add the missing piece to the liver’s metabolismstimulant factors hepabial+ = the liver hepabial+...
Post on 25-Aug-2020
0 Views
Preview:
TRANSCRIPT
Hepabial +Add the missing piece to
the liver’s metabolism
32
Add the missing piece tothe liver’s metabolism
Hepabial+ ROLE
The liver is the metabolism central laboratory in animals. Its reserve capabilities are absolutely essential in animals with high production level.
To offset these different critical stages during the rearing process, it is necessary to provide support for the animal’s liver and kidney functions.
A unique combination of ingredients selected to stimulate energy metabolism and to optimize overall performances of animals.
Signs observed :
Reduced appetite Drop in laying rate Reduced immune defences Reduced ADG Stress sensitivity Increased mortality
CONSEQUENCES OF LIVER DYSFUNCTION
L-carnitine(10 g/L)
Transports long chain fatty acids
Allows storage / release of fats in case of high energy needs
Choline(150 g/L)
Allows bile to ensurefat digestion
Helps with fat digestion
Lipotropic factors**
An original targeted formula
Liver toxicity
Mobilisation of reservesmetabolised by the liver
Kidneytoxicity
Improved energy metabolism
Special features of Hepabial+ * Diuretic: substance which leads to increased urine secretion ** Lipotropic: substance which adheres to fat or facilitates its transformation*** Choleretic: substance which facilitates bile secretion, cholagogic: substance wich facilitates bile evacuation
Supplementing the diet with Hepabial+ makes it possible to overcome the energy deficiency linked to all liver dysfunctions.
Better performing animals Improved ADG and FCR Optimized reproductive performances Reduction of fatty liver syndrome
Carbohydrate metabolism(blood sugar regulation)
Iron and vitaminstorage
Fat metabolism (Fatty acid synthesis,fat storage control)
Bile secretion(helps with lipids and
carbohydrates absorption)
Protein metabolism(Protein and urea synthesis)
Cholagogic andcholeretic*** factors
Sorbitol (400 g/L)
Encourages bileproduction and secretion
Stimulates liver activity
Helps with fat digestion
Artichoke Black radish
FumitoryDandelion
Stimulates appetite Encourages bile secretion Stimulates toxins elimination
Diuretic* andstimulant factors
Hepabial+
=
The liver
Hepabial+ Hepabial+
TRIAL N°1 TRIAL N°2
PROTOCOL PROTOCOL
RESULTS RESULTS
CONCLUSION
CONCLUSION
2 buildings with 21300 one-day-old broiler chicks in each one Control group : no supplement Treated group : 1 ml of Hepabial+ / L of drinking water for 2 days in every feed change periods
4 buildings with a total of 99 500 one-day-old broiler chicks 2 control buildings : no supplement 2 treated building : 1 ml of Hepabial+ / L of drinking water for 2 days in every feed change
periods
The calcultation of breeder’s economic results for his two buildings shows a net margin improvement* of 6% with Hepabial+ at each feed change period.
On average, supplementing broilers with Hepabial+ at feed change periods allows to improve breeder’s margin of more than 28 % thus an economic gain of 1.40€ / m2.
* net margin = income - (feed cost + chick cost + Hepabial+ cost + other costs)
* net margin = income - (feed cost + chick cost + Hepabial+ cost)
+ 6 % net margin* for breeder
- 27 % mortality
+ 28 % margin* thus +1.4 € / m2
- 15 % mortality
Effect of Hepabial+ supplement on mortality, average daily gain and body weight (trial august 2008). Effect of Hepabial+ supplement on feed conversion ratio, mortality, average daily gain and body weight.(trial august 2008)
Control group
440
55.1
2.07
Control group
1.98
504
52.6
2.12
Mortality
ADG (g)
Body weight (kg)
FCR
Mortality
ADG (g)
Body weight (kg)
Treated group
320
57.1
2.15
Treated group
1.83
429
52.1
2.11
Evolution
-27%
+3.6%
+3.9%
Evolution
-7.3%
-14.88%
-0.94%
-0.47%
54 Hepabial+
Efficacy on broilers at feed change periods Efficacy on broilers at feed change periods
Hepabial+
Increased body weight gain : + 3,3% Decreased feed conversion ration : - 6,7% Improved liver function
Improved immune response
PROTOCOL
360 broilers divided into 6 groups
Dosage : 1ml of /L of drinking water for the first 3 days of life then 3 days at each feed change period (D1-D3, D15-D17, D29-D31)
Hepabial +
Group 1 Group 2 Group 3 Group 4 Group 5 Group 6
Hepabial+ - + - + - +Aflatoxine B1 - - + + - -Ochratoxine A - - + + + +
RESULTS
1) Zootechnical performances
