early warning system for respiratory compromise...in the case of potential deterioration: ... otc...

Early Warning

System for

Respiratory Compromise

1

Investors / April 2020

B r e a t h e V i s i o n

Respiratory compromise

can lead to death

Respiratory compromise is a

progressive condition, occurring

when a patient is unable to

breathe adequately, and it can

lead to respiratory failure or death.

There’s no adequate

early warning signal for

RC today.

And for Corona Patients –

no Predictive Alert

2

B r e a t h e V i s i o n

SafeSed offers Remote

contactless, continuous

monitoring of patient

breathing

3

The system provides early warning

in the case of potential deterioration:

✓ Reduces the incidence of

respiratory compromise in

multiple clinical settings

✓ Huge near-term opportunities

in remote monitoring of

Corona patients’ condition

B r e a t h e V i s i o n

Our achievements. Only 18 months to launch

4

Operational solution

2 patentsgranted and 3 pending

Clinicaltrials

2 completed; Corona

study to start.

3 IIA plans approved

510(K) pre-

submissioncompleted

B r e a t h e V i s i o n

Entrepreneurs, management & engineering

experience

Ditza Auerbach Founder &

Inventor

Physicist experienced

in leading imaging and

machine learning R&D

at Aspect Imaging and

Applied Materials.

5

Menashe TeremCEO

Led several medical

device companies into

OTC and professional

markets worldwide.

Ofer LeizerovichSoftware

Founder & Co-CEO BDR

Technologies,

25 years of experience

in leading development

of Medical and Cosmetic

Devices.

Ziv GevaEngineering &

Manufacturing

Founder & Co-CEO of BDR

Technologies,

25 years of engineering

management in the medical

and cosmetic fields.

Isaac Levy Financials,

Leading Angel

Over 30 years of

experience in fund

raising and multi-

national contracts

B r e a t h e V i s i o n

RCis a top 5

most rapidly increasing

hospital costs

$37 billion in annual

costs with no

innovation

6

B r e a t h e V i s i o n

A burden on all stakeholders

1 in 8 elective surgery patients and 1 in 14 medical patients suffer from RC

7

46,456

19,885

Respiratory FailureCases

Matched Controls

RC associated hospital costs

14.7%

0.1%

Respiratory FailureCases

Matched Controls

RC associated mortality

RC associated

length of stay

21

6

Respiratory FailureCases

Matched Controls

B r e a t h e V i s i o n

Failure

Arrest

Risk

Compromise

Early detection is key

8 * Lee et al., Anesthesiology 2015

97% of the adverse events could be prevented by continuous monitoring of breathing*

B r e a t h e V i s i o n

SafeSed makes sure you breathe easy

SafeSed reduces the incidence of respiratory compromise by continuously monitoring patients.

Two sensors attached to a patient provide

close monitoring of all vital breathing

information remotely, allowing for immediate

intervention, enabling implementation in

multiple clinical settings.

9

Respiratory compromise is a

B r e a t h e V i s i o n

Continuous, Uninterrupted Breathing Monitoring.

10

A true continuous monitor that is actionable

Wireless/tubeless

communication

Low cost sensor. Setup within seconds

Reusable sensor

Disposable patch

Technology embedded

in multi-channel monitor

B r e a t h e V i s i o n

Strategy: Embed SafeSed in Vital Sign Monitors

Creating the

most

comprehensive

patient monitor

B r e a t h e V i s i o n

Standard breathing indicators. All the time.

12

Alerts for

➢ High and low respiratory rates

➢ Shallow breathing

➢ Paradoxical breathing/

Obstructed Airway

➢ Breathing depth trends

Measures

what counts➤ Accurate respiratory rate -

number of breaths per

minute

➤ Breathing volume trend -

amount of air moved with

each breath

➤ Number of Apnea/Hypopnea

events

B r e a t h e V i s i o n

Technology based on machine learning

Sensors

Simple application of 2 wearable inertial

sensors are placed on the patient’s abdomen

and chest

Continuous monitoring

Breathing parameters based on machine

learning: respiratory rate, breathing depths, apnea and obstructive

breathing

Alerts

Nurse is alerted in the event the patient

deteriorates.

Use of big data analysis improves the quality

and accuracy of alerts over time

13

B r e a t h e V i s i o n

The solution: Continuous monitoringUninterrupted monitoring of vital signs could reduce and prevent respiratory compromise

14

Nurse –Manual

➤ Burden on staff leaves

patients unmonitored for

96% of the time

➤ Inaccurate spot-check

entries may not represent

the patient’s true

condition

Capnography – continuous

➤ Measures CO2 in exhaled breath

➤ “Noisy” on spontaneously

breathing patients (open

system)

➤ High costs (system/consumable)

➤ Uncomfortable tubes

Pulse Oximetry –continuous

➤ Widely used

➤ Inexpensive

➤ Alerts are too late for

timely interventions

B r e a t h e V i s i o n

The Corona Effect: Governments and Healthcare providers switched all resources to Early prediction of breathing

deterioration in Coronavirus Patients

15 * Lee et al., Anesthesiology 2015

Coronavirus: An infection disease that affects the lungsContinuous remote monitoring is needed to

detect early signs of patient deterioration who

may require ventilator support.

B r e a t h e V i s i o n

Corona pilot to start at three leading medical centers in

Israel

SafeSed will remotely monitor Corona

patients reducing the risk of exposure to

medical teams and offering early warning

to potential patient deterioration.

The pilot opens huge opportunities for

all hospitals in need of remote

monitoring of breathing

worldwide

16

B r e a t h e V i s i o n

SafeSed is implementable in multiple markets

3 yearsICU/General

Floor

5 yearsHome use:

sleep apnea, COPD, infants

17

Quick

LaunchCorona Patients

2 yearsDuring deep& moderate

sedation procedures

Post-operation recovery room

1 year

הכל זז שנה קדימה–עודכן

B r e a t h e V i s i o n

Unique solutions. Unparalleled opportunity.

18

1

2

3

4

$37bn - Overall burden of RC. Near-term opportunities in Corona

Capnography – The only solution today. Noisy and expensive

SafeSed - Shown to accurately monitor breathing continuously

Clear roadmap to market – Regulatory and business model

Let’s work together to dramatically reduce respiratory compromise

Website: www.breathevision.comMenashe Terem (CEO): menashet@breathevision.comDitza Auerbach (CTO): ditzaa@breathevision.com

19