AD Report 68-92 February 1968

Surveys of Foreigi Scientific and Technical Literature

DRUG RESISTANT DISEASES

'K ATD Work Assigrment no. A-68-42

Dietribution othia Docr'- cnt is Nnlimted. Itmay be reZeaaed to the CZearin houe epartmentof Connerce, for sale to the General Public

Aerospace Technology DivisionLibrary of Congress

I: T~s rportwas Forward

t Ths rportwasprepared In response to a request fromthe Medical Intelligence office, Office of the SurgeonGeneral, Departmient of the Amiy.

L

T AB LE O F CO0N TE NT S

Introduction . . . . . . . . .

Ilo Malaria .. ********* 2

1I. Japanese B Encephalitis * *** 9

III. Melilidosia . . 0 22

IV. Vectors. . . . . o o 27

V. Related Atmospheric and Environmental Aspects 47

Appendix -MEDLARS Bibliography 1964 to date

BEST AVAILABLE COPY

I I. Ma ar~eB Introduction

Malaria, Japanese B Encephalitis and Meioldoxis in --heSoviet Union, China and Vietnam obtained from publicationsdated I January 1964 to date.

Our Dearches. concentrated on resistance to therapy,drug reaitant forms, incidence, clinical treatment andcha therapeutio. of the diseases. Although primury stressin,6 malaria search was on Paloiparum malaria, there wasso little material obtained that it was thought necessary toinclude items of peripheral interest for their potential

value.,A MEMARS search for references on mellodole yieldedno Soviet-bloc material. An a safeguard, a further searchwith no restrictions on area or language turned up the

brief bibliography given in the appendix. In the otherbibliographies items in Russian or Chinese or those of poten-tial primary interest are indioated by a check (v).

Appended are bibliographies obtained by a MEARSsearch in response to an ATD request.

I II It. II II I

I II I

I. MALARIA I

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q

• *AUTHOR: CHANG Chi-ming (1728/4948/6900,HUANG Ch'wtui-jung (7806/2504128371

WANG Te-ming (3760/1795/2494,CHANG Po-chti (1728/0!30/079I-ING Hsien (0002/200s)HSI Wei-nien (1153/0251/1628)

ORG: Yen-chleng Special District Public Health and Epidemic te-_vontion Station, Kiangsu Provinet

TITLE: "Observation of the Effect of Pyrimethaminum and Sulfadia-zinum on Tertian Malaria"

SOURCE: Peking, Chung-hua Nei-k'o- Tsa-chih (Chinese Journal ofInternal Medicine), Vol 12, No 5, May 64, pp 425-426

ABSTRACT: Pyrimethaminum is ,he most popular antimalaria drug inChina in recent years, In 1959, Hurly reported that Sulfadiazinum hasan obvious effect of improving the action of 'his drug; therefore, *h,authors conduct a study with the method of combining the two drugs.The area of experimentation was a simple tertian malaria region, andthe 171 cases were all verified by blood examinations. The patients weredivided into 6 groups.

AUTHOR: CHOU Hsueh-chang (0719/1331/4545)

CHANG Tsu-sheng (1728/4371/5110)

ORG: Chia-hsing Center for the Prevention and Treatment of Schistosomiasis

TITLE: 'tIlinical Analysis of 56 Cases of Severe Attacks of Malaria, and AStudy of Its Treatment"

SOURCE: Peking, Chung-hua Nei-k'o- Tsa-chih (Chinese Journal of In-ternal Medicine), Vol 12, No 5, May 64, pp 418-422

ABSTRACT: Attacks of subertian malaria or maligrint malaria arecritical clinical expressions caused by the malaria protozons. I he at-tacks may be induced by a cold, over fatigue, over eating, or otherdiseases. The symptoms are not typical and may last one to three daysuntil the patient falls into a coma. If malaria is not positively identified

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in the blood, the symptoms may lead to a diagnosis of upper respiratoryinfection, septicemla, typhus, or acute schistosomiahis, and the treat-

rnent will he unduly delayed. This paper revlew the variouS differentsymptoms observed by the autho, in the 56 vA hnu .h mpiti!ihm_ front-July, 1162, to October, 1963,

AUTHOR: CHU Chen-tung (2812/7201/2839)

ORG: Kuei-yang Municipal Firoit People's Hospital

TITLE: "Clinical Symptoms in 31 Cases of Malignant Malaria"

SOURCE: Peking, Chung-hua Nei-ko- Tsa-chih (Chinese Journal of In-ternal Medicine), Vol 12, No. 5, May 64, pp 415-417

ABSTRACT: The clinical expressions of malignant malari; are rathercomplicated. The toxic symptoms are extremely severe, and thesesymptoms may occur at any time. Fomn 1951 to 1961, a total of 115cases were verified to be milignant malaria in Kuei-yang First People'sHospital through blood or bone marrow tests. The toxic symptoms ofthese cases were analyzed in the pAper.

AUTHOR: FANG, Jul-ying 42465/3843/5391; Pien, Ju-Ilen (0593/1172/3425); Yang, Pao-chu (2799/1405/37961

ORG: Pharmacology Teaching and Research Section, Chekiang MedicalUniversity, Hangchow (Che-chiang i k'o ta hsueh Yao Ii hsueh chiao yentsu, Hang-chou)

TITLE: Screening test of anti-Japanese 1 encephalitis virus drugs

SOURCE: Yao hsueh hsueh pao (Acta pharmaceutica sinica), v. 11,

no. 6, 1964, 375-381

TOPIC TAGS: encephalitis, chemotherapy, drug effect, virus

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1,

Al

ABSTRACT: Out nf forty-neven kinda of druga oxprirn nallytested in mice infected with Japanese B encephalitis virus, 9 we- eshown to posscnx certain therapeutic effects; they are phenelzine,fAtmA11in, 8-miaguanin. thinnmicarb2~de, prnpadrlne, deoxyephe-drine, phenylhydrazine0 isonicotinylhydrazide, 6- MP. Of particularinterest was the observatitin that phenelzine and funacillin inhibited the"u iLitlication of Japanese B encephalitis virus in mouse brain, Byanalyzing the relationship between chemical structures and therapeu-t t! fsiftins ! fuch effeetivo-~stne ai hyd-razine benz .i coftotd-_*

cyclo semicarbazide, ephedrine analogucs, anti-purine compounds, itto reasonably expected that those compounds may be used as tools forfurther studies to throw additional light on the chernotherapputic rnecha..nimn of action against Japanese B encephalitis virus. The authors ex-press thanks to Prof. CHU Heng-pi (2612/18543880) for reading themanuscript. Orig. art. had: 4 tables. [FDD]

AUTHOR: HOCh'i (0149/3823)

ORG: Institute of Parasitology, Chinese Academy of Medical Sciences

TITLE: "Chinese Studies on Malaria"

SOURCE: Peking, ChxN-hua Nei-k'o- Tsa-rhih (Chinese Journalof Intern.-l Medicine), Vol 12, No 5. May 64, pp 466-468

ABSTRACT: This paper rcviews the accomplishments in malariastudies in China since the inclusion of the elimination of the fiveparasites of China in an Outline for National Development of Agri-culture (draft) by the party and the central government in 1956.The major achievements discussed in the paper include: 1. The studyconcerning the division of malaria regions and the respective controlpolicy of each region; 2. The study on permanent curp for tertianmalaria; 3, The study on mediums and carriers of malaria.

II

AUTHOR: 1W) Ch'i (0149/3823)HUANG 'en-hsun (7806/24?9/3168)1ISUEH Ai-Tseng (5641/1947/2582)CTIU Fu-yao (2612/4395/5U691IU Yin-lung (104.41/069""o_,.1,/.0W9-2%

YANG Ch'ing-chang (2799/1987/3864)

CTAING Ching-rhih (172P/2529/25351rt Yun-fang (0265/1301/5364)

ORG. Ha, Hohng, Hsueh, Chu, I.u of Inmtute of Patr-ttisrn, Chine eAcademy of Medical Sciences; Yang, Chang, Fu of Shanghai MunicipalCenter for the Prevention an "4 Control of Schistosomiasis

TITLE: "Cure of Tertiary Malaria in Children with 210 mg, I40 mg,and 120 mg of Primaquine Du'ing Latency"

SOURCE: Peking, Chung-hua Nei-k'o- rsa-chih (Chinese Journal ofInternal Medicine), Vol 12, No. 5, May 64, pp 407-410

ABSTRACT: Tertiary malaria has a wide distribution, and its clirnna-tion is an important problem. In foreign countries, the method of smalldoses and long duration of treatment is generally used for tertiarymalaria. This method is not very effective for the tertiary malaria ofthe Southwest Pacific area, however, the rate of recurrence is as highas 30%. From October, 1951, to May, 1962, during a period of latency,a study was conducted with 210 mg of primaquine (divided into 7 days),180 ng (dividei into 80 days), and 120 mg (divided into 4 days). Othermethods were uied as control. The result showed that this method isthe most satisfactory for tertiary malaria in children,

AUTHOR: IISIEH Shu-chen (6200/3219/62971WANG Chia-hui (3769/0857/3843)HU Mei-sai (5170/7796/6357)WENG Hsin-hua (5040/1800/5478)TI Chih-p'ing (5049/3112/1627)TAI Tzu-ying (2071/5261/5391)

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9

, , • .. . . -,; ... • : .... :.. . . .- " ....... "7 "- .

F>F 7 ORG: Hsieh, Wang, Hu, Tai of Teaching and Research Group of Con-

tagiois D 3eases, Shanghai First College of Medicine; Ti, reachingand Research Group of Psychiatry, Shanghai First College of Medicine

TITLE: Certain Special Clinical Expressions of Tertiary Malaria

SOURCE: Peking, Chung-hua Nei-k'o- Tsa-chih (Chinese Journal ofInternal Medicine), Vol 12, No 5, May 64, pp 411-414

ABSTRACT: Certain special clinical expressions such as coma, jaun-

dice, and abdominal pain are frequently rrported in malignant malaria,but seldom mentioned in tertiary rmalaria. Of the clinical data for ter-tiary malaria in the hospital of Shanghai First College of Medicine,there are some obvious symptoms of central nervous system, liver,lung, and kidney involvement. These symptoms, if not understood,may lead to mistakes in diagnosis. This paper reports these symptomsobserved in 329 cases of adult tertiary malaria from January, 1958, toOctober, 1V-63.

AUTHOR: YANG, Ch'ing-chang (2799/1987/38641CM! Shih-iung (2621/1193/2837)TSENG Sung-k'un (2582/2646/0981)FU Yun-fang (0265/7301/5364)WANG Jen-chen (3076/0088/3791)HSU Ts'ui-fen (6079/5050/5358)

ORG: All of Shanghai Municipal Center for the Prevention and Treat-ment of Schistosomiasis

TITLE: A Preliminary Observation of the Effect of Cyclochin onTertian Malaria in Shanghai

SOURCE: Peking, Chung-hua Nei-k'o Tsa-chih (Chinese Journal ofInternal. Medicine), Vol 12, No 5, May 64, pp 423-424

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m Im;

ABSTRACT: Cyclochin is the 4-choroquinum type antimalaria drug.It is not as easily accumulated as atebrin. Cyclochin is currently oneof the common drugs for malaria in the Soviet Union. Its synthesis wasaccomplished by Shanghai Chung-hsi Pharmaceutical Plant in 1962. Forthe purpose of clarifying its effects as an antimalaria drug, the authorstreated 34 children with tertian malaria in latency. Follow-ups in 10weeks after the treatment was completed revealed protozons in 93. 9%of the cases, but none of the patients developed malaria symptom dur-ing the period observed.

AUTHOR: None

ORG: None

TITLE: "Current Studies on Malaria"

SOURCE: Peking, Chung-hua Nei-k'o- Tsa-chih (Chinese Journal ofInternal Medicine), Vol 12, No 5, May 64, pp 405-406

ABSTRACT: Great advancements have been made in studies on malariain recent years. Through extensive surveys and large scale experimen-tation, the regional distribution of malaria is basically clarified. Thespecies of mosquitoes, their ecological habits, and their relation to theprevalence of malaria are better understood. For the purpose ofthorough elimination of malaria, the following key problems are listedin the paper as being in need of concentrated effort: 1. A permanentcure for tertiary malaria must be found. 2. The techniques of fluorescentantibody tracing and others, reported in foreign countries for determiningthe malaria antibody in the blood of inhabitants of an epidemic area,should be introduced and developed in this country. 3. Although chloro-quinum, cyclochloroguanidum, pyrimethaminum, and primaquinum areall being mass produced in China and have become common antimalariadrugs, each has its defects and none is ideal. A more effective andsafer drug remains an important problem for future study.

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-.A2at-L-

1-~F;

-~

* II. JAPANESE B ENCEPHALITIS

II,

-9-

STUDIES ONi THE PLAQUE-P ORMIN0 CHARACTERISTICS OF THREE STRAINSOF JAPA UISE B I"Cl.PI[ALITIS VIHUS

CI,'en Po-ch'uan (711,/01J0/.8), 1Iru Chao-haiang (4070/0$40/4382), and Liu Yuan-yluan (2692/0 /0337). Wci #hang wuhoueh pao (Acta ,microbioZogida einioa), i,. 10, no. , 19#4,333-3.38.

The difference between plaque-forming titer and the mouse-brain LD50 titer, the plaque-forming rate, the rate ofdevelopment of plaque, and the distribution of differentplaque sizes of 3 strains (the A2 strain, the chick embryoadapted A2 strain and the Nakayama strain) of J. B. E. viruswere studied. Concerning the rate of development in numberand in size of the plaques formed by these strains duringincubation, it was seen that the rate was evidently greaterin A2 strain than those observed in the other two. Finally,the possible reasons for the differences in p aque-formingcharacteristics and the relation of the plaque sizes tocertain biological properties of these strains of J. B. E.virus, especially in respect to A2 strain and the chick embryoadapted A2 strain, were discussed.

ASSOCIATIONJ: Chung-kuo i hsueh k'o hsueh yuan Ping tu hsuehyen chiu so (Virology institute, Chinese academy of medicalsciences) [CR]

INTERFERON FORMATION IN CHICK EMBRYO

IXvanova, N. A. Znterferon formation conditions in a chickembryo fi.brob at tissue cuZtuare infected uith Japan.. Bnoepha',tis virus. BSyuZleten' eksperimentaZ'noy bioZogi i

: ~maditfsinyl, no. S. 1986, ? '?

Only biologically active lauanese B encephalitis virus in-duced interferon formation in a chic embryo fibroblasttissue culture monolayer. Interferon formed in infected.hick ftibroblast ells quickly passed into the surrounding

1.0

-10-_14

_ _ _ _ !

. = -

II

.Z

fidi sodium and did not accumulate in the call,. Largedoses of heat-Inactivated virus did not induce interferon

* feraation in the cells. Preliminary Interferon treatmentof tiseue culture before infection decreased rather than

lw t14reaaso fretsh interferon production.

EXPERIMENTAL STUDIES ON ACTIVE IMMUIIIZATION AGAINST JAPANESE BENCEPHALITIS; I1. THE RELATION BETWEEN THE INDEX OF PROTECTIONIN MICE AND THE ROUTE OF CHALLENGE

Hsu Chao-heiang (60?9/030/,382)I. Chou Ming-hea n (0719124/940341), and Ch'en Li-t. Vi aheng wu hauch pao (Acta mioro-

C biologiva sinioa), v. 20, no Is 1964, 9-1C.

In an attempt to explore the mechanism of immunization ofthe activated encephalitis B vaccine, the authors comparedthe protective effects of Immunization by brain and subcu-taneous inoculation, The rolatior.ship between protectiveaction and antibody level was also studied. It wras found thatmice immunized only once acquired no or only a very weak pro-tection against virus attack through the brain, but verystrong protection against subcutaneous attack. Furthermore,protection against small amountb of subcutaneous virus wasobserved one or two days after immunization. Mice immunizedtwice acquired a very high protection against subcutaneousattack, and also sore protection against brain attack. Theprotective index was related not only to the amount ofvaccine, but also to the Interval of injections. In general,lower protection was obtained by injection at shorter in-tervals than by injection at longer intervals. Protectionby immunization persl.sted for a short time only, even thoughneutralizing antibodies in 'he blood *trecn persisted longer.The relation between the index of protection and the routeof infection was also discussed,

ASSOCIATION: Chung-kuo I hsueh k'o hsueh yuan Ping tu hsuehhsi (Virology department, Chinese academy of medical sciences)

(CR)

- 11 -

mm m m m mm- m m

STUDIES ON THE VARIATION OF PERIPHERAL PATHOGENJICITY OPJAPAmS B ENCEPHALITIS IN WHITE MICE

Huiang Chen-heiang (780614394/14382). Wei ehepiq wu houeh pao

Variation in the toxicity of Japancso Ls encephalitis virusWaa studied in mice of' dif'ferent ages. tioth intracerebraland subcutaneous inoculation were usedo with virus materialin all cases taken frocm Lhu br'ain. The virulence of virussubcultured irtracerebrally decreases over successive genera-tions when injected subcutaneously. Conversely, subcutaneous-vi-rulence does-not decrease when transmission is by the sub-cutaneous route. Strains with already l~~i~lcregain their virulence when once again transmitted subou-taneously. The incubation period and variation In thedecrease of subcutaneous virulence in successive generationsof virus transmitted via the intracerebral route were re-lated to age, incubation periods being longer and variationsmaller in young mice. It wa.. concluded that there arethree stages In virus virulence of cerebrally transmittedstrains, a latent period, In which progressive decreasein virulence occurs, and ,k static period, during which thedecrease in virulence becomes stabilized.

ASSOCIAT.iION: Chung-kuo i haueh k1o hsueh yuan Ping tu hauehhsi (Virology department, Chin~ese academy of medical scie nces)

(CRJ

STU~DIES 011 INFECTIOUS RIBCtJUCLEIC ACID OF JAPANESE B ECEPHALITIS VIRLX;IV, THE~ EFFELMS OF 7HEl VIRUS WIM]I INFECTE RIBONUPCLEIC ACID ONI BRALINTISSUE RIBMUCrEASE ACT'IVITY IN THE-' MDUSE

Liu Yuan-jiuan (2692/0337/033 7), and Liu Rua-ch'en (26921636312525).Wei elteng tou houch pao (Acta microbiologica ainica), v. 10, no. 1, 1964.24-30.

M.ice were Infected with B encephalitis viruses w! L n infective ribontucleicacid, and observations on the changes In ribcrluclea3e activity in braintissues were made. Ribonuclease activity in the brain tissues of' In-

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Tt "

feted mice first incroa-ed and then decieased. Injection of virusribcucleic acid or a larg mount of virus material resulted in a morervpid increase in ribonucleazc activity. Inoculatioti of sQl] amountsor viru se caused a slcy4 Insrease. When the mutiplinaticm. of viruLesin the infected mou.c brr.ln reached a c*rtan Cc ee, ribcmucleaneartivity started to dectrie,. As virus concntratlon in th braln in-creased, ribcnuclease activity continued to decreaue until death, bywich tine it had fallen below the normal level. If a very small amountor sublethal dose of infective material was inoculated, some or allaniml reeermd eaily within a choit tir and rlb' cl~aze activityin the brain tissues retun d to normal. On the basis of the experi-aental data, it is believed that the Increase in ribonuclease activityin infected brain tissues may be the result of preliminary resistantaction of cells against the infection. The decrease of ribonucleaseactivity in the later stages was probably due to intoxication anmimpairment of tissue mechanisms by the virus. The relationship betweenthe formation of ribonuclease in cells and the low infectivity in virusribonucleic acid was discussed.

