES IN HIBITED GASTRIC CANCER CELLULAR INVASION Masato Tamura1, Hirofumi Matsui1, Tsuyoshi Kaneko1, Yumiko Nagano1, Osamu Shimokawa1 Ichinosuke Hyodo1, Tsutomu Tomita2, Hisato Sadakata2, Hiroko P. Indo3 and Hideyuki J Majima3. 1Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan. 2Graduate School of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Japan. 3Kagoshima University, Medical and Dental Sciences, Kagoshima, Japan.


AN INNOVATIVE APPROACH FOR MITOCHONDRIAL GENE DELIV ERY: MITOCHONDRIAL DELIVERY OF OLIGO DNA USING MITO-PORT ER, A LIPOSOME-BASED CARRIER FOR MITOCHONDRIAL DELIVERY V IA MEMBRANE FUSION. Eriko Kawamura1), Yuma Yamada1), and Hideyoshi Harashima1)

1)Laboratory for molecular design of pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.


ENERGY METABOLISM ABNORMALITY OF ULTRAVIOLET IRRADI ATION SENSITIVE MUTANT RAD-8 IN C. ELEGANS Kayo Yasuda1), Michihiko Fujii2), Hitoshi Suda3), Phillip Hartman4), Tomoichi Ohkubo1), Naoaki Ishii5) 1) Education and Research Support Center, Tokai University, Isehara, 259-1193, Japan 2) Graduate School of Nanobioscience, Yokohama City University, Yokohama 236-0027, Japan 3) School of High-technology for Human Welfare, Tokai University, Numazu, 410-0395, Japan 4) Department of Biology, Texas Christian University, Fort Worth, Texas 76129, USA 5) Department of Molecular Life Science, Tokai University School of Medicine, Isehara, 259-1193, Japan

E-mail : [email protected]


EFFECT OF DNA PACKAGED WITH TFAM ON TRANSCRIPTION A CTIVATION Ryo Furukawa1), Yuma Yamada1), Yuichi Matsushima2), Yu-ichi Goto2), and Hideyoshi Harashima1)

1)Laboratory for molecular design of pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan. 2)Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8502, Japan.

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PROTECTIVE EFFECT OF POLAPREZINC ON ACETYLSALICYLIC ACID-INDUCED APOPTOSIS OF RAT INTESTINAL EPITHELIAL CELLS – INVO LVEMENT OF HEAT SHOCK PROTEIN 70 AND REACTIVE OXIGEN SPECIES. Osamu Handa, Yuji Naito, Akifumi Fukui, Ying Qin, Yukiko Uehara, Toshifumi Tsuji, Hiroyuki Yoriki, Ryusuke Horie, Kazuhiro Katada, Kazuhiro Kamada, Kazuhiko Uchiyama, Takeshi Ishikawa, Tomohisa Takagi, **Yukiko Minamiyama, Hideyuki Konishi, Nobuaki Yagi, Satoshi Kokura, *Hiroshi Ichikawa, Toshikazu Yoshikawa Molecular Gastroenterology and Hepatology, Kyoto Pref. Univ. of Medicine, Kyoto 602-8566, JAPAN *Graduate School of Life and Medical Sciences, Doshisha Univ., Kyoto, 610-0394, Japan. ** Graduate School of Life and Environmental Sciences, Kyoto Pref. Univ., Kyoto, 606-8522, Japan. E-mail: [email protected]


FENOFIBRATE LOWERS LIPID ACCUMULATION IN MYOTUBES B Y MODULATING PPAR Α/AMPK/FOXO1/ATGL PATHWAY Wei�Lu Chen1,2, Yun�Lin Chen4, Yu�Ming Chiang3, Hsiang�Kuan Wang4, and Horng�Mo Lee1,2,4*

1Graduate Institute of Medical Sciences,2School of Medical Laboratory Sciences and Biotechnology,3School of Respiratory Therapy,College of Medicine, Taipei Medical University, Taipei, Taiwan,4Institute of Pharmaceutical Sciences and Technology, Central Taiwan University of Science and Technology, Taichung, Taiwan. Correspondence: Professor Horng-Mo Lee, Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan. Tel: 886-2-2736-1661 ext. 3316; Fax: 886-2-2732-4510; E-mail: [email protected]


CAVEOLIN-1 TO ALTERNATION OF MITOCHONDRIAL MORPHOLO GY, 8-OHDG, AND LIPID DEPOSITION IN VESSEL AND KIDNEY YH CHEN1,2,4), SL SU1,3,4), CS LIU4), WW LIN5), ML HSIEH6)

1) Laboratory of General, Department of Medical Education and Research, Changhua Christian Hospital, Taiwan. 2) Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taiwan. 3) Division of Endocrinology and Metabolism, Department of Internal Medicine, Changhua Christian Hospital; Taiwan. 4) Laboratory of Vascular & Genome, Department of Medical Education and Research, Changhua Christian Hospital, Taiwan. 5) Division of Cardiovascular Center, Department of Internal Medicine, Taichung Veterans General Hospital Taiwan. 6) Department of Life Science, Tunghai University, Taiwan. E-mail:[email protected]

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IRON CHELATION THERAPY WITH DEFERIPRONE IMPROVES OX IDATIVE STATUS OF RED BLOOD CELLS IN b-THALASSEMIA/HEMOGLOBIN E PATIE NTS Noppawan P Morales1), Paveena Yamanont1), Supot Rodrat1), Totsapol Jirasomprasert1), and Suthat Fucharoen2)

1)Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand. 2)Thalassemia Research Center, Institute of Molecular Bioscience, Mahidol University, Salaya Campus, Nakornpathom, Thailand. E-mail: [email protected]

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CYTOSKELETON ORGANIZATION AND MATRIX METALLOPROTEIN ASE 1 EXPRESSION IN RESCUED MERRF SKIN FIBROBLASTS VIA PEPTIDE-MEDIA TED MITOCHONDRIAL DELIVERY Jui-Chih Chang1), Ko-Hung Liu1), Yau-Huei Wei2), Chin-San Liu1,3)

