heritability of hemodynamic response fun ction of human ...al. biol. psycho emodynamic ahon1, greig...

Post on 02-Oct-2020

0 Views

Category:

Documents

0 Downloads

Preview:

Click to see full reader

TRANSCRIPT

1Cent40

IntroThe hflow ccouplidizygosignifiinvestMethSubjeand 20Cognipresenwere pMR imimageFor eaActivacomm(AG)]HRF

param

time toalso exHRF h

DiscuThe figenetishow ConcThis isto peaRefer(1) Blo

HZuyao Y Sh

tre for Advanced I72, 3Laboratory of

oduction: emodynamic reschanges coupleding mechanismsotic (DZ, fraternicant contributioigated the herita

hods: ects fMRI data w0 DZ twins (10 fitive tasks Parnted for 200 ms performed for twmaging The 3D

es were acquiredach participant, 1ated regions T

mon activation vo (Fig. 1 a, b) thamodeling The

meters ( h(t) = A(

o peak (T), and xamined betweeheritability Dif

ussion: nding of a small

ic influence on nsignificant differ

clusion: s the first study d

ak were found. rences: okland GAM et

Heritability of han1, Katie L McM

Imaging, The Univf Neuro Imaging, D

sponse function d to neural actis is poorly undenal) twin pairs ison to a trait, g

ability of the HR

were acquired infemales, 10 malerticipants performwith 800 ms ga

wo 0- and 2-backD T1-weighted ad using an MPRA127 EPI images The fMRI data oxels for the woat were significane time course o

( tα1−1β1α1e−β1t

Γ(α1)− 1

6full width at ha

en the two scannifferences in H, T

ler difference in neurovascular corences between

demonstrating h

al. Biol. Psycho

hemodynamicMahon1, Greig I de Zversity of QueenslaDepartment of Neu

Queensland I

(HRF) describevity. Neurovascerstood. The tws compared, is agreater concorda

RF in the brain us

n 40 twin subjectes). med the 0- and aps. The participk conditions (8 band EPI images AGE pulse sequ(TR = 2.1s, TE =were analyzed u

orking memory tntly activated wef signal changetα2 −1β2

α2e−β2t

Γ(α2 )) w

alf maximum (Wing sessions.

T, and W within M

HRF time to peoupling factors thMZ and DZ pair

heritability of HR

l. 2008 79: 70-7

c response funZubicaray2, Paul M

and, Brisbane, QLDurology, UCLA ScInsitute of Medica

es blood oxygencular coupling iin paradigm, in

an important wayance is expectesing the twin me

ts, mean age 23.

2-back versionpant performed elocks/condition)were acquired o

uence (TR = 250= 30 ms, flip angusing SPM8 (Ttask. Four regioere selected for Hs was averaged

was convolved w

W) were estimate

MZ twin pairs w

ak in MZ twin phat control the timrs perhaps reflec

RF parameters us

79.

nction of humaM Thompson3, NicD 4072, Australia,

chool of Medicine, l Research, Brisba

nation level depes crucial for no

n which the degy of identifying ed between monethodology.

87 ± 2.27 S.D. y

s of the N-backeach task (0, or ). The same fMRon a 4T Medspe00 ms, TE = 3.8gle = 90, 3.6 × 3

The Wellcome Tns [left and righHRF modeling.

d across activate

with the boxcar f

ed from the fitted

were compared wResults: Similar ac(Fig. 1 a, bare summaobserved i(p < 0.01)differencesstructures differences

pairs than DZ twming of blood en

cting a greater co

sing fMRI data f

an brain durincholas G Martin4, , 2School of Psych Los Angeles, CA, ane, QLD 4029, Au

endent (BOLD) ormal brain fungree of concorda

when genetic fanozygotic twin

years old. Subjec

k working mem2-back) for 16 t

RI session was rec whole body sc3 ms, T1 = 1500

3.6 × 3.0 mm) weTrust Centre for ht middle fronta

ed voxels in eac

function and fitt

d HRF (Fig. 1c)

with those within

ctivated regions b). The HRF diffarized in Table in MZ compared), and in right As in H betweenalthough none

s in W between

win pairs suggestntry into the actontribution of tas

from a working m

ng working mMargaret J Wrigh

hology, The Univer United States, 4Gustralia

signal changes ction but the coance between m

factors are imporpairs than betw

cts included 20 M

ory task as prevtrials as one bloepeated approximcanner (Bruker, 0 ms, pulse angere acquired con

r Neuroimaging,al gyrus (MFG)

ch structure. A

ted with the fM

). Repeatability

n DZ pairs.

were observed ifferences of HRF 1. Significantly

d to DZ pairs in AG (p < 0.03). n MZ twin paire of the differeMZ twin pairs w

ts that this trait isivated area. Widsk-related factor

memory task. G

memory task t4, and David C Rersity of Queenslan

Genetic Epidemiolo

in fMRI data aontribution of g

monozygotic (Mrtant. Where inhween dizygotic

MZ twins (10 fe

viously describeock. In total 16 amated 3 months Germany). The

gle = 15, 0.89 × ntinuously during, London, UK) and left and rig

double gamma

MRI time course.

of HRF paramet

in the two experF shapes within My smaller differLeft MFG (p < There were con

rs than in DZ twence reached swere similar to th

s heritable, perhdth and height ofrs.

Genetic influence

eutens1 d, Brisbane, QLD

ogy Laboratory,

and reflects bloogenetic factors tZ, identical) an

heritance makes twin pairs. W

emales, 10 males

ed1. Stimuli weralternating blocklater. 3D T1-weighte0.89 × 089 mmg the tasks. to determine th

ght angular gyrus

a function with

. The height (H

ter estimates wa

rimental sessionMZ and DZ pairrences in T wer0.04), right MFGnsistently smallewin pairs for a

significance. Thhose in DZ pairs

haps reflecting thf the HRF did no

es on HRF time

d to nd

a We

s)

re ks

ed ).

he s,

5

),

as

ns rs re G er ll

he s.

he ot

2900Proc. Intl. Soc. Mag. Reson. Med. 20 (2012)

top related