ASSOCIATION: Chung-kuo I hsueh k'o hsueh yuan Ping tu hsi (Virologydepartment, iinease acaderry of medical sciences) LCR]

PRODUCTION OF AN INTERPRION-LIKE SUBSTANCE FRO CHICK EMBRYO

CELL CULTURES INFECTED WITH JAPANESE H ENCEPHALITIS VIRUS

Mao Chiang-80n (302913008/2773), Yang Ch'ang-shou (2635/7022/108). and Huang Chan-hoiang (7806/4394/4382). Wei *heng ,wuhsueh pao (Aota microbioZogiua ainica), v. 10, no. 3. 2964,339-343.

An Interfering substance with properties similar to interferonwas demonstrated in Japanese B Encephalitis virus-infectedchick embryo cell cultures. The titer of this substance, asestimated according to the plaque inhibition method withWEE as a challenge virus, varied from 1:32 to 1:128. Thedynamics of its production from the infected cell cultureswas studied. The results indicated that the maximum inhibi-tory activity was observed in the cell culture fluid at48-72 hours after virus inoculation, which was later thanthe maximum titer of virus multiplication. The maintenance

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level of the inhibitinig substance in the infected cell was

found to be related to the amount of virus inoculated, After

the maximum titer of substance had been attained, somelowering or the level was observed when large dooe@ pf the

virus were inoculated, while it showed no marked decreasefor a period of 5 days when small inoculum was used. A

comparison of the production of this substance between high

(Poking strain) and low (Nakayama strain) peripheral patho-

genic strains in cell culttures showed no difference in

titer.

ASSOCIATION: Chung-kuo i hsueh k'o hsueh yuan Ping tu haueh

yen chiu so (Virology institute, Chinese academy of medical

sciencos) [)CR

DYNAMICS OF IW FIi"ON PFeDUC''ION IN CHICK DIBRYO CELL CULTURE I*T

WITH INlEC'fVEI RIA OF JAPANESE B E24CEPHPLITIS VIRUS

Mao Caiang-sen (3029/3066/2773), and Huang c6e.-heiang (7806/4394/4J82).

Wei 6eelg wu hsuch pao (Mcta m.'crobiologica eintca), v. 11, no. 3, 19,85,326-329.

Infective RNA of Japantese B encephalitis virus, Peking strain, wasextracted from infectvc muse brain sus[enslaon by the cold phenolmethod. DYrn .c. or interferon production and virus multiplication InclLick e0'ryo cell culturv after infecticn with inrective vira RNA werc=rared wi.Jth th?:,:e infcctud wIth ccr~petc vlrur. The results indicatethat the interferon production in the viral RNA infected group was alwaylower and appeared 24 hours later than those infected with cc~letevir. during 120 hours observaticn. This difference holds true even whenthc infective dose of viral RNA used is I log higher than that ofcomplete virus. No difference in the virus multiplication curve patternwas found between the 2 grvtqs. A possible explanation of the abovepenomenon was discussed.

ASSOCIATION: Chung-kuo i hsueh k'o hsueh yan Ping tu hsueh yen chiuSO (Virology institute, Cinese academy of medical sciences) [CRI

144

...........

L II

ZJIKANCENT Or JAPANESE 0 ENCEP1HALITIS VIRUS TXTZR

Nao, Chiang-.en, and lnuang, Ch en-hoiang, Enhanaement ofthe virus titer of Japanese enoephaZiti uirus popagated(Aota wiarobiotogioa .inio), t. 12, no, 1, 1966, 24-2#.

Japu eoe 2 encephalitie virus when grown in D20-trvatedcells vat found to have a higher titer than t control.T The difference vts found to b gr~ater in the het-labileIakayama strain than the more heat-stable Peking strain.

ELECTRON IICROSCOPIC STUDIES ON JAPAMLSE B LNCEFIIALITIS IN

TISSUE CULTURE CELLS

PlagPI Ch'i-fang (789410360124.55), anad Chang Li-pi W1281440911880). We eheng uu hauoh pao (Adta mi robioZogica sinica),ii. 10, no. 3, 1964, 294-302.

This paper reports electron microscopic observations con-cerning the development of JEV in chick embryo fibroblastsand hamster kidney cello. In the early stage of the infec-tion, "dark cells" (cells with marked metabolic activities)appeared among the "bright cells" (cells with less metabolicactivity). One of the most distinct changes of the infectedcells in the moderate, and advanced stages was the formationof "multiple vesicles" in all parts of the cytoplasm, accom-panied by the appearance of JEV. The development of JEVcould be seen in almost all parts, especially in the vacuoles

I and matrix substance of the cytoplasm, but not in the nucleus.- J-EV measured approximately 26-32mu in diameter and appeared

round in shape. No intracellular crystal formation could be'K found in the authors' studies. The release of JEV from the

cells was found to be mainly through the vacuoles, whichusually contained large numbers of virus particles. Therelationship between JEV and the vesicles was discussed.

A$SOCIATION: Chung-kuo i hsueh k'o hsueh yuan Ping tu hsuehyen chiu so (Virolocy institute, Chinese academy of medicalsciences) [CHI

- 15-

__ __ - . m.es ar. mmm m m• .• •m m

COUCa~'rED CAMP~AIGN AM~IT JAPANESEk ENCEPHALITIS IN "hE PRiII'O)KIY KI{AY

whaste~kov, V. I., A. 1. Mikhecaa, I. N. Ple1Io*a, and V. S. Dorokho'alhurnn ~k i7~i,~i rooi v mmb .n oogii, no. 5, lot( 8-7f.

Art in1.cnnivc~ ownpoign ut ,P.Innt endierir Jatp~ir-m vcephalitir. iii the~

vec.to.As and protection of thc- pec~ple frnm nsecit bites has5 beeii In~ pro-gress since 1960, Thie tables aihcv results of atttmptn to elliitr WIn-

~ktt T -prAvikg thtvir breetding plaeo with chemc1ts. Sprkyllng litekrly spring produccd the' best reuls Msquito vectore of J(Lpaecse en-,cephulltlt in thic re~gion atre: C. trttaaiorhynchu4 G.. C. bitaenio'hmpihwC., V. pipiens L., A. trOgo! ad A. eaoocis, dam. Diethyltoluw Ilde wasthe mrOt effective.' riquitu rcpvllvnt.

Tablec 1. Results of trea~ting tetreacrvairs with ai DDT tuerosol

O~14

0 016 5 7u~ W)U 3

10 0.8 2-3 to 9-1,06

Thbbe 2. Results of tre'istin& a testre!nezvoir with 105 ITT dust.

Tin(of tai~l5 kill Tii,;e in

a2 Ito).

20 - 0,! 213 ol 0o 12 1-4/a40-UA ) 0 2.1 1 72'10 I.o- C4 17 4-W.-7U' 0: ~21 PO3 - 'AJ 100 ".M-05 I

10 ,-2 2 1 1010 iSA

-16-

: Table 3. ResijIt of oproying biotopes with a 2% aqueoliosolution of DDT pute

Time Nu. fdrop,/c 2 of au'e

t 0 "i- I n tiIri r -n

Incn Yffect of tretta~zt Ont-tremoe

= .pnzpar.l- 1

" 2-S Lai,'~ Idlirr (iii % )............hAX) (rw t'I K) I(0

KtL d (in ,) . .... -70 20 A .

____,__-Siirvii (in %).j II 3 i. ~JC

tact LF7 IIcn"ct i1

ur '~c~1 1 (in ... 160 1.. . . .(*. u f7,

AUTIIOI:I Shestako#, V. 1.; Iikheyeva, A. I.

ORCa Vladivostok Scientilc Research 2nitute o7 Ep3nemiology. Micro-

biology, eind Hfygiene (Vladivoetokskiy nIuchno-issldovat '5kiy insti-

tvt *pi-desto.2ogit, *ikrobiolo;:L: £ giglyany); PriLmarakiy Kray Regional

aanitary-Epidesiolosical Station (Primotekays krayeveye sanspidatants-

Lye)

TITLE: Study of Japanese iencephalitis carriesm in the Primorskiy Eray(1Ktitmi f Territory)

SOURC ,! ?edtask lg perasitoloiyAe I paraItarnyye boleuni, v. 35.

no. 50 1966, 54:5-550

TOPIC TACSI disaso vectors animal disease, osquito, virus disease,

encephalit is

biSTACTI ae H sne trenty mosquito species veto identified in JapaneseeScephalitis foci in the Pruorskiy Kray (both coastal and seador

reAons) in 1957-961. The potential vectors of Japanese eacephaltis

-17 1

a ong the identified species wore: C ex pipene (SZ of mosquito Io 06tion). C. bitasiorhynoahua (1), C. taeniorhy he (0.52)0 A. togo(78%). A. koroeiou (12), and A. ecoensie (22). The population of

C. tritoenorhynchus, the chief vector of Japanese encephalitis inmeadow foci, hae decreased 30-40 times in recent year* due to slimins-:ion of rice fields. In the coastal area, the chief species attackingman was A. togoi, and in fishing village, A. togoi and Cutex pipene, HIn the meadow areas the following species commovily attacked mant A.doroalie, A. vexone nipponi, A, euoeneao, Anophoele hyroanue, and some-:ti s Csuteeta seilvatria amuranss. Effective mosquico control con-sisted of treating panda with insecticide# (Co~sl rogiont) and *trial-sprayink (meadow foci). Orig. art. hast I table and 2 figures.

Shettako, V. I., and I. N. Polenova. Wintering pZaoeaof bloodeuoking moequitoes in Japanese enoephatitis fooiin Primorskiy kray. Zoologioheekiy shurnaZ, v. 44, no. 12,1966, 1871-1873. AP7001071

Winterino places of adult Cadet and Anophe e mosquitoesin Japanese encephalitis foci in the southern Prl.orokLykray were studied in 1962-1963. Vegetable storebouses,inspection wells of water supply lines, caves, collars,etc., with humidity levels of 80-100%, were most oftenchosen. Mosquitoes were found in hill *ites 150 a abovetheir breeding places. Mass flight of Cuaex mosquitoesto wintering sites occurred in late September--early Octo-ber (mean temperature 9-16C). Memo temperature i thewintering places rarely dropped below 0C. In the springAnopheea hyroanue mosquitoes left the wintering sitesfirst, In March. CuZde modeetuo and Cute: pipione mosqui-toes became active somewhat later, when the temperatureinside the wintering places roached 8-10*C. Most uosqui-toes had left the sites by late May--early June. Tiefollowing species of mosquitoes were found in the winter-ing places: Cutex pipiene pipiene (up to 902 of popula-tion), C. va an*, C. modeetue, C. apioaZie, C. oriontatis,C. bitaeniorhynohue, and Anophesee hyroanue.

UDC: 595.771 Culicidaa:616.988.25-022,957(571.63)

. I18

SVJ~iF 'HE fl 1 MAXION 1EtP ~FML2U-,'7 Tr, E"PA' CV lA 'IVAT4 Or'JAPANF B ENCEPHIALITIS VIRUS AND 7T, PROJG'flON OF ThRWUMO

Wang~ Shu-ahwng (3?G9/PPab/La 26, and fiua~'iq Chon-hiant (?80614394/4382).Wei xhenL7 wu haun4h pao (At.miro'biotoicca siniiea), v. 10, no. 3, V1,

This paper dealr with tr~c studitu3 of' dilfferent rK-hads and de;,x're ofS ~~~~Inactivatichr of Jaj-tiese B enicephJallt!ls virui, Pel'lrng ir~In, (41 IT

feron production. StUdicS on the abili~ty of differe nt dapr, of heatJnactivated virus to intcrfcrco wtn the hornologous virus mutiplicationalso shcr.-id that cr. i nactivati.'n of virus did not interfer'e withvirus nwUtip1icaiAon nor wf'th the product-on of interferon. 7MbStuther confixros the fact that conp)1cte Inactivation cl* virus causedit to loze its powerr to elicit Interferon pindcution.

fThe fact that interferan I:, heat stable wid Jappanese B3 encephalit'svirus can be crrvzltely inact4 vated a. 56'C f'or 1 5-60) :nin, togethur withthe finding that ccipletely inactivated mnateri al does not influence thevim-, multiplication r nor interferon prodUCt~on,--u4,_Pst that such asirp]e method as inactivation may be preferable to the acid dialyr-,smrthod usually cuployed for this purpose.

"~OCIATIOYi: O-izgkuo I hsueh k'o hMuch yuan Ping~ tu hisueh yen chiuso (Virology institut~e, Cninese acaderrV' of inwdjcal sciences) [CR)

EFFECT OF HIBERNATION ONI q1E MtJU1E OF JAPANF.SE 1; ENCEPHALITIS VIRUINFECIIO1 114 GROUND SQUIRMES

Wang, Yor-kuei (.3769/'O056/C311). Wvci 16he2n3 wu hinuch pao (Aota Inlc?.O-

T1hese experi! ents were carr'ied( out du.ring winter i brnjatinjg [,pound squirrel~s, Citcll-us rnconolicins ra'ncaus Thc-rnas.Lethal do.3es of J~parncsoc neepha~itis virus (Nakar'Dn Strain) wereinoculated inlto the brain Of Soundly torpid squirrels and observationsmade during and after hibernation. None of thp squirrels exhibited sipmof illness and ro deaths could be attrdbuttijj~ e t-o the virus it-fectioz1

-19-

dw,l1g 59 days of h1bernation. Vitus va". founc in the brain of indi-vidual squirrels fromr the seventh to t!he 44th day, and thc IW50 titers(in mice er 0.03 ml Intracerebrally) of the virus varied between 10- 2 37zw u .... -, No virus was isol~ted frcn the liver or spleen: Afterthe squirixv]s we, brxnqbt to ro temperature from the cold cabineton the seventh to 59th dav. 1prilrvls zucci znbcd after CMn to threedays. Japanese B encephalitis vlrms was Isolated from the brain ofthe;e squirre]s and LD50 reached values of In 6 . 25 to 10-8 ; 25. Noviruws was izolated frcii the liver and spleen.

ASSOCIATION: Shan-hsl i hsueh yuan Wei sheng wu hsueh chiso yen tsu(OlcroAbology re zh and teaching section, Shansi medics1 college)

JAPAI LSE B DICEPRAITIS V/A2CIFl. PREPAF.;D PHG. IONOLAYER TISSI., CtlJ",TUE;I. VIRUS CULTIVATION AND VACCIN@E P PARATION

'.mvig Yung-chi (07G/3918/2813), Ch u Nine-'hen (0719/1380/3791), Ku P'ei-

Lei (357/367107602,,), S.w 1jon (1327/06.1i7), .&L Wc;-hs{,j (7456/2429/0207),Sw; : - o (1w2/ 1 1/ 3 6 , :d L-" !.'Ci-jUn.g 02 116019113] 69). Wei.

,io :wi poo t rcrbiolOglr, v. 10, rin. 1, 1904. 31-38.

In 1958, te pe.: ration of a B encerP. i izs vaecicin ;;- begun usir..- chickentryo cells as a culture medim . By 1960, a considerable amount ofencephalitis vaccine had been prepared and had begun to be used as aprophylactic agent for encephalitis in man. The authors Investigatedvirus cultue and preparation of vaccinc. Both chick embryo and mousebrain strain of B encephalitis virus multiplied easily on single-layerchick embr-yo cells and could be serially passaged for many generations.The toxicity (LD5 0) of srially passaged viruses did not Increase. The&owth curve pattevn of various strains of the virus ias studied andfound to be identical with a maximum titer (LDS5) ranging from 10- 5.0to 10- 6 . 0. Parallel titrations of the virus content both in Infected cellsand in the corresponding maintenance fluids gave comparable LD Otiters, A culture mediim containitig seven amino acids may be usea as asubstitute for t,:o, 199 culture redun in cuilturing the viruses of Bencephalitis. The toxicity of viruses obtained fro the two culturemedia was almost the same, but veried at different culture intervals.In the seven amino acids culture medium, it attained its M&XiaMzn con-centration al 48 hours or somewhat later after inoculation. In No. 199

- 20 -

4

culture ttcti.ri, h wever, it attained its miaxirum at about 36 hours. Forpreparing tissue culture vaccines, it is suepested to u-se mouse brainstntn or chick c'rbr/o strain as the parent strain, and to maintain theculti e tcmperntire of ct'Is and virus strains at 33-37C. When 0.1%fonnalin was added to the culture media, it vas activated within a short

....... ,tim.2 and maintained its antigensicity.

ASSDCIATION: Vei shonr pu Sh~ng wu chih p'in yen chiu so (Bioleziicalprodunts instltute, l1n1stry or public health) Wna Yung-chi, Ku P'ei-wei,Sun KLen, Chou Nirn-chen and Ii .ci-ju;rig; Chn'cn-tu sheng wu chih p'Anyen chiu so .Ch'eng-tu bio1c al prod,_ctt intitute) Ma Wn-hnAn, and

Sun Sheng-hao [mi1]

NWO CASES OF SUCCESS IN CHICK EMBRYO ISOLATION OF B ENCEPHA-

LITIS VIRWS FROM BLOOD

Wang Yung-ohi (3789/3938/2 813), and Li Mei-jung (8621,/6019/1359). Wei ahong wu houch pao (Aota miorob*o~ogica uinioc),v. 10, no. 1, 1964, 221-123.

Encephalitis viruses from the pathological materials ofB encephalitis patients were isolated using chick embryoand mice. Among twenty-one blood samples, there were twopositive cases. Two virus strains thus obtained were iso-lated successfully from the chick ermbryo but not from mice.Prom twenty-one spinal fluid samples, there was one posi-tive case, and there were two positive cases from threebrain tissue samples. All three positive cases were suc-cessfully isolated from the chick embryo and from the mouseand six virus strains obtained. The above eight virusstrains have been proved to be D enc,:,pralitis viruses bymeans of the neutralization test, thc complement fixationtest, and the blood coagulation inhirdting test.

