a structural design of the assembling multi-functional

6
A Structural Design of the Assembling Multi-functional Capsule Robot Driving Module Lining Zhang 1 , Shuxiang Guo 1,2* , Dongdong Bu 1 , Youchun Ma 1 1 Key Laboratory of Convergence Biomedical Engineering System and Healthcare Technology, The Ministry of Industry and Information Technology, School of Life Science, Beijing Institute of Technology, No.5, Zhongguancun South Street, Haidian District, Beijing 100081, China 2 Faculty of Engineering, Kagawa University, 2217-20 Hayashi-cho, Takamatsu, Kagawa 760-8521, Japan E-Mails: [email protected]; [email protected] * Corresponding author Abstract - Medical capsule robot, as a painless, non-invasive human gastrointestinal diagnosis scheme, has attracted more and more attention in modern medical treatment. At present, in the medical system, the capsule robot enters the human body orally and starts to carry out specific single functional movement through the esophagus to the intestines and stomach, until it is discharged from the body, with low working efficiency. Therefore, this paper presents a new concept of assembling multi- functional capsule robot, and designs the structure of its driving module. The robot consists of a detachable function module and a driving module. Function modules according to the clinical needs to install different modules, such as visual module, drug delivery module. The driving module is a helical structure, which is powered by a rotating electromagnetic field generated by a triaxial Helmholtz coil. The robot can realize multi-module cooperative work after assembly. The simulation result shows that the robot driving module can move stably in the pipe by rotating magnetic field. Index Terms - Assembling capsule robot, Driving moduleElectromagnetic actuation system, Rotating magnetic field. I. INTRODUCTION As a commonly used gastrointestinal examination and treatment device, endoscope plays an active role in disease examination and diagnosis [1]. Due to the structural limitations of the hard tube endoscope, gastroenterologists have possibility to make errors in endoscopy due to the use of hands, resulting in a blind area and a high rate of misdiagnosis [2]. In addition, the invasive examination method may bring discomfort to the patient, and even bruise the soft tissues in the gastrointestinal tract [3]. Therefore, a capsule endoscope that can perform gastrointestinal examination and treatment has become a research focus in recent years [4], providing a new idea for the diagnosis and treatment of gastrointestinal diseases. While capsule robotics is a promising solution in medicine, there are also challenges. At present, the common external driving methods include electrostatic driving, magnetostrictive driving, thermal driving, etc., as well as the way of using bacteria for driving, but there are still many major challenges in terms of bacterial toxicity and controllability. The Vanderbilt University developed a functional gastroscope integrated capsule robot. This robot can use four propellers to move in the liquid. Although it can achieve autonomous movement and can also collect and transmit images, its movement time is limited, its volume is too large, and its function is simple [5]. Yan et al. developed an electrically-powered miniature robot that mimics an inchworm. The robot is equipped with a camera, an inchworm mechanism, a 3D receiving coil and a control module. By changing the magnetic field generated by the external transfer coil, the doctor can control the robot's movement, make it stop at a fixed point and deliver drugs. The camera can send back images at a rate of 30 frames per second [6],[7]. Compared with other structures, the rotatable structure can generate more driving force. In terms of driving mode, due to the limited size and load of the miniature robot, the built-in driving device is not suitable as a power unit, and the external driving mode can avoid the increase of the size and load of the robot. The magnetic field drive has the advantages of rapid response; flexible control and less medium limitation [8]. Zhang et al. improved the way the robot moves by designing a capsule robot with a circular petal-shaped shape. The driving method is to inject sinusoidal alternating current with three different phase differences into the three-phase orthogonal Helmholtz coil to generate a space universal rotating magnetic field, and to control the axial force generated by the robot by changing the parameters of the incoming current, so as to control the motion speed [9]-[11]. Guo et al. developed a tiny, fish-shaped tube robot that USES a magnetic field to drive it wirelessly. The robot can control the motion of the robot by changing the amplitude and frequency of the tail by magnetic field. Since then, the team has worked on micro-robots with screw threads. The team has developed a magnetically driven propeller driven screw robot. The robot is composed of the outer thread of the fuselage and the jet port at the end of the fuselage, with two forces of its own rotation and propellers pushing. The nozzle is around the propeller, which can reduce the damage to the intestines. In this paper, it is demonstrated that rectangular spiral grooves can provide greater propulsive force than cylindrical spiral grooves under the same other conditions [12],[13]. Subsequently, a Helmholtz coil driven spiral capsule robot system was proposed. The robot is mainly composed of a shell with spiral lines and a radially magnetized permanent magnet. The outer rotating magnetic field drives the permanent magnet to rotate, so that the capsule shell, which is