1)Vascular and Genomic Center, Changhua Christian Hospital, Changhua500, Taiwan. 2)Department of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei112, Taiwan. 3)Department of Neurology, Changhua Christian Hospital, Changhua500, Taiwan. E-mail: [email protected]


FACILITATION OF L-TYPE Ca 2+ CHANNELS BY HYDROGEN PEROXIDE IN GUINEA-PIG VENTRTICULAR MYOCYTES Lei Yang, Jianjun Xu, Etsuko Minobe, Rui Feng, Asako Kameyama, Kazuto Yazawa, and Masaki Kameyama Department of Physiology, Graduate School of Medical & Dental Sciences, Kagoshima University, Kagoshima, Japan.


THE THERAPEUTIC ROLE OF HEME OXYGENASE-1 IN THE IND OMETHACIN-INDUCED INTESTINAL INJURY IN MICE Hiroyuki Yoriki, Yuji Naito, Tomohisa Takagi, Akihito Harusato, Shinya Yamada Takaya Iida, Wataru Fukuda, Yutaka Inada, Toshifumi Tsuji, Munehiro Kugai, Ryusuke Horie, Naohisa Yoshida, Kazuhiko Uchiyama, Osamu Handa, Takeshi Isikawa, Nobuaki Yagi, Satoshi Kokura, Sachiko Minamiyama, Hiroshi Ichikawa, Toshikazu Yosikawa Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan E-mail: [email protected]


IONIZING RADIATION STIMULATES MITOCHONDRIAL ELECTRO N TRANSPORT CHAIN ACTIVITY AND INCREASES MITOCHONDRIAL CONTENT Tohru Yamamori1), Yasui Hironobu1), Masayuki Yamazumi1), Yoshinari Nakamura1), Hideo Nakamura2), Osamu Inanami1)

1)Laboratory of Radiation Biology, Department of Environmental Veterinary Medical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan 2)Department of Humanities and Regional Sciences, Hokkaido University of Education Hakodate, Hakodate 040-8567, Japan E-mail: [email protected]

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TWO TYPES OF LOOP VI STRUCTURE IN COPPER ZINC SUPEROXIDE DISMUTASE Noriko Fujiwara 1), Kentaro Ihara 2), Yoshiki Yamaguchi 3), Hidetaka Torigoe 4), Daisaku Yoshihara 1), Hironobu Eguchi 1), Haruhiko Sakiyama 1), Soichi Wakatsuki 2), Naoyuki Taniguchi 3), Keiichiro Suzuki 1)

1) Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Hyogo, 663-8501, Japan. 2) 1Structural Biology Research Center, Institute of Material Structure Science, High Energy Accelerator Research Organization, Ibaraki 305-0801, Japan. 3) Systems Glycobiology Group, Disease Glycomics Team, Advanced Science Institute, RIKEN, Wako 351-0198, Japan. 4) Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Tokyo 162-8601, Japan. E-mail: [email protected]


N Ε-(CARBOXYMETHYL) LYSINE (CML) IMPAIRS INSULIN SECRE TION THROUGH ROS MEDIATED MITOFUSINS DEGRADATION AND DRP1 UP-REGULAT ION Mei-Chen Lo*1,2), Ming-Hong Chen*3), Chin-I Lu1,2) , Shu-Huei Kao**1,2), and Horng-Mo Lee**1,2,4) 1)Graduate Institute of Medical Sciences, 2)School of Medical Laboratory Sciences and Biotechnology, College of Medicine, Taipei Medical University, Taipei, Taiwan. 3)Department of Pathology, Saint Paul's Hospital, Taiyuan, Taiwan. 4)Institute of Pharmaceutical Sciences and Technology, Central Taiwan University of Science and Technology, Taichung, Taiwan. *First authors **corresponding authors


DEFICIENCY OF METALLOTHIONEIN LEADS TO AGGRAVATE TH E DSS-INDUCED COLITIS IN MICE Toshifumi Tsuji1, Yuji Naito1, Tomohisa Takagi1, Hiroyuki Yoriki1, Ryusuke Horie1, Akifumi Fukui1, Akihito Harusato1, Katsura Mizushima1, Yasuko Hirai1, Kazuhiro Katada1, Kazuhiko Uchiyama1, Osamu Handa1, Hideyuki Konishi1, Nobuaki Yagi1, Hiroshi Ichikawa1, Rie Yanagisawa5, Junko Suzuki4, Hirohisa Takano3, Masahiko Satoh2, Toshikazu Yoshikawa1

1. Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan 2. Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University 3. Kyoto University, Graduate School of Engineering 4. Environmental Health Sciences Division, National Institute for Environmental Studies, Japan 5. National Institute for Minamata Disease E-mail：[email protected]

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MODULAR KINETIC ANALYSIS AS A POWERFUL TOOL FOR INV ESTIGATION OF MITOCHONDRIAL BIOENERGETICS Taku Amo1), Shigeto Sato2), Shinji Saiki2), Motoi Kikusato3), Yusuke Kawabata3), Masaaki Toyomizu3), Clement Gautier4), Jie Shen4), Shigeo Ohta5), Nobutaka Hattori2) and Martin Brand6)

1)Department of Applied Chemistry, National Defense Academy, Yokosuka 239-8686, Japan 2)Department of Neurology, Juntendo University School of Medicine, Tokyo 113-8421, Japan 3)Animal Nutrition, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan 4)Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA 5)Institute of Development and Aging Sciences, Nippon Medical School, Kawasaki 211-8533, Japan 6)Buck Institute for Research on Aging, Novato, CA, 94945, USA E-mail: [email protected]