2) Blood parameters (levels of liver enzymes and bile acids)
3) Immune response (Newcastle vaccine)
Vaccination at the hatchery and on day 9
Compensastes for loss of growth caused by the mycotoxins Reduces feed consumption even with uncontaminated feed Supplementing the diet with Hepabial+ improves the feed conversion ratio
Better liver function
Higher antibodies titres in group treated with Hepabial+ Aids of immune response
2600
2620
2640
2660
2680
2700
2720
2740
2760
No mycotoxinsAflatoxin and
ochratoxin Ochratoxin
Body weight gain (g)
+ 0.64 %+ 3.26 %
+ 2.85 %
3750
3800
3850
3900
3950
4000
4050
4100
4150
No mycotoxinsAflatoxin and
ochratoxin Ochratoxin
Feed consumption (g)
- 4.55 % - 3.87 %
- 4.18 %
1.3
1.35
1.4
1.45
1.5
1.55
1.6
No mycotoxinsAflatoxin and
ochratoxin Ochratoxin
Feed conversion ratio
- 5.23 %- 6.69 % - 6.87 %
Control group Hepabial+ group
0
50
100
150
200
No mycotoxinsAflatoxin and
ochratoxin Ochratoxin
Blood AST* concentration (U / L)
- 5.29 % - 11.85 % - 25.71 %
0
1
2
3
4
5
6
No mycotoxinsAflatoxin and
ochratoxin Ochratoxin
Blood bile acids concentration(µmol/L)
+ 9.16 %- 41.25 %
- 48.5 %
0
0.5
1
1.5
2
2.5
3
3.5
4
No mycotoxinsAflatoxin and
ochratoxin Ochratoxin
Blood ALT** concentration (U / L)
- 6.1 % - 5.9 %
- 31.77 %
Control group Hepabial+ group
0
Antibodies titres ELISA** (S/P)Antibodies titres HI* (log2)
2
4
6
8
0
0.2
0.4
0.6
0.8
1.2
1
No mycotoxinsAflatoxin and
ochratoxin Ochratoxin
No mycotoxinsAflatoxin and
ochratoxin Ochratoxin
+ 29 %
+ 5 %
+ 14 %
+ 16 % + 45 %
+ 18 %
+ 44 %
+ 20 % + 9 % + 26 %
+ 2 %
+ 48 %
Control group D9 Hepabial+ group D9
Control group D42 Hepabial+ group D42
* AST : Aspartate Aminotransferasee** ALT : Alanine Aminotransferasee
Indicators showing hyper-solicitation of the liver
{
* HI : Haemagglutination inhibition test** Elisa : Enzyme linked immunosorbent assay
CONCLUSION
Hepabial+ supplement counteracts the negative effects of mycotoxins
76
Efficacy of Hepabial+ with broilers whose feed is contaminated with mycotoxins
Hepabial+ Hepabial+
Laying curve maintained above strain standard : + 5% egg production during treatment period
Reduction of feed consumption : -6% during the period
Appetite remains unchanged during product distribution
Improvement in liver function
Improved appetite
Improved digestibilityPROTOCOL
Evaluating the benefits of a Hepabial+ supplement in hens during laying 1 test building : 31 950 laying hens treated. 4 treatments (3 to 4 weeks apart) Dose : 1ml / l of drinking water for 5 days. Treatment 1 : W 58 / Treatment 2 : W 61 / Treatment 3 : W 64 / Treatment 4 : W 68
Hepabial +
95
90
85
% la
yin
g
80
75
70W40 W42 W44 W46 W49 W50 W52 W54 W56 W58 W60 W62 W64 W66 W68 W70
120
115
105
100
110
95
90
85
80
Batch treated Standard Feed ingested
ing
este
d(g
)
RESULTS
20
40
60
100
Blo
od
hep
atic
en
zym
eco
nce
ntr
atio
n (I
U /
L)
80
0Before treatment After treatment
-30%
13,27 6,14
81,43
56,6
ASAT
ALAT
-54%
Effectiveness of Hepabial+ at 70-80 days in beef calves during the slowdown in consumption
PROTOCOL
SYSTEMATIC TREATMENTS WITH HEPABIAL+
RESULTS
304 calves treated (2 batches)Distribution of 5ml of per feed per treated calf for between 5 and 70 days.The following were noted : Calves’ appetite Digestibility (consistency of feaces) Blood parameters (ASAT, ALAT)
Hepabial+
Start : added to milk to improve consumption• 5-7 day treatment
At the 70-80 day period : higher concentrate in feed : calves full up• 8-10 day treatment
Isolated treatments : unexpected drop in consumption (heat)• 2-3 day treatment
- 30 % on ASAT level (Aspartate Aminotransferase)
- 54 % on ALAT level (Alanine Aminotransferase)
Indicatorsshowing
liver pain
Effects of Hepabial+ on blood levels of hepatic enzymes
98
Effectiveness of Hepabial+ in laying hens
Hepabial+ Hepabial+
Effect of supplementing sows with Hepabial+ at birth
Effect of supplementing sows with L-carnitine during pregnancy and lactation
+ 6% body weight gain of piglets ( statistically significant difference)
Improved reproductive performancesFaster growth of piglets
PROTOCOL PROTOCOL
86 sows in trial, divided into 2 groups : Control group : no supplement (30 sows) Treated group : either 1 ml of Hepabial+ /L of drinking water during the 5 days after birth (37 sows)
or 1 ml of Hepabial+ /L of drinking water during 5 days at the 3rd week of lactation (19 sows)
The two treated groups are not differentiated because there is no statistically significant difference between them.