Upload: others

Post on 14-Nov-2021

1 views

Category:

Documents


0 download

TRANSCRIPT

A Structural Design of the Assembling Multi-functional

Capsule Robot Driving Module

Lining Zhang1, Shuxiang Guo1,2*, Dongdong Bu1, Youchun Ma1

1 Key Laboratory of Convergence Biomedical Engineering System and Healthcare Technology,

The Ministry of Industry and Information Technology, School of Life Science, Beijing Institute of Technology,

No.5, Zhongguancun South Street, Haidian District, Beijing 100081, China

2 Faculty of Engineering, Kagawa University, 2217-20 Hayashi-cho, Takamatsu, Kagawa 760-8521, Japan

E-Mails: [email protected]; [email protected]

* Corresponding author

Abstract - Medical capsule robot, as a painless, non-invasive

human gastrointestinal diagnosis scheme, has attracted more and

more attention in modern medical treatment. At present, in the

medical system, the capsule robot enters the human body orally

and starts to carry out specific single functional movement

through the esophagus to the intestines and stomach, until it is

discharged from the body, with low working efficiency.

Therefore, this paper presents a new concept of assembling multi-

functional capsule robot, and designs the structure of its driving

module. The robot consists of a detachable function module and a

driving module. Function modules according to the clinical needs

to install different modules, such as visual module, drug delivery

module. The driving module is a helical structure, which is

powered by a rotating electromagnetic field generated by a

triaxial Helmholtz coil. The robot can realize multi-module

cooperative work after assembly. The simulation result shows

that the robot driving module can move stably in the pipe by

rotating magnetic field. Index Terms - Assembling capsule robot, Driving module,Electromagnetic actuation system, Rotating magnetic field.

I. INTRODUCTION

As a commonly used gastrointestinal examination and

treatment device, endoscope plays an active role in disease

examination and diagnosis [1]. Due to the structural limitations

of the hard tube endoscope, gastroenterologists have

possibility to make errors in endoscopy due to the use of

hands, resulting in a blind area and a high rate of misdiagnosis

[2]. In addition, the invasive examination method may bring

discomfort to the patient, and even bruise the soft tissues in the

gastrointestinal tract [3]. Therefore, a capsule endoscope that

can perform gastrointestinal examination and treatment has

become a research focus in recent years [4], providing a new

idea for the diagnosis and treatment of gastrointestinal

diseases.

While capsule robotics is a promising solution in

medicine, there are also challenges. At present, the common

external driving methods include electrostatic driving,

magnetostrictive driving, thermal driving, etc., as well as the

way of using bacteria for driving, but there are still many

major challenges in terms of bacterial toxicity and

controllability. The Vanderbilt University developed a

functional gastroscope integrated capsule robot. This robot can

use four propellers to move in the liquid. Although it can

achieve autonomous movement and can also collect and

transmit images, its movement time is limited, its volume is

too large, and its function is simple [5]. Yan et al. developed

an electrically-powered miniature robot that mimics an

inchworm. The robot is equipped with a camera, an inchworm

mechanism, a 3D receiving coil and a control module. By

changing the magnetic field generated by the external transfer

coil, the doctor can control the robot's movement, make it stop

at a fixed point and deliver drugs. The camera can send back

images at a rate of 30 frames per second [6],[7].

Compared with other structures, the rotatable structure can

generate more driving force. In terms of driving mode, due to

the limited size and load of the miniature robot, the built-in

driving device is not suitable as a power unit, and the external

driving mode can avoid the increase of the size and load of the

robot. The magnetic field drive has the advantages of rapid

response; flexible control and less medium limitation [8].