EFFECT OF A-TOCOPHEROL AND ITS DERIVATIVE IN TNF A-INDUCED OSTEOCLASTOGENESIS IN VITRO Hirofumi Fujita1), Tetsuya Ogino2), Mio Ono1), Toshio Kukita3), Kozo Utsumi1), Junzo Sasaki1) 1)Department of Cytology and Histology, Okayama University Graduated School of Medicine, Dentistry and Pharmaceutics, Okayama, Japan 2)Department of Pathology and Experimental Medicine, Okayama University Graduated School of Medicine, Dentistry and Pharmaceutics, Okayama, Japan 3)Department of Hard Tissue Regeneration Control and Science, Faculty of Dental Science, Kyushu University, Fukuoka, Japan E-mail: [email protected]


PHOSPHORYLATION OF SER114 ON ATG32 MEDIATES MITOPHA GY Tomotake Kanki, Yoshimasa Aoki, Yuko Hirota, Yusuke Kurihara, Tetsu Saigusa, Takeshi Uchiumi, and Dongchon Kang Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812-8582, Japan E-mail: [email protected]


INCREASE OXIDATIVE STRESS IN DIABETES MELLITUS RATS DOES NOT CONTRIBUTE TO ENDOTHELIAL DAMAGE . Agus Yuwono1), Bambang Setiawan 2) 1)Department of Internal Medicine, Ulin General Hospital, Faculty of Medicine, University of Lambung Mangkurat, Banjarmasin, South Kalimantan, Indonesia Email: [email protected] 2)Department of Medical Chemistry, Faculty of Medicine, University of Lambung Mangkurat, Banjarbaru, South Kalimantan, Indonesia Email: [email protected]

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VALPROIC ACID INDUCES MITOCHONDRIA-MEDIATED IMMUNE DEFICIENCY IN LEUKOCYTES Tien-Chiang Li3), Yun-Lung Ho2), Hung-Ming Wu1,2)

1)Department of Neurology, Changhua Christian Hospital, Changhua, Taiwan 2)Inflammation Research & Drug Development Center, Changhua Christian Hospital, Changhua, Taiwan

3)Laboratory Animal Center, Changhua Christian Hospital, Changhua, Taiwan E-mail:[email protected]


ROLE OF MITOCHONDRIA IN THE DIFFERENTIATION AND RES PONSE OF C2C12 MYOTUBES TO INSULIN AND ADIPONECTIN Hsin-Chang Huang1), Yau-Huei Wei1), 2) 1)Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan. 2)Department of Medicine, Mackay Medical College, San-Jhih, New Taipei City 252, Taiwan. Email: [email protected]


A COPY NUMBER OF THE MITOCHONDRIAL DNA IN THE CELLU LAR SPHEROID. Chiba M, Hisatomi H Seikei University, Tokyo, Japan.


MITOCHONDRIAL OXIDATIVE STRESS AND LESS MINERALIZAT ION BY HYDROGEN PEROXIDE TREATMENT IN MC3T3-E1 CELL LINE Yasuko Shibata1,4), Masato Arai2), Soichiro Okano1,4), Pugdee, Kamolparn1), Toshinori Sato3), Yoko Otsuka-Tanaka3,4), Junichi Mega3,4), Hideyuki J Majima5), Yorimasa Ogata2,4), Yoshimitsu Abiko1,4)

1)Departments of Biochemistry and Molecular Biology, 2)Periodontology, and 3)Dentistry for the Disabled, Nihon University School of Dentistry at Matsudo, Chiba, Japan. 4)Research Institute of Oral Science, Nihon University School of Dentistry at Matsudo, Chiba, Japan 5)Department of Oncology, Maxillofacial Radiology Division and Department of Space Environmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

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MTDSRED2 TRANSGENIC MICE CONTRIBUTE TO STUDIES ON M ITOCHONDRIAL MORPHOLOGY

Junya Yamaguchi1),2), Satoshi Nishiyama1),2), Midori Shimanuki1), Tomio Ono1), Akitsugu Sato2), Kazuto Nakada2), Jun-Ichi Hayashi2), Hiromichi Yonekawa1),2), Hiroshi Shitara1),2) 1) Laboratory for Transgenic Technology, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan 2) Graduate School of Life and Environmental Sciences, University of Tsukuba, Ibaraki 305-8572, Japan


MATERNALLY INHERITED ESSENTIAL HYPERTENSION IS ASSO CIATED WITH THE NOVEL 4353T>C MUTATION IN THE MITOCHONDRIAL TRNA GLN GENE IN TWO HAN CHINESE FAMILIES 1Pingping Jiang，2Ronghua Li, 3Zhongqiu Lu, 3Hong Chen, 3Yanzi Meng, 3Yan Wang, and 1,2,3Min-Xin Guan 1Institute of Genetics, Zhejiangg University, Hangzhou, Zhejiang, China 2Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA 3Attardi Institute of Biomedicine, Wenzhou Medical College, Zhejiang, China


LEBER'S HEREDITARY OPTIC NEUROPATHY IS ASSOCIATED W ITH THE MITOCHONDRIAL ND1 T3866C MUTATION IN THREE CHINESE FAMILIES Juanjuan Zhang1, Xiaoling Liu1, Xiangtien Zhou1, Jia Qu1, Min-Xin Guan1,2

1School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, China; Attardi Institute of Mitochondrial Biomedicine and Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical College, Wenzhou, Zhejiang, China. 2Institute of Genetics, Zhejiang University, Hangzhou, Zhejiang, China Corresponds: [email protected]


HEARING LOSS AND HYPERTENSION ARE ASSOCIATED WITH T HE MITOCHONDRIAL 12S RRNA 1555A>G MUTATION. Min Liang1, Zhongqiu Lu2, Yanzi Meng1, Yan Wang1, Hong Chen1, Min-Xin Guan1,3

1Attardi Institute of Mitochondrial Biomedicine and Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical College, Wenzhou, Zhejiang, China. 2The first affialted Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China 3Institute of Genetics, Zhejiang University, Hangzhou, Zhejiang, China Corresponding: [email protected]