ASSOCIATION: Wei sheng pu Sheng wu chih p'in yen chiu so(Biological products institute, Ministry of public health)

(CR)

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prLICICCSISI QEPCPT rl, A FATAL CASE iN a PPTY156 SrLUfFQ.4 prf Ap~pv wEIr ccps 10q'223-71 1963

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I V VE C TOR S

-27-

MOSQUITO FOOD SOURCES IN TlHE LAKr ZASAN--BLACK IRTYSII

DI'LTA AREA

A~uf,~id a, V. 17., and A. A. 91a , il. 'Itccv. Food souren of

hi~od e'eel:ir :o::q:itoec in a foc:.z, of AR,'"O viruD infections

in thc oftil:c- .t pa.t of tl: horc of Lakc Zaican: and in

thc bIlack" I'ty.': drlto ( a 't t a.. e tan ob'Z ct, Kazakh

bolc;;i, v. 36, no. 1, I.7T 2.-3. AP7007782

The food sources of bloodsucking mosquitoes were studiedin the summers of 1963 and 1964 in the Zaisan region ofEast Kzakhstanor. list by the standard methods of analyz-ing the blood in mosquito stomachs and using baited traps.The following species of mosquitoes were most coninon inthe area investigated: AnophZe hyricanus, A. maculipennis,Acdcs cacpiu, Ae. vexanzs, Ac. flavesceno, CuZex raodcstus,C. Pipicn , and Manonia richiardii. It was found that on

the shore of Lake Zaisan and in the Black Irtysh delta area(including nearby populat.:d areas), food sources for mos-quitoes were cattle, hors.s, sheep, goats, people, andbirds (chiefly migratory birds). Tests of the blood in626 mosquito stonachs using the precipitation reactionshov:cd that in uninhabited territory and around populatedareas in the Black Irtysh delta and floodplain, mosquitoesfed nore on wild birds (41Z) than on cattle (17%), horses(13Z), or humans (20%). In settletnents, the chief sourceof food wyas cattle (507). It is probable that the role ofbirds as mosquito hosts is even more important in %:ilder-ness areas. Use of traps containing muskrats or wild birdsshoved that the greatest nuimber and variety of bloodsuckingfem .cs were attracted to common pochards (Azuthya fcina),gadw l]s (Ar.ag ctrcpcra), red-necked grebes (Podiccps ri sei-gcnc), carrion crou:, (Corvus coronc), and moor buzzards(Circu. acrze'noc u). Tables with a detailed breakdoxin ofthe number of rosquitoes of each species in different areasor traps are provided. Traps fixed in the windows andchimneys of houses contained only Anophel.ec h.jrcanuc nos-quitoeo.:, although A. riaculipcnnis and Ac. caspius also areknown to invade houses in this area. The existence of anatural focus of APBO viruses (equine encephalitis group)in this area was established by the presence of antibodiesand viruses in the blood of six species of wild birds and

-28-

four spcci,: of bloodsucling mosquitoes, and by the demon-stration of parasitic connections between mosquitoes and anunber of wild bird species, humans , and agricultural ani-M.n1 s .

OI)C: 595.771--153+616.988.25-022.39](574.42)

0:G: Division of Insect Biology ard Ecology, EntoiologicalDupartent, ]istitute of Nedical Pnrasitolo-y and TropicalMedicinc In. Ye. I. Martsinovskiy, Mini stry of PublicEeItth SS!Si1., Moscow (Otdcleniye biologil. i ekolorii nase-komyl-h cnto:7oJ.o1ches.Logo otde3la Instituta ricditsinsl-oyparazitologii i tropicheskoy ncditsiny "linisterstva zdravo-okh1rva,',1iya SNSIQ); Oicpart;nz-t of Viroloiy, Kazakh Instituteof EpJde::io oly, ![3crol, iology, and ly-,icnn, Alrqa-Ata (Otdelvirlso3.ogii }'a;akhskogo ilitLi tuta epidmlo].ogii, Tliirobio-

:oSQUITO CONTROL IN CHINA

ro, Ch'i (0149/3823). Recent progreas in study of mosquitoor trol in China. Chung-uo k 'un ch'un:a hcuch hui crbh shih

c ;ou nien hsuch chu t'ao Zien hui hui k'an, 2966, 67-69.AT6030759

The author revIews the progress of studies made on mosquitocontrol in China since 1952, based on discussion at the

medical Insects Group. A total of 99 papers on medical in-sects were submitted, and only one paper, presented by Pro-fessor Li lBui-han (2621/6540/3352) of the Shautung MedicalCollege (Shan-tung i hsueh yuan), was on mosquito control.This indicated that studies on mosquito control had not beenadequate, although n nationvid, insect control prograr waswell underway. A 1960--1961 study by Li lui-han and SunWen-hsiu (1327/2429/0208) of the Shantung Province ParasiticDisease Control Institute (Shah-tung chli sheng ch'ung pingfang chili so) showed that Czic.. pipienn palZcna- in Tsou-hsicn, Shantung had been controlled with DDT and benzenehexachloride. Anophi.co r.inw tn was controlled in South China,particularly on llainan in 1963. Control of AnnphcZe hyra-

-29-

II

cair'tc cipicnoic and A,:aPhOICS ludlowii began in the Ch'ing-p' u County near Shanghai under the supervision of the EastChina Entoinology Institute (flua-tung k'un ch'ung yen chiuso) and in Uu.-hsing County, Chekiang, under the auspicesof the Parasitology Institute of the Chinese Academy ofMedical Sciences (Chung-kuo i hsueh k'o hsueh yuan Chishoag ch'urig ping yen chiu so). Preliminary results wereto be available at the end of 1966. Since paddy borers andAnophelcC species arc bred in rice fields, the author pro-poses that study must be made in order to develop an effec-tive etihod for sinultaneous control of both insects.

OkG: Medical Insect!; Group (I hsueh k'un ch'ung tsu) [PY]

r[I',3E2 ANu TICKS OP THE SUBTROPICAL ZOIE INJ ABKHAZ ASSR(ACARINA, TYROGLYPHOIDEA)

Xadzhalfa, C. Sh. IN: Akadainiifa nauk Gru:nskoy SSR.Soobhchceniya, v. 39, no. 1, 1965, 191-206.

Twenty-five species of Acarina and Tyroglyphoidea comprisingS451.1 of the species of the Georgian O.S!i and 20% of SSSR

fauna were found in the subtropical zone of Abkhaz ASSRduring a study conducted mainly in 1961-62. This pe'tpopulation is serious to ariculture and horticulture.

';T2.ec'cic re-1-tered in Abthaz "-SH are classified as follows:faniJ ; T:,r' o(:J.:bo~da1, 10 gci,.'a and 16 species; familySapr'o~;lyphotdae, 2 rcnera and 2 species; family Glycvphagidae,14 ienera and 7 npecies. They are divided Into 2 groupsaccordinq to their adaptation to snecific habitats: thesynanthropic forrm. include 13 snecies found mainly in rrainand seeds, tobacco, tea, nulbs, tubers, fruits, cellars ofstorehou:.es and tranaries, and in wet debris in storehouses,mills, and wine barrels. 5iThe field forrms include 12species found in natural surroundin.gs: forest floor, plantrefui;e, decomnpos n wood, leaves, and ant hills. Thesynanthronic population was heaviest where optimal moisture

- 30 -

conditions were maintained. T10u1, several thousands ofAleuroglyphus ovatus were found per 150-200 ml of flourresidues from a water-powered mill. Tne population densityof the field form depended on moisture conditions and onfood supply, hay stacks beinr most heavily infested.

ASSOCIATIOI: Akademiwa nauk, Gruzitnskoy S.3, Institutzooloirii (Academy, of Sciences, (leorgian S:R, Instituteof Zoology) CDP]

ZOOLOGICAL 1FACTORS IN Thl':I EXISTEtICE OF SEVERAL NATURALTULAREM1IA FOCI

Kuchcruk, V. V., I. L. Kulik, I. A. flikitina, P. A.Panteleuev, !. A. R!ubina, and P!. V. Tupikova. Zhurnalmikrobiolonii, epidtemiologii i imrun obiologii, no. 6,1365, 80-86.

A July 1956 outbreak of tularemia among water rats (Arvicolaterrestris L.) living along a brook in the Altai foothills(Krasnogorsk i4ayon) was described. Affected animals con-stituted 27% of the water rat population of the section ofthe brook where the epizootic occurred and 12% of the totalrat population of the brook. The vector was the Ixodestick which in its larval and nymphal stages parasitizedchiefly the adult animals. Water was a less common sourceof infection, for after removal of the sick rats, no otheranimals became diseased although the brook remained in-fected. The epizootic was confined to the summer, coinci-ding with the period of mass infestation of Ixodes nymphs.It was also concentrated within a small area. Epizootic-in the subalpine brook foci do not spread too far becausethe individual brook populations have little contact witheach other during the summer. All the tularemia foci ofthe floodplain and subalpine brook types studied shared thefollowinm characteristics: the water rat is the universalsource of infection, while Ixodes ticks serve as a reservoirof the pathogen during the periods between epizootics;

- 31 -

thc epizootics occur during periods of peak infestation bythe tick nymphs.

ASSOCIATIO0 ). Intitut opldeiide loii i mnikrobologii in.N. G'. Oa'alei A',If 3SRS (Oamaleya Institute of Epldemiologyand -licroblology A't. S SI ) [DPJ

EXflM IN ROCKY AREAS OF THE ILl RIVER BASIN

Isrimbekov, Zh. ff. IN: Akadera nauk Xazakhokoy 53R. Isves tia. no.3,"

J966, 71-76.

Mosquitoes are the main component of the blood-sucking insect population

of the Illi river basin. Collections were made from MaW to September

1963 as part of a larger study of virus-carrying insects. At the time

of the study no investigation for infection of mosquitoes was carried out

because the aim of the study was ecological rather than epidemiologicl

since little was known about species composition and habitat of these

insects in this area. ThL collection area was varied, with clear vertical

zonation In ecological areas ranging from desert to forest. Fourteeu

sppcfes and one subspecies were collected from heights between 2000 and

2700 m above sea level. The table shows results of collections. -

- -4

F Tabi. 1. Spreies Coipoiti-on and Fa&Uve Number ofP M~~"quitoes in &ooky Are"s of the Ili Ri~ver B~win

~ ~ ICatch data

AbsoluteILpce number Ne gor

L Female Waes fConcentra-*A,*~beles b1M7cely L, 1 - 0,02 17.Vl --

An. oweidiptaula Mg, 8 - CIS 21. V1 - 1.UCW4afaaasiAgnjis Ldl. 43 2 2,0 26.y - 41IX*A~do auspius Pal. 35 0,4 LVII - WNW1Ar. dokaa1ia Mg, 2716 Ito S0 0 JLB j0.V! -S.VilI l.IxA*. fl~vosetoes Mull. &D 5 2.6 10.V 2.VII-3OVIII 4.IXAt. totepji4 Dyar, 52 4 3.6 IS.V 4.VI -25.VI 24.V11At. 1111111260 Me. go a 2.0 16-v 1o.vi -10.V1 is. v uA*'. ialrudes Dyar. 182 - 6.2 IT..V 191V - S.V! 4.vIIA*. wzex v.'xans Mg. 14 1 0,4 4. VII - 14.VlJ.A#. vcxoxu x~nt hat i. 4 - 0.1 20. VI - 14.VWAd. taeren.l'g.I 1 2.3 ISV! V.Vl-jg.vl 16.VJi*Caltz SmWdnru, Pit, 32 2 O's 18.V - 4.1XC. eulis Dyar. -. 2 0.06 1&V LIXC piplans L 26 82 1.6 24.V1I - Lx

Total 2134 5 *~ 100 I I.V-40.VIu 7.ix

ASSOCIATION.- Iflstitt acologli AN KaZSS (Institute fZooy cdzOf Sciences Xa&eWkh SSE) ,/Oj q?-, OfZoloy P]adn

M4EDICAL INSECT CULTURE

Lu, Pao-Zit (7120/2405/??92). Chung-lcuo Jc'un tch'ung houehhui ei'h shih ohou nion hauch sh, '~ 'ao Zzfn hv~i hui P. 'an$1966* 50-52. AT60307 54

The author rcvi~cws the projpreso and discuGs major problemsin redical insect culture. rroblceis ancotintered In develop-pent of intact strainst in laboratories include difficulties

-33-

I

in tantin, And ovary development, overcome by Prof, No Ch'!(0149/3823) in fertilivation of Ch'tceue mosquitces (A. uinen-sin) by forced matint,; conditions for ovipocition, includingthe prevention of retordatiou in jro'wth and hatching by theuse of fer|'entc-d culture tedis to stimulate batChing by HuNent. (5170/5) 4) ili 19(3j and horiogencity of innect quality*with emph.u1. s on control of culture conditions aid popula-tion dcaultics to increase breeding efficiency. The author

urg.s oxtvii ive Ftudic! in order to keep atrevt of foreigndevelojr.!vt in innect culture. This paper was preparedduring discussion by the Insect Dionurica Croup on 14 July.

OIRG: InLect bionotiicu Group (K'uin ch'uiun RI , t'ai tuu)

(PYJ

CONTROL OF BITING IN%"'-CTS

Nirsayeva A, G. Conferenoe on the problem of oontrol ofbNoodsuoking insecto. AN $SSR. Sibirekoye otdeten~ie.Iutveetiyja. Seia biologo-meditsinskich naask, no. 2, 1061.II?.

Prom 25 to 28 January 1966 -a Les ng was held in Nov-. --

sibirek at the Biological Institute of the Siberian branchof the Soviet Academy of Sciences on control of bloodsuck-ing insects. One hundred and fifty representatives of 69organizations heard 42 papers. The conference emphasisedthe biological basis of control of these pests. A numberof papers were devoted to the ecology of bloodsucking in-sects in various regio:o of the Soviet Union, and relatedsubjects. It was noted that when cattle are massively in-fested with these pests, milk production declines by 11.52,and weight jain I* calves, by 34Z. The results of testingnow insecticides and repellents wore presented. The mosteffective was found to be diethyltoluamide. Cood resultswore also obtained with benalune. The use of protectiveclothing was diccusted, as was the application of aerosol&.Areas for further invastigution were pointed out, and, In

- 3-

J

-f: eclulsion, the follvtnu recommendations were made:developing the pro#uctiou of possible insocticidto, estab-l, ohim a ystet of taritorlal stations for pest control,

&ad fiarther study of the newest methods of controllingthese pests. z l]

.AUT11ORt Hodel' . Kh. X.; Mishayevs, N. P.

OIG, Belorussian Scientific Research Institute of Epidemiology and0 Microbiology, Minsk (Belorusckiy nauchno-ies1*&ovstel'skiy institut

epidemiologii I mikrobiologil)

TITLE: Studies of the fauna and ecology of bloodsucking mosquiLoes 4tAthe Gomel' obleat of the Byelorussian SSR

SOURCE: Hditsineskaya parauitologLya I parazitarnyye bolezni, v. 35,no. 5 1966, 607-609

TOPIC TAGS$ animal divease, disease vector, mosquito, population etudy

ABSTRACT:Twenty species of xosquitoes were identifiad in the Svetlo-Sorsk rayon, Including 18 bloodsucking species (subfamily Culioinae)belonging to the genera Anophal.., Aedos, Culex, and Theobabdia, andtvo non-bloodsucking species (subfamily Chaoborinae) belonging to thegenera Chacborus and Noahtony:. The most numerous and widespreadspeciea of bloodsucking mosquitoes were Aedes communia, Aede.. *oru-aians, Aedee punoter, and Aedes moutatul. The chief breeding placesfor Aedes mosquitoe were forest and meadow bogs, sinkholes, trenches,and ditches. The seasonal population of Aedeas mosquitoes (late Aprilto' early Septembew) varied depending on the biotope. The averagetumber of mosquitoes collected In 10 minutes was highest in areas ofnettle and Spiraea (easdovsveet, etc,) growths. Orft. art. has: I fig-tare. (W.A. 50)

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I I -n . I

1"QUITOES IN THE KRASNODAR REGION

Mooaov, V. A. Imeditinskaya pa.zcitoZoiya i paeazit.amyy* bolexn'tV. 35, no. 3, 1966, 3M1-372.

Ac-is ructicuc wns first observed In the Soviet Uain-i in the Krasnodarregion in 1956. Since then, after a cold winter, the insect aycearsJ"I the early spring and in most corn in 2jkty vcooded areas.

ASSOCIATICt: Krannodarskaya krayevaya sanepidstentsiya (KrasnodarRegional Health Station) . (LP]

AUTHOR: Morozov, V. A.

ORG: Krasnodar Region al Health Station (Krasnodarskaya kryevaya sanepidstantsliya)

TITle.: 4'squitoes in tne Krasnodar region

3O UGE: Meditinukuya parazitologiyu i puraziturnyye boleznk, v. 35, no. 3, 1966,3TI-372

TOPIC TAGS: Vecclog, insect, "', mosquito

Aedee ruatia' was first observed in the Soviet Unior. in the Kranodarregion in 1956. Since then, after a cold winter, the insect appearsin the early spring and is most comon in Ult3y wooded areas.

-36-

4. " ,

lt

SINULZOAN OF THE LOVER XAN RIVER

: Xuravljava, 7. V. SPii4lidua of thatowa 47i Riosi inthI ~ . i*'4toyarsk regten. KMditvinksata parazitologia i para-] 8a nsysv botavii, no. 1, 1g6, 15-1D.

LIn this area 25 species of simuliidae imagos and larvae: _ : were found. Duringf the entire sasonp 99#2% of adults

consisted of Fimulium gaZ.ratum*, S. moresitan Zongipalpe,Gnu# jaOviUaum and Gnus choZodkovski. The Kan River andthe Rybnaya, Its largest tributary, are the main breedingplaces of these bloodsucking black flies. Water temperatureis the most important factor determinine simuliidae speciescomposition in streams while current speed mainly infl-encee habitat distribution of larvae in the river. P.aZpestro# P. tridentatis, S. tongipalps, E. bioorne, and8. shouJakovi preferred stomy bottota areas with a tempera-ture no higher than 100C. Only one species, E. auveum,

Syam collected where current speed was less than 0.5 m/sec.

ASSOCIATION: Otdeleniye biologil i ekologil nasehomykhLnstituta meditainskoy paratitologii i tropicheskoy sieditsinyins. e. I. ,tertsinovskogo ?inisterstva zdravookhraneniya88SR, K.;qkya (Insect Biology and Ecology Section, Instituteof Medical Parasitology and Tropical Medicine, Ministryof Health BSSR) ([ //, 3.- [LP)

* )6=WOXQJSf U THE VICINITY OF NORILSK

PoJ lakovzz P. Ye. IN. Si buco. otdeteniye Akamuii nauk SSSR. IxVeatiya,

Data resulting from collections of flies made in 1963 in the vicinity ofNorilsk are sumarized in Table 1. As shown, the Talnakh comunity isdominated by A. 000m1lie and in Labytnanga, A. excrsaian A. pwotorend A. Axo=dotue predominate. As shown by Pip. 1 and 2, the mosquitopopulation reaches a eak in July and the mosquitoes themselves are mostactive during the night hours.

-37-

Table 1. Species composition and numerical relation of flien in thevicinity of Talnakh and Labytnaiga (according to data collected frca196o-964)_

........ .... "- - " ' " At eh . 'ea. _ _

' Talnakh LtAbytnw;V4tSpecies

Larvae Female4Males Larvacfemale Iales

Aedc; / Aadaiatas Dyar. 267 4510 so I6 2317 IsA. punclao Klrby. 26 17 1177, O3A. camntnani Deg, 2009 182 76 61 66A. p ltal.u Coq. I 38 2 12A. infuds Dyar. 1 2 4A. diUjuus R D. K. 69A. impftr Walk, 3 1 3A pionips Dyar. 19 2 2A: ciaeetus Ai 40 3 3 17 _A. excruciams Walk. 2 3 1 4316 19@9 24CuIIsoa afaskhaesls Ludl, 182 _1_122

Total . 2438 5184 139 7118 I &7142

A. nigripcs and C. bergrothi are not included in the table.

foor '° ! S,,o,4 g 00.

a , 7

* 0

+O Fig. 2. Daily activit¥ of moe-•

- I quitoe in the Talnakh and

June "ytnanga eFig. 1. Seasonal increase in numbera 1 - 3-minute count; 2 20-minuteof mosquitoes in the Norilsk area count.

1 - 3-minute count; 2 - 20-minutecount.

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NOAQUtTONS XN TOHSK OBLAST

P@lyd&ova P. Yo., and S. 1. Bobrova. Fauna and sootogy of

blood-sucking nosquitco (Diptera. Cut-0 ) inl the

e.E~no. 20, 1oss6 11-16573.

