drug delivery in nano metal organic frameworks

INTRODUCTION TO

DRUG DELIVERY SYSTEMS

Tony FrancisDepartment of Chemistry

St. Mary’s college Manarkadu

WHY IS DRUG DELIVERY IMPORTANT?

By using DD the ability to engineer controlled localized delivery of drugs might contribute to the :-

1) Efficiency of the treatment and 2) Reduces the side effects.

ENHANCED PERMEABILITY AND RETENTION (EPR) EFFECT & DD It is the property by which certain sizes of

molecules tend to accumulate in tumor tissue much more than they do in normal tissues.

This is because the tumors can induce blood vessel growth (angiogenesis) by secreting various growth factors which helps in tumor expansion.

Chem. Soc. Rev., 2012, 41, 2623–2640

REQUIREMENTS FOR AN EFFICIENT DRUG DELIVERY

VEHICLETHEY SHOULD BE :- NON-TOXIC BIOCOMPATIBLE HIGH DRUG LOADING CAPACITY CONTROL RELEASE AND AVIOD THE

“BURST EFFECT” CONTROL MATRIX DEGRADATION AND

ENGINEER ITS SURFACE BE DETECTABLE BY VARIOUS IMAGING

TECHNIQUES

IMPORTANT DD SYSTEMS

POLYMERIC NANOPARTICLES QUANTUM DOTS METALLIC NANOPARTICLES POLYSACCHARIDES LIPOSOMES CERAMIC NANOPARTICLES CARBON NANOPARTICLES DENDRIMERS

ALL THESE SYSTEMS CAN BE DIVIDED

ORGANIC POLYMERIC NPS LIPOSOMES POLYSACCHARIDES DENDRIMERS CARBON NPS

INORGANIC QUANTUM DOTS METALLIC NPS CERAMIC NPS

THE ORGANIC ROUTE

IN THIS CASE A WIDE RANGE OF DRUG CAN BE ENCAPSULATED BUT A CONTROLLED RELEASE IS DIFFICULT TO ACHIVE IN THE ABSENCE OF A WELL DEFINED POROSITY.

THE INORGANIC ROUTE

IN THIS CASE RELESE IS PERFORMED BY GRAFTING ORGANIC MOLECULES ON THE PORE WALLS BUT IMPLIES A DECREASE IN THE DRUG LOADING CAPACITY

HYBRID ROUTE

THIS IS A COMBINATION OF HIGH AND REGULAR POROSITY WITH THE PRESENCE OF ORGANIC GROUPS WITHIN THE FRAMEWORKS.

ADVANTAGES HIGH DRUG LOADING CONTROLLED RELEASE

WHY MOFS ??

HIGH DRUG LOADING CAPACITY BIODEGRADABILITY TUNABILITY

FIRST DD MOF DENOTED BY MIL-100 & MIL-101 LARGE PORE SIZE(25-34Å) SURFACE AREA(3100-5900m2\g) DENOTED BY—M3X(H2O)2Ln (M3=Cr ,

X=F,OH) L=1,3,5-benzene tricarboxylic acid(BTC) & n=2 FOR MIL-100 or

L=1,4-benzenedicarboxylic acid (BDC) & n=3 MIL-101

Nanoparticles of the mesoporous iron aminoterephthalateMIL-101 synthesised by the hydrothermal microwave-assisted method

ISSUES REGARDING MOFS

STABILITY TOXICOLOGY

THANK YOU…