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ROLE OF MITOCHONDRIAL ROS IN RESPONSE OF MACROPHAGE TO LPS Emiko Kasahara1,2), Atsuo Sekiyama2,3), Mika Hori2,3), Keiichi Hiramoto3), Yurika Yamate1), Masayasu Inoue3), Seiichi Kitagawa1)

1) Dept. of Physiology, Graduate School of Medicine, Osaka City University 2) Division of Therapeutic Neuropsychiatry, Esaka Hospital 3) Brain Science Institute, Graduate School of Medicine, Osaka City University Email: [email protected],ac,jp


SPERM DYSFUNCTION FROM AGING IS INVOLVED IN THE OXI DATIVE STRESS Ryuhei Yamamoto1), Yukiko Minamiyama2), Hiroshi Ichikawa1), Tomohisa Takagi3), Atsunori Ishii1), Yoko Sato1), Eri Miyanishi2), Madoka Yasui1), Osamu Handa3), Yuji Naito3), Toshikazu Yoshikawa3)

1) Graduate School of Life and Medical Sciences, Doshisha University, Kyoto, 610-0394, Japan. 2) Food Hygiene and Environmental Health, Division of Applied Life Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, 606-8522, Japan. 3) Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan. E-mail: [email protected]


THE EFFECT OF KAMPO MEDICINE “DAI-KENCHU-TO” ON WOU ND HEALING OF RAT INTESTINAL EPITHELIAL CELLS Hitomi Asai1), Yukiko Minamiyama1), Hiroshi Ichikawa2), Tomohisa Takagi3), Ayaka Wada2), Yuka Ozaki2), Kanako Okazaki2), Chikako Minami2), Osamu Handa3), Yuji Naito3), Toshikazu Yoshikawa3) 1) Food Hygiene and Environmental Health, Division of Applied Life Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, 606-8522, Japan. 2) Graduate School of Life and Medical Sciences, Doshisha University, Kyoto, 610-0394, Japan. 3) Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan. E-mail: [email protected]


THE HISTIDINE AFFECTS DELAYED WOUND HEALING INDUCED BY INDOMETHACIN USING CULTURED RAT EPITHELIAL CELLS Shizuka Matsuo1), Hiroshi Ichikawa1), Yukiko Minamiyama2), Tomohisa Takagi3), Rika Fuchiue1), Akane Emoto1), Maya Suetsugu1), Kazuhiko Uchiyama3), Yuji Naito3), Toshikazu Yoshikawa3)

1) Graduate School of Life and Medical Sciences, Doshisha University, Kyoto, 610-0394, Japan. 2) Food Hygiene and Environmental Health, Division of Applied Life Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, 606-8522, Japan. 3) Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan. E-mail: [email protected]

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THE ROLE OF HISTIDINE ON WOUND HEALING USING CULTUR ED RAT INTESTINAL EPITHELIAL CELLS Kaede Hori1), Hiroshi Ichikawa2), Tomohisa Takagi3), Yukiko Minamiyama1), Madoka Nakamura1), Asami Doi2), Yaoki Kawabata2), Tomoyuki Kaneda2), Kazuhiko Uchiyama3), Yuji Naito3), Toshikazu Yoshikawa3) 1) Food Hygiene and Environmental Health, Division of Applied Life Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, 606-8522, Japan. 2) Graduate School of Life and Medical Sciences, Doshisha University, Kyoto, 610-0394, Japan. 3) Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan. E-mail: [email protected]


1-METHOXYCARBONYL-2-INDANONE SCAVENGED SINGLET OXYG EN AND PROTECTED AGAINST UV-INDUCED CELL DAMAGE Kyoko Takahashi1), Wakiko Maeda1), Ami Koda1), Shigeo Nakamura2), and Tadahiko Mashino1)

1) Department of Pharmaceutial Sciences, Keio University Faculty of Pharmacy, Tokyo 105-8512, Japan. 2) Department of Chemistry, Nippon Medical School, Kanagawa 211-0063, Japan. E-mail: [email protected]


GENERATION OF REACTIVE OXYGEN SPECIES FROM THE SPER M MITOCHONDRIA OF RATS IS AN EXCELLENT MARKER FOR THE BIOLOGICAL TOXI CITY OF ENDOCRINE-DISRUPTING CHEMICALS Eri Miyanishi1), Yukiko Minamiyama1), Hiroshi Ichikawa2), Tomohisa Takagi3), Atsunori Ishii2), Osamu Handa3), Yuji Naito3), Toshikazu Yoshikawa3) 1) Food Hygiene and Environmental Health, Division of Applied Life Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, 606-8522, Japan. 2) Graduate School of Life and Medical Sciences, Doshisha University, Kyoto, 610-0394, Japan. 3) Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan. E-mail: [email protected]

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PROTECTIVE EFFECT OF MITOCHONDRIAL TRANSCROPTION FA CTOR A

OVEREXPRESSION IN ALS MODEL MICE Nobutoshi Morimoto1), Kazunori Miyazaki1), Tomoko Kurata1), Tomomi Ide2), Yoshio Ikeda1), Tohru Matsuura1), Koji Abe1) 1)Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University, Okayama, 700-8558, Japan 2)Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyushu University, Fukuoka, 812-8582, Japan Email: [email protected]


HIGHLY AMPHIPHILLIC MANGANESE PORPHYRIN FOR THE MIT OCHONDRIAL TRAGETING ANTIOXIDANT

Shoichiro Asayama and Hiroyoshi Kawakami Department of Applied Chemistry, Tokyo Metropolitan University, 1-1 Minami-Osawa, Hachioji, Tokyo 192-0397, Japan Telephone: +81-42-677-1111 (ext.) 4972. Fax: +81-42-677-2821. E-mail: [email protected].