Twenty-threa opceii'* of uoequitovo veto iden~tified In thesoutharu part of Totask oblcnt (Western Sibaria) In May-laptoabar. 1962. (So* Table 1), Collctions were made in

Tablo 1. Species composition of mos-quitoes In southern Tomsk oblact(1962)

Numbar caught

2 . irn(. t I! LuI. . 60 28jl59 1e C. iiropt.,ni 61us 4 1b C4

4A.d. hCa~itir. irsl A%, -8

0.2A. - -r11220

to- Ae- Plle1r 4- 11 2 7It. At. scdahla )G. - - -

14. Ac. eri;ii D. . - I - 1 .115.At favscnsMW. 4 - 17

N.At bknislcv Dn. t2 - - 1218, MA.oI roichlad 1). . - 63 6

Totatl a &113350-

pi*forests along tLe Ob' River. Maximum numbers cf

mosqitoe wee reorde frm lae Ma toaid-ulosPe-

In lte Jn*: cde comunist0oquitoeu L-adc up 4E3.0% ofthe opuatin, -.i Ac-,#punctor 40.0. HrLzosvr

tabishd tatthai~o~tfavoradec temperaturof: for mote-quio ativty re etwenCO'C and 25*C.

MOSQUITO ECOLOGY IN THE TOMBK REGION

PoZbtakova, P. Ya., and A. 0. Hirayea. No di te ifte04Mprai~oi~ogtyai t parazitarnys botesni no. s, 1#694

In 1960, 762. female mosquitoes from the Asino Gistrietof the Tomsk region were captured and exualned, and i.species were found, dominated by audee puntdor, A#. oti-muni# and Ae. oeireraus. Phenology and percentage ratiosof individual species, and effects of temperature andlight on flight activity were studied in order to plan mos-quito control in Western Siberia,

ASSOCIATION: Laboratoriya parailtologii Biologicheskogoinotituta SO AN S5SR, Novosibirsk (Parasitology Laboratory,Biological Institute, SO All 5SSR) Z'4; , 34, (LP]

DIPTERA IN THE ANGARA RIVER DISTRICT

Raonitsin, S. P., S. 1. Makarova, and 0. A. Shovlesva.Distribution of Diptera , SimuZiidas in stream& of theAngara River Distriot. Nediteinekay4 prasitolopiya iparasitarnyye boZoeni, no. 2, 1956, 3.5.

In streams of the Angara River District water temperatureis the main influence on the distribution of blackflylarvae. Where the water temperature is 3-201C Pr oim -Zium aZpestre predominate; from 11-16, S.uZiuam vulgar*;at 210 and above, E eimiZium aureux, E. Latipea andHeliahia baffinenois. P. ahpestroe S. vulgare, andCnephia edwardoicana are most numerous. In streams,bloodsucking species seldom occur both in the larval andimago stages and have little practical importance.

ASSOCIATION: Otdeleniye biologii i ekologli nasekomykhEntomologicheskogo otdels Instituta meditlinskoy par&-sitologil i tropicheskoy meditainy im. Ye. I. Martsinov-

40-

4

skogo Ministerstvo zdravookhranenlya SSSR, Moskva (InsectBiology and Ecology Section, Entomology Department, Insti-tute of Medical Parasitology and Tropical Medicine, Minis-try of Health SSSR) C'0- V ,3 [L?]

BLOODSUCKING DIPTERA IN THE CHERNIZOV REGION OF THE UKRAINE

Shevchenko, A. K. Meditsinskaya parazitologiya i parazitar-nyye bolezni, no. 1, 1966, 28-32.

Forty..nine Dipteran species falling into three familieswere found in the middle part of the Resna River in theChernizov region. Species composition, breeding places,and scezonal prevalence were studied. Anopheles breedsnear the shores of the Seyma and Ubed Rivers. The greatestnumbers. were found in the Ubed delta. In spring Sch. mat.,.thtevseni are found principally near the Desna and Seyma.Culicidae were found in greatest numbers in the middle ofJune in quiet waters and in cisterns. Many Aedes speciesinhabit pee.t bogs and swarips. In spring Aedes bchningiand Ac. intruden:c were prevalent; in early summer, Ae.excrucian-in datper places Ac. macuzatue and Ae. fZave-occ.,t,; in July, Ar. dianteus and A.. cinorcus; and in August,Ac. ' The lond and clima.te conditions of this arertare favorable to th s type of insect.

ASSOCIATION: Naucho-isslcdovatcl'skiy institut biologilKh.r'kovskogo gosudarstvennogo universiteta im. Gorkoro(Biological Research Institute, Kharkov State University)

" - - ""C'A:A'';E3 i:" THE BLOO)D 3'iC!KI" 'i, I :IS'TC" -1:! T:-. A" TILT . S:'.V3iY

a az t oor.onents of the blood suckinr insect populationIn :-ha'-k:', reservoir area

- 41-

". 2.. ::::, i. :., . / . ". aa, t : , ,r,° .' a C Vcn '':

7 , ..., 77 AP70 07179

A forecz.st of anticipated changes in the population of bicod-.uc'int irsects (bitin , midges, horseflies, mosquitoes, and;natz) when the KacEchaayskiy reservoir is completed isCiscussed. This desert basin of the Ili iver is denselypo-'ulztel with a total of 7.9 species of bloodsuckinc in-sect. . The insect population is expected to decrease be-1ow the dam as overflow reservoirs dry up and periodici>Loodin cCeases. The population of Aedea mosquitoes inthtjs area will drop sharply. Above th. dan, the insectpopulation will drop ,hraly in the first year but recover'n 3-11 :ears, dep)endin; on the time of year and rate offilll- :n,; of the reservoir. CuZex,Anop, heZes , andCulioeta'osr,'.toes and com:!,.: species of horseflies and biting

:i~ilcs should find nu.erous good breeding places aroundt:'he e- reservoir, especiall:, in the shallow waters at theso.thern end. However, the new conditions will be unfavor-able 'or the nmalaria mosquitoes AnopheAcs r icuZipennis andAnc:;.!leo ;zyrcarus, especially in the western and northernareas of the reservoir. There is a potential hazard ofleishmaniasis if future settlements are created on therelttively pest-free northwest shore of the reservoir, sinceth; area adjoins a natural habitat of sandflie3 and gerbils.A.pFropriate measures must be taken in the first year ofexistence of the reservoir to keep the population of blood-such;irv insects under control. [is]

AUTHOR: Shumkov, M. A.

OAG: Department of Entomology and Zoology, Rostov-on-Don Scientific

Research Institute of Medical Parasitology, ministry of Public Health

RSFSR (Otdel entomologii i zoologii Rostovskogo-na-Donu nauchno-

issledovatel' skogo instituta meditsinskoy parazltologii Ministerstva

zdravookhranenliya RSFSR)

TITLE: Methods of detecting AEDES mosquito eggs in soil

-42

i

II

SOURCE: Meditsinskaya parazltoloriya I parazitarnyye bolezni, v. 35,no. 5, 1966, 615-617

4

TOPIC TAGS: insect, inscct control, A iP-mosquito, .501/

A]BSTRACT Soil oampi2s were taken f o the Northern Donets River andLurer Don (Letov eblast) flood plains in Septeuber-October,before the autumn rains, and were examined for ea a ofsix Ae*d. saecies (As. caspius, A*. v .ane#, A, otR*oCus,As. kehnngi., As. flaveoeone, and As. exoruoiana). Duringlaboratory examinatiou, air temperature was 2A.5-26.50C.and water temperature, 19-21.*5C. Multiple rehydrationand drying of soil spe6imens shoved that mess emuergencefrom diapausa in Aedse mosquitose was in February in thesteppe zone. In analysis of the soil specimens. hatched-ervase were counted, and species was determined for thosereaching ago III-IV. The :,umber of hatched larvae of agiven species served as an index of soil infestation withthat species. Ori& art. ias: 1 figure

PROTECTION OF DOMESTIC ANIMALS AGAINST BLOOD-SUCKING IN-SECTS

Teivunin, V. S., I. A. Zakemyrdin, V. V. Xormachov, andG. Xh. Xamay. Claea 46, No. 288223, Iaobrateniya,promyshZenn~yy obaxtsy, tovarnye znaki, no. 22, 966,282. AP7001443

Aqueous caulsions of Insceticides are usually applied tothe skin of doestic animals to protect them against blood-sucking insects (e.g., mosquitos). To increase the effec-tiveness and to derese the toxicity of the insecticides,in the proposed method, diethylmercapto-n-butylmethylpho .phine thioxide in used as the insecticide.

UDC: 632.952.2

ORG: Kazan Chemical Technology Institute Is. S. M. Utrov(Ka;enckly khintko-tekhnologichesksy lustitut) (PSI

- 43 -

EFFECT OF VOLGC ZAD RESERVOIR CONDITIONS ON BREEDING OFMOSQUITOES

ViV. T Theoaffct o hydrologieal conditions atthe Volgograd lccorvoir on brceding of bloodaucking mos-quitoco in the Volga floodpZain. teditnina aya parazito-Zogiia i para ita rfnye boZezni, v. 30, no. 2, 1967, 17-22.

AP7007781

The effect on the mosquito population of changing hydrologi-cal conditions in the Volga floodplain of Saratov oblast

due to creation of the Volgograd reservoir was studied in1961-1964. Seasonal fluctuations in the mosquito popula-tion nre dererrined to a large extent by the amount ofwater consumcd by the Volgograd and Kuybyshev hydroelectricpower stations. In the conpletely flooded lower part of

the reservoir, of course, mass breeding, of mosquitoes doesnot occur. In the Saratov-Engels area, most favorable con-

diLtions for the development of Acdes mosquitoes are createdin years of noderate floods in early spring, followed by

considcrable variations in the water level in spring and

surimer (as occurred in 1961 and 1962), Under these condi-tions, mass flights of mosquitoes occur in late May andagain in late June. In the Xarx-Volsk wooded floodplain,high floods covering large areas with shallow %yater promotemass breeding of mosquitoes (as in 1960). In the Halakovo-Khvalynsk floodplain, also, higher floods create larger

ireediiig areas (as in 1963). The species composition ofmosquitoes in the Engels area Is approximately: 63-75%Aedes vexans, 11% A. cantan3, 13% A. excrucianc, 14% A.caspius and A. dorsali and a few exarples of A. genioutatua,A. fZavesoenn, A. cunrl us, A. cataphyZZa, A. pulchritarois,

A. detrituc, and A. leucomeZas. Hans breeding of CuZezmodectus in favorable conditions occurs in July and August.The population of AnophcZee maciflipennie around Saratov-Engels has dropped considerably since the creation of the

reservoir. Control of Aedes mosquitoes in this area Is

best attempted when larvae are developing in late April

and early ay.

ORG: Saratov Regional Sanitary-Epideiiological Station

(Saratovskaya oblastnaya sonepidstantsiya)

.44"

( - -

K4

f77 i~NI4CTTCI1K TRIALS ON PREIMAGINAL AND IHAGINAL AEDE$ MOS-'. .' "QUITOESI. *

F Y~ : ,inooradvkatta, 0. jTcto of mn ceticido cm

F__ and imc,,nina etagov of Aedcs "ioequitoes. t4oditsinakayaSpara zi ' ,Uija i pa , a,,ta ,ny c bole.ni v. 36,, o . 1, 29 0 ,.

SE- 60. AP7007784

Lab o-tory tests of four orjanophosphoruc insecticides WurQ7 - eoducLd with praimainal .ede ljosquitoes in water fromnatural biotnpes (s wnps adjoining the Ob in Tyumcn oblast)tunder temperature conditions simulatinn the natural environ-ment. Adult mosquitoes were also tested with 1.indane. Ix-periments showted that wethylnitropho. (0,O-dimethy. 0-3-methyl-4-nitrophenyl thiophosphate) and trichlor.netaphos-3(O-ucthyl 0-ethyl 0-2,4,5-trichlorophenyl thinphosphate)were m ost toxic for Aedec larvae. The aininum dose ofmethyiritrophon causing 100% mortality of first- and second-stafe arvae was 0.001-0.002 & of commercial preparAtionor ta,, or 0.016 S/ 2 for larvae of stanes III anti IV, or

0.7 P/a2 for pupae. For trichlornetapho,;-3, the nininurmdoses v'cre 0.0032 gf/2 for first- and second-stage larvae,0.032 rgb 2 for third- and fourth-stage larvae, aind 4 g/rm2

for pupae. DiV' and methylacetophos (O-dinothyl S-carbethoxy-methyl thiophosphate) wer. less effective against larvne.The doses for larval stages should be considered approxi-mate, since the insecticidal activity of oreanophosphoruscompounds in water vtories with the teiperature aud pHl ofthe medium, the character of bottor sedi.ment, the vegetation,a.d other factors. For adult Acde , mosquitoe., the nosttoxic preparations were DDVP (0,0-diirethyl 0-2,2-diehlor-vinyl phosphate) with a minimuwi dosc causing 100% mortalityof 0.0007 Slm 2 , and 10% lindane dust, with a minimum dose

-of approximately 0.005 gl/ 2 . Smaller doses of insecticides

were effective for smaller mosquitoes. All the above doses

snust be verified under natural conditions.UDC: 615.777.25-07:614.449. 577.1

ORG: Central Scientific Research Disinfec ion Institute,

Hoscow (Tsentral'nyy nauchno-itsledovatel'skiy institut

dezinfektsii) (J5)

- 45 -

PLadimiroua, V. V. Ezperienoe of Pase breading of Aelesasgyptl L. Maditsinakaya parasitoZopiya i rararita"Mysbotsni, V. 36, no. 6, 12966 719-723. AP70O1494

A method of mass breeding of Aedes oaerpti mcnquitees usingvail cahinets with special tanks for raising larvae wasdescribed, This method, vhich can produce 2000-3000 mot-%uitoas In three to six days, has been in use since 1962,Good results are obtained with Infusions of guinea pig ex-crement and brewer's yeast in the larval tanks, Thu infu-sion ia partially replenished each week, and completelyevery tvo to three months. Temperature in the cabinets iskept at 26-28C, and humidity at 70-80Z. Adult mosquitoesintended for insecticide testing are kept in breading placesvith tanks coutaining cotton moictened vith glucora. Hos-quitoes destined for egg-laying are allowed in addition tofeed on guinea pigs or mice for three to four hr a day.This method of mass breeding of mosquitoes requires minimaltims and attention, since larvae are autouatically fed intotanks, and inagos fly out of the tanks into the breedingplaces. UDC: 595.771.082

ORG: Institute of Medical Parasitology and Tropical Medi-cine Va. Ye. 1. Martsinovskiy, Ministry of Public Health9SSR, Moscow (Institut meditsinskoy parauitolosii i tropi-chaskoy meditsiny Minioterstva sdravookhraneniyo SSSR)

-46-

- -1I .

-- 47

SETTLINtG OF COARSELY DISPERSED AER')SOLS IN THE ATMOSPHERIC3OUNIDARY LAYER

Diu ugkiy, V. F., I. F. Yaudohimov, V. .1. Kraai Znikov, K. P.Nikutin, Yu, S. KhaZ'Jkin, and ,. f. .um y. SottZing ofcoarel., diepoaed roeosols on tho k e;lyi q surfc ae ofthe grou:d. Lenilligtad. Gla'vnaya gcofiP'chcsk-1a obsor'a-toriya. Trudy, no. 286, 1966. Voprosy atmosaferno diffuaiii zagr'.a cnia vo adukha rProblen of atmopheriol diffusionand air polZution), 248-162. AT6035526

Results are presented for field experiments investigatingthe diffusion of coarsely dispersed aerosols ejected fromlinear sources into the surface boundary layer of the at-

amosphere and the settling of the dispersed phase on thesurface of the ground. The investigations (June-July1960 and 1961) involved flights of an AI1-2 airplane(170 kn/hr speed) fitted with spraying equipment, at heihtsof 100-600 m above a flat area measuring 10 x 20 km coveredwith rather horiogeneous but not dense vegetation averaging20-30 cm in height. The spray was a water-glycerin (60%technical grade) mixture. The airplane was flown along thewindward side uf the tast field at a gtiven height approxi-mately perpendicular to the wind direction. A total of200-400 check points were vpaced 500 n apart in transverserows, 500 or 1000 n apart. Two flat troughs (0,'125 m2 ) andone ?lass plnte (9 x 12 cn) were used to deterrmine by fluo-rescence analysis the amount of settled liquid; coated glassplates ,ere used to make a miv.roscopic amalysis of- theprecipitate. After the experirent, t'e liquid in the troughswas washed off with a specific anount of 0.1% laOH and0.1% OP-7 solutions in distilled water. The fluorescein

*concentration in the wash was measured with at EF-3 fluor-ometer and the dispersed phase settled in each trough wascalculated. The droplets settled on the glass plates wereexamined in transmitted light under a microscope equippedwith an eyepiece and reticle.

Curves were constructed of the total droplet densityversus the distance from the source. Subsequent analysisshowed that the ebserved systematically higher values ob-tained with the fluorescence analysis were due to failureto take account of the natural background effect, However,the agreenent was good enough to indicate that both methodswere valid.

ateorologlcal conditions existing during each expert-

ment woi-e checked by taking gradient monsurerents of the

moan wind speed, tcrperature, and Ihutidity at two points

on oppovite ends of the field at heip,hts of 0.4 and 1.6 n,

and ot helthtt of ron 25 to 600 m at one of these points.

Twolve experi.onts 'ere selected for qunntitative compari-

sons they had been conducted with uniforn sprnying during

ltea y aed favorable (in respect to wind direction) winds

and uniform tcnper.ture stratification in the surface bound-

F sty layer of the atmonphere.E

The most i portant fact detor,ined during the experi-

ments was that such aerosols may settle over areas as large

as hundreds of square kilometers in periods measured in

tens of minutes or hours, i.e., under conditions vhcn

meteorological conditions are functions not only of height,

as is usually assumed in the theory of atmospheric diffu-

lion, but of all-three spatial coordinates and time. (ERI

FILTRATION OF AEROSOLS BY LAYERS or FInROUS MATERIALS

XolZanov V, A., I. V. ItadiuhPvich, and V. G. Sasanova.Exporimcntal in:vantigation o.^ thte proceer of filtce'inpaerosola with Zay/cro of fibroU. materiaas, Zhurnal prik-

=___ iadoy kh ii, v. 39, no. 22, 166, 2726-2730. AP7003142

The first results obtained in an experimental investigation

of aerosol filtration usInG layers of fibers are presented

as a continuation of an earlier study of the precipitation

[ of aerosols on single isolated fibers of various diameters.

The experiments ,cre conducted with throe-dimensionnl layers

of Increasing porosity. The following materials were em-

ployed in the experiients: 1) staplc fibers of industrial

Srade nitron with an average diameter of 16 13, 2) FPP-15

fibrous material with an average fiber diarneter of 1.5 V,

and 3) fiberglnss, with an average diameter of 0.8-0.9 P.Procedures for preparing tho filters from each type of fiberare described. The expcrinents were conducted with poly-

dispersed polystyrene and vegetable oil aerosols having

- 49 -

knavn. pnrticle-diai.,etcr distribution. Acron;ol particlcaf rit ere countcd v'ith a continuous flow VDK-4 ultraraicru-scope to dete.rnici initial coneiutrationn, parsed throughtest filters at a constont flow npeed, and then redeter-minend after filtratioi,

The effectiveners of precipitaLion n is dcternrinedfrorm the filtration coefficient K %1th the follo,=ing as,.ump-tiont": the laycrs of filter tiaterinl have unifori poroity,identical diamctcr, and play thei saie 'role in the precipi-tation of aerosol particles (illustrated in text). Char-acteristic features of the precipitatln of aarosol parti-tIes in the three types of filter mntorial are discussed indetail.

