alspac clinics larisa duffy – clinic manager l.duffy@bristol.ac.uk

ALSPAC clinics

Larisa Duffy – Clinic Managerl.duffy@bristol.ac.uk

The beginning

About 14, 500 pregnant womenAbout 12,000 new born babies were measured

Children in Focus (CiF)

Clinic Attendance

Young People @17

Observations

• Blood – Glucose, haemoglobin,lipids & cotinine

samples– DNA samples

• Urine and Hair– Chlamydia/gonorrhoea tests on behalf of the

National Chlamydia Screening Programme

• Blood pressure and pulse rate

Anthropometry

• height, weight, body fat, scoliosis • a whole body scan and a hip DXA scan• A pQCT scan of the lower leg

Computerised questionnaire• mental health (depression)• substance use (tobacco, alcohol & drugs)• Gambling • DCSF

Interviews• PLIKS and CSQ• N Back, Probability and Go No-Go

Questionnaires

• on chronic pain, life events and fractures • dental health questionnaire to take home and

send back by post in ALSPAC packaging• girls are given a questionnaire about their

cycle, the date of the first day of their last period and contraception.

Scans

• carotid artery in the neck• liver• heart

Monitors• activity monitor (G-Force)• blood pressure

Clinic ChartYP 1 YP 2 YP 3 YP 4 YP 5 YP 6 YP 7 YP 8

8:20 Blood Blood Blood

8:40 Blood Blood Blood

9:00 Artery Com Q Intview Blood Blood

9:20 DXA BP Com Q Hair

9:40 DXA Intview BP Com Q Hair Com Q Com Q Artery

10:00 Intview Com Q Hair Com Q Artery DXA

10:20 BP Hair Com Q Artery Intview DXA

10:40 BP Hair Com Q Artery DXA Intview

11:00 Com Q Com Q Artery DXA Intview BP

11:20 Hair Artery DXA Intview Com Q BP

11:40 Com Q DXA Intview BP Hair Com Q

12:00 BP Com Q Artery Hair

12:20 Com Q

Mothers’ Observations

– DXA scan for fat & lean mass and bone density– Carotid intima media thickness– Blood pressure– Height, weight, waist, hip and head circumference– Fasting blood samples (funds to complete assays on

fasting glucose, insulin, pro-insulin, lipids and to store serum)

Mothers’ clinic chart

FW1 FW2 FW3 FW4 FW1 FW2 FW3 FW4

08:000 Blood Blood            

08:200 Blood          

08:400 DXA A1 Blood        

09:000 A1 DXA A2        

09:250     DXA A2 Blood Blood    

09:500       DXA Blood  

10:100         DXA A1 Blood

10:300         A1 DXA A2

10:550             DXA A2

11:200               DXA

Fathers’ Clinic

• Fasting Blood sample• Height, weight, waist and hip circumference• Blood pressure• DXA scan• Life style questionnaires