advance health solutions, llc

Advance Health Solutions, LLCWe have the key to solving problems™

1www.advancehealthsolutions.com Toll-free Tel: (866) 330-0596 Main Fax: (858) 876-0132

♦♦ Advantage SolutionsInsight

Advance Health Solutions, LLC is a premier health care consulting firm that offers a broad range of integrated services and solutions to diverse clients across the health care market sector. We specialize in health and financial outcomes measurement, analytics, technical/scientific writing and results dissemination. Our over 200 senior professional consultants and expert board members leverage their in-depth industry and academic knowledge coupled with advanced technical skills gained from decades of experience in the health care arena to support our clients with:

♦ Measuring key indicators demonstrative of impact on health and financial outcomes subsequent to use of a product, technology or service intervention

♦ Analyzing the comparative effectiveness of new and emerging products or technologies relative to competitive benchmarks for targeted therapeutic indications

♦ Increasing bottom line financial gains through strategic product or technology positioning for short-term and long-term commercialization

♦ Publishing the body of evidence related to a given product, technology or service for a variety of stakeholder audiences including consumers, providers, payors, and policymakers through peer-review journal articles, practice or policy briefs, white papers, trade journal articles, and abstracts for presentations at scientific, medical, and public health forums

♦ Writing highly competitive grants and proposals to secure funding for conducting research studies, delivering intervention services and implementing health-based programs

Measurement

Outcomes✓ Clinical✓ Economic✓ Quality of Life

Process✓ Tool/Instrument Design✓ Data Collection/Field Roll-

out

Analytics

✓ Quantitative and Qualitative Data Analysis

✓ Market-centered Gap and Opportunity Analyses

✓ Disease Area Reviews✓ Meta-analysis✓ Clinical Evidence

Compilation and Analysis for Legal Cases

Technical/Scientific Writing and Results Dissemination

✓ Publication Plans✓ Systematic Literature

Reviews✓ Peer-review Journal

Articles✓ Scientific Abstracts✓ White Papers✓ Technical Reports✓ Evidence-based Marketing

and Business Collateral✓ Grants and Proposal

Development

Our Core Service Portfolio

Diverse Therapeutic and Research Competencies

Advance Health Solutions, LLC



✓ Alternative and Complementary Medicine✓ Anesthesiology (e.g., anesthesia and

analgesia)✓ Arthritis (e.g., rheumatoid and osteoarthritis)✓ Behavioral Health✓ Biostatistical Applications✓ Cardiovascular Disease✓ Communication/Health Promotion✓ Dermatology✓ Diabetes✓ Disease Management✓ Disparities in Health Care✓ Emergency Medicine✓ Endocrinology✓ Epidemiology✓ Family Caregiving✓ Geriatrics and Gerontology✓ Health Economics✓ Health/Medical Informatics✓ Health Policy✓ Hematology✓ Hepatitis✓ HIV/AIDS✓ Home Health Care✓ Hospice and Palliative Care✓ Immunology (pediatric and adult)✓ Infectious Diseases (pediatric and adult)✓ Kidney Disease

✓ Infertility (male and female)✓ Managed Care (e.g., Medicaid, Medicare,

private payors/insurers, and Veterans Administration)

✓ Medical Devices (across various sectors)✓ Neurology and Neurovascular Conditions✓ Nutritional Health✓ Oncology (pediatrics and adult)✓ Ophthalmology✓ Orthopaedic Surgery and Sports Medicine✓ Otolaryngology, Head and Neck Surgery✓ Pain Management✓ Pediatrics (across all specialty areas)✓ Pharmacology✓ Pharmacy Benefit Management✓ Primary Care (e.g., preventive care, internal

medicine)✓ Physical Therapy and Rehabilitation✓ Post-Traumatic Stress Disorder✓ Pulmonary Medicine (pediatric and adult)✓ Psychosocial Health✓ Radiology✓ Sexual Medicine✓ Sickle Cell Disease✓ Substance Abuse✓ Thoracic Surgery✓ Urology✓ Violence (e.g., domestic and non-familial)✓ Women’s Health (including OBGYN)