The results of these experinents showed that in makintithe transition fron isolated single fibers to layers of thesane fibers, the filtration procers is corplicated by theeffects of various factors caucd by the structural ch.'r-aeteristics of the layers. The follow:ina conclusions %,eredrau: 1) Conparative experinents shoved that the natureof te depen(ence of effectiveness of precillitation onpnrtile sizes for fibers in a layer differed fron thatfor Isolated fibc. rr of the same diameter at identical flowspeeds. 2) '1ue change from isolatod fibcro to sin;;lefibers in a layer usmally decreases the selectivity of

aerosol particle sizes. 3) These peculiarities associated

-with precipitation on fiber layers can be explained by the

effect of their structure, the arrangeiaent of fibers, and

pact:ing irregularities.

BACTERIOLOGICAL WEAPONS

I1yasnanJho, A. Injurious factoro . BaotcrioZogicaZ wcaponf.Vojonnydy znaniya, no. 2, 100', 27-28. A117009494

Bactcriological wenpons are discussed as part of A newseries of popularized civil-defense articles, designed tosupplenent the 21-hr civil-defcnee course. Material forbacteriological weapons shoul.' meet the following req'uire-

-50-________________________________________________I

men ta: It should Igrew% on nrtif icial nvt ri ont mvcJia, remaiin* viaible and ififertiou for latIC pcri-ndr. under adversc condf -

tiuiu'i, rtui9L dryini, ,iiifec t raipidly anud in r, ;ll doses, mid

caue eere dVzeserl whihuna diffiult to kilov.cDrcrs owh ritry ar urrhcrand~ litt n ctuin ore nfcord, by hero~ohODicAIISM.a notfil norrnliy aprnthraxh tulrei, buc a scubi

glai~csuch ns OnInfoctcd typh cn, ao x bearoppedin,

thses rl oftinClous. [rJg otifl-rlro n smIca

becetdoe0eea husn qac io-ucsO

terrtor. Futhemore ma canbe nfeced y aeoso& o

-51-

APPENDIX

MEDLARS BIBLIOGRAPHY

ONMALARIA

1964 to date

Original page numbers of the

MEDLARS printout have been retained

__________I~

F PALC I VAC, V 'Sm . 5I I cL CY,

idLCI,IT P

APO'- jftUEh P;0 (C).ICA(CC) 119:58;7-6C4 jil. 67

7frcPmPVr # sIL ITARY 00tIC I' , OLASCF Iv F NLC TDO 'el r%,"f FV'C T;

dLCtIT CfPANAD ..FV.Ft CF C'LCRCLIE relSTAN'T FAAL'LI "Aip

TaAN5 fvkP CLIh CLJP'AT A5c 7;1624 1967ArLIT, eAQt CISEASES/ Ck r TiONA'PY, *CI-LCFC I!F/P-.Acf.A(.CCYNhMlC5, OL.APWC / ,FPRAPELTIC LSP, rExs.mL7, ASr-F/11-ir'PFL TIC OL, VFLO PV IIANC, wIC.t :9tALv ELF@.A/ , %r, Ti Fl-APY,I-Olki. f4),q *VALA;?J4/ ULr T.r Py , 4ALE (4) , ILITA Y "'-DCIMr,*PLA~wCC!!U' F4LCIrA;L;-/ Cr- r. IFFECTS, *pYkILFTI.AIL/ !!-FL ApE: TIC

~ *ft~.!v'/TwEPAELTT' OE, 7S9CPICAL wricik,:., -2'IT~fn TATFS

OCNK AT, PL6CWCHMAECN So CAIA. 1(FvALtPCP Cf MSALARIA, Exi-I TTTNe- rE'kLCV' 5EPS1TTvTlv T%' C~.jLOrC(,UIN'

SO. T -ECK T;.AILANC,TgAwS LCv 5CC T6RCP !'Er ioyc- AC W25-3c, lqe66AtCLicCFhCL, AUL.LTs AC.Er- hITLq CI-MLD rpEt-CooCL,

____*CI.LLPCCLjNF/ THERAPLIAIC i* Mir-PL RrS!STANCL, y ut, FrMALc(04-14) LJIOA (4), *POALARIAo iCATH~qAF'qVA ~'LE (4)v 'IrOLF V-E 9*PLAsvcrILP. eLCIPArLP-/ C.it eP FFECTS o PLA5/CCJILP k.IVAAI n.UC.EFFFCTS* TI.AILANfl (1)

CCNTACC4 Dc.' LLNJN J59 CCA7 PY GpCRL0mAE5iJTAKT FALCIPARLP ALl~IA FwCA CAP CDIA A1,r1 f'AL~yA,

*TQAP'5 AE 5CC TPC0 v~f )-~l- 57?417wZA, NCV 63CAI''cr!A (I)* OCI4LCkC.GLAfP Io *CH.LCQCLINF, OCQi C P,- 1STAt C rPICQCPIAL. wALARIA, vAl- YSTA (I)* *vLIAS"C(ILV F~kLClD0DL,

*pYoIMCThAP!Nr *GL I11ACP T, F, *ClIN 11

DFOGCAII. fPi, FCAELL RLCRi/. PEEI'iTANCE GF A STPA1- CP OLASOCCILPF*LCIPAQ110 F.fr'' 1ALA.A,AV'ER .j TACP M'IC 14:519-28, JLI ASAwcriArLI~L, OANTIMALA JI 14 CHLCLC M. INE, *C~LiC pESSTA'CEIVIgCOL9 01L. LOC TF4EWAY, O~rkCXYC,.-LORCCLJNE, *OALAPIA, MAL'YSTo(I)* *9LASWC'ILW FALCWAr., I, , Dyr.I WE T4AP IE, rL ,AoIM CLUNIN,..

CfvAki L 0-0 IVA~kIA To j;~

LA',(iT 2:A86-" 22 CC? 66ArLC MCI ArLLTs ELCr CrAKULATPe . *Pk A I., r' L AS 5/ F II"LC~YsPC I-L LO( L t1 J I TH.~APHiTIC ct., OGUC OF 51ST MOCE. ICkC -' L,mFlmTrC6Fftq I-Lt A 4), 5 jP(TIrN,-, IfTQAvENC(L5o *I 'mINrISCICnFS/ TOhL(;A;'LTIC L5. iglvFk FL',C1'2 TES75s Ol'ALAk1A/Mt'rL?(ATCk5. PjTL- ACr *PLASI~rl~L' F7&1 ftPARQ;W IV-ui~. t7 TSmpCCA-ote\ 11WF, , AET..5 TIJATLFIIr (1)

lv"ri Tty FALC1FAkPt~ 'ALANT- .,TI If~ F~C~T )~0.CAI

A%'.L API.LACkY CAQE (*I' I Ct4LrC'il-I',E / A iIjTt;MTjo': (. cSAGFO

*CI-LiCCLTNE/ THOtAPLOTC itE . V/M VlICA"LF Pf5Eh$1 C NTQCL*

CCCl.mPENCF 40, 'ALL (4) , 0 r. , Ar-'Cr*ILM FALCIPAPtY, 0pT'vA,;'I~l(/TI-CcpcELTIC LSE9 *CLIKNvi~ j i.EcAci'.YIC 'Ste T)-ATLA~qr, 11)

EPPFS P~s CFCrAmIN RI.. PCFi L"r

CLIl iCAL SILLDIES %1tI- A D . r~cI:5IST4NT 5TQAV Cc PLAS -,njp-FALrjnAl;Lw FWV' viETlt '

ArLI.1 9 *0I-LMCCLT\f./ TH~r;, eL T TC Ol CLINICAL QFSEA. Cr 44),CCFPAPATIVE STLJnY (4),9 *r- LGC RF$I5TA0'CE. IICRCPIAL* !-V~A': 14).V'ALr (4)9 *PLASPCCILP FAL--TPA-RL-/ ',*Ur- EFFFCrS* *PYpI"FTi.A~jE/T-Lg~$PFLTIC USE* VCi..TIM-, T-EQAPLUTIC LSL. VITP;'A (1)

ELF5 CF9 I-CC CC, kkAI.SEfvPLASb('LIL FALCIPAW~. RFSTcTAbT TC C -LCIQCCLJNE Of CAPIA,AP'EP j TRCP MrC 12:840-39 *rV 63

CAMAtn A( 1 ) *CiJLCFfl,Ihr , COLOC QrSITAfCE, tICPCOT"L,FLAb.'Cr;LI F.5LCIPARLwo rvclmETH4TNF, CLIN~INE

EVLFb CF, vd-AzTCN RI-, CI-EC, -- IST~rlES cts PALApIA AN!, Ahr, WLLES ?ALARACENSIS 10' CAtli3(- JA,

ELL'. wl-C 30:7-219 1564.ANCFW~ELE 9 CAP'UCCIA (1), Wv ALAqIAI *VCKKNE'V 'rTSASF5,FLASif'(TLt', rLAS'CI3LM Fi CICAPU109 PLASI'Cl! I UP MAL ANI AF oSTATISTICS

IAktdI.ASLTA To, VIi.AVAt Co %aTC H-ASk L~t-CFw'ET-CxVKF TN C14LCRr4,- I'ElRFSISTANT FALCIQAot.W Ml'LAQIA It,I- A ILAI'ILAh'C[T 1:1117-99 27 r.Ay 67*Cl-LCCCCLtNiE/ T~iEQAPEUTIC i E *CRLC. PEISTANCE9 mTCoQIALs

FE"ALF (4) "-LNAN (4),9 *, ALAkIA/ ,'UC. TI-EAPYs PALE (4),v*PLASMC!CILP FALCIOARL"'/ C~j FFECS *SLLFCNAPIIrE5/ THE APELTIC

LSE-, TI-ATLANr (1)

I-ARt11,TA To SUNTIAIRASAVA', Pt VIRAVAN CC-L(CCLINkEKFSI5TANT FALCiPArMUM MALARIA IN THATLAItr..LANCrET 2:657-609 2 CcT 65

*ACCLL5CFI'CE, CHILD, CltjIL', PRFsCFr.CL, *CPLORCCUINE/ THEPAPE-.TICL!L, *CRLG RFSISTANCF,, YToCnIALo U~N() INFANT, *~LoACPLC- Tt-ERApY, *pLASWPCCILP FALCTpI'RU-/ IRLC EFFFCTS% *0ui~~ACRTNE/TI-FPAPELTIC LCEs *CLININFi TI-ERAPELTIC LSE9 THI.~ALAr (1)

Q'EFFEPY ('-09 CCLL141c 1AF, S'(yNNFR JCANTT"'ALARIAL nRUC TRIALS C. A ?MLLTIRESICTAP-'T STCAIP. OF OLASMCCTU-1FALC 1PAPLMAMEQ J TRCF KFC 12:844-SC, 'NCV 63*AIPCiI.eLNE9 *ANTItVALAR1iLS9 *CHLCpCCLINF, CR'Y., pFSISTAkMCE.

?SICC.AAL,*PLASYCCILJP FAj*CIPAQU?'9 *PRItMACUIN~E9 *PYRTI1 FTHAF"TNE,*CLli INE9 TF&LILAND (1)

KpLATPACK~E Me KL0NGKt,PNLi.JPrA K, I.AQJNASLTA CJNFFLTIC!%-RATES CF VALARIAg PARASITES IN REIr PLC'Cr)CELLS voITi-1\CRVOL ANC DEFICIENIT GLC'.--HS AT-~yR~FAELAICLT 1:404-69 19 FE9 66*FRYTw-PCCYTES/ ENZYMCLCC.Y4 FFtPALF (41, *GLLCOFEPHCSPATF DEI-Y-CRCCENASE UEFICI'ICY/ CCCL -rENCFo I.MAN (4) *MALARTA:/ 0CCLPPEfiCEqP~ALE (4), *PLASPCCIL1 FAL.;TPARUM/ CATI-CCEFNICITY9 STAINS ANOSTAId.NC-, THAILANDC (1)

LE1CTLPS LJ9 v~itLLACE C'K9 PC FLI. PDAPPAK.EINT PFw.5CTCINESS Tr C -tCPCCLINF* PYklri'FTH.AMTNE9 ANn OLVIVJEIN 5TPAIf\S CF PI.ASF~CCTL)' F.LCTPARLM FPC!- VIFTNAV'.M'ILIT VEC 130:168-769 FEE ;.r)*C0-LCPCCLThE9 DRLC* RFSlSTPNCF, PQeIL VPUj T-Fp.Ai-y, *VALAPalIL1ARY M~EDICIN"E* *PLA5N,-PIlM FALCIPARUM, *PYIETH-i ,'IlFo*C1AeINEs VIETNAM (1)

iMCCAvF MEMALAKIA--A MILITAPY i'FCJCA, PcCRLFM YET wITI US*?MEC SEFV J CANADA 22:313-3., "Ay 66

* ANTIV'AL~pIALS1 THERAPELTIT LSEs IHLtMAN% CMe) IALARIA/ Dp(JG TI-FRAPY,Id6LAkTA/ lMCRTALITY9 *MA'LII: TAI CCCLUWRENCE9 *MILITARY "EDYCI!NEo*PLA,MCC1L FALCIPARLv, VYTNA (1)

VCKTGCPtRY R, EYLES OFCI-LCIFCCLINE RCSISTAN FALC'RA'LP !ALAPI.A IN rALAyA,TRAPS' FCY SCC TRCP F"E' IHYC~ S7:'09-16s NCV 0.*CI.LCCCLANID09 *CIILCRCCLtP'Et *rRLG pESISTANCE, #'ICpCPIALv*MPALAPIA, MALAYSIA (Me DoLASm'CrJltP FALCIPARUmY

FF-'C,.T rF ji Ci.5E FPC& THA Tg I W

14 V. . rTA, ~L C jL t FALC rAcL/q Ta.AILt.%[; (1)

FCArLL. ':, Pm %- C%Jo ALVI 7

FCC T LILW~l.

(;(I? ~cTr., LTt ThE, TI--' C (1)

ST C IN T 4T ApTI NA 0~-L- "Lr L T fvr 5 1 T kT flLS'o II.rI P~

IeLLI. .0-C 31:37;-,929 1964

PI-C~tJATE ACA'sT T - AEVAL EYTh,CyTTC FCP' I.c PF A T.AN Cr

* -.\TivfLA~lAL:3 C,-Lrc.~C7T. r. .G PEST5TA'C~s -'TC 'A;L*

*T \LTO-F Tsi. L~~ 1

'kvF -TI'.TIC% CF TI-E t'C95T TLYTY TC ;F.57i;5I' TIF nVLL-'o-%F C:0- TC SJ lAr C-LCP I* 61 (f'AqA; 11) y Crl~Jirrn A-4Ml f5TP'-T JCCF'Cl ICC1'A,%TT i-ALCCLT P) (LS

Arl'1;.L FXrhtlj'F"'TS (4)9 * iI'TWALART4L5/ rI-rrApFLTIC ll', 1) ;LkrFSTSTANCF9 ,.'TCPCPIAL, *-:,j-.A.~ AVIV:/ CRX. TPEP60Y9*PPVT-V'7 THERA.0 EL.TT L5E

4 _ _ _ _ _

A FlL~r STLty C"' TI-E FFFEC;c cr. A CCV@T*-ATICN CF CYCC-.UArIh~LP.6,aC,-r AP' A-CrlrLI.Y 6CANQ 'ALACQlA IN TI-F pPAIL A.r,, ;F tfw

A4Lf J TkCP i"cC 15:831-79 rl, 66ArCL-5CFNICE, AD)LLT 9 ACVEI *Ak*CrIAeLINE/ AI)fAIt;I5TvATll, & "CAE*ANTJIALAP14L'e, ArNIiNyTR",YCN r, ro5U-F., CHi'LL) CI4-t7 PdFSC-OCL4CELtIvrr-ACTII PpEFAf ATIC!r4 F.UVAN (4)9 V'FA~NT, U'4JriTTCNSIIUTfY'.SCLLAP, t-ICCir AGF --El% CU!NFA Me) PL.A5;'r!j., FALC1' AktdJpLMcjrl;TLP' VI\'AX

ACTTvE at AS!' IrlvLvI7.TjrN CF CIVIr AIZFF.5 11..F(CTr . iTT4 - STAFitTi.iAI\ A'NL SCLTl.AST ASIA cTRAJN5 (F PLAS"JC)It, rALCIPAOcM.rVILIr 0"F 131:5tuPPL:125c2-6., cEs* A6AF4TLAi IhSTL;-% (1)q AN'l'i f-XPEPI'PrrT9 (4), APFr-, A

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SA:.r.T.Ar~Lo PT,~cAS~J Ks Pli"LY JM

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*C-L(,RCCLjt.F, DkLG FPSTST-*Crq PyCI~C41AL, rPLu( TirPA yo *hPI A1T.ti,*PLb5vCrlL'- Ff-LCIPARLrA, *. RTMFTI-A-PINE, *CIf(~i± tLINI EsSTATISTICS, TCXICCLCCIC r- PT (4)

SWC51rr9.. AACI-LCI-CCL 1k-HFJSTA\1 FALC. nArLm "ALARJA IN~ PWLY8,StN(4PCPL tEL 1 4:3-59 vAr~ 63*CILLCcCLyr,'F9 *CPLC- PESI5F,AKCE* PICf7rP4L* *V~AL Ap.IM -ALAynIA (1)

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ACCrI - 5CFrCt, AOLLT A !EV , A , H~cIMCLYTTC/ C'fPTCJALLY 1:It,#'ICFU-* CALC,'IJA kACI-s *CI-E'.'IsTc, ,, PHYSTCAL/ TIE4APFLTIC L-Si, r4PSCI.E/

ArvF4 .F. EFVrCTSq *.ASCNF/ Th-EPAPELTTC '.SE, HL4'.Af- (4) * MAL.'-RIAIC' Lr* T F PA Y, 9 ALE (4),o TL'TTARY wFflJCIt'l, *DLA Sllr%T I

* FALrI?'0L2J/ CLC FFFECT59 rSYCI4CSES, T.X ICq *V.U~TI)r~ TiFFAFfUTICLScr. 9 ('ITTEC 'T/ATES Ms) TETNjAV (1)

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57(.tIjF~ Ck Thc' rISTRIOLTIC iAKL TPAN"vI91CTV OlF PALAp Is. A -,,,FTLUmtc-1 AtrNC ACkIGT~I- V~ PALAY'A.AF~, rICD VLC r/AASIT ',7:23,-54, JLN 61AFr:rk, ALL-ILKS ((.LFX - cr I rEO.!rLCCy t 4F TLAF T A~S I t t AiT1SLt rVLY.~ *PALAPIt, '-AL AY iA Ml) s 'CS;LI'TCFS* --I. AS*A.M yi.M

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AC.jr$T tN, L~d~l Lt IW'ICKT C(FivF CASFS Cl: MALARIA CALt.FC- 8y CLASM"IL(U FALCIP~tr,l (PCI)

TPCr-ICAL CLTAY. TF

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C1tFtTAIN' CC* GbJOLSEK r'C9 rjrSrN CHA~PTL6LCEINS ANC TRAI'FFESIt',S IN VELANE51A: PFLATICN T' HPOW-BIN,

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CAVT6, hiL5C1'F FEATLRES CF PALAF.IA T- LILT, PCRTLcGLFSF TIOCP, lflt.T"16 l9E-64,ANN TCF VED !A4 ASIT 59:14--529 JLN 6'5*AMC!LT~rLTNEq AN!YTA *C,.LCFC(GL;ANMt~, *C1-LCRCCUtr9 fTACNC TS9

LAPC .PTCkYi 'RUC- TILtOAPYo ErltEEWICLOCyo *lJAL/FTAl*PYcIET-A~'lN:! SEACCNS, ?IIVCP (1)

OrTStNvet AA(APRCPCE CF C!iAN(-S I' T).F ko8TER ;FACTC:; A!N(.SATTaY-FIC ITCLCCICAL r-P'CITJTCNS IN TlE Lo-~Etz MCN P~'I! tFTEczTI-E (CNSTRLCTICfi CF DWE T .-MLTAN DESFQVCIR) CR1.5)P~1EG -APAZIT ("-CSKAIA) 33:06~-5, JLL-ALC 64Er1FkPICLCCY* *I'ALAFIA, ovCSCLITC 59 USSP (1) *WATFR SUPPLY

CLlA,\TNA IN, ZLKCVA TATPAl"5'P'SSTCN CF PALA;TA By OLCCr TR~f45FL5ICk,: AN FPTDrr TlCIClkCL-STt-rY IN Tl-E LSSRr.I / LLI WFC 33:853-6, 1955*PMV!CC TF.ANSFLSTCl/ ACVERS- EFFFCTS9 IPd.Af. 4, *O'ALaoIA/

CCCI.KPENCE9 USSR (1)

CZI-AFAPCSCAA(C'. CASFS CF C1.ARTAN mALAPA TNT-E KLEIST ~Gc &MEiTA

IN 1563) (PUS)M~FC 1 ARAZTT (tCSKVA) 33:31-Y-89 wAY-JLKI 64

* AZEPLAIJAN Me) EFTCFF'TCLt-Y. *MALAR!A

EYLFS- LE, ihARPEf- mo (-LINNIfrEPTTFTCATTIt CF ANCPIFL9% L820ACE.N'S' INTiRCLATUS Ar A ~,TT~CFM'CrKLY MALARIA Ti IvALAYA*

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MA A T k M G C M E *f TjAILA' t. (1)

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ACCU.SCENCE, EPICEVICLCEY: *C..UCCSEPHCSpj-ATF r.E14y- rD4-lGFNvAFCFFICIEKCY, TNFANT . NElker- h *IOL4JAe tTr%!L' ArjF THAILAP'" (1)

FLATZ C, PIK C9 SPINC.AP 5EMLCLCETft E ANTU EETTI-Ai ASEAEP-TAI Ti-PIR !rISTQRu!ATIC' TN Ti-AyLAN'.