127 sows in trial of which 40 gilts. All the animals are divided into 2 groups : Control group : no supplement Treated group : 125 mg of L-carnitine / day / sow during pregnancy
250 mg of L-carnitine / day / sow during lactation
1
34
2
5
8
7
6
0Birth body weight Weaning body weight
7,13
1,77
6,85
1,91
Treated group Control group
RESULTSRESULTS
Evolution of piglets average body weight (trial 2008)
Performances evolution of treated group in comparison with control groupEvolution of treated group performances in
comparison with control group (trial 2008)
Control group
12.8
1.9
6.9
5
Number of piglets / litter
Body weight of piglets at birth
Body weight of piglers at weaning
Body weight gain of piglets during
lactation
Treated group
12.6
1.8
7.1
5.3
P
NS
NS
NS
*
* Represents statistically significants effects : p<0.05 NS : no significatif : p>0.05 +6%
Litter weight at birth
+8%
+7%
Gilts
Sows
Piglets weight at birth
+9%
+6%
Body weight gain during lactation
+12%
+4%
Litter weight at weaning
+14%
+10%
CONCLUSION
CONCLUSION
Supplementing with Hepabial+ after birth allows to support sows appetite, a better use of feed, leading to a faster growth of piglets.
A supplementation with L-carnitine during pregnancy and lactation periods improves reproductive performances of sows and allows a faster growth of piglets.
Differences between the control and the treated groups are more significant with gilts.
Source : Ramanau A, Kluge H, Eder K, J Anim Nutr 2001Source : Ramanau A, Kluge H, Spilke J, Eder K, J Nutr 2004
1110 Hepabial+ Hepabial+
Vers
ion
02/
2016
Biolink Limited,Halifax Way, Pocklington Ind. Est., Pocklington, York YO42 1NR. United Kingdom.Tel: +44 (0) 1759 303444 - Fax: +44 (0) 1759 303158Email: info@biolinklimited.co.uk - Web: www.biolinklimited.co.uk
Hepabial+ The personalized solution
Star
t
Del
ayed
g
row
th
Feed
tr
ansi
tio
n
Hea
t st
roke
Stim
ula
tio
n
of a
pp
etit
e
Stea
tosi
s
Stre
ss (d
ensi
ty,
rele
ase.
..)
layi
ng
pea
k
Layi
ng
su
pp
ort
Broilers X X X X X X X
Turkeys X X X X
Pullets X X
Laying hens X X
Forced-feeding ducks X X X
Muscovy ducks X X X X X X
Lactationpreparation
(before giving birth)
Lactation peak(ingestionsupport)
Feed transition
Heat stroke
Breeders X X X
Fattening rabbits X X
Weaning AcetosisFeed
blockageHeat stroke
Hepatic overload
after treat-ment
Fattening calves X X X X
Cattle X X
WeaningLactationsupport
Feed blockage Heat stroke
Sows X X
Piglets X X
Fattening pigs X X
Instructions for use :Hepabial+ is used diluted in drinking water.Poultry : 1 ml / L of drinking water for 5 to 10 daysCalves during fattening : 1 ml / L of liquid feed for 5 to 10 daysOther species : 1 ml / L of drinking water for 5 to 10 days
top related