barry bunin open science summit at the berkeley intl house 2010

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CDD aids Collaborations

ResultNew leads reveal known drugs that reverse chloroquine resistance

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Yes We Can!

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CDD Successfully Builds Collaborative Drug Discovery Communities

• DDT, 2009 (14: 261-270): • $1.89M Tuberculosis B&MGF Project• >5 Years CDD SaaS in the Cloud • Thousands of scientists engaged:

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CDD Platform

• Modules:

• CDD Vault – Secure place for private data – private by default

• CDD Collaborate – Selectively share subsets of data

• Datasets:

• CDD Public – expanding public data sets

• published compounds

• data from community members

• vendor libraries

• Unique to CDD – simultaneously query your private data, collaborators’ data, & public data

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CDD Database for Your Private Data

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Collaborate Mode 1 – Big Pharma with single login to multiple CROs/Biotech groups

Collaborator 1 Collaborator 2 Collaborator 4Collaborator 3

Consolidated CDD DB

Project A Project DPro

ject B

Company A

Project C

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Collaborate Mode 2 – Peer-to-Peer: Any Data via Any Query Can Be Securely Shared

CDD DB group 1

CDD DB group 2

CDD DB group 3

CDD DB group 4

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New Types of Offerings for a Rapidly Changing Industry

• CDD Community: tap into global R&D via “crowd-sourcing”• CDD Alliance: better management of your collaborations• CDD Customize: fast, good, and cost-effective = agile

Use CDD Vault™, Collaborate™, Public™ for Global R&D Community

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Acknowledgements

Copyright © 2010 All Rights Reserved Collaborative Drug Discovery

• Sean Ekins, PhD, DSc (Collaborations Director – Philadelphia Office)

• Pfizer, Lilly, Concurrent Pharmaceuticals, GeneGo

• Moses Hohman, PhD (VP Software Development)

• Northwestern Assoc. Director of Bioinformatics, Thoughtworks, Inc., U of Chicago (PhD), Harvard (magna cum laude, Physics)

• Sylvia Ernst, PhD (Senior Director Community Growth – Northwest Office)

• Accelrys-Scitegic, MDL

• Andrea Barry (Senior Director Business Dev – N. Carolina Office)

• Accelrys-Scitegic, MDL

• Kellan Gregory (Head Community Interests Group)

• Anna Spektor (Community Advocate, ex-IDBS)

• Eli Lilly & Co.

• Bill & Melinda Gates Foundation

• Initial TB pilot laboratories

• CDD Researcher Community

• 1000s of CDD collaborators from academia, foundations and industry

• ChemAxon Tools (under the hood)

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• Start with Strong Mission & Values• Neglected disease and commercial disease are both core components

• Collaborative culture – share successes and failures, as much as possible

• Tap leading community expertise with industry focused process

• Do Groundbreaking Work• Revolutionary approaches to solving critical health problems

• Imagine what would be possible in an ideal world, practically implement

• Discover drugs while changing the nature of the game

• What if…you had a magic wand?

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Answers for Our Field

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CDD Collaborative Drug Discovery, Inc.

Burlingame, CAwww.collaborativedrug.com

Barry A. Bunin, PhDCEO & President

info@collaborativedrug.com

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