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FRAS1P C*'.q C.RI NikOLC Ps. STA- *AT"YANI CPCLLCS C-CLLCC-6-PCF'wATE L HYCPfE ASE (r-6PC) CEFIC1':P.Cy, A INCP"ALIAECCLCeHtS, ANL; TIALASSA-*"IA TN yU':fSLAIh.*~j VFIG CENFT 3:35-41, F"AR A,.CCLCi iiLINOKt~ES/ CCCLDRZENC , FFPMALE Ws) *GLLCCqmPH0Sp !tATE C7HY-CPCW SE 6FTCENCY CCL QE'C~ * XCC-COIN, AN'CPI.CCC(.IkQE(EFTIEN.Y W9C 1-.AJI CC lR.EC.jS VAIFC(4)L

*TI-ALA-ScEMIA/ CCCURR1N'CF* YLCGCSLAVY" (1I)

to

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/ LLC-'AO1A (1), CC;vV,PATCAE1, - !TSr-A E CCiNTPCLo *!-ALAPII' ti',TPCL.

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EPIr!L"ICLC(.Y% *IIALAIR1A It f-- 1f *O;TF SUPPLY

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C -1 I[ (Pf't;) H4:491_7, Alit, bw

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(TVmFCIC\S FPCPV Tlw 5'A1 1 CY FpTDF!:TC 1561 IN TwF Pr.:PLF.5

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Z AF'tL7 FCRT 'ILL (%Iv*.A) 5-.:471-4% 15 ,APR 65

*MAI.AP16/ UIjvr.C5tS PCLA' r (1)9 *9-ALLPCX/ CCCUrEh1''.Fs

*SWALLFCx/ PkcvENTICf' & CC-TIkfLo *c!-LLPC~k VACCIP!Fo \VACCINATTON

I-t.'CK C(mcrICAL FxPL*EIFENCES TN A "FlTI-. SLM'%T"' ).KSPITAL) eGup)

Z TPCPENWEL P.AFASTT 1b:227-'AC, JL'- A5

CF5E1AN SECTTCNI', CYSENTFr Vo AMEPIC/ rCCLrPENCF , FLMLti (4)s

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PARA5TITTC C157ASES IN TI-E .FFL-ELIC CF~ GI.INEA (EASFf. UP' f AT-%

CoiriL~fr rLRI".C TWE YFARS l9c9-1q6I)* Ile r'ALAPIA, IT IN!CE-CE

AR'CNc- VTSrTTCR FRCV IWE LC!- AN^' CTw'::P CCUNTIOTES) IQLS)

AF, TCA, KF5TE*N Ms) EPIr. '-IrLCE"'9 *VLFA U55P (1)

KICt-i%' Co CL,,TAIN CC* GCRc,' G cC0 -'-cc A~A:*v It~ MFL- SA: A' i-FYTCL~~rCAL IAVY f-CrC~CI- I L _r N CFI P APL.A-N Ei. - I' '.f

vFfl J tt.ST 2:^80-19 5 iNCV A*ArFi- T~ I-1tMCLyT1C/ CCCLR~ C, o ~ T~ KfPrOCIiCt~IC/ m(rkC.p.(CE,

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TLr% S CP

2LLI. 'AFC '43:drb-dl 1965*gL2ri.:r TbAr\SFI.SICN/ Ar!VFRe, Fr-FFFCTS, LJ-r/At\ (4),9 *"AL ir-jSk/

CCI..p..QtI~CfBv YLCCSLAVTA (11

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(STtjTFS CI\ T'-E EPIICEllICL(r v rF IvAL"I.IA IN NCPTIle~r ' 4.CTvTSTCt\ CF lvkDT- VIETIAW rtTr IAIAWIOLCGIC ZrNVSI (RLS)

IVCL PAPAZIT (*CSKVA) 34:lQ,.-94, M~ARAPR 65I-LI/A: (4.) *'%ALAPIA/ CCCL'-cEiCF9 VIFTI\AV' (1)

lC(CvcPNI vij, VjAJIt5 i

LTVFii r!5EASE IN TI-E TEPFI*Crpv i!F pl~rt.A-kEt GtIN'EA: A PCPCPSy

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*LIVLtR nIcEAScc/ CCCL"qRFN( , *LIVEW 'TSEASFSI PATI-CLOCY, LIVrRNFCFLtAS"/ PATI-CLCGY, MAL.flA/ PATIOC.C'lYt FALF (4.19 "Inr.LF AGE9

12

fWALr.CC~lt YeT VINES AF114 IF-FLUFrS~r CF Cl-RC,1C T: -LTtr; s FLCCL-Pr .5(j-'F TO ;F -Ej C.LTNEA

LA;,CltT 2:2o2-4., 30 4LL 66Ar7LL T FLr-/Af% (4), PYPE c -c SIrN / ftIr!LCGY, .YOF.rTF 51 Y/'CCC' KFP.CF.-, 'ALAwlA/ CCCI. OELCF, *mALlPr/%/ PHYSTC0ATt CLOS'Y,M10TULE AC-F, *EIA r-Llt.FA C179 RFSPIwlTC4Y FL?CTICt TESTr,,RF5P-lPA7CQY TV-ACT INEFCTIC. c/ CCCLRRFNCk, *PFSP'W/.TCPf# TPACTIlNFFtTICN5/ P-YSjCPMIl-CLC., , SPLr~E.'/ PP-Y51CP6TkCLC-Y

(APlOLPCE CF Tv-i' PTHCr-EKEcc "F pRCtAPE'\CES CF Tyntfl'CI A~J) Tv-rR

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13

RAI.ANLAN (.P ~ALAcI.C4. F- HEYNENA~c CPt.LAL TIC'NIN: A (CIefNEr~ W- 4ITCLCC-ICAl., SIAVEy, T, PPE-SWIIT ST'TLSCF HLY11AN PALA t-IA r.N TH-E Is Ah r*

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IZArNfCe.CAI AA, OIAPTC. Ad-, i.YLF5 LEiNLAmTA IN" Fa;LlS.

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ST/ATI (1) VIFTW~AIM (1)

SPF!"(%P IFI-A~wC(LCbT, LvELS It. T rOIt1PECASTEALX ISLANrS IN RELATICN. TO

VLA -TA ANU. N'.TP!TICN. 2.yr j /'LST 1:A55-79 29 AFF 67Ar.CLLSCFIVCEV ArLLT9 AC-I,o *ANFMTA/ CCCI.PPENCE9 Cp~qLLu Cl-TLDoPRE LI-CCL, DIETAPY F!;CTEI. , Fh 'ALE ('4)9 * 14 E MC G L:'I,. pI-F!"CLCPIh:CIET9Y, I- L 1A N (, TNFANTq INFAr..Tq N,.PCP% 9 *MALAPIAIcCC'.1-P~ErCF. "ALE (4)o NF (-L INEP ( 1) Nt :ThI T Icm! s-y

TYt,(SKI.A NA(CPCLPIKC CF r: V!VAX STRA-PS BASED~ CN TYPES OF I.NCjuL!ATTCN) (RLS)PEC I-ARAZTT (MCSKVA) 33:2r;-119 MAR-APR 64*6;TtPCpr~ VECTCR59 CLASS5,sIrATICN9 CLINICAL PESFARC.. (14).pEXPFI-TMF3\TAL LAP' 57LLY (4)'. *ALARTA9 *NC5CUITCFSs OPLASMCCIUMVIVAA9 LSSP (1)

14

T1L(L %SK~jA NA, VkUELLVSKAdj, Lc ,,QTpvAAyF -eT-CCLIvICAL AhC 1'XP EiTL -TLrIFS C, (MTr ALt FLTC

ELCC[ TQANFLSIrt AN[ tPF7 r S FCIk PwfVF!\TIVC- ITS f1Cr1,Prc;rF,e'.LL 'li.C 33:P43-519 1*165*ANTLIVLAF1ALc/ 1-RAVELT, LC-E, *'HLCCT-. TF''N'-FL5!C/0V 'F~S

EFFF(1Tb * P' '." (4), t PALO'(A riCOPiFNCF9 *PALAPIA/ ;O'PT^ &

TCNA 'LNA S(CA,5tA CF TPCn-ICALC1CErLASIt %N ;CKI-11!ETS CF T14F TI STITTtcF

*A-*FtIAcIct -NCNC(LF 9 rFT -'NTCLCCYt 0*LIfTtIc~ILSt 'F,

*A'v '-VL P'EIrIC IVE, FCL-%NC (09 , S"ALLorx~, *TRAC14~,, *TP'.P IC ,L

PF4 I( I Eo 4 Y"L'-Ok FIVEP

T1 .,( Co C-k(.- KI9 I-CL 5F

A STL7> CN T.r mCPFI-CLCCy ETI,%L.',*y rF LAf"OE1C, I vr TS.

ALCCI-CLIS'V, (rJINA (1lie CgrNkCITAI159 FPICFVTCLCCY9 jF,.. 1111tI,

C!5ri.FrS, V'AIICLCCG, ST-TIFTTCS

0 ~, t.YLf S Cc 9 v-I.APfT. ;I-7- bk. C r-VT I PIL IT y C F 11A 1. Ay 'Nr pI- EL I ' I TC w L A'SO r ;u1- C YP?-ZMCI t

t2ASTII-IFLI. IIVIT;.1' J PALA" 17:85-I05o Ak 61

If'JvFTICAIICiN5 LEACIFh' TC 16f IrENTIFICITICN CF t:EV"'~r, %,F F

AOCPFFLFS LVt14CSL5 CkCLP Af IE PrC'YPfLr VFCTrkC CF 1FLP C

*A1,C I-LLESt *APTICCACTYLP. FXPLri-lENITAL LAr~ STLY (Mt *1r5'fCT

VCTAS, *PALAPIA9 -A L AV "yA 1) *1'ICr-

STI.rlFS Ir C.ITF3PI~hE TI-F \ CICfqS rF C.<Ly UALAcIA Ti .1-LAIA.ANr\ PcCc PLC PAPASIT )8:5(--.779 PA OAFL'rSo *ANCP,-ELES* CLLEV* : LCGcAI~I.Y, IrSFCT VcCTCpcq *MLk

VALAYCI.6 (lit *VrNKL-Y r.A~ ir5, ,0r:SCLITCLS9 *rLA~t.C.yU' MAL!RIA9

ZVCQ,LEV rT(Cr' TI- WerPc7 rF ?PC5rLTI":i T N srC .('IcNs rF THE (LPPLAPFr'r1 c LA) f RLSC

' vcEtqrrFr Zt- 1:47-99 1964

EF111."ICLrCO *rFALAIA9 .CLSCI.IITCE~s LSSF (1)

VWI-C C .;CNI\ p :I gq-215, 9.JLN ,4A F;r I(n *I1A, SC I. T-EP rTtd ( Fl!IrL"rLrGY, Fk.D(PF. I I

TP TLrtAT TLN A I A(,-NCJ5 cc 1hI4..APIt. (.1NTIECL9 " ErITrIRA FAr.' TsLANI)S

APLI L CA[IFtP

?PEL rh;AIT (."CSKVA) 34:lct-5, m~-APR 65AFLI-..I ISTPI% (1), I-L6 AN (4. *01,ALA'Il PREVFN!TTCM £C(-P'TPrL

ANT IPC- SS(PCTtN\1TAL FC(I CF P'ALAP~f' TN Tt-E NtrCL:tV 4ECICK (,: Ti-F III,'AI'EA'\[. i'1"FLTA4TL P-LANJS FrR tv. - AP!A C'N ;CL) (RLS)P'FI. PFAF>ZTT ("CSKVA) 33:72: -4% 'lC/-f'LC 644?LA-pIA rCNT'"CL, LKIA!NF (1)

ASSI 4I Er,(I-UwO&? MALARIA: A ZCU',CSV.) (GrP)CELT5rl- !'FL v-CHR Sl:lC03-, '7 MAY h6A

~ IL

WCP!:LNTS Ff/ TH-E I-ISTCPY --c 'ALAr~ll CrCTQCl. IN GGIi(PUS)NEC p A4AZTT 1CVA 3:44,-8% JLIA 64C.FCi~t.yAN Sbw I) I-ITCVY : HSITr.Ry rl: I/'LTCI;,r Iw (7EpNT0.,I-T5TLPY CF~ rL,':[CINE9 2CTI - rT~ *IALAPIA CCI,'T;CL

BFi\P'LTT (F, v.'RREI No C-Er.EICLCY CF THW SJPI P~ALA TAS CF SCLTi-EAST AI[ae I* S Cnw~rO~v OFTI-F cav2cr1AP4 STRAIN CF PL .51.CUTU' yCvLj PAIINASIT 52:f32-fl, 6'.G 641AKIP'i L FAPERI"ENTS (4.), N Cfl.FLr59 k5JAs SCUTI'EASTFJ' (1)9CA~vt~ 1f "1), YCIKEY C151 %cV4rSrLITCES, *PLA5MO.4yUM/ C'FrWTH

£rrVFLCPvE~&NT, SALIvARY (-* Al\,,5/ "ICgrPI ICLC-y

BE!I?\LTT (F, 6RPEP" P, (I-Er r~21IrJCC-y CF Thr 5SWIA1. PALA' T/AP rF SrUTHEFAST Acfl IT* THEiSLSCLPTII!TLITY OF SCPE PAL.VYS!Ah! mOS,-UITCES TO TNF&CM wITl- FIVESTF.AINS CF PL"SPCCILM CYNC',PV-1.

PAk.A5IT 52:625-319 AL6A,~AN vm4L EXPERIVEPIT9 (', 9 l,'C'iFL':S AnIAq SrUTI-FASTE;tj (1),INFECTICho ML~LAY5 IA (1), "CP,'FY DISEA5ES, *PLASl!CD 1 Lr4/ (RC TH f,C F vELrFM ~E" T

16

!FNNETT C-F, AAbPRN I'q CI-ECiEJCILCe*Y CF TI- SIM1AP P~ALA je! rF SrLTi-IAST ASIA, TV, !,)PCP%-GC0 CFFCLC cTRATr5 17F PLASI~('CIO' CY:'CvCUJI.J VPmAIA5[ 52:639-469 AL(F f-AlN1MAL PkRJVENTS (4)1, *,VrHLS fA 1 SeLTlFASTFL"' (1)9I'Ct.'ty PtSEASrs, UPLSCLJT-rS9 *PLAscvCr!IU/ GRrWT. & -FIE'L0PV!"JT*SAI-Tv6A.Y CLAN^S/ l-ICF 3!FCLr(-rY

EICLCr-y Cr THr mALAYSIAN iCAN CO PLAS/COIL'o JL;XTA*\-C..'rAOFVFP IAI\T AfC f'CPOES, lQ1'J. - LIFE CYCLE CF TH-E FPYTI-iCCYTICF~AbaTTF IN TI-E AVIAt, ICST:4 VA&kASIT 52:1,53-q, AIC 1ANIMA0L EXPEPI"ENTS (4.19 ALP'IdA, '4VTA;i./ PLCt.Di '.ALAySIA (1),FERICf'ICITy9 *PLASt'CFILP/ 96CwTH 6 I~v!LCPIVFNT, SrECIrbSPECIFICITY

TPANSVInSILN CF A tNEg STAAv.,, rF pLA5Y(rCIIY Cv (,WCU-T T:AA'

J PAikA5TT 51:79-80, FOB 65

*M'CS41.jTCr59 *PLA-cMCCiLyt, Z'tNC.E

STLrlo'S CN' CCACT ATIMALAPTALc* Is TIE EFFECT (;F A SI"-L INJECTIO-1CF T1 F 'EPLT %NTIVALAPIAL T-gCl ("C4YCLAR") Ci'v RPLAPST-,' vTvAyP~AL~P.TA AC(GLI E[ IN .F~W CLr'E.ME[; J /1LST 2:r,88-929 24 SP, tAArL~L, AP'NCTRANSFEF.ASFS/ QLCr.l *ANTITALARTALS/ TNE..APFuTIC UJSF,AtLSTI.AL IA (I), v LCCL CELI. CCLNTq Ci-rLINESTETRASF/ Ltii-Ewh6CQ17 6ECL6NCF'Y HLMAN (4), JM1JVCT Itv ' S.INTPAPILSCLLAR, MALARIA/ ric.G TIEPAIWY, *WALARIA/ PfOEV.:TTCN 6CCI\Tr(CL* VAL: (4)9 NEV% f-i tt~rA (1)

t3LA( p PI-- IFNESSY wbo MPCtilLA bSTLrlFs CN: CEPCT ANTIIYALARIAL% 2o Tio-E EFFECT OF A 50IMPLE INjErTIOjCF 'jniF CEcCT ANTIMALAoIAL '7-564 CN ,RELAPSJ'C? VIVax MALArTAACCL IQU' IN N W GLINEAsPFEC j ALST 2:qO8-119 22 Cc. 6AAIX.LT, *AI\TI'.'ALAPIALS/ TI--l-ArEUTTC L'SEo I-UIA% (4), "ALF (4)KEA (,UINEA (1)

ER.LC-0WATT LJ(C1-CT-EPAPy IN MALARIA f. ACrCATTCN) (. s)P"E1C PARAZ17 (tr.CSKVA) 343641-9, NiCV-OFC 65*ANTImtLAPIAL5/ THERAPELTIr LFE9 IILIAN (4)9 *f.4ALAPJA/ PPC'VENTICN

6CCmTgCLo L!SP (1)

1?

