cure of colitis by cd4 + cd25 + regulatory t cells barrette kathleen – dreesen erwin mottet c,...

Cure of Colitis by CD4+CD25+ Regulatory T Cells

Barrette Kathleen – Dreesen Erwin

Mottet C, Uhlig HH, Powrie F

CD4+

CD45RBlow CD45RBhigh

CD4-

CD25+ CD25-

CD4+

CD45RBlow CD45RBhigh

CD4-

CD25+ CD25-

As therapeutic agents?

Conditions

- Inhibit ongoing T cell responses

- Reverse established pathology

Experimental protocol

Experimental protocol

Experimental protocol

Experimental protocol

Experimental protocol

Experimental protocol

CD4+CD25+ TR cells reverse wasting disease

CD4+CD25+ TR cells reverse wasting disease

CD4+CD25+ TR cells reverse wasting disease

CD4+CD25+ TR cells reverse wasting disease

CD4+CD25+ TR cells reverse wasting disease

CD4+CD25+ TR cells reverse wasting disease

CD4+CD25+ TR cells reverse wasting disease

CD4+CD25+ TR cells reverse colitis

CD4+CD25+ TR cells reverse colitis

CD4+CD25+ TR cells reverse colitis

CD4+CD25+ TR cells reverse colitis

CD4+CD25+ TR cells reverse colitis

CD4+CD25+ TR cells reverse wasting disease & colitis

CD4+CD25+ T cells home to the MLN & colon

* P < 0,05

*

CD4+CD25+ T cells home to the MLN & colon

The progeny of CD4+CD25+ T cellsproliferate in MLN & colon

The progeny of CD4+CD25+ T cellsproliferate in MLN & colon

CD4+CD25+ T cells are in contact withCD11c+ cells and CD4+ T cells in vivo