flutamide

Prepare by

The pharmacist Ayia Nazum Kamal

•Capsules:Capsules: 125 mg ,250mg

Flutamide is nonsteroidal antiandrogen )anti-Flutamide is nonsteroidal antiandrogen )anti-) testosterone) testosterone inhibits androgen uptake or inhibits nuclear inhibits androgen uptake or inhibits nuclear binding of androgen in target tissues or binding of androgen in target tissues or.both.both

The t1/2 is about 6 h )active.)metabolite

drug is excreted primarily in theurine with 4.2% excreted in feces

Elimination

Flutamide is rapidly and extensivelymetabolized to at least 6 metabolites . The active metabolite ishydroxyflutamide.

Metabolism

parent drug:94% to 96%Active metabolite:92% to 94%

proteinbinding

Oral: rapid and complete Absorption

-1 Metastatic prostate cancer, combinationtherapy with a luteinizing hormone- releasing hormone )LHRH( analog )eg,.)goserelin, leuprolide-2Treatment of hirsutism in women

-3 Juvenile Nasopharyngeal Angiofibroma flutamide was reported to reduce stage I and.II tumors to 44%

Prostate carcinoma:* 250mg 3 times daily )for a total daily dose of 750)mg

Female hirsutism )unlabeled*use(:250mg daily

-1-1 hypersensivity to flutamide or any.. component of the formulation

_2_2..severe hepatic function impairment

-3-3pregnancy..

GIGI Low potential for nausea and vomiting; diarrhea; hepatocellular necrosis;cholestatic jaundice; elevated LFTsEndocrineEndocrineHot flashes, gynecomastia

GenitourinaryGenitourinary Impotence; reduced sperm countCNSCNSDecreased libido

* cardiac disease)oedema reported(. * hepatic impairment, also liver function tests, monthly for first 4 months, periodically thereafter and at the first sign or symptom ofliver disorder )e.g . pruritus, dark urine, persistent anorexia, jaundice, abdominalpain, unexplained influenza-like symptoms)

Drug InteractionsDrug Interactions Prothrombin time may increase when flutamide therapy is initiated in patients.stabilized on chronic warfarin therapyLaboratory Test InteractionsLaboratory Test Interactions Elevated AST, ALT, bilirubin, BUN, andserum creatinine

The urine was noted to change to an*The urine was noted to change to an*amber or yellowamber or yellow--green appearancegreen appearance Photosensitization may occurPhotosensitization may occur* *

Flutamide and LHRH*Flutamide and LHRH*-- agonists should be agonists should beadministered concomitantlyadministered concomitantly