(CA NJ ACQ.Z TNC T v C ILC4 AW9 A,'1,ITESCL r(F:,,r; T9-E ANTYAL'RIAL ACT~t\t I."ITI1TEC HY PP()FESSCP ICr!CANT/I'L?INC Tr Ti-17 Pi;CSFIT cT: GF CF WAL?.ITP RAF~IC.TIC, AT ThEFNAT 1LNA~L LAi\C YTE7hATTCNAL I.EvELSI PRPITCCUOTCLCCIA eHLCLR) e:51J9-229 Nrv-cFC 6c3E!CCp~ApFS~F (4), 1-I5TCRY. *PfALAPIA rrNT;CL9 , IVI 1

C'-TN %o CCNTACCS Pc., CCAV V -

A (aTUWILLY ACcbUITEC ':LCT1Tt -T~ YPE 'AL0RI IN' "AIN T A,;F4.L TO

SCIF-CE 149:b659 2C olk 65~

[ CTLCA I', LLPASCrC Go tFLLT:1 F(R~L~FCK 71"E FXPERIP~EIL TPAINSOISSIC\% rF PLAISOCrT, 64ALAPA

T C 1-)6 FP)ARC- PCLP -AT - X: flICF;C8i ;13:763-76* SEF- 64

S(40' , *'ALARIA9 *FL-5mrDCTL VALARIAE9 RLMNAvIA (1)

CCLL1NS k.Ft SvIN\ER jC, Cto EC.FLLC.%ESCENT AA'IECCY DEACTt#rNc 6GAINST SIX 5PcCJES CF epI'TANI'6LAFkT. IN MC-'KEvS FikCM P- TA ANID IWAAYSIh.

*AFNTPrIF5* ANTICEN-AKTT iCLY PEACfICNF, *Ah'TTGr,* FX0EQIM':N7ALLA7 5%r!Y (4). *FLLCRESCF.T ibNTIPOry TLC-ITC, INrIA tI,,*?/ALAPRI8, MALAYSIA (1), rCNKEV PISEASIES, *PLOSCnIU,'

CCRPFl CETTI A(CAI bFS CF PELAPSEE CF ?MAL-I.5L INFECTIC, '~ VAN AM l K-NM~'FS) f(5)F~EE vARAZTT ("CSKVA) 14:671-7% NICV-'EC f65I-LV Vr (4), *'IALAPIA9 *VAr ARTA/ VEIEPV-.ARYq *wC&IKcy J'SFASES

CLRTPT CC, UALI)CARTEIN A, -rW;VN JCCLr I4A'AGELI TININS: 001~ AL IN\CTDENCF IN M~ELAN'ESIAN I.OPl.iLAT1CNS*

*ANTjPCr!FS, *CCLIC9 ccpc;FpFNT FIxAtTIrN TFSTS, C.AMl GLC.PLLIN97%9 fE'vACGLUTNATIVt%, IF".w.NCELErTIwCDICRES1Sq lACQCL0PtLINS.MALAwTIA, NEw CUINEA tj)q cCLTH cACIFIC ISLfV (109 STATISTICS

CALLLCFF C* (LYv~-CM'ATCSES If\ AF~qyCAN ~ij '~)(GEP)

ARCI- K;NrFk ErLK 170:51-69 F~ 64f AFRTCA9 CFNTRAL (1)9 bLRY'TTT'S LYMP-C' (3)9 CFTLrq, C,.0r-RAP:.Y%

0,IEC(CLCbTNSq M~CRMAL9 I~,,Tr~, LYPPI-Cr'A, *LYF0HICSAprCMsA,*wALAP~IA, *MIAXILLAP~y NFC~ AS'3, N~FCQRCES, PECOLAiv rrYCLCC~Y, \F.CL1N~A (1), *CNCCCEr\!C VI*-LS%

I d------------------------

CELLkc J~J JP9 RLSSELL PKAtK Ar.ALY8TS Cc FEVERS CF (.. le~o-WrN; r4kTC-!r. IN, A4wFRYCAk. SCLDIF.-' ! 1

A1XCLJ *APPCVIPLS IIf~lECJ1;- 'c/ I'IAGNCr,5 C?-IKUNCGUNYA VIpL5/I CLATJCN 1, PI.RIFrCATICK, *LFN47UF/ GrACNC51pis tF.NCOUF WqPUS/ISCLATICN & PLRIF!CATICNO lj~iGk~CcJ5, CIFFEIEftTT1AL, F-TrPITIS/ET~rLrcy, *FFVFR/ E7TCLCr> * FLLrk&SCE"'T A.NTIe'CCY TEOi-NIC,

P~ALF (4.),9* IT L ITARY 9ErI IC ?F, *cCLLR TYpt-KS/ t 'AQ(NO5TSq L'f 1TEr.

CCALSATIvF AGcNTS CF SIVIA ?MALAkTAs To CALSAT1vE AeZEMTS rF TI-r PeVtVAA~ A tL p. "ALAPIAE TYPFI (RL1S)IFC LJ-pFjZTI (CSKVA) 34:60'-69 NCV-CEC 65* WALoAPIAI VETrRTNAkyg *.V vI vrIxEAcSs/ VICIATCLCC-y,*PLf.5v'rr!L?'/ CLASSIFICATIr,

CFSCv.1TZ CS9 SAAvF JlA STLr~Y Cp., Tb~r MATLPAL 1-Jc;rpy VF I'VOTTy TC ?WfLAPtA INI PiqoTELTEr00" tNPCTWCTC PCPLLAJTC~t Cr AuSTOJAL1N NEFW GLIMEA.r'FC ~J IALAYA tg:36-79 SEP 4'JP.'*LiTTYv *,MALtARTA, NEh ef~ifEA (1)

CFSr6TT7 PS9 SAAVETI-F kPPLICATIrN CF TI-F IiAF GCLTTNATICN TEST Tr A STUJY (IF TI-rImell-f-JTy TL NO-LARTA IN' PC.TFvCTEr ANI uNOPCTE-CTEr POPULL.TION" C.FCUPSJN ALSTRALIAN NEh C-L!-lEAeSLLL 4I-C 32:149-59, 1965*'EVAC.CLLINtATICNP *IVALAPi&, NI~ GLNE (1)

CCPrEV1C C, STEFANCVSCI S(Ctjr FxPEFIFNCE WITP- TI-F Ut rF CAppP~v IN PFMCPRCPHYLAXTS CF

PALA'4.TA IN 196C ANC lq6l T T-E CFVI'ELJJE RFGTCN--) (SEP)/ vC.jrZA6,T PNFCL 2C:197-2C119 ApR 63

*N'ALARIA CCfvTCCL, *PY~ItPFrl4AP/JNE9 yUICCrSLAVIA (1)

CLK)I-'FNANA NN(FACTrFs rETEcMINIKC TI-E PrCSTtdTLTTY CF RENEWED MALARIATPAP-SPSISICr\ TN APEAS AI-E~r !?LApTA HAS HEEN FRtADyCATF'i (RUS)1PFC t-AFAZIT (WCSKVA 14:631-69 NCV-rEC 65IILPVAI (W% *kALAP3IAI PREVrNTTCN & CCNTRCL, *MCSOL;rTO COPITRCL,LSSP (1)

ftci,~' J Y A ~ ~ A t ~ _ : T CFA. 'vllG FTT ~I: 5 r' iFATC5 rI

eCYL%~ fr, CL~' FL, bAW'FFN I

Tl ALAkC~ L

M-I*" TF, Fi t*' rL, CL 1-, ht #lT FL CA I~ Q A(RANCTL. Y1MEI . CF.,O V f S(4) LAR PAI!ft -CL, Or~ 'LMIt ~ c~

I.YLCLAUF, L-VF L kklF

EyCr,.FtT, AL AbiA PS'AvL,, (4). C'CNKFYc PI CLPPIF JLA s, *ILAs, t

PLQVFY,~p~f CF C he~ cTF .95) , PATAp(RL5)rFTE AAA- - O

A6 C F h LFE9 *ALPI AN'YI T I~fj *V'TCN F CrIt~tC * &: LATA)jL

FrcrCVA SF(7 Tt OCLE CF EANTLDNAC~rTT,. Af I wrATCAALS n "'ALP F,AJMST rF(L'VFA CF 6Hp - 1ATEP* ACS) ( cI;T F I 1 CLS)hT*I"E A hz Fr (ATr.C5*v I-LPZAN- 14-.JU )s *A PO/F;9Vf3 Af fc RL 5

iJTreff t F6ICALT LI CrE.A~r y OwFALART r. OrCTT L ' eSLF;

(pus

YFC -t ZTT ('-'SKV ) 3 W~we SE -CC '4

(FINLrI KKIi, FOK1NA EN(C(.TSTANLrNC~ COP. PI-YSTCI-1 CAPLrS jUA.% FINLAY (1;433-1915)) (RLS)SCVFT ZrmPAVCCI-P 24.:5q-639 19i~CLPA Cl) ISTCkICAL APTT,-IE (4)9 I-ISTCRICI'L 12ICCPAPIY (4),I-ISTcmY CF mEOICINE9 19T1- -TNT. HISTCRY CF VENIPO~E, 20TH CE:-'T.,OVAL.APIA/ I-ISTCPY

FLATZ C-9 Th-ANGKUL Lo, clItck cGLLCLSE-6-0WO PHATE iCEIYCP,-trEVA5E DEFICIENCY Atir JAt",'rlCl INNF6ACP INFANTS IN NCRTIHEF Tt.ATLdN!r.ANN PAECIAT 'ASEL) 203:3q-.45% 1964*RLCCq~ CI-FICAL ANALYSIS, *EP~YTH)O'4LASTCSISq FFTAL, *.XCHANCETPA NsFLSICN, *CLUCC5FPI-C~rIwATE DFH.Y-m DCCENASE DFFICTVr'tCY,IEPATCCRIT* rNFANT, 'kElC P', *JAUNrl~Cho NEC.MATAL, P- '" APIA,PiETmCCLCvr~N, THAILtNC~ (11, umPiLiCAL CC~r

FLATZ (o SRINC.AM So KCPKRtc VsNFCATyVE PjhLAI.CIN-GFACTCRS FC!? TIHE CLUCCSE-6-PHCSPt4ATFCFI-YvOCCLNASE PCLYPCFPIIS' I' TWAILAND.ACTA r-ENET (BASEL) 13:316-77?, 1961*ANFrIA9 H.LWcLYTIC, ANTIll:;LA!?ALS9 ipl rISja5F5, *rtPERAlPAL Yr, C I-L C R A PP -EN I C CL 9 (c~rTICS, I-U'lOA! o *LLCOSFPH '5PpATF~ 'Ek-y-CPCf-ltACE CEFICIEAICY, *Pi4YFF"ILIRO'INFI'lJA, INFANT, NFWL~cqm$*JA1t.r)fICE, NVrNATAL, NWP--ALENES, KNITRCFLPA(JTC~r.,,I-FKYLl yIpAZ V. E, PRL6-NANC., c GUIMV~rNE9 SLLFCNAfiIti5, T'4AIL:INV(1), TrxICCLCG-1C PEFCRT (4). VITAM-IN K

(CCPJPAFAT!vF f'AT-CLCCy CF AECSCSPCr,,TA))IS )I'EC PAFAZIT (rCSKVA) 34:68-,-949 NCV-CFC 65*VA~LAVIh/ PATICLCGY, *MAL.rlit/ VFTERINAPY9 PATI4OLCGY, VFTFPI'!APY

I.CAQO. CA(T-F PELATICNSI-IFS f.'ETIFE' 5p'A11N AP'C HLtVAi, r'AL~rf.?l. I FrrTICr.S)

PFL PAPAZIT (t"CSI(VA) 34:67'-b2, NCV-CFC 65 RS

HLVYr, (09) *V'ALARIA9 *fVAj ARTA/ VEIERIVARY, *MCNKFY 1lISFASES

NEYFR SLRVEILLANCE METHiCCS TIN TH4E CCNTRCL CF CC9.'PUN!CAt-LE rTSFASE@Io WALACIAe EXPERIENCF IN% y 1 . FWILIPPINES*PITLPA-K P'EP FL-NO QLART 43:-Aq6-';o, APC 65*P'ALAPIA CCN~TcCLo PI-ILJPP'TNE ISLANnS (1)

-Ifr5C9 %Ar/ Cis CI-'L CPCFRTAII. LN'LSUO"L ?PANIFFSTAT-.rNF. OF Tf?-TIAN MALARIA,CI-Ir ' "Er J (P'KlejC') e4:3C7..12* ViAN' 65CIA~tCI5, CIcFFRFNT1,AL, TCkLY rl1 EAS'ESs LTVIFR LTSF 'c75, L LNGGISF~ASE5, Y -L AR IA,9 iFL!:rL.VtUC ANJFESTATTtIS9 P5THCLC(-.YgPFIG r'iITY

i.I J- FwiAH'I 11G, SEVGIrA CCIi' -F-;.%/E ACCCO'T CF- TI-r 'ALA'wIA Lp4[ICtITTCN OIL,.T PPOJECT I-N~ALAYfl'iV~FC J ?ALAYA 21:3-25, SEP Af.I-UYAr, (4),s *'ALAPIA/ PR%;1:1K It CC1'T;CLp "ALAYSIA (1) s kCR Lli-EFALT-~ CkCANIZATICN

(PEPCRP' C?' T~-i PRESEN~CE C9 A'CPPELE5 IN SLCVAKIA) ((Z)8ICLC((TA (HRATISL) 18:309-1?, 1963*ANC-.LES9 CZECI-CSLrVAKT- (1) *4LARIA

IPA'TCv vpq SA!<CVIC. CIL( rLLY CF TI-E INSECTICIrE ccrNsITIVI'y CF ?JALAOIIAL MCSC.1ITOES Irl THNASALLY AhG ASTPAr\A-EAZA APE.AS CF TI-f AMZFPATJAr S1bP IN 1961.(RFSULTS CF T E 2nl YEAR CF rFSEPVATICN)) (RUS)?VFC PIRAZT1 (V'CSKVA) 32:271-41 , MAY-JLP 63*AtxCPI-FLE5, AZERP AIJAN (lit *PCTo *CIELCRIV9 *N'ALArTA COr\TPOI.

(CEPL QAL CISrtLSS1CN CF CI~c. '.JC PCLYV1CPP1'CL5 LIGHT EPI;PTTON) (JAP)I.IF( PIIKSI-C 6:467-79, JUL P4ACPrfAL CCRT~x wCPVJCIrS9 -lTThISTA?INICS, ANTjK.ALAfRIbLS*CLAMbTFTCATI',t *CEI.O'ATITils COlALCTPCPINS, 1NICry!1P'If ACyr.PATH.LLCCY, Ic1CTCSENSITiZtfICNq REvIE;N (4), QIRrFLAvTN

KA!Y1.-ZACF ND9 C'EP CE(2 CAS5ES CF- CALCIFICATICN r-r ' CFT TISSLES FCLLOtOIN- TI.JOAPPUTIC'GLI?'INE IIJECTIrNS) (P1,5),vE5Tr'. FENTGEN RACICL 39:677: PR- 4~AOR 64*CALCTI\CSIS9 DRLE TI-EIRAFY' OHpI.y *OALARIA9 *CUININE9RAVCyCC-kAP1-Yv TCXICCLCC-IC -FprRT (4)

KA \A CFI Yo YiASUTAKE T(DI5(jRCEpS CF CCNSCICLSNE~e IN SEPICtS CCr'!LrICAEBLE uicEAs~s) (JAP)CLI ' ALL F-CLN' (CSAKA) 13*:,.59-619 APo; 64*PF~lpi APqCES59 *EKCFpI'AL'TI', !NIAN!Tt *mALAvIAj *!;ERToSTITISOPI-YSIUCCY9 .M'E1rJCNIA9 OPLTI~vCf\IA, LCLIARs *SEPTICFI:A,*TyPH-CIC, *U,'CrN SC ICUSNEF~ *wATEq rL5E-FQI1rEOICHSEN Sv'4rCRCPC~,N %LTLO'c CISFA E

'2

KCZ V-I, AP'CN 71,q (PRACTICAL ImPCPTANCL CF C-SISTANCE TC INSECTICICES IN AFPICA ' OLTtH

CF THE' SP'-AAA FCR LjG~UIC.ATh'tr. CF NALAPV.A CN THIS CC1,1TTFN4T) (PLS)tFC VA;,AZIT ('CSKVA) 33.33--89 IOAYmJLt\ 64AFt T(A (1), aPpiCA9 SCLTI-!I.. ul', INSECTICIrE RESISTANCE,

* *It' LCTIC!LES% II"ALARIA Crl"TrCLo *VCSCLIlr CCNTRCL

* Kqlv,.5I-EEV P TET(TCXIC EFFECT CF SyNTWETIC ANTIP)ALAPTAL PqLPAPATIC4 1. PAJtT

%tID- LATE CLTINECLS PCRPI-Y.-TA) (RLS)VF;Sy;. CERi' VE.'EP 38:60-5, Lr 64*AiT!PA'LAPIALS9 *CER'ATIT*Tc *ErICAmFNTCSA, *ppnF'yi.T',, fSK I WLY'SFASE5, TCXICCLCGIC REP,-oT (4)

KLLTKCV ILA(SE SITIOTy rF P. VIvAx f',."ftT5 TO THE ACTICN "FHENATcSCl-!ZCTPCPIC C;UEfS) (RUS)MEL[ PARAZTT (NCSKVA) 3'.:66i-6o NCv-r.FC 65*CI-LCPCCLANjGF/ PH.ARtPACCDvY "~'TC~q *PLASW~CDGlt/ D)Ptr- FFF CTS,*CLTIACQIKE/ rHARACCYrAP',(S, *r~U!NJNE/ PPAR~tC'~yNAJTCS

KLLSCVF ce!EPVATTCNS CN TH~E FL-FECT OF SPLENECTCtPy UPON THE~ TATwAKFCNIKLY (PA'CACA CyCLCF IS) 1, FE17TFD %ITH PLASMCICILM INUT.J FC~KtC5A NEU ASS 63:214-21% 28 APR 64ELCCL9 ElPER!VENTAL LAe SijlcY (4) *VALARIP*' P-CNKEYS9PLAS'CCILM, 4'SPLFNECTCffY

LAC - Aj~p .J(PALAPIA CLNTPCL IN TH'E V1TI"'I' OFMCCRATIC PFPLuPLIC) (P0Lv~IAr PAPAZYT 11:639-469 lq&K-e'Ar, (4), *4ALARIA CCV'T;;rL* VIFTNAM M1

LIL LH9' LI FCt CHIL TYA STun~Y Ch THIE MEC..ANISP~ r, APIAEM!A IN %iITF PvATS INFFCTFD WIT'-'PLASFCrIL/ P!EQC44EISCI -5P ICA 13:479-87, PdAR o,4*A FNTA* ECNF VAPRClh EXA" ?NATI(rNq EpYT -RCCYTE Cr LNTq

EXPFkII'ENTAL LAP STLCY (4): *IPALARTAt PATS

LLPPCVA AN P~CPCZCVA ZAp S-kL5FI%,IA TV(MALAcPIA IN TIE CI'LVASI-. A~cc "LP1NG THE FIN11. STA,--F OF ITSEPArICATICN) (RUS)NrE ARAZ17 (,ICSKVA) 32:26A,-7C, IVY-JtA 63*V ALAPIA ,CNTPCLe, LSSR 1

23

LYSFiKC pA, rCZCr)C~p GF9 P-L-YKCV FS(FPYLFvTCLC.CAL INDICATIr c eCp FXAMINATICV ')F VLCCL~ FOk E'ALAPJAC( k.T! C TI-F PUrICC CF '!ALA-';. rprp-yLa1(I (ACCrR!IN. TC PESLLT IN'

VFI 451 ( CSKVA 14:5q--e. SEn-UCT 65IIw.(4 ) N'IA'A/9c *kALA9'I8/ RFFtTC' t C( lTPr.Lv

TAI.7i,TPKTSTAN (1)

NK4IErYKC 11, Lr'VITSiTI EP;FFccCFTrN IN (LI,%-CAL IP-1E N~At VErI(ITNF~ AC ITS F(r5FIPL!- crFEFFLTS) (RUS)SCVFT f- 27:72-8, P"' 64ANTIT.ALAI~RALS9 *ARTI-QITIS: ELVTil *Cl-L(RCGUIv~'q *#CrLL~E,lCT~rF;'SES4 *CrRmATITIS, AT-c01C, rpt..C- t-EAPY, *C-LCMF;. uLoC -FPI-;FIIT 1S0I-YFLPSFNSITIVITy, *lrNF F61LUPEO AC.-TF, *NP~reCTIC SY, DRC;'F,TCxy~..I CC-IC H'PCrIT (4)

VA/FLlV N I(A~ rCi\S CF C.';-TAT" MALAPIA TI LAMK) (RLS)

NECI o-APA.ZTT V'CSKtVf) 34:351o -AY-JUN 65AZtPAIJA (1)9 CsASL RFPC T (4), 9 ILMA' (4), *f'ALAk4,.

