heritability of hemodynamic response fun ction of human ...al. biol. psycho emodynamic ahon1, greig...
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IntroThe hflow ccouplidizygosignifiinvestMethSubjeand 20Cognipresenwere pMR imimageFor eaActivacomm(AG)]HRF
param
time toalso exHRF h
DiscuThe figenetishow ConcThis isto peaRefer(1) Blo
HZuyao Y Sh
tre for Advanced I72, 3Laboratory of
oduction: emodynamic reschanges coupleding mechanismsotic (DZ, fraternicant contributioigated the herita
hods: ects fMRI data w0 DZ twins (10 fitive tasks Parnted for 200 ms performed for twmaging The 3D
es were acquiredach participant, 1ated regions T
mon activation vo (Fig. 1 a, b) thamodeling The
meters ( h(t) = A(
o peak (T), and xamined betweeheritability Dif
ussion: nding of a small
ic influence on nsignificant differ
clusion: s the first study d
ak were found. rences: okland GAM et
Heritability of han1, Katie L McM
Imaging, The Univf Neuro Imaging, D
sponse function d to neural actis is poorly undenal) twin pairs ison to a trait, g
ability of the HR
were acquired infemales, 10 malerticipants performwith 800 ms ga
wo 0- and 2-backD T1-weighted ad using an MPRA127 EPI images The fMRI data oxels for the woat were significane time course o
( tα1−1β1α1e−β1t
Γ(α1)− 1
6full width at ha
en the two scannifferences in H, T
ler difference in neurovascular corences between
demonstrating h
al. Biol. Psycho
hemodynamicMahon1, Greig I de Zversity of QueenslaDepartment of Neu
Queensland I
(HRF) describevity. Neurovascerstood. The tws compared, is agreater concorda
RF in the brain us
n 40 twin subjectes). med the 0- and aps. The participk conditions (8 band EPI images AGE pulse sequ(TR = 2.1s, TE =were analyzed u
orking memory tntly activated wef signal changetα2 −1β2
α2e−β2t
Γ(α2 )) w
alf maximum (Wing sessions.
T, and W within M
HRF time to peoupling factors thMZ and DZ pair
heritability of HR
l. 2008 79: 70-7
c response funZubicaray2, Paul M
and, Brisbane, QLDurology, UCLA ScInsitute of Medica
es blood oxygencular coupling iin paradigm, in
an important wayance is expectesing the twin me
ts, mean age 23.
2-back versionpant performed elocks/condition)were acquired o
uence (TR = 250= 30 ms, flip angusing SPM8 (Ttask. Four regioere selected for Hs was averaged
was convolved w
W) were estimate
MZ twin pairs w
ak in MZ twin phat control the timrs perhaps reflec
RF parameters us
79.
nction of humaM Thompson3, NicD 4072, Australia,
chool of Medicine, l Research, Brisba
nation level depes crucial for no
n which the degy of identifying ed between monethodology.
87 ± 2.27 S.D. y
s of the N-backeach task (0, or ). The same fMRon a 4T Medspe00 ms, TE = 3.8gle = 90, 3.6 × 3
The Wellcome Tns [left and righHRF modeling.
d across activate
with the boxcar f
ed from the fitted
were compared wResults: Similar ac(Fig. 1 a, bare summaobserved i(p < 0.01)differencesstructures differences
pairs than DZ twming of blood en
cting a greater co
sing fMRI data f
an brain durincholas G Martin4, , 2School of Psych Los Angeles, CA, ane, QLD 4029, Au
endent (BOLD) ormal brain fungree of concorda
when genetic fanozygotic twin
years old. Subjec
k working mem2-back) for 16 t
RI session was rec whole body sc3 ms, T1 = 1500
3.6 × 3.0 mm) weTrust Centre for ht middle fronta
ed voxels in eac
function and fitt
d HRF (Fig. 1c)
with those within
ctivated regions b). The HRF diffarized in Table in MZ compared), and in right As in H betweenalthough none
s in W between
win pairs suggestntry into the actontribution of tas
from a working m
ng working mMargaret J Wrigh
hology, The Univer United States, 4Gustralia
signal changes ction but the coance between m
factors are imporpairs than betw
cts included 20 M
ory task as prevtrials as one bloepeated approximcanner (Bruker, 0 ms, pulse angere acquired con
r Neuroimaging,al gyrus (MFG)
ch structure. A
ted with the fM
). Repeatability
n DZ pairs.
were observed ifferences of HRF 1. Significantly
d to DZ pairs in AG (p < 0.03). n MZ twin paire of the differeMZ twin pairs w
ts that this trait isivated area. Widsk-related factor
memory task. G
memory task t4, and David C Rersity of Queenslan
Genetic Epidemiolo
in fMRI data aontribution of g
monozygotic (Mrtant. Where inhween dizygotic
MZ twins (10 fe
viously describeock. In total 16 amated 3 months Germany). The
gle = 15, 0.89 × ntinuously during, London, UK) and left and rig
double gamma
MRI time course.
of HRF paramet
in the two experF shapes within My smaller differLeft MFG (p < There were con
rs than in DZ twence reached swere similar to th
s heritable, perhdth and height ofrs.
Genetic influence
eutens1 d, Brisbane, QLD
ogy Laboratory,
and reflects bloogenetic factors tZ, identical) an
heritance makes twin pairs. W
emales, 10 males
ed1. Stimuli weralternating blocklater. 3D T1-weighte0.89 × 089 mmg the tasks. to determine th
ght angular gyrus
a function with
. The height (H
ter estimates wa
rimental sessionMZ and DZ pairrences in T wer0.04), right MFGnsistently smallewin pairs for a
significance. Thhose in DZ pairs
haps reflecting thf the HRF did no
es on HRF time
d to nd
a We
s)
re ks
ed ).
he s,
5
),
as
ns rs re G er ll
he s.
he ot
2900Proc. Intl. Soc. Mag. Reson. Med. 20 (2012)