About Our Services and Solutions


Measurement Services and SolutionsBenefits to our clients: Effective data collection requires consistency and validation over time in order to generate the intelligence necessary to inform business development, market access, product or technology commercialization, health service delivery improvement, and operational efficiency enhancement.Deliverables include: Identification and capture of quantitative data such as health outcomes (e.g., improvements in physical, cognitive, and emotional health), economics (e.g., pharmacy costs, hospital costs, and physician costs), and quality of life indicators. Qualitative data can also be collected and evaluated including testimonials, patient satisfaction, focus group opinions, and key informant interviews.

Analytic Services and SolutionsSystematic Literature and Disease Area ReviewsBenefits to our clients: Provides an in-depth, comprehensive assessment of the burden of illness as it relates to market access, commercialization of a product or technology, and opportunities for optimally positioning health care interventions.Deliverables include: Disease background (e.g., comparative epidemiology and natural history), disease burden (e.g., costs of illness and number of lives impacted), treatment options, comparative health outcomes across existing and future therapies, economic outcomes, comprehensive bibliography and recommendations for short-term and long-term action steps (e.g., key insights for marketing a new product or technology for optimal commercialization).

Gap AnalysisBenefits to our clients: Determines the best product or technology positioning strategies and tactics by examining the difference between a productʼs or technologyʼs “current market position” (position A) relative to “the desired market position” (position B).Deliverables include:

♦ Strategic gap analysis – Examines various strategic paths to bridge the existing gap in the marketplace through market segmentation, market penetration, diversification, and product development

♦ Tactical gap analysis – Examines various approaches for closing the gap through critical analysis of the marketing mix such as practice, place, promotion, people, process, and evidence-base

Health Economic and Opportunity AnalysesBenefits to our clients: Provides a description, compilation, and detailed evaluation of the costs and benefits of a new product or technology to the health care system (payors), providers (physicians), society and/or consumers (patients) in comparison to accepted “gold standard” treatments to demonstrate compelling added value propositions.Deliverables include: Therapeutic area landscape that profiles the opportunity (e.g., epidemiology and disease cost burden), return-on-investment (ROI) analyses, health economic piggy-back studies (e.g., cost-




minimization, cost-benefit, cost-effectiveness, cost-utility, or cost-consequence studies), and budget impact modeling (e.g., Markov models, decision trees, and other forms of predictive modeling), competitive advantage delineation (e.g., the most compelling value propositions), and recommendations for short-term and long-term action steps for optimal commercialization.

Health Outcomes Benefits to our clients: Demonstrates proof of efficacy of using a new product, technology or therapeutic service in improving patient-reported outcomes to substantiate product or technology inserts and labeling claims, define health benefits that are beyond traditional end points, generate strategies for improving health care delivery while maximizing return on investment (ROI), and raise awareness among providers, consumers, and payors.Deliverables include: Identification of appropriate study designs, sample size and randomization schematic determination, strategic metrics selection including minimum data set (MDS), data collection parameters and tools, electronic database creation, preliminary and advanced statistical analyses (e.g., modeling), and results generation and interpretation.

Formative and Summative EvaluationsBenefits to our clients: Guides strategic business decision-making, demonstrates return on investment (ROI), allows for comparative impact assessments across similar programs, services or products for health policy determination (e.g., reimbursement by payors), determines feasibility for program replication or expansion to broader market segments, and helps determine more efficient resource allocation.Deliverables include:Formative Evaluation

♦ Needs assessment – Determines the target market; extent of need and services and solutions to meet need

♦ Feasibility assessment – Determines best evaluation approach; assesses how stakeholders view the utility of the evaluation

♦ Structured conceptualization – Defines the program, service or product; identifies the target population(s) and impacts (intended and unintended)

