current and future treatments for azoospermia
Post on 15-Jun-2015
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FNA Sites/Testicle!
Sperm !Detection!
Rate!
Finding Sperm in Nonobstructive Azoospermia Microdissection FNA Mapping
Sperm Present
TESE (n=29)
<2 sites sperm/map
TESA (n=38)
All FNA sites/map
“Directed” TESE
>2 FNA sites/map
What Exactly is Metabolomics? !!
In the testis, somatic cells are metabolically “quiet” compared to rapidly dividing germ cells!
Analogy: A pile of bricks along a desert road- indicates something is being built.!
Phosphocholine (PC)!Glycerophosphocholine (GPC)!
Creatine!
Choline!Total Choline!
Lactate!Alanine!
Normal/Fertile !
Azoospermic Men with Sertoli Cell Only !
The Metabolomic Signature of a Testicle
Aaronson et al. !Hum Reprod. 2010!
Aaronson et al. Hum Reprod. 2010
Sertoli cells!
Fibronectin!
Stromal cells!
Leydig cells!
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