acute inhalation injury by : ziba loukzadeh, m.d occupational medicine department yazd university of...
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Acute Inhalation Injury
By : ziba Loukzadeh, M.DBy : ziba Loukzadeh, M.D
Occupational Medicine departmentOccupational Medicine department
Yazd University of Medical SciencesYazd University of Medical Sciences
Types of inhaled substances Aerosol Fume Mist Gas Vapor Smoke Dust
Properties of inhalants Gas (water solubility)
High water solubility: ammonia, SO2,HCL Immediate injury to upper airway person quickly leave area
low water solubility: Phosgene, ozone, NOX Injury of terminal bronchiole & alveolus person remain in area
Intermediate water solubility: chlorine
Properties of inhalants
Particle (size) :
>10µm :upper airway 2.5-10µm :lower air way <2.5µm :lung parenchyma
Acid (chlorine, HCL,SO2, NOX, phosgene) coagulation
Alkali (ammonia) liquefaction
Reactive o2 species(ozone, NOX, chlorine) Lipid peroxidation
Pathophysiology
Direct contact & tissue damage Direct smooth muscle contraction Stimulation of neuronal receptors
Influx of inflammatory cells & mediators Leakage of interstitial fluid & edema Decrease epithelium’s barrier function
Classification of injury Acute (1-2 days of exposure)
Laryngeal edema Airflow obx- asthma & bronchitis Pneumonitis, pulmonary edema ARDS
Persistent sequelae( weeks to months) COPD RADS (Reactive Airway Dysfunction Syndrome) Bronchitis Bronchiolitis obliterans BOOP
Upper airway injury- presentation
Burn of skin, eyes, nasal & throat Rhinitis Conjunctivitis lacrimation Sputum production Coughing & sneezing Airway obx
tissue edema, thick secretion, sloughed cells Laryngospasm
hoarseness ,stridor
Conductive airway Acute
Tracheobronchitis & bronchorrhea Hospitalization for observation
Asymptomatic person+ objective evidence of respiratory compromise
Airflow O2sat Abnormal CXR
Asymptomatic person+ history of intense exposure
With respiratory symptoms
Conductive airway
Baseline spirometry repeat after 24-48h
Significant decrement: FEV1≤80% Decrease ≥ 10% from baseline
Conductive airway Symptomatic person without decrement in
airflow Inhaled steroid +bronchodilator
Symptomatic person with airflow obx Short course of systemic steroids AND Inhaled steroid +bronchodilator
Conductive airway( chronic injury ) COPD (chlorine, SO2)
Intensity of exposure Smoking Pre-existing pulmonary dx Rx
Smoking cessation Bronchodilator Steroids O2
Conductive airway( chronic injury) RADS (sulfuric acid, chlorine, ammonia,
smoke, household cleaner) Persistence of airway reactivity after
inhalational injury Single, acute, high intensity exposure Previous exposure: - Pre-existing respiratory dx: - Rx
Steroids bronchodilators
Lung parenchyma (acute injury ) Exposure
Low water soluble Massive high/intermediate water soluble
Pneumonitis dyspnea, cough Hypoxemia Mild restriction Diffuse bilateral infiltration Rx:o2 +/- mechanical ventilation
Pulmonary edema , ARDS
Lung parenchyma (chronic injury) Bronchiolitis obliterans (ammonia,
mercury, NOx, SO2) Survivors of acute lung injury asymptomatic
period irreversible obx (after 1-3 wks) PH/EX: early inspiratory crackles CXR: NL or hyperinflation
Infiltration: generally – PFT: Obx +/- restriction Rx: 6-month trial of steroids
Copyright © 2007 by the American Roentgen Ray Society
Pipavath, S. J. et al. Am. J. Roentgenol. 2005;185:354-363
--Constrictive bronchiolitis pattern in 41-year-old male double lung transplant recipient with bronchiolitis obliterans syndrome
Lung parenchyma (chronic injury) BOOP (ammonia, mercury, SO2)
Proliferative bronchiolitis Like Community acquired pneumonia:
Non-productive cough, DOE, Malaise, fever, weigh loss, …. PH/EX: NL or late respiratory crackle CXR: Bilateral, most peripheral patchy opacity start as
focal lesions, wax & wane PFT: NL or restrictive Rx: at least 6-month steroid
Dramatically response
Evaluation ABG CXR PFT (spirometry, peak flowmetry) Methacholine challenge Lung Bx 24h observation for low water soluble
inhalants
Management Removal from exposure Irrigation with large amount of water Suction of secretion Airway obx
Inhaled epinephrine Endotracheal intubation Tracheotomy
O2 if hypoxemia Bronchodilator Corticosteroids
No influence Extensive edema: suggested
Prophylactic Antibiotic: NO Management of Skin & mucosal surface burns Ophthalmologic consultation
Prevention
Engineering controls Regular maintenance Worker training Plan to handle accident
Evacuation plan Availability of emergency provision (o2,
shower, respirator)
Ammonia
Manufacturing industry Manufacture of explosives, cyanide, synthetic
fiber, plastic Chemical industry
Petroleum refining Agricultural industry
Soil fertilizer
Ammonia
Highly water soluble Injury:
Thermal burn Alkali burn
Irritation of eye, skin & upper & conductive airway
Parenchymal injury in high exposure Biphasic pattern
Chlorine (CL2)
Use: Bleaching agent (textile & paper industry) Water purification (swimming pool & sewage
treatment) Intermediate water solubility Mixing of chlorine compound & other
substance: Chlorine + ammonia: chloramine gas Household bleach+ phosphoric acid : CL2 gas
NOx Exposure
Mining Acetylene welding explosive manufacturing In closed area with engines Agricultural worker ( silo fillers dx)
Low water soluble
Phosgene (low water soluble) Used to catalysis reactions
Polyurethane resin TDI Pesticide Dye
Produced via heat decomposition of Solvents Paint remover Dry cleaning fluid Methylene chloride
Systemic illness from inhaled toxins (inhalation fever)
Background Various causes Similar features Flu-like symptoms Self-limited Important differential diagnosis
- Inhalational lung injury
- HP- Infections
Characteristics Symptoms: fever, chills, headache, cough,
chest tightness, minimal dyspnea, malaise, myalgia
Signs: fever, tachycardia, tachypnea, occasionally crackles
Develop 4-8 h after exposure Lab data: leukocytosis CXR : NL PFT : NL Self-limiting: 24-48h
Metal fume fever Causes:
- Zinc oxide - Other metals: Mg, Cu, Cr, Ir, Ni, Ag, Al, Hg
- Cd: acute lung injury
- ZnCl2: acute lung injury Jobs: Brass foundry, Welding or Flame-
cutting of galvanized metal Constitutional symptoms + metallic taste
Organic Dust Toxic Syndrome (ODTS)
Causes: moldy or damp silage, hay, moldy wood chips
Silo unloader’s syndrome (Vs. silo filler’s disease) /atypical farmer’s lung
Summer and fall Atopy a risk factor DD: farmer’s lung (HP)
Polymer Fume Fever
Causes: pyrolysis (300 –750ºC) products of polytetrafluoroethylene resins (Teflon)
Jobs: welding or flame-cutting of metals coated with PTFE, molding or extruding machines, cigarette smoking
No tolearnace DD: acute lung injury
Smoke inhalation In fire exposed person Smoke
Thermal content: supraglotic region Chemical content: vary from fire to fire
Irritants Acrolein Ammonia Chloride HCL SO2 phosgene
Chemical asphyxiants CO (incomplete combustion) Cyanide (combustion of acrylic, nylon, polyurethane)
Significant smoke inhalation Steam exposure Closed space Exposure to plastic fumes Burn of facial hair Altered consciousness Respiratory symptoms Lactic acidosis COHg>20%
Smoke inhalation (management)
O2 Evaluation of COHg & serum PH Upper airway burn: endotracheal
intubation Significant smoke inhalation: 24h obseve
Thank you!
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