abstract bajka balazs

8/17/2019 Abstract Bajka Balazs

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University of Medicine and Pharmacy Tîrgu Mureș

School of Doctoral Studies

Summary of PhD Thesis:

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ST$OSS

PhD candidate: %a,-a %al./sScienti0c coordinator: Prof1 Dr1 )a2il1 %enede- #mre

The aim :

The involvement of the left main lesions in the genesis of acute coronary syndromes3 the

com4le5ity of the lesions and the method of revasculari/ation are im4ortant factors

in6uencing the short and long term survival1 The aim of this study 7as to evaluate the

incremental value of the Coronary Com4uted Tomogra4hy "ngiogra4hy 8CCT"9 in 4roviding

ne7 information to the classical coronarogra4hy for the characteri/ation of left main lesions

and in 4redicting the 4rocedural com4le5ity in 4atients 7ith signi0cant left main stenosis1

Study 1

This 4ros4ective3 non(randomi/ed study included a num2er of ; 4atients 7ith acute

coronary syndrome 7ithout ST elevation in 7hich coronarogra4hy sho7ed a signi0cant !M

stenosis1 This study 7as 4erformed in order to follo7 and com4are the evolution of the

4atients 7hose indication for revasculari/ation 2y PC# or surgical revasculari/ation 8C"%'9

7as esta2lished 2ased u4on the information 4rovided 2y classical coronarogra4hy and CCT"

to those in 7hom the indication for revasculari/ation 7as 2ased only u4on the angiogra4hic

Synta5 score1 #n grou4 < 7e have enrolled 3=?9 at 7hom the evaluation of

the !M lesion 7as reali/ed 2ased u4on the angiogra4hic Synta5 score associated 7ith the

informations o2tained 7ith CCT"1 #n grou4 7e have enrolled 3=? of cases3


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Des4ite of the fact that Synta5 score calculated angiogra4hically 7as similar in 2oth

grou4s of 4atients3 in grou4 < the interventional revasculari/ation rate of the !M lesion 7as

E>3 ? com4aratively 7ith =@? in grou4 1 &e divided 2oth grou4s of 4atients into ;

su2grou4s: su2grou4 " 7ith a lo7 Synta5 score 8F 93 su2grou4 % 7ith an intermediar

Synta5 score 8;(;93 su2grou4 C 7ith a high Synta5 score 8G;9 #n 4atients 7ith a high

Synta5 score 8G;9 the indication for interventional revasculari/ation 7as >>3>>? in grou4 <

in com4arison 7ith =@? in grou4 84F@3@=91 #n grou4 ? in com4arison 7ith grou4 7here surgical intervention 7as recommended in @?

of 4atients1 Conservative treatment 7as indicated in grou4 < at ? in grou4 < and 4atients 7ith myocardial ischemia and signi0cant !M stenosis at

the coronarogra4hic evaluation3 each 4atient 2eing non(invasively e54lored 7ith CCT"

multislice >A follo7ed 2y coronarogra4hy and 4ercutaneous revasculari/ation1 The

o2,ectives of this study 7ere to 4rove the correlation 2et7een the Synta5 score evaluated

7ith CCT" and coronarogra4hic Synta5 score in signi0cant !M lesions3 to esta2lish an

eventual correlation 2et7een the calcium scoring evaluated 7ith CCT" and Synta5 score

determined 7ith CCT" and coronarogra4hy in 4atients from the grou4 study and 4atients

7ith lo73 intermediar and high ris-3 and to identify 4ossi2le 4redictors for com4le5 PC#

4rocedures evaluated 7ith CCT" and coronarogra4hy1

Results

&e did not 0nd any statistical signi0cant dierences 2et7een Synta5 score determined 7ith

CCT" and coronarogra4hyc Synta5 score1 "ngiogra4hic Synta5 score 7as slightly lo7er than

that calculated 7ith CCT" in the studied grou4 7ithout 4ointing out a statistical signi0cant

dierence1 813 #C =? 8@39( for angiogra4hic Synta5 score and 8rJ @3AE>3 4J@1@@;;3 #C

=? 81E;9( for

angiogra4hic Synta5 score and rJ @3A@A3 4J@1@A9( for CCT"


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Synta5score1 &e have follo7ed the correlation 2et7een the e5istence of coronary

calci0cations determined 7ith calcium scoring through CCT" and !L systolic dysfunction

uanti0ed 7ith !L+1 Our results sho7ed an insigni0cant statistical negative correlation

2et7een calcium scoring and !L+ rJ(@33A and in the su2grou4 7ith high

ris- the calcium scoring 7as 3> 84 J@1@@@A19 The medium volume of the !M 4laue 7as

signi0cantly 2igger in the su2grou4 of 4atients 7ith CCT" Synta5 score 7hich is higher in

com4arison 7ith the 4laue volume found at the su2grou4 of 4atients 7ith intermediar

Synta5 score3 this statistical signi0cant dierence 2eing also noticed 2et7een the

su2grou4s 7ith lo7 and intermediar ris-1 8the medium volume E;3=mm; for the lo7 ris-

su2grou4 vs1 B>mm;( for the intermediar ris- su2grou4 vs1 vs 1BE3 4J@1@


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abstract bajka balazs

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