Zhang et al. improved the way the robot moves by designing a

capsule robot with a circular petal-shaped shape. The driving

method is to inject sinusoidal alternating current with three

different phase differences into the three-phase orthogonal

Helmholtz coil to generate a space universal rotating magnetic

field, and to control the axial force generated by the robot by

changing the parameters of the incoming current, so as to

control the motion speed [9]-[11]. Guo et al. developed a tiny,

fish-shaped tube robot that USES a magnetic field to drive it

wirelessly. The robot can control the motion of the robot by

changing the amplitude and frequency of the tail by magnetic

field. Since then, the team has worked on micro-robots with

screw threads. The team has developed a magnetically driven

propeller driven screw robot. The robot is composed of the

outer thread of the fuselage and the jet port at the end of the

fuselage, with two forces of its own rotation and propellers

pushing. The nozzle is around the propeller, which can reduce

the damage to the intestines. In this paper, it is demonstrated

that rectangular spiral grooves can provide greater propulsive

force than cylindrical spiral grooves under the same other

conditions [12],[13]. Subsequently, a Helmholtz coil driven

spiral capsule robot system was proposed. The robot is mainly

composed of a shell with spiral lines and a radially magnetized

permanent magnet. The outer rotating magnetic field drives the

permanent magnet to rotate, so that the capsule shell, which is

firmly connected with the permanent magnet, also rotates. The

spirals on the surface of the capsule and the liquid in the

intestinal tract produce axial thrust due to their relative

rotation, so they can advance or retreat in the liquid-filled

intestinal tract [14],[15].

In terms of functions, capsule robots have been

extensively studied in the realization of specific functions. Le

el al. proposed a passive drug delivery device based on remote

control of soft magnet. Two soft magnets are demagnetized to

release the drug inside the capsule. The drug release applies a

suitable magnetic field to the capsule axial direction. The

attraction between the two soft magnets causes the capsule

robot to reconnect the drug delivery module under the action

of the soft magnet and return to the original state [16]. Guo et

al. designed a targeted drug delivery robot, which rotates the

internal magnets by changing the external magnetic field to

release drugs from attraction to repulsion [17]. Manh et al.

designed a biopsy capsule robot that controls the external

magnetic field to rotate the magnet connected with the blade

inside to cut tissue and take it out of the body [18].

All the above robots have good motion modes and

functions, but their functions are single and cannot be freely

matched with the required functional modules. This paper

presents the concept of a new type of multifunctional capsule

robot, which can be assembled, and designs the structure of its

driving module. The robot consists of a detachable function

module and a driving module. Functional modules different

modules are installed according to clinical requirements. The

driving module is a helical structure, which is powered by a

rotating electromagnetic field generated by a triaxial

Helmholtz coil. After assembly, the robot and the realization

of multi-module work together. The structure of this article is

as follow. Section II described the design of the mechanical

structure and the magnetic field, and also elaborated the

working mechanism of the assembled multifunctional capsule

robot. In Section III, the dynamic model of the assembled

multifunctional capsule robot driving module was established.

Section IV evaluated the driving module. And finally, section

V describes the conclusions and future work.

II. MECHANICAL STRUCTURE AND MAGNETIC FIELD DESIGN

A. The Design of Mechanical Structure

In this paper, the assembled multifunctional capsule robot

is composed of two modules, namely the driving module and

the function module. When the robot works, the driver module

and the required functional modules must be assembled

together. The driving module is composed of front and rear

parts, each part of which is composed of a spiral structure and

a driving permanent magnet. The spiral structure provides a

driving force for the robot in the direction of motion. The

radial magnetized permanent magnet rotates in a plane

perpendicular to the direction of motion under the action of the

external magnetic field. Since this paper focuses on the design

of the driving module structure, the function module is

replaced by two cylindrical structures for further development.

Each structure has a threaded structure and is connected

manually during installation. All structures are made of resin

and produced by a 3D printer. According to the clinical

requirements for the robot's versatility, the mechanical

structure shown in Figure 1 was designed, and its structural

parameters were shown in Table 1.

Fig. 1 The structure of the assembling multi-functional capsule robot

TABLE I

THE MAIN STRUCTURAL PARAMETERS OF THE DESIGNED MODULE

Property parameter

The length of each driving module 18cm

The radius of the driving module 8cm

The number of each driving module

screw thread

2.5

The size of the radial magnetized

permanent magnet

Ø6×2mm

The length of thread at connection 4mm

The material of the module Resin

B. The Design of External Magnetic Field

Helmholtz coils can generate a uniform magnetic field at

their central axis, and are often used as magnetic field

generating devices. In previous research, Yang used the

rotating magnetic fields generated by two pairs of Helmholtz

coils perpendicular to each other to move the robot [19]. In

order to build a rotating magnetic field generator for the

assembled robot. In this paper, a three-axis Helmholtz coils are

used to generate a rotating magnetic field to rotate the radial

magnetized permanent magnet and drive the external spiral

structure to rotate in the liquid to generate propulsion. The

common Helmholtz coils are round and square coils. In this

paper, square coils are used to design the peripheral magnetic

field of the robot. The parameters of three-axis Helmholtz

coils designed in the experiment are shown in Table II.