MARTi.4 1A(CN LTI~rATICN ANCt SteEc. FNT PpFVE-NTCf. CF P1ALAola It- 7T-c LC"UPTALTrCttCLS ScvIET SCCALIS; wrpueLyC) (PUS)N~FL V4 dhZTT (*.C5KVA) 33 :71-4 v JAIFFMi 64*V ALPP I A CCI'7T"CL, L55R (li

lV!V4QI~r\ /'C(CL.c FxPLPIEN~CE %ITI- TI-E A LTCATYCIN CF VALAPIA A'C Co%(EA:NZATICN OFVFA5LPES FGR TI-F pREvFNTIr. Cc TTS IRCL-REfCES It, T14 SHAMSHArTNRECTCN CF TI-E ARVIENJPA! Sl- (RUS)ZI- FKSP ILIN VED 5:96-89 lrA.5APVFN'IP 1), H-.dJAN (4), ,PVALAOIA CCN4T'CL

IM';KLLL E'CM~FLTCICCSISs,ji% 2C1:4909 7 AUC 67CIA8(,C5 15 9 CIFFERENTIAL, mFEVEP/ DIAC-NCSIS9 *0'ALAPIAl LUTAGINCsIS9*RELICIrCrSI/ DIAG3KCStS, TLITARY OFflICJNE, TQCPICAL "EnTCIP~rpL'ATUn STATES M*) VIETtSA (I)

(P'Nr.CIPi'L ASPECTS CF ENyr CLC.CAL CCf-!TI;CL rLip r H AoI.JOVAtLA ,IA (CNTRrL IN T-F L". . rE~VPVATICl"5 CA, TH.E PC;pUL(-TIo-' CF

* ANC~r.FLFS AFTrFR T1wE IlTFRP, PTJCN: rp THE LSE CF Ih~CTTCJ!)F It'LIvDIC- CLAk.TE;7c* 1) (PUS)?VFC FAPAZIT C''CSKVA) 34:7-11, JAN-FF6 65

IAkr IELES* *VALAR'I, CCNT~rL* *PiCS(.UTTC Cc'!&TFCLo LSbP (1)

24

(CAIIAJC ACA'INSJ ?IALARTA TV- f"L"I(4TEU SALT it "JFk 6tif.FA) (DL.TItFCr-tL T C-EVUESK 1C'P:1241--a, 20 JUN o4NCI-L..QCCuTf.E, '*PALApIA Cr. T gCL* 14Ftw CLJr'Eft (1), PFA.4A,CCLCCv,-

*PYCPFT AV I' 9*CL1?'CLIP.-c, *4S;rTL' CILC; jri

(CJ% i-CPPi.nh CtTAINEA 1ARrA) US

*L'SCL~bJC ACI o 91ILLEf. cLCp P;XCV-t?' rLrC~t~)pI.CcGSTS,

*PCPPI-YQIA, OTI-IAI'F, 1.. TU , VITAIJ. E. 1?

rVCLr,AP J(, VCCfk5 AV,OLACIN~ATFP FtvER OFTLP TI-F i s rF

*pyp~IrTl-AIrj%z9 CLjI.NE, TCYICCLC -IC PFPCPT (4)

tNrTF C. T -E , icrxivi ct- IC~IIFLrS CAMPL57PIS, K11j '11; CM TTSC1FAFrEARACE FOLLCINGC ';-; ,E-SfnRAyltr ,-ITV- PFSTLUAL TlSLCT I C I rES

*ANco4ULLco ~C T *I Fixr Te j, fALAPIA CCN"TIDCL* P'AL.-Y5IA (1)

VCCF,*CL E LE5CY'F F.T~vLLV:I(AL A OECT rF THE VLaPIA EF !:! i Lu)T ppCJi~cT

j VFL. ENTCP 2:109-199 %JI.NEfTC[-CLCC-Yo I-LMAP, (4),9 0 AL41/ CC TPCL, OALAY51A (1)

?MCPT;.AC-A V(FkAL4TICpjI ASPEC1' If. TlI E rE T 4ENT :F ThE-jLMTCI(; 4PTP,~TTT5) (JAP)CLI" ILL CL!' (CSAKA) 12:;12q-14 , N~v 63ACRFf.AL CCrcTEC H'CPf"CIES9 fTI LARTALS9 OAO-7JTJC, *.w1~LPIATCIDqCC'cP 1t' CCRTTCCTPCPI%'q F'-FiCjSE T,.-FQA;PY, *CCLC, Pp;MYL? UTA?0NEjP)YCAL TI-FR3PY9 PIYSJCL:r~Ye kFH~eL!TATTCr, c~ST9 Se.LICYLATFS

(C I FTI-CI' Cr- [ETECTYCK r, AcyMPTC"ATIC CAPP~IE'vS rF 0; APTAN

- CAIkPIFP STA&TE, 1--IPA (4), *IAAIi/ lrC~-PC5IS

M vIC ArZF OE# C1-*~ r~r 1. SAWrZVELAOZE rV(LPIFC -tP(mT?.A . tt.ALYSTS IrF SYKT)4ETIC ANTMALARIALPPIPOATIrN) (RUS)

*AtTI 'LAQJAL% C -f.Q'ATCC Ao-y, FLLrQESCEr'cr

W-iCw i Ajo FPAVLC A f ,TFPrN,'iC A!(rrTTCLN CF PLASIYCULW~ r. BLF IN toCSCC- Alyr.15 5UPjJ CT5 JNIFECTFO I'AEST AFR-ICA) (RUS)IVFC 1.. AZUT E*C5KVA) 341:83.q. JA'-FEIP55

PP4%aL-KCf~ tLC'.A TE(C\ Ildf FPCeLU' CF C~r-0'17 .TIrf, LF &i. TVALAPtAL PFFN)I11F PVEASUR~b

PFL di-&A2T1 (-CSKVA) 12:26'.-79 VAY-JO~ 43*FA'ILAPTa CCKVTPCL, 01-AVAL rLICTNF

1FxPL~j,1LfTAL 5T7IDy (F AN -1TIIMALARIAL 'R- i-i4LCtriT11F V(yCLCjltT *Iv.p (r1f~p4j51S, CP 7I-E PPCr-..'0LCTIC 9CTj(:N CF IJAL(/~jlIF AiP'

CI-LCHCCL1t LSEC IN L'"LtL 'C PS) ~Al\TPJ&!. cXPiEKTS ('9) * TTVIILAR!ALS/ TI-FPAPFLTIC USF,*CI-LLQCC,,.TI\E/ TP'ERAFLOIC cro CC-MOAPATIVE STLO(Y (4,)o *PALAPIA/FR~jLNTTcN 6 CC1717CL9 v I C

PAbTIXV!C9j(- !A. fOC5I-KLVIT cI-'fExPL~lwkhT8L 5TiYIES CK A- A' TIALA61[AL Pf EFAF,.TToN I."LCOL.INE(CYCLrCL1P.L), I* (cCI'bkATY F 5TLCTE5 Ct TI-E PF1rArbJTZnTRCpICACT~vITY (1 -ALCG;U1Nj AN~C L tCGU'IN A-,41f;1STEPif% Tf vA~eMIJ POSES)-

(RU 5)VFC PAV.AZTT ("CSKV,4 13:47,-B-t JutL-LG S4*AI\TJ'mALAPjALS* *0~CL'~ ExPtRTPENTAL LAPJ STLDY (4)9,

YLAklfig P -AMACCL,, * F<:LTFY, *CLNCLIkES

R~t TII.VTC9- SAcExPE Iv-PIAL STVAFIE CN A TVAAI'L Pr"CPEPTIES C)" P AOGUINE* IlePCESIclLITY CF Th-F CEVELCP FKT 'I htALC;r.LINE FFSISTUNCE AV~C31\tsALAkIAL PARACIIES) (RLS)WrE AFAZTT ("CSKVA) 3':911 j4:-F~FP 65'*AN71k'LAtFIALC, FP'E~vV~L LAe ST,.ry (4)1, *PLASOCriim~ mALAII~t

CCLCIT~ltdCLTNIf 1,FIPAFVO FC:.' ACLT ' ACF4' LA1 ~~I'

CLPiNF1T ALAPIA CCNTVrl Pt.*"LrNI '%Nt'P? f4CpFIkr5PACL IvEL 3?:P34-'.Ct A,--6

LArLI 1, 9 W-0,~ (41) OPALAi..' / PvEViENTICI\ G Cc',NTI.CL* (4''*

5AAVt j., JEFFERY I~s WAQCI V

FPCCt5SIVE El-r.rCA71rht CF 'IAL'1AL CISF?4-51 I' "F~k '-UjA-0l

VF o ALAYA 70:322* JO Ai.H.tP 1 (4) 9 *ALAvIA/ pVL hT'LV. f, CCAJTi;CLo llrL 1,F,' 11

SAI\!LSI At A~A, YAP LF, CNAF iA MAL4.TA FAk'QT7F, ILAtir. ' (VT(4CKeFTA) eccL1ATT 51;oflvo, FFrm A

PALAYAt, (1/,'N7 FVINC SCl; FL.

*FCCT~A' CISEASES

5.,NrL!-A AAs LEI4NETT COF, YLA PLOSVCL1LM SP9 FFCtt A GL c-cv TfWFE-STJriLII\. (AVULC:T V~AIAYEN.5TS

;e IPi S, F)XPEV IW'ENITAL LAE cTV'Y (4) 9 VALAYSIA (1), 0* LS'L!I1,M

SEAC~IFV PC9 T!PLRKAjP KAO ,LL% ,e CS

(Ct CI-E FCSSVJ-LITY CF 71-Fr EILI'.v\T 4-t Y "AL~rit

FIrLLt~k.IC dLCCC TPANSFLSIC eY T ,F A[CUV1:jTPATCt. CF G, LCC'T'F TC7J9'E i-FCF IEP'T1 (PUS)

PvFC r.AUAZTT V"CSKVA) 32:6qL-7f'0, rCV-DEC 63*ANIMtALARIALS9 OtLCC T6i.!,FL~IrNq *'tALAI1A

SFIRC-1F.V FC,9 TIbURSKAIA VA(TI-F tNt PE#.CFNT FXISTE CF rF 5TPA1NS CF F. %OIVAX hTTP ' LC- N'5I-CP1 INCLL-ATICt: rEPIrDS) (PUS)

Pe~r (PAAZT t%'CSKVA) 32.57.-dl s SCP-CCT 63AFFS ALAjiTA9 ,PLASPhIfr -I VI\06X

P7

5ECEV P-C Ct HA"I NA1t NNO i,-LvVVA To%(T r: PF(CRESS ANC FLTLFF r-,crECT5 CF TI'E CCP*PLFTF FFkAf.'CATICN OFj

V 6 LA~I Thf LSSH PUS

*'IUAT 1 C0 T;CL, LS FP ( I

*51-Lrt Y' Tv,o RtLK, F~C1pLtTYFI\T LF r1-LCLPCCLlNF-P.cIcT3NT PLAS"Crl]1 1VALCTPAP..tl T FECTIrP--S

ANt. 1'TCF P Er (-6:616-27?, AP6*CH.-LPCrL~t!,/ THEPA'PELTC ef U P5r'NF/ T -FFrt.LTIC U5 F H.LPIN(4 ), *v~ALAFIf/ CLL TI-FRki-Yo *VILITMNY !l.rICjkE. *PfFIPI.T-AVIliTI-Cr-iPLL.71C LEcE, CLI!\ACRI. F/ TFEI A'PEUTIC LSr, *rIN'rTl-P.:,PFLTlC L E, 5LLcAr~IA-Yf.T/ 1IPEPAPELTIC t5SF, 5ULFcVAMTrF.S/

TP~~LL Lc UC, VILT~AIV 11

5-tf(. Sri YF CY9 c'E?.c- 5i-

dY ?'Lfrf, Cl- A"Prt\TLV' QEjf%F ATE) (CH)AMT Pi-ARk 51" ICA 12:j 62-6* VT 0~

(r'TCLIFTTIti OF TI-E CCtNC'TtATICN ,.NC ELJIv'l"4.TjrPI OF &J.LCGLI,?EAf\- C-LrrCCL~t 'k l ITF Pf'o'L Art C'ICKENS). (P.LS)VFL: Pt;6ZIT c CSKVA) 34:69,7-61, NrV-,-EC 65

VP7AILSV9 CCMFAPATIVF il.ClV (4) mTCE9 PCULToy

SPENLPR TFi-AFV~LCLJN LrVELS It TH-E r'lElT,,ECASTEALX. ISL/ANrs IW' PULATON TOVA~-T APE,. N' TPlTICN~WFI: ij AL5T 2:1093-7, 3 IEC 66ACL!, Cl-IL~q CH-ILL% WRFc0rLL, i-EAL1I- SLr\/EYS* *"'CCLCOI'V

Wt'LAPIA/ bLCC I Ek~ CLIPLA (1), '\1TOITICIV SL'qVFY59 Pe.F-NW'~Y

(TFF r'I-YSICLCrICAL CISFCST.T' CF BkTA DICHrCWNF, AN ALKALGIC f-FCII-,irA FFL8PjrLCA LCLA) (CHI)

*ALKmLCTL59 *At'ALC-ESICS b~ r NTIPY4t.TICS9 .wA4TIMALAPIALS, PTLF9*PICLCEICAL AS/ty, ELMC 14-E-IrAl A ,ALYSIS9 EXPFf,.To-Ei.TAL LAPSTLrY (4,FCS MC.eTS ETAeCLIS119 PATS, t. P It-

TI*JS.AI'AA ONAq Zt-LXCVA 7A, "t.Fkf.~AP; '06

(A (ASE ff 'OLAC FARNT-fTE CF r.UAtTA*,, vAiAWIA PQAjTkS LAST var,SFVrP.AL V~RS (RLS)P'FL AhKAZJT I'C51VA) 34:01.1* JA-' 6t,

PRlC( ::IL.iA1 FFTAY r V-e TIfFECTJCN AFTF:',A 51-irPY 16TCArTICA )

Ttlt SAIANA, VNU.LLVSKAT.- CJA 5ir1.-TFPtC (Cl.,i=SE CF ThP% TO.ATMfNT 0F 1E~Jl TA14.I-ALrC. If, ASSC(1IATFC ~17- f~ MrfC IL) L)I'FI' rAPAZ!T (''CSKVA) 33'm3i-A* JLL-MlC 64

OATv-LPAc flRU T9-L-ry, *t..trfCL NFS

IPAsLAPIA CCfN.V.CL ItA IHL CF C~cATIC IWPPL*C CF -VIFTI-AF) (PCL)

(CETLRVW!,.jeIC' CF Tf-. (%LIH-p r-g fv'Sr-LjTCES lr' fASFOIN SLCvAKIA) (CZ)

L bTLMA teRA7IL) 19:8'3-, 1964CZECItf5LC',AKIA (I)# *PALA; IA CCNTRC.Lv NtCSCUITCFS

VAK -MCW~l 11,(ANTIvALAFIAL CPLC'S V' T-F Tf~rAlJVNT rF CI-RrIjC !NFLAM"'Tn-,YARTheKCPATI-IF5 ASSCCIATEC l~vTi- P;CQlA5STS) (RL.S5)YFf( i.QVI- ?6.8o-S NCVr 64

VCSTLK~CvA K~q AL.LJEO. h/3CCIAC-NCEIS CF CLARTAI. P'AL; lA'l CRlS)

.- EC FARAZ!T ',,CSKVA) 33:72,.tt ikov-;EC 64

CIAC~5T~. "ALARIA

K400L P, CCATNEY CNo SKAK-Fi. JCPLASVC4LP JE.FFFR'1I 509 h. vpp I vLCeATES LAFR It' W(lAymgi~j FANASIT 52:9-13, FL" 66,GP.pJAL EXPEI'ENTS Wo) I. V1TpC 14)9 *PJALApj~s VALAYS I A (1)IPrj(.ACCf.'P, OYWI~EY rn1SEA~r5s PFHCrOIC 1TYo *PLASyryuf.'

Lf

FcI r~F11F Cc YCLNE T~rFI-r 'CITTS CF FC04J S"!FCIVS Cr PLAvY~lhiASCIT 52:14.-6s FLu 66

'A j#vi.I. ryrf p, i'T5 14) s c it Scl~ T -EWET~f (1 cYT:.nr(vTE

*r-LA~9Jrj V/ rLASc4_!F1fPT1 ' 7 .LCtTrS

TIt \,CTCOS Cr StJ'AI PALA'?~ Ttrh, ITY, IJIrLCr(-Nv, t.fr UAI I

AF4TC.6 (lit OAE~CP -ELF5, 9 Sr To-FA5TEkP (1, LAYc~IpCA~cf

SCLTh V'HQICA (1)

%L YLVt P(FvT rprCESS CF A- 7 It ALAL I L M-(5) 4Ci.

VPI.Alf r(A co.TP LrCTC' .5 FXPL-*1FNC 11 T!,F P.FvFITrr Of To rVSFMT CF

j wb PFL A55 5':393-4CC, s; 6

*Pkf.,'IA GR,; Ic;E;ys L "yA/ P;PivtUTjr, 6 CC' TPflL SHjFC

*ATM/.LOPIALCt 7I rI A it I 4WL4klA, *'"LAP4 CC;PTP'CL