CLINICAL FEATURES OF 2 DIABETES MELLITUS PATIENTS W ITH HIGH TISSUE LEVEL MITOCHONDRIAL DNA A3243G MUTATION Shinji Harihara1), Kenichi Nakamura2), Mutsunori Fujiwara3), Tomio Arai4), Motoji Sawabe4), Fujio Takeuchi5), and Kaiyo Takubo2) 1) Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo 113-0033, Japan 2) Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi 173-0015, Japan 3)Department of Laboratory Medicine, Tokyo Red Cross Medical Center, Shibuya 150-8935, Japan 4)Departments of Anatomical and Clinical Pathology, Tokyo Metropolitan Geriatric Medical Center, Itabashi 173-0015, Japan

5)Department of Internal Medicine, Faculty of Medicine, The University of Tokyo, Bunkyo 113-0033, Japan

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FREQUENCY DITRIBUTION OF MITOCHONDRIAL DNA HAPLOGRO UPS IN HIDA AND MINO DOSTRICTS OF GIFU PREFECTURE －－－－THE DISTRIBUTION CAN BE SEPARATED INTO CONTRIBUTIONS FROM JOMON AND YAYOI TYPES －－－－ Hitoshi Sumi1), Shinji Harihara1), Masahi Tanaka2), Yoshiji Yamada3), Yamada, Y. (Life Sci. Res. Center, Mie Univ.), Shigeru Itoh4), and Masahiro Ishiura4) 1)Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo 113-0033, Japan 2)Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Itabashi, Japan 3)Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu 514-8507, Japan 4)Center for Gene Research, Nagoya University, Nagoya 464-8601, Japan


NEW OPTION FOR THE TREATMENT OF INFLUENZA VIRUS-IND UCED MULTIPLE ORGAN FAILURE: EFFECTS OF DICHLOROACETIC ACID DERIV ATIVE ON MITOCHONDRIAL ENERGY CRISIS Kazuhiko Yamane1), Junji Chida1), Hikaru Araki1), Yoshikazu Yamamoto2), Masaaki Hanawa2) and Hiroshi Kido1)

1) Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima, Tokushima, 770-8503, Japan. 2) R&D Department Daiichi Sankyo Healthcare Co., Ltd, Tokyo, 103-8541, Japan E-mail: [email protected]


A NEW PHENOTYPE OF MITOCHONDRIAL DISEASE CHARACTERI ZED BY FAMILIAL LATE-ONSET PREDOMINANT AXIAL MYOPATHY AND ENCEPHALO PATHY Yusuke Sakiyama1), Yuji Okamoto1), Itsuro Higuchi1), Yukie Inamori1), Yoko Sangatsuda2), Kumiko Michizono1), Osamu Watanabe1), Hideyuki Hatakeyama3), Yu-ichi Goto3), Kimiyoshi Arimura4), Hiroshi Takashima1) 1)Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan 2)Department of Psychiatry, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan 3)Department of Mental Retardation & Birth Defect Research, National Institute of Neuroscience, National Center of Neurology & Psychiatry, Tokyo 187-8502, Japan 4)Division of Neurology, Okatsu Hospital, Kagoshima 890-0067, Japan

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A-TOCOPHEROL STATUS AND EXPRESSION OF A-TOCOPHEROL TRANSFER PROTEIN IN TYPE 2 DIABETIC RATS Kimitaka Takitani1), Hiroshi Miyazaki1) 2), and Hiroshi Tamai1) 1)Department of Pediatrics, Osaka Medical College, Osaka 569-8686, Japan 2)Department of Pediatrics, Osaka Rosai Hospital, Osaka 591-8025, Japan E-mail: [email protected]


EFFECTS OF ROS ON LIFESPAN OF MITOCHONDRIAL TRANSFO RMANTS OF DROSOPHILA MELANOGASTER Amaho Ishikawa1), Yasuko Kuramitsu1), Kimitoshi Sakamoto2), Kiyoshi Kita2), and Etsuko T. Matsuura1)

1) Department of Biological Sciences, Ochanomizu University, Tokyo 112-8610, Japan. 2) Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan. E-mail: [email protected]


DROSOPHILA TFAM HAS DEFENSE FUNCTIONS AGAINST OXIDATIVE STRESS Takako Matsuda, and Etsuko T. Matsuura Department of Biological Sciences, Ochanomizu University, Tokyo 112-8610, Japan E-mail: [email protected]

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REDOX ANALYSIS OF CYTOCHROMES (B AND C) IN IN-CELL AND ISOLATED YEAST MITOCHONDRIA BY RESONANCE RAMAN SPECTROSCOPY Minoru Kakita1) and Hiro-o Hamaguchi1,2)

1) Department of Chemistry, School of Science, The University of Tokyo, Hongo 7-3-1, Bunkyo, Toyo 113-0033, Japan. 2) Institute of Molecular Science and Department of Applied Chemistry, National Chiao Tung University, 1001 To Hsuch Road, Hsinchu 300, Taiwan. E-mail: [email protected]


FUNCTIONAL ROLE of SIRT1 IN THE SKELETAL MUSCLE Toshiyuki Araki, Hitomi Takada Department of Peripheral Nervous System Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502 JAPAN E-mail: [email protected]


EFFECT OF NATURAL ANTIOXIDANT DIMERUMIC ACID ONMITO CHONDRIAL FUNCTION Naoki Imaizumi1), Ryosuke Katayama2),Hiroshi Nakao1), Yoko Aniya1) 1)Laboratory of Molecular Genetics and Pharmacology, School of Health Sciences, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan. E-mail: [email protected] 2)Musashino Research Institute for Immunity, 790 Nishizatozoe, Gusukube,Miyakojima, Okinawa 906-0106, Japan