TABLE II

THE PARAMETERS OF THREE-AXIS HELMHOLTZ COILS DESIGNED IN THE

EXPERIMENT Property x-axis y-axis z-axis

The length of side 18cm 22cm 26cm

turns per coil 500 620 740

The magnetic field

intensity

3880.9 A/m 3880.9 A/m 3880.9 A/m

The diameter of wire 1.25mm 1.25mm 1.25mm

The material of the

conductor

copper copper copper

C. Working mechanism of the assembled multifunctional

capsule robot

A multifunctional capsule robot is proposed in this paper.

In actual clinical applications, due to many complicated

problems in the process of intestinal diagnosis and treatment,

robots are encouraged to have multiple functions to solve this

problem. In doing the preparatory work, the doctor assembles

the robot driving module with one or more of the required

functional modules, such as the vision module and the tissue

sampling module. Before swallowing the robot, the patient is

given an appropriate amount of liquid to drink. The robot

rotates in the liquid environment and moves with the thrust of

the liquid, which ensures that the robot is immersed in the

liquid environment and obtains sufficient thrust. At the same

time, the liquid can lubricate the cavity of the human body,

which is helpful for the robot to pass through the narrow area.

After the patient swallows the robot, the external magnetic

field starts to work. The doctor controls the magnetic field by

controlling the current parameter of the external coil to make

the robot work.

(a) The patient swallowed the robot.

(b) The doctor finds suspicious lesions through visual modules.

(c) The living sampling module starts to work, takes out the sample and

saves it in the module.

(d) The robot passes out of the body.

Fig.2 The working mechanism diagram of the assembled multifunctional

capsule robot.

When the doctor finds the suspicious lesion location through

the vision module, the tissue sampling module starts to work,

takes out the sample and saves it in the module. Finally, the

robot passes out of the body through the anus. The collected

robots are disassembled for the next assembly. The working

mechanism diagram of the assembled multifunctional capsule

robot is shown in Fig. 2.

III. THE DYNAMICS ANALYSIS OF THE ROBOT DRIVING MODULE

AND SIMULATION

According to the previous study [20], when an object is

immersed in a liquid and moves, a layer of fluid is attached to

its surface, which is subject to viscous resistance from the

fluid. The principle of viscous resistance is as follows: the

fluid close to the surface of the object is carried away due to

relative motion, and a velocity gradient is formed near the

surface of the object. There is internal friction between each

layer inside the fluid, and the object is subject to resistance.

The robot is in a laminar flow environment, and the water in

the pipe can be regarded as Newtonian fluid. According to

Newton's law of internal friction, the viscous resistance can be

calculated as follows:

cc

vf A

l= (1)

where, cf is the circumferential viscous resistance generated

by robot rotation, is the dynamic viscosity of liquid, A is

the contact area where robot and fluid move relative to each

other, and /cv l is the circumferential velocity gradient.

Finite element method (FEM) is an analytical method that

decomposes the whole into small parts, which can effectively

analyze the dynamics of a complex whole. The overall

mechanical characterization can be obtained by integrating the

local analysis. In this paper, the finite element method is used

to analyze the dynamics of the robot. The geometric structure

of the robot is shown in Fig. 3.

Fig. 3 The geometric structure parameters of the robot

Selecting an infinitesimal on the spiral rib, the

circumferential viscous resistance generated by the fluid can

be calculated by the following two formulas:

1

1

cc s

vdf dA

l= (2)

2

2

cc s

vdf dA

l= (3)

where, 1cf and 2cf are the circumferential viscosity

resistance of the left and right spiral rib, sdA is the trajectory

area of the circumferential rotation of the finite element, 1l is

the distance between the left side of the spiral rib and the inner

wall of the pipe, and 2l is the distance between the right side

of the spiral rib and the axis of the robot. These two distances

can be calculated using the following formula:

1 ( )l R c R H h= + − − + (4)

