gominer: (zeeberg et al., genome biology, march 2003) for tour of gominer: advance using forward...

GoMiner: (Zeeberg et al., Genome Biology, March 2003)

For Tour of GoMiner:

Advance using forward arrow

GoMiner: (Zeeberg et al., Genome Biology, March 2003)

GoMiner is a tool for biological interpretation of 'omic' data –

including data from gene expression microarrays. Omic

experiments often generate lists of dozens or hundreds of genes that differ in expression between

samples, raising the question, “What the h-ll does it all mean

biologically?”

To answer that question, GoMiner leverages the Gene Ontology (GO) to classify the genes into biologically coherent categories

and assess those categories statistically.

For biological interpretation of a microarray experiment, the user enters the list of genes on the

array and has the option of flagging them as up-regulated, down-regulated, or neither with

respect to some index standard.

This animation presents a tour of the highlights of GoMiner’s

functionality and user interface.

GoMiner: (Zeeberg et al., Genome Biology, March 2003)

An Unchanged Gene

An Overexpressed Gene

An Underexpressed Gene

Total Genes in Category

Fisher’s Exact p-Value for All Changed Genes in

CategoryRelative Enrichment ofUnderexpressed Genes In

Category

Relative Enrichment of AllChanged Genes in

Category

Relative Enrichment ofOverexpressed Genes In

Category

GoMiner: (Zeeberg et al., Genome Biology, March 2003)

GoMiner: (Zeeberg et al., Genome Biology, March 2003)

NCBI-StructuresEntrez Genome @ LocusLink

PubMedGeneCards

MedMiner

BioCarta @ CGAP

Click on a gene to linkOut to Major Molecular

Biology Databases

Results can also be exported for further

analysis with other tools

GoMiner has an additional visualization based on a Directed Acyclic Graph (DAG) view of your

experiment results and GO

Categories with a depletion of changed

genes

Mouse over a category to see the genes that have

been assigned there

The relationships between the GO categories

Categories with an enrichment of changed

genes

Visit http://dicover.nci.nih.gov/gominer to download and start using GoMiner