THE ROLE OF PEROXIREDOXIN-VI IN INFLAMMATORY BOWEL DISEASE Tomohisa Takagi, Yuji Naito, Kazuhiko Uchiyama, Tomoko Oya-Ito, Katsura Mizushima, Yasuko Hirai, Toshifumi Tsuji, Hiroyuki Yoriki, Akifumi Fukui, Naohisa Yoshida, Kazuhiro Katada, Kazuhiro Kamada, Takeshi Ishikawa, Osamu Handa, Nobuaki Yagi, Satoshi Kokura, Hiroshi Ichikawa, and Toshikazu Yoshikawa Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan E-mail: [email protected]

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NON-INVASIVE IMAGING OF LUNG REDOX STATUS USING OVE RHAUSER-MRI SYSTEM AND NITROXYL RADICAL PROBES Fuminori Hyodo1), Naoki Arimura2), Kazuhiro Ichikawa1), Keiji Yasukawa1,2), Tatsuya Naganuma3), Hinako Eto1), Shinji Ito1), Kenichi Yamada2), Hideo Utsumi1) 1)Innovation center for medical redox navigation Kyushu University, Fukuoka, 812-8582, Japan,

2)Faculty of Pharmaceutical Sciences, Kyushu University. Fukuoka, 812-8582, JAPAN, 3) Japan redox Ltd Fukuoka, 812-0044 Japan.


MITOCHONDRIAL LON PROTEASE REGULATES MITOCHONDRIAL DNA COPY NUMBER AND TRANSCRIPTION Yuichi Matsushima1)2) , Yu-ichi Goto2), and Laurie S. Kaguni1)2) 1)Department of Biochemistry and Molecular Biology, and Center for Mitochondrial Science and Medicine, Michigan State University, East Lansing Michigan 428824-1319, U.S.A. 2)Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8502, Japan E-mail: [email protected]


REDOX IMAGING OF LPS-INDUCED LUNG INFLAMATION MOUSE Suguru Sato1), Ken-ichi Yamada1), Kazuhiro Ichikawa2) 1) Department of Bio-function Science, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582 Japan 2) Innovation Center for Medical Redox Navigation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582 Japan E-mail: [email protected]


CONSTRUCTION OF OMRI MAGNET FOR LARGE ANIMAL REDOX STATUS IMAGING Ryoma Kobayashi1), Suguru Sato2), Ken-ichi Yamada2), Hideo Utsumi1) and Kazuhiro Ichikawa1) 1)Innovation Center for Medical Redox Navigation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582 Japan 2)Department of Bio-function Science, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582 Japan E-mail: [email protected]

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OXIDATIVE STRESS MODULATES DIFFERENTIATION OF K562 ERYTHROLEUKEMIA CELL LINE Tetsuya Ogino1), Hirofumi Fujita2), and Kozo Utsumi2)

1) Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan. 2) Department of Cytology and Histology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.


NEGATIVE REGULATION OF MITOCHONDRIAL TRANSCRIPTION FACTOR A (TFAM) EXPRESSION BY TFAM IN NUCLEUS, PRESENTING A PART-TI ME JOB OF TFAM Eun Jin Lee and Youngmi Kim Pak Neurodegeneration Control Research Center, Department of Neuroscience, Department of Physiology, College of Medicine, Kyung Hee University, Seoul 130-731, Korea. E. mail: [email protected]


OVEREXPRESSION OF TFAM, NRF-1 AND MYR-AKT PROTECTS THE MPP+-INDUCED MITOCONDRIAL DYSFUNCTIONS IN NEURONAL CELLS Ying Piao1), Hyo-Geun Kim2), Myung Sook Oh2) and Youngmi Kim Pak1) 1)Neurodegeneration Control Research Center, Department of Neuroscience and Department of Physiology, College of Medicine, Kyung Hee University, Seoul 130-701, Korea 2)Department of Oriental Pharmaceutical Science, College of Pharmacy, Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul 130-701, Korea E-mail: [email protected]


ACCELERATED PRODUCTION OF NITRIC OXIDE BY LPS AND H YDROGEN PEROXIDE IN BV-2 MICROGLIAL CELLS Hironobu Eguchi, Noriko Fujiwara, Haruhiko Sakiyama, Daisaku Yoshihara and Keiichiro Suzuki Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan. E-mail: [email protected]

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THE NEW INSIGHT OF TRANSCRIPTIONAL ACTIVATION OF CA RBOHYDRATE RESPONSE ELEMENT-BINDING PROTEIN (CHREBP) Haruhiko Sakiyama, Noriko Fujiwara, Hironobu Eguchi, Daisaku Yoshihara, and Keiichiro Suzuki Department of Biochemistry, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan E-mail: [email protected]


MODULATION OF IRP1 ACTIVITIES BY SOD1 DEFICIENCY Daisaku Yoshihara*, Noriko Fujiwara, Haruhiko Sakiyama, Hironobu Eguchi, and Keiichiro Suzuki Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan [email protected]


INFLUENCES OF THE SOD1 DEFICIENCY ON THE GAMETE QUA LITY IN THE IN VITRO FERTILIZATION Satoshi Tsunoda1), Naoko Kimura2), Hiroyuki Abe3), Akihiko Watanabe4) and Junichi Fujii1) 1)Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, 2-2-2 Iidanishi, Yamagata 990-9585, Japan. 2)Laboratory of Animal Reproduction, Faculty of Agricultural Sciences, Yamagata University, 1-23 Wakabacho Tsuruoka 997-8555, Japan. 3)Graduate School of Science and Engineering, Yamagata University, 4-3-16 Jonan Yonezawa 992-8510, Japan. 4)Department of Biology, Faculty of Science, Yamagata University, 1-4-12 Kojirakawa, Yamagata 990-8560, Japan E-mail: [email protected]


