etb funding success case: starlab - eurotransbio funding success case: starlab aureli soria-frisch...

Starlab Neuroscience

ETB Funding Success Case: Starlab Aureli Soria-Frisch (PhD)

Senior Researcher and Neuroscience Research Program Manager

| STARLAB BARCELONA | LIVING SCIENCE STARLAB NEUROSCIENCE

Starlab – a brief introduction

• A private R&D company based in Barcelona

•We transform Science into Technologies for our Clients

•We develop new products and services with profound and positive social impact

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Starlab – a brief introduction!

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products

•  snow  detec+on•  jellyfish  predic+on•  smart  irriga+on

•  electrophysiology•  electrical  brain  s+mula+on

R+D

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Neuroscience Research – What we offer

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Less  of  this  ...

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Neuroscience Research – What we offer

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Less  of  this  ...More  of  this!

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Neuroscience Research – What we offer

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Less  of  this  ...More  of  this!

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Neuroscience Research – What we offer

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Physiological  Data  Analysis• Protocol  defini+on• Data  collec+on• Data  cleaning  and  ar+fact  removal• Feature  extrac+on  and  valida+on• Effect  classifica+on• Study  valida+on• Data  Analysis  Support  for  Experimental  Work  and  Clinical  Trials

Physiological  Sensor  Systems• Requirements  analysis• Electronic  design• Industrial  design• Fast  prototyping• Test  and  valida+on

Algorithms• Signal  Processing• Computa+onal  Intelligence• Machine  Learning• Data-­‐mining• Modeling  and  simula+on• Data  fusion  and  integra+on

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NeuroscienceNeuroscience - Know-how

Hardware• Fast  prototyping• Sensor  technologies• Embedded  systems• Wireless  communica+ons• Industrial  design

EEGtCS

SUENO

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Funded Research

•  Building  prototypes•  Ideas  harves@ng•  Exploring  new  territories

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NeuroscienceFunded Research

user  state

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BCI

physiologicalbiometrics

Application Areas

brain  sCmulaCon

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CombinationBCI withAssistive Technologies

• Motor imagery• SSVEP• EOG, EMG based

Brain Computer Interfaces

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Biometry

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Brain Electrical Stimulation

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Changes  in  the  Comma  Recovery  Scale  aEer  tDCS

Brain Electrical Stimulation

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EEG biomarkers

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EEG biomarkers

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We  use  EEG  features  to  predict  Parkinson’s  10years  in  advance

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User State

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User State

• Emotional state• Stress• Sleep\Alertness• Mental Workload

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SUENO project - goals

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• Sleep analysis through electrophysiological signals‣ Automate algorithms for sleep

analysis‣ Further development of

electrophysiological sensor device

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SUENO project - work plan

WP1SoA  and  

requirements

WP2Algorithms  development

WP3Device  

development

WP4Experimental  valida+on

WP5Market  analysis

WP6Project  

management

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WP3 Device development

• Original electrophysiological device - Enobio• Frontal electrodes• Band cap for electrode positioning• System was not suitable for sleep studies

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• First development - Enobio 2G• New electrode design in order to allow hair areas positioning• New electrode cap for full scalp monitoring

WP3 Device development

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WP4 Validation

• Recording campaigns‣ Sleep Dept. Sabadell Hospital – C.S. Parc Taulí‣ Siesta Group

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• Validation proposed improvements‣ Improve communication stability‣ Place somewhere else electronic box‣ Improve electrode holder to avoid contact loss during night‣ Nice to have dry electrodes to reduce preparation time

WP3 Device development

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• Final validation ‣ System is validated for detection of sleep macrostructure -

performance equal to standard systems‣ For sleep microstructures detection further improvements are

needed• Final device features - Enobio 3G

‣ Standard Bluetooth communication‣ Larger capability - 20 channels at 500 Hz‣ Improved and more flexible electrode cap‣ Dry electrodes

WP4 Validation

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Enobio 3G

• Wearable• Wireless• Easy to Use

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Neuroelectrics in a nutshell…

Date of foundation: May 2011.

Headquarters: Barcelona, Spain.

CEO: Ana Maiques.

Staff: 4.

Aim: Investigate, develop and market products in the neuroscience area.

Mission:

“To become the trusted leader in Brain Health treatment by providing measurement tools and

making neuromodulation affordable and available for every patient in need”.

General facts

The company has two products:• Enobio: a wireless electroencefalograpy

system, monitoring brain activity in an easy way and already in the market

• Starstim: a novel neurostimulator using tDCS-transcraneal direct current stimulation to treat, amongst others:

• Chronic Pain• Post-Stroke Rehabilitation

Company focus

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Enobio new family of products.

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TARGET MARKETS: Research (CE since Feb 2012) and Medical (CE Medical since April 2012)

20832 on the pipeline

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Signals you can trustFaithful reproduction of the raw EEG signal.Get the reliability of a wired system without the wiresCapture all the data you need

Quality EEG made easyStart recording in less than one minuteEasily visualize and manage your dataRecord where and when you want

Advanced development toolsWork with raw dataBuild your own applicationsSafeguard and organize your research

Features

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NIC visualization and analysis software:• User-friendly EEG visualization• Intuitive time-frequency analysis• Customizable user interface

Software

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EEG biomarkers

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Parkinsonʼs

Alzheimerʼs

ADHD

Schizophrenia

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EEG biomarkers

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Parkinsonʼs

Alzheimerʼs

ADHD

Schizophrenia

Diagnosis

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EEG biomarkers

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Parkinsonʼs

Alzheimerʼs

ADHD

Schizophrenia

Diagnosis

Prognosis

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Physiological Data Consulting Service

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data

largest  informa+onat  reduced  costs

automate  knowledgegenera+on

summaryreport

hypothesislaunching

Data  analysis  partnerfor  pharma  industry

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Cognitive Enhancement

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Study  at  Oxford  University:  tDCS  for  math  skill  boos+ng

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Cognitive Enhancement

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Demen@a

Study  at  Oxford  University:  tDCS  for  math  skill  boos+ng

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Cognitive Enhancement

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Demen@amTBI

Study  at  Oxford  University:  tDCS  for  math  skill  boos+ng

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Cognitive Enhancement

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Demen@amTBIHealthy  subjects?

Study  at  Oxford  University:  tDCS  for  math  skill  boos+ng

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Cognitive Enhancement

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Demen@amTBIHealthy  subjects?Study  aid?

Study  at  Oxford  University:  tDCS  for  math  skill  boos+ng

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Sports Performance

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Neuromarketing

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Mul+-­‐modal  emo+on  recogni+on:  We  gather  emo+onal  response  of  subjects  by  using  electrophysiological  sensors  and  facial  expression  recogni+on

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tCS Applications enter mainstream

• Chronic pain• Depression• Post-stroke rehabilitation• Dementia• Addiction• …

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Pilot  using  tDCS  for  stroke  rehabilita+on  by  our  partners  at  Burke  Rehabilita+on  Centre

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tCS Applications enter mainstream

• Chronic pain• Depression• Post-stroke rehabilitation• Dementia• Addiction• …

• Improve therapies– Non-invasive– Safe– No known side effects– Precise targets

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Pilot  using  tDCS  for  stroke  rehabilita+on  by  our  partners  at  Burke  Rehabilita+on  Centre

Thanks for your attention!aureli.soria-frisch@starlab.es

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