A Green Chemistry Company

Impact of Green Chemistry

@

Manufacturing

We shall require a substantially new manner of thinking if mankind is to

survive.

Transforming industrial manufacturing through green chemistry

~ ecoLogic’s mission statement

Green Chemistry at a glance

4

Green chemistry is the design, development, and

implementation of chemical products and processes

to reduce or eliminate the use and generation of

substances hazardous to human health and the

environment.

E-Factor Intensity Metric

5

Can we produce pharmaceutical intermediates with E-factors matching with Bulk

chemicals?

The Twelve Principles

1. Prevent waste

2. Atom Economy

3. Less Hazardous Chemical Syntheses

4. Designing Safer Chemicals

5. Safer Solvents and Auxiliaries

6. Design for Energy Efficiency

7. Use of Renewable Feedstocks

8. Reduce Derivatives

9. Catalysis

10. Design for Degradation

11. Real-time analysis for Pollution Prevention

12. Inherently Safer Chemistry for Accident Prevention

*Anastas, P. T.; Warner, J. C. Green Chemistry: Theory and Practice, Oxford University Press: New York, 1998, p.30. By

permission of Oxford University Press

E-Factor Intensity Metric

Current Members

Amgen

AstraZeneca

Boehringer-Ingelheim

Bristol-Myers Squibb

Eli Lilly and Company

GlaxoSmithKline

Johnson & Johnson

Merck & Co., Inc.

Novartis

Pfizer Inc.

Roche

Sanofi

ACS Green Chemistry

Institute®

Associate Members

Codexis

Dr. Reddy’s

DSM Pharmaceutical Products

A Green Chemistry Company, Established in Year 2009

By a team of technocrats having decades of experience in chemical and

pharmaceutical industry, with an aim to create processes and strategies

wherein, from conception to manufacture and beyond, the use of resources

and energy is optimized and the end product is created with the least

possible impact on the environment .

About ecoLogic

Approaches for better E-factor

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• Conceptual

• Atom economy

• Reduce protection/deprotection

• Avoid using derivatives

• Establishing catalytic cycle

• Using catalysts

• Practical optimization

• Improve yields – close to theoretical

• Reduce solvent volumes/improve recovery

• Reagents at molar eq. scale

• Avoid neutralizations, washings etc.

• Recovery and reusability of materials

Photo-Bromination Technology

10

• Traditionally NBS/DBDMH used (low atom economy!)

• Benzylic bromination under photochemical conditions

• Only one equivalent of HBr will be consumed

• Water is the only by-product

• Practiced on ton scale per batch

• Capacity of 30-40 tons per month

• E-factor 3.5

Example of oxidation reaction

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• Avoided Mn, Cr based reagents

• General oxidation reaction

• HBr is catalytic and actual oxidant is hydrogen peroxide

• The only by-product is water

• Light enhances the rate of the reaction

• Performed on multiple hundred kilogram scale per batch

• Running at 20-30 tons per month capacity

• E-factor 3.6

Technology for etherification

12

• Technology to remove water continuously from reaction mass

• Almost solvent-free transformation – close to mol eq. of methanol

• The reactant is being used as solvent at reaction temperature

• Catalytic amount of sulfuring acid

• Performed on ton scale batch size

• Capacity ~30 tons per month

• E-factor = 0.5

Solvent Free Synthesis

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• First Solvent-free reaction at ecoLogic

• Practiced in plant on multiple hundred kilo batch sizes

• Achieved a capacity of 15 tons/month

• The by-product is recovered and reused in the next stage as a base

Dr Pratik Patel & team

Mr Srinivasa Reddy & team

and

leadership team @ ecoLogic

14

Acknowledgements

Development Centre

Plot No. 56 Road No. 5 ALEAP Industrial Area Pragathi Nagar Kukatpally Hyderabad . Phone : 040-65813842

Manufacturing Facility

Plot Nos. 5/1, 5/2, 5/3,5/4 APIIC, Pydibheemavaram Mandal - Ranasthalam Dist,Srikakulam—532 409 Phone : 08942-220002

Corp Office

Plot No. 143

Road No. 13

Banjara Hills

Hyderabad

Phone: 040-42024371

E-mail: info@ecologitech.co.in

www.ecologitech.co.in