ASSESSING HETEROPLASMIC LOAD OF MITOCHONDRIAL DNA C 1624T MUTATION IN MOTHER AND CHILD CASES WITH NEUROPSYCHIATRIC SYMPTO MS Yoko Sangatsuda1), Masayuki Nakamura1), Shuichi Ueno2), Yuichi Goto3), Akira Sano1) 1)Department of Psychiatry, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan 2) Department of Neuropsychiatry, Ehime University Guraduate School of Medicine, Ehime, 791-0295, Japan 3) Department of Clinical Laboratory, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Tokyo, 187-8551, Japan

E-mail:[email protected]

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REACTIVE OXYGEN SPECIES PLAY AS AN INDUCER IN ALTER ATION OF REMAINING RENAL MASS FOLLOWING TRANSIENT UNILATERAL RENAL ISC HEMIC INJURY. Hee-Seong Jang, Jee In Kim and Kwon Moo Park Department of Anatomy, Kyungpook National University School of Medicine, Daegu, 700-422, Korea. E-mail: [email protected]


DIFFERENTIAL EFFECTS OF MOLECULAR HYDROGEN ON MITOC HONDRIAL FUNCTION AND OXIDATIVE STRESS Ikuroh Ohsawa1) and Masashi Tanaka2) 1)Environmental Gerontology, 2)Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan E-mail: [email protected]


SYSTEMATIC SEARCH FOR MUTATIONS IN MITOCHODRIAL RES PIRATORY CHAIN DISORDERS AND FUNCTIONAL ANALYSIS FOCUSING ON NEURA L CELLS Yasushi Okazaki1), Masakazu Kohda1), Yoshimi Tokuzawa1), Yosuke Mizuno1), Yohsuke Moriyama1), Hidemasa Kato1), Masato Mori2), Kei Murayama3), Akira Ohtake4)

1) Research Center for Genomic Medicine, 4) Department of Pediatrics, Saitama Medical University, Saitama 350-1241, Japan 2) Department of Pediatrics, Jichi Medical University, Tochigi 329-0498, Japan 3) Department of Metabolism, Chiba Children's Hospital, Chiba 266-0007, Japan, E-mail: [email protected]


OXIDATIVE STRESS CONTROLS THE APKC/PAR-3 INTERACTIO N AND MAINTENANCE OF CELL POLARITY THROUGH APKC ACTIVITY BY PHOSPHATI DYLINOSITOL 3-KINASE Yousuke Horikoshi1, Kentarou Toriumi1, Naoya Nakamura1, Shigeo Ohno2 and Susumu Takekoshi1

1 Department of Pathology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.

2 Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3-9 Fuku-ura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan

Email: [email protected]

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OXIDIZED DIACYLGLYCEROL PROMOTES ACUTE HEPATIC INJU RY INDUCED BY CARBON TETRACHLORIDE THROUGH ACTIVATION OF THE PKC- NF-ΚB PATHWAY Kentarou Toriumi1), Yousuke Horikoshi1), Hideyo Henzan1), Tatsuya Takagi1), Yorihiro Yamamoto2), Naoya Nakamura1), and Susumu Takekoshi1)

1)Department of Pathology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. 2)School of Bionics, Tokyo University of Technology, 1404-1 Katakura-cho, Hachioji, Tokyo 192-0982, Japan. E-mail: [email protected]


ESSENTIAL ROLE OF FECA1, IRON-UPTAKE TRANSPORTER, I N HELICOBACTER PYLORI FOR ANTIOXIDANT ABILITY ASSOCIATED WITH SURVIVAL W ITHIN HUMAN STOMACH Hitoshi Tsugawa, Hidekazu Suzuki, Juntaro Matsuzaki, Kenro Hirata, Sawako Okada, Seiichiro Fukuhara, Toshifumi Hibi

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, 160-8582, Japan. E-mail: [email protected]


MIMECK; MITOCONDRIAL MYOPATHY WITH HYPER-CK-EMIA A NEW MITOCHONDRIAL DISEASE Yuji Okamoto1), Itsuro Higuchi1), Yusuke Sakiyama1), Shoko Tokunaga1), Osamu Watanabe1), Kimiyoshi Arimura2), Masanori Nakagawa3), ○Hiroshi Takashima1) 1) Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan. 2) Division of Neurology, Okatsu Hospital, Kagoshima, 890-0067, Japan 3) Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan E-mail: [email protected]


ROS-MEDIATED ACTIVATION OF STRESS-RESPONSIBLE MAPK AND BONE MECHANOBIOLOGY Hiroyuki Matsui1), Naoto Fukuno1), Yoshiaki Kanda1), Kohsuke Takeda2), Hidenori Ichijo2), Takayasu Kobayashi3), Shinri Tamura3), and Keiichi Sasaki1) 1) Department of Advanced prosthetic dentistry, Tohoku University Graduate School of Dentistry, Miyagi 980-8575, Japan 2) Department of Cell signaling, Tokyo University Graduate School of Pharmaceutical Sciences, Tokyo, 113-0033 3) Department of Biochemistry, IDAC, Tohoku University Graduate School of Dentistry, Miyagi 980-8575, Japan

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INCREASING MELANIN RADICAL IN MOUSE SKIN BY LOW DOS E X-RAY IRRADIATION Ken-ichiro B Matsumoto1), Ikuo C Nakanishi1), Hiroko P Indo2), Hideyuki J Majima2)

1)Radio-Redox-Response Research Team, Advanced Particle Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba 263-8555, Japan. 2)Department of Oncology and Department of Space Environmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan. E-mail: [email protected]


mRNA EXPRESSION OF NRF2 IN RELATION TO THE ACTIVITI ES AND mRNA EXPRESSIONS OF ANTIOXIDANT ENZYMES (AOEs) IN KIDNEY OF WISTAR-KYOTO (WKY) AND SPONTANEOUSLY HYPERTENSIVE RATS (SHR) Omotayo O. Erejuwa1), Siti A. Sulaiman1), Mohd S. Ab Wahab1), Kuttulebbai N. S. Sirajudeen2), Salzihan M. Salleh3), Sunil Gurtu4)