♦ Implementation evaluation – Monitors fidelity of program or product♦ Process evaluation – Investigates the strengths and weaknesses of the process of delivering programs,

products or services as a quality improvement strategy through comparative analyses

Summative Evaluation♦ Outcomes evaluation – Investigates causal relationship between the program, service or product and

outcomes in the target population





♦ Impact evaluation – Assesses the overall or net effects (intended or unintended) of a program, service or product on the target population

♦ Economic evaluation – Comparatively examines the cost-effectiveness or cost-benefits of a program, service or product relative to alternatives or accepted “gold standards”

♦ Empowerment evaluation – Qualitative and quantitative metrics are examined to determine program effectiveness as it relates to empowering self-care activities and awareness

♦ Secondary evaluation – Examines existing data sources gathered for purposes other than evaluation to address outcomes and impacts of a program, service or product offering (includes meta-analysis)

Full-scale Evaluation Services and Solutions♦ Development of short-term and long-term evaluation plans♦ Prospective and retrospective evaluation designs♦ Study group or sample selection (probability and non-probability, purposeful, and convenience/

haphazard sample)♦ Process and outcomes metrics selection♦ Creation of data collection instruments/tools with validity and reliability assessments as well as

response-item scaling and validation♦ Electronic database design and implementation♦ Data preparation and qualitative (e.g., ethnography and phenomenology) and quantitative (e.g., logic

models) analysis♦ Results dissemination and publication♦ Competitive and non-competitive proposal development♦ Training and education workshops in evaluation strategies

Results Dissemination Services and SolutionsPeer-review Article Publications and Other Scientific Forms of WritingBenefits to our clients: Helps clients create well-devised publications that target health care providers, consumers, and/or payors at appropriate venues that maximize credible visibility. All publications generated undergo critical internal and external peer-review before delivery of final product to clients. Our talented professionals collectively serve on more than 100 editorial boards and review committees for health-focused peer-review journals. In addition, many of our senior health advisory board members serve on invited task forces for leading national and international health and policy conference planning committees, affording us the added insights necessary for developing successful publications.




Grant/Proposal DevelopmentBenefits to our clients: Provides comprehensive support for all aspects of grant and proposal development including literature reviews and syntheses for background and significance sections, study and program design, analytics, reporting and dissemination, and budgeting. Our network of professional consultants have a proven track record of successfully securing competitive grants from federal government agencies (e.g., Department of Defense, National Institutes of Health, Centers for Disease Control and Prevention), state agencies, academic institutions, and philanthropic organizations (e.g., foundations).Deliverables include:

♦ Literature review and synthesis – Supports the background and significance sections with a review of the therapeutic area landscape, the burden of disease, and currently available treatment options

♦ Study design and analytics – Identifies the most appropriate study or intervention design and justifies the proposed metrics selection, data collection and management, and analytic strategy

♦ Budget development and justification – Supports completion of budget and justification forms♦ Comprehensive bibliography – Compendium of all relevant references



Deliverables include: ♦ Publication plans♦ Peer-review manuscripts (e.g., original

articles, practice/policy/research briefs, case reports or series, editorials, perspectives, and commentaries)

♦ Books or book chapters♦ White papers♦ Position or policy statements

♦ Evidence-based marketing collateral♦ Scientific abstracts (e.g., oral and poster

presentations)♦ Technical reports♦ Research and evaluation protocols♦ Professional newsletters♦ Trade publication articles



West Coast Office

4370 La Jolla Village DriveSuite 400San Diego, CA 92122Tel: (858) 646-3050Fax: (858) 646-3097

Midwest Office

875 North Michigan AvenueSuite 3100Chicago, IL 60611Tel: (312) 373-3767Fax: (312) 794-7801

East Coast Offices

245 Park Avenue, 39th FloorNew York, NY 10167Tel: (212) 803-8101Fax: (212) 792-4001

2200 Pennsylvania Avenue, NW4th Floor EastWashington, DC 20037Tel: (202) 507-5635Fax: (202) 507-5601

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advance health solutions, llc

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