2l R H h= − + (5)

where, R is the radius of the robot, H is the height of the

spiral rib, and h is the radial height of the infinitesimal to the

bottom of the spiral rib. The calculation formula of the

trajectory of the robot's rotation is as follows:

sdA Cds= (6)

where, ds is the width of the infinitesimal, and C is the

length of the circumferential rotation trajectory. ds can be

expressed as follows:

tan

dhds

= (7)

where, dh is the height of the infinitesimal, and is the

helix angle. The trajectory length C of the circumferential

rotation of the robot can be expressed as:

2 ( )

cos

R H hC

− += (8)

where, is the spiral rib inclination angle. In addition, the

mechanical model of the viscous resistance at the top and root

of the spiral rib can be established directly without the use of

finite element method. The calculation formula is as follows:

3

2

cosc

R Rf a

c

= (9)

4

( )( )

cosc

R H R Hf a

H c

− −= −

+ (10)

2 f = (11)

where, 3cf is the adhesion force on the crest of screw thread,

4cf is the adhesion force on the root of thread, a is the width

of the crest of screw rib thread, is the rotation angular

velocity of the robot, f is the rotation frequency of the robot,

and is the pitch of the thread. By comprehensively applying

all kinds of above, the total stress model of the robot can be

solved:

1 2 3 4

0 0( )

H H

c c c c cf n df df f f= + + + (12)

1 2 3 40 0

( ( ) ( ) ( ))H H

c c c c cM n R H h df R H h df f R f R H= − + + − + + + − (13)

where, n is the number of threads on the surface of the robot.

Furthermore, the component of the circular viscosity

resistance of the robot in the direction perpendicular to the

paper surface is expressed by 12cf , which can be calculated

by the following formula:

12 1 20 0

( )H H

c c cf n df df= + (14)

It can also be expressed by formula:

12tan

ac

ff

= (15)

In the equation, af is the axial propulsive force received

by the robot, which makes the robot move forward and

backward along the tube axial direction.

The screw structure of the robot affects the axial

propulsive force and torque of the robot. In order to study the

influence of robot geometric parameters on the axial

propulsive force and rotation moment, we analyzed the

influence of multiple geometric parameters on the mechanical

model and established the relationship between the geometric

parameters and the mechanical model. On the MATLAB

software platform, it is assumed that the robot rotation

frequency is 10 Hz , the number of threads n is 4, and the

spiral rib inclination angle is 30°.The fluid environment is

the water in 20℃, and then the analysis results of each

variable are shown in Fig. 4. (a) The robot radius R is the

variable: the radius R of the robot ranges from 5mm to

15mm, the thread depth H is 4mm, the distance between the

crest of screw thread and the inner wall of the pipe c is 2mm,

and the helix angle is 45°. (b) The robot thread depth H is

the variable: the robot thread depth H ranges from 1mm to

5mm, the robot radius R is 10mm, the distance between the

crest of screw thread and the inner wall of the pipeline c is

2mm, and the helix angle is 45°. (c) The distance between

the crest of screw thread and the inner wall of the pipeline c

is variable: The distance between the crest of screw thread and

the inner wall of the pipeline c ranges from 1mm to 5mm, the

robot radius R is 10mm, the thread depth H is 4mm, and the

helix angle is 45°. (d) The helix angle is variable: the

helix angle ranges from 10° to 60°, robot radius R is

10mm, thread depth H is 4mm, and the distance between the

crest of screw thread and the inner wall of the pipeline c is

2mm.

In this section, the robot driver module is placed in a

water-filled pipe for simulation in ANSYS [21]. The flow field

R(m)

(a) The robot radius R is the variable.

H(mm)

(b) The robot thread depth H is the variable.

c(mm)

(c) The distance between the crest of screw thread and the inner wall of the

pipeline c is variable.

(°)

(d) The helix angle is variable.

Fig.4 The analysis results of each variable.

used in the simulation must be based on the 3D model of the

robot. The simulation environment is built in a pipe with a

diameter of 19mm filled with water. Boolean operation is

performed between the 3D model and the flow field. Subtract

the 3D model of the robot from the flow field to obtain the

hydrodynamic object, as shown in Fig. 5.

Fig. 5 The simplified 3D model in the flow field.