1)Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.2)Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.３)Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.4)Monash University Sunway Campus, Jeffrey Cheah School of Medicine and Health Sciences, Jalan Lagoon Selatan, 46150, Bandar Sunway, Selangor, Malaysia. E-mail: [email protected] Antioxidant enzymes


NRF2-MEDIATED HEME OXYGENASE-1 UREGULATION AS ADAPT IVE SURVIVAL RESPONSE TO GLUCOSE DEPRIVATION-INDUCED APOPTOSIS IN HepG2 CELLS Hee Geum Lee1), Young-Nam Cha2), and Young-Joon Surh1)

1)College of Pharmacy, Seoul National University, Seoul 110-799, Korea 2)College of Medicine, Inha University, Incheon, South Korea E-mail: [email protected] ([email protected])

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EVALUATION OF ANTIOXIDATIVE PROPERTIES OF FOOD FACT ORS IN RELATION TO INHIBITORY ACTIVITY OF RADIATION-INDUCED APOPTOSIS Ikuo Nakanishi1), Hiroko P. Indo2), Kei Ohkubo3,1), Nobuo Ikota4), Minako Nyui1), Ken-ichiro Matsumoto1), Kiyoshi Fukuhara5), Shunichi Fukuzumi3), Kazunori Anzai6,1), Toshiko Ozawa7,1), and Hideyuki J. Majima2)

1)Radio-Redox-Response Research Team, Advanced Particle Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba 263-8555, Japan. 2)Department of Oncology and Department of Space Environmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan. 3)Department of Material and Life Science, Graduate School of Engineering, Osaka University, ALCA, Japan Science and Technology Agency, Osaka 565-0871, Japan. 4)School of Pharmacy, Shujitsu University, Okayama 706-8516, Japan. 5)Division of Organic Chemistry, National Institute of Health Sciences, Tokyo 158-8501, Japan. 6)Nihon Pharmaceutical University, Saitama 362-0806, Japan. 7)Department of Health Pharmacy, Yokohama College of Pharmacy, Yokohama 245-0066 Japan. E-mail: [email protected]


INDUCTION OF MITOCHONDRIAL ROS AND CELL DEATH BY CY TOKINES AND ITS PREVENTION BY ESTROGEN IN RHEUMATOID ARTHRITIS FIBR OBLASTS Shigeaki Suenaga1), Hiroko P. Indo1), Hsiu-Chuan Yen2), Kosei Ijiri3), Setsuro Komiya3,4), Takami Matsuyama5), Masahiro Higuchi6), Hirofumi Matsui7), Toshihiko Ozawa8), Hideyuki J. Majima1,4)

1)Department of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan, 2)Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Kwei-Shan, Tao-Yuan 333, Taiwan, 3)Department of Orthopaedic Surgery, 4)Department of Space Environmental Medicine, 5)Department of Infection and Immunity, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan, 6)Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences Slot 5164301 West Markham Little Rock, Arkansas 72205-7199, USA, 7)Division of Gastroenterology, the Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305-8575, Japan, 8)Department of Health Pharmacy, Yokohama College of Pharmacy, Totsuka, Kanagawa 245-0066, Japan. E-mail: [email protected]


ANTI-INFLAMMATORY AND ANTIOXIDANT ACTIVITIES RELATI NG TO PROTECTIVE EFFECT ON DNA OXIDATIVE DAMAGE OF GAMMA-ORYZANOL RI CH EXTRACT FROM THAI BLACK RICE BRAN Chalermpong Saenjum1, Chaiyavat Chaiyasut1, Sunee Chansakaow1

Maitree Suttajit2, Busaban Sirithunyalug1 1Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, 2School of Medical Science, University of Phayao, Thailand E-mail: [email protected]

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PGC1Α TRANSLOCATION MAY BE ONE OF THE KEY FACTORS FOR NE URITE OUTGROWTH IN NEURONS Yuki Kambe, Kazuhiko Inoue, Takashi Kurihara and Atsuro Miyata Department of Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagosima-shi, Kagoshima, 890-8544, Japan. e-mail:[email protected]


IN VIVO IMAGING OF MITOCHONDRIAL FUNCTION IN METHAN PHETAMINE -TREATED RATS Mayumi Yamato 1), 2), Takeshi Shiba 1), 3), Wataru Kudo 1), Toshiaki Watanabe 1), Hideo Utsumi 2), and Ken-ichi Yamada 3) 1) Department of REDOX Medicinal Science, Faculty of Pharmaceutical Sciences, Kyushu University,

Fukuoka, Japan 2) Innovation Center for Medical Redox Navigation, Kyushu University, Fukuoka, Japan 3) Department of Bio-functional Science, Faculty of Pharmaceutical Sciences, Kyushu University,

Fukuoka, Japan E-mail: [email protected]


IDENTIFICATION OF SUCCINATE ASSEMBLY FACTOR 1 AND 2 IN ECHINOCOCCUS MULTILOCULARIS Kimitoshi Sakamoto1), Jun Matsumoto2), Shigehiro Enkai1), Miho Goto1), Kinpei Yagi3), Ken Katakura4), Yuzaburo Oku4), Osamu Fujita5), Tomoyoshi Nozaki6) and Kiyoshi Kita1)

1)Dept. of Biomedical Chemistry, Grad. Sch. of Med., The University of Tokyo, Tokyo 113-0033, Japan. 2)Lab. of Medical Zoology, Coll. of Bioresource Sciences, Nihon University, Kanagawa 252-0880, Japan. 3)Hokkaido Institute of Public Health, Sapporo 060-0819, Japan. 4)Lab. of Parasitology, Dept. of Disease Control, Grad. Sch. of Vet. Medicine, Hokkaido University, Sapporo 060-0818, Japan 5) Dept. of Veterinary Science, National Institute of Infectious Diseases, Tokyo 162-8640, Japan. 6) Dept. of Parasitology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan. E-mail: [email protected]

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