In many works of fluid mechanics analysis, the mesh of

the robot and the flow field are identified as the key factors. In

addition, the amount of the mesh determines the effectiveness

and computational complexity of hydrodynamic analysis. The

mesh generation results of the 3D model and flow field of the

robot are shown in Fig. 6. The total number of elements and

nodes is 345,495 and 64,735.

Fig. 6 The mesh generation results of the model.

Then ANSYS was used for finite element calculation. In

this paper, driving module adopts the Weilai 8000 resin as

materials and add the parameters of the material. Modulus of

elasticity is 2500 MPa, poisson ratio is 0.41, and the density is

1.05 3/g cm . Import geometry model. Solids, surfaces, and

lines can all be used for modal analysis. To analyze the

performance of the propulsion structure, the simulation only

intercepts the front part of the driving module as the geometric

model import. The geometric structure is consistent with the

robot parameters in Table I. The part of the geometric

structure can shorten the computation time and improve the

simulation efficiency. Because the mesh directly affects the

accuracy of simulation, the mesh is controlled by the

geometric dimension, the mesh size is set as 1.0mm, and the

geometry is meshed.

Adds a rotational load to the geometry. Set the speed of

rotation with the central surface as the centre of rotation.

Based on the magnetic field driving frequency range, it is

assumed that the robot can rotate synchronously with the

magnetic field, with the speed set to 120rpm. Modal analysis

can obtain the inherent frequency of the model. Table III

records the inherent frequency of the driving module when the

rotating load is added. It can be seen from the table that the

first-order inherent frequency of the driving module in the

rotating state is 9553.6Hz, and the inherent frequency will

increase with the increase of the order, until the eighth order

inherent frequency reaches 24688Hz. The first-order inherent

frequency of 9553.6Hz is much higher than the maximum

driving frequency of the external magnetic field of 30Hz. After

that, the inherent frequency of each order is much higher than

the maximum frequency of the external magnetic field in the

experiment, which will not cause the robot resonance.

Fig.7 The maximum principal stress diagram under rotation state.

Mc

(N/m

)

fa (

kA

/m)

fa (

kA

/m)

fa (

kA

/m)

fa

(k

A/m

)

Mc

(N/m

)

Mc

(N/m

)

Mc

(N/m

)

In the simulation, the maximum principal stress of the

driving module is solved in the pipe filled with water. The

maximum principal stress diagram under rotation state are

solved as shown in Fig.7. As can be seen from the figure, the

maximum principal stress is located at the axis of the structure

with a value of 1055.1Pa, which is far less than the tensile

strength of 35MPa of the material, so the material will not

break due to rotation.

TABLE III

THE INHERENT FREQUENCY OF THE DRIVING MODULE IS SOLVED Order Frequency Order Frequency

1 9553.6Hz 5 21570Hz

2 9770.5Hz 6 21803Hz

3 12056Hz 7 22938Hz

4 17337Hz 8 24688Hz

The total deformation of the driving module under the

action of rotating load is shown in Fig.8. It can be seen from

the figure that the maximum value of the total deformation of

the structure under the rotation state goes to zero, which is far

smaller than the geometric size of the screw structure.

Therefore, the screw can keep its original shape in the rotation.

Fig.8 The total deformation of the driving module under the action of rotating

load.

V. CONCLUSIONS

In this paper, a new concept of assembling multi-

functional capsule robot is presented, and its driving module is

designed. The driving module is designed by SolidWorks

software and produced by 3D printer. Then it introduces the

design of the driving module, including the structure design,

the external magnetic field design and the working mechanism.

A three-axis Helmholtz coil creates a rotating electromagnetic

field that rotates the driving module to power the robot. After

assembly, the robot can realize multi-module cooperative

work. Then the mechanical analysis and simulation of the

robot show that the structure of the driving module can

provide enough power and ensure its safety and stability by

rotating magnetic field. In the future work, carry out the design

of function module.

REFERENCES

[1] H. Mateen, R. Basar, A. Ahmed, et al. “Localization of Wireless

Capsule Endoscope: A Systematic Review,” IEEE Sensors Journal,

vol.17, no. 5, pp. 1197-1206, 2017.

[2] A. Khanicheh, A. Shergill “Endoscope design for the future,”

Techniques in gastrointestinal endoscopy, vol. 21, no. 3, pp. 167-173,

2019.

[3] C. Hoon-Jai, T. Satoshi, C. Myung-Gyu, et al. “Current status and future

directions of capsule endoscopy,” Gastroenterology Research and

Practice, pp. 1-2, 2016.

[4] J. Troccaz, G. Dagnino, G. Yang, “Frontiers of medical robotics: from

concept to systems to clinical translation,” Annual Review of

Biomedical Engineering, vol. 21, pp. 193-218, 2019.

[5] M. Beccani, C. D. Natali, G. Aiello, et al. “A magnetic drug delivery

capsule based on a coil actuation mechanism,” Procedia Engineering,

no. 120 pp. 53–56, 2015.

[6] J. Gao, G. Yan, “Design and implementation of a clamper-based and

motor-driven capsule robot powered by wireless power transmission,”

IEEE ACCESS, vol. 7, pp. 138151-138161, 2019.

[7] J. Gao, G. Yan, Y. Shi, et al. “Optimization design of extensor for

improving locomotion efficiency of inchworm-like capsule robot,”

Science China technological sciences, vol. 62, no. 11, pp. 1930-1938,

2019.

[8] Z. Wang, S. Guo, Q. Fu, et al. “Characteristic evaluation of a magnetic-

actuated microrobot in pipe with screw jet motion,” Microsystem

Technologies, vol. 25, no. 2, pp. 719-727, 2019.

[9] Y. Zhang, Z. Yu, H. Yang, et al. “Orthogonal transformation operation

theorem of a spatial universal uniform rotating magnetic field and its

application in capsule endoscopy,” Science China Technological

Sciences, vol. 60, no. 6, pp. 854–864, 2017.

[10] Y. Zhang, J. Chen, Y. Zhang, K. Meng, “Self-centering characteristics

of a petal-shaped capsule robot,” Science China technological sciences,

vol. 62, no. 4, pp. 619-627, 2019.

[11] Y. Zhang, H. Yang, D. Yang, X. Liu, et al. “Polynomial profile

optimization method of a magnetic petal-shaped capsule robot,”

Mechatronics, vol. 65, 2020.

[12] Q. Pan, S. Guo, T. Okada, “ A novel hybrid wireless microrobot, ”

International Journal of Mechatronics and Automation, vol. 1, no. 1,

pp. 60-69, 2011.

[13] Q. Fu, S. Guo, S. Zhang, H. Hirata, et al. “ Characteristic evaluation of a

shrouded propeller mechanism for a magnetic actuated microrobot,”

Micromachines, vol. 6, no. 9, pp. 1272-1288, 2015.

[14] Q. Fu, S. Guo, S. Zhang, et al. “Performance evaluation of a

magnetically actuated capsule microrobotic system for medical

applications,” Micromachines, vol. 9, no. 12, 2018.

[15] Z. Wang, S. Guo, Q. Fu, et al. “Characteristic evaluation of a magnetic-

actuated microrobot in pipe with screw jet motion,” Microsystem

Technologies, vol. 25, no. 2, pp. 719-727, 2019.

[16] V. Le, H. Rodriguez, C. Lee, et al. “A soft-magnet-based drug-delivery

module for active locomotive intestinal capsule endoscopy using an

electromagnetic actuation system,” Sensors and Actuators A: Physical,

243: pp. 81-89, 2016.

[17] J. Guo, Z. Bao, Q. Fu, S. Guo, “Design and Implementation of a Novel

Wireless Modular Capsule Robotic System in-pipe,” Medical &

Biological Engineering & Computing, 10.1007/s11517-020-02205-w,

2020.

[18] M. C. Hoang, V. H. Le, J. Kim et al. “Untethered Robotic Motion and

Rotating Blade Mechanism for Actively Locomotive Biopsy Capsule

Endoscope,” IEEE Access, vol.7, pp. 93364-93374, 2019.

[19] S. Guo, Q. Yang, L. Bai and Y. Zhao, “A Wireless Multiple Modular

Capsule Robot,” Proceedings of the 2018 13th World Congress on

Intelligent Control and Automation, pp. 147-152, 2018.

[20] S. Guo, Q. Yang, L. Bai and Y. Zhao, “Development of Multiple

Capsule Robots in Pipe,” Micromachines, vol. 9, no. 6, 2018.

[21] S. Guo, Y. He, L. Shi, S. Pan et al. “Modeling and experimental

evaluation of an improved amphibious robot with compact structure,”

Robotics and Computer-Integrated, vol. 51, pp. 37-52, 2018.